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Journal articles on the topic 'NP (Nanoparticle)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Das, Ankita, and Pranab Dutta. "Antifungal Activity of Biogenically Synthesized Silver and Gold Nanoparticles Against Sheath Blight of Rice." Journal of Nanoscience and Nanotechnology 21, no. 6 (2021): 3547–55. http://dx.doi.org/10.1166/jnn.2021.18996.

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Biogenically synthesized silver and gold nanoparticles were evaluated for antifungal activity against Rhizoctonia solani causing sheath blight of rice. Both the nanoparticles were tested at 1, 5, 10, 50, 100 and 200 ppm along with chemical check against the pathogen. Silver nanoparticle (Ag NP) at 200 ppm showed the highest inhibition (73.39%) in the radial growth of R. solani, while gold nanoparticle (Au NP) at the same concentration inhibited the growth of the pathogen up to 60.83%. Study on mode of action of nanoparticle by electron microscopy showed that Ag NP accumulate inside the fungal

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Lee, Jae Hoon, Shin Young Park, In-Gyu Choi, and Joon Weon Choi. "Investigation of Molecular Size Effect on the Formation of Lignin Nanoparticles by Nanoprecipitation." Applied Sciences 10, no. 14 (2020): 4910. http://dx.doi.org/10.3390/app10144910.

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In recent years, several studies focused on the synthesis of lignin-based nanoparticle in aqueous solution and its potential applications of the drug carrier were investigated. In this study, soda lignin (SL) nanoparticles (i.d. 128–560 nm) were synthesized by the nanoprecipitation process at three different concentrations (1, 2, and 4 mg/mL THF) with various molecular sizes of soda lignin (NP-F1, NP-F2, and NP-F3) obtained from sequential solvent extraction. The average molecular weights of SL, F1, F2, F3, F4, and F5 were 3130, 1190, 2550, 3680, 5310, and 14,650, respectively. The average siz

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Abdulle, Aniza, and James C. L. Chow. "Contrast Enhancement for Portal Imaging in Nanoparticle-Enhanced Radiotherapy: A Monte Carlo Phantom Evaluation Using Flattening-Filter-Free Photon Beams." Nanomaterials 9, no. 7 (2019): 920. http://dx.doi.org/10.3390/nano9070920.

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Our team evaluated contrast enhancement for portal imaging using Monte Carlo simulation in nanoparticle-enhanced radiotherapy. Dependencies of percentage contrast enhancement on flattening-filter (FF) and flattening-filter-free (FFF) photon beams were determined by varying the nanoparticle material (gold, platinum, iodine, silver, iron oxide), nanoparticle concentration (3–40 mg/mL) and photon beam energy (6 and 10 MV). Phase-space files and energy spectra of the 6 MV FF, 6 MV FFF, 10 MV FF and 10 MV FFF photon beams were generated based on a Varian TrueBeam linear accelerator. We found that g

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Mishra, Dr Manoj, and Dr Preeti Chahal. "Nanoparticle-Mediated Drug Delivery to Cervical Cells: Harnessing the Potential of Liposomes for Enhanced Therapeutic Efficacy." Migration Letters 20, S13 (2023): 255–64. http://dx.doi.org/10.59670/ml.v20is13.6291.

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Cervical cancer continues to pose a substantial worldwide health obstacle, requiring novel treatment approaches. This research investigates the capacity of Nanoparticle-Mediated Drug Delivery to augment the efficacy of cervical cancer therapy. Highlighting the significance of precise medication delivery, using nanoparticles, namely liposomes, appears viable. Introducing a new method called Nanoparticle-Based Drug Delivery to Cervical Cells (NP-DD-CC) utilizes liposomes to accurately deliver medicinal substances while minimizing adverse effects on the whole body. The NP-DD-CC has remarkable cha

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Cleare, Levi G., Kevin L. Li, Waleed M. Abuzeid, Parimala Nacharaju, Joel M. Friedman, and Joshua D. Nosanchuk. "NO Candida auris: Nitric Oxide in Nanotherapeutics to Combat Emerging Fungal Pathogen Candida auris." Journal of Fungi 6, no. 2 (2020): 85. http://dx.doi.org/10.3390/jof6020085.

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Candida auris (C. auris) is an emerging pathogenic fungal species that is especially worrisome due to its high mortality rates and widespread antifungal resistance. Previous studies have demonstrated the efficacy of nitric oxide (NO) nanoparticles on Candida species, and, to our knowledge, this is the first study to investigate the antifungal effects of a NO-generating nanoparticle on C. auris. Six C. auris strains were incubated with a nanoparticle (NAC-SNO-np), which releases N-acetylcysteine S-nitrosothiol (NAC-SNO) and N-acetylcysteine (NAC), and generates NO, through colony forming unit (

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Meidina, Adinda Nezma, Akbar Triandra, Nabila Az-zahra Hasibuan, and M. Alif Al Fajri. "Potensi Teknologi Nanopartikel Logam Seng Oksida (NP-ZnO) pada Obat Anti-TB Sebagai Modalitas Mutakhir Pengobatan Penyakit Multidrug-Resistant Tuberculosis (MDR-TB)." SCRIPTA SCORE Scientific Medical Journal 5, no. 2 (2024): 156–64. http://dx.doi.org/10.32734/scripta.v5i2.15230.

