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Dissertations / Theses on the topic 'Nutrigenomic'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Ostertag, Luisa Martha. "The impact of dietary polyphenols on human platelets : integrating functional and nutrigenomic analyses." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=185749.

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This thesis aims to integrate functional and nutrigenomics analyses to examine how dietary polyphenols affect human platelet function and thus may contribute to the prevention of cardiovascular diseases. Initially, 26 low molecular weight phenolic compounds were screened for their effects on platelet aggregation and P-selectin expression in vitro. Only high, non-physiological concentrations of some phenolics showed anti-platelet effects. In parallel we conducted a systematic review of the literature to assess how polyphenol-rich foodstuffs, beverages, or extracts affect platelet function in hu

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2

Sánchez, González Claudia Alejandra. "Nutrigenomic approach to study the potential role of walnut polyphenols and their human metabolites in cancer prevention and treatment." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/315837.

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Epidemiologic studies and clinical trials have demonstrated consistent benefits of walnut (Juglans regia L.) consumption. Walnuts have been described as a rich source of polyphenols with a broad array of different structures. However, an accurate screening of its complete phenolic profile was lacking. Using liquid chromatography coupled with electrospray ionization hybrid linear trap quadrupole-Orbitrap mass spectrometry (LC–LTQ-Orbitrap) a comprehensive identification of phenolic compounds in walnuts was performed. A total of 120 compounds were identified, with ellagitannins, ellagic acid and

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3

Frahnow, Turid [Verfasser], and Matthias Bernd [Akademischer Betreuer] Schulze. "Bioinformatische Analyse der NUGAT-Studie (NUtriGenomic Analysis in Twins) : Verfahren zur Integration lipidomischer, transkriptomischer und metabolischer Daten / Turid Frahnow ; Betreuer: Matthias Bernd Schulze." Potsdam : Universität Potsdam, 2016. http://d-nb.info/121840194X/34.

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4

Joumard-Cubizolles, Laurie. "Propriétés anti-athérogènes du DHA : effets nutrigénomiques au niveau aortique et rôle potentiel des métabolites issus de la peroxydation." Thesis, Clermont-Ferrand 1, 2013. http://www.theses.fr/2013CLF1MM17.

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Les acides gras polyinsaturés oméga-3 à longue chaîne (AGPIω3-LC), principalement représentés par l'acide eicosapentaénoïque (EPA) et l'acide docosahexaénoïque (DHA), présentent des effets bénéfiques vis-à-vis de l'athérosclérose. Leur action au niveau vasculaire est suggérée. Les mécanismes d'action sont mal compris du fait de la complexité d'action des AGPIω3-LC au niveau cellulaire. Les AGPIω3-LC affectent de nombreuses protéines y compris les facteurs de transcription, ce qui engendre la modulation de l'expression de nombreux gènes. La complexité s'accroît si l'on considère l'ensemble des

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Tacchi, Luca. "Molecular basis of improved feeds for aquaculture : a nutrigenomics approach." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=179562.

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The growth of aquaculture industry, and in particular of salmonids, has dramatically increased in the last decades to supply the growing worldwide demand for fish products. The expansion of aquaculture needs a good management to ensure the sustainability of this activity. In particular, improving feeds for aquaculture to enhance health and performance of reared fish is imperative for this industry. Molecular biological approacches can help interpret responses to new diets and immune responses. Ubiquitin ligases (UbE3s) play a pivotal role in the ubiquitin proteasome pathway of protein degradat

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6

NASELLI, Flores. "NUTRIGENOMICS EFFECTS OF PHYTOCHEMICAL INDICAXANTHIN IN in vitro CELL SYSTEMS." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/90899.

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Nutrition plays a key role in many aspects of health, indeed epidemiological studies provide evidence that diet can play essential roles in reducing the risk of chronic diseases. Accumulating evidence indicates that dietary compounds (phytochemicals) from fruit and vegetables can modulate multiple cancer-inflammation pathways which are relevant for chemoprevention and are commonly deregulated by epigenetic mechanisms in cancer cells, including drug detoxification, cell cycle regulation, apoptosis induction. Epigenetic refers to heritable alterations in gene expression that do not involve

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7

Grosh, Kimberly Coile. "Nutrigenomics and Nutritional Epigenetics – The State of the Science in Academia." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1308247018.

