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Journal articles on the topic 'Novel non-coding regulator RNA'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sevilla, Emma, Beatriz Martín-Luna, Andrés González, Jesús A. Gonzalo-Asensio, María Luisa Peleato, and María F. Fillat. "Identification of three novel antisense RNAs in the fur locus from unicellular cyanobacteria." Microbiology 157, no. 12 (2011): 3398–404. http://dx.doi.org/10.1099/mic.0.048231-0.

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The interplay between Fur (ferric uptake regulator) proteins and small, non-coding RNAs has been described as a key regulatory loop in several bacteria. In the filamentous cyanobacterium Anabaena sp. PCC 7120, a large dicistronic transcript encoding the putative membrane protein Alr1690 and an α-furA RNA is involved in the modulation of the global regulator FurA. In this work we report the existence of three novel antisense RNAs in cyanobacteria and show that a cis α-furA RNA is conserved in very different genomic contexts, namely in the unicellular cyanobacteria Microcystis aeruginosa PCC 780

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Schneider, Marius, and Peter B. Becker. "Nicht-codierende RNA als Regulator der Neurogenese." BIOspektrum 29, no. 1 (2023): 35–37. http://dx.doi.org/10.1007/s12268-023-1891-1.

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AbstractLong, non-coding (Inc) RNAs emerge as crucial regulators of gene expression. Their ability to interact with DNA and protein mediates the recruitment of regulators to defined chromosomal loci. LncRNAs are particularly abundant in brain tissues where they are involved in cell specification. We described a novel lncRNA, RUS (RNA upstream to Slitrk3), which interacts with epigenetic regulators and contributes to shaping the gene expression program of neural precursor cells towards neurogenesis.

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Limberis, Jason D., Alina Nalyvayko, Joel D. Ernst, and John Z. Metcalfe. "selSeq: A method for the enrichment of non-polyadenylated RNAs including enhancer and long non-coding RNAs for sequencing." PLOS ONE 18, no. 11 (2023): e0289442. http://dx.doi.org/10.1371/journal.pone.0289442.

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Non-polyadenylated RNA includes a large subset of crucial regulators of RNA expression and constitutes a substantial portion of the transcriptome, playing essential roles in gene regulation. For example, enhancer RNAs are long non-coding RNAs that perform enhancer-like functions, are bi-directionally transcribed, and usually lack polyA tails. This paper presents a novel method, selSeq, that selectively removes mRNA and pre-mRNA from samples enabling the selective sequencing of crucial regulatory elements, including non-polyadenylated RNAs such as long non-coding RNA, enhancer RNA, and non-cano

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4

Li, Siqi, Zhengping Xu, and Jinghao Sheng. "tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA." Genes 9, no. 5 (2018): 246. http://dx.doi.org/10.3390/genes9050246.

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Kuai, Zheng, Meiting Chen, yang yu, Fan Yang, and chunxiang Zhang. "UP-REGULATION OF LONG NON-CODING RNA MORBID ATTENUATES SENESCENCE." Innovation in Aging 3, Supplement_1 (2019): S90. http://dx.doi.org/10.1093/geroni/igz038.344.

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Abstract Aging is the inevitable, irreversible decline in function on the cellular and organ level leading to increased incidence of the most frequent diseases such as cancer and cardiovascular disease, that occurs over time. whereas the molecular mechanisms of senescence remain largely unknown. Here we identified that a novel long noncoding RNA, Morrbid was significantly decreased in different organs of aged mice, such as heart, liver, spleen, lung, kidney and brain. Interestingly, the telomeres length of Morrbid KO mice were significantly shorted than the WT mice at the same age. We also fou

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Ma, Ning, Lingyun Zhou, Yanfen Zhang, Yuting Jiang, and Xu Gao. "Intragenic microRNA and long non-coding RNA: novel potential regulator ofIGF2-H19imprinting region." Evolution & Development 16, no. 1 (2014): 1–2. http://dx.doi.org/10.1111/ede.12057.

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Rossi, Francesca, Alvaro Centrón-Broco, Dario Dattilo, et al. "CircVAMP3: A circRNA with a Role in Alveolar Rhabdomyosarcoma Cell Cycle Progression." Genes 12, no. 7 (2021): 985. http://dx.doi.org/10.3390/genes12070985.

