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Journal articles on the topic 'Osteoarthritis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Abdelhameed, Abdelrahman Mohamed Galal, Said Mahmoud Mohamed Hani, and Ahmed Mohamed Mohamed Soliman. "Effects of Locally Delivered Morin Hydrate on Iodoacetate-induced Temporomandibular Joint Osteoarthritis in Rats." Brazilian Dental Science 23, no. 4 (2020): 11p. http://dx.doi.org/10.14295/bds.2020.v23i4.1904.

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Objectives: morin hydrate has been reported to possess many beneficial pharmacological potentialities including antioxidant and anti-osteoarthritic effects. The antiosteoarthritic properties of locally administrated morin have not been investigated. The objective of this study is to evaluate the locally delivered morin on the temporomandibular joint osteoarthritis in rat. Materials and methods: thirty young adult female Sprague Dawley rats were randomly arranged into three groups; control, osteoarthritis and osteoarthritis with morin. Both the iodoacetate for osteoarthritis induction and morin

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Yang, Tzi-Peng, Hsiao-Mei Chen, Chao-Chin Hu, et al. "Interaction of Osteoarthritis and BMI on Leptin Promoter Methylation in Taiwanese Adults." International Journal of Molecular Sciences 21, no. 1 (2019): 123. http://dx.doi.org/10.3390/ijms21010123.

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Leptin (LEP) regulates glucose metabolism and energy storage in the body. Osteoarthritis (OA) is associated with the upregulation of serum LEP. LEP promoter methylation is associated with obesity. So far, few studies have explored the association of BMI and OA with LEP methylation. We assessed the interaction between body mass index (BMI) and OA on LEP promoter methylation. Data of 1114 participants comprising 583 men and 558 women, aged 30–70 years were retrieved from the Taiwan Biobank Database (2008–2015). Osteoarthritis was self-reported and cases were those who reported having ever been c

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LI, H., X. Jiang, Y. Xiao, et al. "POS0329 CHONDROCYTE SUBPOPULATIONS AND CANONICAL PATHWAYS ASSOCIATED WITH HAND OSTEOARTHRITIS: DISCOVERY BY SINGLE-CELL TRANSCRIPTOMIC ANALYSIS AND VALIDATION BY TWO INDEPENDENT POPULATION-BASED STUDIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 410–11. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4327.

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BackgroundHand osteoarthritis is a common heterogeneous joint disorder with differences in aetiology and pathophysiology from the large weight-bearing knee or hip osteoarthritis.[1]-[3]Its pathophysiological mechanism remains largely unexplored, partially because of limited access to clinical sample tissues and lack of animal models.[2]To date, there is no known cure for hand osteoarthritis, indicating an urgent need for better understanding of the underlying mechanisms so that appropriate treatment strategies can be developed to target this disabling disease.ObjectivesWe aimed to identify han

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Myszka, Anna, Janusz Piontek, Jacek Tomczyk, and Marta Zalewska. "Osteoarthritis – a problematic skeletal trait in past human populations. Osteoarthritic changes vs. entheseal changes in the late medieval and early modern population form Łekno." Anthropological Review 83, no. 2 (2020): 143–61. http://dx.doi.org/10.2478/anre-2020-0011.

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AbstractAccording to medical knowledge, physical activity plays a role in osteoarthritic changes formation. The impact of occupation on osteoarthritic changes development in past human populations is not clear enough, causing problems with interpretation. The aim of the current study is to examine the relationship between osteoarthritis and entheseal changes. Skeletal material comes from the late medieval, early modern population from Łekno (Poland). The sample consists of 110 males and 56 females (adults only). Osteophytes, porosity and eburnation were analyzed in the shoulder, elbow, wrist,

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Ekeuku, Sophia Ogechi, Fairus Ahmad, and Kok-Yong Chin. "Changes of Grip Strength, Articular Cartilage and Subchondral Bone in Monoiodoacetate-Induced Osteoarthritis in Rats." Sains Malaysiana 51, no. 11 (2021): 3741–54. http://dx.doi.org/10.17576/jsm-2022-5111-18.

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Osteoarthritis is a degenerative disease affecting articular cartilage among the elderly. The intra-articular monoiodoacetate injection is one of the most widely used methods to induce osteoarthritis in animals. While the effects of monoiodoacetate on cartilage are well-characterized, its effects on subchondral bone remodeling are less studied. The purpose of this study was to determine the changes of the grip strength, articular cartilage structure and subchondral bone remodeling in monoiodoacetate-induced osteoarthritis in rats. Three-month-old male Wistar rats were assigned to normal contro

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Rahman, Kharman Khidhr, Shahen Ali Ahmed, Sarkawt Hamad Ali, and Khoshee Salh Hamed. "Detection and Severity Assessment of Temporomandibular Joint Osteoarthritic Changes in Patients with Temporomandibular Disorders Using CBCT." Erbil Dental Journal 7, no. 2 (2024): 132–43. https://doi.org/10.15218/edj.2024.15.

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Background and objectives: Osteoarthritis refers to a non-inflammatory condition often linked to aging. It involves the gradual breakdown of bone, cartilage, and surrounding soft tissues around the joints. The aim of this study is to detect osteoarthritic change in patients with temporomandibular disorder, to determine the severity of osteoarthritic changes, and to assess the relation of gender and age with the severity prevalence of temporomandibular joint osteoarthritis. Material and method: This retrospective, cross-sectional study analyzed 100 cone beam computed tomography (CBCT) scans of

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Mabey, Thomas, and Sittisak Honsawek. "Role of Vitamin D in Osteoarthritis: Molecular, Cellular, and Clinical Perspectives." International Journal of Endocrinology 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/383918.

