Log in

Relevant bibliographies by topics / ORGANIC DERIVATIVES OF HYDRAZINE / Journal articles

To see the other types of publications on this topic, follow the link: ORGANIC DERIVATIVES OF HYDRAZINE.

Journal articles on the topic 'ORGANIC DERIVATIVES OF HYDRAZINE'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'ORGANIC DERIVATIVES OF HYDRAZINE.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Kaur, Aneet Kamal, Renu Bala, Poonam Kumari, Sumit Sood, and Karan Singh. "Microwave Assisted Vilsmeier-Haack Reaction on Substituted Cyclohexanone Hydrazones: Synthesis of Novel 4,5,6,7-Tetrahydroindazole Derivatives." Letters in Organic Chemistry 16, no. 3 (2019): 170–75. http://dx.doi.org/10.2174/1570178615666180917101637.

Full text

Abstract:

Vilsmeier-Haack reaction is one of the most important chemical reactions used for formylation of electron-rich arens. Even though Vilsmeier-Haack reaction was studied on a wide variety of hydrazones of enolizable ketones, literature lacks the examples of the use of 4-substituted cyclohexanones as a substrate. The cyclization potential of hydrazones of cyclic keto compounds is still interested topic of investigation. In the present study, the reaction of various hydrazines with 4-substituted cyclohexanones was proceeded and the resulted hydrazones in crude form were treated with Vilsmeier- Haac

APA, Harvard, Vancouver, ISO, and other styles

2

Sapkota, Kamal Raj, Shilpi Kumari, Zeba Alam, and Md Serajul Haque Faizi. "Synthesis, and Structural Characterization of (E)-1-(4-((2-(2,4-Dinitrophenyl) hydrazono) methyl)phenyl) piperidine: A Combined Spectroscopic and Computational Study." Bhairahawa Campus Journal 7, no. 1 (2024): 41–55. https://doi.org/10.3126/bhairahawacj.v7i1.79948.

Full text

Abstract:

This study Hydrazine-based piperidine derivatives are widely recognized for their significant roles in pharmaceutical development and material science research. In this context, the present study aimed to synthesize a novel hydrazone derivative to explore its structural and electronic features. This study presents the synthesis and structural characterization of (E)-1-(4-((2-(2,4-Dinitrophenyl)hydrazono)methyl)phenyl)piperidine) (DHP). The compound was obtained through a condensation reaction between 4-(piperidin-1-yl) benzaldehyde and (2,4-dinitrophenyl) hydrazine, achieving an 88% yield. Its

APA, Harvard, Vancouver, ISO, and other styles

3

Wu, Shouting, Xi Liang, Fang Luo, et al. "Synthesis, Crystal Structure and Bioactivity of Phenazine-1-carboxylic Acylhydrazone Derivatives." Molecules 26, no. 17 (2021): 5320. http://dx.doi.org/10.3390/molecules26175320.

Full text

Abstract:

A phenazine-1-carboxylic acid intermediate was synthesized from the reaction of aniline and 2-bromo-3-nitro-benzoic acid. It was then esterified and reacted with hydrazine hydrate to afford phenazine-1-carboxylic hydrazine. Finally, 10 new hydrazone compounds 3a–3j were obtained by the condensation reaction of phenazine-1-carboxylic acid hydrazide and the respective aldehyde-containing compound. The structures were characterized by 1H and 13C NMR spectroscopy, MS and single crystal X-ray diffraction. The antitumor activity of the target compounds in vitro (HeLa and A549) was determined by thia

APA, Harvard, Vancouver, ISO, and other styles

4

Jasril, E. Juwiyatri, S. N. Fauza, and N. Afriana. "Synthesis, in vitro Antioxidant Activity, and Toxicity Evaluation of Hydrazone Derivatives Naphthalene-1-ylmethylene hydrazine." Journal of Physics: Conference Series 2049, no. 1 (2021): 012050. http://dx.doi.org/10.1088/1742-6596/2049/1/012050.

Full text

Abstract:

Abstract Hydrazone is a versatile organic compound that has a basic structure (-NHN=CH-) called the azomethine group. This structure is responsible for the physical and chemical of hydrazone, which makes this compound has variety bioactivities such as antioxidant, antitumor, and anticancer. In this work, two hydrazone derivatives from 1-naphthaldehyde and hydrazine (phenylhydrazine/hydrazine hydrate) have been synthesized under microwave irradiation. Their antioxidant activity and toxicity were evaluated by DPPH and BSLT method, respectively. Structures of the synthesized compounds were confir

APA, Harvard, Vancouver, ISO, and other styles

5

Gera, Ankur, Chander Mohan, and Sandeep Arora. "Synthesis of Phthaloylglycyl Hydrazide Derivatives: Selective Protection of Phthalimide Group from Hydrazinolysis." Current Organic Synthesis 15, no. 6 (2018): 839–45. http://dx.doi.org/10.2174/1570179415666180601083256.