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Circular RNAs (circRNAs), a class of covalently closed RNAs formed by a back-splicing reaction, have been involved in the regulation of diverse oncogenic processes. In this article we describe circVAMP3, a novel circular RNA overexpressed in RH4, a representative cell line of alveolar rhabdomyosarcoma. We demonstrated that circVAMP3 has a differential m6A pattern opposed to its linear counterpart, suggesting that the two isoforms can be differently regulated by such RNA modification. Moreover, we show how circVAMP3 depletion in alveolar rhabdomyosarcoma cells can impair cell cycle progression,

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Greene, J. P., G. Blackshields, O. Casey, et al. "circular RNA: A novel regulatory non-coding RNA expressed in prostate cancer." Annals of Oncology 27 (October 2016): vi531. http://dx.doi.org/10.1093/annonc/mdw392.17.

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9

Zhu, Min, Xiao Li, Shengtao Zhu, Peng Li, Li Min, and Shutian Zhang. "Long non-coding RNA BLACAT1, a novel promising biomarker and regulator of human cancers." Biomedicine & Pharmacotherapy 132 (December 2020): 110808. http://dx.doi.org/10.1016/j.biopha.2020.110808.

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Porozhan, Yevheniia, Mikkel Carstensen, Sandrine Thouroude, et al. "Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis." Life Science Alliance 7, no. 10 (2024): e202402586. http://dx.doi.org/10.26508/lsa.202402586.

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HP1α/CBX5 is an epigenetic regulator with a suspected role in multiple sclerosis (MS). Here, using high-depth RNA sequencing on monocytes, we identified a subset of MS patients with reduced CBX5 expression, correlating with progressive stages of the disease and extensive transcriptomic alterations. Examination of rare non-coding RNA species in these patients revealed impaired maturation/degradation of U snRNAs and enhancer RNAs, indicative of reduced activity of the Integrator, a complex with suspected links to increased MS risk. At protein-coding genes, compromised Integrator activity manifes

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Arafat, Maram, and Ruth Sperling. "Crosstalk between Long Non-Coding RNA and Spliceosomal microRNA as a Novel Biomarker for Cancer." Non-Coding RNA 9, no. 4 (2023): 42. http://dx.doi.org/10.3390/ncrna9040042.

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Non-coding RNAs (ncRNAs) play diverse roles in regulating cellular processes and have been implicated in pathological conditions, including cancer, where interactions between ncRNAs play a role. Relevant here are (i) microRNAs (miRNAs), mainly known as negative regulators of gene expression in the cytoplasm. However, identification of miRNAs in the nucleus suggested novel nuclear functions, and (ii) long non-coding RNA (lncRNA) regulates gene expression at multiple levels. The recent findings of miRNA in supraspliceosomes of human breast and cervical cancer cells revealed new candidates of lnc

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Otsubo, Yoko, Yoshiaki Kamada, and Akira Yamashita. "Novel Links between TORC1 and Traditional Non-Coding RNA, tRNA." Genes 11, no. 9 (2020): 956. http://dx.doi.org/10.3390/genes11090956.

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Target of rapamycin (TOR) is a serine/threonine kinase that modulates cell growth and metabolism in response to environmental changes. Transfer RNA (tRNA) is an abundant and ubiquitous small non-coding RNA that is essential in the translation of mRNAs. Beyond its canonical role, it has been revealed that tRNAs have more diverse functions. TOR complex 1 (TORC1), which is one of the two TOR complexes, regulates tRNA synthesis by controlling RNA polymerase III. In addition to tRNA synthesis regulation, recent studies have revealed hidden connections between TORC1 and tRNA, which are both essentia

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Cantarella, Simona, Elena Di Nisio, Davide Carnevali, Giorgio Dieci, and Barbara Montanini. "Interpreting and integrating big data in non-coding RNA research." Emerging Topics in Life Sciences 3, no. 4 (2019): 343–55. http://dx.doi.org/10.1042/etls20190004.

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Abstract In the last two decades, we have witnessed an impressive crescendo of non-coding RNA studies, due to both the development of high-throughput RNA-sequencing strategies and an ever-increasing awareness of the involvement of newly discovered ncRNA classes in complex regulatory networks. Together with excitement for the possibility to explore previously unknown layers of gene regulation, these advancements led to the realization of the need for shared criteria of data collection and analysis and for novel integrative perspectives and tools aimed at making biological sense of very large bo

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Kaliatsi, Eleni G., Nikoleta Giarimoglou, Constantinos Stathopoulos, and Vassiliki Stamatopoulou. "Non-Coding RNA-Driven Regulation of rRNA Biogenesis." International Journal of Molecular Sciences 21, no. 24 (2020): 9738. http://dx.doi.org/10.3390/ijms21249738.

