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Journal articles on the topic 'Neuropeptides'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Veenstra, Jan A. "Similarities between decapod and insect neuropeptidomes." PeerJ 4 (May 26, 2016): e2043. http://dx.doi.org/10.7717/peerj.2043.

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Background.Neuropeptides are important regulators of physiological processes and behavior. Although they tend to be generally well conserved, recent results using trancriptome sequencing on decapod crustaceans give the impression of significant differences between species, raising the question whether such differences are real or artefacts.Methods.The BLAST+ program was used to find short reads coding neuropeptides and neurohormons in publicly available short read archives. Such reads were then used to find similar reads in the same archives, and the DNA assembly program Trinity was employed t

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Veenstra, Jan A. "Coleoptera genome and transcriptome sequences reveal numerous differences in neuropeptide signaling between species." PeerJ 7 (June 17, 2019): e7144. http://dx.doi.org/10.7717/peerj.7144.

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Background Insect neuropeptides are interesting for the potential their receptors hold as plausible targets for a novel generation of pesticides. Neuropeptide genes have been identified in a number of different species belonging to a variety of insects. Results suggest significant neuropeptide variation between different orders, but much less is known of neuropeptidome variability within an insect order. I therefore compared the neuropeptidomes of a number of Coleoptera. Methodology Publicly available genome sequences, transcriptomes and the original sequence data in the form of short sequence

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Pidsudko, Z., J. Kaleczyc, J. Zmudzki, et al. "Changes in the tissue concentrations of several neuropeptides in porcine intestines and intestine-innervating ganglia in the course of porcine proliferative enteropathy." Veterinární Medicína 63, No. 5 (2018): 210–15. http://dx.doi.org/10.17221/62/2017-vetmed.

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Inflammatory processes are associated with changes in the interplay of different pro- and anti-inflammatory factors, including neuropeptides, in tissue. This study was performed to investigate the influence of proliferative enteropathy on the concentration of several neuropeptides known to be involved in the regulation of the inflammatory process in porcine intestine and intestine-innervating ganglia. The concentration of galanin, vasoactive intestinal polypeptide, somatostatin, neuropeptide Y, substance P and calcitonin gene-related peptide were assayed with ELISA in the coeliac-superior mese

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Ryznar, Rebecca, Nathan Andrews, Kyle Emery, et al. "Specific Salivary Neuropeptides Shift Synchronously during Acute Stress in Fire Recruits." Brain Sciences 14, no. 5 (2024): 492. http://dx.doi.org/10.3390/brainsci14050492.

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Once thought of as an immune-privileged site, we now know that the nervous system communicates in a bidirectional manner with the immune system via the neuroimmune axis. Neuropeptides constitute a component of this axis, playing critical roles in the brain and periphery. The function of salivary neuropeptides in the acute stress response is not well understood. The purpose of this study is to investigate salivary neuropeptide levels during acute stress. Salivary samples were collected from fire recruits engaged in a stress training exercise previously shown to induce acute stress, at three sep

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Kaur, Rimanpreet, Naina Arora, Meera G. Nair, and Amit Prasad. "The interplay of helminthic neuropeptides and proteases in parasite survival and host immunomodulation." Biochemical Society Transactions 50, no. 1 (2022): 107–18. http://dx.doi.org/10.1042/bst20210405.

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Neuropeptides comprise a diverse and broad group of neurotransmitters in vertebrates and invertebrates, with critical roles in neuronal signal transduction. While their role in controlling learning and memory in the brains of mammals is known, their extra-synaptic function in infection and inflammation with effects on distinct tissues and immune cells is increasingly recognized. Helminth infections especially of the central nervous system (CNS), such as neurocysticercosis, induce neuropeptide production by both host and helminth, but their role in host–parasite interplay or host inflammatory r

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6

Josefsson, Malin, Magnus Becker, Fritz Stroman, Daniel G. Brenner, and Göran Petersson. "Effect of Recombinant Neutral Endopeptidase (EC 3.4.24.11) on Neuropeptide-Mediated Nasal Fluid Secretion and Plasma Exudation in the Rat." American Journal of Rhinology 12, no. 2 (1998): 135–42. http://dx.doi.org/10.2500/105065898781390244.

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The nasal mucosa harbors sensory nerves containing neuropeptides such as substance P (SP), which are released by capsaicin. The neuropeptides are degraded by peptidases, e.g., neutral endopeptidase (NEP) that is present in the nasal mucosa. We studied the effect of enzymatically active recombinant NEP (rNEP) on neuropeptide-evoked secretion of nasal fluid and plasma exudation in rats. rNEP administered intranasally (i.n.) reduced the capsaicin-evoked nasal fluid secretion but failed to reduce the secretion evoked by SP (exogenous) under the experimental conditions used. rNEP reduced the increa

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7

Sun, Changsheng, Jiatong Han, Yixin Bai, Zhaowei Zhong, Yingtao Song, and Yu Sun. "Neuropeptides as the Shared Genetic Crosstalks Linking Periodontitis and Major Depression Disorder." Disease Markers 2021 (October 21, 2021): 1–13. http://dx.doi.org/10.1155/2021/3683189.