Full text

Abstract:

Background: N-phthalimide amino acid hydrazide is a class of compounds that have the potential therapeutic use. In general, hydrazinolysis of N-substituted amino acid(s) ester removes the ester group and yields the corresponding hydrazide. However, in case if N-substitution group is phthalimide, phthalimide group is cleaved and not the ester group. The resulted compound, therefore, is amino acid ester rather than Nphthalimide amino acid hydrazide. The above class of compounds, because of susceptibility of phthalimide group to hydrazinolysis, has previously been synthesized by a lengthy three-s

APA, Harvard, Vancouver, ISO, and other styles

6

Yehye, Wageeh, and Amit Nath. "Acid Hydrazide: A Potential Reagent for the Synthesis of Semicarbazones." Synthesis 50, no. 21 (2018): 4301–12. http://dx.doi.org/10.1055/s-0037-1609557.

Full text

Abstract:

Complex semicarbazone derivatives were successfully synthesized from substituted semicarbazides in acidic ethanol upon heating in the presence of aldehyde. The reaction is functional group tolerant and chemoselective because no terminal hydrazine moiety is present in the substituted semicarbazides. Thus, functional groups such as esters and acetyls, which are prone to reaction with hydrazine, can also be used in this reaction because the terminal hydrazine moiety of the acid hydrazide was protected by aryl isocyanates in order to prepare substituted semicarbazides. In addition, neither of the

APA, Harvard, Vancouver, ISO, and other styles

7

Timperio, Anna Maria, Sara Rinalducci, and Lello Zolla. "Hydrazide derivatives produce active oxygen species as hydrazine." Bioorganic Chemistry 33, no. 6 (2005): 459–69. http://dx.doi.org/10.1016/j.bioorg.2005.09.001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

El-Naggar, Mohamed, Abd El-Galil E. Amr, Ahmed A. Fayed, Elsayed A. Elsayed, Mohamed A. Al-Omar, and Mohamed M. Abdalla. "Potent Anti-Ovarian Cancer with Inhibitor Activities on Both Topoisomerase II and V600EBRAF of Synthesized Substituted Estrone Candidates." Molecules 24, no. 11 (2019): 2054. http://dx.doi.org/10.3390/molecules24112054.

Full text

Abstract:

A series of 16-(α-alkoxyalkane)-17-hydrazino-estra-1(10),2,4-trien[17,16-c]-3-ol (3a–l) and estra-1(10),2,4-trien-[17,16-c]pyrazoline-3-ol derivatives (4a–d) were synthesized from corresponding arylidines 2a,b which was prepared from estrone 1 as starting material. Condensation of 1 with aldehydes gave the corresponding arylidine derivatives 2a,b which were treated with hydrazine derivatives in alcohols to give the corresponding derivatives 3a–l, respectively. Additionally, treatment of 2a,b with methyl- or phenylhydrazine in ethanolic potassium hydroxide afforded the corresponding N-substitut

APA, Harvard, Vancouver, ISO, and other styles

9

Kirilin, A. D., L. O. Belova, N. I. Kirilina, A. V. Petrogradsky, and N. L. Shembel. "PECULIARITIES OF ISOCYANATES INTERACTION WITH HYDRAZINE DERIVATIVES." Fine Chemical Technologies 13, no. 4 (2018): 39–49. http://dx.doi.org/10.32362/2410-6593-2018-13-4-39-49.

Full text

Abstract:

The results of studies on chemical transformations of organic and organosilicon isocyanates in their interaction with hydrazine derivatives have been summarized in this review. It is shown that hydrazine and its derivatives including organosilicon compounds reacting with organic isocyanates form corresponding semicarbazides readily enough. The reaction conditions that effect the composition, structure and yield of the resulting target products are presented. A significant difference in the interaction of trimethylsilyl isocyanate with organic and organosilicon derivatives of hydrazine is demon

APA, Harvard, Vancouver, ISO, and other styles

10

Sepsey Für, Csilla, György Keglevich, and Hedvig Bölcskei. "Unexpected Formation of 4-aryl-1-(Propane-2-ylidenehydrazono)-2,3-diazaspiro[5.5]undec-3-ene by the Reaction of Pyridazinethiones Derivatives with Hydrazine." Molbank 2021, no. 3 (2021): M1243. http://dx.doi.org/10.3390/m1243.

Full text

Abstract:

After making a new series of spiro[cycloalkane]pyridazinones with high Fsp3 character available, the new target was to synthesize derivatives comprising nitrogen-containing heterocycles, such as triazolo or tetrazolo rings. The corresponding thioxo derivatives (1a,b) seemed to be good starting materials for the synthesis of tetrazolo derivatives. The reaction of the pyridazinethiones (1a,b) with hydrazine surprisingly resulted in Schiff bases (3a,b) deriving from the reaction of hydrazones (2a,b) with acetone.

APA, Harvard, Vancouver, ISO, and other styles

11

Gad, Emad M., Mohamed S. Nafie, Elsayed H. Eltamany, Magdy S. A. G. Hammad, Assem Barakat, and Ahmed T. A. Boraei. "Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation." Molecules 25, no. 11 (2020): 2523. http://dx.doi.org/10.3390/molecules25112523.

Full text

Abstract:

A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1. An interesting cyclization was obtained when the amino-ester 1 reacted with ethyl isothiocyanate to give the benzo[4,5]thieno[2,3-d][1,3]thiazin-4-one 3. Acylation of the amino-ester 1 with chloroacetyl chloride in DCM and Et3N afforded the acylated ester 4. The amino-ester 1 was cyclized to benzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one 8, which was reacted with some alkylating agents leading to alkylation at nitrogen 9–13. Hydrazide 14 was utilized as a synthon for the

APA, Harvard, Vancouver, ISO, and other styles

12

Garcia-Ramos, Yesica, Caroline Proulx, and William D. Lubell. "Synthesis of hydrazine and azapeptide derivatives by alkylation of carbazates and semicarbazones." Canadian Journal of Chemistry 90, no. 11 (2012): 985–93. http://dx.doi.org/10.1139/v2012-070.

