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Dissertations / Theses on the topic 'ORGANIC DERIVATIVES OF HYDRAZINE'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Yazici, Ceyda. "Synthesis Of 4-iodopyrazole Derivatives." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609750/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The electrophilic cyclization of the acetylenic hydrazones initiated by molecular iodine could provide new ways of synthesizing biologically active 4-iodopyrazole derivatives, which are important precursors for the synthesis of highly substituted pyrazole derivatives. For this reason, we investigated the synthesis of 4-iodopyrazole derivatives, such as 1-aryl- 5-alkyl/aryl-4-iodopyrazoles, star

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2

Mingle, David, and Abbas G. Dr Shilabin. "Synthesis, Characterization and Biological Evaluation of novel (S, E)-11-[2-(arylmethylene)hydrazono] pyrrolo [2,1-c] [1,4] benzodiazepine derivatives." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/212.

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Pyrrolo [2,1-c] [1,4] benzodiazepine (PBD) is a class of natural products obtained from various actinomycetes which have both anti-tumor and antibiotic activities. They can bind to specific sequences of DNA that can trigger a biological response which is of pharmacological interest. PBD can also prevent cell division leading to death of the bacteria. This research focuses on the synthesis of novel 11-hydrazinyl PBD derivatives using a multi-step synthesis. PBD-dilactam was initially produced using isatoic anhydride and (L)-proline which was then converted to the PBD-thiolactam using Lawesson's

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3

Mingle, David. "Synthesis, Characterization and Biological Evaluation of Novel (S,E)-11-[2-(Arylmethylene) Hydrazono] Pyrrolo [2,1-c] [1,4] Benzodiazepine Derivatives." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etd/3596.

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Pyrrolo [2,1-c] [1,4] benzodiazepine (PBD) is a class of natural products obtained from various actinomycetes which have both anti-tumor and antibiotic activities and can bind to specific sequences of DNA. PBD-dilactam was initially produced using isatoic anhydride and (L)-proline which was then converted to the PBD-thiolactam using Lawesson's reagent. Reaction of thiolactam with hydrazine in ethanol afforded PBD-11-hydrazinyl. Condensation of 11-hydrazinyl PBD with aldehydes possessing various substitutions was performed to obtain (S,E)-11-[2-(arylmethylene) hydrazono] pyrrolo [2,1-c] [1,4] b

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4

Aumand, Livia M. "A Studies towards the formation of asymmetric quaternary centres via radical allylation B Applications of chiral hydrazide organocatalysts to Diels-Alder, hydride reduction, and alpha-chlorination reactions C Studies directed towards the synthesis of potential HIV-1 reverse transcriptase inhibitors: 9-Alkylaryl TIBO derivatives." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/26843.

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In part A, the attempts at synthesizing quaternary centres via radical reactions are described. Using tartrate acetals as chiral auxiliaries, tertiary bromides were submitted to radical allylation conditions in an effort to form 1,3-dicarbonyl compounds 27 possessing an asymmetric quaternary centre at C2.* Part B describes the synthesis of chiral hydrazide 129 and its ability to catalyze the Diels-Alder reaction is examined. The application of chiral hydrazides 131 to the organocatalytic hydride reduction of alpha,beta-unsaturated aldehydes and the alpha-chlorination of aldehydes is also recou

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5

Thompsett, David. "Hydrazine and carbazate complexes of chromium and manganese : their role in the catalytic decomposition of hydrazine." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376340.

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6

Ghassemi, Hossein. "Synthesis and properties of novel polyimides utilizing hydrazine." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28451.

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Hydrazine reacts with phthalic anhydride to give a mixture of cyclic hydrazide and N-aminophthalimide. However, the N-aminoimide is exclusively formed in high yield by the reaction of 1,8-naphthalic anhydride with hydrazine. N-aminoimides act as amines and react further with cyclic anhydrides to yield stable bisimides containing an N-N linkage. The syntheses of several bis(N-aminoimide)s from the corresponding bisanhydrides which contain the naphthalic anhydride moiety have been described. Novel high molecular weight polyimides have been synthesized by the reaction of these bis(N-aminoimide)s

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7

Chen, Lingyan. "CaSH (camphor sulfonyl hydrazine) and CSI (chiral sulfonimide) organocatalysis." HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1186.

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8

Bollan, Hilary Roberta. "The detection of hydrazine and related materials by ion mobility spectrometry." Thesis, Sheffield Hallam University, 1998. http://shura.shu.ac.uk/19366/.