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Background. The aim of this study was at investigating the association between major depressive disorder (MDD) and periodontitis based on crosstalk genes and neuropeptides. Methods. Datasets for periodontitis (GSE10334, GSE16134, and GSE23586) and MDD (GSE38206 and GSE39653) were downloaded from GEO. Following batch correction, a differential expression analysis was applied (MDD: ∣ log 2 FC ∣ > 0 and periodontitis ∣ log 2 FC ∣ ≥ 0.5 , p < 0.05 ). The neuropeptide data were downloaded from NeuroPep and NeuroPedia. Intersected genes were potential crosstalk genes. The correlation between n

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8

Shen, Yi-Chen, Xiao Sun, Lei Li, Hu-Yunlong Zhang, Zhi-Li Huang, and Yi-Qun Wang. "Roles of Neuropeptides in Sleep–Wake Regulation." International Journal of Molecular Sciences 23, no. 9 (2022): 4599. http://dx.doi.org/10.3390/ijms23094599.

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Sleep and wakefulness are basic behavioral states that require coordination between several brain regions, and they involve multiple neurochemical systems, including neuropeptides. Neuropeptides are a group of peptides produced by neurons and neuroendocrine cells of the central nervous system. Like traditional neurotransmitters, neuropeptides can bind to specific surface receptors and subsequently regulate neuronal activities. For example, orexin is a crucial component for the maintenance of wakefulness and the suppression of rapid eye movement (REM) sleep. In addition to orexin, melanin-conce

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9

Wang, Zhengbing, Wenwu Zhou, Muhammad Hameed, Jiali Liu, and Xinnian Zeng. "Characterization and Expression Profiling of Neuropeptides and G-Protein-Coupled Receptors (GPCRs) for Neuropeptides in the Asian Citrus Psyllid, Diaphorina citri (Hemiptera: Psyllidae)." International Journal of Molecular Sciences 19, no. 12 (2018): 3912. http://dx.doi.org/10.3390/ijms19123912.

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Neuropeptides are endogenous active substances that widely exist in multicellular biological nerve tissue and participate in the function of the nervous system, and most of them act on neuropeptide receptors. In insects, neuropeptides and their receptors play important roles in controlling a multitude of physiological processes. In this project, we sequenced the transcriptome from twelve tissues of the Asian citrus psyllid, Diaphorina citri Kuwayama. A total of 40 candidate neuropeptide genes and 42 neuropeptide receptor genes were identified. Among the neuropeptide receptor genes, 35 of them

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10

Liu, Yining, and Min Zhao. "Decode the Stable Cell Communications Based on Neuropeptide-Receptors Network in 36746 Tumor Cells." Biomedicines 10, no. 1 (2021): 14. http://dx.doi.org/10.3390/biomedicines10010014.

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Background: As chemical signals of hormones, neuropeptides are essential to regulate cell growth by interacting with their receptors to achieve cell communications in cancer tissues. Previously, neuropeptide transcriptome analysis was limited to tissue-based bulk expression levels. The molecular mechanisms of neuropeptides and their receptors at the single-cell level remain unclear. We conducted a systematic single-cell transcriptome data integration analysis to clarify the similarities and variations of neuropeptide-mediated cell communication between various malignancies. Methods: Based on t

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Zhang, Long, Lichao Sun, Guanghao Song, et al. "Genome-Wide Identification and Expression of Neuropeptides and Their Expression Patterns After RNAi of CHH Genes in Pacific White Shrimp Litopenaeus vannamei." Biology 13, no. 12 (2024): 1038. https://doi.org/10.3390/biology13121038.

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Neuropeptides are pivotal in regulating a broad spectrum of developmental, physiological, and behavioral processes throughout the life cycle of crustaceans. In this comprehensive study, we utilized a multiomics approach to characterize neuropeptide precursors and to assess the expression profiles of neuropeptide-encoding genes across various tissues and developmental stages in the Pacific white shrimp, Litopenaeus vannamei. Additionally, we explored the differential expression of neuropeptide genes in the eyestalk before and after the RNA interference-mediated suppression of crustacean hypergl

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Lestanova, Z., Z. Bacova, and Jan Bakos. "Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview." Endocrine Regulations 50, no. 2 (2016): 72–82. http://dx.doi.org/10.1515/enr-2016-0011.

