Academic literature on the topic 'OECD 423'

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Journal articles on the topic "OECD 423"

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Rameshwar, Gothe Shivani, Pawade Uday Venkatrao, Nikam Ashwin Vithalrao, and Anjankar Meghsham Pramodrao. "OECD GUIDELINES FOR ACUTE ORAL TOXICITY STUDIES: AN OVERVIEW." International Journal of Research in Ayurveda and Pharmacy 14, no. 4 (2023): 137–40. http://dx.doi.org/10.7897/2277-4343.1404130.

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The OECD Guidelines for testing chemicals provide a unique method for assessing the potential impact of chemicals on human health and the environment. These are divided into five sections. Oral toxicity studies are mentioned in the fourth section, i.e. Health Effects. This section cites the guidelines for acute, sub-acute, sub-chronic and chronic oral toxicity studies. Acute oral toxicity refers to those adverse effects of oral administration of a single dose or multiple doses given within 24 hours. OECD guidelines for Acute oral toxicity include 420 (Fixed Dose Procedure), 423 (Acute Toxic Cl
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Ismael, Dally Laba, Fofana Yaya, Kablan Ahmont Landry Claude, and Lia Arthur José. "EVALUATION OF THE ACUTE TOXICITY OF LIANA BARK OF LANDOLPHIA OWARIENSIS P. BEAUV. (APOCYNACEAE)." International Journal of Research -GRANTHAALAYAH 8, no. 4 (2020): 167–72. http://dx.doi.org/10.29121/granthaalayah.v8.i4.2020.22.

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The objective of this study was to assess the acute toxicity of the decocted bark of the liana bark of L. owriensis P. Beauv. (Apocynaceae) in the Wistar strain rat. The study of acute toxicity was carried out according to the OECD 423 method. This study was carried out up to a limit dose of 5000 mg / kg of body weight. After administration of different oral doses, observations on behavior, respiration, skin effects, response of the sensory nervous system or the gastrointestinal effects of animals were made on the 1st, 2nd, 3rd and 14 days (OECD 423). During 14 days of observation, a decoction
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Dally, Laba Ismael, Yaya Fofana, Ahmont Landry Claude Kablan, and Arthur José Lia. "EVALUATION OF THE ACUTE TOXICITY OF LIANA BARK OF LANDOLPHIA OWARIENSIS P. BEAUV. (APOCYNACEAE)." International Journal of Research - Granthaalayah 8, no. 4 (2020): 167–72. https://doi.org/10.29121/granthaalayah.v8.i4.2020.22.

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The objective of this study was to assess the acute toxicity of the decocted bark of the liana bark of L. owriensis P. Beauv. (Apocynaceae) in the Wistar strain rat. The study of acute toxicity was carried out according to the OECD 423 method. This study was carried out up to a limit dose of 5000 mg / kg of body weight. After administration of different oral doses, observations on behavior, respiration, skin effects, response of the sensory nervous system or the gastrointestinal effects of animals were made on the 1st, 2nd, 3rd and 14 days (OECD 423). During 14 days of observation, a decoction
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Sabilla, Giriani Ayu, and Slamet Widiyanto. "Effect of SNEDDS (Self-Nanoemulsifying Drug Delivery System) kawista leaf aqueous extract (Limonia acidissima L.) on body and organ weight of Rats." Bioscience 5, no. 2 (2021): 87. http://dx.doi.org/10.24036/0202152113065-0-00.

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SNEDDS (Self-Nanoemulsifying Drug Delivery System) is a pharmacological method that can increase the bioavailability of a drug. Kawista leaf aqueous extract contains secondary metabolites in the form of flavonoids, tannins, and saponins. SNEDDS preparation of kawista leaf aqueous extract has not been reported on its effect on body weight and organs of rats. The purpose of this study was to determine the effect of SNEDDS preparation of kawista leaf aqueous extract on body weight, liver and kidney weight of Rattus norvegicus in acute toxicity testing using the OECD 423 method. Data on body weigh
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Wulan, A. Ariani Hesti, and Navtalina Putri Sekar Langit. "Uji Ketoksikan Akut Ekstrak Etanol Kangkung darat (Ipomoea reptans Poir) dan air (Ipomoea aquatic Forsk) Menggunakan Metode OECD 423." Jurnal Farmasi (Journal of Pharmacy) 10, no. 2 (2021): 20–24. http://dx.doi.org/10.37013/jf.v10i2.140.