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Background: Tuberculosis (TB) is a treatable infectious disease caused by the Mycobacterium tuberculosis pathogen. However, patient non-compliance during treatment contributes to the emergence of Multidrug-resistant Tuberculosis (MDR-TB). This literature review aims to further explore the potential of zinc oxide metal nanoparticles (NP-ZnO) in anti-TB drugs as an advanced modality for MDR-TB treatment by enhancing drug efficacy, reducing intestine degradation, and increasing absorption and bioavailability. Methods: Literature was searched using search engines such as Google Scholar, Science Di

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Baalousha, Mohammed, Mithun Sikder, Ashwini Prasad, Jamie Lead, Ruth Merrifield, and G. Thomas Chandler. "The concentration-dependent behaviour of nanoparticles." Environmental Chemistry 13, no. 1 (2016): 1. http://dx.doi.org/10.1071/en15142.

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Environmental context Studies of manufactured nanoparticles (NPs) in the environment have been performed almost exclusively at high NP concentrations. These data lead to misunderstandings related to NP fate and effects at relevant environmental concentrations, which are expected to be low. A better understanding of the concentration-dependent behaviour of NPs will improve our understanding of their fate and effects under environmentally realistic conditions. Abstract This rapid communication highlights the importance of nanoparticle concentration in determining their environmental fate and beh

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Zhang, Ren, Bongjoon Lee, Michael R. Bockstaller, et al. "Soft-shear induced phase-separated nanoparticle string-structures in polymer thin films." Faraday Discussions 186 (2016): 31–43. http://dx.doi.org/10.1039/c5fd00141b.

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Application of shear stress has been shown to unidirectionally orient the microstructures of block copolymers and polymer blends. In the present work, we study the phase separation of a novel nanoparticle (NP)–polymer blend thin film system under shear using a soft-shear dynamic zone annealing (DZA-SS) method. The nanoparticles are densely grafted with polymer chains of chemically dissimilar composition from the matrix polymer, which induces phase separation upon thermal annealing into concentrated nanoparticle domains. We systematically examine the influence of DZA-SS translation speed and th

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Ani, Hussam Nadum Abdalraheem Al, Anca Maria Cimbru, Corneliu Trisca-Rusu, Szidonia Katalin Tanczos, Adriana Cuciureanu, and Aurelia Cristina Nechifor. "Iono-molecular Separation with Composite Membranes II. Preparation and characterization of polysulphone and composite nanoparticles." Revista de Chimie 68, no. 2 (2017): 203–9. http://dx.doi.org/10.37358/rc.17.2.5420.

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This paper illustrates the possibility of producing iono-molecular separations using ionic colloidal ultrafiltration membrane of polysulfone synthetic solutions of cupric ions and nitro phenols through ultrafiltration assisted by polymeric nanoparticle composites based on polysulfone. In the present work, in order to reduce the operating pressure and increase the flow of water we are using the process of ultrafiltration through a polysulfone membrane in N-methylpyrrolidone 10% prepared by coagulation in isopropanol. The nanoparticles needed in colloidal ultrafiltration had been obtained throug

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Soto, Ernesto R., Abaigeal C. Caras, Lindsey C. Kut, Melissa K. Castle, and Gary R. Ostroff. "Glucan Particles for Macrophage Targeted Delivery of Nanoparticles." Journal of Drug Delivery 2012 (October 13, 2012): 1–13. http://dx.doi.org/10.1155/2012/143524.

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Glucan particles (GPs) are hollow, porous 2–4 μm microspheres derived from the cell walls of Baker's yeast (Saccharomyces cerevisiae). The 1,3-β-glucan outer shell provides for receptor-mediated uptake by phagocytic cells expressing β-glucan receptors. GPs have been used for macrophage-targeted delivery of soluble payloads (DNA, siRNA, protein, and small molecules) encapsulated inside the hollow GPs via core polyplex and layer-by-layer (LbL) synthetic strategies. In this communication, we report the incorporation of nanoparticles as cores inside GPs (GP-NP) or electrostatically bound to the su

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Malamatari, Maria, Anastasia Charisi, Stavros Malamataris, Kyriakos Kachrimanis, and Ioannis Nikolakakis. "Spray Drying for the Preparation of Nanoparticle-Based Drug Formulations as Dry Powders for Inhalation." Processes 8, no. 7 (2020): 788. http://dx.doi.org/10.3390/pr8070788.

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Nanoparticle-based therapeutics have been used in pulmonary formulations to enhance delivery of poorly water-soluble drugs, protect drugs against degradation and achieve modified release and drug targeting. This review focuses on the use of spray drying as a solidification technique to produce microparticles containing nanoparticles (i.e., nanoparticle (NP) agglomerates) with suitable properties as dry powders for inhalation. The review covers the general aspects of pulmonary drug delivery with emphasis on nanoparticle-based dry powders for inhalation and the principles of spray drying as a me

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An, Lu, Di Zhang, Lin Zhang, and Gang Feng. "Effect of nanoparticle size on the mechanical properties of nanoparticle assemblies." Nanoscale 11, no. 19 (2019): 9563–73. http://dx.doi.org/10.1039/c9nr01082c.