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Ribosomal RNA (rRNA) biogenesis takes place in the nucleolus, the most prominent condensate of the eukaryotic nucleus. The proper assembly and integrity of the nucleolus reflects the accurate synthesis and processing of rRNAs which in turn, as major components of ribosomes, ensure the uninterrupted flow of the genetic information during translation. Therefore, the abundant production of rRNAs in a precisely functional nucleolus is of outmost importance for the cell viability and requires the concerted action of essential enzymes, associated factors and epigenetic marks. The coordination and re

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Dong, Rui, Xiang-Qi Liu, Bin-Bin Zhang, Bai-Hui Liu, Shan Zheng, and Kui-Ran Dong. "Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma." Oncotarget 8, no. 26 (2017): 42087–97. http://dx.doi.org/10.18632/oncotarget.14992.

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Zeng, Xianhui, Xianglei Yuan, Qiuyu Cai, Chengwei Tang, and Jinhang Gao. "Circular RNA as An Epigenetic Regulator in Chronic Liver Diseases." Cells 10, no. 8 (2021): 1945. http://dx.doi.org/10.3390/cells10081945.

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Circular RNA (circRNA) is a type of non-coding RNA characterized by a covalently closed continuous loop. CircRNA is generated by pre-mRNA through back-splicing and is probably cleared up by extracellular vesicles. CircRNAs play a pivotal role in the epigenetic regulation of gene expression at transcriptional and post-transcriptional levels. Recently, circRNAs have been demonstrated to be involved in the regulation of liver homeostasis and diseases. However, the epigenetic role and underlying mechanisms of circRNAs in chronic liver diseases remain unclear. This review discussed the role of circ

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Damas, Nkerorema Djodji, Nicolas Fossat, and Troels K. H. Scheel. "Functional Interplay between RNA Viruses and Non-Coding RNA in Mammals." Non-Coding RNA 5, no. 1 (2019): 7. http://dx.doi.org/10.3390/ncrna5010007.

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Exploring virus–host interactions is key to understand mechanisms regulating the viral replicative cycle and any pathological outcomes associated with infection. Whereas interactions at the protein level are well explored, RNA interactions are less so. Novel sequencing methodologies have helped uncover the importance of RNA–protein and RNA–RNA interactions during infection. In addition to messenger RNAs (mRNAs), mammalian cells express a great number of regulatory non-coding RNAs, some of which are crucial for regulation of the immune system whereas others are utilized by viruses. It is thus b

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Zhang, Pengpeng, Zhe Chao, Rui Zhang, et al. "Circular RNA Regulation of Myogenesis." Cells 8, no. 8 (2019): 885. http://dx.doi.org/10.3390/cells8080885.

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Circular RNA (circRNA) is a novel class of non-coding RNA generated by pre-mRNA back splicing, which is characterized by a closed-loop structure. Although circRNAs were firstly reported decades ago, their regulatory roles have not been discovered until recently. In this review, we discussed the putative biogenesis pathways and regulatory functions of circRNAs. Recent studies showed that circRNAs are abundant in skeletal muscle tissue, and their expression levels are regulated during muscle development and aging. We, thus, characterized the expression profile of circRNAs in skeletal muscle and

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Tang, Qing, and Swei Sunny Hann. "HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer." Cellular Physiology and Biochemistry 47, no. 3 (2018): 893–913. http://dx.doi.org/10.1159/000490131.

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Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to b

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Li, Meixia, Shengyun Wen, Xiangqian Guo, et al. "The novel long non-coding RNA CRG regulates Drosophila locomotor behavior." Nucleic Acids Research 40, no. 22 (2012): 11714–27. http://dx.doi.org/10.1093/nar/gks943.

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Oo, James A., Ralf P. Brandes, and Matthias S. Leisegang. "Long non-coding RNAs: novel regulators of cellular physiology and function." Pflügers Archiv - European Journal of Physiology 474, no. 2 (2021): 191–204. http://dx.doi.org/10.1007/s00424-021-02641-z.

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AbstractLong non-coding RNAs were once considered as “junk” RNA produced by aberrant DNA transcription. They are now understood to play central roles in diverse cellular processes from proliferation and migration to differentiation, senescence and DNA damage control. LncRNAs are classed as transcripts longer than 200 nucleotides that do not encode a peptide. They are relevant to many physiological and pathophysiological processes through their control of fundamental molecular functions. This review summarises the recent progress in lncRNA research and highlights the far-reaching physiological

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Samara, Vishnu Amaram, Sadhan Das, Marpadga A. Reddy, et al. "Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells." Cells 10, no. 10 (2021): 2696. http://dx.doi.org/10.3390/cells10102696.