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Kangkung memiliki dua jenis yaitu darat (Ipomoea reptans Poir) dan air (Ipomoea aquatic Forsk). Kangkung dapat digunakan untuk terapi herbal antara lain sedative, hipnotik, antidiabetes, analgetik dan ansiolitik. Obat herbal pemakaiannya cukup lama yaitu lebih dari satu minggu, maka perlu diketahui keamanannya agar tidak menimbulkan efek berbahaya yang tidak diinginkan. Tujuan dari penelitian ini adalah untuk mengetahui efek toksisitas dan menentukan nilai LD50 ekstrak etanol kangkung darat dan air menggunakan metode OECD 423. Penelitian ini menggunakan hewan uji mencit Mus musculus menggunaka
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Jonsson, Martina, Marika Jestoi, Alexis V. Nathanail, et al. "Application of OECD Guideline 423 in assessing the acute oral toxicity of moniliformin." Food and Chemical Toxicology 53 (March 2013): 27–32. http://dx.doi.org/10.1016/j.fct.2012.11.023.

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Ranawat, Sonia, Monika Gariya, Akhilesh Nautiyal, Shagil Saltanat, Tripti Padalia, and Varnika Varnika. "Evaluation of Acute Toxicity Study of Ethanolic Extract of Koelreuteria Paniculata Laxm in Albino Wistar Rats." Journal of Neonatal Surgery 14, no. 31S (2025): 600–607. https://doi.org/10.63682/jns.v14i31s.7233.

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Koelreuteria paniculata, also named as golden rain tree, indigenous to China and other Asian countries. The current study examines its potential benefits in treating a variety of pharmacological disorders, including genotoxicity, antihypertensive, antioxidant, oxidative stress, antimalarial, and antineoplastic conditions. According to OECD guideline 423, acute toxicity studies examine the efficacious of the medicinal plant (Koelreuteria paniculata) and are helpful for further in vivo and in vitro investigations of other pharmacological illnesses.
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Hamdin, Candra Dwipayana, Dheni Cahyo, and Dandiko Galanova. "KETOKSIKAN AKUT ORAL ZAT PEWARNA MAKANAN DAUN JATI (Tectona grandis L. f.) PADA TIKUS WISTAR." Pro Food 3, no. 2 (2018): 240. http://dx.doi.org/10.29303/profood.v3i2.56.

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Jati leaf becomes one of the alternative natural food coloring in some food producers. A research is needed to determine the potential of acute ketoxicity (LD50) and determine the clinical symptoms that arise also to see the groos patologi of organs resulting from single oral dosage of jati leaf extract. This research was conducted with complete randomized design using OECD 423 method. The test animal used was Wistar strain female rats. In this study, the test animals were divided into 2 groups, namely the control and treatment groups, each consisting of 3 test animals. Control group given Na
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Sobreira, Renatha Claudia Barros, Willams Alves da Silva, Tainá Maria Santos da Silva, et al. "Toxicological evaluation and safety of the ethanol extract from leaves of Piptadenia stipulaceae." Research, Society and Development 11, no. 3 (2022): e46411326815. http://dx.doi.org/10.33448/rsd-v11i3.26815.