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Guo, Huanhuan, Yong Liu, Jidai Chen, Yan Zhu, and Zihan Zhang. "The Effects of Several Metal Nanoparticles on Seed Germination and Seedling Growth: A Meta-Analysis." Coatings 12, no. 2 (2022): 183. http://dx.doi.org/10.3390/coatings12020183.

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Using the proper means to improve seed germination is of great significance in agriculture and forestry. Here, a meta-analysis was used to examine whether metal nanoparticle treatments have a specific effect on the seed germination and seedling growth of agricultural species. Using the Web of Science (1950–2021), PubMed (1950–2021), and Scopus (1950–2021) databases, a paper search was conducted using the following items (“nanoparticles” and “seed germination”, “nanomaterials” and “seed germination”) to filter the references in the title, abstract, and keywords of the published articles. The re

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14

Jan, Jeng Shiung, Po Jui Chen, and Yu Han Ho. "Synthesis of Gold Nanoparticle/Silica Nanostructures." Materials Science Forum 688 (June 2011): 321–25. http://dx.doi.org/10.4028/www.scientific.net/msf.688.321.

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A novel approach is proposed to prepare organic-inorganic composite tubular structure by mineralizing silica and/or gold nanoparticle in the LbL assembled polypeptide multilayers films. Mesoporous silica (m-SiO2) and gold nanoparticle/mesoporous silica (Au NP/m-SiO2) tubes were prepared by subsequent calcination. The LbL assembled poly-L-lysine (PLL)/poly-L-tyrosine (PLT) multilayer film within the inner pores of polycarbonate templates acts as both a mineralizing agent and template for the formation of these materials. The as-prepared mesoporous SiO2and Au NP/m-SiO2tubes have well-defined str

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Robinson, D. A., J. Duay, A. M. Kondajji, and K. J. Stevenson. "Mechanistic aspects of hydrazine-induced Pt colloid instability and monitoring aggregation kinetics with nanoparticle impact electroanalysis." Faraday Discussions 193 (2016): 293–312. http://dx.doi.org/10.1039/c6fd00121a.

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Here we investigate the mechanistic aspects of Pt nanoparticle (NP) aggregation in solutions typically used for detecting NP/electrode impacts by electrocatalytic amplification (ECA). We previously proposed a general mechanism for Pt colloid destabilization that involved the participation of both the hydrazine redox probe and the pH buffer species as coagulants. Herein the Pt NP coagulation and aggregation mechanisms were further investigated with microscopic kinetic NP concentration monitoring and zeta potential measurements using nanoparticle tracking analysis (NTA), as well as open circuit

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Sikder, Mithun, Jingjing Wang, Brett A. Poulin, Malak M. Tfaily, and Mohammed Baalousha. "Nanoparticle size and natural organic matter composition determine aggregation behavior of polyvinylpyrrolidone coated platinum nanoparticles." Environmental Science: Nano 7, no. 11 (2020): 3318–32. http://dx.doi.org/10.1039/d0en00659a.

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Kumar, Akash, and Raja Gopal Rayavarapu. "Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol." Beilstein Journal of Nanotechnology 15 (November 4, 2024): 1312–32. http://dx.doi.org/10.3762/bjnano.15.106.

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Heavy metal ions and organic pollutants, such as 4-nitrophenol (4-NP), pose significant environmental and human health threats. Addressing these challenges necessitates using advanced nanoparticle-based systems capable of efficient detection and degradation. However, conventional approaches utilizing strong capping agents like cetrimonium bromide (CTAB) on nanoparticles lead to limitations due to the rigid nature of CTAB. This restricts its utility in heavy metal detection and 4-NP degradation, requiring additional surface modifications using linker molecules, thereby increasing process comple

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Xu, Wu, and Xiaohu Liu. "Computational study on the uptake of soft nanoparticles and nanoparticle cluster by cells." Journal of Applied Physics 132, no. 17 (2022): 174702. http://dx.doi.org/10.1063/5.0111797.

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Nanoparticles (NPs) and exosomes used to transport therapeutic drug molecules to cells have attracted considerable attention in biopharmaceuticals. However, soft NPs entering cells with different angles are hard to be simulated by traditional theoretical endocytic models, let alone clustering of NPs with varied shapes. Here, the endocytic model based on the co-rotational grid method is implemented. The endocytosis of a single soft NP and a nanoparticle cluster (NPC) are investigated. Both the actin force and the dynamic assembly of the clathrin coat have been considered. The results show that

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Lai, Xialian, Fengjiao Yao, Yacong An, Xundou Li, and Xian-Da Yang. "Novel Nanotherapeutics for Cancer Immunotherapy by PD-L1-Aptamer-Functionalized and Fexofenadine-Loaded Albumin Nanoparticles." Molecules 28, no. 6 (2023): 2556. http://dx.doi.org/10.3390/molecules28062556.

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Immune checkpoint blockade (ICB) is an important strategy for cancer treatment and has achieved remarkable clinical results. Further enhancement of the efficacy of ICB therapy with a new technical approach is of potential medical importance. In this study, we constructed a novel nanotherapeutic agent (PDL1-NP-FEXO) for cancer immunotherapy by attaching PD-L1 aptamers to albumin nanoparticles that were loaded with H1-antihitamine fexofenadine (FEXO). FEXO has been reported to enhance the immunotherapy response by reducing the immunosuppressive M2-like macrophages in the tumor microenvironment.

