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Journal articles on the topic 'OECD 423'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Rameshwar, Gothe Shivani, Pawade Uday Venkatrao, Nikam Ashwin Vithalrao, and Anjankar Meghsham Pramodrao. "OECD GUIDELINES FOR ACUTE ORAL TOXICITY STUDIES: AN OVERVIEW." International Journal of Research in Ayurveda and Pharmacy 14, no. 4 (2023): 137–40. http://dx.doi.org/10.7897/2277-4343.1404130.

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The OECD Guidelines for testing chemicals provide a unique method for assessing the potential impact of chemicals on human health and the environment. These are divided into five sections. Oral toxicity studies are mentioned in the fourth section, i.e. Health Effects. This section cites the guidelines for acute, sub-acute, sub-chronic and chronic oral toxicity studies. Acute oral toxicity refers to those adverse effects of oral administration of a single dose or multiple doses given within 24 hours. OECD guidelines for Acute oral toxicity include 420 (Fixed Dose Procedure), 423 (Acute Toxic Cl

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Ismael, Dally Laba, Fofana Yaya, Kablan Ahmont Landry Claude, and Lia Arthur José. "EVALUATION OF THE ACUTE TOXICITY OF LIANA BARK OF LANDOLPHIA OWARIENSIS P. BEAUV. (APOCYNACEAE)." International Journal of Research -GRANTHAALAYAH 8, no. 4 (2020): 167–72. http://dx.doi.org/10.29121/granthaalayah.v8.i4.2020.22.

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The objective of this study was to assess the acute toxicity of the decocted bark of the liana bark of L. owriensis P. Beauv. (Apocynaceae) in the Wistar strain rat. The study of acute toxicity was carried out according to the OECD 423 method. This study was carried out up to a limit dose of 5000 mg / kg of body weight. After administration of different oral doses, observations on behavior, respiration, skin effects, response of the sensory nervous system or the gastrointestinal effects of animals were made on the 1st, 2nd, 3rd and 14 days (OECD 423). During 14 days of observation, a decoction

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Dally, Laba Ismael, Yaya Fofana, Ahmont Landry Claude Kablan, and Arthur José Lia. "EVALUATION OF THE ACUTE TOXICITY OF LIANA BARK OF LANDOLPHIA OWARIENSIS P. BEAUV. (APOCYNACEAE)." International Journal of Research - Granthaalayah 8, no. 4 (2020): 167–72. https://doi.org/10.29121/granthaalayah.v8.i4.2020.22.

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The objective of this study was to assess the acute toxicity of the decocted bark of the liana bark of L. owriensis P. Beauv. (Apocynaceae) in the Wistar strain rat. The study of acute toxicity was carried out according to the OECD 423 method. This study was carried out up to a limit dose of 5000 mg / kg of body weight. After administration of different oral doses, observations on behavior, respiration, skin effects, response of the sensory nervous system or the gastrointestinal effects of animals were made on the 1st, 2nd, 3rd and 14 days (OECD 423). During 14 days of observation, a decoction

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Sabilla, Giriani Ayu, and Slamet Widiyanto. "Effect of SNEDDS (Self-Nanoemulsifying Drug Delivery System) kawista leaf aqueous extract (Limonia acidissima L.) on body and organ weight of Rats." Bioscience 5, no. 2 (2021): 87. http://dx.doi.org/10.24036/0202152113065-0-00.

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SNEDDS (Self-Nanoemulsifying Drug Delivery System) is a pharmacological method that can increase the bioavailability of a drug. Kawista leaf aqueous extract contains secondary metabolites in the form of flavonoids, tannins, and saponins. SNEDDS preparation of kawista leaf aqueous extract has not been reported on its effect on body weight and organs of rats. The purpose of this study was to determine the effect of SNEDDS preparation of kawista leaf aqueous extract on body weight, liver and kidney weight of Rattus norvegicus in acute toxicity testing using the OECD 423 method. Data on body weigh

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Wulan, A. Ariani Hesti, and Navtalina Putri Sekar Langit. "Uji Ketoksikan Akut Ekstrak Etanol Kangkung darat (Ipomoea reptans Poir) dan air (Ipomoea aquatic Forsk) Menggunakan Metode OECD 423." Jurnal Farmasi (Journal of Pharmacy) 10, no. 2 (2021): 20–24. http://dx.doi.org/10.37013/jf.v10i2.140.

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Kangkung memiliki dua jenis yaitu darat (Ipomoea reptans Poir) dan air (Ipomoea aquatic Forsk). Kangkung dapat digunakan untuk terapi herbal antara lain sedative, hipnotik, antidiabetes, analgetik dan ansiolitik. Obat herbal pemakaiannya cukup lama yaitu lebih dari satu minggu, maka perlu diketahui keamanannya agar tidak menimbulkan efek berbahaya yang tidak diinginkan. Tujuan dari penelitian ini adalah untuk mengetahui efek toksisitas dan menentukan nilai LD50 ekstrak etanol kangkung darat dan air menggunakan metode OECD 423. Penelitian ini menggunakan hewan uji mencit Mus musculus menggunaka

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6

Jonsson, Martina, Marika Jestoi, Alexis V. Nathanail, et al. "Application of OECD Guideline 423 in assessing the acute oral toxicity of moniliformin." Food and Chemical Toxicology 53 (March 2013): 27–32. http://dx.doi.org/10.1016/j.fct.2012.11.023.

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Ranawat, Sonia, Monika Gariya, Akhilesh Nautiyal, Shagil Saltanat, Tripti Padalia, and Varnika Varnika. "Evaluation of Acute Toxicity Study of Ethanolic Extract of Koelreuteria Paniculata Laxm in Albino Wistar Rats." Journal of Neonatal Surgery 14, no. 31S (2025): 600–607. https://doi.org/10.63682/jns.v14i31s.7233.

