Academic literature on the topic 'Nucleophilic aromatic substitution'

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Journal articles on the topic "Nucleophilic aromatic substitution"

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Christoffers, Jens, and Mathias S. Wickleder. "Synthesis of Aromatic and Aliphatic Di-, Tri-, and Tetrasulfonic Acids." Synlett 31, no. 10 (2020): 945–52. http://dx.doi.org/10.1055/s-0039-1691745.

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Oligosulfonic acids are promising linker compounds for coordination polymers and metal-organic frameworks, however, compared to their carboxylic acid congeners, often not readily accessible by established synthetic routes. This Account highlights the synthesis of recently developed aromatic and aliphatic di-, tri- and tetrasulfonic acids. While multiple electrophilic sulfonations of aromatic substrates are rather limited, the nucleophilic aromatic substitution including an intramolecular variant, the Newman–Kwart rearrangement, allows the flexible introduction of up to four sulfur-containing m
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Liljenberg, Magnus, Tore Brinck, Tobias Rein та Mats Svensson. "Utilizing the σ-complex stability for quantifying reactivity in nucleophilic substitution of aromatic fluorides". Beilstein Journal of Organic Chemistry 9 (23 квітня 2013): 791–99. http://dx.doi.org/10.3762/bjoc.9.90.

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A computational approach using density functional theory to compute the energies of the possible σ-complex reaction intermediates, the “σ-complex approach”, has been shown to be very useful in predicting regioselectivity, in electrophilic as well as nucleophilic aromatic substitution. In this article we give a short overview of the background for these investigations and the general requirements for predictive reactivity models for the pharmaceutical industry. We also present new results regarding the reaction rates and regioselectivities in nucleophilic substitution of fluorinated aromatics.
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Zhang, Xiao, Guo-ping Lu, and Chun Cai. "Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: an electrophile–nucleophile dual activation by [Omim]Br for the reaction." Green Chemistry 18, no. 20 (2016): 5580–85. http://dx.doi.org/10.1039/c6gc01742h.

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Sadowsky, Daniel, Kristopher McNeill, and Christopher J. Cramer. "Dehalogenation of Aromatics by Nucleophilic Aromatic Substitution." Environmental Science & Technology 48, no. 18 (2014): 10904–11. http://dx.doi.org/10.1021/es5028822.

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Flippin, Lec A., David S. Carter, and Nathan J. P. Dubree. "Nucleophilic aromatic substitution on aromatic aldimines." Tetrahedron Letters 34, no. 20 (1993): 3255–58. http://dx.doi.org/10.1016/s0040-4039(00)73675-6.

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Li, Jinhua, Zhengyu Lu, Yuhui Hua, Dafa Chen, and Haiping Xia. "Carbolong chemistry: nucleophilic aromatic substitution of a triflate functionalized iridapentalene." Chemical Communications 57, no. 68 (2021): 8464–67. http://dx.doi.org/10.1039/d1cc03261e.

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Baum, James Clayton, Jimat Bolhassan, Richard Francis Langler, Paul Joseph Pujol, and Raj Kumar Raheja. "Sulfonyl esters. 2. CS cleavage in some substitution reactions of nitrobenzenesulfonates." Canadian Journal of Chemistry 68, no. 8 (1990): 1450–55. http://dx.doi.org/10.1139/v90-222.

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An attempt to explore aromatic sulfonate esters as agents for the condensation of alcohols with mercaptans revealed an unusual process for sulfonate esters: CS bond rupture. Two mechanistic possibilities for CS bond rupture are explored: (i) radical anion intermediacy via single electron transfer and (ii) nucleophilic aromatic substitution. Both experiments and molecular orbital computations are presented to support the conclusion that nucleophilic aromatic substitutions are occurring. Keywords: sulfonyl esters, nitrobenzenesulfonates, CS bond rupture.
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Garçon, Martí, Clare Bakewell, Andrew J. P. White, and Mark R. Crimmin. "Unravelling nucleophilic aromatic substitution pathways with bimetallic nucleophiles." Chemical Communications 55, no. 12 (2019): 1805–8. http://dx.doi.org/10.1039/c8cc09701a.