Full text

Abstract:

Hydrazine and azapeptide analogs were synthesized effectively by alkylation of alkylidene carbazates and semicarbazones. In comparisons of benzylidene, benzhydrylidene, and fluorenylidene tert-butyl carbazates in alkylations using bases of different pKb character, superior conversion was obtained using the fluorenone derivative. Mild alkylation conditions were found employing Et4NOH as base and used to convert fluorenylidene tert-butyl carbazate into 13 different protected hydrazines. Moreover, racemization was avoided during alkylation of fluorenylidene semicarbazide in the synthesis of aza-p

APA, Harvard, Vancouver, ISO, and other styles

13

Zaki, Remon M., Adel M. Kamal El-Dean, Shaban M. Radwan, and Ahmed F. Saber. "Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2-d] pyrimidines and related heterocycles." Heterocyclic Communications 25, no. 1 (2019): 39–46. http://dx.doi.org/10.1515/hc-2019-0004.

Full text

Abstract:

AbstractNew pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3-c]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon treatment with nitrogen nucleophiles to give the pyrimidinones 3a-c. Treatment of 3a with formaldehyde and with triethyl orthoformate afforded the respective tetracyclic derivatives 4 and 5. Condensation of the amino group in the o-aminocarbonitrile 1 with triethyl orthoformate followed by cycloaddition reaction with hydrazine led to the formation of py

APA, Harvard, Vancouver, ISO, and other styles

14

Chauhan, Pradeep S., Skye Brettell, Mulamreddy Ramakotaiah, et al. "Hydrazine derivative synthesis by trifluoroacetyl hydrazide alkylation." Canadian Journal of Chemistry 98, no. 9 (2020): 485–94. http://dx.doi.org/10.1139/cjc-2020-0052.

Full text

Abstract:

N′-Alkyl hydrazides were effectively synthesized by routes featuring installation, alkylation, and removal of a trifluoroacetyl group. A set of amino acid derived hydrazides were acylated using trifluoroacetic anhydride, and the resulting trifluoroacetyl hydrazides were alkylated with alcohols in Mitsunobu reactions and with alkyl halides under alkaline conditions. Removal of the trifluoroacetyl group was affected under reductive and hydrolytic conditions to provide the respective N′-alkyl hydrazides. This three-step process may be performed without isolation of intermediates to yield N′-alkyl

APA, Harvard, Vancouver, ISO, and other styles

15

Mishra, A. D. "Microwave-Induced Synthesis of Some Novel Fungicidal Pyrazole Derivatives." Journal of Nepal Chemical Society 30 (December 19, 2013): 138–42. http://dx.doi.org/10.3126/jncs.v30i0.9385.

Full text

Abstract:

A series of novel pyrazole derivatives have been synthesized from propanoyl hydrazine and aromatic aldehydes under microwave irradiations. The reaction leads to condensation in ethanolic solution to give corresponding hydrazones which undergo subsequent cyclisation to furnish pyrazole derivatives in presence of formic acid. The reaction rate is enhanced considerably by using microwaves with excellent yield as compared to conventional heating method. The reactions took 4-7 minutes for completion with 78-92% yield. All the synthesized pyrazole derivatives showed promising antifungal activities a

APA, Harvard, Vancouver, ISO, and other styles

16

Shaji, Neethu, Sandhya M J Nair, and Shaiju S Dharan. "Coumarin Hydrazide: Chemistry, Synthesis and Pharmacological Activities - A Review." International Journal of Research and Review 9, no. 12 (2022): 16–26. http://dx.doi.org/10.52403/ijrr.20221202.

Full text

Abstract:

Coumarins are heterocyclic compound with a benzopyrone structure. Coumarins are a large group of organic compounds found in several plants even in bacteria and fungi. The biological activities of coumarins and its derivatives includes anticoagulant, anticancer, antiulcer, antifungal, anti-HIV, antimicrobial, antiosteoporosis, antioxidant and anti- inflammatory activity. Hydrazide-hydrazone derivatives act as structural sub units in many pharmacologically active compounds including coumarins to give biological activities like antimicrobial, anticancer, antifungal, anti-inflammatory, antiviral,

APA, Harvard, Vancouver, ISO, and other styles

17

Moreno, Leydi, Jairo Quiroga, Rodrigo Abonia, Jonathan Ramírez-Prada, and Braulio Insuasty. "Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents." Molecules 23, no. 8 (2018): 1956. http://dx.doi.org/10.3390/molecules23081956.