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Koelreuteria paniculata, also named as golden rain tree, indigenous to China and other Asian countries. The current study examines its potential benefits in treating a variety of pharmacological disorders, including genotoxicity, antihypertensive, antioxidant, oxidative stress, antimalarial, and antineoplastic conditions. According to OECD guideline 423, acute toxicity studies examine the efficacious of the medicinal plant (Koelreuteria paniculata) and are helpful for further in vivo and in vitro investigations of other pharmacological illnesses.

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8

Hamdin, Candra Dwipayana, Dheni Cahyo, and Dandiko Galanova. "KETOKSIKAN AKUT ORAL ZAT PEWARNA MAKANAN DAUN JATI (Tectona grandis L. f.) PADA TIKUS WISTAR." Pro Food 3, no. 2 (2018): 240. http://dx.doi.org/10.29303/profood.v3i2.56.

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Jati leaf becomes one of the alternative natural food coloring in some food producers. A research is needed to determine the potential of acute ketoxicity (LD50) and determine the clinical symptoms that arise also to see the groos patologi of organs resulting from single oral dosage of jati leaf extract. This research was conducted with complete randomized design using OECD 423 method. The test animal used was Wistar strain female rats. In this study, the test animals were divided into 2 groups, namely the control and treatment groups, each consisting of 3 test animals. Control group given Na

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Sobreira, Renatha Claudia Barros, Willams Alves da Silva, Tainá Maria Santos da Silva, et al. "Toxicological evaluation and safety of the ethanol extract from leaves of Piptadenia stipulaceae." Research, Society and Development 11, no. 3 (2022): e46411326815. http://dx.doi.org/10.33448/rsd-v11i3.26815.

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Piptadenia stipulacea is popularly known as “Jurema Branca” and is apply in empiric therapy as anti-inflammatory, analgesic, cells regenerator, antipyretic and astringent pectoral. The present work had as objective to carry out the toxicological analysis of the ethanol extract of the leaves of P. stipulacea. In vitro toxicity was performed according to the methodologies of osmotic fragility against sheep erythrocytes and genotoxicity by Allium cepa and in vivo toxicity according to the protocol of Organization for Economic Cooperation and Development (OECD 423). Erythrocyte osmotic fragility p

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Nguema Ongone, Terence, Latyfa El Ouasif, Mostafa El Ghoul, et al. "Synthesis of Surfactants Derived from 2-Mercaptobenzimidazole and Study of Their Acute Toxicity and Analgesic and Psychotropic Activities." Biochemistry Research International 2019 (July 30, 2019): 1–9. http://dx.doi.org/10.1155/2019/9615728.

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The aim of the present study is to synthesize cationic salts from a relatively toxic compound named 2-mercaptobenzimidazole and to evaluate some of their pharmacological properties. The acute toxicity of these salts is evaluated according to OECD 423 Guidelines at the doses of 300 and 2000 mg/kg; their peripheral analgesic effect is studied using the Koster test at the therapeutic dose of 200 mg/kg and their sedative action is evaluated using Traction, Chimney, Hole-board, and Rotarod tests at the doses of 200 and 400 mg/kg. All synthesized molecules show no acute toxicity according to OECD Co

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Gurung, Sushil, Mayukh Sarkar, Rohit Chettri, Sairashmi Samanta, Royan Chhetri, and Ankit Kumar Mahato. "Assessment of Acute Oral Toxicity of Sonchus wightianus DC. Methanolic Extract Using OECD 423 Guidelines." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 18 (2024): 236–41. http://dx.doi.org/10.56557/upjoz/2024/v45i184442.

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The pharmacological characteristics of Sonchus wightianus DC, a perennial herb belonging to the Asteraceae family, have been reported in many publications. This plant offers many benefits (antimicrobial, antioxidant), but data on its toxic potential are limited. It is necessary to confirm the safety of plants and pharmaceuticals prior to their use as medicines. Thus, this study's objective was to assess the acute oral toxicity of a methanolic extract obtained from Sonchus wightianus in a rat model using fixed dosage tests, with an upper limit administration of two thousand milligrams per kilog

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12

Krishnamurthy, Praveen Thaggikuppe, Merina Benny, Benny Antony, Binu T. Kuruvilla, and Nishant Kumar Gupta. "Safety Evaluation of Amaranth Extract by Acute, Sub-Chronic and Chronic Exposure in Rats." Biomedical and Pharmacology Journal 16, no. 4 (2023): 1973–87. http://dx.doi.org/10.13005/bpj/2774.

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Amaranth is one of the popularly grown leafy vegetables in tropical regions globally and contains a large amount of nitrate. The present study's objective was evaluation of acute and repeated dose toxicity of amaranth extract as per the OECD guidelines. The acute oral toxicity was conducted in 6 female rats (150-170 g; 8-10 Weeks old) as per OECD 423 guidelines. The amaranth extract had no adverse/toxic effects and no mortality was noted at the dose of 2000mg/kg. The oral LD50, therefore, was considered greater than 2000mg/kg. The sub-chronic (28-day repeated dose) toxicity was studied in 40 r

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Dueñas Rivadeneira, Alex, Remigio Cortés Rodríguez, Osmany Marrero Chang, Jorge Pérez Donato, and Ervelio Olazábal Manso. "Toxicidad aguda del extracto hidroalcohólico de la planta Chuquiraga jussieui, administrado vía oral en ratas." La Técnica: Revista de las Agrociencias. ISSN 2477-8982, no. 10 (June 3, 2013): 12. http://dx.doi.org/10.33936/la_tecnica.v0i10.559.