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Osteoarthritis is a debilitating and degenerative disease which affects millions of people worldwide. The causes and mechanisms of osteoarthritis remain to be fully understood. Vitamin D has been hypothesised to play essential roles in a number of diseases including osteoarthritis. Many cell types within osteoarthritic joints appear to experience negative effects often at increased sensitivity to vitamin D. These findings contrast clinical research which has identified vitamin D deficiency to have a worryingly high prevalence among osteoarthritis patients. Randomised-controlled trial is consid

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Reeni.D, Bijilin, and George Joe Kumar. A. "A Study to Evaluate the Effectiveness of Aloe Vera Gel on Pain Perception among Patients with Osteoarthritis at Selected Communities in Kanyakumari District." Galore International Journal of Applied Sciences and Humanities 5, no. 4 (2021): 54–60. http://dx.doi.org/10.52403/gijash.20211009.

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Aim: to evaluate the effectiveness of Aloe Vera gel on pain perception among patients with osteoarthritis in selected communities at Kanyakumari district. Objectives: (i) To assess and compare the pre-test and post-test level of pain perception among patients with osteoarthritis in experimental and control group. (ii) To evaluate the effectiveness of Aloe Vera gel on level of pain perception among patients with osteoarthritis in experimental group. (iii) To find out the association between the post-test level of pain perception among patients with osteoarthritis in experimental group and contr

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Kriplani, Priyanka, Kumar Guarve, and Uttam Singh Baghel. "Novel Herbal Topical Patch Containing Curcumin and Arnica montana for the Treatment of Osteoarthritis." Current Rheumatology Reviews 16, no. 1 (2020): 43–60. http://dx.doi.org/10.2174/1573397115666190214164407.

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Background: Osteoarthritis (OA) ranks fifth among all forms of disability affecting 10% of the world population. Current treatments available are associated with multiple side effects and do not slow down the progression of the disease. Moreover, no such effective treatment is available to date in various systems of medicine to treat osteoarthritis. Curcumin and Arnica have shown evident clinical advances in the treatment of osteoarthritis. Objective: The aim of the present study was to design, optimize and characterize novel herbal transdermal patches of curcumin and Arnica montana using fact

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Huang, Chung-Cheng, Chen-Chang Lee, Ching-Jen Wang, et al. "Effect of Age-Related Cartilage Turnover on Serum C-Telopeptide of Collagen Type II and Osteocalcin Levels in Growing Rabbits with and without Surgically Induced Osteoarthritis." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/284784.

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This study aims to determine the effect of age-related cartilage turnover on the serum C-telopeptide of type II collagen (CTX-II) and osteocalcin (OC) levels in growing rabbits with and without surgically induced osteoarthritis. Twenty-four New Zealand male 3-month-old rabbits were randomized into three operated groups (n= 6 per group, with surgically induced osteroarthritis in the right knee; after blood sampling, the knees were harvested following euthanization at 2, 3, and 6 months after surgery) and a control group (n= 6, blood samples were obtained monthly between 3 and 15 months). Histom

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Al-Saadi, Hiba Murtadha, Kok-Yong Chin, Fairus Ahmad, et al. "Effects of Palm Tocotrienol-Rich Fraction Alone or in Combination with Glucosamine Sulphate on Grip Strength, Cartilage Structure and Joint Remodelling Markers in a Rat Model of Osteoarthritis." Applied Sciences 11, no. 18 (2021): 8577. http://dx.doi.org/10.3390/app11188577.

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Background: Osteoarthritis is a degenerative joint disease lacking disease-modifying therapeutic agents. This study aimed to compare the effects of palm tocotrienol-rich fraction (TRF), glucosamine sulphate, and both agents combined in rats with osteoarthritis induced by monosodium iodoacetate (MIA). Methods: Thirty adult male rats were randomized into normal control, and osteoarthritis groups were treated orally daily with vehicle, palm TRF (100 mg/kg), glucosamine sulphate (250 mg/kg), and both agents combined for 4 weeks. Body weight and grip strength were measured weekly. After being sacri

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Baker, Melissa E., Seungmee Lee, Michael Clinton, et al. "Investigation of MicroRNA Biomarkers in Equine Distal Interphalangeal Joint Osteoarthritis." International Journal of Molecular Sciences 23, no. 24 (2022): 15526. http://dx.doi.org/10.3390/ijms232415526.

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Osteoarthritis of the equine distal interphalangeal joint is a common cause of lameness. MicroRNAs from biofluids are promising biomarkers and therapeutic candidates. Synovial fluid samples from horses with mild and severe equine distal interphalangeal joint osteoarthritis were submitted for small RNA sequencing. The results demonstrated that miR-92a was downregulated in equine synovial fluid from horses with severe osteoarthritis and there was a significant increase in COMP, COL1A2, RUNX2 and SOX9 following miR-92a mimic treatment of equine chondrocytes in monolayer culture. This is the first

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Abd El-Karim, Somaia S., Ahlam H. Mahmoud, Asmaa K. Al-Mokaddem, et al. "Development of a New Benzofuran–Pyrazole–Pyridine-Based Molecule for the Management of Osteoarthritis." Molecules 28, no. 19 (2023): 6814. http://dx.doi.org/10.3390/molecules28196814.