Full text

Abstract:

A new series of 1,3,5-triazine-containing 2-pyrazoline derivatives (8–11)a–g was synthesized by cyclocondensation reactions of [(4,6-bis((2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amine]chalcones 7a–g with hydrazine hydrate and derivatives. Chalcones 7a–g were obtained by Claisen-Schmidt condensation between aromatic aldehydes and triazinic derivative 5, which was synthesized in high yield by a microwave-assisted reaction. Seventeen of the synthesized compounds were selected and tested by the US National Cancer Institute (NCI) for their anticancer activity against 58 different human tumor cell

APA, Harvard, Vancouver, ISO, and other styles

18

Rozentsveig, Igor B., Valentina S. Nikonova, Victor V. Manuilov, et al. "Heterocyclization of Bis(2-chloroprop-2-en-1-yl)sulfide in Hydrazine Hydrate–KOH: Synthesis of Thiophene and Pyrrole Derivatives." Molecules 27, no. 20 (2022): 6785. http://dx.doi.org/10.3390/molecules27206785.

Full text

Abstract:

The article is devoted to heterocyclization of bis(2-chloroprop-2-en-1-yl)sulfide which proceeds in hydrazine hydrate–alkali medium and leads to formation of thiophene and pyrrole derivatives: previously described 4,5,9,10-tetrahydrocycloocta[1,2-c;5,8-c’]dithiophene, as well as unknown hydrazone of 5-methylidene-3-methyldihydrothiophen-2-one and 1-amino-2-(propynylsulfanylpropenylsulfanyl)-3,5-dimethylpyrrole. Tentative mechanisms for the formation of the heterocyclic products are discussed. Obtained hydrazone of 5-methylidene-3-methyldihydrothiophen-2-one was used for the synthesis of a rang

APA, Harvard, Vancouver, ISO, and other styles

19

Popiołek, Łukasz. "Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones." International Journal of Molecular Sciences 22, no. 17 (2021): 9389. http://dx.doi.org/10.3390/ijms22179389.

Full text

Abstract:

Hydrazide–hydrazones possess a wide spectrum of bioactivity, including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antidepressant, antiviral, and antiprotozoal properties. This review is focused on the latest scientific reports regarding antibacterial, antimycobacterial, and antifungal activities of hydrazide–hydrazones published between 2017 and 2021. The molecules and their chemical structures presented in this article are the most active derivatives, with discussed activities having a hydrazide–hydrazone moiety as the main scaffold or as a side

APA, Harvard, Vancouver, ISO, and other styles

20

Zeid, Ibrahim, Ibrahim Ismail, Hamed Abd El-Bary, and Fathy Abdel-Aziem. "Reactions of Sultones with Hydrazine Derivatives." Liebigs Annalen der Chemie 1987, no. 5 (1987): 481–82. http://dx.doi.org/10.1002/jlac.198719870359.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Zou, Wei, Asish K. Sen, Walter A. Szarek та David B. MacLean. "Synthesis of O-α-D-Rhap-(1 → 3)-O-α-D-Rhap-(1 → 2)-O-α-D-Rhap-(1 → 12)-oxydodecanoyl-bovine serum albumin". Canadian Journal of Chemistry 71, № 12 (1993): 2194–200. http://dx.doi.org/10.1139/v93-275.

Full text

Abstract:

The title compound (19), a conjugate of a trisaccharide based upon the repeating trisaccharide of α-D-rhamnose, which comprises the polysaccharide portion of "A-band" lipopolysaccharide from a mutant (AK1401) of Pseudomonas aeruginosa, strain PAOl, with bovine serum albumin (BSA) was synthesized starting with methyl α-D-mannopyranoside. Suitably protected D-rhamnose derivatives, namely, ethyl 3,4-di-O-benzyl-1-thio-α-D-rhamnopyranoside (11) and 3-O-acetyl-2,4-di-O-benzyl-α-D-rhamnopyranosyl chloride (12), were used as the glycosyl acceptor and donor, respectively, in the synthesis of disacchar

APA, Harvard, Vancouver, ISO, and other styles

22

Ito, Motoki, Shigeo Sugiyama, Yui Hasegawa, Satomi Saito, Asami Onda, and Kazuhiro Higuchi. "Dirhodium(II)-Catalyzed Synthesis of N-(Arylsulfonyl)hydrazines by N–H Amination of Aliphatic Amines." Synlett 33, no. 04 (2022): 367–70. http://dx.doi.org/10.1055/s-0041-1737759.

Full text

Abstract:

AbstractThis study reports the development of Rh(II)-catalyzed N–N bond-forming reaction of amino acid derivatives or aliphatic amines to provide hydrazine derivatives through the combined use of Rh2(esp)2 and [(3,4-dimethoxyphenyl)sulfonylimino]-2,4,6-trimethylphenyliodinane (3,4-(MeO)2C6H3SO2N=IMes). This is the first report of N–H amination of aliphatic amines with metal–nitrene species.

APA, Harvard, Vancouver, ISO, and other styles

23

Amr, Abd El-Galil E., Alhussein A. Ibrahimd, Mohamed F. El-Shehry, Hanaa M. Hosni, Ahmed A. Fayed, and Elsayed A. Elsayed. "In Vitro and In Vivo Anti-Breast Cancer Activities of Some Newly Synthesized 5-(thiophen-2-yl)thieno-[2,3-d]pyrimidin-4-one Candidates." Molecules 24, no. 12 (2019): 2255. http://dx.doi.org/10.3390/molecules24122255.