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AbstractThe present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the local responses elicited by neuropeptides, there exist certain functional similarities in the effects of neuropeptides, mediated by their receptors. In the present review, data of the relevant studies, focused on G protein-coupled receptors activated by neuropeptides, are summarized. Particul

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Grimmelikhuijzen, Cornelis J. P., Michael Williamson, and Georg N. Hansen. "Neuropeptides in cnidarians." Canadian Journal of Zoology 80, no. 10 (2002): 1690–702. http://dx.doi.org/10.1139/z02-137.

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Cnidarians are the lowest animal group having a nervous system. In the primitive nervous systems of cnidarians, peptides play important roles as neurotransmitters or neurohormones. So far, we have isolated and sequenced about 35 neuropeptides from different cnidarian classes (Hydrozoa, Scyphozoa, Anthozoa). All these neuropeptides have a C-terminal amide group, which protects against C-terminal degradation, but which also is important for receptor recognition. Also the N-termini of the cnidarian neuropeptides often contain different kinds of protecting groups (such as <Glu residues, L-3-phe

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14

Tu, Shisheng, Rui Xu, Mengen Wang, Xi Xie, Chenchang Bao, and Dongfa Zhu. "Identification and characterization of expression profiles of neuropeptides and their GPCRs in the swimming crab, Portunus trituberculatus." PeerJ 9 (September 15, 2021): e12179. http://dx.doi.org/10.7717/peerj.12179.

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Neuropeptides and their G protein-coupled receptors (GPCRs) regulate multiple physiological processes. Currently, little is known about the identity of native neuropeptides and their receptors in Portunus trituberculatus. This study employed RNA-sequencing and reverse transcription-polymerase chain reaction (RT-PCR) techniques to identify neuropeptides and their receptors that might be involved in regulation of reproductive processes of P. trituberculatus. In the central nervous system transcriptome data, 47 neuropeptide transcripts were identified. In further analyses, the tissue expression p

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15

Choudhary, Nilesh C. "A SYSTEMIC REVIEW ON NOVEL TECHNIQUES USED IN THE DETERMINATION OF NEUROPEPTIDE THROUGH THE ANALYTICAL TECHNIQUES." Journal of Medical pharmaceutical and allied sciences 10, no. 3 (2021): 2794–800. http://dx.doi.org/10.22270/jmpas.v10i3.1062.

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Neuropeptides are a group of signaling molecules which are located in central nervous system. They control essential physiological function in animals like cardiovascular activity, energy, reproduction, growth, homeostasis, behavior, and stress response. Neuropeptides are the endogenous peptides they act as a neurotransmitter, neuromodulator and hormones. The detection process of neuropeptides is challenging due to their cleavage by peptidases and undergoes posttranslational modification. The in vivo isolation of neuropeptides occurs at very small concentrations as a significance of the effort

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Semmens, Dean C., Isabel Beets, Matthew L. Rowe, Liisa M. Blowes, Paola Oliveri, and Maurice R. Elphick. "Discovery of sea urchin NGFFFamide receptor unites a bilaterian neuropeptide family." Open Biology 5, no. 4 (2015): 150030. http://dx.doi.org/10.1098/rsob.150030.

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Neuropeptides are ancient regulators of physiology and behaviour, but reconstruction of neuropeptide evolution is often difficult owing to lack of sequence conservation. Here, we report that the receptor for the neuropeptide NGFFFamide in the sea urchin Strongylocentrotus purpuratus (phylum Echinodermata) is an orthologue of vertebrate neuropeptide-S (NPS) receptors and crustacean cardioactive peptide (CCAP) receptors. Importantly, this has facilitated reconstruction of the evolution of two bilaterian neuropeptide signalling systems. Genes encoding the precursor of a vasopressin/oxytocin-type

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Hsu, I.-Uen, Jeremy W. Linsley, Xiaoli Zhang, et al. "Stac protein regulates release of neuropeptides." Proceedings of the National Academy of Sciences 117, no. 47 (2020): 29914–24. http://dx.doi.org/10.1073/pnas.2009224117.

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Neuropeptides are important for regulating numerous neural functions and behaviors. Release of neuropeptides requires long-lasting, high levels of cytosolic Ca2+. However, the molecular regulation of neuropeptide release remains to be clarified. Recently, Stac3 was identified as a key regulator of L-type Ca2+channels (CaChs) and excitation–contraction coupling in vertebrate skeletal muscles. There is a small family ofstacgenes in vertebrates with other members expressed by subsets of neurons in the central nervous system. The function of neural Stac proteins, however, is poorly understood.Dros

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Avgan, Nesli, Heidi G. Sutherland, Rod A. Lea, Larisa M. Haupt, David H. K. Shum, and Lyn R. Griffiths. "Association Study of a Comprehensive Panel of Neuropeptide-Related Polymorphisms Suggest Potential Roles in Verbal Learning and Memory." Genes 15, no. 1 (2023): 30. http://dx.doi.org/10.3390/genes15010030.