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Osteoarthritis is a substantial burden for patients with the disease. The known medications for the disease target the mitigation of the disease’s symptoms. So, drug development for the management of osteoarthritis represents an important challenge in the medical field. This work is based on the development of a new benzofuran–pyrazole–pyridine-based compound 8 with potential anti-inflammatory and anti-osteoarthritis properties. Microanalytical and spectral data confirmed the chemical structure of compound 8. The biological assays indicated that compound 8 produces multifunctional activity as

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Klinck, Mary P., Beatriz P. Monteiro, Bertrand Lussier, et al. "Refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians: detection of naturally occurring osteoarthritis in laboratory cats." Journal of Feline Medicine and Surgery 20, no. 8 (2017): 728–40. http://dx.doi.org/10.1177/1098612x17730172.

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Objectives Feline osteoarthritis causes pain and disability. Detection and measurement is challenging, relying heavily on owner report. This study describes refinement of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians. Methods A video analysis of osteoarthritic (n = 6) and non-osteoarthritic (n = 4) cats facilitated expansion of scale items. Three successive therapeutic trials (using gabapentin, tramadol and oral transmucosal meloxicam spray) in laboratory cats with and without natural osteoarthritis (n = 12–20) permitted construct validation (assessments of diseas

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Waraich, Harsimrat S., Vikas Kumar, Ashok Goel, and Jatinder Singh. "A comparative study to assess the safety and efficacy of etoricoxib versus aceclofenac in osteoarthritis." International Journal of Basic & Clinical Pharmacology 7, no. 10 (2018): 2010. http://dx.doi.org/10.18203/2319-2003.ijbcp20183939.

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Background: Osteoarthritis (OA) is most common form of arthritis; also referred as degenerative joint disease or “wear and tear” arthritis. Cyclooxygenase-2 (COX-2) inhibitors are effective for pain and inflammation in OA and gained importance over conventional non-steroidal anti-inflammatory agents (NSAIDs), as causes significantly less toxicity, particularly, in gastrointestinal tract. The objective of the present research was to study the short-term comparative clinical efficacy of aceclofenac and etoricoxib in patients with osteoarthritis and to compare the safety profile of the two drugs

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Crane, Camille, Caleb Wagner, Stephen Wong, et al. "Glenohumeral Osteoarthritis: A Biological Advantage or a Missed Diagnosis?" Journal of Clinical Medicine 13, no. 8 (2024): 2341. http://dx.doi.org/10.3390/jcm13082341.

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(1) Background: Osteoarthritis is a degenerative joint disease that is commonly diagnosed in the aging population. Interestingly, the lower extremity joints have a higher published incidence of osteoarthritis than the upper extremity joints. Although much is known about the disease process, it remains unclear why some joints are more affected than others. (2) Methods: A comprehensive literature review was conducted utilizing the search engines PubMed, Google Scholar, and Elsevier from 2014 to 2024, directing our search to osteoarthritis of various joints, with the focus being on glenohumeral o

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Shorter, Emily, Roberto Avelar, Margarita Zachariou, et al. "Identifying Novel Osteoarthritis-Associated Genes in Human Cartilage Using a Systematic Meta-Analysis and a Multi-Source Integrated Network." International Journal of Molecular Sciences 23, no. 8 (2022): 4395. http://dx.doi.org/10.3390/ijms23084395.

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Osteoarthritis, the most common joint disorder, is characterised by deterioration of the articular cartilage. Many studies have identified potential therapeutic targets, yet no effective treatment has been determined. The aim of this study was to identify and rank osteoarthritis-associated genes and micro-RNAs to prioritise those most integral to the disease. A systematic meta-analysis of differentially expressed mRNA and micro-RNAs in human osteoarthritic cartilage was conducted. Ingenuity pathway analysis identified cellular senescence as an enriched pathway, confirmed by a significant overl

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ten Berg, Paul W. L., Erik Heeg, Simon D. Strackee, and Geert J. Streekstra. "Joint Space Narrowing in Patients With Pisotriquetral Osteoarthritis." HAND 12, no. 5 (2016): 490–92. http://dx.doi.org/10.1177/1558944716677542.

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Background: Patients with suspected pisotriquetral osteoarthritis may show joint space narrowing. However, the extent of joint space narrowing and its deviation from the joint space width (JSW) in normal anatomy is unknown. In this pathoanatomic study, we therefore compared the JSW in the pisotriquetral joint between osteoarthritic patient wrists and healthy wrists. Methods: We reviewed preoperative computed tomography (CT) scans of 8 wrists of patients with ulnar-sided wrist pain who underwent a pisiformectomy with confirmed pisotriquetral osteoarthritis at surgery. We also reviewed CT scans

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Gong, H. S., and K. J. Bae. "FRI0402 MAGNETIC RESONANCE IMAGING EVALUATION OF CARTILAGE EROSION AND LIGAMENT INTEGRITY IN EARLY STAGE THUMB CARPOMETACARPAL JOINT OSTEOARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 799.3–799. http://dx.doi.org/10.1136/annrheumdis-2020-eular.878.