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Se evaluó la toxicidad por administración oral a dosis única de un extracto hidroalcohólico concentrado de la planta Chuquiraga jussieui. El estudio se realizó en ratas de la línea Sprague Dawley (Cenp:SD) y se aplicó el método de dosis fija a dosis límite OECD 423. El extracto se administró por vía oral en dosis única de 2000 mg/kg en un volumen de 20 mL/kg de peso corporal. No se observaron signos de toxicidad durante los 14 días post administración 5 en los animales en estudio. Hubo ganancia de peso en todos los animales del grupo. No se apreciaron lesiones anatomopatológicas macroscópicas

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Bedi, Onkar, and Pawan Krishan. "Investigations on acute oral toxicity studies of purpurin by application of OECD guideline 423 in rodents." Naunyn-Schmiedeberg's Archives of Pharmacology 393, no. 4 (2019): 565–71. http://dx.doi.org/10.1007/s00210-019-01742-y.

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Narayanan, Siju Ellickal, Mohamed A. Abdelgawad, Yusuf S. Althobaiti, et al. "Effect of Hydroaloholic Extract of Rotula Aquatica Lour on Gentamicin-Induced Nephrotoxicity in Wistar Albino Rats: An In Vitro and In Vivo Approach." Journal of Biomedical Nanotechnology 18, no. 3 (2022): 884–90. http://dx.doi.org/10.1166/jbn.2022.3301.

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One-third of the world population suffer from kidney complications such as acute and chronic renal failure, renal calculi, kidney stones, Fanconi’s syndrome and urethritis which doesn’t have a proper effective treatment regimen. The current study explores the nephroprotective effect of herbal drug Rotula Aquatica by both In Vitro and In Vivo methods. MTT assay was applied In Vitro to evaluate the nephroprotective effect of R. aquatica leaves extract on HEK 293 cell line. The acute toxicity of the extract was evaluated as per the limit test under the protocol of OECD 423 at a concentration of 2

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16

Yaya, Soro Tianga, Mian Jean Claude, Coulibaly Sirabana, and Traoré Flavien. "Antipyretic Activity of Aqueous Extract of Daniellia oliveri Leaves (Rolfe, Hutch Et Dalz) (Fabaceae)." Scholars Academic Journal of Pharmacy 11, no. 11 (2022): 193–99. http://dx.doi.org/10.36347/sajp.2022.v11i11.002.

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The pharmacological study of the aqueous extract of Daniellia oliveri (Fabaceae) leaves revealed antipyretic properties .This dose-dependent reduction in brewer's yeast-induced hyperthermia in rats is similar to that of lysine acetylsalicylate. Qualitative phytochemical screening shows that the aqueous leaf extract of Daniellia oliveri contains polyphenols, flavonoids, saponosides, quinone substances, alkaloids, catechic and gallic tannins, sterols, polyterpenes and cardiodic heterosides. The oral LD50 of the aqueous extract of Daniellia oliveri leaves conducted according to OECD guideline 423

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Thakurdesai, Prasad Arvind, Pallavi Onkar Deshpande, and Sunil Bhaskaran. "Preclinical Toxicity Assessment of Polyphenols-Based Standardized Extract of Cinnamomum zeylanicum Bark." Current Research in Nutrition and Food Science Journal 12, no. 2 (2024): 579–90. http://dx.doi.org/10.12944/crnfsj.12.2.8.

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Background: Cinnamon (Cinnamomum zeylanicum) bark is used as a spice in culinary practices and has been documented for health and medicinal benefits. Polyphenol (PP) is the major bioactive constituent of cinnamon bark. However, acceptable and safe dose levels and toxicity information of oral exposure to PP-based standardized cinnamon bark extract (PP-CZ) are crucial for safe human consumption. Objective: To evaluate PP-CZ for acute oral, subchronic oral toxicities in vivo, mutagenicity in vitro and genotoxic potential in vitro. Method:. The effects of oral treatment with single- and 90-days re

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Murwanti, Retno, A. Nurrochmad, Andayana P. Gani, et al. "Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague–Dawley Rats." Journal of Toxicology 2023 (January 3, 2023): 1–11. http://dx.doi.org/10.1155/2023/7511397.

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Background. The product combination of Piper crocatum Ruiz. and Pav., Phyllanthus niruri Linn., and Typhonium flagelliforme (Lodd.) BL ethanolic extract (SKM) exerts immunomodulatory activity. However, the toxicity profile of the combination has never been investigated. Objective. This study aimed to establish the acute toxicity profile of the SKM product on Sprague–Dawley (SD) rats and its subchronic toxicity profile on female SD rats. Method. The acute and subchronic toxicity tests were conducted in accordance with OECD 423 and OECD 408, respectively. Result. The SKM product was safe up to 5

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Razali, Faizan Naeem, Nur Syahirah Izzati Rani, Muhammad Imran Kamil Mazian, Ahmad Naeem Mohd Nafi, and Siti Hajar Musa. "Preclinical Acute Toxicity Assessment of a Crude Polysaccharide Isolated from the Stem of Solanum Nigrum: A Preliminary Analysis." Biomedical and Pharmacology Journal 14, no. 4 (2021): 2131–39. http://dx.doi.org/10.13005/bpj/2310.