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Montes, Sarah, Agustín Etxeberria, Javier Rodriguez, and Jose A. Pomposo. "Homogenization of Mutually Immiscible Polymers Using Nanoscale Effects: A Theoretical Study." Research Letters in Physical Chemistry 2008 (June 9, 2008): 1–4. http://dx.doi.org/10.1155/2008/504917.

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A theoretical study to investigate homogenization of mutually immiscible polymers using nanoscale effects has been performed. Specifically, the miscibility behavior of all-polymer nanocomposites composed of linear-polystyrene (PS) chains and individual cross-linked poly(methyl methacrylate)-nanoparticles (PMMA-NPs) has been predicted. By using a mean field theory accounting for combinatorial interaction energy and nanoparticle-driven effects, phase diagrams were constructed as a function of PMMA-NP size, PS molecular weight, and temperature. Interestingly, complete miscibility (i.e., homogenei

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Nestele, Jeremy A., Anne-Katrin Rohlfing, Valerie Dicenta, et al. "Characterization of GPVI- or GPVI-CD39-Coated Nanoparticles and Their Impact on In Vitro Thrombus Formation." International Journal of Molecular Sciences 23, no. 1 (2021): 11. http://dx.doi.org/10.3390/ijms23010011.

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Traditional antithrombotic agents commonly share a therapy-limiting side effect, as they increase the overall systemic bleeding risk. A novel approach for targeted antithrombotic therapy is nanoparticles. In other therapeutic fields, nanoparticles have enabled site-specific delivery with low levels of toxicity and side effects. Here, we paired nanotechnology with an established dimeric glycoprotein VI-Fc (GPVI-Fc) and a GPVI-CD39 fusion protein, thereby combining site-specific delivery and new antithrombotic drugs. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles, NP-BSA, NP-GPVI and NP-GPVI

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Baimler, I. V., A. V. Simakin, and S. V. Gudkov. "Investigation of the laser-induced breakdown plasma, acoustic vibrations and dissociation processes of water molecules caused by laser breakdown of colloidal solutions containing Ni nanoparticles." Plasma Sources Science and Technology 30, no. 12 (2021): 125015. http://dx.doi.org/10.1088/1361-6595/ac39ae.

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Abstract In this work the process of optical breakdown under laser irradiation by nanosecond pulses with an energy of 650 mJ of aqueous solutions of Ni nanoparticles is investigated. A monotonic change in the number of breakdowns, the average distance between closest breakdowns, the average plasma size of an individual breakdown, the luminosity of a plasma flash, the intensity of acoustic signals, and the rate of formation of dissociation products—O2, H2, OH•, and H2O2 with an increase in the irradiation time was established. With an increase in the concentration of nanoparticles, the measured

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Pallavicini, Piersandro, Luca Preti, Maria L. Protopapa, et al. "Nanoparticle-Imprinted Silica Gel for the Size-Selective Capture of Silver Ultrafine Nanoparticles from Water." Molecules 28, no. 10 (2023): 4026. http://dx.doi.org/10.3390/molecules28104026.

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A synthetic approach has been developed to prepare silica gel monoliths that embed well separated silver or gold spherical nanoparticles (NP), with diameters of 8, 18 and 115 nm. Fe3+, O2/cysteine and HNO3 were all successfully used to oxidize and remove silver NP from silica, while aqua regia was necessary for gold NP. In all cases, NP-imprinted silica gel materials were obtained, with spherical voids of the same dimensions of the dissolved particles. By grinding the monoliths, we prepared NP-imprinted silica powders that were able to efficiently reuptake silver ultrafine NP (Ag-ufNP, d = 8 n

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Sadat, Md Ehsan, Sergey L. Bud’ko, Rodney C. Ewing, et al. "Effect of Dipole Interactions on Blocking Temperature and Relaxation Dynamics of Superparamagnetic Iron-Oxide (Fe3O4) Nanoparticle Systems." Materials 16, no. 2 (2023): 496. http://dx.doi.org/10.3390/ma16020496.

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The effects of dipole interactions on magnetic nanoparticle magnetization and relaxation dynamics were investigated using five nanoparticle (NP) systems with different surfactants, carrier liquids, size distributions, inter-particle spacing, and NP confinement. Dipole interactions were found to play a crucial role in modifying the blocking temperature behavior of the superparamagnetic nanoparticles, where stronger interactions were found to increase the blocking temperatures. Consequently, the blocking temperature of a densely packed nanoparticle system with stronger dipolar interactions was f

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Al-Husseini, Jacob, Meenakshi Upreti, Joseph Ha, et al. "EXTH-71. A MECHANISTIC INVESTIGATION INTO AUGER THERAPY: 2-DIMENSIONAL THIN-FILMS TO CHARACTERIZE THERAPEUTIC RANGEIN VITRO." Neuro-Oncology 26, Supplement_8 (2024): viii253. http://dx.doi.org/10.1093/neuonc/noae165.1001.