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Background:Most of the studies on pathogenesis of thumb carpometacaral joint (CMCJ-1) osteoarthritis were from cadavers or patients with advanced osteoarthritis, therefore the findings may not reflect any early changes of cartilage wear and ligament condition.Objectives:We evaluated MRI to address where articular degeneration begins and which ligaments are most often involved in the early clinical stage CMCJ-1 osteoarthritis.Methods:We retrospectively analyzed MRI examinations of 26 patients with early clinical stage CMCJ-1 osteoarthritis without radiologic abnormality and 19 control patients

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Mölsä, S. H., J. T. Junnila, O. M. Laitinen-Vapaavuori, A. K. Hielm-Björkman, and H. K. Hyytiäinen. "Use of bathroom scales in measuring asymmetry of hindlimb static weight bearing in dogs with osteoarthritis." Veterinary and Comparative Orthopaedics and Traumatology 25, no. 05 (2012): 390–96. http://dx.doi.org/10.3415/vcot-11-09-0135.

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SummaryObjective: The study assessed the use and reliability of bathroom scales as an objective measurement tool, and setting a normal variance of static weight bearing between hindlimbs.Methods: Two groups of dogs were tested: a healthy control group (n = 21) and a group (n = 43) of dogs with confirmed osteoarthritis in at least one stifle joint, with or without hip joint osteoarthritis. Static weight bearing was evaluated manually and measured with two bathroom scales. An orthopaedic examination was done and dynamic weight bearing was measured using a force platform. Radiographs were taken t

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Van Ginckel, Ans, and Erik Witvrouw. "Acute Cartilage Loading Responses After an In Vivo Squatting Exercise in People With Doubtful to Mild Knee Osteoarthritis: A Case-Control Study." Physical Therapy 93, no. 8 (2013): 1049–60. http://dx.doi.org/10.2522/ptj.20120491.

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Background The effects of exercise on osteoarthritic cartilage remain elusive. Objective The objective of this study was to investigate the effect of dynamic in vivo squatting exercise on the magnitude and spatial pattern of acute cartilage responses in people with tibiofemoral osteoarthritis (ie, Kellgren-Lawrence grades 1 and 2). Design This investigation was a case-control study. Methods Eighteen people with radiographic signs of doubtful to mild medial tibiofemoral osteoarthritis were compared with 18 people who were middle-aged and healthy (controls). Three-dimensional magnetic resonance

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Hina, Peraha Wagan, Dr Suni Kumar, Muhammad Tahir Akram, Chaman Lal, and Dr Tanzeela Mujtaba. "Role of Joint Mobilization in Improving Function and Reducing Pain in Knee Osteoarthritis Patients." ACADEMIA International Journal for Social Sciences 4, no. 2 (2025): 1695–713. https://doi.org/10.63056/acad.004.02.0283.

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Knee osteoarthritis is a degenerative disease of articular cartilage and effect on joint mobility and balance. Mobilization is passive manual therapy which is perform by skill practitioner in order to reduce initial symptoms like pain, swelling, and improve range of motion and joint mobility. The current study investigated the outcomes of Mobilization in knee osteoarthritis patient.The objective of this study is to evaluate Outcomes of knee Mobilization in knee Osteoarthritis.A total of 100 subject were recruited for the study on the basis of inclusion and exclusion criteria after signing the

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Richter, Elisabeth, Christoph H. Lohmann, Francesco Dell’Accio, Claudia Goettsch, and Jessica Bertrand. "Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence." International Journal of Molecular Sciences 24, no. 15 (2023): 12343. http://dx.doi.org/10.3390/ijms241512343.

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Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage calcification, loss of articular cartilage, bone changes, pain, and disability. Cartilage calcification is one hallmark of OA and is predominantly caused by basic calcium crystals formed due to an imbalance of the pyrophosphate pathway. Sortilin is a transmembrane protein that contributes to vascular calcification in atherosclerosis by externalizing alkaline phosphatase (ALP)-containing vesicles. Calcification in atherosclerosis and osteoarthritis has been associated with cellular senescence. The aim of this st

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Durgesh, Gavande* Dr. Anjali wankhade Dr. Vivek Paithankar. "Anti-Osteoarthritis Potential of Fagonia Arabica in Formaldehyde Induced Osteoarthritis in Experimental Animal." International Journal of Pharmaceutical Sciences 3, no. 6 (2025): 1207–16. https://doi.org/10.5281/zenodo.15608509.

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Osteoarthritis (OA) is a degenerative joint disorder characterized by the progressive breakdown of articular cartilage, changes in subchondral bone, and inflammation of synovial structures. Fagonia arabica, a medicinal plant known for its anti-inflammatory and antioxidant properties, has been traditionally used to treat various ailments. This study aimed to evaluate the anti-osteoarthritic potential of the ethanolic extract of Fagonia arabica (EEFA) in a formaldehyde-induced OA rat model. Wistar rats were divided into five groups: control, formaldehyde-induced (0.1 ml), standard (diclofenac so

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Dnyaneshwar Mote, Sandip Mali, and Manasi Maurya. "Clinical Evaluation of Vedistry Shallaki + Tablets in the Management of Osteoarthritis." Journal of Ayurveda and Integrated Medical Sciences 10, no. 2 (2025): 54–62. https://doi.org/10.21760/jaims.10.2.9.