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Long non-coding RNAs (lncRNAs) play key roles in Angiotensin II (AngII) signaling but their role in chondrogenic transformation of vascular smooth muscle cells (VSMCs) is unknown. We describe a novel AngII-induced lncRNA Alivec (Angiotensin II-induced lncRNA in VSMCs eliciting chondrogenic phenotype) implicated in VSMC chondrogenesis. In rat VSMCs, Alivec and the nearby gene Acan, a chondrogenic marker, were induced by growth factors AngII and PDGF and the inflammatory cytokine TNF-α. AngII co-regulated Alivec and Acan through the activation of AngII type1 receptor signaling and Sox9, a master

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Bink, Diewertje, Noelia Lozano-Vidal, and Reinier Boon. "Long Non-Coding RNA in Vascular Disease and Aging." Non-Coding RNA 5, no. 1 (2019): 26. http://dx.doi.org/10.3390/ncrna5010026.

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Cardiovascular diseases are the most prominent cause of death in Western society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging an

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Ala, Ugo. "Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story." Cells 9, no. 7 (2020): 1574. http://dx.doi.org/10.3390/cells9071574.

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MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and non-coding RNA molecules can be targeted by the same miRNAs and can indirectly regulate each other by competing for them. These RNAs, otherwise known as competing endogenous RNAs (ceRNAs), lead to an additional post-transcriptional regulatory layer, where non-coding RNAs can find n

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Potnis, Manali, and Christian Sell. "An Evolving Role for the Long Non-Coding RNA H19 in Aging and Senescence." Innovation in Aging 5, Supplement_1 (2021): 561. http://dx.doi.org/10.1093/geroni/igab046.2153.

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Abstract The long non-coding RNA (lncRNA) H19 is a maternally imprinted gene transcript that, in conjunction with the neighboring Igf2 gene, is critical in controlling embryonic growth. Loss of H19 results in fetal overgrowth associated with Beckwith Weidemann syndrome, while elevated H19 occurs in human cancers. In the adult, H19 functions in cancer cells where it promotes migration and is correlated with poor prognosis, and in adult stem cells where it is a key regulator of cell fate decisions during differentiation. While the function of H19 in primary somatic cells has not been defined, a

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Riaz, Farooq, and Dongmin Li. "Non-coding RNA Associated Competitive Endogenous RNA Regulatory Network: Novel Therapeutic Approach in Liver Fibrosis." Current Gene Therapy 19, no. 5 (2019): 305–17. http://dx.doi.org/10.2174/1566523219666191107113046.

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Liver fibrosis or scarring is the most common pathological feature caused by chronic liver injury, and is widely considered one of the primary causes of morbidity and mortality. It is primarily characterised by hepatic stellate cells (HSC) activation and excessive extracellular matrix (ECM) protein deposition. Overwhelming evidence suggests that the dysregulation of several noncoding RNAs (ncRNAs), mainly long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs) contributes to the activation of HSC and progression of liver fibrosis. These ncRNAs not only bind to their tar

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Li, Wen, Rui Wang, Jie-yi Ma, et al. "A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway." Cellular Physiology and Biochemistry 43, no. 3 (2017): 1152–67. http://dx.doi.org/10.1159/000481756.

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Background/Aims: ALT1 is a novel long non-coding RNA derived from the alternatively spliced transcript of the deleted in lymphocytic leukemia 2 (DLEU2). To date, ALT1 biological roles in human vascular endothelial cells have not been reported. Methods: ALT1 was knocked down by siRNAs. Cell proliferation was analyzed by cck-8. The existence and sequence of human ALT1 were identified by 3’ rapid amplification of cDNA ends. The interaction between lncRNA and proteins was analyzed by RNA-Protein pull down assay, RNA immunoprecipitation, and mass spectrometry analysis. Results: ALT1 was expressed i

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Wu, Yuting, Xiao Liu, Yonghui Fan, et al. "MiR-34b Regulates Muscle Growth and Development by Targeting SYISL." Cells 14, no. 5 (2025): 379. https://doi.org/10.3390/cells14050379.