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8

Chankova, Nelly. "Establishing the influence of dietary fatty acids on the colon through nutrigenomics." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/establishing-the-influence-of-dietary-fatty-acids-on-the-colon-through-nutrigenomics(26dc700d-4e62-420c-959d-2dcab0cb363a).html.

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Introduction: The fatty acid (FA) composition of the diet can have both a positive and negative impact on the health and wellbeing of an individual. Diets rich in saturated FAs and cholesterol promote cardiovascular disease, while diets rich in omega 3 FA protect against cardiovascular disease. Diets rich in omega 6 FAs are thought to have pro-inflammatory and promoting properties, while diets rich in omega 3 FAs have anti-inflammatory and chemo preventative qualities. The increase of the ratio of omega 6 to omega 3 FAs is an important factor in the increased incidence of inflammatory diseases

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9

Quinn, Peter. "Applications of functional nutrition and nutrigenomics to improve public health through dietary interventions." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3023632/.

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Diet and lifestyle factors are well documented for their impact on health and wellbeing. Epigenetics provides the added connection between personal genetics and environmental factors, including food, interacting with health and disease. Functional foods is a growth area of food development, augmentation and supplementation. However, more scientific validation of the claims made for functional foods and functional components is required to properly inform consumers and healthcare practitioners. There is also growing consumer acceptance of personalised genetic analysis for health and wellbeing.

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10

Montesano, A. "LA NUTRIGENOMICA NEL DIFFERENZIAMENTO MUSCOLARE SCHELETRICO: RUOLO DEL RESVERATROLO NEL PROCESSO DI MIOGENESI ED IPERTROFIA IN MIOBLASTI MURINI." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217719.

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ABSTRACT Nutrigenomics in musculoskeletal differentiation: Resveratrol action on myogenesis process and hypertrophy induction in C2C12 myoblasts The new era of nutrition research translates empirical knowledge to evidence-based molecular science, because food components interact with our body at system, organ, cellular and molecular level. Modern nutrition research focuses on promoting health, preventing or delaying the onset of disease, optimizing performance and assessing risk. Nutrigenomics studies elucidate the ability of bioactive food components to influence gene expression pa

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11

Tarasov, Stanislav. "Business solution for a food service company based on a modern nutrition concept (case of Russia)." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-114364.

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Increasing level of public concerns about ageing and obesity problems accompanied by the advent of more and more health conscious consumers have put a priority on the health and wellness industry development which has started transformation from a niche category towards the mainstream. As a human being is an individual with unique known characteristics (like age, gender, health state, lifestyle) and less known characteristics like a genetic predisposition, the nutrition plan should be designed around these characteristics. Being aware of genetic predisposition of an individual allows to develo

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12

BOMBA, LORENZO. "Effect of dietary changes during weaning on gut gene expression in animal models." Doctoral thesis, Università Cattolica del Sacro Cuore, 2012. http://hdl.handle.net/10280/1314.

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Una dieta scorretta incrementa il rischio di malattie come l’insulino resistenza e l’obesità. Questa tesi ha l’obiettivo di valutare l’effetto di diete sbilanciate sulla fisiologia ed espressione genica in topi e suini allo svezzamento. Topi C57BL/6 sono stati sacrificati dopo 2 settimane, dopo essere stati alimentati con dieta iper-lipidica e dieta controllo. L’espressione genica è stata stimata usando la tecnologia microarray. Quattro dei sette geni identificati differenzialmente espressi tra il controllo e l’iper-lipidico sono coinvolti nella regolazione della via metabolica del sistema cir

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13

BOMBA, LORENZO. "Effect of dietary changes during weaning on gut gene expression in animal models." Doctoral thesis, Università Cattolica del Sacro Cuore, 2012. http://hdl.handle.net/10280/1314.

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Una dieta scorretta incrementa il rischio di malattie come l’insulino resistenza e l’obesità. Questa tesi ha l’obiettivo di valutare l’effetto di diete sbilanciate sulla fisiologia ed espressione genica in topi e suini allo svezzamento. Topi C57BL/6 sono stati sacrificati dopo 2 settimane, dopo essere stati alimentati con dieta iper-lipidica e dieta controllo. L’espressione genica è stata stimata usando la tecnologia microarray. Quattro dei sette geni identificati differenzialmente espressi tra il controllo e l’iper-lipidico sono coinvolti nella regolazione della via metabolica del sistema cir

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14

Vaqué, Marquès Montserrat. "In silico studies of the effect of phenolic compounds from grape seed extracts on the activity of phosphoinositide 3-kinase (PI3K) and the farnesoid x receptor (FXR)." Doctoral thesis, Universitat Rovira i Virgili, 2007. http://hdl.handle.net/10803/8664.