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Objective: To establish the efficacy and safety of Vedistry Shallaki + Tablet in the management of osteoarthritis (OA). Method: A randomized, double blind, active controlled, single center, clinical study was carried out in 300 osteoarthritic subjects to evaluate the efficacy and safety of Vedistry Shallaki + Tablet in relieving symptoms of moderate to mild OA. The efficacy and safety of Vedistry Shallaki + Tablet administration in a dose of 1 tablet twice daily for 90 days was directly compared with the selective COX-2 inhibitor, celecoxib given in a dose of 100 mg twice daily using total Wes

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Villagrán-Andrade, Karla Mariuxi, Carmen Núñez-Carro, Francisco J. Blanco, and María C. de Andrés. "Nutritional Epigenomics: Bioactive Dietary Compounds in the Epigenetic Regulation of Osteoarthritis." Pharmaceuticals 17, no. 9 (2024): 1148. http://dx.doi.org/10.3390/ph17091148.

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Nutritional epigenomics is exceptionally important because it describes the complex interactions among food compounds and epigenome modifications. Phytonutrients or bioactive compounds, which are secondary metabolites of plants, can protect against osteoarthritis by suppressing the expression of inflammatory and catabolic mediators, modulating epigenetic changes in DNA methylation, and the histone or chromatin remodelling of key inflammatory genes and noncoding RNAs. The combination of natural epigenetic modulators is crucial because of their additive and synergistic effects, safety and therap

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Cornelis, Frederique M. F., Silvia Monteagudo, Laura-An K. A. Guns, et al. "ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone." Science Translational Medicine 10, no. 458 (2018): eaar8426. http://dx.doi.org/10.1126/scitranslmed.aar8426.

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Osteoarthritis is the most common joint disorder with increasing global prevalence due to aging of the population. Current therapy is limited to symptom relief, yet there is no cure. Its multifactorial etiology includes oxidative stress and overproduction of reactive oxygen species, but the regulation of these processes in the joint is insufficiently understood. We report that ANP32A protects the cartilage against oxidative stress, preventing osteoarthritis development and disease progression. ANP32A is down-regulated in human and mouse osteoarthritic cartilage. Microarray profiling revealed t

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Sadique, Mo, Kshitendra Mohan Jaishwal, and Sapna Ratan Shah. "Assessing the Influence of Glucosamine Supplementation on Synovial Fluid Dynamics in Osteoarthritic Knee Joints." International Journal of Applied Sciences and Biotechnology 12, no. 2 (2024): 84–91. http://dx.doi.org/10.3126/ijasbt.v12i2.65009.

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Osteoarthritis (OA) is a prevalent joint disorder characterized by the degeneration of articular cartilage, leading to pain, stiffness, and impaired joint function. Synovial fluid plays a crucial role in maintaining joint health by providing lubrication, shock absorption, and nutrient supply to the articular cartilage. In Osteoarthritis, alterations in synovial fluid composition and flow dynamics contribute to disease progression and symptom severity. Glucosamine, a popular dietary supplement, is widely used for its purported benefits in managing Osteoarthritis symptoms and potentially slowing

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Waluyo, Yose, Sari Rajwani Artika, Insani Nanda Wahyuni, Andi Muh Aunul Khaliq Gunawan, and Ahmad Taufik Fadillah Zainal. "Efficacy of Prolotherapy for Osteoarthritis: A Systematic Review." Journal of Rehabilitation Medicine 55 (February 27, 2023): jrm00372. http://dx.doi.org/10.2340/jrm.v55.2572.

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Objective: Current treatments for osteoarthritis do not resolve the underlying cause. Dextrose prolotherapy is an alternative method that has been proposed for treatment of osteoarthritis, due to its ability to aid tissue regeneration, improve clinical manifestations, and repair damaged tissue structures, which are pathological conditions in osteoarthritis. The aim of this systematic review was to evaluate the efficacy of dextrose prolotherapy compared with other interventions in the management of osteoarthritis.Methods: Electronic databases PubMed, Google Scholar, Cochrane, and BioMed Central

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Swärd, Elin, Inger Nennesmo, and Maria Wilcke. "Structural Changes in the Posterior Interosseous Nerve from Patients with Wrist Osteoarthritis and Asymptomatic Controls." Journal of Wrist Surgery 9, no. 06 (2020): 481–86. http://dx.doi.org/10.1055/s-0040-1713655.

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Abstract Background Posttraumatic morphological changes have been described in the posterior interosseous nerve (PIN) after mild wrist trauma, and it has been suggested that posttraumatic nerve changes may contribute to wrist pain. PIN excision has shown to relieve pain in some patients with wrist osteoarthritis. However, is not known if PINs from osteoarthritic wrist have pathological features. Objective The aim of this study was to investigate whether PINs from osteoarthritic wrists show morphological changes that are not present in healthy wrists. Materials and Methods PINs resected from 15

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Moulishree Ramesh, Karthik Ganesh Mohanraj, and Don K R. "Association between osteoarthritis of knee joint with gender, diabetes and work related diseases in middle aged and old aged population - A survey." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (2020): 112–22. http://dx.doi.org/10.26452/ijrps.v11ispl3.2900.

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Osteoarthritis is a common musculoskeletal disorder where thinning of cartilage fibers occurs in the joints which causes stiffness, pain, and impairment. Diabetes is a metabolic disorder where the blood sugar level is not maintained properly at normal range. Knee joint osteoarthritis is one of the commonest arthritis. Age is said to be an essential risk factor for diabetes and arthritis. A well-structured set of self-evaluable questionnaires were circulated among the south Indian population. The data was collected by the survey planet link, the questions were verified by the institutional revi

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Shen, Pengfei, Bin Wang, Chong Zheng, and Zikang Xie. "Shao-Yang-Xi-Bi-Fang Inhibits Chondrocyte Injury and Inflammation in a Rat Model of Osteoarthritis." Current Topics in Nutraceutical Research 20, no. 2 (2021): 239–46. http://dx.doi.org/10.37290/ctnr2641-452x.20:239-246.

