Relevant bibliographies by topics / Off-target assessment

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Off-target assessment'

Author: Grafiati
Published: 11 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Off-target assessment"

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Soltani, Nader, Maxwel C. Oliveira, Guilherme S. Alves, et al. "Off-target movement assessment of dicamba in North America." Weed Technology 34, no. 3 (2020): 318–30. http://dx.doi.org/10.1017/wet.2020.17.

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AbstractSix experiments were conducted in 2018 on field sites located in Arkansas, Indiana, Michigan, Nebraska, Ontario, and Wisconsin to evaluate the off-target movement (OTM) of dicamba under field-scale conditions. The highest estimated percentages of dicamba injury in non–dicamba-resistant (DR) soybean were 55%, 44%, 39%, 67%, 15%, and 44% injury for noncovered areas and 55%, 5%, 13%, 42%, 0%, and 41% injury for covered areas during dicamba application in Arkansas, Indiana, Michigan, Nebraska, Ontario, and Wisconsin, respectively. The level of injury generally decreased as the downwind dis
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Wang, Dan, Cuili Niu, Jingxin Han, Dejun Ma, and Zhen Xi. "Target DNA mutagenesis-based fluorescence assessment of off-target activity of the CRISPR-Cas9 system." RSC Advances 9, no. 16 (2019): 9067–74. http://dx.doi.org/10.1039/c8ra10017a.

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Chaudhari, Hemangi G., Jon Penterman, Holly J. Whitton, et al. "Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods." CRISPR Journal 3, no. 6 (2020): 440–53. http://dx.doi.org/10.1089/crispr.2020.0053.

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Ratcliffe, Laura, Sophie Vermond, Sophie Hill, et al. "Abstract LB009: Safety profile assessment for IND-enabling studies: Bispecific antibodies and antibody-drug conjugates (ADCs)." Cancer Research 85, no. 8_Supplement_2 (2025): LB009. https://doi.org/10.1158/1538-7445.am2025-lb009.

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Abstract Developing antibody-based therapeutics requires balancing potency and safety. Off-target effects can cause adverse events, necessitating precise target engagement and comprehensive safety profiling during early development. The work presented outlines a systematic approach to identify and mitigate off-target interactions for antibodies and ADCs. This de-risking roadmap which spans 12-16 weeks, evaluates on-target and off-target interactions, ensuring thorough vetting before IND-enabling studies. The de-risking platform uses two primary approaches: (1) Off-target analysis via Retrogeni
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Corsi, Giulia I., Veerendra P. Gadekar, Jan Gorodkin, and Stefan E. Seemann. "CRISPRroots: on- and off-target assessment of RNA-seq data in CRISPR–Cas9 edited cells." Nucleic Acids Research 50, no. 4 (2021): e20-e20. http://dx.doi.org/10.1093/nar/gkab1131.

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Abstract The CRISPR-Cas9 genome editing tool is used to study genomic variants and gene knockouts, and can be combined with transcriptomic analyses to measure the effects of such alterations on gene expression. But how can one be sure that differential gene expression is due to a successful intended edit and not to an off-target event, without performing an often resource-demanding genome-wide sequencing of the edited cell or strain? To address this question we developed CRISPRroots: CRISPR–Cas9-mediated edits with accompanying RNA-seq data assessed for on-target and off-target sites. Our meth
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Hernández, José Esteban. "Acquisition of The Tap-Trill-Lateral Contrast by Speakers of L1 Cantonese-L2 Spanish." Revista de Filología y Lingüística de la Universidad de Costa Rica 51, no. 1 (2025): e63517. https://doi.org/10.15517/rfl.v51i1.63517.

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In the present study an assessment of the on-target and off-target production of liquids (laterals and rhotics) is undertaken in a corpus of second language (L2) Spanish. The Chinese-origin participants have immigrated to Mexicali, Mexico where they have acquired L2 Spanish in a natural setting. As a major aim, a quantitative analysis of the data is performed to determine the production of on-target and off-target articulations in lateral, tap, thrill, and syllable-coda rhotic. Internal and external factors are considered in the analysis; for example, liquid production in syllable onset, coda
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Fischer, André, Manuel Sellner, Karolina Mitusińska, et al. "Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2." International Journal of Molecular Sciences 22, no. 4 (2021): 2065. http://dx.doi.org/10.3390/ijms22042065.