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Neuropeptides are mostly expressed in regions of the brain responsible for learning and memory and are centrally involved in cognitive pathways. The majority of neuropeptide research has been performed in animal models; with acknowledged differences between species, more research into the role of neuropeptides in humans is necessary to understand their contribution to higher cognitive function. In this study, we investigated the influence of genetic polymorphisms in neuropeptide genes on verbal learning and memory. Variants in genes encoding neuropeptides and neuropeptide receptors were tested

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Shiraishi, Akira, Toshimi Okuda, Natsuko Miyasaka, et al. "Repertoires of G protein-coupled receptors for Ciona-specific neuropeptides." Proceedings of the National Academy of Sciences 116, no. 16 (2019): 7847–56. http://dx.doi.org/10.1073/pnas.1816640116.

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Neuropeptides play pivotal roles in various biological events in the nervous, neuroendocrine, and endocrine systems, and are correlated with both physiological functions and unique behavioral traits of animals. Elucidation of functional interaction between neuropeptides and receptors is a crucial step for the verification of their biological roles and evolutionary processes. However, most receptors for novel peptides remain to be identified. Here, we show the identification of multiple G protein-coupled receptors (GPCRs) for species-specific neuropeptides of the vertebrate sister group, Ciona

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Mochizuki, Takako, Mika Sakamoto, Yasuhiro Tanizawa, et al. "Best Practices for Comprehensive Annotation of Neuropeptides of Gryllus bimaculatus." Insects 14, no. 2 (2023): 121. http://dx.doi.org/10.3390/insects14020121.

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Genome annotation is critically important data that can support research. Draft genome annotations cover representative genes; however, they often do not include genes that are expressed only in limited tissues and stages, or genes with low expression levels. Neuropeptides are responsible for regulation of various physiological and biological processes. A recent study disclosed the genome draft of the two-spotted cricket Gryllus bimaculatus, which was utilized to understand the intriguing physiology and biology of crickets. Thus far, only two of the nine reported neuropeptides in G. bimaculatu

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Serafini, Gianluca, Maurizio Pompili, Daniel Lindqvist, Yogesh Dwivedi, and Paolo Girardi. "The Role of Neuropeptides in Suicidal Behavior: A Systematic Review." BioMed Research International 2013 (2013): 1–22. http://dx.doi.org/10.1155/2013/687575.

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There is a growing evidence that neuropeptides may be involved in the pathophysiology of suicidal behavior. A critical review of the literature was conducted to investigate the association between neuropeptides and suicidal behavior. Only articles from peer-reviewed journals were selected for the inclusion in the present review. Twenty-six articles were assessed for eligibility but only 22 studies were included. Most studies have documented an association between suicidality and some neuropeptides such as corticotropin-releasing factor (CRF), VGF, cholecystokinin, substance P, and neuropeptide

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Li, Zi-Hao, Bin Li, Xiao-Yang Zhang, and Jing-Ning Zhu. "Neuropeptides and Their Roles in the Cerebellum." International Journal of Molecular Sciences 25, no. 4 (2024): 2332. http://dx.doi.org/10.3390/ijms25042332.

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Although more than 30 different types of neuropeptides have been identified in various cell types and circuits of the cerebellum, their unique functions in the cerebellum remain poorly understood. Given the nature of their diffuse distribution, peptidergic systems are generally assumed to exert a modulatory effect on the cerebellum via adaptively tuning neuronal excitability, synaptic transmission, and synaptic plasticity within cerebellar circuits. Moreover, cerebellar neuropeptides have also been revealed to be involved in the neurogenetic and developmental regulation of the developing cereb

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Ramirez, Manuel, Isabel Prieto, Francisco Vives, Marc de Gasparo, and Francisco Alba. "Neuropeptides, Neuropeptidases and Brain Asymmetry." Current Protein & Peptide Science 5, no. 6 (2004): 497–506. http://dx.doi.org/10.2174/1389203043379350.

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Chen, Kaiqi, Xiaojun Wu, Xiaoke Li, et al. "Antimicrobial Neuropeptides and Their Receptors: Immunoregulator and Therapeutic Targets for Immune Disorders." Molecules 30, no. 3 (2025): 568. https://doi.org/10.3390/molecules30030568.

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The interaction between the neuroendocrine system and the immune system plays a key role in the onset and progression of various diseases. Neuropeptides, recognized as common biochemical mediators of communication between these systems, are receiving increasing attention because of their potential therapeutic applications in immune-related disorders. Additionally, many neuropeptides share significant similarities with antimicrobial peptides (AMPs), and evidence shows that these antimicrobial neuropeptides are directly involved in innate immunity. This review examines 10 antimicrobial neuropept

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Kong, Xue, Zhen-Xiang Li, Yu-Qing Gao, et al. "Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp, Aphidius gifuensi." Insects 12, no. 8 (2021): 745. http://dx.doi.org/10.3390/insects12080745.