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In silico studies of the effect of phenolic compounds from grape seed extracts on the activity of phosphoinositide 3-kinase (PI3K) and farnesoid X receptor (FXR)<br/><br/>Montserrat Vaqué Marquès <br/>En aquesta tesis es pretén aplicar metodologies computacionals (generació de farmacòfors i docking proteïna lligand) en l'àmbit de la nutigenòmica (ciència que pretén entendre, a nivell molecular, com els nutrients afecten la salut). S'aplicaran metodologies in silico per entendre a nivell molecular com productes naturals com els compostos fenòlics presents en la nostra dieta, poden modular la fu

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15

Landell, Carolina de Almeida Coelho. "Proteômica em dois grupos metabólicos de crianças e adolescentes com diferente perfil lipídico e glicídico submetidos à suplementação de micronutrientes." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17144/tde-06042018-104807/.

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Introdução: Conhecer as respostas proteômicas de diferentes grupos metabólicos após uma intervenção nutricional poderia ajudar a identificar biomarcadores e o tratamento dietético mais apropriado para diferentes perfis de indivíduos. Objetivos: Descrever dois diferentes grupos metabólicos em um estudo de intervenção nutricional; descrever o perfil lipídico, os níveis de glicose e os dados proteômicos ao longo do estudo nesses dois grupos. Metodologia: Foi realizado um estudo de intervenção \"N-of-1\", com indivíduos de 9 a 13 anos, no qual ocorreu avaliação antropométrica, de composição corpor

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Coelho, Carolina de Almeida. "Perfil metabólico e do estado nutricional de crianças e adolescentes de escolas da cidade de Ribeirão Preto, São Paulo, Brasil." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17144/tde-11032014-090751/.

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Introdução: Poucos trabalhos correlacionam o perfil metabólico com o estado nutricional em crianças e adolescentes após intervenção dietética. Objetivos: Identificar, em uma população de indivíduos de 9 a 13 anos submetidos a uma intervenção nutricional, a existência de diferentes grupos metabólicos formados com base em dados bioquímicos (níveis de glicemia, colesterol total, triglicérides, VLDL colesterol, LDL colesterol e HDL colesterol) coletados em 3 momentos do estudo; e descrever a evolução longitudinal do perfil nutricional e metabólico destes grupos. Metodologia: Estudo clínico de inte

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17

Lima, Ana Rita da Cunha. "Nutrigenómica." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4430.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>Numa sociedade cada vez mais preocupada com a saúde, a nutrição tem desempenhado um papel muito importante, não só com a causa da doença, mas também como uma forma de prevenção da doença. Isto ocorre porque os nutrientes são capazes de interagir com os mecanismos moleculares do organismo e assim, modificar as funções fisiológicas. A nutrigenómica (o estudo dos nutrientes na expressão dos genes) pode assim ser explorada de duas f

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18

Wilkins, Julianne G. "Knowledge and Perception of College Students Toward Genetic Testing for Personalized Nutrition Care." Kent State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1491906065477344.

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19

Almeida, Mara Ribeiro de. "Avaliação da citotoxicidade, genotoxicidade, antigenotoxicidade e expressão dos genes Tp53 e Ephx2 em ratos tratados com Caryocar villosum." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-21062013-101342/.

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O consumo de frutas e verduras está relacionado com a promoção da saúde porque tem sido associado com a redução do risco de desenvolvimento de doenças crônicas como, por exemplo, câncer e doenças degenerativas e cardiovasculares. Dessa forma, o estudo dos efeitos biológicos desses alimentos tem ganhado atenção nos últimos anos. O piquiá (Caryocar villosum) é um fruto nativo da Amazônia e é rico em compostos antioxidantes como os compostos fenólicos. Assim, o objetivo deste estudo foi avaliar os efeitos genotóxicos e antigenotóxicos in vivo da polpa liofilizada do piquiá e também de seu extrato

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20

Machado, Carla da Silva. "Avaliação da instabilidade genômica, estresse oxidativo e modulação da expressão gênica pela vitamina D em modelo de ratos espontaneamente hipertensos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-04012017-094931/.