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Non-coding genes, such as microRNA and lncRNA, which have been widely studied, play an important role in the regulatory network of skeletal muscle development. However, the functions and mechanisms of most non-coding RNAs in skeletal muscle regulatory networks are unclear. This study investigated the function and mechanism of miR-34b in muscle growth and development. MiR-34b overexpression and interference tests were performed in C2C12 myoblasts and animal models. It was demonstrated that miR-34b significantly promoted mouse muscle growth and development in vivo, while miR-34b inhibited myobla

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Orro, Alessandro, and Gabriele A. Trombetti. "High-Accuracy ncRNA Function Prediction via Deep Learning Using Global and Local Sequence Information." Biomedicines 11, no. 6 (2023): 1631. http://dx.doi.org/10.3390/biomedicines11061631.

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The prediction of the biological function of non-coding ribonucleic acid (ncRNA) is an important step towards understanding the regulatory mechanisms underlying many diseases. Since non-coding RNAs are present in great abundance in human cells and are functionally diverse, developing functional prediction tools is necessary. With recent advances in non-coding RNA biology and the availability of complete genome sequences for a large number of species, we now have a window of opportunity for studying non-coding RNA biology. However, the computational methods used to predict the non-coding RNA fu

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Xu, Huimin, Bo Chen, Yuanyuan Zhao, et al. "Non-Coding RNA Analyses of Seasonal Cambium Activity in Populus tomentosa." Cells 11, no. 4 (2022): 640. http://dx.doi.org/10.3390/cells11040640.

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Non-coding RNA, known as long non-coding RNA (lncRNA), circular RNA (circRNA) and microRNA (miRNA), are taking part in the multiple developmental processes in plants. However, the roles of which played during the cambium activity periodicity of woody plants remain poorly understood. Here, lncRNA/circRNA-miRNA-mRNA regulatory networks of the cambium activity periodicity in Populus tomentosa was constructed, combined with morphologic observation and transcriptome profiling. Light microscopy and Periodic Acid Schiff (PAS) staining revealed that cell walls were much thicker and number of cell laye

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Abba, Martin C., Romina Canzoneri, Agustina Gurruchaga, et al. "LINC00885 a Novel Oncogenic Long Non-Coding RNA Associated with Early Stage Breast Cancer Progression." International Journal of Molecular Sciences 21, no. 19 (2020): 7407. http://dx.doi.org/10.3390/ijms21197407.

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Long intergenic non-protein coding RNA 885 (LINC00885) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling pathways modulated by LINC00885 in non-invasive and invasive breast cancer models. We determined that LINC00885 induces premalignant phenotypic changes by increasing cell proliferation, motility, migration and altering 3D growth in normal and DCIS breast cell lines. Transcriptomic studies (RNA-seq) identified the main signaling pathways modulated by LINC00885, which include bi

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Silvestris, Domenico Alessandro, Chiara Scopa, Sara Hanchi, Franco Locatelli, and Angela Gallo. "De Novo A-to-I RNA Editing Discovery in lncRNA." Cancers 12, no. 10 (2020): 2959. http://dx.doi.org/10.3390/cancers12102959.

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Background: Adenosine to inosine (A-to-I) RNA editing is the most frequent editing event in humans. It converts adenosine to inosine in double-stranded RNA regions (in coding and non-coding RNAs) through the action of the adenosine deaminase acting on RNA (ADAR) enzymes. Long non-coding RNAs, particularly abundant in the brain, account for a large fraction of the human transcriptome, and their important regulatory role is becoming progressively evident in both normal and transformed cells. Results: Herein, we present a bioinformatic analysis to generate a comprehensive inosinome picture in lon

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Deshpande, Krutika, Tammy Doan, Kathleen Tsung, et al. "ANGI-13. LONG NON-CODING RNALINC03045 REGULATES GLIOBLASTOMA INVASION VIAWASF3." Neuro-Oncology 26, Supplement_8 (2024): viii18. http://dx.doi.org/10.1093/neuonc/noae165.0072.

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Abstract Glioblastoma (GBM) is an aggressive, heterogeneous tumor characterized by extensive infiltration of tumor cells within the surrounding brain parenchyma. Invasive tumor cells that evade surgical resection, chemoradiation and immune responses underlie GBM recurrence, necessitating the evaluation of factors that govern them. A recently completed unbiased lncRNA CRISPRi screen done by our lab identified LINC03045 as the top potential regulator of GBM invasion in Matrigel assays. Since enhanced LINC03045 expression was also found to be significantly associated with glioma tumor grade and p

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Wang, Ying, and Bin Liu. "Circular RNA in Diseased Heart." Cells 9, no. 5 (2020): 1240. http://dx.doi.org/10.3390/cells9051240.