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Abstract Metallic nanoparticles can improve the accuracy and effectiveness of conventional radiotherapy in the treatment of solid tumors through a light-matter interaction known as the Auger effect. In this work, we present the assembly of an iron oxide (Fe3O4) nanoparticle (NPs) layer within a biocompatible polyelectrolyte film using ionic self-assembly to enable the spatial separation of NPs from their target cells. Films exhibited uniform nanoparticle coverage as well as strong stability in cell culture conditions. To investigate the applicability of NMDR with non-internalized NPs, conditio

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Pande, Megha, Shrikant Tyagi, Suresh Kumar, et al. "Effects of Unconjugated Gold, Silver and Titanium Dioxide Nanoparticles on Bovine Spermatozoa at Various Stages of Cryopreservation." Cryoletters 43, no. 3 (2022): 150–57. http://dx.doi.org/10.54680/fr22310110512.

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BACKGROUND: The increasing use of nanoparticles (NP) for gender-selected spermatozoa, spermenriched semen and novel extenders raises the concern of undesirable effects on fertility and sperm function. OBJECTIVE: To investigate the effects of gold (Au-), silver (Ag-), and titanium dioxide (TiO2 -) NPs on the motility and sperm functions in bovine spermatozoa at various stages of cryopreservation. MATERIALS AND METHODS: Frieswal (Sahiwal × Holstein Friesian) bull semen ejaculates (N = 24) were challenged with unconjugated and ligand-free Au-, Ag-, and TiO2 -NPs. RESULTS: At post-dilution (fresh)

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Lai, Shutong, Eric Aubry, Olivier Sublemontier, and Pascal Briois. "One-Step Synthesis of TiO2/SiO2-np Nanocomposite Photocatalytic Multilayer Films: Effect of Incorporation Time Sequences of SiO2 Nanoparticles during the TiO2 Film Growth." Materials 17, no. 6 (2024): 1227. http://dx.doi.org/10.3390/ma17061227.

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In this article, the TiO2/SiO2-np nanocomposite multilayer films were synthesized in a single step by reactive magnetron sputtering combined with a nanoparticle aerosol jet. The SiO2 nanoparticles (SiO2-np) were introduced into a growing TiO2 thin film with different time sequences during deposition for a fixed duration. The SiO2-np acting as impurities are introduced into the TiO2 to willingly disturb its growth and to cause growth defects in order to increase the specific surface area of the photocatalytic film. In reason of the non-photoactive properties of the SiO2 nanoparticles, their int

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Liu, Yujie, Yiliang Yang, and Xianrong Qi. "Combination Therapy for Overcoming Multidrug Resistance in Breast Cancer Through Hedgehog Signaling Pathway Regulation." Pharmaceutics 17, no. 5 (2025): 572. https://doi.org/10.3390/pharmaceutics17050572.

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Background/Objectives: The ineffective delivery of drugs into tumors and the existence of multidrug resistance (MDR) are the primary causes of chemotherapy failure. Downregulation of the Sonic Hedgehog (Shh) pathway has been shown to reduce P-glycoprotein (P-gp) expression on cell membranes and to resist MDR. Methods: In this study, we combine cyclopamine (CYP, a potent Shh antagonist) with paclitaxel (PTX, an antitumor drug that can produce MDR) in a nano-drug delivery system (CYP NP and PTX NP) for the treatment of drug-resistant breast cancer. Nanoparticles were characterized for size, zeta

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Wu, Hong, Jun Wang, Zhemin Wang, Darrell R. Fisher, and Yuehe Lin. "Apoferritin-Templated Yttrium Phosphate Nanoparticle Conjugates for Radioimmunotherapy of Cancers." Journal of Nanoscience and Nanotechnology 8, no. 5 (2008): 2316–22. http://dx.doi.org/10.1166/jnn.2008.177.

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We report a templated-synthetic approach based on protein-cage of apoferritin to prepare radionuclide nanoparticle (NP) conjugates. Non-radioactive yttrium (89Y) was used as a model target and surrogate for radioyttrium (90Y) to prepare the nanoparticle conjugate. The center cavity and multiple channel structure of apoferritin offer a fast and facile method to precipitate yttrium phosphate by diffusing yttrium and phosphate ions into the cavity of apoferritin, resulting a core–shell nanoparticle. The yttrium phosphate/apoferritin nanoparticle was functionalized with biotin for further applicat

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Singhal, Ankush, and G. J. Agur Sevink. "A Core-Shell Approach for Systematically Coarsening Nanoparticle–Membrane Interactions: Application to Silver Nanoparticles." Nanomaterials 12, no. 21 (2022): 3859. http://dx.doi.org/10.3390/nano12213859.

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The continuous release of engineered nanomaterial (ENM) into the environment may bring about health concerns following human exposure. One important source of ENMs are silver nanoparticles (NPs) that are extensively used as anti-bacterial additives. The introduction of ENMs into the human body can occur via ingestion, skin uptake or the respiratory system. Therefore, evaluating how NPs translocate over bio-membranes is essential in assessing their primary toxicity. Unfortunately, data regarding membrane–NP interaction is still scarce, as is theoretical and in silico insight into what governs a

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Sipos, Arnold, Kwang-Jin Kim, Constantinos Sioutas, and Edward D. Crandall. "Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells." International Journal of Molecular Sciences 20, no. 21 (2019): 5253. http://dx.doi.org/10.3390/ijms20215253.