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A vitamina D3 é um micronutriente obtido da dieta ou pela conversão do 7- dehidrocolesterol na epiderme após exposição à radiação UVB. A vitamina D (D2 ou D3) atua sobre o sistema renina-angiotensina-aldosterona, e sua deficiência vem sendo associada ao desenvolvimento da hipertensão. O objetivo deste estudo foi avaliar o efeito da suplementação ou deficiência de vitamina D3 em ratos espontaneamente hipertensos (SHR - spontaneously hypertensive rats) e seus controles normotensos (Wistar Kyoto - WKY) sobre a pressão arterial sistólica, danos ao DNA e cromossomos, marcadores bioquímicos do estre

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Serpeloni, Juliana Mara. "Atividade antigenotóxica de compostos da dieta e sua influência na expressão de genes de resposta ao estresse oxidativo." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-04072012-111234/.

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Os pigmentos naturais, além de fornecerem cor e beleza aos diferentes organismos, desempenham importantes funções e ações biológicas, como as funções vitais de fotossíntese, respiração celular e a ação antioxidante. Assim, o presente estudo investigou os potenciais citotóxicos, genotóxicos e protetores dos pigmentos naturais clorofila b (CLb) e luteína (LT), isolados e em combinação, em doses normalmente consumidas na dieta. Para isso foram utilizados o teste do micronúcleo em células da medula óssea e do sangue periférico e o ensaio cometa em células do sangue periférico, rim e fígado de camu

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Pinto, Fabio Henrique Villa. "Avaliação dos efeitos da curcumina sobre a hepatotoxicidade induzida pelo mercúrio em células humanas HepG2." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-25092015-144327/.

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O mercúrio é um dos metais mais nocivos presentes no ambiente, advindo tanto de fontes naturais quanto antropogênicas. Os indivíduos estão expostos a diferentes formas do mercúrio através de diversas vias, como a alimentação, principalmente no caso do metilmercúrio presente em peixes. Suas formas orgânicas são muito significativas do ponto de vista toxicológico, considerando-se a exposição da população e seus efeitos pró-oxidantes e genotóxicos envolvidos na origem de inúmeras doenças. Por outro lado, é suposto que compostos polifenólicos e outros antioxidantes da dieta podem exercer atividade

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23

Fernandes, Carolina da Silva. "Nutrigenómica: da nutrição moderna a Lamark." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4860.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A nutrigenómica estuda o conjunto de alterações que os nutrientes podem causar sobre o genoma humano. Estas alterações podem desencadear diversas alterações no fenótipo expresso, como por exemplo um aumento da propensão para doenças crónicas como a diabetes ou a obesidade. Os estudos nutrigenómicos avaliam também as várias alterações que ocorrem no genoma e epigenoma e como a nutrição pode moldar estas alterações. O ácido fólico

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Shiyab, Amy S. "Knowledge and Perception of Nutritional Genomics Among Registered Dietitian Nutritionists." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1563187321042113.

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Massucci, Toledo Tarik. "Effect of dietary lipid on the molecular and metabolic profile of a freshwater crayfish." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/134470/1/Tarik_Massucci%20Toledo_Thesis.pdf.

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As global fisheries decline, increasing attention is being directed towards the aquaculture industry to reduce the consumption of fish oil, leading to the substitution of vegetable oils in formulated diets. This project examines the effect of diet on the ability of red claw crayfish, a commercial aquaculture species in Australia, to synthesise the fatty acids essential for normal growth and development. Based on the metabolic activity and gene expression analysis, outcomes suggest that fish oil can be substituted with sunflower oil in the formulation of crayfish diets for this important aqua

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Alencar, Luciane Luca de. "Estudo dos polimorfismos Pro198Leu no gene da glutationa peroxidase 1 e -617C/A no gene do fator de transcrição Nrf2 com relação ao estresse oxidativo e ao estado nutricional relativo ao selênio de pacientes com diabetes mellitus tipo 1." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9132/tde-27052015-142459/.