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Piptadenia stipulacea is popularly known as “Jurema Branca” and is apply in empiric therapy as anti-inflammatory, analgesic, cells regenerator, antipyretic and astringent pectoral. The present work had as objective to carry out the toxicological analysis of the ethanol extract of the leaves of P. stipulacea. In vitro toxicity was performed according to the methodologies of osmotic fragility against sheep erythrocytes and genotoxicity by Allium cepa and in vivo toxicity according to the protocol of Organization for Economic Cooperation and Development (OECD 423). Erythrocyte osmotic fragility p
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Nguema Ongone, Terence, Latyfa El Ouasif, Mostafa El Ghoul, et al. "Synthesis of Surfactants Derived from 2-Mercaptobenzimidazole and Study of Their Acute Toxicity and Analgesic and Psychotropic Activities." Biochemistry Research International 2019 (July 30, 2019): 1–9. http://dx.doi.org/10.1155/2019/9615728.

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The aim of the present study is to synthesize cationic salts from a relatively toxic compound named 2-mercaptobenzimidazole and to evaluate some of their pharmacological properties. The acute toxicity of these salts is evaluated according to OECD 423 Guidelines at the doses of 300 and 2000 mg/kg; their peripheral analgesic effect is studied using the Koster test at the therapeutic dose of 200 mg/kg and their sedative action is evaluated using Traction, Chimney, Hole-board, and Rotarod tests at the doses of 200 and 400 mg/kg. All synthesized molecules show no acute toxicity according to OECD Co
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Dissertations / Theses on the topic "OECD 423"

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Gavrilas, M., and T. Höhne. "OECD/CSNI ISP NR. 43 Rapid Boron Dilution Transient Tests For Code Verification Post Test Calculation With CFX-4." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29679.

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The need of the experimental support for validation of the computational tools to be applied to analyze the mixing of diluted slugs has been recognized in various countries. The test series for the International Standard Problem ISP-43 provides a platform for experiences to be applied to the simulation of a well-defined test series. Test A and B of the UM2x4 loop test facility were calculated with the CFD Code CFX-4.3. Sensitivity studies were made to analyze the used turbulence model and numerical errors. The results show good agreement with the experimental data for both tests.
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Gavrilas, M., and T. Höhne. "OECD/CSNI ISP NR. 43 Rapid Boron Dilution Transient Tests For Code Verification Post Test Calculation With CFX-4." Forschungszentrum Rossendorf, 2001. https://hzdr.qucosa.de/id/qucosa%3A21794.

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The need of the experimental support for validation of the computational tools to be applied to analyze the mixing of diluted slugs has been recognized in various countries. The test series for the International Standard Problem ISP-43 provides a platform for experiences to be applied to the simulation of a well-defined test series. Test A and B of the UM2x4 loop test facility were calculated with the CFD Code CFX-4.3. Sensitivity studies were made to analyze the used turbulence model and numerical errors. The results show good agreement with the experimental data for both tests.
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Books on the topic "OECD 423"

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AUTHOR_ID, NULL. Oecd Guidelines For The Testing Of Chemicals / Section 4 : Health Effects Test No. 423: Acute Oral Toxicity - Acute Toxic Class Method. Oecd Publishing, 2002.

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OECD. Oecd Guidelines For The Testing Of Chemicals / Section 4 : Health Effects Test No. 428 : Skin Absorption: In Vitro Method. Oecd Publishing, 2004.

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Book chapters on the topic "OECD 423"

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Jenner, John. "OECD Test Guideline 428—A Method for In Vitro Percutaneous Absorption Measurement?" In Topical Drug Bioavailability, Bioequivalence, and Penetration. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1289-6_22.

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Warheit, David B. "Subchronic Inhalation Toxicity Study with a Vapor-Grown Carbon Nanofiber in Male and Female Rats (OECD 413): Does Nanofiber Exposure Have Adverse Impacts on the Cardiovascular System?" In Current Topics in Environmental Health and Preventive Medicine. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8433-2_4.

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"Developmental Neurotoxicity Study (OECD TG 426)." In OECD Series on Testing and Assessment. OECD, 2018. http://dx.doi.org/10.1787/9789264304741-27-en.

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"Subchronic Inhalation Toxicity: 90-Day Study (OECD TG 413)." In OECD Series on Testing and Assessment. OECD, 2018. http://dx.doi.org/10.1787/9789264304741-31-en.