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In the present study, we have examined the protective role and mechanism of Shao-Yang-Xi-Bi-Fang on osteoarthritis induced chondrocyte injury. We observed (a) upregulation of the expression of miR-15a-5p that was positively associated with cell apoptosis and (b) downregulation of protein kinase B protein and mRNA expression in osteoarthritic tissues. Further studies showed that 3'-untranslated regions of the protein kinase B mRNA were the direct target of the miR-15a-5p. The downregulation of the miR-15a-5p led to upregulation of the protein kinase B and mammalian target of rapamycin expressio

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ten Berg, P. W. L., J. G. G. Dobbe, M. E. Brinkhorst, S. D. Strackee, and G. J. Streekstra. "Comparing radial styloid size between osteoarthritic and healthy wrists: a pathoanatomical three-dimensional study." Journal of Hand Surgery (European Volume) 42, no. 1 (2016): 63–70. http://dx.doi.org/10.1177/1753193416669261.

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Radial styloid pointing due to spur formation is considered an early sign of osteoarthritis, but is sometimes difficult to distinguish from normal anatomic variation. In this pathoanatomical study we used three-dimensional imaging techniques to evaluate quantitatively whether the styloid size is larger in wrists with scaphoid non-union than in healthy wrists. We compared these findings with duration of the non-union and with the scaphoid non-union advanced collapse classification, which was based on radiographic assessment of the general level of wrist osteoarthritis. In 31 patients, the injur

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Alvarez López, Alejandro. "Lateral Knee Osteoarthritis." Clinical Orthopaedics and Trauma Care 4, no. 1 (2022): 01–05. http://dx.doi.org/10.31579/2694-0248/017.

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Background: gonarthrosis is a common entity characterized by involvement of one or more compartments, of which the lateral one is the one with the lowest incidence in isolation. Aim: the aims of this research are too updated on the most important features on lateral knee osteoarthritis and look for updated bibliography on the subject. Methods: PubMed, Hinari, SciELO and Medline databases were searched for citations from August 1st 2021 to September 30th 2021 using the EndNote search manager and reference manager. Out of 312 articles, 44 selected citations were used in this review, being 42 of

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Jaiswal, Dhananjay Kumar. "Article on Osteoarthritis." Journal of Orthopedics & Bone Disorders 7, no. 3 (2023): 1–8. http://dx.doi.org/10.23880/jobd-16000245.

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Osteoarthritis, a prevalent and debilitating joint disorder, gradually erodes cartilage—the protective cushion between bones—leading to pain, stiffness, and reduced joint mobility, primarily in weight-bearing joints. While age, genetics, and joint injuries are key contributors, the symptoms, starting with minor discomfort, escalate to pronounced pain and limited movement. Timely diagnosis, involving patient history, exams, and imaging, is vital. Treatment entails pain management, physical therapy, lifestyle adjustments, and, in extreme cases, joint replacement surgery. Ongoing research offers

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Karwa, Pawan, Pooja Kamble, Surabhi Jarare, Addepalli V, Vaishali Undale, and Shubhangi Shelar. "Effect of Combination of Alcoholic Extract of Zingiber Officinale (AEZO) and Hydroalcoholic Extract of Brassica Oleracea (HAEBO) on Papain Induced Osteoarthritis in Wistar Rats." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 17, no. 5 (2024): 7589–95. https://doi.org/10.37285/ijpsn.2024.17.5.5.

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Background: The “degenerative joint disease” i.e. Osteoarthritis (OA) is very common nowadays, which affects generally the knee joints. Osteoarthritis occurs in all the synovial joints of the hand, spine, wrist, hip, knee, and ankles. While we are focusing on the current Indian scenario, it was found that the prevalence rate of osteoarthritis ranges from 22-39 percent. Overall, it often affects both males and females after the age of 45. It affects more than 500 million people globally. Age, weight, gender, joint damage, and heredity were additional risk factors for OA. Osteoarthritis causes p

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Takeshi Tokoshima, Kazunori Hase, Rui Gong, and Makoto Yoshida. "Non-Invasive Monitoring of Knee Osteoarthritis Severity Using Vibration Stimulation." Proceedings of Engineering and Technology Innovation 29 (February 10, 2025): 01–10. https://doi.org/10.46604/peti.2024.14079.

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This study aims to explore the application of vibration stimulation for the early detection and assessment of knee osteoarthritis severity, using a porcine knee joint. Accelerometers are attached to the femurs and tibias to measure vibratory responses under simulated osteoarthritic conditions. Frequency response functions are generated from the acceleration data and quantified using the root mean square deviation (RMSD) relative to baseline conditions. To ensure the reliability of the results, a coherence filter is applied, confirming significant differences across various stages of joint inju

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Wu, Jiaqi, Zhan Zhang, Xun Ma, and Xueyong Liu. "Advances in Research on the Regulatory Roles of lncRNAs in Osteoarthritic Cartilage." Biomolecules 13, no. 4 (2023): 580. http://dx.doi.org/10.3390/biom13040580.

