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Dissertations / Theses on the topic 'Novel non-coding regulator RNA'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Pettini, Tom. "The role of novel long non-coding RNAs in Hox gene regulation." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-novel-long-noncoding-rnas-in-hox-gene-regulation(c8e44900-3ac0-40be-8ec6-b50179381d17).html.

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Whole genome transcriptome analysis has revealed that a large proportion of the genome in higher metazoa is transcribed, yet only a small proportion of this transcription is protein-coding. One possible function of non-coding transcription is that it enables complex and diverse body plans to evolve through variation in deployment of a relatively common set of protein-coding genes. Functional studies suggest that long non-coding RNAs (lncRNAs) regulate gene expression via diverse mechanisms, operating in both cis and trans to activate or repress target genes. An emerging theme common to lncRNA

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Chong, Vanessa. "Biotagging, a genetically encoded toolkit in the zebrafish, reveals novel non-coding RNA players during neural crest and myocardium development." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:26b7d1a0-3f03-4518-97c4-566cc5d5bf02.

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Complex multicellular organisms are composed of at least 200 cell types, which contain the same DNA "black box" of genetic information. It is the precise regime according to which they express their genes, exquisitely controlled by gene regulatory circuits, that defines their cellular identity, morphology and function. We have developed an in vivo biotinylation method that uses genetically encoded components in zebrafish, termed biotagging, for genome-wide regulatory analysis of defined embryonic cell populations. By labelling selected proteins in specific cell types, biotagging eliminates bac

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3

Chang, Yueming. "Investigation of two early events in amyotrophic lateral sclerosis mRNA oxidation and up-regulation of a novel protective factor MSUR1 /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1196182155.

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4

de, Bony Eric James. "Novel insights into the function and regulation of coding and long non-coding RNAs." Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/268600.

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Le dogme central de la biologie repose sur la production de protéines à partir de notre ADN. L’ADN est d’abord transcrit en ARN et celui-ci est ensuite traduit en protéine. C’est donc en cette dernière qu’est localisé le “pouvoir exécutif” de la cellule, ce qui explique le fait que les protéines soient devenues le centre d’attention de la recherche. L’ARN, quant à lui, est donc depuis longtemps considéré comme une molécule intermédiaire, dont l’unique raison d’être est le transfert d’information entre l’ADN et les protéines. Pourtant, ces dernières années, les avancées technologiques ont révél

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Han, Xiao. "Interaction of the non coding RNA 7SK, a regulator of human transcription elongation, with the LaRP7 protein." Electronic Thesis or Diss., Paris Sciences et Lettres (ComUE), 2016. http://www.theses.fr/2016PSLEE008.

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L’ARN non-codant 7SK forme la charpente d’un complexe, 7SK snRNP, qui régule l’activité du facteur d’élongation de la transcription P-TEFb, intervenant dans la levée des pauses transcriptionelles chez les métazoaires. Le 7SK snRNP comprend les protéines LARP7, essentielle pour la stabilité de l’ARN 7SK et MePCE, participant à sa coiffe. Dans le cadre d’une investigation du rapport entre structure et fonction de l’ARN7SK, le projet était de comprendre commen la protéine LARP7 reconnait et assemble l’ARN dans le 7SK snRNP. La protéine LARP7, membre d’une famille reliée à laprotéine La, est spéci

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Han, Xiao. "Interaction of the non coding RNA 7SK, a regulator of human transcription elongation, with the LaRP7 protein." Thesis, Paris Sciences et Lettres (ComUE), 2016. http://www.theses.fr/2016PSLEE008/document.

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L’ARN non-codant 7SK forme la charpente d’un complexe, 7SK snRNP, qui régule l’activité du facteur d’élongation de la transcription P-TEFb, intervenant dans la levée des pauses transcriptionelles chez les métazoaires. Le 7SK snRNP comprend les protéines LARP7, essentielle pour la stabilité de l’ARN 7SK et MePCE, participant à sa coiffe. Dans le cadre d’une investigation du rapport entre structure et fonction de l’ARN7SK, le projet était de comprendre commen la protéine LARP7 reconnait et assemble l’ARN dans le 7SK snRNP. La protéine LARP7, membre d’une famille reliée à laprotéine La, est spéci

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7

Peters, Rosie Elizabeth. "Identifying novel targets for the snoRNA class of stable non-coding RNAs." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33123.