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The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a serious global health threat. Since no specific therapeutics are available, researchers around the world screened compounds to inhibit various molecular targets of SARS-CoV-2 including its main protease (Mpro) essential for viral replication. Due to the high urgency of these discovery efforts, off-target binding, which is one of the major reasons for drug-induced toxicity and safety-related drug attrition, was neglected. Here, we used molecular docking, toxicity profiling, and multiple molecular dynamics (
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Zhao, Hui, and Jeffrey D. Wolt. "Risk associated with off-target plant genome editing and methods for its limitation." Emerging Topics in Life Sciences 1, no. 2 (2017): 231–40. http://dx.doi.org/10.1042/etls20170037.

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Assessment for potential adverse effects of plant genome editing logically focuses on the specific characteristics of the derived phenotype and its release environment. Genome-edited crops, depending on the editing objective, can be classified as either indistinguishable from crops developed through conventional plant breeding or as crops which are transgenic. Therefore, existing regulatory regimes and risk assessment procedures accommodate genome-edited crops. The ability for regulators and the public to accept a product focus in the evaluation of genome-edited crops will depend on research w
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Zhang, Weiwei, Jianhang Yin, Zhengrong Zhang-Ding, et al. "In-depth assessment of the PAM compatibility and editing activities of Cas9 variants." Nucleic Acids Research 49, no. 15 (2021): 8785–95. http://dx.doi.org/10.1093/nar/gkab507.

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Abstract A series of Cas9 variants have been developed to improve the editing fidelity or targeting range of CRISPR–Cas9. Here, we employ a high-throughput sequencing approach primer-extension-mediated sequencing to analyze the editing efficiency, specificity and protospacer adjacent motif (PAM) compatibility of a dozen of SpCas9 variants at multiple target sites in depth, and our findings validate the high fidelity or broad editing range of these SpCas9 variants. With regard to the PAM-flexible SpCas9 variants, we detect significantly increased levels of off-target activity and propose a trad
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Conroy, A., E. Vilchez, D. Nguyen, et al. "AMPLIFYBIO TCR SPECIFICITY PLATFORM: BETTER OFF-TARGET ASSESSMENT FOR SAFER TCR-BASED THERAPIES." Cytotherapy 26, no. 6 (2024): S187. http://dx.doi.org/10.1016/j.jcyt.2024.03.371.

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Dissertations / Theses on the topic "Off-target assessment"

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Bourgeois, Karine. "Towards in vitro Pharmacokinetic Assessment of Novel Targeted Covalent Inhibitors for Human Tissue Transglutaminase." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39472.

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Human tissue transglutaminase (TG2) is a calcium-dependent multifunctional enzyme that natively catalyzes the post-translational modification of proteins, namely by the formation of isopeptide bonds between protein- or peptide-bound glutamine and lysine residues. This ubiquitously expressed enzyme plays important roles in cellular differentiation, extracellular matrix stabilization, and apoptosis, to name a few. However, its unregulated activity has been associated with many pathologies such as fibrosis, cancer, neurodegenerative disorders and celiac disease. Most of these disorders are associ
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Cancellieri, Samuele. "Personal genome editing algorithms to identify increased variant-induced off-target potential." Doctoral thesis, 2022. http://hdl.handle.net/11562/1058995.

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Clustered regularly interspaced short palindromic repeats (CRISPR) technologies allow for facile genomic modification in a site-specific manner. A key step in this process is the in-silico design of single guide RNAs (sgRNAs) to efficiently and specifically target a site of interest. To this end, it is necessary to enumerate all potential off-target sites within a given genome that could be inadvertently altered by nuclease-mediated cleavage. Off-target sites are quasi-complementary regions of the genome in which the specified sgRNA can bind, even without a perfect complementary nucleotid
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Book chapters on the topic "Off-target assessment"

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Naegeli, Hanspeter, Gijs Klete, and Antje Dietz-Pfeilstetter. "Food and feed safety assessment of RNAi plants and products." In RNAi for plant improvement and protection. CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0013.