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Reaction of nucleophiles containing polar (Fe–Mg) and apolar (Mg–Mg) bonds with 2-(pentafluorophenyl)pyridine are calculated to proceed by stepwise and concerted S<sub>N</sub>Ar pathways respectively.
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Vasilenko, Dmitry A., Sevastian E. Dronov, Dzianis U. Parfiryeu, et al. "5-Nitroisoxazoles in SNAr reactions: access to polysubstituted isoxazole derivatives." Organic & Biomolecular Chemistry 19, no. 29 (2021): 6447–54. http://dx.doi.org/10.1039/d1ob00816a.

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An efficient protocol for the straightforward functionalization of the isoxazole ring via the reactions of aromatic nucleophilic substitution of the nitro group with various nucleophiles has been elaborated.
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Ajenjo, Javier, Martin Greenhall, Camillo Zarantonello, and Petr Beier. "Synthesis and nucleophilic aromatic substitution of 3-fluoro-5-nitro-1-(pentafluorosulfanyl)benzene." Beilstein Journal of Organic Chemistry 12 (February 3, 2016): 192–97. http://dx.doi.org/10.3762/bjoc.12.21.

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3-Fluoro-5-nitro-1-(pentafluorosulfanyl)benzene was prepared by three different ways: as a byproduct of direct fluorination of 1,2-bis(3-nitrophenyl)disulfane, by direct fluorination of 4-nitro-1-(pentafluorosulfanyl)benzene, and by fluorodenitration of 3,5-dinitro-1-(pentafluorosulfanyl)benzene. The title compound was subjected to a nucleophilic aromatic substitution of the fluorine atom with oxygen, sulfur and nitrogen nucleophiles affording novel (pentafluorosulfanyl)benzenes with 3,5-disubstitution pattern. Vicarious nucleophilic substitution of the title compound with carbon, oxygen, and
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Dissertations / Theses on the topic "Nucleophilic aromatic substitution"

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Kennedy, R. J. "Copper-promoted nucleophilic aromatic substitution." Thesis, University of Kent, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355148.

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Clough, Robert Steven. "The synthesis of aromatic polyethers by aromatic nucleophilic substitution." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1057072167.

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Martin, Peter Arnold. "Nucleophilic substitution reactions of some polyhalogenated compounds." Thesis, Durham University, 1987. http://etheses.dur.ac.uk/6876/.

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Rate measurements for the reactions of a series of polyfluoro - and polychloro - pyridines with aniline and ammonia in 60/40 dioxan/water at 25ºC has shown that chlorine, when ortho and para to the position of attack, is activating with respect to fluorine, but at the position meta to the point of attack, chlorine and fluorine are virtually equivalent in their effect on reaction rate. The trifluoromethyl and nitrile groups were found to be activating relative to fluorine when ortho and para to the position of substitution and the nitrile group was thus found to be ortho/para directing. The ort
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Jones, Craig Warren. "Nucleophilic aromatic substitution using supported copper(I) reagents." Thesis, University of York, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236184.

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Shen, Bin. "Studies on the nucleophilic aromatic 18 F-Fluorination from model compounds to aromatic amino acids /." [S.l. : s.n.], 2008.

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Donham, Leah L. "Gas-Phase Studies of Nucleophilic Substitution Reactions: Halogenating and Dehalogenating Aromatic Heterocycles." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5645.

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Halogenated heterocycles are common in pharmaceutical and natural products and there is a need to develop a better understanding of processes used to synthesize them. Although the halogenation of simple aromatic molecules is well understood, the mechanisms behind the halogenation of aromatic heterocycles have been more problematic to elucidate because multiple pathways are possible. Recently, new, radical-based mechanisms have been proposed for heterocycle halogenation. In this study, we examine and test the viability of possible nucleophilic substitution, SN2@X, mechanisms in the halogenat
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Smith, Philip Henry Gaunt. "An investigation of the preparation of heterocyclic ring systems via intramolecular nucleophilic aromatic substitution." Thesis, Loughborough University, 1985. https://dspace.lboro.ac.uk/2134/10458.