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Non-coding RNAs (ncRNAs) are a subset of RNAs that do not code for protein. They are divided into a number of different groups based on their function and targets. Small nucleolar RNAs (snoRNAs) are ncRNAs that have long been known to function as guides for ribosomal RNA (rRNA) modifying enzymes. They are classified into two major groups: box C/D snoRNAs and box H/ACA snoRNAs. Most box C/D snoRNAs direct the 2'-O-methylation of rRNA substrates, but some lack known targets and are therefore termed 'orphan snoRNAs'. Studies have implicated orphan snoRNAs in pre-mRNA processing and stability, but

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Niemczyk, Malwina. "Epigenetic and transcriptional relationship between a novel long non-coding RNA GNG12-AS1 and imprinted DIRAS3." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708234.

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9

Zhang, Zhouwei. "Investigation of DNA and RNA markers by novel technologies demonstrates DNA content intratumoral heterogeneity and long non-coding RNA aberrations in breast tumors." ScholarWorks @ UVM, 2014. https://scholarworks.uvm.edu/graddis/323.

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BACKGROUND: Breast cancer is the most commonly diagnosed cancer and second leading cancer death cause among females in the U.S.A. About 1 in 8 women in U.S will develop invasive breast cancer over the course of her lifetime. In 2013, 234,580 new invasive breast cancer cases are expected to occur in women within the US and approximately 64,640 non-invasive carcinomas in situ were diagnosed in 2013, most of which were ductal carcinoma in situ (DCIS). Along with technological advances, a wide variety of candidate biomarkers have been proposed for cancer diagnosis and prognosis, including DNA cont

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10

Kacharia, Fenil Rashmin. "Investigating the Origin and Functions of a Novel Small RNA in Escherichia coli." PDXScholar, 2016. http://pdxscholar.library.pdx.edu/open_access_etds/3106.

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Non-coding small RNAs (sRNAs) regulate various cellular processes in bacteria. They bind to a chaperone protein Hfq for stability and regulate gene expression by base-pairing with target mRNAs. Although the importance of sRNAs in bacteria has been well established, the mode of origination of novel sRNA genes is still elusive, mainly because the rapid rate of evolution of sRNAs obscures their original sources. To overcome this impediment, we identified a recently formed sRNA (EcsR2) in E. coli, and show that it evolved from a degraded bacteriophage gene. Our analyses also revealed that young sR

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11

Zhang, Shaoyan. "Overexpression of the Turnip Crinkle Virus Replicase Exerts Opposite Effects on the Synthesis of Viral Genomic RNA and a Novel Viral Long Non-Coding RNA." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1595258672390499.

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Dumbović, Gabrijela 1986. "Molecular and mechanistic characterization of a novel long non-coding RNA derived from NBL2 macrosatellite repeats in colorectal cancer." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/523517.

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DNA hypomethylation of repeats has been found in almost every tumor type studied. Hypomethylation of repetitive elements was shown to increase the likelihood of homologous recombination of these repeated sequences and thus contribute to genome instability. In our group we have found a macrosatellite repeat called NBL2 hypomethylated in a subset of colorectal cancers (CRCs). NBL2 somatic hypomethylation in CRC associated with genomic damage, especially in tumors having wild type P53. Here, we describe the genomic location of NBL2 by thorough in silico analysis, metaphase FISH and PCR on DNA fr

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13

Krzywkowski, Tomasz. "iLocks: a novel tool for RNA assays with improved specificity." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-147734.

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The Central Dogma of molecular biology describes a framework for how genetic information is transferred in cells, placing RNA as a messenger between DNA and translated proteins. During the last years, interest in RNA research has grown tremendously due to the increasing understanding and recognition of the importance of RNA in regulation of gene expression, biochemical catalysis, and genome integrity surveillance. Most importantly, RNA content, unlike DNA, changes constantly, fine-tuning the cellular response to match the environmental conditions. There is a clear potential for RNA biomarkers,

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14

Ghini, F. "THE PLASTICITY OF MIRNA POOL: A NOVEL APPROACH TO REVEAL MECHANISMS BEHIND MIRNA TURNOVER." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/466760.

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MicroRNAs (miRNAs) are a small (18-25nt long), evolutionary conserved, class of non-coding RNAs that appears as a major regulatory component of gene expression, implicated in virtually all known physiological and pathological processes. They act at post-transcriptional level by silencing the expression of a multitude of target mRNAs through various mechanisms, including target degradation and protein synthesis inhibition. As a result, the regulation of the miRNA pool is one of the critical events in the definition of cell identity and behavior both in physiology and disease. Although large ef

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15

Hochschartner, Gerald. "Revealing the past : the potential of a novel small nucleolar RNA (snoRNA) marker system for studying plant evolution." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1695.