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Osteoarthritis (OA) is the most common degenerative bone and joint disease that can lead to disability and severely affect the quality of life of patients. However, its etiology and pathogenesis remain unclear. It is currently believed that articular cartilage lesions are an important marker of the onset and development of osteoarthritis. Long noncoding RNAs (lncRNAs) are a class of multifunctional regulatory RNAs that are involved in various physiological functions. There are many differentially expressed lncRNAs between osteoarthritic and normal cartilage tissues that play multiple roles in

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Zrimšek, P., V. Kadunc Kos, J. Mrkun, and M. Kosec. "Diagnostic Value of MMP-2 and MMP-9 in Synovial Fluid for Identifying Osteoarthritis in the Distal Interphalangeal Joint in Horses." Acta Veterinaria Brno 76, no. 1 (2007): 87–95. http://dx.doi.org/10.2754/avb200776010087.

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Our aim was to examine the diagnostic potential of matrix metalloproteinases MMP-2 and MMP-9 for identifying osteoarthritis in the horse. Horses were divided into two groups - a positive group consisting of 28 horses with cartilage damage in the distal interphalangeal joint and a negative group of 17 control horses. Clinical examination of the horses included evaluation of lameness, flexion test, diagnostic nerve blocks, X-ray and arthroscopy. MMP-2 and MMP-9 were detected in synovial fluid using gelatin zymography. Monomers of MMP-2 and MMP-9 appeared not to be specific for osteoarthritis sin

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Li, C., Y. Ding, S. Li, S. Lin, Z. Wen, and Z. Ouyang. "TAK1 MEDIATES HMGB1-INDUCED MACROPHAGE ACTIVATION IN OSTEOARTHRITIS." Orthopaedic Proceedings 105-B, SUPP_7 (2023): 107. http://dx.doi.org/10.1302/1358-992x.2023.7.107.

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Osteoarthritis, the most common degenerative joint disease, significantly impairs life quality and labor capability of patients. Synovial inflammation, initiated by HMGB1 (High mobility group box 1)-induced activation of macrophage, precedes other pathological changes. As an upstream regulator of NF-κB (nuclear factor-kappa B) and MAPK (mitogen-activated protein kinase) signaling pathway, TAK1 (TGF-β activated kinase 1) participates in macrophage activation, while its function in osteoarthritis remains unveiled. This study aims to investigate the role of TAK1 in the pathogenesis of osteoarthri

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Shanmugasundaram, Saseendar, Ketansinh Solanki, Samudeeswari Saseendar, Vijay K. Chavada, and Riccardo D’Ambrosi. "Role of Doxycycline as an Osteoarthritis Disease-Modifying Drug." Journal of Clinical Medicine 12, no. 8 (2023): 2927. http://dx.doi.org/10.3390/jcm12082927.

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Doxycycline is a drug that has been proposed to modify osteoarthritis (OA) progression, in addition to its role as an antibiotic. However, available evidence thus far comprises sporadic reports, with no consensus on its benefits. Hence, this review attempts to analyze the evidence available thus far on the role of doxycycline as a disease-modifying osteoarthritis drug (DMOAD) in knee osteoarthritis. The earliest evidence of doxycycline in OA appeared in 1991 when doxycycline was found to inhibit the type XI collagenolytic activity of extracts from the human osteoarthritic cartilage, and gelati

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Welhaven, Hope D., Avery H. Welfley, Priyanka Brahmachary, et al. "Metabolomic Profiles and Pathways in Osteoarthritic Human Cartilage: A Comparative Analysis with Healthy Cartilage." Metabolites 14, no. 4 (2024): 183. http://dx.doi.org/10.3390/metabo14040183.

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Osteoarthritis (OA) is a chronic joint disease with heterogenous metabolic pathology. To gain insight into OA-related metabolism, metabolite extracts from healthy (n = 11) and end-stage osteoarthritic cartilage (n = 35) were analyzed using liquid chromatography–mass spectrometry metabolomic profiling. Specific metabolites and metabolic pathways, including lipid and amino acid pathways, were differentially regulated in osteoarthritis-derived and healthy cartilage. The detected alterations in amino acids and lipids highlighted key differences in bioenergetic resources, matrix homeostasis, and mi

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Hong, Junyi, Fusheng Ye, Binjia Yu, Junwei Gao, Feicheng Qi, and Wei Wang. "Identification of the specific microRNAs and competitive endogenous RNA mechanisms in osteoporosis." Journal of International Medical Research 48, no. 10 (2020): 030006052095472. http://dx.doi.org/10.1177/0300060520954722.

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Objective Osteoporosis and osteoarthritis are metabolic skeletal disorders. This study aimed to identify specific networks of competitive endogenous RNA (ceRNA) in osteoporosis that differ from those in osteoarthritis. Methods The dataset GSE74209 was downloaded from the Gene Expression Omnibus, and differentially expressed microRNAs (DEmiRNAs) in osteoporotic samples and osteoarthritic samples were identified. After predicting target genes and linked long noncoding (lnc)RNAs, ceRNA networks of DEmiRNAs were constructed. The nodes that overlapped between ceRNA networks and the Comparative Toxi

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Russo, Rosita, Valentina Vassallo, Antonietta Stellavato, et al. "Differential Secretome Profiling of Human Osteoarthritic Synoviocytes Treated with Biotechnological Unsulfated and Marine Sulfated Chondroitins." International Journal of Molecular Sciences 21, no. 11 (2020): 3746. http://dx.doi.org/10.3390/ijms21113746.