Full text

Abstract:

In this study, some of new thiophenyl thienopyrimidinone derivatives 2–15 were prepared and tested as anti-cancer agents by using thiophenyl thieno[2,3-d]pyrimidinone derivative 2 as a starting material, which was prepared from cyclization of ethyl ester derivative 1 with formamide. Treatment of 2 with ethyl- chloroacetate gave thienopyrimidinone N-ethylacetate 3, which was reacted with hydrazine hydrate or anthranilic acid to afford acetohydrazide 4 and benzo[d][1,3]oxazin-4-one 5, respectively. Condensation of 4 with aromatic aldehydes or phenylisothiocyanate yielded Schiff base derivatives

APA, Harvard, Vancouver, ISO, and other styles

24

Elshaier, Yaseen A. M. M., Ashraf A. Aly, Mohamed Abdel-Aziz, et al. "Synthesis and Identification of New N,N-Disubstituted Thiourea, and Thiazolidinone Scaffolds Based on Quinolone Moiety as Urease Inhibitor." Molecules 27, no. 20 (2022): 7126. http://dx.doi.org/10.3390/molecules27207126.

Full text

Abstract:

Synthesis of thiazolidinone based on quinolone moiety was established starting from 4-hydroxyquinol-2-ones. The strategy started with the reaction of ethyl bromoacetate with 4-hydroxyquinoline to give the corresponding ethyl oxoquinolinyl acetates, which reacted with hydrazine hydrate to afford the hydrazide derivatives. Subsequently, hydrazides reacted with isothiocyanate derivatives to give the corresponding N,N-disubstituted thioureas. Finally, on subjecting the N,N-disubstituted thioureas with dialkyl acetylenedicarboxylates, cyclization occurred, and thiazolidinone derivatives were obtain

APA, Harvard, Vancouver, ISO, and other styles

25

Filimonov, Valeriy O., Alexandra I. Topchiy, Vladimir G. Ilkin, Tetyana V. Beryozkina, and Vasiliy A. Bakulev. "Cyanothioacetamides as a synthetic platform for the synthesis of aminopyrazole derivatives." Beilstein Journal of Organic Chemistry 19 (August 8, 2023): 1191–97. http://dx.doi.org/10.3762/bjoc.19.87.

Full text

Abstract:

It was shown that the reaction of 2-cyanothioacetamides with hydrazine involves both cyano- and thioamide groups, and 3,5-diaminopyrazoles are formed. In the reaction of 2-cyano-3-(dimethylamino)-N,N-dimethylprop-2-enethioamides with hydrazine and its derivatives, the interaction proceeds with the participation of cyano- and enamine groups, not affecting the thiocarbamoyl group, and leads to the formation of 4-thiocarbamoylpyrazoles. A synthesis method has been developed and a series of 1-substituted-4-thiocarbamoyl pyrazoles has been thus synthesized. The structure of the reaction products wa

APA, Harvard, Vancouver, ISO, and other styles

26

Abu Ali, Ola A., Hosam A. Saad, and Bodor M. A. Al Malki. "Synthesis of Some New Folic Acid-Based Heterocycles of Anticipated Biological Activity." Molecules 26, no. 2 (2021): 368. http://dx.doi.org/10.3390/molecules26020368.

Full text

Abstract:

To date, no fused heterocycles have been formed on folic acid molecules; for this reason, and others, our target is to synthesize new derivatives of folic acid as isolated or fused systems. Folic acid 1 reacted with ethyl pyruvate, triethyl orthoformate, ethyl chloroformate, thioformic acid hydrazide, and aldehydes to give new derivatives of folic acid 2–6a,b. Moreover, It reacted with benzylidene malononitrile, acetylacetone, ninhydrin, ethyl acetoacetate, ethyl cyanoacetate, and ethyl chloroacetate to give the pteridine fused systems 10–15, respectively. Ethoxycarbonylamino derivate 5 reacte

APA, Harvard, Vancouver, ISO, and other styles

27

Tangeti, Venkata S., Kattaru R. Babu, Dasari Vasundhara, K. V. V. V. Satyanarayana, Himabindu Mylapalli, and Kaja S. P. Kumar. "One Pot Synthesis of Novel Substituted 2',4'-Dihydrospiro[chroman-2,3'-pyrazol]-4- one Derivatives." Current Organic Synthesis 15, no. 2 (2018): 267–74. http://dx.doi.org/10.2174/1570179414666171011161836.

Full text

Abstract:

Aim and Objective: In the work, we have successfully presented a synthetic route for the synthesis of novel 2',4'-dihydrospiro[chroman-2,3'-pyrazol]-4-one derivatives via one pot multicomponent approach. Materials and Method: Substituted 2',4'-dihydrospiro[chroman-2,3'-pyrazol]-4-one were prepared through cascade three-component condensation of ortho-hydroxyacetophenone, β-ketoester, hydrazine in the presence of pyrrolidine as a catalyst under ethanol reflux conditions. Results: A series of novel 2',4'-dihydrospiro[chroman-2,3'-pyrazol]-4-one have been synthesized through a facile strategy. Th

APA, Harvard, Vancouver, ISO, and other styles

28

Kurosu, Michio, Prabagaran Narayanasamy, and Dean C. Crick. "High-Throughput Synthesis of Substituted Hydrazine Derivatives." HETEROCYCLES 73, no. 1 (2007): 169. http://dx.doi.org/10.3987/com-07-s(u)14.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Kalinin, A. V., E. T. Apasov, Yu A. Strelenko, S. L. Ioffe, and V. A. Tartakovskii. "Formation of nitrohydrazones by acidic nitration of organic hydrazine derivatives." Russian Chemical Bulletin 42, no. 4 (1993): 700–703. http://dx.doi.org/10.1007/bf00704006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Bordei Telehoiu, Alexandra T., Diana C. Nuță, Miron T. Căproiu, et al. "Design, Synthesis and In Vitro Characterization of Novel Antimicrobial Agents Based on 6-Chloro-9H-carbazol Derivatives and 1,3,4-Oxadiazole Scaffolds." Molecules 25, no. 2 (2020): 266. http://dx.doi.org/10.3390/molecules25020266.