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The polysaccharide isolated from Solanum nigrum was proven to possess an immunomodulatory effect and able to suppress the progression of tumor cells by proxy. However, data on the toxicity profile is still limited. The present preclinical study was conducted to investigate the toxicity potential of the crude polysaccharide sample. The acute toxicity experimental design was adapted from OECD 423 guideline. Nine female BALB/c mice were randomly divided into 3 groups, 3 mice per group (n=3). Mice in group A (first-step treatment) were orally administered with a single treatment of crude polysacch

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Gaidhani, Sudesh N., S. Viswanth Reddy, Srikanth Ala, et al. "Acute and repeated dose oral toxicity study of AYUSH SG-5 in Sprague Dawley rats." International Journal of Ayurveda Research 6, no. 1 (2025): 25–31. https://doi.org/10.4103/ijar.ijar_97_24.

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Background: AYUSH SG-5 is a coded polyherbal formulation developed by the Central Council for Research in Ayurvedic Sciences for the treatment of arthritis. The safety evaluation of the test drug has not been established yet. Aim: The aim of this study was to evaluate the acute and repeated dose toxicity by following the Organization for Economic Cooperation and Development (OECD) 423 and 408 guidelines. Materials and Methods: Acute oral toxicity was performed in Sprague Dawley rats with a limit test dose of 2000 mg/kg as per OECD guideline No. 423 and changes in feed intake, body weight, and

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Joshi, Tanuj, and Vijay Juyal. "Evaluation of Acute Toxicity of Some Medicinal Plants and their Combination in Albino Mice." Defence Life Science Journal 6, no. 2 (2021): 166–70. http://dx.doi.org/10.14429/dlsj.6.16578.

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Medicinal plants find use across different cultures in the world. People have derived numerous benefits by using various plants for centuries. Herbal drugs are supposed to be safe, but there are chances these might cause toxicity and other complications. Thus toxicity studies are essential for a medicinal plant before being used in humans. The present research revolves around studying the acute toxicity of Ocimum kilimandscharicum, Thymus serpyllum, Spilanthes acmella and their combination in equal ratio (COMB). For preparing the combination of extracts, the ethanolic extracts of the three pla

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Hajare, Sunil, Ranjit Suresh Ingole, Mahesh Kumar Vitthal Ingawale, et al. "Evaluation of acute oral toxicity of a herbal semen quality enhancer." Journal of Phytopharmacology 10, no. 6 (2021): 496–99. http://dx.doi.org/10.31254/phyto.2021.10611.

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The objective of this study was to assess the acute oral toxicity of AV/SGB/27 (M/s Ayurvet Limited) in accordance with OECD-423 guideline. AV/SGB/27 is a herbal formulation for enhancing semen quality of livestock. Nine healthy and adult nulliparous nonpregnant Swiss albino female mice, weighing 24-28 g, were used in this study. After being given test material orally, the mice were examined for toxic effects and mortality. Changes in body weights, symptoms of toxicity, histological appearances of liver, kidney, and lungs, and biochemical parameters were used to assess the toxicity. No toxic e

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Patil, Subhash, and Rakesh Kumar Jat. "Acute Toxicity Study of Seed-Based Polymers in Wistar Rats: Evaluation of Safety Profile." International Journal of Drug Regulatory Affairs 13, no. 2 (2025): 52–59. https://doi.org/10.22270/ijdra.v13i2.757.

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Seed-based polymers are gaining attention in pharmaceutical formulations due to their biodegradable and biocompatible nature. The present study evaluates the acute toxicity profile of three different seed-based polymers in Wistar rats. Single oral doses (2000 mg/kg) were administered as per OECD guideline 423. The study recorded mortality, body weight changes, behavioral alterations, and biochemical parameters to assess any potential toxic effects. No mortality or significant behavioral changes were observed, confirming the safety of these polymers. Histopathological examination revealed no si

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Saxena, Gaurav, Abhilasha Mittal, and Abdul Wadood Siddiqui. "Acute Toxicity Studies and In-vitro Antioxidant Potential of Solanum indicum." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 736–39. http://dx.doi.org/10.22270/jddt.v9i3-s.2969.

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Solanum indicum (Solanaceae) is traditionally used treatment of cough, asthma, sexual disorders and diarrhoea. Efficacy of traditional medicine was determined using the in-vitro antioxidant activity of the plant extract. Toxicological codicil of the drug was performed following OECD guidelines 423 with slight modifications. Solanum indicum extract administered to the rats by oral gavage at 500, 1000, 1500 & 2000 mg/kg body weight daily up to 28 days to male and female Sprague Dawley rats. Oral toxicity studies substantiate, no treatment-related death or toxic indicia were observed. It reve

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Yanru, Sun, Shen Zhenhuang, Jia Zhe, and Miao Xiaoqing. "Safety Evaluation of an Apitherapy Formulation, Bao-Yuan-Ling: Acute and Sub-acute Oral Toxicity in Wistar Rats." Current Topics in Nutraceutical Research 17, no. 1 (2017): 85–92. http://dx.doi.org/10.37290/ctnr2641-452x.17:85-92.

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Bao-Yuan-Ling (BYL) is an apitherapy formulation which is composed of royal jelly, propolis and bee venom. Cardioprotective effects of BYL has been demonstrated, while the toxicity of BYL was not clear. In this study, acute and sub-acute toxicity test of BYL was processed following Organization for Economic Co-operation and Development (OECD) 423 and OECD 407, respectively, in Wistar rats. In acute toxicity test, rats were orally treated with BYL at the single dose of 2000 mg/kg and 5000 mg/kg. No death occurred in the acute toxicity test for 7 days, which indicated the lethal dose 50% value e

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Ortiz-Andrade, Rolffy, Jesús Alfredo Araujo-León, Amanda Sánchez-Recillas, et al. "Toxicological Screening of Four Bioactive Citroflavonoids: In Vitro, In Vivo, and In Silico Approaches." Molecules 25, no. 24 (2020): 5959. http://dx.doi.org/10.3390/molecules25245959.