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A technique known as ion mobility spectrometry (IMS), which has been under development for about thirty years, has been shown to be capable of detecting hydrazines at low concentrations but with interference from ammonia. Ammonia is usually present in hydrazine environments, as a breakdown product or a by-product of the human metabolism. This project was undertaken to investigate mechanical and chemical parameters for improved detection of these hydrazines in the presence of ammonia, and for the detection of nitrogen dioxide, by IMS. The subject areas investigated were compatibility of detecto

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9

Clavette, Christian. "Synthesis of Beta-Aminocarbonyl Compounds and Hydrazine Derivatives Using Amino- and Imino-Isocyanates." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32004.

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Over the past recent years, β-aminocarbonyls have been of great interest to medicinal chemists. As a practical method to obtain these moieties, alkene aminocarbonylation, accounting for the formation of a C-N and a C-C bond, has been the subject of limited research efforts (very specific intramolecular metal-catalyzed variants have been reported). Direct aminocarbonylation of alkenes constitutes a challenging and an important potential innovation in the synthesis of β-aminocarbonyls such as β-amino acids. The research efforts described in the present thesis have been primarily directed towards

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10

He, Hao. "Organocatalysis : hydrazine and sulfonimide as new functionalities in asymmetric organocatalysis." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1104.

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11

Fox, Mark Alexander. "Icosahedral carborane derivatives." Thesis, Durham University, 1991. http://etheses.dur.ac.uk/1186/.

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12

Mojica, Mike. "Investigation of new synthetic reactions: the synthesis of hydrazines via the Aza-Lossen rearrangement, the synthesis of carbamoyl azides from amines, and deprotection reactions using water at elevated temperatures." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51791.

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This thesis explores three rare synthetic routes: the synthesis of hydrazines via the aza-Lossen rearrangement, the synthesis of carbamoyl azides from amines, and deprotection reactions using water at elevated temperatures. The aza-Lossen reaction was found to be ideal at “infinite dilution” conditions and could be performed with both aryl and alkyl example. Carbamoyl azides could be synthesized in high yields from both aryl and alkyl amines. The carbamoyl azide reaction was found to be much more efficient with Cs (+1) present. Lastly, water at elevated temperatures conditions was efficient at

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13

Wardell, Ian. "Heterodiene cycloadditions of benzopyran derivatives." Thesis, University of Salford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358716.

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14

Destabel, Christine. "Radical cyclisations of methylenecyclopropane derivatives." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241266.

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15

Pike, Kurt Gordon. "Radical cyclisations of methylenecycloropane derivatives." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242694.

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16

Brown, Martyn A. "Phosphorus and arsenic carbohydrate derivatives." Thesis, University of Aberdeen, 1993. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU552502.

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A series of O-diphenylphosphinyl monosaccharide derivatives, e.g. 1,2:5,6-di-O-cyclohexylidene-3-O-diphenyl phosphinyl--D-glucofuranose [60], has been synthesised by reaction of a free hydroxy group in a sugar with Ph_2PCl. C-Diphenylphosphinyl and diphenylarsino derivatives, e.g. methyl 4,6-O-benzylidene-3-deoxy-3-C-diphenylarsino--D-altropyranoside [89], were synthesised via reaction of Ph2PLi or Ph2AsLi with p-tosyl, mesyl, epoxy or carbonyl substituted sugar reagents. Steric factors play a large part in determining the reactivity of the precursor sugars towards the phosphorous or arsenic n

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17

Priefer, Ronny. "Sulfur functionalized cubane and related derivatives." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84418.

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Chapter one of this thesis reviews some work on cubane, from its initial synthesis by Eaton in 1964, to the recent studies of explosive and medicinal applications. Considering the wide variety of compounds that have been synthesized, it is curious that sulfur functionalized cubane has received virtually no attention.<br>Chapter two discusses the synthesis of cubanethiol, dicubyl disulfide, and a range of derivatives. Dicubyl disulfide possesses the shortest C-S bond length of any reported molecule where the carbon is sp3 hybridized. Calculations have confirmed that this apparently resul

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18

Nomura, Glenn Sterling. "Derivatives of 4-ketoperhydroazulene with bridgehead methyl groups." Diss., Georgia Institute of Technology, 1985. http://hdl.handle.net/1853/27064.

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19

Ling, Kenneth B. "Stereoselective cyclopropanations of allylic amines and derivatives." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:15907329-15e7-4cbd-ba46-2735ff4129ea.