Full text

Abstract:

In this paper, we aimed to exploit and combine in the same molecule the carbazole and the 1,3,4-oxadiazole pharmacophores, to obtain novel carprofen derivatives, by using two synthesis pathways. For the first route, the following steps have been followed: (i) (RS)-2-(6-chloro-9H-carbazol-2-yl)propanonic acid (carprofen) treatment with methanol, yielding methyl (RS)-2-(6-chloro-9H-carbazol-2-yl)propanoate; (ii) the resulted methylic ester was converted to (RS)-2-(6-chloro-9H-carbazol-2-yl)propane hydrazide (carprofen hydrazide) by treatment with hydrazine hydrate; (iii) reaction of the hydrazid

APA, Harvard, Vancouver, ISO, and other styles

31

Dinesh, Bhambi, K. Sain Devendra, K. Salvi Vijay, Sharma Chirag, and L. Talesara G. "Synthesis and pharmacological studies on some phthalimidoxy substituted quinoline derivatives." Journal of Indian Chemical Society Vol. 86, Oct 2009 (2009): 1072–78. https://doi.org/10.5281/zenodo.5820506.

Full text

Abstract:

Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur-313 001, Rajasthan, India <em>E-mail</em> : gtalesara@yahoo.com <em>Manuscript received 30 September 2008, revised 1 April 2009, accepted 26 June 2009</em> Synthesis of novel <em>N'</em>-[2-(4-substitutedphenyi)-3-<em>N</em>-ethoxyphthalimido-5-oxoimidazolidene-1-yl]-2-(quinoline-8- yloxy)acetamide derivatives (6a-e) with potential biological activities were carried out by adopting the reaction scheme given below. Compound ethyl-(quinoline-8-yloxy)acetate (2) was synthesized by renu

APA, Harvard, Vancouver, ISO, and other styles

32

Thorat, Bapu R., Deepa Rani, Ramesh S. Yamgar, and Suraj N. Mali. "Synthesis, Spectroscopic, In-vitro and Computational Analysis of Hydrazones as Potential Antituberculosis Agents: (Part-I)." Combinatorial Chemistry & High Throughput Screening 23, no. 5 (2020): 392–401. http://dx.doi.org/10.2174/1386207323999200325125858.

Full text

Abstract:

Background: Since the last few decades, the healthcare sector is facing the problem of the development of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) infections all over the world. Regardless of the current healthcare progress for the treatment of mycobacterial infections, we are still unable to control addition of every year 9 million new cases of tuberculosis (TB). Objective: We had an objective to synthesize some novel hydrazones, which were further subjected to characterization, Photoluminescence study, in vitro anti-mycobacterium testing and in silico

APA, Harvard, Vancouver, ISO, and other styles

33

Murugesh, Nithya, Ramasamy Karvembu, and Seenuvasan Vedachalam. "The base-induced regioselective radical arylation of 3-aminochromone with aryl hydrazine." Organic & Biomolecular Chemistry 18, no. 39 (2020): 7884–91. http://dx.doi.org/10.1039/d0ob01689f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Zanatta, Nilo, Mateus Mittersteiner, Estefania C. Aquino, et al. "Synthesis of Methylene-Bridged Trifluoromethyl Azoles Using 5-(1,2,3-Triazol-1-yl)enones." Synthesis 54, no. 02 (2021): 439–50. http://dx.doi.org/10.1055/s-0040-1719837.

Full text

Abstract:

AbstractA protocol for synthesizing triazole-containing pyrazolines and pyrazoles selectively using trifluoromethylated 5-(1,2,3-triazol-1-yl)enones as starting materials, is reported. The selectivity of the reaction was controlled by the nature of the hydrazine or derivative used: free hydrazines furnished the 1,5-regiosiomer exclusively in yields up to 98%, whereas protected hydrazines provided the 1,3-regioisomer in yields up to 77%. To demonstrate the synthetic versatility of the triazole-based enone, reactions with other unsymmetrical dinucleophiles (hydroxylamine hydrochloride and S-meth

APA, Harvard, Vancouver, ISO, and other styles

35

Ilisson, Mihkel, Kristjan Tomson, Tarmo Tamm, and Uno Mäeorg. "Carbon–carbon double bond isomerization in heterocyclic hydrazine derivatives." Chemistry of Heterocyclic Compounds 54, no. 5 (2018): 572–75. http://dx.doi.org/10.1007/s10593-018-2308-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

S., Guru, Yadav R., Srivastava Soumya, K. Srivastava S., and D. Srivastava S. "Synthesis of some new N1-[(2-oxo-3-chloro-4-aryl-azitidin)-(acetyl amino)]-indole derivatives and their pharmacological activity." Journal of Indian Chemical Society Vol. 83, Dec 2006 (2006): 1236–124. https://doi.org/10.5281/zenodo.5834026.