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Many studies describe different pharmacological effects of flavonoids on experimental animals and humans. Nevertheless, few ones are confirming the safety of these compounds for therapeutic purposes. This study aimed to investigate the preclinical safety of naringenin, naringin, hesperidin, and quercetin by in vivo, in vitro, and in silico approaches. For this, an MTT-based cytotoxicity assay in VERO and MDCK cell lines was performed. In addition, acute toxicity was evaluated on Wistar rats by OECD Guidelines for the Testing of Chemicals (Test No. 423: Acute Oral Toxicity-Class Method). Furthe

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A, Satheesh Kumar, Manikgantan E, and Ravichandran M. "Safety Evaluation of Novel Siddha Herbal Formulation Maramanjal Chooranam: Acute and Subacute Toxicity Evaluations in Sprague Dawley Rats." Indian Journal of Science and Technology 18, no. 9 (2025): 745–54. https://doi.org/10.17485/IJST/v18i9.3840.

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<strong>Background:</strong> Maramanjal Chooranam (MMC) is a novel siddha herbal medicine believed to offer therapeutic benefits such as anti-inflammatory and hepatoprotective effects. Evaluating the toxicological effects associated with herbal medicine is a crucial public health concern that must be addressed to better establish its clinical efficacy. <strong>Aim and Objective:</strong> Aim of the present study is to evaluate the acute and sub acute toxicity of MMC in Sprague Dawley rats, through biochemical, hematological, and histopathological analyses. Materials & Method

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Sousa, Eliane Leite de, Ana Ruth Sampaio Grangeiro, Isla Vanessa Gomes Alves Bastos, et al. "Antitumor activity of leaves of Himatanthus drasticus (Mart.) Plumel-Apocynaceae (janaguba) in the treatment of Sarcoma 180 tumor." Brazilian Journal of Pharmaceutical Sciences 46, no. 2 (2010): 199–203. http://dx.doi.org/10.1590/s1984-82502010000200005.

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Himatanthus drasticus, also known as janaguba, is used popularly in Brazil's Northeastern region in the treatment of cancer. However, no scientific reports are available. The present study is the first investigation on the antitumor activity of crude methanolic extract from Himatanthus drasticus leaves against Sarcoma 180 tumor and on its side effects including acute oral toxicity. The OECD 423 methodology was used to study acute oral toxicity, and the STOCK methodology to assess antitumor activity. The crude extract showed low toxicity at the tested doses (50, 300 and 2000 mg/kg) administered

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Hajare, Sunil, Mistu Tripura, Shubham Belkhede, Ranjit Ingole, Bhupesh Kamdi, and Shreya Gupta. "Evaluation of Acute Oral Toxicity of Ayucee Premix Polyherbal Poultry Formulation Containing Natural Vitamin C and Bioflavonoids." Journal of Advances in Biology & Biotechnology 27, no. 2 (2024): 211–15. http://dx.doi.org/10.9734/jabb/2024/v27i2711.

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A study was conducted for the assessment of acute oral toxicity and safety analysis of Ayucee Premix (M/s Ayurvet Limited Baddi, India) according to OECD-423 guidelines. Six young adult Wistar rats, weighing 126-136 gm, were used for the study. After Oral administration of test compound the animals were observed for manifestation of toxic effect and death. Each animal served as its own control. Evaluation of safety analysis and toxicity was performed on the basis of presence of mortality or any clinical signs like lethargy, tremor, abdominal breathing and piloerection. Results showed no toxic

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Umamaheswar Rao, O., and M. Chinna Eswaraiah. "Single dose oral toxicity study of ethanolic extract from inflorescence of Casuarina equisetifolia in Wistar rats." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 44–47. http://dx.doi.org/10.22270/jddt.v8i6-s.2075.

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The purpose of the study was to evaluate the single dose oral toxicity of the ethanolic extract from inflorescence of Casuarina equisetifolia, Family: Casuarinaceae in female Wistar Rats. The acute toxicity study was carried out based on Organization for Economic Co-operation and Development (OECD) Test Guideline 423. However, this plant safety evaluation data was not available so, selected the starting dose from 300 mg/kg body weight. The animals were orally administered a single dose of 300 mg/kg body weight and followed by 2000 mg/kg body weight in next step. Signs of toxicity and mortality

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Adigwe, Obi Peter, Lucy Binda John-Africa, Bulus Adzu, Gloria Ahunna Ajoku, Abubakar Mustapha Danraka, and Jemilat Aliyu Ibrahim. "Evaluation of the toxic effects of the aqueous extract of Niprineem tea in mice and rats." International Journal of Biological and Chemical Sciences 15, no. 5 (2022): 1979–90. http://dx.doi.org/10.4314/ijbcs.v15i5.23.

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Azadirachta indica is an important plant in traditional complementary and alternative medicine with decoctions (tea) being a common mode of administration. Herbal teas are frequently self-administered thus the need to prepare a standardized dosage form for the administration of such decoctions. The leaf of Azadirachta indica was formulated for administration as tea; thus, this study was designed to determine the safety profile of Niprineem tea. Oral acute and sub-chronic toxicity studies of the aqueous extract of Niprineem tea (NTE) were evaluated. The OECD (No 423) limit test was followed to

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Mian, Jean Claude, Tianga Yaya Soro, Sirabana Coulibaly, and Flavien Traoré. "Analgesic Activity of Aqueous Extract of Daniellia Oliveri Leaves (Rolfe, Hutch Et Dalz) (Fabaceae)." American Journal Of Pharmacy And Health Research 9, no. 7 (2022): 1–15. https://doi.org/10.5281/zenodo.7098938.

