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Relevant bibliographies by topics / Osteogenesis bone / Dissertations / Theses

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Dissertations / Theses on the topic 'Osteogenesis bone'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Midha, Swati. "Osteogenesis in porous biomaterials for bone regeneration." Thesis, Ulster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674920.

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2

Baigrie, Carolyn Frances. "Collagen genes in osteogenesis imperfecta." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291073.

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3

Ma, Li. "The influence of nicotine on angiogenesis and osteogenesis in bone regeneration." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508440.

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4

Ma, Li, and 马丽. "The influence of nicotine on angiogenesis and osteogenesis in bone regeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508440.

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5

Hrit, Manuela. "Acceleration of bone formation in distraction osteogenesis by bone morphogenetic protein-7." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101142.

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The manipulation of the molecular mechanisms that govern distraction osteogenesis (DO) in order to increase the biomechanical strength of new bone and to accelerate its synthesis has been the topic of intense research during the past decades.<br>Bone morphogenetic proteins (BMPs) play an important role in bone formation. In this study, using a rabbit model of DO, the expressions of BMP's major intracellular signalling molecules, Smad proteins, was analyzed and correlated with the expression of BMP ligands and receptors. Based on these results, which confirmed post-receptor activity for the BMP

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6

Barragan-Adjemian, Maria del Cielo Bonewald Lynda F. "Mechanisms of mineralization in bone." Diss., UMK access, 2006.

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Thesis (Ph. D.)--School of Dentistry. University of Missouri--Kansas City, 2006.<br>"A dissertation in oral biology and cell biology and biophysics." Advisor: Lynda F. Bonewald. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Nov. 12, 2007. Includes bibliographical references (leaves 121-139). Online version of the print edition.

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7

Chay, Siew Han. "Vascular endothelial growth pattern during demineralized bone matrix (intramembranous bone origin) induced osteogenesis." Click to view the E-thesis via HKUTO, 1999. http://sunzi.lib.hku.hk/HKUTO/record/B38628417.

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8

謝秀嫻 and Siew Han Chay. "Vascular endothelial growth pattern during demineralized bone matrix (intramembranous bone origin) induced osteogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B38628417.

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9

Alfayez, Eman Saud. "Synergizing angiogenesis and osteogenesis in a smart bone substitute." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/synergizing-angiogenesis-and-osteogenesis-in-a-smart-bone-substitute(ad38b2b9-e1e3-42ce-88a0-91a764bc14e6).html.

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The major aim of this project was to develop a biologically active bone scaffold that could induce vascularization in critical-size defects (CSD) and hence bone formation. In this study, functionalization of three-dimensional (3D) printed biphasic calcium phosphate (BCP) scaffolds was investigated. The first functionalization approach involved printing scaffolds with two different pore geometries and sizes; square (400μ) and round (800μ). The second was by coating scaffolds with DAR16-II; a self-assembly peptide that forms a hydrogel nanostructure mimicking extracellular matrix (ECM). A rabbit

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10

Hamade, Fares. "Enhanced bone formation during distraction osteogenesis in FGFR3 deficient mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112630.

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Distraction Osteogenesis (DO) is a technique for bone lengthening and filling of bone defects following trauma, infection or resection of tumors. DO consists of an osteotomy of the bone to be lengthened, followed by controlled distraction of the bone segments with an external fixator until the desired lengthening is obtained (distraction phase). This is followed by the consolidation phase, during which the external fixator is kept in place until the newly formed bone in the distracted zone consolidates. This phase is long and may cause numerous problems. Ongoing research aims at finding a meth

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11

Lean, Jennifer Maree. "Mechanical stimulation of bone formation in the rat." Thesis, St George's, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263682.

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12

Liu, Gang. "Controlled Release of Growth Factors from Microsphere Scaffolds for Osteogenesis." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367685.

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Large bone defects present a major challenge to orthopaedic surgeons. Tissue engineering technology may provide a potential strategy to repair such defects, which involves the implantation of scaffold constructs typically loaded with cells and growth factors. It is expected that such growth factors loaded scaffolds can produce optimal microenvironments for the differentiation of seeded cells. The purpose of this project was to construct a dual growth factor release system in vitro using gelatin hydrogel and microspheres (MSs) to carry and deliver two growth factors, which have different effect

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13

Djasim, U. M. "Craniofacial distraction osteogenesis effects of rhythm of distraction on bone regeneration /." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/14041.

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14

Abbasi, Naghmeh. "Bone Tissue Regeneration by Using Melt Electrospinning Writing (MEW)." Thesis, Griffith University, 2020. http://hdl.handle.net/10072/393981.

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Biomaterial scaffolds engineered to facilitate osteogenesis which can subsequently remodel in a similar fashion to that of natural tissue, is an ideal clinical strategy for treating bone defects in the maxillofacial region. This study has developed, using a novel melt electrowriting (MEW) technique, various graded porous polycaprolactone (PCL) scaffolds able to imitate the bimodal structure of cortical and cancellous bone tissue in terms of their morphological pore structure. These scaffolds were subsequently shown to facilitate the proliferation of osteoblasts with significant alkaline phosph

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15

Hariri, Firdaus. "Alveolar distraction osteogenesis for dental implant rehabilitation inreconstructed jaws." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661514.