Full text

Abstract:

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India <em>E-mail </em>: professorsks@rediffmail.com <em>Manuscript received 17 March 2006, revised 25 July 2006, accepted 7 September 2006</em> Indole on reaction with chloroacetyl chloride afforded N<sup>1</sup>-(1-chloro acetyl)-indole which was renuxed with hydrazine hydrate to give <em>N</em><sup>1</sup>-[(1-hydrazino)acetyl]-indole. The hydrazino derivative of indole was further treated with various substituted aromatic carbonyls to get <em>N</em><sup>1</sup>-[(benzyl

APA, Harvard, Vancouver, ISO, and other styles

37

Al-Rasheed, Hessa H., Sarah A. AL-khamis, Assem Barakat, Ayman El-Faham, Matti Haukka, and Saied M. Soliman. "Synthesis and Characterizations of Novel Isatin-s-Triazine Hydrazone Derivatives; X-ray Structure, Hirshfeld Analysis and DFT Calculations." Crystals 13, no. 2 (2023): 305. http://dx.doi.org/10.3390/cryst13020305.

Full text

Abstract:

A novel series of isatin-s-triazine hydrazone derivatives has been synthesized and reported herein. The synthetic methodology involved the reaction of s-triazine hydrazine precursors with isatin derivatives in the presence of CH3COOH as a catalyst and EtOH as solvent to afford the corresponding target products 6a-e in high yields and purities. The characterization data obtained from elemental analysis, FT-IR, NMR (1H- and 13C-) were in full agreement with the expected structures. Furthermore, an X-ray single crystal diffraction study of one of the target s-triazine hydrazone derivatives, 6c co

APA, Harvard, Vancouver, ISO, and other styles

38

H., Raveendranatha Reddy, Aggile Kadirappa, and Subashini R. "Synthesis of N-acetyl pyrazole and its analogues." Journal of Indian Chemical Society Vol. 92, Jun 2015 (2015): 933–36. https://doi.org/10.5281/zenodo.5673967.

Full text

Abstract:

Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632 014, Tamilnadu, India <em>E-mail</em> : subashinir@vit.ac.in Chalcones have been very attractive starting compounds in organic chemistry, as they are easy to synthesize with large variability. Chalcones are synthesized by Claisen-Schmidt condensation, which involves cross aldol condensation of suitable aldehydes and ketones by base catalysed or acid catalysed reactions followed by dehydration. So our aim is to construct novel <em>N</em>-acetyl pyrazole derivatives 4,5-dihydropyrazole were synthesized starting

APA, Harvard, Vancouver, ISO, and other styles

39

Grošelj, Uroš, David Bevk, Renata Jakše, et al. "Cyclocondensations of (+)-camphor derived enaminones with hydrazine derivatives." Tetrahedron 61, no. 16 (2005): 3991–98. http://dx.doi.org/10.1016/j.tet.2005.02.048.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Moldovan, Zaharie, Ovidiu Garlea, Teodora Panea, Alina Pop, Daniela Zinveliu, and Lucia Bodochi. "The mass spectral analysis of several hydrazine derivatives." Rapid Communications in Mass Spectrometry 12, no. 19 (1998): 1313–18. http://dx.doi.org/10.1002/(sici)1097-0231(19981015)12:19<1313::aid-rcm331>3.0.co;2-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Abdelmoniem, Amr M., Mohamed H. Elnagdi, Mohamed S. Elsehemy, Hesham R. El-Seedi, and Ismail A. Abdelhamid. "Synthesis, Chemistry and Utilities of Diaminoazoles with Special Reference to 3,5-diaminopyrazoles." Current Organic Synthesis 15, no. 4 (2018): 487–514. http://dx.doi.org/10.2174/1570179415666180403120140.

Full text

Abstract:

Background: Although the chemistry of heteroaromatic monoamino azoles has been surveyed more than once in the last decade, the chemistry of the di- and triaminoazoles has not been reviewed. In this article we will survey the synthesis, chemistry and utility of the diaminoazoles. In this review, the chemistry of the diaminoazoles as well as their most important utilities will be surveyed. Objective: The review focuses on recent progress in diaminoazoles (i.e. diaminopyrazoles, diaminoimidazoles, diaminotriazoles and diaminothiazole) with especial references to diaminopyrazoles. The synthesis as

APA, Harvard, Vancouver, ISO, and other styles

42

Breen, Jessica R., Graham Sandford, Dmitrii S. Yufit, Judith A. K. Howard, Jonathan Fray, and Bhairavi Patel. "Continuous gas/liquid–liquid/liquid flow synthesis of 4-fluoropyrazole derivatives by selective direct fluorination." Beilstein Journal of Organic Chemistry 7 (August 2, 2011): 1048–54. http://dx.doi.org/10.3762/bjoc.7.120.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Jiang, Gan, Yang Lin, Mingzhong Cai, and Hong Zhao. "Recyclable Heterogeneous Copper(II)-Catalyzed Oxidative Cyclization of 2-Pyridine Ketone Hydrazones Towards [1,2,3]Triazolo[1,5-a]pyridines." Synthesis 51, no. 23 (2019): 4487–97. http://dx.doi.org/10.1055/s-0037-1610726.