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ABSTRACT The pharmacological study of the aqueous extract of <em>Daniellia</em> <em>oliveri</em> (Fabaceae) leaves revealed analgesic properties similar to those of Aceclofenac. The results obtained indicate that the aqueous extract of <em>Daniellia</em> <em>oliveri</em> leaves causes a decrease in the number of abdominal cramps in the writhing test and pain inhibition in the second phase of the formaldehyde test. However, it should be noted that the aqueous extract of <em>Daniellia</em> <em>oliveri</em> leaves has no inhibitory effect on pain in the tail-flick test and the first phase of the

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Pavani C H. "Investigation of antiulcer activity of Pergularia extensa Linn." International Journal of Research in Phytochemistry and Pharmacology 9, no. 2 (2020): 23–26. http://dx.doi.org/10.26452/ijrpp.v9i2.1198.

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This study was based on determination of the antiulcer activity from methanol extract was prepared by using barks of pergularia extensa linn.. Priliminary investigations showed presence of saponins, terpenes, cardiac glycosides, alkaloids and sterols. Based on OECD-423 Guidelines, the pharmacology and acute oral toxicity studies were conducted by using methanolic extract. Ulcer development was prevented by Tannins because of their vasoconstriction effects and due to protein precipitation. Similarly, the Methanolic extract of Pergularia extensa Linn shows triterpenoids and saponins. The phytoco

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Llahuilla, José A., Pablo E. Bonilla, Jorge L. Arroyo, Silvia Suárez, and Francisco Armijo. "EFECTO ANTIOXIDANTE Y TOXICIDAD AGUDA ORAL DE LAS AGUAS TERMALES DE SAN ANTONIO DE PUTINA-PUNO." Ciencia e Investigación 17, no. 2 (2014): 64–68. http://dx.doi.org/10.15381/ci.v17i2.13591.

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Se estudiaron el efecto antioxidante y la toxicidad de las aguas termales de San Antonio de Putina-Puno, por los métodos de antiperoxidación lipídica, malondialdehido (expresado como TBARS), la toxicidad aguda oral in vivo a dosis fijas según la OECD 423 y la composición fisicoquímica por espectrometría de pesos con fuente de plasma de acoplamiento inductivo (ICP-MS). El efecto antioxidante presentó diferencia significativa entre el grupo control (0,0527 ŋm) y el grupo estudio (0,0390 ŋm) malondialdehido (p<0,05) y en la toxicidad aguda oral in vivo a dosis fijas, después del tratamiento, n

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Putri, Cynthia Astiti, Farida Hayati, Lutfi Chabib, and Muhammad Iqbal Pangestu. "Acute Toxicity of Self-Nanoemulsifying Drug Delivery System of Ipomoea reptans Poir Leaves Extract on Female Wistar Rats." Borneo Journal of Pharmacy 6, no. 1 (2023): 1–7. http://dx.doi.org/10.33084/bjop.v6i1.2099.

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Ipomoea reptans Poir has many health benefits, such as decreasing blood glucose and as an antioxidant. Self-nano emulsifying drug delivery systems (SNEDDS) are an innovation in pharmaceutical technology that minimizes drug molecules and maximizes surface area, thus increasing drug absorption. This study aimed to investigate SNEDDS of I. reptans acute toxicity in female Wistar rats. An acute toxicity test was done using a limit test of OECD 423. Female Wistar rats were divided into control and treatment groups, with three animals for each group being used per step. No animals died after they we

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Saxena, Gaurav, Abhilasha Mittal, and Abdul Wadood Siddiqui. "Evaluation of acute and subchronic toxicity of dragon blood resin extract." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 362–66. http://dx.doi.org/10.22270/jddt.v9i2.2435.

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Draceana cinnabari (Dracaenaceae) is traditionally used in the treatment of wounds, leucorrhea, fractures, and diarrhoea. Herein, we performed a pre-clinical safety evaluation of extract of Draceana cinnabari resin on Spradgue Dawley rats. Toxicological codicil of the extract was carried out following OECD guidelines 423 and 407, with minor changes. DC resin methanol extract administered to the rats by oral gavage at 50, 500, 1500, and 2500 mg/kg body weight daily up to 28 days to male and female rats. Herbal extract could most likely be very much endured up to the dose 2000 mg/kg body weight

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Mukhammadiev, Rish S., Rin S. Mukhammadiev, I. V. Rud, et al. "Parameters of acute toxicity and sensitizing properties of a microbiological preparation based on L. acidophilus IV138 and B. subtilis GA24 strains." IOP Conference Series: Earth and Environmental Science 1096, no. 1 (2022): 012027. http://dx.doi.org/10.1088/1755-1315/1096/1/012027.

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Abstract This article presents the results of a study of the parameters of acute toxicity and sensitizing properties of a microbiological additive based on probiotic strains L. acidophilus IV138 and B. subtilis GA24 on White Wistar rats and White Giant rabbits. The acute toxicity class of the prototype feed additive was established in accordance with the fundamental document OECD Test № 423 “Acute Oral Toxicity - Acute Toxic Class Method” (2001). The evaluation of the irritating properties of the microbiological preparation was carried out by the method of skin applications and using the test

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B.K., Athira, and Minil M. "EVALUATION OF ANTIDIABETIC ACTIVITY OF BILE FROM GALLUS GALLUSDOMESTICUS." International Journal of Advanced Research 12, no. 07 (2024): 1321–43. http://dx.doi.org/10.21474/ijar01/19178.