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Heterocyclic synthesis via processes involving single electron transfer, namely aromatic SRN1 ,reactions and copper metal- and cuprous halide-promoted substitutions have been investigated. The cyclisation step in all the 'syntheses is effected by an intramolecular aromatic nucelophilic substitution on a halogen atom which is ortho to the side chain bearing the nucleophilic species (generally an amide or thioamide moiety). The process of entrainment has been shown to be a valuable technique for effecting reactions performed' under SRN1 conditions. The mechanisms of, and the mechanistic relation
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Serve', Brian J. "RUTHENIUM-MEDIATED NUCLEOPHILIC AROMATIC SUBSTITUTION OF HALOGENS ON BENZENE SYSTEMS: SYNTHESIS OF 1,3,5-TRIAMINOBENZENES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1152813193.

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Schory, David Henry. "Quantum Chemical Investigations of Nucleophilic Aromatic Substitution Reactions and Acid Dissociations of Aliphatic Carboxylic Acids." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1253480264.

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Liu, Jiangqiong. "Kinetic Studies of 6-Halopurine Nucleoside in SNAr Reactions; 6-(Azolyl, Alkylthio and Fluoro)-purine Nucleosides as Substrates for Suzuki Reactions." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1821.pdf.

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Books on the topic "Nucleophilic aromatic substitution"

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Terrier, François. Modern Nucleophilic Aromatic Substitution. Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527656141.

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N, Charushin Valery, and Plas, H. C. van der., eds. Nucleophilic aromatic substitution of hydrogen. Academic Press, 1994.

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Nucleophilic aromatic displacement: The influence of the nitro group. VCH Publishers, 1991.

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Burgers, Martijn Hendrik Willem. Zeolite-catalyzed nucleophilic aromatic substitution reactions =: Nucleofiele aromatische substitutie-reakties gekatalyseerd door metaalhoudende zeolieten. Delft University Press, 1995.

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Burgers, Martijn Hendrik Willem. Zeolite-catalyzed nucleophilic aromatic substitution reactions =: Nucleofiele aromatische substitutie-reakties gekatalyseerd door metaalhoudende zeolieten. Delft University Press, 1995.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Incorporated, John, 2013.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Incorporated, John, 2013.

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Modern Nucleophilic Aromatic Substitution. Wiley-VCH Verlag GmbH, 2013.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Limited, John, 2013.

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Terrier, Francois. Modern Nucleophilic Aromatic Substitution. Wiley & Sons, Incorporated, John, 2013.

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Book chapters on the topic "Nucleophilic aromatic substitution"

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470975800.ch5.

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Norman, Richard, and James M. Coxon. "Nucleophilic aromatic substitution." In Principles of Organic Synthesis. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-2166-8_12.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms · 2008. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470979525.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119972471.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118560273.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms 2001. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470866748.ch5.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781119941910.ch5.

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Crampton, Michael R. "Nucleophilic Aromatic Substitution." In Arene Chemistry. John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118754887.ch6.

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Crampton, M. R. "Nucleophilic Aromatic Substitution." In Organic Reaction Mechanisms Series. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470022051.ch5.

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Caron, Stéphane, and Arun Ghosh. "Nucleophilic Aromatic Substitution." In Practical Synthetic Organic Chemistry. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118093559.ch4.

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Conference papers on the topic "Nucleophilic aromatic substitution"

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VO-THANH, Giang, and Alain PETIT. "Solvent-Free Microwaves Assisted Amination of Haloarenes by Aromatic Nucleophilic Substitution." In The 15th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2011. http://dx.doi.org/10.3390/ecsoc-15-00763.

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