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Heart disease remains the leading cause of death globally and leads to tremendous socio-economic burden. Despite advances in the field of cardiovascular research, novel theranostics are still in urgent need. Remarkable progress has been made in understanding aberrant protein interactions and signaling pathways in the diseased heart, but less is known regarding epigenetic regulation. Non-coding RNAs have emerged as important regulators of cardiac function and have been implicated in disease. While significant progress has been made in understanding the roles of microRNAs and long non-coding RNA

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Hitachi, Keisuke, Masashi Nakatani, Yuri Kiyofuji, Hidehito Inagaki, Hiroki Kurahashi, and Kunihiro Tsuchida. "An Analysis of Differentially Expressed Coding and Long Non-Coding RNAs in Multiple Models of Skeletal Muscle Atrophy." International Journal of Molecular Sciences 22, no. 5 (2021): 2558. http://dx.doi.org/10.3390/ijms22052558.

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The loss of skeletal muscle mass (muscle atrophy or wasting) caused by aging, diseases, and injury decreases quality of life, survival rates, and healthy life expectancy in humans. Although long non-coding RNAs (lncRNAs) have been implicated in skeletal muscle formation and differentiation, their precise roles in muscle atrophy remain unclear. In this study, we used RNA-sequencing (RNA-Seq) to examine changes in the expression of lncRNAs in four muscle atrophy conditions (denervation, casting, fasting, and cancer cachexia) in mice. We successfully identified 33 annotated lncRNAs and 18 novel l

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Dueñas, Angel, Almudena Expósito, Amelia Aranega, and Diego Franco. "The Role of Non-Coding RNA in Congenital Heart Diseases." Journal of Cardiovascular Development and Disease 6, no. 2 (2019): 15. http://dx.doi.org/10.3390/jcdd6020015.

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Cardiovascular development is a complex developmental process starting with the formation of an early straight heart tube, followed by a rightward looping and the configuration of atrial and ventricular chambers. The subsequent step allows the separation of these cardiac chambers leading to the formation of a four-chambered organ. Impairment in any of these developmental processes invariably leads to cardiac defects. Importantly, our understanding of the developmental defects causing cardiac congenital heart diseases has largely increased over the last decades. The advent of the molecular era

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Lin, Rui, Cheng Liu, and Thomas S. Edgington. "Discovery and Characterization of a Novel Large Non-Coding RNA Transcript, the Mouse Alpha Gene." Blood 104, no. 11 (2004): 4279. http://dx.doi.org/10.1182/blood.v104.11.4279.4279.

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Abstract Recently, a new class of RNAs has been identified that, like mRNAs, are usually transcribed by RNA polymerase II, but lack significant translated open reading frames. They are non-coding RNAs (ncRNAs) that exert roles directly as RNAs, and function as genetic regulators, or riboregulators. In the present study, we discovered a novel very large ncRNA. From differential gene profiling of CD31 positive tumor microvascular endothelial cells from a murine colon carcinoma, we amplified an ~380 bp nucleotide sequence, DP100. This RNA was present in tumor cells as well as tumor vascular endot

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Aliperti, Vincenza, Justyna Skonieczna, and Andrea Cerase. "Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders." Non-Coding RNA 7, no. 2 (2021): 36. http://dx.doi.org/10.3390/ncrna7020036.

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Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, neurodevelopmental and mental disorders. The identification and characterization of lncRNAs that are deregulated or mutated in neurodevelopmental and mental health diseases are fundamental to understanding the complex transcriptional processes in brain function. Crucially, lncRNAs can be explo

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Ran, Na, Sian Liu, Haoran Qi, et al. "Long Non-Coding RNA lncWOX11a Suppresses Adventitious Root Formation of Poplar by Regulating the Expression of PeWOX11a." International Journal of Molecular Sciences 24, no. 6 (2023): 5766. http://dx.doi.org/10.3390/ijms24065766.

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Long non-coding RNAs (lncRNAs), a class of poorly conserved transcripts without protein-encoding ability, are widely involved in plant organogenesis and stress responses by mediating the transmission and expression of genetic information at the transcriptional, posttranscriptional, and epigenetic levels. Here, we cloned and characterized a novel lncRNA molecule through sequence alignment, Sanger sequencing, transient expression in protoplasts, and genetic transformation in poplar. lncWOX11a is a 215 bp transcript located on poplar chromosome 13, ~50 kbp upstream of PeWOX11a on the reverse stra

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Pichler, Martin, Cristian Rodriguez-Aguayo, Su Youn Nam, et al. "Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer." Gut 69, no. 10 (2020): 1818–31. http://dx.doi.org/10.1136/gutjnl-2019-318903.