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Despite the existence of various molecular marker systems there are still limitations in distinguishing between closely related species based on molecular divergence, especially when hybridization events have occurred in the past. The characterisation of plant small nucleolar RNA (snoRNA) genes and their organisation into multigene clusters provides a potential nuclear marker system which could help in resolving the phylogenetic history of plants and might be applicable in DNA barcoding. Using closely and distantly related Senecio species, I investigated a combination of fragment length and se

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16

Pantano, Rubiño Lorena. "Full characterization of the small RNA transcriptome using novel computational methods for high-throughput sequencing data: study of miRNA variability in eukaryote organisms." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/53576.

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In this thesis we have developed a user-friendly tool, SeqBuster, for the analysis of small RNA (sRNA) data generated by next generation sequencing strategies, with special emphasis on deep characterization of miRNA variants (isomiRs). We tested the tool using public datasets, revealing an unexpected amount of isomiRs in the total miRNA profile in different species. In addition, we detected all known classes of non-miRNA sRNAs and new sRNAs with a still unassigned function. Furthermore, we studied the implication of miRNAs and isomiRs in human brain development and aging and in Huntingt

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Lerch, Maike Franziska [Verfasser], Wilma [Gutachter] Ziebuhr, Knut [Gutachter] Ohlsen, Martin [Gutachter] Fraunholz, and Cynthia [Gutachter] Sharma. "Characterisation of a novel non-coding RNA and its involvement in polysaccharide intercellular adhesin (PIA)-mediated biofilm formation of \(Staphylococcus\) \(epidermidis\) / Maike Franziska Lerch ; Gutachter: Wilma Ziebuhr, Knut Ohlsen, Martin Fraunholz, Cynthia Sharma." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1174143444/34.

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18

Li, Yanhui. "Construction and Analysis of a Genome-Wide Insertion Library in Schizosaccharomyces pombe Reveals Novel Aspects of DNA Repair." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1413927620.

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19

Albesher, Nour H. "A Novel Non-coding RNA Regulates Drought Stress Tolerance in Arabidopsis thaliana." Thesis, 2014. http://hdl.handle.net/10754/316607.

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Drought (soil water deficit) as a major adverse environmental condition can result in serious reduction in plant growth and crop production. Plants respond and adapt to drought stresses by triggering various signalling pathways leading to physiological, metabolic and developmental changes that may ultimately contribute to enhanced tolerance to the stress. Here, a novel non-coding RNA (ncRNA) involved in plant drought stress tolerance was identified. We showed that increasing the expression of this ncRNA led to enhanced sensitivity during seed germination and seedling growth to the phytohormone

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Di, Cecilia Serena. "A Novel Long Non-Coding RNA Transcript Regulates The Fate of Colon Cancer Initiation." Tesi di dottorato, 2015. http://www.fedoa.unina.it/10058/1/Di%20Cecilia.pdf.

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Cancer Initiating cells are a small population of cancer cells capable of tumor initiation and growth. Characteristic of these cells are the expression of “stem-like” markers and the common alteration of the Wnt/β-catenin and Notch pathways. In my thesis, I characterized Colon Cancer Initiating Cells (CCICs) by FACS analysis from HT-29 colon cancer cell line. I then performed in vitro colonospheres-forming assay and RNA-Seq, to interrogate the genome-wide signature involving CCICs. My results show that members of Wnt/β-catenin pathway are elevated in CCICs and colonospheres, when compared to a

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21

Lee, Ya-Chiao, and 李亞橋. "Discovery of a Novel Regulatory Role of the Small Non-Coding RNA DsrA in E. coli." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/05036216900707652710.

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碩士<br>國立陽明大學<br>生命科學暨基因體科學研究所<br>99<br>Several small non-coding RNAs (sRNAs) have been identified in E. coli that act by various mechanisms and are involved in a wide range of physiological responses. The majority of sRNAs characterized to date interact with mRNA targets by base pairing, having either extensive (cis-encoded) or limited (trans-encoded) complementarities with their targets. Although sRNAs are involved in transcriptional regulation, they primarily act on their targets at the post-transcriptional level, which may result in destabilization or stabilization of mRNAs. Here we discove

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"Functional characteristics of a novel Alu-originated non-coding RNA, TIFm71." 2014. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1291695.