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Abstract This paper evaluates the potential hazards of food and feed derived from RNAi plants including: adverse changes of plant metabolism; mechanisms and potential for non-target gene silencing in humans and livestock, including gut microbiome; bioinformatics tools for predictionof off-target sequences of interfering RNA; the possible non-specific effects of dsRNA and siRNA in mammals; and the comparison of data requirements for safety assessment of food and feed from RNAi plants and from plants expressing recombinant proteins. It also discusses exposure and RNAi-specific risk assessment.
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Naegeli, Hanspeter, Gijs Klete, and Antje Dietz-Pfeilstetter. "Food and feed safety assessment of RNAi plants and products." In RNAi for plant improvement and protection. CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0131.

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Abstract This paper evaluates the potential hazards of food and feed derived from RNAi plants including: adverse changes of plant metabolism; mechanisms and potential for non-target gene silencing in humans and livestock, including gut microbiome; bioinformatics tools for predictionof off-target sequences of interfering RNA; the possible non-specific effects of dsRNA and siRNA in mammals; and the comparison of data requirements for safety assessment of food and feed from RNAi plants and from plants expressing recombinant proteins. It also discusses exposure and RNAi-specific risk assessment.
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Topp, Max, and Tobias Feuchtinger. "Management of Hypogammaglobulinaemia and B-Cell Aplasia." In The EBMT/EHA CAR-T Cell Handbook. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94353-0_28.

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AbstractThe development and regulatory approval of CAR-T cell therapies targeting B-lineage surface antigens (Maude et al. 2018), such as CD19 or CD22, represents a major milestone in cancer immunotherapy. This treatment results in the depletion of malignant and normal B cells and is associated with hypogammaglobulinaemia. These on-target, off-tumour toxicities may result in an increased risk of infection. Careful long-term follow-up assessment of patients receiving CAR-T cell therapy is important. Management of these on-target, off-tumour effects should be well coordinated between treatment a
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Sjöberg, Ronald, Eni Andersson, Cecilia Hellström, et al. "High-Density Antigen Microarrays for the Assessment of Antibody Selectivity and Off-Target Binding." In Epitope Mapping Protocols. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7841-0_15.

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Drevon, Daniel D., and Michael D. Hixson. "Reductive Interventions." In Handbook of Behavioral Interventions in Schools. Oxford University Press, 2019. http://dx.doi.org/10.1093/med-psych/9780190843229.003.0015.

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Schools ordinarily support establishing or increasing target behaviors, for example, increasing the number of letter sounds mastered or the frequency of social initiations; however, supporting the reduction of target behaviors is also an important goal of behavior analytic practice in schools. Although numerous target behaviors may warrant functional assessment and subsequent reduction at the individual level (e.g., aggression, self-injurious behavior), this chapter focuses on describing the implementation of and research outcomes related to reductive interventions designed to help teachers de
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"Marine Artificial Reef Research and Development: Integrating Fisheries Management Objectives." In Marine Artificial Reef Research and Development: Integrating Fisheries Management Objectives, edited by Tiffanie A. Cross, Beverly Sauls, Rachel Germeroth, and Keith Mille. American Fisheries Society, 2018. http://dx.doi.org/10.47886/9781934874516.ch16.

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<em>Abstract</em>.—Florida boasts an abundance of natural and artificial reefs that support a large and diverse recreational fishery off the Gulf of Mexico coast. Recent efforts to mitigate the effects of the <em>Deepwater Horizon </em>oil spill have increased the number of artificial reefs deployed off Florida’s Gulf Coast. Fisheries-dependent data are needed to assess whether artificial reef programs are meeting intended objectives and to understand changes in recreational angler behavior, which may influence catch per unit effort and biomass of landed fish. The objec
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Young, Emily, and Sherif Zaky. "Principles of Doppler Ultrasound." In Basic Anesthesia Review, edited by Alaa Abd-Elsayed. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197584569.003.0018.