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Background: Polystyrene nanoparticles (PNP) are taken up by primary rat alveolar epithelial cell monolayers (RAECM) in a time-, dose-, and size-dependent manner without involving endocytosis. Internalized PNP in RAECM activate autophagy, are delivered to lysosomes, and undergo [Ca2+]-dependent exocytosis. In this study, we explored nanoparticle (NP) interactions with A549 cells. Methods: After exposure to PNP or ambient pollution particles (PM0.2), live single A549 cells were studied using confocal laser scanning microscopy. PNP uptake and egress were investigated and activation of autophagy w

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Kwon, Seong Jung. "Electrochemical Observation and Analysis of Stochastic Single Nanoparticle Collisions on Ultramicroelectrode Using Pt, Ag, Cu, and Ni Nanoparticle." ECS Meeting Abstracts MA2022-01, no. 45 (2022): 1940. http://dx.doi.org/10.1149/ma2022-01451940mtgabs.

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We describe the electrochemical detection of single nanoparticle (NP) collision at an ultramicroelectrode (UME) with various NPs such as Pt, Ag, Cu, and Ni NP. We could observe the single NP collision through the enhanced current by electrocatalytic redox recycling. The overall current transient caused by the NP collision was differed depending on the NP collision system. The peak height and frequency of the current response are proportional to the size and concentration of the NP. The current response is very sensitive to the material and surface state of the measuring electrode. It also chan

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Kaler, Abhishek, Sanyog Jain, and Uttam Chand Banerjee. "Green and Rapid Synthesis of Anticancerous Silver Nanoparticles bySaccharomyces boulardiiand Insight into Mechanism of Nanoparticle Synthesis." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/872940.

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Rapidly developing field of nanobiotechnology dealing with metallic nanoparticle (MNP) synthesis is primarily lacking control over size, shape, dispersity, yield, and reaction time. Present work describes an ecofriendly method for the synthesis of silver nanoparticles (AgNPs) by cell free extract (CFE) ofSaccharomyces boulardii. Parameters such as culture age (stationary phase growth), cell mass concentration (400 mg/mL), temperature (35°C), and reaction time (4 h), have been optimized to exercise a control over the yield of nanoparticles and their properties. Nanoparticle (NP) formation was c

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Kalaivani, P., and G. Mathubala. "Green synthesis of AgO nanoparticles using Prosopis Cineraria bark extract and its antibacterial activity." Journal of Physics: Conference Series 2886, no. 1 (2024): 012001. http://dx.doi.org/10.1088/1742-6596/2886/1/012001.

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Abstract The green synthesis of AgO nanoparticles (NP) uses plant elements like terpenoids, polyphenols, carbohydrates, enzymes, flavonoids, lipids, and alkaloids as reducing agents. A biodegradable technique produces silver oxide nanoparticles from Prosopis cineraria bark extract. This paper defines a biologically friendly, simple, cost-free, and predictable production of AgO nanoparticles (NP) from Prosopis cineraria aqueous bark extract, as well as their antibacterial efficacy. Silver oxide nanoparticles (NP) were green-produced with a bark extract of Prosopis cineraria, acting as a cap and

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Huang, Huan Di, Hui Juan Zhu, Liang Shu Jiang, and Huan Yu Zhao. "Ag Nanoparticle Functionalized TiO₂ Nanowire Thin Film and its Gas-Sensing Application at Room Temperature." Applied Mechanics and Materials 275-277 (January 2013): 1822–25. http://dx.doi.org/10.4028/www.scientific.net/amm.275-277.1822.

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Ag nanoparticle functionalized TiO2nanowire (TiO2NW @ Ag NP) was synthesized and the gas sensing properties of the nanowire film was investigated. The size and the distribution density of Ag nanoparticles can be easily controlled. The sensor based on Ag nanoparticle functionalized TiO2 nanowire thin film has promising sensing properties, and at room temperature, its sensitivity towards H2and O2can reach 500 ppm and 1000 ppm respectively.

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Naskar, Atanu, Sreenivasulu Kilari, Gaurav Baranwal, Jamie Kane, and Sanjay Misra. "Nanoparticle-Based Drug Delivery for Vascular Applications." Bioengineering 11, no. 12 (2024): 1222. https://doi.org/10.3390/bioengineering11121222.

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Nanoparticle (NP)-based drug delivery systems have received widespread attention due to the excellent physicochemical properties of nanomaterials. Different types of NPs such as lipid NPs, poly(lactic-co-glycolic) acid (PLGA) NPs, inorganic NPs (e.g., iron oxide and Au), carbon NPs (graphene and carbon nanodots), 2D nanomaterials, and biomimetic NPs have found favor as drug delivery vehicles. In this review, we discuss the different types of customized NPs for intravascular drug delivery, nanoparticle behaviors (margination, adhesion, and endothelium uptake) in blood vessels, and nanomaterial

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Manke, Amruta, Liying Wang, and Yon Rojanasakul. "Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity." BioMed Research International 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/942916.

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The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors. The unique physicochemical and electrical properties of engineered nanoparticles (NP) make them highly desirable in a variety of applications. However, these novel properties of NP are fraught with concerns for environmental and occupational exposure. Changes in structural and physicochemical properties of NP can lead to changes in biological activities including ROS generation, one of the most frequently reported NP-associated toxicities. Oxidative stress induced b

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Amruta Mhatugade, Amruta Mhatugade. "Hyaluronic Acid-Coated Nanoparticles Encapsulating Silymarin for Cancer Therapy." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 603–11. https://doi.org/10.35629/4494-1003603611.

