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Dissertations / Theses on the topic 'Organofluorine chemistry'

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1

Sandford, Graham. "Some amine hydrofluorides and amines in organofluorine chemistry." Thesis, Durham University, 1991. http://etheses.dur.ac.uk/6209/.

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2

Andrew, Rebecca Jane. "Trifluoremethylated enaminoketones : an entry point to organofluorine chemistry." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243099.

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3

Fuss, Robert W. "New routes to novel organofluorine compounds." Thesis, Durham University, 1989. http://etheses.dur.ac.uk/6504/.

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Use of the carbon hydrogen bond as a functional group in free radical addition reactions to fluorinated olefins has been studied. Using cyclic ethers a detailed investigation of the products obtained revealed that not only carbon hydrogen bonds a to oxygen but also the β and γ carbon hydrogen bonds reacted. Employing hydrocarbons, clean free radical addition reactions initiated by either γ rays or peroxides were observed. Whereas aliphatic hydrocarbons gave reasonable yields, cyclic hydrocarbons gave nearly complete conversions. Some modifications of polyethylene using fluorinated olefins and
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4

Patterson, Richard. "Novel organofluorine chemistry : nucleophilic fluorinating agents and potential anticancer compounds." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/55525/.

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This thesis covers work investigating the effects of fluorine incorporation on the structure, biological activity, and NMR properties of anticancer chalcones as well as novel methods for the inclusion of fluorinated moieties into organic compounds. The first chapter looks at the use of silanes as carriers of small fluorinated nucleophiles which can be activated by fluoride anion catalysis to deliver such nucleophiles to organic electrophiles such as aldehydes. The synthesis of a group of such silanes and an assessment of their reactivity towards aromatic aldehydes is described. The second and
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5

Schueler, Martin. "The vicinal difluoro motif in organic chemistry : the synthesis and behaviour of compounds derived from 2,3-diflurosuccinic acids." Thesis, University of St Andrews, 2006. http://hdl.handle.net/10023/2632.

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The following work describes the synthesis of compounds carrying a vicinal difluoro motif and the evaluation of this structural element to influence the conformation of organic molecules. The synthesis of erythro and threo 1,2-difluoro-1,2-diphenylethane was achieved by bromofluorination and subsequent halogen exchange from stilbene. Oxidative degradation of the phenyl rings allowed to access erythro and threo 2,3- difluorosuccinic acids and a variety of derivatives thereof. The conformations of these compounds were investigated by means of X-ray analysis and NMR spectroscopy. Conformational a
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6

Beaumont, Andrew J. "A study of some selective nucleophilic fluorination reactions." Thesis, University of York, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306248.

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7

Gooseman, Natalie. "The influence of the C-N⁺------F-C charge dipole interaction in fluoro organic chemistry /." St Andrews, 2008. http://hdl.handle.net/10023/695.

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8

Giffin, Kaitlyn Anne. "Selective C-F and Ni-C Bond Activation of Fluoronickelacycles as a Function of Ancillary Ligands." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36619.

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The development of new unconventional routes to small functionalized fluorocarbons (FCs) continues to be an attractive target due to the high utility of FCs in a broad range of applications, including their use as refrigerants, solvents, and surfactants. With the phasing out of hydrofluoroalkanes as refrigerants, there is a growing interest in the synthesis of new hydrofluoroolefins (HFOs), which are known to have significantly reduced global warming potential relative to hydrofluoroalkanes. Currently, energy-intensive conditions and toxic starting materials are typically necessary for their s
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9

Mears, Paul. "Approaches towards the synthesis of the 20-deoxybryostatins and their 20,20-difluorinated analogues." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/approaches-towards-the-synthesis-of-the-20deoxybryostatins-and-their-2020difluorinated-analogues(82de5040-e32f-45fb-9537-8a5eaed7c67b).html.

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This thesis describes approaches towards the synthesis of 20-deoxybryostatins and 20,20-difluorobryostatins. Towards the 20-deoxybryostatins, a route previously developed within the group was followed with a protecting group change designed to prevent problems encountered with a late-stage deprotection. To this end, (R)-pantolactone was transformed through to dimethyl (4S,6R,8R)-[4-(para-methoxybenzyloxy)-10-hydroxy-6,8-O-isopropylidine-3,3-dimethyl-2-one] phosphonate which was subsequently subjected to a Horner-Wadworth-Emmons condensation with (5R,E)-6-(4-methoxybenzyloxy)-5-triethylsilyloxy
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10

Li, Yuqi. "Synthesis of fluorinated drug scaffolds using SNAr substitution reactions." Thesis, Loughborough University, 2017. https://dspace.lboro.ac.uk/2134/27541.