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Diabetes mellitus is a chronic condition characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The current study aimed at evaluating the antidiabetic activity of bile from Gallus gallusdomesticus. The zoochemical analysis revealed the presence of steroids. The invitro antioxidant activity of the HMEB and in vitroantiinflammatory activity of HMEB was evaluated. The invitroantidiabetic activity was investigated by Î±-Amylase inhibition assay, and glucose uptake assay. The gene expression study was carried out for GLUT-4 and PPAR-ê© was compared wit

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Modupe Iretiola Builders, Glory Zidyep Michael, Samuel Otokpa Ede, Simeon Oyepata Joseph, and Peter Uduak Ise. "Evaluation of acute and subacute toxicity of the extract of allium cepa peels in Wistar rats." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 1173–80. http://dx.doi.org/10.30574/wjarr.2023.18.2.0839.

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Allium cepa is a popular recipe used traditionally to treat diabetes, cardiovascular diseases, cancer, wounds and infections. The acute and sub-acute oral toxicity profile of the aqueous extract of Allium cepa peels were evaluated in wistar albino rats in order to determine its safety for use in traditional medicine. The median lethal dose (LD 50) body weights and food intake were determined. The acute oral toxicity of the peel extract was carried out in accordance with OECD guideline 423. In addition to this, the haematological parameters and biochemical parameters were also evaluated. The me

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Kadam, Asha Bhausaheb. "Evaluation of Synergistic Formulation Extract of Traditional Contraceptive Plants for Acute Oral Toxicity." Advances in Clinical Toxicology 8, no. 4 (2023): 1–8. http://dx.doi.org/10.23880/act-16000284.

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In folk medicine, certain plants are used to prevent pregnancy. The purpose of the study was to evaluate the synergistic formulation of conventional contraceptive herb’s acute toxicity. Acute toxicity refers to a negative change that happens right away after exposure to a drug. Using OECD-423 recommendations, the acute toxicity of crude oil and its aqueous extract was assessed after oral administration to female mice. 2000mg/kg of a high extract was provided as a single dosage, and the effects on mortality, behavioural pattern, and spontaneous movement (Locomotor activity) of the body were ass

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Dossouvi, Komla, Kossi Dossouvi, Akueba Dossouvi, and Kokou Dossouvi. "In vivo acute and subacute toxicity assessments of Viroscope®, a polyherbal ethanolic formulation produced in Lomé, Togo." JOURNAL OF RESEARCH IN TRADITIONAL MEDICINE 10, no. 1 (2024): 1. http://dx.doi.org/10.5455/jrtm.2024-190054.

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Background: Phyto-medicines have been used to treat various diseases since ancient times. However, several studies have reported the toxicity of some medicinal plant preparations. Objective: This study aimed to evaluate the in vivo acute and subacute toxicity of an ethanolic extract of medicinal plants, “VIROSCOPE®”, produced by Viroscope SARL-U in Lomé, Togo. Materials and Methods: Acute toxicity assessment was conducted according to the “OECD guideline 423 for the assessment of the acute toxicity of chemicals.” This study focused on the ready-to-use VIROSCOPE® and on the concentrated extract

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OUEDRAOGO, Geoffroy Gueswindé, Bonewendé Mohamed BELEMLILGA, Tombègou KOUGUILIMA, et al. "Toxicity assessment of a phytomedicine based on an almond extract from the fruit of Balanites aegyptiaca (L.) DELILE (Zygophyllaceae) intended for helminthiases care in Burkina Faso." Journal of Drug Delivery and Therapeutics 15, no. 1 (2025): 93–100. https://doi.org/10.22270/jddt.v15i1.6939.

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Balanites aegyptiaca (L.) Delile (Zygophyllaceae) is a medicinal plant used in traditional medicine in Burkina Faso to treat helminthiasis. Using an ethnopharmacological approach, the "Institut de Recherche en Sciences de la Santé (IRSS)" has developed a phytomedicine based on an almond extract from the fruit of this plant for the treatment of helminthiasis. This study aimed to assess the acute and subacute oral toxicity and in vivo mutagenicity of phytomedicine. The acute toxicity study was carried out following OECD guideline 423 by administering a single dose of 2000 mg/kg body weight (bw)

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Hajare, Sunil, Ranjit Suresh Ingole, Maheshkumar Vitthal Ingawale, Vivek Borekar, Ravikanth Kotagiri, and Bhaskar Ganguly. "Evaluation of acute oral toxicity of herbal rumenotoric and stomachic." Journal of Phytopharmacology 10, no. 5 (2021): 282–85. http://dx.doi.org/10.31254/phyto.2021.10501.

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Maintaining optimum digestive functions is crucial for achieving health and profitability in livestock enterprises. However, the efficiency of these functions is upset by common problems such as indigestion, anorexia, flatulence, ruminal stasis and impaction. Pachoplus™ (M/s Ayurvet Limited, India) is a polyherbal rumenotoric, carminative and stomachic that helps to achieve and restore optimum digestive functions in livestock. A study was undertaken to evaluate the potential of Pachoplus™ to elicit acute oral toxicity as per OECD 423 guidelines. Nine non-pregnant, nulliparous, adult female Swi

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Babre, Nilesh P., Subal Debnath, Manjunath S Y, Malla Reddy V, Murlidharan Panda, and Manoj G. "Antidiabetic Effect of Hydroalcoholic Extract of Barringtonia acutangula Linn. Root on Streptozotocin-induced Diabetic Rats." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 3 (2010): 1158–64. http://dx.doi.org/10.37285/ijpsn.2010.3.3.14.