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ObjectiveTo investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with a pyknon motif), and to characterise its potential as a biomarker and therapeutic target.DesignFLANC expression was analysed in 349 tumours from four cohorts and correlated to clinical data. In a series of multiple in vitro and in vivo models and molecular analyses, we characterised the fundamental biological roles of this lncRNA. We further explored the therapeutic potential of targeting FLANC in a mouse model of colorectal cancer (CRC) m

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Yang, Mengli, Rui Wang, Haijian Sun, Ming Dong та Qiang Chen. "Abstract 3067: The long non-coding RNA CDH3-AS1 facilitates gemcitabine resistance and lung metastasis via TGFβ activation in pancreatic ductal adenocarcinoma". Cancer Research 85, № 8_Supplement_1 (2025): 3067. https://doi.org/10.1158/1538-7445.am2025-3067.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with chemotherapy serving as the primary treatment for PDAC when surgery is not feasible. Gemcitabine is commonly used as the first-line chemotherapeutic agent in PDAC treatment, yet resistance to gemcitabine frequently emerges, necessitating the development of novel strategies to improve its efficacy. In our study, we established a gemcitabine resistant PDAC cell model through an evolutionary process involving gradually increasing gemcitabine concentrations. RNA-Seq analysis revealed significant upregulat

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Nadir, Khan1 Farzeen Shaba2 Abu Sehma3 Mohd Faizan4 Rumana Siddqui5 Dr. Mohd Abid6*. "A Comprehensive Review About Exploring the Functional Diversity, Structural Complexity, And Interconnectivity of RNA Molecules: Implications for Gene Regulation, Cellular Processes, And Therapeutic Innovations." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2171–80. https://doi.org/10.5281/zenodo.15398199.

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RNA (ribonucleic acid) is a versatile biomolecule that plays fundamental roles in gene expression, protein synthesis, and cellular regulation. Beyond its well-known functions in transcription and translation, RNA participates in various regulatory and structural processes essential for maintaining cellular homeostasis. This review explores the diversity of RNA molecules, including messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), and non-coding RNAs such as small nuclear RNA (snRNA), microRNA (miRNA), small interfering RNA (siRNA), long non-coding RNA (lncRNA), circular RNA (cir

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Garratt, Hester, Robert Ashburn, Miron Sopić, Antonella Nogara, Andrea Caporali, and Tijana Mitić. "Long Non-Coding RNA Regulation of Epigenetics in Vascular Cells." Non-Coding RNA 7, no. 4 (2021): 62. http://dx.doi.org/10.3390/ncrna7040062.

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The vascular endothelium comprises the interface between the circulation and the vessel wall and, as such, is under the dynamic regulation of vascular signalling, nutrients, and hypoxia. Understanding the molecular drivers behind endothelial cell (EC) and vascular smooth muscle cell (VSMC) function and dysfunction remains a pivotal task for further clinical progress in tackling vascular disease. A newly emerging era in vascular biology with landmark deep sequencing approaches has provided us with the means to profile diverse layers of transcriptional regulation at a single cell, chromatin, and

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Xu, Wen, Bei Wang, Yuxuan Cai, et al. "ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis." Current Pharmaceutical Design 27, no. 23 (2021): 2722–27. http://dx.doi.org/10.2174/1381612827666210325105106.

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Background: Long non-coding RNAs (lncRNA) have been identified as novel molecular regulators in cancers. LncRNA ADAMTS9-AS2 can mediate the occurrence and development of cancer through various ways, such as regulating miRNAs, activating the classical signaling pathways in cancer, and so on, which have been studied by many scholars. In this review, we summarize the molecular mechanisms of ADAMTS9-AS2 in different human cancers. Methods: Through a systematic search of PubMed, lncRNA ADAMTS9-AS2 mediated molecular mechanisms in cancer are summarized inductively. Results: ADAMTS9-AS2 aberrantly ex

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Szymanowska, Anna, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, and Paola Amero. "Non-Coding RNAs: Foes or Friends for Targeting Tumor Microenvironment." Non-Coding RNA 9, no. 5 (2023): 52. http://dx.doi.org/10.3390/ncrna9050052.