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Estudos têm mostrado que a atividade da enzima glutationa peroxidase (GPx) se encontra reduzida na presença do polimorfismo de nucleotideo único (SNP) Pro198Leu no gene que codifica para a GPx1. Associado a isso, polimorfismos na região promotora do gene do fator de transcrição Nrf2, o qual se liga ao elemento de resposta antioxidante na via de expressão de genes de enzimas antioxidantes, também pode alterar a expressão gênica da GPx1. Como o mineral selênio faz parte do sítio catalítico desta enzima antioxidante, muitos estudos têm associado o estado nutricional relativo a este nutriente com

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Patricio, Roberta Saraiva Giroto. "Desenvolvimento de material educativo digital para divulgação científica da nutrigenômica." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/9/9132/tde-19102010-161224/.

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Nutrigenômica representa disciplina cientifica recente que surgiu na era do pós-genoma humano, sendo seu foco de estudo a interação gene - nutriente. Profissionais com educação universitária que atuam na área da alimentação e nutrição e da saúde relatam ter dificuldades no entendimento dos princípios dessa disciplina. Recursos digitais como animações representam ferramentas interessantes para o processo de ensino-aprendizagem da nutrigenômica. Dessa forma o objetivo do presente trabalho foi o de desenvolver material educativo digital intitulado \"Fundamentos da Nutrigenômica\", baseado nas an

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Pouille, Céline. "Effets de la chicorée sur la santé animale." Electronic Thesis or Diss., Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILR076.

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Ce projet s'inscrit dans une problématique globale qui concerne la caractérisation du potentiel nutrition-santé des produits agro-alimentaires issus de la biodiversité naturelle de la chicorée ainsi que des variétés améliorées de celle-ci. L'enjeu consiste à valoriser les produits conventionnels et surtout ceux à valeur d'aliment fonctionnel, qui procurent, au-delà des fonctions nutritionnelles de base, des bienfaits physiologiques et qui réduisent le risque de maladies chroniques.L'objectif de ce projet de thèse a été de tester différents produits issus de la chicorée industrielle (Cichorium

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Almeida, Danielle Fontes de. "Avaliação do perfil de expressão gênica de linhagens celulares do tecido mamário com diferentes níveis de expressão do receptor HER-2 tratadas com ácido docosahexaenoico." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-08082013-092359/.

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O câncer de mama permanece como segundo tipo de câncer mais frequente no mundo e o primeiro entre as mulheres. Tumores de mama podem ser categorizados pela expressão de receptores como o HER-2 (receptor de fator de crescimento epidermal 2). A hiperexpressão do receptor HER-2 é observada em cerca de 30% dos carcinomas de mama, e está associada a prognósticos desfavoráveis. Os ácidos graxos poli-insaturados (AGPI) , como os ácidos graxos ômega-3, parecem diminuir o risco de câncer de mama. O ácido docosahexaenoico (DHA), um tipo de AGPI ômega-3 parece ter o maior potencial antitumoral no câncer

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Oleaga, Sancho Carlota. "Estudio nutrigenómico de compuestos polifenólicos del cacao y del café en células tumorales humanas." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/96129.

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La investigación en genómica nutricional combina las áreas de conocimiento de biología molecular, genética y nutrición. Los compuestos bioactivos de la dieta se podrían definir como aquellos componentes con potencial para modificar un elevado número de procesos biológicos asociados al equilibrio entre salud y enfermedad. En la presente tesis se han desarrollado tres estudios nutrigenómicos con compuestos polifenólicos del cacao y del café, con el objetivo de profundizar en el conocimiento de los mecanismos de acción por los que ejercen su actividad. En el estudio de los efectos de un extrac

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Konstantinidou, Valentini. "Molecular mechanisms involved in the protective effect of Mediterranean diet and olive oil consumption in humans." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7208.

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The scope of the present work was to investigate whether the protective role of the traditional Mediterranean diet (TMD), and virgin olive oil (VOO) rich in phenolic compounds (PC), towards cardiovascular disease can be mediated through gene expression changes. Two trials were performed to assess the in vivo nutrigenomic effects of TMD and VOO in healthy volunteers. The results point out: a) significant gene expression changes of those genes related with cardiovascular-risk processes after VOO ingestion; b) a down-regulation in the expression of atherosclerosis-related genes after a 3-month in

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Castro, Rita de Cássia Borges de. "Efeito do ácido docosahexaenoico (DHA) sobre eventos epigenéticos em diferentes linhagens de câncer de mama." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-03102013-094648/.