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Abstract Doppler ultrasound is a modality that can be used to examine the direction, velocity, and pattern of blood flow in a vessel. This imaging modality uses the principles of the Doppler effect to detect movement within body tissues. It is most often used to examine the direction, speed, and pattern of blood flow in a target vessel or across a valve. Doppler ultrasound works by detecting shifts in frequency that occur when sound waves reflect off a moving surface. If an object is moving toward the ultrasound probe, the reflected frequency of the ultrasound beam is shifted higher. If an obj
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Khan, Bushra, Shifa Ahmad, Madhurima Tiwari, and Dr Deepika Delsa. "STRAIN IMPROVEMENT BY CRISPR/Cas9 FOR ENHANCING BIOFUEL PRODUCTION." In Futuristic Trends in Biotechnology Volume 3 Book 21. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkbt21p1ch1.

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The rapid progress in synthetic biology and metabolic engineering presents significant opportunities for the development of advanced biofuels. These fuels offer higher yields and efficiency while reducing carbon emissions. The clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins (CRISPR-Cas9) technology is one of the significant developments in molecular biology. Compared to prior techniques like zinc finger nucleases (ZFN) and transcription activator-like effector nucleases (TALEN), it allows more precise genome editing with increased precision. Despite researc
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Conference papers on the topic "Off-target assessment"

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Schmitz, Carl, Jacob Bradford, Robert Salomone, and Dimitri Perrin. "Fast and scalable off-target assessment for CRISPR guide RNAs using partial matches." In 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2024. https://doi.org/10.1109/bibm62325.2024.10822812.

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Roy, Gilles, Xiaoying Cao, and Simon Roy. "Helicopter Flight Test of the Obscurant Penetrating Autosynchronous Lidar (OPAL) in Degraded Visual Environments: Part II - See-through Capability Assessment." In Vertical Flight Society 70th Annual Forum & Technology Display. The Vertical Flight Society, 2014. http://dx.doi.org/10.4050/f-0070-2014-9597.

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In support to the Directorate of Technical Airworthiness and Engineering Support (DTAES-6) of Canada's Department of National Defence (DND), DRDC Valcartier is currently evaluating the Obscurant Penetrating Autosynchronous Lidar (OPAL) developed by Neptec Technologies Corp. This sensor is targeted at supporting rotary-wing aircraft operating in degraded visual environments (DVE) during critical flight phases (i.e. take-off and landing). OPAL consists of a scanning pulsed lidar that generates 3D images of obstacles on the landing zone that are engulfed in an obscurant cloud. The sensor performa
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Mikhaylova, Y. V., M. A. Tyumentseva, A. A. Shelenkov, Y. G. Yanushevich, A. I. Tyumentsev, and V. G. Akimkin. "ASSESSMENT OF EFFICIENCY AND OFF-TARGET ACTIVITY OF CRISPR/CAS RIBONUCLEOPROTEIN COMPLEXES." In Molecular Diagnostics and Biosafety. Federal Budget Institute of Science 'Central Research Institute for Epidemiology', 2020. http://dx.doi.org/10.36233/978-5-9900432-9-9-98.

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In this study, we assessed the efficiency and off-target activity of the CRISPR/CAS complex with one of the selected guide RNAs using the CIRCLE-seq technology. The gene encoding the human chemokine receptor CCR5 was used as a target sequence for genome editing. The results of this experiment indicate the correct choice of the guide RNA and efficient work of the CRISPR- CAS ribonucleoprotein complex used. CIRCLE-seq technology has shown high sensitivity compared to bioinformatic methods for predicting off-target activity of CRISPR/CAS complexes. We plan to evaluate the efficiency and off-targe
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Grindon, Elizabeth, Neil Harman, Carmen Niculae, Ming Leang Ang, Hironobu Iwanami, and Tomoharu Hashimoto. "Development and Application of Level 3 PSA for the UK ABWR Generic Design Assessment." In 2018 26th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icone26-81469.