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This thesis is concerned with the development and application of methods for the stereoselective cyclopropanation of allylic amines and derivatives. Firstly, a highly chemo- and stereoselective cyclopropanation of N,N-dibenzyl-protected allylic amines was developed using the highly reactive Shi’s carbenoid [CF₃CO₂ZnCH₂I]. Subsequent mechanistic studies revealed that the high diastereoselectivity of the reaction was likely to be due to coordination of the amine to the zinc carbenoid reagent. It is then shown that the reaction is general for a wide range of both cyclic and acyclic substrates giv

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20

Liang, Yi. "Carbohydrate Derivatives in Antibiotics Research." DigitalCommons@USU, 2009. https://digitalcommons.usu.edu/etd/298.

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In this study, we investigated the potential applications of carbohydrates in the development of new antibiotics. To tackle the problem of multidrug-resistant variants of M. tuberculosis (MDR-TB), we investigated the biosynthesis pathways of trehalose, which has contributed to significant drug resistance. Some new methods were developed for the synthesis of potential inhibitors (6-azido-trehalose and 6,6'-diazido-trehalose) that have been designed to imitate the intermediate molecule (trehalose 6-phosphate, TPP) of OtsA-OtsB pathway. At the same time, some new antibacterial agents based on tre

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21

Rajviroongit, Shuleewan. "Cyclisation and cycloaddition of imine derivatives." Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335436.

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22

Holmes, D. "Studies of thieno[b]pyridine derivatives." Thesis, Nottingham Trent University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355320.

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23

Wilkins, D. J. "Synthesis of biologically active indole derivatives." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374829.

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24

Box, Julian M. "Towards fluorinated derivatives of shikimic acid." Thesis, University of Reading, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286003.

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25

Kolb, Daniel. "Organic transistors based on pentacene and dibenzothiophene derivatives." Thesis, Durham University, 2008. http://etheses.dur.ac.uk/2189/.

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This thesis is concerned with the fabrication and characterisation of organic thin film transistors. Initially, pentacene thin films were investigated, with results comparable to those found in published literature. Initial studies of pentacene transistors revealed a poor hole mobility of 6.3 x 10(^-3) cm(^2)/V/s. Improvements in the fabrication process (using a more conductive silicon wafer as the gate, and treating the silicon oxide surface with a silanising agent) increased the mobility to around 0.1 cm(^2)/V/s. Better pentacene deposition conditions allowed a polycrystalline structure to f

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26

Holmes, Stephen Anthony. "Organic derivatives of ytterbium and related 4f-elements." Thesis, University of Sussex, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701980.

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27

Ramaite, Ipfani David Isaiah. "Synthetic and physical organic studies of chromone derivatives." Thesis, Rhodes University, 1997. http://hdl.handle.net/10962/d1005045.

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A range of chromone-2-carboxylic acids has been prepared by condensing suitably substituted 2-hydroxyacetophenones with diethyl oxalate. pK₂ Studies of these acids revealed that 6- or 7-methoxy substituents decreased acidity while the 6-nitro group enhanced acidity; the strongest acid was the 3-chloro derivative, the increase in acidity being attributed to steric inhibition of acid-weakening delocalisation between the carboxyl group and the chromone system. Various chromone-2-carboxamides, derived from acid chloride precursors, were converted to polysubstituted acrylamides by nucleophilic ring

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28

Waghela, M. B. "Pyrrolizine derivatives of potential medicinal interest." Thesis, De Montfort University, 1986. http://hdl.handle.net/2086/13287.

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29

Boa, Andrew Neil. "The asymmetric synthesis of alpha-fluoroglycine derivatives." Thesis, University of York, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306416.

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30

Peron, Guillaume Luc Nicolas. "Lewis acid mediated cyclisation of methylenecyclopropane derivatives." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326304.

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31

Humphreys, Joshua. "Synthesis and characterisation of novel diketopyrrolopyrrole derivatives." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52863/.

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The main goal of this thesis was to design new small molecule DPP derivatives, which could have a multitude of potential applications in areas such as organic electronics and sensors. Based on literature precedent, four factors were chosen to manipulate in the design of novel DPP systems: the electron richness of the aryl unit, π - π stacking, chirality and hydrogen bonding. The influence of these modifications to the DPP system on the optical, electronic and structural properties was then investigated to screen materials for potential applications in the aforementioned areas and to gain great

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32

Laha, Rumita. "Novel Isosteviol Derivatives as Potential Anticancer Agents." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1512733339403396.