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Alterações epigenéticas, como metilação do DNA e modificações pós traducionais em histonas, tem importante papel na carcinogênese mamária. A modulação de eventos epigenéticos constitui relevante alvo terapêutico, devido ao seu caráter reversível. Experimentalmente, o ácido docosahexaenoico (DHA), um membro da família dos ácidos graxos ômega-3, é capaz de diminuir proliferação, induzir morte celular e diminuir o potencial invasivo de células tumorais de mama. No entanto, os mecanismos antitumorais do DHA e sua capacidade de modular eventos epigenéticos ainda não estão totalmente elucidados. Nos

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Fontaine-Bisson, Benedicte. "Nutrigenomics, inflammation and biomarkers of cardiovascular disease." 2008. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=742613&T=F.

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Furness, Denise Lyndal Fleur. "Genome damage and folate nutrigenomics in uteroplacental insufficiency." 2007. http://hdl.handle.net/2440/57508.

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Pregnancy complications associated with placental development affect approximately one third of all human pregnancies. Genome health is essential for placental and fetal development, as DNA damage can lead to pregnancy loss and developmental defects. During this developmental phase rapid DNA replication provides an increased opportunity for genome and epigenome damage to occur[1]. Maternal nutrition is one of the principal environmental factors supporting the high rate of cell proliferation and differentiation. Folate functions in one-carbon metabolism and regulates DNA synthesis, DNA repair a

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Krupková, Lucie. "Nutrigenetické a nutrigenomické aspekty u vybraných patologií." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279562.

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DIPLOMA THESIS Nutrigenetic and nutrigenomic aspects at selected pathological states. Mentor of Diploma Thesis: PharmDr. Miloslav Hronek, Ph.D. Lucie Krupková, 2010 Abstract The effect of nutrition to human health is undisputable. Certain dietary compounds can influence each of us in different ways. Although people have almost identical genome, there are imperceptible diffenrences that make us unique. This uniqueness is shown in different responses to specific nutrients. The matter of diet, genes and gen-diet interactions are solved by two developing scientific disciplines - nutrigenomics and

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Wong, Monica. "Cluster Analyses to Assess Weight Loss Maintenance: An Application of Clustering in Nutrigenomics." Thesis, 2011. http://hdl.handle.net/10214/2860.

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Within nutrigenomics, clustering using data generated by microarray gene expression profiles can be used to identify sub-populations of subjects that respond differently to a given diet intervention. The use of clustering analyses is promising in obesity-related research as personalized nutrition is gaining popularity. This thesis focuses on clustering a human subcutaneous adipose tissue gene expression data set obtained during a low-calorie diet intervention to aid in the prediction of 6-month weight loss maintenance. The aims of the study were (1) to identify the best performing clusterin

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Yeh, Chi-Tai, and 葉淇臺. "Nutrigenomics approach to understanding the role of dietary phenolic acids in sulfate conjugation." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/51303625552550282285.

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博士<br>國立中興大學<br>食品科學系<br>93<br>Abstract Sulfation (sulfonation) is one of the major phase II conjugative reactions involved in the biotransformation of various endogenous compounds, drugs, and xenobiotics as well as in steroid biosynthesis, catecholamine metabolism, and thyroid hormone homeostasis. Phenolic acids such as hydroxybenzoic acids and hydroxycinnamic acids are antioxidant compounds in fruits and vegetables. Research on phenolic acids is of current interest due to the important biological and pharmacological properties attributed to their antioxidant properties. Therefore, the obj

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Abrahams, Mariëtte, L. J. Frewer, Eleanor J. Bryant, and Barbara Stewart-Knox. "Perceptions and experiences of early-adopting registered dietitians in integrating nutrigenomics into practice." 2017. http://hdl.handle.net/10454/13480.

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yes<br>Purpose - This research explores the perceptions and experiences of early adopters of the technology. Design/Method/Approach - Registered Dietitians (RD´s) (N=14) were recruited from the UK, Canada, South-Africa, Australia, Mexico and Israel. Six qualitative interviews and two focus groups were conducted online using a conference calling platform. Data were recorded, transcribed and thematically analysed. Findings - Early adopters of Nutrigenomics (NGx) were experienced, self-efficacious RD’s who actively sought knowledge of NGx through communication with one another and the bro

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Su, Hsiang-Ling, and 蘇香綾. "Exploring the Consumer Acceptance Of and Preferences In Nutrigenomics-Based Personalized Health Management Service." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/86914301908026322071.