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A full scope Probabilistic Safety Assessment (PSA) was provided as an integral part of the safety case for the UK ABWR Generic Design Assessment (GDA) and this included a Level 3 PSA. The main objectives of the Level 3 PSA for GDA are to provide a demonstration of the compliance, for a single unit UK ABWR, with numerical risk targets defined in the UK Safety Assessment Principles and to support the ALARP assessment. This paper includes: • An overview of the methodology, PSA model development and illustration of some results. • A summary of the key assumptions made during the model development
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Fischer, Maximilian, Denis Heckmann, and Alexander Nase. "Assessment of the Operational Costs and the Passengers' Willingness-to-Pay to Evaluate the Financial Viability of an Air Taxi Service." In Vertical Flight Society 77th Annual Forum & Technology Display. The Vertical Flight Society, 2021. http://dx.doi.org/10.4050/f-0077-2021-16820.

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Several cities and regions have announced to launch electric Vertical Take-Off and Landing (eVTOL) based air taxi services in the future. To successfully implement such services, the financial viability must be assessed. As part of the project "SkyCab", an eVTOL based air taxi service concept was designed, associated costs to set-up such service assessed, major impact factors on the pricing identified and the willingness-to-pay of the target customers evaluated. The paper outlines the approach to evaluate the financial viability within five steps. First, the target customer group is identified
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Kim, Nam H., Michael Wininger, Gail Forrest, Thomas Edwards, and William Craelius. "A Dynamic Speed vs. Accuracy Trade-Off (DSAT) Paradigm for Measuring and Training Grip Force Control for Stroke Population." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206306.

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A fundamental principle of human motor behavior states that the accuracy of targeted movements relates reciprocally to their speed. This is quantified by Fitts’ Law, wherein movement time (MT) and index of difficulty (ID), the log2 ratio of target distance (A) to target height (H) has logarithmic linear relationship; MT = a+b·log2(2A/H) = a+b·ID. The slope, b (seconds/bits), measures targeting performance as the time spent at each difficulty level, expressed as bits of information to be processed by the neuromotor system [1, 2]. Fitts’ paradigm is a common measure of the kinematic performance
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Yoshida, Takero, Yoichi Mizukami, Jinxin Zhou, and Daisuke Kitazawa. "Development of Wireless Control System With Underwater Fish-Eye Camera to Monitor Fish at the Test Site of Marine Renewable Energy." In ASME 2019 38th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/omae2019-95978.

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Abstract Environmental impact assessment is important when marine renewable energy device is installed. Fishermen concern the effect of device on local fish. To confirm the effect before and after installation of marine renewable energy device, we developed wireless monitoring system using an underwater fish eye camera. The camera system is composed of a dome-shaped fish eye lens, a container, and a float. Two thrusters are attached on the container to change the monitoring directions. In the current research, this system was developed to monitor underwater situation around device remotely and
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Scott, Justin, Micah D'Arcangelo, Benjamin Olness, Michele Grimm, and Tamara Bush. "An Assessment of Current Barriers to Accessibility in Public Transportation Pick Up/Drop Off Zones and How Solutions may be Applied to Autonomous Vehicles." In WCX SAE World Congress Experience. SAE International, 2023. http://dx.doi.org/10.4271/2023-01-0713.

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<div class="section abstract"><div class="htmlview paragraph">Challenges that persons with disabilities face with current modes of transportation have led to difficulties in carrying out everyday tasks, such as grocery shopping and going to doctors’ appointments. Autonomous vehicles have been proposed as a solution to overcome these challenges and make these everyday tasks more accessible. For these vehicles to be fully accessible, the infrastructure surrounding them need to be safe, easy to use, and intuitive for people with disabilities. Thus, the goal of this work was to analyze
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Yoshida, Takero, Daisuke Kitazawa, Yoichi Mizukami, Qiaochu Chen, and Akito Mochizuki. "Investigation of Monitoring Fish Using Underwater Fish-Eye Camera at the Test Site of Marine Renewable Energy." In ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/omae2018-77478.