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In insects, neuropeptides and their receptors not only play a critical role in insect physiology and behavior but also are the potential targets for novel pesticide discoveries. Aphidius gifuensis is one of the most important and widespread aphid parasitoids, and has been successfully used to control aphid. In the present work, we systematically identified neuropeptides and their receptors from the genome and head transcriptome of A. gifuensis. A total of 35 neuropeptide precursors and 49 corresponding receptors were identified. The phylogenetic analyses demonstrated that 35 of these receptors

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Chalmers, John, Vimal Kapoor, Eric Mills, et al. "Do pressor neurons in the ventrolateral medulla release amines and neuropeptides?" Canadian Journal of Physiology and Pharmacology 65, no. 8 (1987): 1598–604. http://dx.doi.org/10.1139/y87-251.

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Activation of neurons arising in the rostral ventrolateral medulla evokes a pressor response in the rat and the rabbit. This region of the medulla gives rise to bulbospinal neurons containing many different neurotransmitters, including amines such as adrenaline, noradrenaline and serotonin, and neuropeptides such as substance P and neuropeptide Y. Colocalization of amines and neuropeptides has been described in some neurons descending from the rostral ventrolateral medulla. In this paper we discuss the evidence that bulbospinal serotonin-containing neurons (B3) and adrenaline-containing neuron

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Bodea, Alina, and Amorin Remus Popa. "Orectic And Anorectic Peptides And Their Implication In Obesity And The Metabolic Syndrome." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 22, no. 2 (2015): 187–91. http://dx.doi.org/10.1515/rjdnmd-2015-0023.

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AbstractBackground and aims: Cardiovascular diseases, diabetes mellitus, the metabolic syndrome and obesity are now globally widespread clinical conditions, addressing different ages, lately extending to young and children. The causes are multiple, involving an interaction between individual genetic risk factors and environmental factors. Many studies showed the importance of the hypothalamic neuropeptides and other neuropeptides in the regulation of the balance between food intake and energy consumption. We reviewed 25 recent research studies describing the physiological and physiopathologica

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Puri, Sudan, Brendan M. Kenyon, and Pedram Hamrah. "Immunomodulatory Role of Neuropeptides in the Cornea." Biomedicines 10, no. 8 (2022): 1985. http://dx.doi.org/10.3390/biomedicines10081985.

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The transparency of the cornea along with its dense sensory innervation and resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune systems. The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege, in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells. As research in this area expands, further insights are made into the role of neuropeptides and their immunomodulatory functions in the

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de Wied, D. "Neuropeptides as psychotropic drugs." Acta Neuropsychiatrica 4, no. 1 (1992): 1–7. http://dx.doi.org/10.1017/s0924270800034931.

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SummaryNeuropeptides are endogenous substances present in nerve cells and involved in nervous system functions. Neuropeptides are synthetized in large precursor proteins and several are formed in the same precursor. Neuropeptides affect learning and memory processes, social, sexual and maternal behavior, pain and addiction, body temperature, food and water intake e.a. In addition, neuropeptides possess trophic influences on the nervous system, neuroleptic-like andpsychostimulant-like activities. Disturbances in classical neurotransmitter activity as found in Parkinson's disease, psychoses, and

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Solway, J., and A. R. Leff. "Sensory neuropeptides and airway function." Journal of Applied Physiology 71, no. 6 (1991): 2077–87. http://dx.doi.org/10.1152/jappl.1991.71.6.2077.

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Sensory nerves synthesize tachykinins and calcitonin-gene related peptide and package these neuropeptides together in synaptic vesicles. Stimulation of these C-fibers by a range of chemical and physical factors results in afferent neuronal conduction that elicits central parasympathetic reflexes and in antidromic conduction that results in local release of neuropeptides through the axon reflex. In the airways, sensory neuropeptides act on bronchial smooth muscle, the mucosal vasculature, and submucosal glands to promote airflow obstruction, hyperemia, microvascular hyperpermeability, and mucus

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Petrescu, Anca D., Su Yeon An, Juliet Venter, Matthew McMillin, and Sharon DeMorrow. "The Role of Hypothalamic Neuropeptides in Regulation of Liver Functions in Health and Disease." Endocrines 4, no. 2 (2023): 457–87. http://dx.doi.org/10.3390/endocrines4020034.

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The communication between brain and peripheral tissues is mediated by neuropeptides that coordinate the functions of each organ with the activities of the entire body in specific environmental conditions. Hypothalamic neuropeptides act as neurotransmitters and hormones to regulate the physiology of food intake, digestion, and metabolism, having a direct or indirect impact on the liver. Investigations on liver pathologies found that dysfunctions of neuropeptides and their receptors are associated with liver disorders such as non-alcoholic fatty liver disease, steatohepatitis, cholestasis, cirrh

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Muschter, Dominique, Anna-Sophie Beiderbeck, Tanja Späth, Christian Kirschneck, Agnes Schröder, and Susanne Grässel. "Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages." International Journal of Molecular Sciences 20, no. 3 (2019): 503. http://dx.doi.org/10.3390/ijms20030503.