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碩士<br>國立中興大學<br>科技管理研究所<br>100<br>Nutrigenomics is an emerging technology that offers opportunities for personalized health management from the preventive and promoting perspectives. Despite general agreement on the value of nutrigenomics as a powerful approach to unravel the complex diet-health relationships, challenges in applications at the scientific, regulative, and ethical levels have also been widely discussed. However, research into the consumer acceptance and potential service models of such application is relatively scarce. As the awareness and demand for preventive medicine conti

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Eny, Karen M. "Genetic Determinants of Carbohydrate Consumption." Thesis, 2010. http://hdl.handle.net/1807/26147.

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Background: There are a number of biological pathways that affect our ingestive behaviours, including energy homeostasis, food reward, and taste. Given that carbohydrates such as sugars, provide energy and a sweet taste, examining candidate genes in each pathway may help explain differences in carbohydrate consumption behaviours. Objective: To determine whether variations in genes encoding a glucose transporter (GLUT2), a dopamine receptor (DRD2), and sweet taste receptor (TAS1R2) are associated with differences in sugar consumption in two distinct populations. Methods: Population 1 includ

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Asik, Christine Rose. "Genetic Variation in Bitter Taste Perception, Food Preference and Dietary Intake." Thesis, 2010. http://hdl.handle.net/1807/32204.

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The role of variation in the TAS2R50 bitter taste receptor gene is unknown, but may influence taste perception and dietary habits. Individuals (n=1171) aged 20 to 29, from the Toronto Nutrigenomics and Health Study, completed a food preference checklist and a semi-quantitative food frequency questionnaire to assess their preference and intake of potentially bitter foods and beverages. DNA was isolated from blood and genotyped for 3 polymorphisms in the TAS2R50 gene (rs2900554 A>C; rs10772397 A>G; rs1376251 A>G). Taste intensity was examined using taste strips infused with 3µg of naringin. The

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Stewart-Knox, Barbara, Jerko Markovina, A. Rankin, et al. "Making personalised nutrition the easy choice: creating policies to break down the barriers and reap the benefits." 2016. http://hdl.handle.net/10454/8904.

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Yes<br>Personalised diets based on people’s existing food choices, and/or phenotypic, and/or genetic information hold potential to improve public dietary-related health. The aim of this analysis, therefore, has been to examine the degree to which factors which determine uptake of personalised nutrition vary between EU countries to better target policies to encourage uptake, and optimise the health benefits of personalised nutrition technology. A questionnaire developed from previous qualitative research was used to survey nationally representative samples from 9 EU countries (N = 9381). P

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Školníková, Elena. "Nutrigenomická analýza vlivu diety v průběhu prenatálního a časného vývoje na manifestaci aspektů metabolického syndromu v dospělosti." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-437899.

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16 Abstract The rising prevalence in noncommunicable diseases worldwide calls for the effort to determine their underlying causes. Common metabolic disorders in particular overwhelm the healthcare systems and are a one of the leading causes of poor quality of life of patients. Metabolic syndrome is represented by concurrence of several conditions - dyslipidaemia, obesity, hypertension or impaired glucose tolerance - altered metabolic phenotypes related to genetic and environmental factors. Recent studies suggest that early-life exposure to certain environmental stimuli is particularly capable

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Brathwaite, Joanne Margaret. "Genetic Variability in Caffeine Acute Effects and Withdrawal Symptoms." Thesis, 2011. http://hdl.handle.net/1807/29497.

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The mechanisms underlying caffeine’s acute effects and withdrawal symptoms are not entirely understood. The purpose was to determine whether the clusters of acute effects or withdrawal symptoms are associated with genetic polymorphisms in DARPP-32 and COMT, which mediate some of caffeine’s physiological effects. Subjects (n=1135) were from the Toronto Nutrigenomics and Healthy Study. Fourteen well-described acute effects of caffeine co-exist in six groups, while fourteen well-characterized withdrawal symptoms co-exist in three groups. Neither the rs907094 C>T polymorphism in the PPP1R1B gene e

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Nicolaou, Anna, S. M. Pilkington, L. E. Rhodes, and R. B. Watson. "Omega-3 Polyunsaturated Fatty Acids: Photoprotective Macronutrients." 2011. http://hdl.handle.net/10454/5227.