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Phytochemicals such as alkaloids, glycosides, phenols, tannins, carbohydrates and saponins have been known to possess antidiabetic activity. The crude aqueous ethanolic extract from roots of Barringtonia acutangula Linn (EBA) were prepared, subjected to preliminary photochemical analyses to know the presence of alkaloids, flavonoids, tannins and saponins, which are proved to act as potent antioxidants indicating the possibility of the antidiabetic nature. The crude aqueous extract at a dose of 2000 mg/kg bw/p.o were used for studying acute oral toxicity as per OECD 423 guideline. Neither letha

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Wresdiyati, Tutik, Stephany Stephany, Ekowati Handharyani, Siti Sa’diah, and Made Astawan. "Acute Toxicity Test of Pigeon Pea Leaves Extract (Cajanus cajan) in Rats." E3S Web of Conferences 151 (2020): 01043. http://dx.doi.org/10.1051/e3sconf/202015101043.

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Acute toxicity test was conducted to evaluate the safety level of pigeon pea (Cajanus cajan) leaves extract, using the Organisation for Economic Co-operation and Development (OECD 423) guideline method. The pigeon pea leaves were extracted using 96%ethanol as a solvent. A total of 9 male rats were used divided into 3 groups: 1 control group and 2 treatment groups. The rat in control group (group 1) received a single dose of distilled water while the rat in groups 2 and 3 received a single dose of pigeon pea leaves extract at doses of 300 mg/kg BW and 2000 mg/kg BW, respectively. The aquadest a

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Sharma, Gaurav, Tejpal Yadav, Sanjeev Sharma, and Vikram Kumar. "Polyherbal Formulation Development for Parkinson's Disease: Comprehensive Quality Control and Toxicological Evaluation." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1055–58. https://doi.org/10.25258/ijddt.14.4.19.

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Background and objectives: In this study, extracts from eight herbal medicines Withania somnifera, Nardostachys jatamansi, Convolvulus pluricaulis, Mucuna pruriens, Centella asiatica, Bacopa monnieri, Tinospora cordifolia, and Ginkgo biloba were combined to create a potential medication. Methods: Quality Control study had been done according guideline or procedure drafted by CCRAS, Ministry of AYUSH, Govt. of India, Oral Acute and Repeated Dose 28-day Toxicity Study had been done according to OECD 423 and 407 guidelines. Results: The polyherbal formulation's physiochemical characteristics, phy

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Nguema Ongone, Terence, Redouane Achour, Mostafa El Ghoul, et al. "Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One." Advances in Pharmacological Sciences 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/6042602.

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The objective of our work is to make a pharmacological study of molecules derived from 4-phenyl-1,5-benzodiazepin-2-one carrying long chains so that they have a structure similar to surfactants, with the benzodiazepine as a hydrophilic head and a carbon chain as a hydrophobic tail. First, we studied the acute toxicity of the above mentioned 4-phenyl-1,5-benzodiazepin-2-one derivatives. This study was conducted according to OECD 423 guidelines in female mice and revealed that these compounds are nontoxic. We then assessed the psychotropic effects of our products on the central nervous system (C

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Kumar CN, Santhosh, Shridhar N B, Satyanarayana M L, and Ansar Kamran C. "Toxicity studies of Sapindus laurifolius methanolic leaf extract in Wistar rats." Journal of Laboratory Animal Science 2, no. 1 (2024): 32–37. https://doi.org/10.48165/jlas.2019.2.1.6.

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Studies were aimed to evaluate the phytochemical composition of the Sapindus laurifolius leaves and toxicological effect of the Sapindus laurifolius leaf extract using Wistar albino rats as a model animal. The phytochemical analysis was performed using High Performance Thin Layer Chromatography (HPTLC). In toxicity studies, the acute oral toxicity study was conducted as per the guidelines of Organization for Economic Co-operation and Development (OECD 423 Acute Toxic Class Method) for testing of chemicals. In repeated dose 28-day oral toxicity study (OECD 407), leaf extract administered at the

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Niyomchan, Apichaya, Wasapon Chatgat, Bodin Chatawatee, et al. "Safety Evaluation of the Polyherbal Formulation NawaTab: Acute and Subacute Oral Toxicity Studies in Rats." Evidence-Based Complementary and Alternative Medicine 2023 (July 24, 2023): 1–11. http://dx.doi.org/10.1155/2023/9413458.

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NawaTab is a tablet formulation developed from the Nawametho polyherbal formula used in Surat Thani province, Southern Thailand, for the treatment of hyperlipidemia. This study aims at evaluating the acute and subacute toxicity of NawaTab in rats. In the acute toxicity study, NawaTab was evaluated in female rats following the OECD Guideline No. 423. In the subacute toxicity study, NawaTab was tested in both male and female rats following the OECD Guideline No. 407. In the acute toxicity study, no lethal effects or toxic signs were observed during the duration of the study. In the subacute toxi

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Dossou-Agoin, Gérard Bessan, Maxime Machioud Sangaré-Oumar, Téniola Isabelle Sacramento, et al. "Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats." Journal of Toxicology 2023 (July 21, 2023): 1–10. http://dx.doi.org/10.1155/2023/2962905.

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Background. Pedalium murex (P. murex) is used in folk medicine for treatment of male infertility. However, scientific data on its safety are limited. Objective. This study was carried out to assess the acute and repeated dose 28-day oral toxicity of the aqueous extracts from P. murex leafy stem and fruit in Wistar rats. Methods. The acute toxicity test was performed according to the line 423 of the Organization for Economic Cooperation and Development (OECD) guidelines. The rats were randomly divided into three groups (n = 3). The control group received distilled water, while the experimental

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