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This study aimed to analyze if the sensory neuropeptide SP (SP) and the neurokinin receptor 1 (NK1R) are involved in macrophage mechano-transduction, similar to chondrocytes, and if alpha-calcitonin gene-related peptide (αCGRP) and the CGRP receptor (CRLR/Ramp1) show comparable activity. Murine RAW264.7 macrophages were subjected to a cyclic stretch for 1–3 days and 4 h/day. Loading and neuropeptide effects were analyzed for gene and protein expression of neuropeptides and their receptors, adhesion, apoptosis, proliferation and ROS activity. Murine bone marrow-derived macrophages (BMM) were is

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Martinez, C., M. Delgado, R. P. Gomariz, and D. Ganea. "Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide-38 inhibit IL-10 production in murine T lymphocytes." Journal of Immunology 156, no. 11 (1996): 4128–36. http://dx.doi.org/10.4049/jimmunol.156.11.4128.

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Abstract Vasoactive intestinal peptide (VIP), a neuropeptide present in the peptidergic innervation of lymphoid organs and expressed in thymocytes and peripheral lymphocytes has been previously reported to modulate cytokine expression in T lymphocytes. In this study, we investigated the effects of VIP and of the structurally related neuropeptide PACAP-38 on the expression of IL-10 in murine lymphocyte cultures. Both neuropeptides inhibit IL-10 production by spleen cells or thymocytes activated via the TCR-associated CD3 complex in a similar dose-response manner. The inhibition is specific, pre

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Mo, Chenmi, and Lei Zhang. "Unraveling the Roles of Neuropeptides in the Chemosensation of the Root-Knot Nematode Meloidogyne javanica." International Journal of Molecular Sciences 25, no. 12 (2024): 6300. http://dx.doi.org/10.3390/ijms25126300.

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The identification of novel drug targets in plant-parasitic nematodes (PPNs) is imperative due to the loss of traditional nematicides and a lack of replacements. Chemosensation, which is pivotal for PPNs in locating host roots, has become a focus in nematode behavioral research. However, its underlying molecular basis is still indistinct in such a diverse group of PPNs. To characterize genes participating in chemosensation in the Javanese root-knot nematode Meloidogyne javanica, RNA-sequencing of the second-stage juveniles (J2s) treated with tomato root exudate (TRE) for 1 h and 6 h was perfor

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Petrella, Carla, Maria Grazia Di Certo, Christian Barbato, et al. "Neuropeptides in Alzheimer’s Disease: An Update." Current Alzheimer Research 16, no. 6 (2019): 544–58. http://dx.doi.org/10.2174/1567205016666190503152555.

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Neuropeptides are small proteins broadly expressed throughout the central nervous system, which act as neurotransmitters, neuromodulators and neuroregulators. Growing evidence has demonstrated the involvement of many neuropeptides in both neurophysiological functions and neuropathological conditions, among which is Alzheimer’s disease (AD). The role exerted by neuropeptides in AD is endorsed by the evidence that they are mainly neuroprotective and widely distributed in brain areas responsible for learning and memory processes. Confirming this point, it has been demonstrated that numerous neuro

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Pearce, Eiluned, Rafael Wlodarski, Anna Machin та Robin I. M. Dunbar. "Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality". Proceedings of the National Academy of Sciences 114, № 20 (2017): 5300–5305. http://dx.doi.org/10.1073/pnas.1700712114.

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There is growing evidence that the number and quality of social relationships have substantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fitness. Although it is widely recognized that these outcomes are mediated by a number of neuropeptides, the roles these play remain debated. We suggest that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish between different social domains, has obscured the complexity involved. We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relati

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Gao, Zhengyin, Weng I. Lei, and Leo Tsz On Lee. "The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells." Molecules 27, no. 1 (2022): 311. http://dx.doi.org/10.3390/molecules27010311.

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Neuropeptides are autocrine and paracrine signalling factors and mainly bind to G protein-coupled receptors (GPCRs) to trigger intracellular secondary messenger release including adenosine 3′, 5′-cyclic monophosphate (cAMP), thus modulating cancer progress in different kind of tumours. As one of the downstream effectors of cAMP, exchange proteins directly activated by cAMP (EPACs) play dual roles in cancer proliferation and metastasis. More evidence about the relationship between neuropeptides and EPAC pathways have been proposed for their potential role in cancer development; hence, this revi

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Bakos, Jan, Martina Zatkova, Zuzana Bacova, and Daniela Ostatnikova. "The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis." Neural Plasticity 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/3276383.