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No<br>Ultraviolet radiation (UVR) in sunlight has deleterious effects on skin, while behavioural changes have resulted in people gaining more sun exposure. The clinical impact includes a year-on-year increase in skin cancer incidence, and topical sunscreens alone provide an inadequate measure to combat overexposure to UVR. Novel methods of photoprotection are being targeted as additional measures, with growing interest in the potential for systemic photoprotection through naturally sourced nutrients. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are promising candidates, showing potential to

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Fallaize, R., A. L. Macready, L. T. Butler, et al. "The perceived impact of the National Health Service on personalised nutrition service delivery among the UK public." 2015. http://hdl.handle.net/10454/7211.

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Yes<br>Personalised nutrition (PN) has the potential to reduce disease risk and optimise health and performance. Although previous research has shown good acceptance of the concept of PN in the UK, preferences regarding the delivery of a PN service (e.g. online v. face-to-face) are not fully understood. It is anticipated that the presence of a free at point of delivery healthcare system, the National Health Service (NHS), in the UK may have an impact on end-user preferences for deliverances. To determine this, supplementary analysis of qualitative data obtained from focus group discussions

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Rankin, A., B. P. Bunting, R. Poinhos, et al. "Food choice motives, attitudes toward and intention to adopt personalised nutrition." 2018. http://hdl.handle.net/10454/15509.

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yes<br>Objective: This study explored associations between food choice motives, attitudes towards, 5 and intention to adopt personalised nutrition in order to inform communication strategies 6 based on consumer priorities and concerns. Design and Setting: A survey was administered 7 online which included the food choice questionnaire (FCQ), and items assessing attitudes 8 towards and intention to adopt personalised nutrition. Participants: Nationally representative 9 samples were recruited in 9 EU countries (N=9381). Results: Structural equation modelling 10 indicated that the food choic

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Beckett, Emma Louise. "Folate and vitamin D: the role of nutritional status and nutrigenetics in predicting levels of extracellular microRNA and circulating DNA methylation status." Thesis, 2016. http://hdl.handle.net/1959.13/1316824.

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Research Doctorate - Doctor of Philosophy (PhD)<br>microRNA (miRNA) in systemic circulation are proposed as potential biomarkers for disease diagnosis and prognosis. However, miRNA profiles may also be modulated by other exposures such as nutritional status, and this may have consequences for use of miRNA as biomarkers, particularly in diseases for which diet is a modifiable determinant. Furthermore, little is known about the interactions that exist between these relationships and underlying variance in genes related to the processing of nutrients that may influence these relationships, or how

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Day-Tasevski, Erica. "Genetic Determinants of the Acute Effects and Withdrawal Symptoms of Caffeine." Thesis, 2010. http://hdl.handle.net/1807/24245.

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The mechanisms underlying caffeine’s acute effects and withdrawal symptoms are not entirely understood. The purpose was to determine whether these effects or symptoms co-exist in clusters, and whether they are associated with polymorphisms in β1- and β2-adrenoceptors. Subjects (n=1271) were from the Toronto Nutrigenomics and Health Study. The acute effects and withdrawal symptoms clustered into 4 and 6 factors, respectively. Subjects with the ADRβ2 Gly16Arg Gly/Arg genotype were more likely than Gly allele homozygotes to report “fatigue” withdrawal symptoms. Among >200 mg/d caffeine consumers,

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Rankin, A., B. P. Bunting, R. Poinhos, et al. "Food choice motives, attitude towards and intention to adopt personalised nutrition." 2018. http://hdl.handle.net/10454/18166.

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Yes<br>The present study explored associations between food choice motives, attitudes towards and intention to adopt personalised nutrition, to inform communication strategies based on consumer priorities and concerns. Design/Setting: A survey was administered online which included the Food Choice Questionnaire (FCQ) and items assessing attitudes towards and intention to adopt personalised nutrition. Subjects: Nationally representative samples were recruited in nine EU countries (n 9381). Results: Structural equation modelling indicated that the food choice motives ‘weight control’, ‘mood’, ‘h

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