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33

Harkness, Brian Robert. "The chiroptical properties of specifically substituted cellulose derivatives /." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74541.

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Several novel cellulose derivatives with triphenylmethyl or 1-methylnaphthalene substituents at the primary hydroxyl positions and n-alkyl or benzyl substituents at the secondary hydroxyl positions have been prepared and characterized. The 6-O-trityl-2,3-O-alkyl cellulose and 6-O-trityl-2,3-O-benzyl cellulose derivatives form lyotropic chiral nematic liquid crystalline phases that display reflection colours. Both left and right-handed chiral nematic phases have been observed; the twist sense depends on the nature of the side-group substitution and the solvent. The chiroptical activity of the p

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34

Gao, Feng. "Synthesis of aminoglycoside derivatives to combat bacterial resistance." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18273.

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Aminoglycosides are broad spectrum antibiotics that act by binding to 16S rRNA of bacteria. The wide spread of aminoglycoside resistance threatens the use of these important medicines. Two general approaches can be used to address the aminoglycoside resistance problem. One is to derive the existing aminoglycoside antibiotics; the other is to develop inhibitors blocking resistance pathways.We developed a novel methodology to regio- and chemo-selectively derivatize unprotected aminoglycosides at the N-6' position, and used this method to prepare a series of amide-linked aminoglycoside-CoA bisubs

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35

ametsetor, ebenezer, Emmanuel Onobun, and Ismail Kady. "Synthesis of Hydroxytyrosol Derivatives." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/64.

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Hydroxytyrosol is one of the most powerful known antioxidants. It is a naturally occurring polyphenol, most commonly produced in Olive tree, (Olea europaea). The remarkable antioxidant and pharmacological properties of hydroxytyrosol has made it an outstanding compound in the polyphenol family and of great interest to many researchers. Hydroxytyrosol has the ability to scavenge free radicals produced during cellular oxidative stress and helps to protect the integrity of cells in living systems. Despite its numerous biological and pharmacological uses, it is found in very low concentration in o

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36

Ametsetor, Ebenezer. "Synthesis and Study of Hydroxytyrosol Derivatives." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etd/3643.

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Hydroxytyrosol is one of the most powerful known antioxidants. It is a naturally occurring polyphenol, most commonly produced in olive trees, (Olea europaea). The remarkable antioxidant and pharmacological properties of hydroxytyrosol has made it an outstanding compound in the polyphenol family and of great interest to many researchers. Hydroxytyrosol can scavenge free radicals produced during cellular oxidative stress and helps to protect the integrity of cells in living systems. Despite its numerous biological and pharmacological uses, it is found in very low concentration in olive oil, this

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37

Duygu, Arife Nese. "Synthesis Of Camptothecin Derivatives." Phd thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606302/index.pdf.

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This study presents synthetic studies on camptothecin, a potent antitumor agent in order to improve its stability and solubility without reducing its activity. The study consists of the modification of camptothecin at 20-OH position a new strategy for the targeted and controlled release of the drug and modification at C-7 position to overcome the stability and solubility problems of the free drug. In the first part of the study, the 20-OH functional group of camptothecin was replaced with an unsymmetrical benzoin derivative that is able to release the drug under photolysis at 350 nm. The new

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38

Soucy-Breau, Chantal. "Synthesis of naturally occurring phototoxic thiophenes and their derivatives." Thesis, University of Ottawa (Canada), 1990. http://hdl.handle.net/10393/5712.

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Analogues and derivatives of naturally occurring $\alpha$-terthienyl 3 have been synthesized by using the nickel-catalyzed Grignard-Wurtz cross-coupling reaction. This method has proven useful for the introduction of non-polar substituents on 2-bromothiophene which upon subsequent cross-coupling with 5-iodo-$\alpha$-dithienyl 185 led to a successful variety of 5-substituted $\alpha$-terthienyls. Derivatives of $\alpha$-terthienyl bearing polar functional groups were synthesized either by: (1) introduction of electron-withdrawing and electron-donating at C-5 and C-5$\sp{\prime\prime}$; or (2) c

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39

Bradley, Jean-Claude. "The synthesis and reactivity of 2-benzylidenebenzocyclobutenones and derivatives." Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/6918.