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Assessment of any significant effects on the local marine environment when considering the installation of a marine renewable energy device is of the utmost importance. In particular, the effect of such device on fish is concerned by local fishermen. To confirm variation of fish before and after installing the device of marine renewable energy, we investigated effective monitoring system using an underwater fish-eye camera. In this paper, visibility of the fish-eye camera was tested off Kamaishi city, Iwate prefecture, Japan, which is a test site of marine renewable energy in Japan. Device of
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Lee, Joomyung, Mostafa M. Hamza, Havva Tayfur, Yahya A. Alzahrani, and Mihai A. Diaconeasa. "Probabilistic Risk Assessment Study for Uncertainty Quantification of Spent Pebble-Bed Dry Cask Storage System Operation." In ASME 2023 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/imece2023-117024.

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Abstract The development of on-site interim dry storage systems has become an important issue, not only for existing nuclear power plant (NPP) operations but also for next-generation NPP designs, due to space limitations in the spent fuel pool. To ensure the safety of the spent fuel dry storage system operation, probabilistic risk assessment (PRA) elements are utilized throughout the non-light water reactor (LWR) lifecycle. Uncertainty quantification is an essential aspect to evaluate the risk through PRA performance, particularly in assessing off-site risks associated with advanced NPPs and r
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Reports on the topic "Off-target assessment"

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Quinn, Cathy A., Philip K. Hamilton, Scott D. Kraus, and Christopher K. Slay. An assessment of wounds caused by the attachment of remote sensing tags to North Atlantic right whales (Eubalaena Glacialis): 1988 - 1997. New England Aquarium and Woods Hole Oceanographic Institution, 2023. http://dx.doi.org/10.1575/1912/29702.

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Because of the increase in usage of remote sensing tags to track the migration and movements of cetaceans, it has become increasingly important to assess the impact of such techniques on the target species. Between 1988 and 1997, 55 tags (41 satellite telemetry, 14 VHF or acoustic radio transmitter) were attached to 49 North Atlantic right whales (Eubalaena glacialis). All tags had implantable barbs or were fully implanted below the dermis. Right whales are photographically identifiable and the New England Aquarium curates the North Atlantic catalog, which currently numbers 374 individuals. Th
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Walker, Michael, Gill Holcombe, Clare Mills, Chiara Nitride, and Adrian Rogers. Development of Reference Materials for food allergen analysis. Food Standards Agency, 2023. http://dx.doi.org/10.46756/sci.fsa.hwt621.

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Food hypersensitivity is an increasing problem for many stakeholders with much effort focused on assessment and management of the risks including risk assessment toolkits (for example, the Allergen Bureau (Opens in a new window) Voluntary Incidental Trace Allergen Labelling VITAL®, the iFAAM consortium (Opens in a new window) and the ILSI-Europe Allergen Quantitative Risk Assessment guidance (Opens in a new window)). These toolkits describe the use of action levels and reference doses to assess the risks. A combination of the estimated eliciting dose of allergenic food, (in milligrams as prote
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Ley, Matt, Tom Baldvins, Hannah Pilkington, David Jones, and Kelly Anderson. Vegetation classification and mapping project: Big Thicket National Preserve. National Park Service, 2024. http://dx.doi.org/10.36967/2299254.

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The Big Thicket National Preserve (BITH) vegetation inventory project classified and mapped vegetation within the administrative boundary and estimated thematic map accuracy quantitatively. National Park Service (NPS) Vegetation Mapping Inventory Program provided technical guidance. The overall process included initial planning and scoping, imagery procurement, vegetation classification field data collection, data analysis, imagery interpretation/classification, accuracy assessment (AA), and report writing and database development. Initial planning and scoping meetings took place during May, 2
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Vargas-Herrera, Hernando, Juan Jose Ospina-Tejeiro, Carlos Alfonso Huertas-Campos, et al. Monetary Policy Report - April de 2021. Banco de la República de Colombia, 2021. http://dx.doi.org/10.32468/inf-pol-mont-eng.tr2-2021.

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1.1 Macroeconomic summary Economic recovery has consistently outperformed the technical staff’s expectations following a steep decline in activity in the second quarter of 2020. At the same time, total and core inflation rates have fallen and remain at low levels, suggesting that a significant element of the reactivation of Colombia’s economy has been related to recovery in potential GDP. This would support the technical staff’s diagnosis of weak aggregate demand and ample excess capacity. The most recently available data on 2020 growth suggests a contraction in economic activity of 6.8%, lowe
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