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"Reproduction/Developmental Toxicity Screening Test (OECD TG 421) and Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD TG 422)." In OECD Series on Testing and Assessment. OECD, 2018. http://dx.doi.org/10.1787/9789264304741-25-en.

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"420, n." In Oxford English Dictionary, 3rd ed. Oxford University Press, 2023. http://dx.doi.org/10.1093/oed/1621523409.

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Rowson, Martin. "Why was Pip not invited to Joe’s wedding?" In The Literary Detective. Oxford University PressNew York, NY, 2000. http://dx.doi.org/10.1093/oso/9780192100368.003.0088.

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Abstract Malcolm Hurwitt writes to ask ‘if you are aware of the puzzle which I feel exists in Great Expectations? It may be described as “Why was not Pip invited to the Wedding?”.’ Mr Hurwitt goes on: It is, as Mr Hurwitt rightly says, odd; and it gets odder the closer one looks at the episode. After Magwitch’s euthanasia, during a ‘cold and dusty spring’ (p. 453), Pip falls into a ‘fever’–– the dreaded ‘jail-fever’, as we apprehend. (The OED defines the disease as ‘a virulent type of typhus-fever, formerly endemic in closed jails, and frequent in ships and other confined places.’) The illness
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Engelmann, Wilson, Raquel Von Hohendorff, and Daniele Weber da Silva Leal. "A green nanotechnology approach to nanowaste management: what guarantees can the OECD protocol provide?" In Nanotoxicology for Agricultural and Environmental Applications. Elsevier, 2024. http://dx.doi.org/10.1016/b978-0-443-15570-3.00007-7.

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Majstorovic Dragana and Wimmer Maria A. "A Collaborative Approach to Study Policy Modelling Research and Practice from Different Disciplines." In Innovation and the Public Sector. IOS Press, 2014. https://doi.org/10.3233/978-1-61499-429-9-153.

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An OECD study of 2009 argues that open and inclusive policy making helps to improve policy performance and to meet citizens rising expectations. An important aspect shaping the success of policy making is the use of appropriate tools and instruments to model (public) policy, i.e. to use theories, methods and tools that support the process of transforming data and information inputs into conceptual and formal models, which contribute to transparency, a better understanding of policy options (the causes and effects), and better informed decision-making to improve public performance. Accordingly,
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Papadopoulou, Paraskevi, and Miltiadis D. Lytras. "Enhancing patient welfare through responsible and AI-driven healthcare innovation: Progress made in OECD countries and the case of Greece." In Next Generation eHealth. Elsevier, 2025. http://dx.doi.org/10.1016/b978-0-443-13619-1.00003-9.

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Conference papers on the topic "OECD 423"

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Hoehne, T. "Post Test Calculation With CFX-4 of the OECD/CSNI International Standard Problem Nr.43." In 10th International Conference on Nuclear Engineering. ASMEDC, 2002. http://dx.doi.org/10.1115/icone10-22722.

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The need of experiments for validation of the computational tools to analyze the mixing of diluted slugs has been recognized in various countries. The test series performed at the UM2×4 loop test facility for the International Standard Problem ISP-43 provides a platform for experiences to be applied to the simulation of a well-defined test series. Test A was calculated with the CFD Code CFX-4.3. The results of the calculation show qualitatively good agreement with the experimental data. The structure of the flow field and the form of the propagating temperature perturbation front are well mode
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Trivić, Jelena, Marina Beljić, and Olgica Glavaški. "Sustainability of Corporate Tax Revenues in European OECD Economies Eatr Cuts and FDI Inflow." In 29th International Scientific Conference Strategic Management and Decision Support Systems in Strategic Management. University of Novi Sad, Faculty of Economics in Subotica, 2024. http://dx.doi.org/10.46541/978-86-7233-428-9_390.