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Chapter 1. A brief overview of the preparation and uses of o-quinodimethanes and benzocyclobutenes is presented. Chapter 2. The preparation of benzylidenebenzocyclobutene analogs from acetylenic precursors is presented. The strategy initially involves addition of tributyltin hydride to acetylenes via free-radical or palladium catalysed processes. The resulting vinylstannanes then undergo an intramolecular Stille coupling to yield benzocyclobutenes. For (o-bromoaryl)phenylalkynones, both steps were mediated by palladium catalysis, thus leading to a convenient one-pot synthesis of 2-benzylideneb

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40

Quevillon, Sophie. "Toward diversity-oriented synthesis of indoline-based polycyclic derivatives." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26425.

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There is a growing interest in using diversity-oriented synthesis (DOS) to generate small molecule libraries that are inspired by bioactive natural products. Over the years they have proven to be quite valuable chemical probes for understanding protein functions. Of particular interest is the design of natural product-like chiral scaffolds in which one could explore the three dimensional space around the building block by having several chiral diversity sites. A novel synthesis to reach an indoline scaffold is described. This template is then utilized to synthesize a seven-membered ring tricyc

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41

Skiti-Mama, Neliswa. "Novel camphor derivatives as potential asymmetric alkylation auxiliaries." Thesis, Nelson Mandela Metropolitan University, 2008. http://hdl.handle.net/10948/1077.

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The investigation has been focussed on the synthesis and characterisation of camphor-derived chiral auxiliaries that incorporate two camphor skeletons and an evaluation of their stereodirecting potential in ester α-benzylation reactions. Two regioisomeric camphorquinone-derived monoketals were synthesised and identified by 1D- and 2D-NMR, and X-ray crystallography. The stereo-directing potential of the alcohols that resulted from reduction of these ketones as chiral auxiliaries in the alkylation of carboxylate ester derivatives has been studied. The diastereoselectivities shown by NMR spectros

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42

Cave, John Maxwell. "Synthesis and spectroscopic studies of some dibenzofuran derivatives." Thesis, University of Hull, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306023.

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43

Lothian, Aileen Patricia. "The synthesis and properties of novel imidazole derivatives." Thesis, Keele University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296074.

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44

Whitby, Paul Howard. "Free radical approaches to fluorinated derivatives of Amines." Thesis, Durham University, 1992. http://etheses.dur.ac.uk/5605/.

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A. The C-H bond is used as a functional group in free radical addition of nitrogen containing compounds to a variety of fluoroalkenes. Substituent effects are explained using the trimethylsilyl and acetyl derivatives of a range of both aliphatic and alicyclic amines, and studies are described on the effect of introducing a second heteroatom on the reactivity of these derivatives. Further reactions of some of the adducts gave synthetic routes to fluorinated amines. B. Attempts at direct fluorination of tertiary amide models for RDX explosives are described using a range of techniques from high

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45

Williams, Dafydd E. "Chemoenzymatic approach to sialyl Lewis'x and its derivatives." Thesis, University of Warwick, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390229.

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46

Herpin, Timothee Felix. "Some new reactions of anomeric difluoromethylene carbohydrate derivatives." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336240.

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47

Norris, Simon Richard. "Studies towards the synthesis of useful proline derivatives." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315897.

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48

Al-Jebouri, Hamza Yaseen. "Synthesis of butadiene sulphone derivatives with cyano substituents." Thesis, University of Surrey, 1985. http://epubs.surrey.ac.uk/847181/.

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The vicinal dicyano compounds are good starting materials for the synthesis of macromolecules such as phthalocyanines and tetrazaporphins. The synthesis of cyano compounds and vicinal dicyano compounds, particularly the cyano derivatives of butadiene sulphones have been studied in this work. This thesis is divided into five chapters as follows: The first chapter contains a general introduction about organic cyanides; their preparations, reactions and applications. In the second chapter, the synthesis of butadiene sulphone derivatives leading to mono and dicyano substituents is dealt with. It i

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49

Garden, Simon J. "Studies of alkoxy- and hydroxy-C-stannylated derivatives." Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU547238.

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New organotin compounds containing hydroxy- and alkoxy-functionality have been prepared. Synthesis of these organotin compounds has focused on the use of carbohydrate derivatives, from which both protected and unprotected carbohydrate organotin derivatives have been prepared. The methods of synthesis have involved the use of organotin hydrides (Ph3SnH and PhMe2SnH) and their addition to an allyl sugar and on the nucleophilic substitution of -halomethyltin compounds [Ph_4-n-mMe_mSn(CH_2I)_n]. The structures of products have been investigated in the solid state by. 13C and. 119Sn NMR spectroscop

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50

Smith, David John. "Complexation of amino-acid derivatives using macrocyclic receptors." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319219.

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