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Fluorinated arenes are considered valuable in organic chemistry. They display different types of reactivity and physicochemical properties compared to their hydrogen analogues. In this project, our medicinal chemistry programme focused on developing rapidly accessible and modifiable heterocyclic scaffolds. Different classes of fluorinated heteroatom-containing organic compounds including benzothiophenes, (aza)phenoxazines and benzaldehyde phenylhydrazones were synthesised from highly fluorinated aromatic compounds with a diverse range of functional groups appropriate for medicinal chemistry de
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11

Moraux, Thomas. "Synthesis and evaluation of α-fluoro analogues of capsaicin and 2-(aminomethyl)piperidine derivatives". Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2094.

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Chapter 1 gives an overview of the fluorine chemistry field, from its early developments to recent applications in medicinal chemistry. The development of asymmetric electrophilic or nucleophilic installation of fluorine in organic molecules is highlighten. Chapter 2 of this thesis discusses the enantioselective synthesis of α-fluoroamides. The study is applied to the synthesis of fluoroenantiomers of the bioactive molecule capsaicin and short-chain analogues. The biological activity of these compounds is assayed with the TRPV1 receptor. Results show that enantioselective α-fluoroamides (R)-97
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12

Chan, K. K. Jason. "Identification and enzyme studies of rare amino acid biosynthesis from Streptomyces cattleya." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/4478.

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This thesis is focussed on the biosynthesis of three toxins: fluoroacetate, 4-fluoro-L-theronine and β-ethynyl-L-serine which are biosynthesised by the soil bacteria Streptomyces cattleya. The two fluorinated metabolites originate from a common biosynthetic pathway and the thesis describes studies carried out on an aldose-ketose isomerase enzyme of the pathway. The biosynthetic origin of β-ethynyl-L-serine is not known. A total synthesis of this acetylenic amino acid is descibed along with the development of a new analytical method for identifying the metabolite and for future isotope-labellin
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13

Doshi, Ami P. "Functionalized organoboron polymers and supramolecular structures of pentafluorophenylcopper." 2010. http://hdl.rutgers.edu/1782.2/rucore10002600001.ETD.000052185.

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14

Romanelli, Michael Dennis. "Molecular lanthanide fluorides photoluminescence from novel architectures /." 2010. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052146.

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15

"Silicon-Hydrogen (Si-H), Aryl-Fluorine (Aryl-F) and Carbon-Carbon (C-C) bond activations by Iridium Porphyrin complexes." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074836.

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*Please refer to dissertation for diagrams.<br>Part I describes the silicon-hydrogen bond activation (SiHA) of silanes with both electron-deficient iridium porphyrin carbonyl chloride (Ir(ttp)Cl(CO)) and electron-rich iridium porphyrin methyl (Ir(ttp)Me) to give iridium(III) porphyrin silyls (Ir(ttp)SiR3). Firstly, Ir(ttp)SiR3 were synthesized in moderate to good yields conveniently from the reactions of Ir(ttp)Cl(CO) and Ir(ttp)Me with silanes, via SiHA in solvent-free conditions and non-polar solvents at 200&deg;C. Base facilitated the SiHA reaction even at lower temperature of 140&deg;C. Sp
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16

Dikundwar, Amol G. "Organic Fluorine in Crystal Engineering : Consequences on Molecular and Supramolecular Organization." Thesis, 2013. https://etd.iisc.ac.in/handle/2005/3352.

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The thesis entitled “Organic fluorine in crystal engineering: Consequences on molecular and supramolecular organization” consists of six chapters. The main theme of the thesis is to address the role of substituted fluorine atoms in altering the geometrical and electronic features in organic molecules and its subsequent consequences on crystal packing. The thesis is divided into three parts. Part I deals with compounds that are liquids under ambient conditions, crystal structures of which have been determined by the technique of in situ cryocrystallography. Part II demonstrates the utilizatio
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17

Dikundwar, Amol G. "Organic Fluorine in Crystal Engineering : Consequences on Molecular and Supramolecular Organization." Thesis, 2013. http://etd.iisc.ernet.in/2005/3352.

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The thesis entitled “Organic fluorine in crystal engineering: Consequences on molecular and supramolecular organization” consists of six chapters. The main theme of the thesis is to address the role of substituted fluorine atoms in altering the geometrical and electronic features in organic molecules and its subsequent consequences on crystal packing. The thesis is divided into three parts. Part I deals with compounds that are liquids under ambient conditions, crystal structures of which have been determined by the technique of in situ cryocrystallography. Part II demonstrates the utilization
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