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The hypothalamus is a source of neural progenitor cells which give rise to different populations of specialized and differentiated cells during brain development. Newly formed neurons in the hypothalamus can synthesize and release various neuropeptides. Although term neuropeptide recently undergoes redefinition, small-size hypothalamic neuropeptides remain major signaling molecules mediating short- and long-term effects on brain development. They represent important factors in neurite growth and formation of neural circuits. There is evidence suggesting that the newly generated hypothalamic ne

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Bülbül, Mehmet, and R. Alberto Travagli. "Novel transmitters in brain stem vagal neurocircuitry: new players on the pitch." American Journal of Physiology-Gastrointestinal and Liver Physiology 315, no. 1 (2018): G20—G26. http://dx.doi.org/10.1152/ajpgi.00059.2018.

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The last few decades have seen a major increase in the number of neurotransmitters and neuropeptides recognized as playing a role in brain stem neurocircuits, including those involved in homeostatic functions such as stress responsiveness, gastrointestinal motility, feeding, and/or arousal/wakefulness. This minireview will focus on the known physiological role of three of these novel neuropeptides, i.e., apelin, nesfatin-1, and neuropeptide-S, with a special emphasis on their hypothetical roles in vagal signaling related to gastrointestinal motor functions.

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Zandawala, Meet, Ismail Moghul, Luis Alfonso Yañez Guerra, et al. "Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms." Open Biology 7, no. 9 (2017): 170129. http://dx.doi.org/10.1098/rsob.170129.

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Neuropeptides are a diverse class of intercellular signalling molecules that mediate neuronal regulation of many physiological and behavioural processes. Recent advances in genome/transcriptome sequencing are enabling identification of neuropeptide precursor proteins in species from a growing variety of animal taxa, providing new insights into the evolution of neuropeptide signalling. Here, detailed analysis of transcriptome sequence data from three brittle star species, Ophionotus victoriae , Amphiura filiformis and Ophiopsila aranea , has enabled the first comprehensive identification of neu

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Ombuya, Alfayo, Jianyang Guo, and Wanxue Liu. "Insect Mating Behaviors: A Review of the Regulatory Role of Neuropeptides." Insects 16, no. 5 (2025): 506. https://doi.org/10.3390/insects16050506.

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Insect mating behaviors are complex, diverse, and primarily regulated by neuropeptides and their receptors. Neuropeptides are peptide signaling molecules mainly secreted by insects’ central nervous system (CNS) to reach target organs. A substantial body of research on the role of neuropeptides in regulating mating behaviors in insects has been undertaken. This review aims to (1) synthesize existing knowledge on insect mating behaviors, (2) elucidate the neuropeptidergic mechanisms governing these behaviors, and (3) identify knowledge gaps and propose future research directions. The mating proc

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Chandrasekharan, Bindu, Behtash Ghazi Nezami, and Shanthi Srinivasan. "Emerging neuropeptide targets in inflammation: NPY and VIP." American Journal of Physiology-Gastrointestinal and Liver Physiology 304, no. 11 (2013): G949—G957. http://dx.doi.org/10.1152/ajpgi.00493.2012.

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The enteric nervous system (ENS), referred to as the “second brain,” comprises a vast number of neurons that form an elegant network throughout the gastrointestinal tract. Neuropeptides produced by the ENS play a crucial role in the regulation of inflammatory processes via cross talk with the enteric immune system. In addition, neuropeptides have paracrine effects on epithelial secretion, thus regulating epithelial barrier functions and thereby susceptibility to inflammation. Ultimately the inflammatory response damages the enteric neurons themselves, resulting in deregulations in circuitry an

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Lundy, F. T., and G. J. Linden. "Neuropeptides and Neurogenic Mechanisms in Oral and Periodontal Inflammation." Critical Reviews in Oral Biology & Medicine 15, no. 2 (2004): 82–98. http://dx.doi.org/10.1177/154411130401500203.

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It is generally accepted that the nervous system contributes to the pathophysiology of peripheral inflammation, and a neurogenic component has been implicated in many inflammatory diseases, including periodontitis. Neurogenic inflammation should be regarded as a protective mechanism, which forms the first line of defense and protects tissue integrity. However, severe or prolonged noxious stimulation may result in the inflammatory response mediating injury rather than facilitating repair. This review focuses on the accumulating evidence suggesting that neuropeptides have a pivotal role in the c

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Dr., Mehak Siddiqui Dr. Minahil Munir Dr. Hifza Rehman. "ANALYSIS OF USE OF NEUROPEPTIDES IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PAKISTAN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 10 (2018): 10768–71. https://doi.org/10.5281/zenodo.1470637.