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Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and growth regulation. They are key regulators of important cellular pathways in the tumor microenvironment. To analyze ncRNAs in the tumor microenvironment, the use of RNA sequencing technology has revolutionized the field. The advancement of this technique has broadened our understanding of the molecular biology of cancer, presenting abundant possibilities for the exploration of novel biomarkers for cancer treatment. In this review, we will summarize recent achievements in understanding the complex role of ncRNA

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Ding-Gan, Liu. "Independent 3'untranslated region RNA, a novel non-coding regulator RNA: what do we know now?" Biohelikon 2, no. 1 (2014). https://doi.org/10.5281/zenodo.888123.

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An independent 3’untranslated region RNA (I3’UTR) is a non-coding RNA, which consists only of the 3’untranslated region of an mRNA, and exists in cells independently, detached from its original mRNA. As presently known, I3’UTRs are expressed from the promoters in the 3’untranslated region of protein-coding genes. In the past twenty years, studies on this type of RNA were only sporadically published, but it was noticed that tumor suppression was a common function of all the I3’UTRs in these studies. Recently, evidence has been presented that the I3’UTRs generally exist in eukaryotes, and are a

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Jin, Fangfang, and Zhigang Guo. "Emerging role of a novel small non-coding regulatory RNA: tRNA-derived small RNA." ExRNA 1, no. 1 (2019). http://dx.doi.org/10.1186/s41544-019-0036-7.

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Abstract The discovery of small non-coding RNAs, such as miRNA and piRNA, has dramatically changed our understanding of the role RNA plays in organisms. Recent studies show that a novel small non-coding RNA generated from cleavage of tRNA or pre-tRNA, called tRNA-derived small RNA (tsRNA), serves as a new regulator of gene expression. tsRNA has been determined participate in regulating some specific physiological and pathological processes. Although knowledge regarding the biological roles of miRNA and piRNA is expanding, whether tsRNAs play similar roles remains poorly understood. Here, we re

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Li, Yuhuang, Hong Jin, Albert Busch, et al. "Abstract 311: The Long Non-Coding RNA H19 Regulates Experimental Abdominal Aortic Aneurysm Development and Progression." Arteriosclerosis, Thrombosis, and Vascular Biology 37, suppl_1 (2017). http://dx.doi.org/10.1161/atvb.37.suppl_1.311.

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Background: Long noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators in various biological processes and diseases. Here we sought to identify and functionally characterize the lncRNA H19 as a novel regulator in abdominal aortic aneurysm development. Methods and Results: We profiled RNA transcript expression in two murine abdominal aortic aneurysm models, Angiotensin II (ANGII) infusion in ApoE-/- mice and porcine pancreatic elastase (PPE) instillation in C57BL/6 wildtype mice. The lncRNA H19 was identified as one of the most highly up-regulated transcripts in both mouse ane

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Luo, Changjun, Si Xiong, Yiteng Huang, et al. "The Novel Non-coding Transcriptional Regulator Gm18840 Drives Cardiomyocyte Apoptosis in Myocardial Infarction Post Ischemia/Reperfusion." Frontiers in Cell and Developmental Biology 9 (July 12, 2021). http://dx.doi.org/10.3389/fcell.2021.615950.

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BackgroundIschemia/reperfusion-mediated myocardial infarction (MIRI) is a major pathological factor implicated in the progression of ischemic heart disease, but the key factors dysregulated during MIRI have not been fully elucidated, especially those essential non-coding factors required for cardiovascular development.MethodsA murine MIRI model and RNA sequencing (RNA-seq) were used to identify key lncRNAs after myocardial infarction. qRT-PCR was used to validate expression in cardiac muscle tissues and myocardial cells. The role of Gm18840 in HL-1 cell growth was determined by flow cytometry

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Coego, Alba, Helena Covelo-Molares, and Diana Guallar. "Epitranscriptomics: new players in an old game." Biochemical Society Transactions, April 4, 2023. http://dx.doi.org/10.1042/bst20221417.

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Ageing is a conserved and unavoidable biological process characterized by progressive decline of physiological functions with time. Despite constituting the greatest risk factor for most human diseases, little is known about the molecular mechanisms driving the ageing process. More than 170 chemical RNA modifications, also known as the epitranscriptome, decorate eukaryotic coding and non-coding RNAs and have emerged as novel regulators of RNA metabolism, modulating RNA stability, translation, splicing or non-coding RNA processing. Studies on short-lived organisms such as yeast or worms connect

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