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Symptomatic slow-acting drugs (SYSADOA) are increasingly used as effective therapies for osteoarthritis, representing an attractive alternative to analgesics or non-steroidal anti-inflammatory drugs to relieve disease symptoms. Pharmaceutical preparations of chondroitin sulfate, derived from animal sources, alone or in combination with glucosamine sulfate, are widely recognized for their beneficial effect on osteoarthritis treatment. A growing interest has also been devoted to understanding the molecular mechanisms modulated by SYSADOA using -omic strategies, most of which rely on chondrocytes

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Song, Yingzhuo, Tao Zhang, Huiguang Cheng, et al. "Imidazolium-Based Ionic Liquid-Assisted Preparation of Nano-Spheres Loaded with Bio-Active Peptides to Decrease Inflammation in an Osteoarthritis Model: Ex Vivo Evaluations." Journal of Biomedical Nanotechnology 17, no. 5 (2021): 859–72. http://dx.doi.org/10.1166/jbn.2021.3069.

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Osteoarthritis is one of the most prevalent chronic diseases. Cartilage inflammation in osteoarthritis results from pain in articular joints. Anti-inflammatory drugs provide relief by hindering the production of pro-inflammatory cytokines and interleukin-6. Targeted delivery of anti-inflammatory drugs is very effective in the treatment of osteoarthritis. This approach reduces the usage of therapeutic drug dosages and unwanted side effects. Here, we fabricated a non-invasive and efficient targeted drug delivery system to reduce persistent inflammation in an osteoarthritis model. Temperature-sen

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Yadav, Gopal, Divesh Singh, and Abhinav Yadav. "Knee Varus as "Pre - Osteoarthritic Lesion" in Initiation and Progression of Knee Osteoarthritis in Perimenopausal Women." International Journal of Science and Research (IJSR) 13, no. 8 (2024): 712–16. http://dx.doi.org/10.21275/sr24809153454.

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BUSUIOC, Diana ALexandra, Cristina Elena HORHOGEA, and Dan DRUGOCIU. "UTILISATION OF ADIPOSE - DERIVED MESENCHYMAL STEM CELLS IN THE TREATMENT OF CANINE OSTEOARTHRITIS - CASE STUDY." Scientific Papers Journal VETERINARY SERIES 67, no. 2 (2024): 59–61. https://doi.org/10.61900/spjvs.2024.02.12.

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Adipose-derived mesenchymal stem cells (ADMSCs) have gained attention as a potential treatment for canine osteoarthritis due to their regenerative properties and ability to modulate inflammation. ADMSCs are harvested from adipose (fat) tissue, which is abundant and easily accessible in dogs. The collection procedure is minimally invasive compared to other sources like bone marrow. These stem cells can differentiate into various cell types, including chondrocytes, which are essential for cartilage repair. This ability may help in regenerating damaged cartilage in osteoarthritic joints. ADMSCs s

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Eriksen, Erik Fink, Osvandre Lech, Gilberto Yoshinobu Nakama, and Denise M. O’Gorman. "Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal® Joint—A Review." Clinics and Practice 11, no. 4 (2021): 901–13. http://dx.doi.org/10.3390/clinpract11040104.

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Modern advances in molecular medicine have led to the reframing of osteoarthritis as a metabolically active, inflammatory disorder with local and systemic contributing factors. According to the ‘inflammatory theory’ of osteoarthritis, immune response to an initial damage is the key trigger that leads to progressive joint destruction. Several intertwined pathways are known to induce and govern articular inflammation, cartilage matrix degradation, and subchondral bone changes. Effective treatments capable of halting or delaying the progression of osteoarthritis remain elusive. As a result, suppl

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Valente, Catarina, Laura Haefliger, Julien Favre, and Patrick Omoumi. "Ossification of the acetabular rim: a highly prevalent finding in asymptomatic non-osteoarthritic hips of all ages." European Radiology 31, no. 9 (2021): 6802–9. http://dx.doi.org/10.1007/s00330-021-07750-y.

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Abstract Objective To estimate the prevalence of acetabular rim ossifications in the adult population with asymptomatic, morphologically normal hips at CT and to determine whether the presence of these ossifications is associated with patient- or hip-related parameters. Methods We prospectively included all patients undergoing thoracoabdominal CT over a 3-month period. After exclusion of patients with a clinical history of hip pathology and/or with signs of osteoarthritis on CT, we included a total of 150 hips from 75 patients. We analyzed the presence and the size of ossifications around the

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Zhang, Yaxin, Jihang Dai, Lianqi Yan, et al. "DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a." Oxidative Medicine and Cellular Longevity 2022 (July 20, 2022): 1–19. http://dx.doi.org/10.1155/2022/9468040.

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Osteoarthritis (OA) has been reported as a progressive disease in the elderly, primarily characterized by degenerated articular cartilage. There has been no satisfactory drug for the treatment of OA. DL-3-n-butylphthalide (NBP), a small molecule compound extracted from celery seeds, may have antiapoptotic, antioxidant, and anti-inflammatory activities in numerous studies. However, the effects of NBP on OA and its mechanisms have been rarely reported. In this study, the effect of NBP on OA in vitro and in vivo and its possible mechanism were investigated. The results showed that NBP injection i

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