Full text

Abstract:

The heterogeneous copper(II)-catalyzed oxidative cyclization of 2-pyridine ketone hydrazones was achieved in ethyl acetate at room temperature in the presence of an MCM-41-anchored bidentate 2-aminoethylamino copper(II) catalyst [MCM-41-2N-Cu(OAc)2], in the presence of air as the oxidant, yielding a wide variety of [1,2,3]triazolo[1,5-a]pyridines in mostly good to high yields. The present method was also applied to the direct one-pot synthesis of [1,2,3]triazolo[1,5-a]pyridines from 2-acylpyridine derivatives and hydrazine monohydrate. Importantly, this supported copper(II) catalyst could be c

APA, Harvard, Vancouver, ISO, and other styles

44

Sepsey Für, Csilla Sepsey, Gergő Riszter, Áron SzigetvárI, et al. "Novel Ring Systems: Spiro[Cycloalkane] Derivatives of Triazolo- and Tetrazolo-Pyridazines." Molecules 26, no. 8 (2021): 2140. http://dx.doi.org/10.3390/molecules26082140.

Full text

Abstract:

In orderto synthesize new pyridazine derivatives anellated with different nitrogen heterocyclic moieties, spiro[cycloalkane]pyridazinones were transformed into the corresponding thioxo derivatives via a reaction with phosphorus pentasulfide. The reaction of the formed 2,3-diazaspiro[5.5] undec-3-ene-1-thiones with hydrazine provided the corresponding 1-hydrazono-2,3-diazaspiro[5.5] undec-3-ene, whose diazotization led to the desired spiro[cyclohexane-1,8′-tetrazolo[1,5-b]pyridazines. The reaction of dihydropyridazinethiones with benzhydrazide afforded the corresponding 7H-spiro[[1,2,4]triazolo

APA, Harvard, Vancouver, ISO, and other styles

45

Sonawane, R., and M. A. Sagare. "Design, Synthesis and Evaluation of Some Substituted Triazole Phenyl Methanones from Substituted Anilines." Asian Journal of Organic & Medicinal Chemistry 7, no. 4 (2023): 295–98. http://dx.doi.org/10.14233/ajomc.2022.ajomc-p405.

Full text

Abstract:

Triazoles, a five-membered ring structure and three nitrogen atoms, are regarded as important building blocks for the synthesis of numerous organic compounds. Triazoles and their derivatives have received considerable attention over the past decade due to their chemotherapeutic value. It’s been thought to be a functional core that exhibits most varieties of biological activity mainly antibiotics, antimicrobials and antifungals. In present work, a series of novel substituted triazole phenylmethanones were synthesized using Claisen-Schmidt condensation reaction of 1-(5-methyl-1-(substituted phen

APA, Harvard, Vancouver, ISO, and other styles

46

Mironovich, L. M. "Reactions of 4-nitroso-1,2,4-triazine with derivatives of hydrazine." Chemistry of Heterocyclic Compounds 32, no. 10 (1996): 1224–26. http://dx.doi.org/10.1007/bf01169238.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Sunil, S. Choudhare Gopinath S. Khansole and Vijay N. Bhosale*. "SYNTHESIS OF PHENYL 1H-INDAZOLO [1,2-b] PHTHALAZINE TRIONE DERIVATIVES WITH THEIR BIOLOGICAL EVALUATION." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4272–79. https://doi.org/10.5281/zenodo.1095543.

Full text

Abstract:

Heterocyclic compounds are the most global moieties in chemical compounds which exhibit wide spectrum of pharmacological activities. Multicomponent reactions are important tool in the hands of organic chemist’s,researcher. Since they offer improved atom economy for construction of complex molecules over the stepwise liner convergent synthesis. A simple, efficient and green protocol has been developed for the synthesis phenyl 1H-Indazolo [1,2-b] Phthalazine trione derivatives from a one pot four componant condensation of Phthalic anhydride, Hydrazine hydrate, Dimedone and different substi

APA, Harvard, Vancouver, ISO, and other styles

48

Bredihhin, Aleksei, and Uno Mäeorg. "Use of Polyanions for Alkylation of Hydrazine Derivatives." Organic Letters 9, no. 24 (2007): 4975–77. http://dx.doi.org/10.1021/ol702234s.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Bredihhin, Aleksei, Ulrich M. Groth, and Uno Mäeorg. "Efficient Methodology for Selective Alkylation of Hydrazine Derivatives." Organic Letters 9, no. 6 (2007): 1097–99. http://dx.doi.org/10.1021/ol070026w.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

KushalNath Mishra, Shambaditya Goswami, Kumudhavalli M.V, et al. "Hydrazones and their metal complexes: A short review on their biological potentia." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1440–47. http://dx.doi.org/10.26452/ijrps.v11ispl4.4319.

Full text

Abstract:

Hydrazones belong to complexes are beneficial in different fields for their essential role in the development of a range of stable complexes in the coordination chemistry. Different researchers have reported the various medicinal properties of hydrazones. Hydrazone and its metal complexes are useful for the detection of some organic components from pharmaceutical formulations. These metallic compounds act as a catalyst for conducting various chemical reactions and help in making different chemical complexes that are effective against bacteria, fungi, and many other microbes. Aromatic hydrazone

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!