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Base erosion and profit shifting (BEPS) is an endeavor to prevent increased profit shifting as a result of global tax competitiveness. However, there is still a scarcity of thorough analyses that quantify BEPS effects on the economy, tax revenues, employment, and welfare. This paper's main objective is to empirically evaluate the direct effect of EATR changes and indirect effect through FDI on the corporate tax revenue (CTR) in European OECD countries using available empirical data in the period 1998–2021. The paper analyses volume of capital/profit shifts which reflect in tax revenues loses i
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Kawaguchi, Yu, Hidenori Takahashi, Takehiro Tsuritani, and Itsuro Morita. "Performance comparison of 413-Gb/s multi-band OFDM transmission with 32/64-QAM." In 2012 Opto-Electronics and Communications Conference (OECC). IEEE, 2012. http://dx.doi.org/10.1109/oecc.2012.6276516.

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Chromec, Peter R., and Francis A. Ferraro. "Waste-to-Energy in the Context of Global Warming." In 16th Annual North American Waste-to-Energy Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/nawtec16-1954.

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In December 2007 the United Nations Framework Convention on Climate Change (UNFCCC) took place in Bali. It was based on the IPCC report no. 4 presented in Barcelona on November 2007. The messages are briefly: • Warming of the climate system is unequivocal; • Global greenhouse gas (GHG) emissions due to human activities have grown since pre-industrial times; • Continued GHG emissions at or above current rates would cause further warming and induce many changes in the global climate system during the 21st century that would very likely be larger than those observed during the 20th century; • Key
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Reports on the topic "OECD 423"

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Spindelman, Deborah. Investing in Foundational Skills First: A Case from South Korea. Research on Improving Systems of Education (RISE), 2023. http://dx.doi.org/10.35489/bsg-rise-ri_2023/052.

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In the aftermath of Japanese occupation and the Korean war, South Korea built a schooling system that today is consistently ranked among the top five countries worldwide for reading and mathematics, and in the top ten for science in the Programme for International Student Assessment (PISA) (OECD, 2014). Its consistent high ranking against wealthier countries, as well as the role of education in transforming Korea’s economy while retaining a relatively low (4.3 percent) level of spending as a portion of GDP (World Bank, 2022), has cemented its reputation among low- and middle-income countries a
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Yimam, Seid, and Yalew Mekonnen. Women in Ethiopian Tax Administration: Evidence on Representation and Performance. Institute of Development Studies, 2024. http://dx.doi.org/10.19088/ictd.2024.045.

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In the growing literature on gender and taxation in low-income countries, little attention has been given to the implications of having more women in tax administration. This is even true in high-and middle-income countries, with a recent OECD survey of 43 countries reporting that in four out of every five cases studied, no analysis had been undertaken of the gender dimensions of tax administration. The gender imbalance in revenue administrations of low-income countries remains high though it varies from country to country. It is especially pronounced in senior management positions. This study
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Vignoles, Christopher, and Anneke Jessen. CARICOM Report No. 2 (2005). Inter-American Development Bank, 2005. http://dx.doi.org/10.18235/0008587.

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Economic growth in the Caribbean Community (CARICOM) has been slow in the last two decades, averaging just 1.8 percent a year, compared to annual growth of 3.5 percent in the world economy and 4.3 percent in developing countries. Growth has varied considerably among CARICOM¿s 15 member states, but in most countries it has slowed over the years. The Organization of Eastern Caribbean States (OECS), for example, witnessed above-average growth of 5.4 percent a year in the period 1984-1994, but only 3.3 percent in 1994-1999, and only 1.2 percent in 1999-2004. Of the remaining CARICOM countries, onl
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Pessino, Carola, Nadir Altinok, and Cristian Chagalj. Allocative Efficiency of Government Spending for Growth in Latin American Countries. Inter-American Development Bank, 2022. http://dx.doi.org/10.18235/0004310.

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There is scant empirical economic research regarding the way that Latin American governments efficiently allocate their spending across different functions to achieve higher growth. While most papers restrict their analysis to the size of government, much less is known about the composition of spending and its implications for long-term growth. This paper sheds light on how allocating expenditures to investment in quality human and physical capital, and avoiding waste on inefficient expenditures, enhance growth in Latin America. This paper uses a novel dataset on physical and human capital and
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