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Cancer remains the leading cause of mortality globally, underscoring the urgent need for innovative therapeutic strategies. Among these strategies, nanoparticle technology has emerged as a promising avenue for cancer treatment. Recent advancements have enabled the modification of nanoparticles to exhibit favourable pharmacological properties through the incorporation of chemical ligands that specifically bind to receptors on the surface of malignant cells. The application of hyaluronic acid as a targeted ligand for nanoparticle coating presents a compelling alternative for active targeting. Th

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Ma, Yuanhui, Liping Zhang, Lei Wang, Lun Wang, and Hongqi Chen. "Preparation of gold nanoparticle coated NaYF4:Yb,Er,Gd nanoparticles and their application for AFP detection in the red region." Analytical Methods 9, no. 20 (2017): 2977–82. http://dx.doi.org/10.1039/c7ay00751e.

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A novel surface plasmon resonance (SPR) enhanced upconversion (UC) luminescence system was designed for the detection of α-fetoprotein (AFP) by using gold nanoparticle (NP) coated NaYF<sub>4</sub>:Yb,Er,Gd upconversion nanoparticles (UCNPs) as probes.

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Menendez-Miranda, Mario, José Manuel Costa-Fernández, Jorge Ruiz Encinar, Wolfgang J. Parak, and Carolina Carrillo-Carrion. "Determination of the ratio of fluorophore/nanoparticle for fluorescence-labelled nanoparticles." Analyst 141, no. 4 (2016): 1266–72. http://dx.doi.org/10.1039/c5an02405f.

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Nidianti, Ersalina, and Ary Andini. "UJI TOKSISITAS DENGAN METODE BSLT PADA NANOPARTIKEL KOMBINASI OBAT CISPLATIN, BOVINE SERUM ALBUMIN DAN ASAM FOLAT." Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 6, no. 1 (2021): 69–78. http://dx.doi.org/10.36387/jiis.v6i1.609.

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Cancer is a non-communicable disease that causes morbidity and mortality in all regions of the world. Cancer treatment is important in reducing the high number of deaths (mortality) due to cancer sufferers. One of the cancer treatments is using chemotherapy drug cisplatin. However, cisplatin drug has side effects, namely nephrotoxicity, ototoxicity, neurotoxicity, hemotoxicity, cardiotoxicity, and hepatotoxicity. Therefore, the combination of cisplatin in albumin nanoparticles and modification of the bond using folic acid as an alternative solution minimizes the resulting toxic effects. This s

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Fabbri, F., Elisabetta Borsella, M. Carpanese, et al. "Size and Surface Control of Optical Properties in Silicon Nanoparticles." Advances in Science and Technology 45 (October 2006): 2620–26. http://dx.doi.org/10.4028/www.scientific.net/ast.45.2620.

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Si-nanoparticles (NP) are attracting steadily growing interest due to their intriguing sizedependent optical properties. The most challenging task in preparing Si-NP is to succeed in controlling the particle size and size distribution and the surface properties. To this respect, the method of laser synthesis of Si-NP from gas phase reactants appears as an ideal tool, being a very versatile and controllable synthesis technique, but the collected Si-NP are strongly agglomerated. Here we report on attempts to decrease the agglomeration of the Si NP by following two complementary strategies: - inv

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de Barros, Dragana P. C., Luís P. Fonseca, Luís G. Gonçalves, Diogo S. Serrano, and Abel Oliva. "Design and Biocompatibility of Biodegradable Poly(octamethylene suberate) Nanoparticles to Treat Skin Diseases." Pharmaceutics 16, no. 6 (2024): 753. http://dx.doi.org/10.3390/pharmaceutics16060753.

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Biodegradable aliphatic polyester formulations as carriers for topical drug delivery show the potential to encapsulate structurally different therapeutic compounds. Poly(octamethylene suberate) (POS) nanoparticles (POS-NPs) were used as a matrix to encapsulate four therapeutic molecules used to treat skin disorders: caffeine (CF), quercetin (QR), hydrocortisone (HC), and adapalene (AD). Hydrophobicity and chemical structure of bioactive compounds (BCs) influenced the physicochemical stability of drug-loaded nanoparticles. The particle size of drug-loaded nanoparticles was between 254.9 nm for

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Cameron, Shana J., Jessica Sheng, Farah Hosseinian, and William G. Willmore. "Nanoparticle Effects on Stress Response Pathways and Nanoparticle–Protein Interactions." International Journal of Molecular Sciences 23, no. 14 (2022): 7962. http://dx.doi.org/10.3390/ijms23147962.

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Nanoparticles (NPs) are increasingly used in a wide variety of applications and products; however, NPs may affect stress response pathways and interact with proteins in biological systems. This review article will provide an overview of the beneficial and detrimental effects of NPs on stress response pathways with a focus on NP–protein interactions. Depending upon the particular NP, experimental model system, and dose and exposure conditions, the introduction of NPs may have either positive or negative effects. Cellular processes such as the development of oxidative stress, the initiation of t

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Ani, Hussam Nadum Abdalraheem Al, Anca Maria Cimbru, Szidonia Katalin Tanczos, et al. "Iono-molecular Separation with Composite Membranes III. Nitrophenols separation on polysulphone and composite nanoparticles ultrafiltration." Revista de Chimie 68, no. 3 (2017): 427–34. http://dx.doi.org/10.37358/rc.17.3.5470.