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Zhang, Li.<br>Thesis Ph.D. Chinese University of Hong Kong 2014.<br>Includes bibliographical references (leaves 192-207).<br>Abstracts also in Chinese.<br>Title from PDF title page (viewed on 04, November, 2016).

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Credendino, Sara Carmela. "Characterization of a Novel Long Non-coding RNA Involved in Thyroid Differentiation." Tesi di dottorato, 2017. http://www.fedoa.unina.it/11541/7/CredendinoFedoa.pdf.

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Thyroid is the endocrine gland that most frequently undergoes to congenital disorders or neoplastic transformation and despite its organogenesis is well characterized, molecular bases of early thyroid differentiation are still obscure. During last years, long non-coding RNAs (lncRNA) have acquired increasing relevance in many biological processes, such as differentiation and cancer. In E10.5 mouse thyroid bud the most enriched transcript resulted to be a poorly characterized lncRNA, that we named Thybe1 (thyroid bud enriched 1). Thybe1 is an antisense transcript of the protein-coding gene klhl

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"Identification and Functional Characterization of Novel Long Non-coding RNAs Regulated by Enhancer of Zest Homolog 2 in Hepatocellular Carcinoma." 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292181.

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背景及目的：EZH2是PRC2的核心單元，其作用是抑制下游基因的轉錄。EZH2在肝細胞癌(HCC)中過度表達，因此有必要研究其在致癌網絡中的作用機理。受EZH2調控的蛋白質編碼基因研究較多而其他因子例如長鏈非編碼RNA(lncRNAs)研究較少。lncRNAs在組織及癌症中特異性表達，表明了其在癌症中起到了關鍵作用。lncRNAs在HCC腫瘤中表達異常，對導致其表達失調的機制所知甚少。之前有研究EZH2和lncRNAs的相互作用，但受EZH2調控的lncRNAs則鮮有報道。因此，我們的目標就是鑒定受EZH2調控的lncRNAs并探索它們在HCC中的作用。<br>方法：我們用EZH2抑制劑DZnep處理了Hep3B細胞，然後對全基因組的lncRNAs進行定量分析。并測量受DZnep處理后上調以及下調最明顯的lncRNAs在HCC細胞以及臨床樣本中的表達，進一步篩選出候選lncRNAs。通過敲降及過表達來研究生物功能。基因芯片微陣列分析揭示了候選lncRNAs的下游相關基因以及信號通路。同時，我們鑒定并研究了這些lncRNAs的結合蛋白。<br>結果：兩種受EZH2調控的lncRNA被鑒定出來并分別命名為DN2和DN5。DN2和DN5在HCC臨床樣本及多數的HCC細胞系中表達量顯著下降。細胞功能學實驗證明，抑制DN2和DN5表达,可以促進細胞生長，細胞存活能力，轉化能力以及体内腫瘤形成

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25

Chen, You-Zuo, and 陳宥佐. "Anti-diabetic drug inhibits gastric cancer cell proliferation and metastasis by regulating a novel long-non coding RNA Loc100506691." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/11648733592677447663.

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碩士<br>義守大學<br>生物科技學系<br>104<br>The long-non coding RNAs (lncRNAs) are a group of non-protein coding transcripts, which are more than 200 nucleotides in length. Accumulating evidences showed that lncRNAs play critical role in cancer progression, including cell growth, cell cycle, apoptosis and metastasis. Metformin shows the potential as a preventive and therapeutic drug for human cancers. Previous studies indicated that metformin suppressed cancer cerll growth by regulating protein coding genes and microRNAs (miRNA). However, the role of lncRNA involved in metformin-induced inhibition of cell

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Lerch, Maike Franziska. "Characterisation of a novel non-coding RNA and its involvement in polysaccharide intercellular adhesin (PIA)-mediated biofilm formation of \(Staphylococcus\) \(epidermidis\)." Doctoral thesis, 2018. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-155777.

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Coagulase-negative staphylococci, particularly Staphylococcus epidermidis, have been recognised as an important cause of health care-associated infections due to catheterisation, and livestock-associated infections. The colonisation of indwelling medical devices is achieved by the formation of biofilms, which are large cell-clusters surrounded by an extracellular matrix. This extracellular matrix consists mainly of PIA (polysaccharide intercellular adhesin), which is encoded by the icaADBC-operon. The importance of icaADBC in clinical strains provoking severe infections initiated numerous inve

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