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<strong><em>Introduction: </em></strong><em>Many neuropeptides have recently been identified in human and animal airways. These peptides have potent effects on airway caliber, blood vessels, and secretions, raising the possibility that they may be involved in airway diseases such as asthma. <strong>Objectives of the study: </strong>The basic aim of the study is to analyze the use of neuropeptides in asthma and chronic obstructive pulmonary disease in Pakistan. <strong>Methodology of the study: </strong>This study was conducted at Children Hospital & Institute of Child Health, Multan during

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Lei, Quanxing, Ziming Wang, Shuangyan Yao, et al. "Transcriptome-Wide Identification of Neuropeptides and Neuropeptide Receptors in the Twenty-Eight-Spotted Ladybird Henosepilachna vigintioctopunctata." Insects 16, no. 6 (2025): 624. https://doi.org/10.3390/insects16060624.

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The ladybird beetle, Henosepilachna vigintioctopunctata, is an oligophagous pest with significant economic impact. This pest causes considerable economic damage on numerous Solanaceae crops. Neuropeptides, along with their designated receptors, play a pivotal role in regulating diverse biological processes in insects, presenting a promising avenue for innovative pest management strategies. Herein, the transcriptome of the central nervous system (CNS) of H. vigintioctopunctata was sequenced. Overall, our analysis identified 58 neuropeptide precursor genes, from which 98 diverse mature peptides

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Cajado-Carvalho, Daniela, Cristiane da Silva, Roberto Kodama, et al. "Purification and Biochemical Characterization of TsMS 3 and TsMS 4: Neuropeptide-Degrading Metallopeptidases in the Tityus serrulatus Venom." Toxins 11, no. 4 (2019): 194. http://dx.doi.org/10.3390/toxins11040194.

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Although omics studies have indicated presence of proteases on the Tityus serrulatus venom (TsV), little is known about the function of these molecules. The TsV contains metalloproteases that cleave a series of human neuropeptides, including the dynorphin A (1-13) and the members of neuropeptide Y family. Aiming to isolate the proteases responsible for this activity, the metalloserrulase 3 and 4 (TsMS 3 and TsMS 4) were purified after two chromatographic steps and identified by mass spectrometry analysis. The biochemical parameters (pH, temperature and cation effects) were determined for both

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Edvinsson, L., and PJ Goadsby. "Neuropeptides in the Cerebral Circulation: Relevance to Headache." Cephalalgia 15, no. 4 (1995): 272–76. http://dx.doi.org/10.1046/j.1468-2982.1995.1504272.x.

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The article briefly describes the innervation of the human cerebral circulation by nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gent-related peptide (CGRP). The neuropeptides in human cerebral arteries were characterized by radioimmunoassay in combination with HPLC. These neuropeptides mediate contraction (NPY) and dilatation (VIP, SP, CGRP). In conjunction with spontaneous attacks of migraine or cluster headache, release of CGRP is seen. With the associated symptoms of nasal congestion and rhinorrhea, VIP is released. Succ

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Li, Honghao, Liangzhen Jiang, Kaixiang Yang, Shulin Shang, Mingxin Li, and Zhibin Lv. "iNP_ESM: Neuropeptide Identification Based on Evolutionary Scale Modeling and Unified Representation Embedding Features." International Journal of Molecular Sciences 25, no. 13 (2024): 7049. http://dx.doi.org/10.3390/ijms25137049.

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Neuropeptides are biomolecules with crucial physiological functions. Accurate identification of neuropeptides is essential for understanding nervous system regulatory mechanisms. However, traditional analysis methods are expensive and laborious, and the development of effective machine learning models continues to be a subject of current research. Hence, in this research, we constructed an SVM-based machine learning neuropeptide predictor, iNP_ESM, by integrating protein language models Evolutionary Scale Modeling (ESM) and Unified Representation (UniRep) for the first time. Our model utilized

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Taghert, Paul H. "FMRFamide neuropeptides and neuropeptide-associated enzymes inDrosophila." Microscopy Research and Technique 45, no. 2 (1999): 80–95. http://dx.doi.org/10.1002/(sici)1097-0029(19990415)45:2<80::aid-jemt3>3.0.co;2-x.

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Kuspiel, Sven, Dominik Wiemuth, and Stefan Gründer. "The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a)." Biomolecules 11, no. 4 (2021): 571. http://dx.doi.org/10.3390/biom11040571.

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Acid-sensing ion channels (ASICs) are ionotropic receptors that are directly activated by protons. Although protons have been shown to act as a neurotransmitter and to activate ASICs during synaptic transmission, it remains a possibility that other ligands directly activate ASICs as well. Neuropeptides are attractive candidates for alternative agonists of ASICs, because related ionotropic receptors are directly activated by neuropeptides and because diverse neuropeptides modulate ASICs. Recently, it has been reported that the neuropeptide nocistatin directly activates ASICs, including ASIC1a.

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