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Building on the excellent results of extraction on a solid phase (polymer) this work combine adsorption nitrophenols (a, m, p-nitrophenols) on polymeric nanoparticles (NP-PSf) and composite (NP-PSf-PANI) with colloidal ultrafiltration. Colloidal ultrafiltration solutions of nitrophenols is done in an ultrafiltration plant, CELF System, with a capacity of 500 mL at 25oC, variable working pressure (1-10 atmospheres), turbulent flow regime (2-4 m/s) and usable filter polysulfone-membrane composites 10% in dimethylformamide coagulated with methanol polyaniline (PANI-PSf) 15 cm2. Operational parame

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Kim, Tae‐Heon, Jesus A. I. Acapulco, Soonchang Hong, Sangji Lee, and Sungho Park. "Preparation of Two‐Dimensional Au Nanoparticle Arrays with Controllable Gap Distance: Interparticle Coupling Effect on Surface Plasmon Resonance and SERS^#." Bulletin of the Korean Chemical Society 36, no. 3 (2015): 815–21. http://dx.doi.org/10.1002/bkcs.10151.

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In this paper, we demonstrate the fabrication of highly ordered, close‐packed, two‐dimensional Au nanoparticle (2D Au NP) arrays by surface modification of Au NPs with self‐assembly chemistry of (3‐mercaptopropyl)‐trimethoxysilane (MPTMS) at a water/hexane interface. Aside from functioning as a packing molecule, MPTMS provided active sites for direct substrate polymerization of polydimethylsiloxane (PDMS). The optical properties of the fabricated 2D Au NP array were then analyzed by UV–vis‐NIR and Raman spectroscopy. The 2D Au NP array showed unique surface plasmon resonance (SPR) modes that c

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Kim, Dongyoon, Yina Wu, Gayong Shim, and Yu-Kyoung Oh. "Lipid Nanoparticle-Mediated Lymphatic Delivery of Immunostimulatory Nucleic Acids." Pharmaceutics 13, no. 4 (2021): 490. http://dx.doi.org/10.3390/pharmaceutics13040490.

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Lymphatic delivery of a vaccine can be achieved using a dendritic cell (DC)-targeted delivery system that can cause DC to migrate to lymph nodes upon activation by an adjuvant. Here, we designed a mannose-modified cationic lipid nanoparticle (M-NP) to deliver the nucleic acid adjuvant, polyinosinic:polycytidylic acid (PIC). PIC-loaded M-NP (PIC/M-NP) showed stable lipoplexes regardless of the ligand ratio and negligible cytotoxicity in bone marrow-derived DC. DC uptake of PIC/M-NP was demonstrated, and an increased mannose ligand ratio improved DC uptake efficiency. PIC/M-NP significantly prom

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Schvartz, Marion, Florent Saudrais, Yves Boulard, et al. "Dual Fractions Proteomic Analysis of Silica Nanoparticle Interactions with Protein Extracts." Materials 17, no. 19 (2024): 4909. http://dx.doi.org/10.3390/ma17194909.

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Dual-fraction proteomics reveals a novel class of proteins impacted by nanoparticle exposure. Background: Nanoparticles (NPs) interact with cellular proteomes, altering biological processes. Understanding these interactions requires comprehensive analyses beyond solely characterizing the NP corona. Methods: We utilized a dual-fraction mass spectrometry (MS) approach to analyze both NP-bound and unbound proteins in Saccharomyces cerevisiae sp. protein extracts exposed to silica nanoparticles (SiNPs). We identified unique protein signatures for each fraction and quantified protein abundance chan

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Ashoor, M., A. Khorshidi, and L. Sarkhosh. "Appraisal of new density coefficient on integrated-nanoparticles concrete in nuclear protection." Kerntechnik 85, no. 1 (2020): 9–14. http://dx.doi.org/10.1515/kern-2020-850104.

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Abstract The most important material for shielding is concrete in nuclear facilities which performance can be improved by addition some Nanoparticles (NP) at the various concentrations. Nanoparticles, which have a distinctive potential for bio-radiation and shielding of nuclear reactors, are used in many areas due to their special characteristics, which lead to an improvement in the mechanical properties and the pore structure of the concrete shield. The aim of this research was to initiate a novel coefficient (n), experiment to theory density ratio for integrated NP at different nanoparticle

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Minh, Nguyen Viet, Vu Ngoc Tuoc, and Le Thi Hong Lien. "Density Functional Based Tight Binding Study on Wurtzite ZnO Prismatic Nanoparticles." Communications in Physics 21, no. 3 (2011): 235. http://dx.doi.org/10.15625/0868-3166/21/3/173.

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We have performed the Density Functional Tight Binding (DFTB) study on the structural properties of Zinc Oxide Nanoparticles (NP), focusing on the effects induced by the surfaces and quantum size effect. Effects of surface relaxation and surface stress which is absent in atomistic model are taken carefully into account. The studying Nanoparticle size range up to 2.3nm. We illustrated the structural properties changes by decreasing NP sizes while the typical length of surface relaxation (about 1nm) remain unchanged and comparable with the particle size. The NP electronic properties, i.e. Densit

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