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16

Jagger, Christopher John. "The effect of oestrogen on mechanically-induced bone formation in the eighth caudal vertebra of rats." Thesis, St George's, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343599.

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17

Kawai, Shunsuke. "In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes." Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/245828.

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京都大学<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第22143号<br>医博第4534号<br>新制||医||1039(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授妻木範行, 教授森本尚樹, 教授別所和久<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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18

Williams, Bristol Marie. "Effects of tricalcium phosphate coated titanium on adjacent early bone formation." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/ABSTRACTS/2007-005-Williams-index.html.

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Thesis (M.S. )--University of Tennessee Health Science Center, 2007<br>Title from title page screen (viewed on July 28, 2008). Research advisor: Joo L. Ong, Ph.D. Document formatted into pages (iv, 36 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 33-36).

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19

Halling, Linder Cecilia. "Biochemical and functional properties of mammalian bone alkaline phosphatase isoforms during osteogenesis." Doctoral thesis, Linköpings universitet, Avdelningen för mikrobiologi och molekylär medicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-127100.

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The human skeleton is a living and dynamic tissue that constantly is being renewed in a process called bone remodeling. Old bone is resorbed by osteoclasts and new bone is formed by osteoblasts. Bone is a composite material made up by mineral crystals in the form of hydroxyapatite (calcium and phosphate) that provides the hardness of bone, and collagen fibrils that provides elasticity and flexibility. Alkaline phosphatase (ALP) is a family of enzymes that is present in most species and catalyzes the hydrolysis of various phosphomonoesters at alkaline pH. Despite the generalized use of ALP as a

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20

Shi, Xiaojian. "Reconstruction of ankylotic and resected mandibular condyle by transport distraction osteogenesis." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39634486.

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21

Zhou, Yinghong. "Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/63002/1/Yinghong_Zhou_Thesis.pdf.

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The body of work presented in this dissertation has demonstrated that the interactions between donor cells and host cells are critical for bone repair and regeneration. The donor cells secrete VEGF which activates the downstream PI3K/Akt signaling pathway, ultimately leading to host cell recruitment and robust bone regeneration. The findings from this dissertation may provide a scientific rationale for the development of novel therapeutic strategies in the treatment and management of bone defects.

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22

Wei, Fei. "The osteoimmune effect of bone morphogenetic protein-2 in bone regeneration and biomaterial modification." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/198148/1/Fei_Wei_Thesis.pdf.

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Bone morphogenetic protein-2 (BMP2), one of most well-known osteoinductive molecules, has been extensively used in the orthopedics and dentistry. However, inflammatory reactions are regularly reported for its side effect. This project investigated the immune environment induced by BMP2 and unveiled the regulation of BMP2 in the cross talk between immune cells and bone forming cells. This project provides better understanding of BMP2 application in the treatment of fracture healing and bone-related diseases.

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23

Sipola, A. (Annina). "Effects of vascular endothelial growth factor (VEGF-A) and endostatin on bone." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514293184.

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Abstract Angiogenesis is essential for the replacement of cartilage by bone during skeletal growth and regeneration. Vascular endothelial growth factor-A (VEGF-A) is a key regulator of angiogenesis whereas endostatin, a potent inhibitor of endothelial cell proliferation and migration, is a natural antagonist of VEGF-A. The regulatory roles of these peptides in angiogenesis, bone formation and bone cells were investigated in this study. In the present work we studied the effects of VEGF-A, delivered with an adenoviral vector, on the recovery of bone drilling defects in rat femur. Our data con

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24

Åström, Eva. "Bisphosphonate treatment of children and adolescents with osteogenesis imperfecta (OI) : effects on clinical symptoms and bone turnover /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-347-4/.

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25

Plant, Andrea. "Investigation of the molecular basis for oestrogen's stimulatory action on bone formation in female mice." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368081.

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26

Shi, Xiaojian, and 施曉健. "Reconstruction of ankylotic and resected mandibular condyle by transport distraction osteogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39634486.

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27

Chua, Hannah Daile P. "Distraction osteogenesis versus orthognathic surgery which is better for cleft lip and palate patients? /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41758195.

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28

Campisi, Paolo. "Characterization of the expression of bone morphogenetic proteins during distraction osteogenesis of the mandible." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32980.

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Distraction osteogenesis is a form of in vivo tissue engineering used to lengthen bone. Bone morphogenetic proteins (BMPs) are known mediators of bone formation during the distraction of enchondral bones. Their role in the distraction of membranous bones remains unknown. A rabbit model was used to characterize the expression of BMP-2, 4 and 7 during mandibular distraction osteogenesis. Fourteen animals were subjected to a defined distraction protocol. At weekly intervals, two rabbits were sacrificed and the generate bone harvested for radiographic, bone densitometric, histologic and immunohist

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29

Johnson-Lynn, Sarah Elizabeth. "Novel electrochemical patterning of titanium alloy to control osteogenesis at the bone-implant interface." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2407.

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The aims of this thesis were to fully characterise the surface properties of titanium alloy treated with a novel process of electrochemical etching and to assess the effect of these surfaces on osseointegration and the behaviour of osteoblasts. In vitro investigation was performed using rat osteoblasts and human mesenchymal cells. Significant differences were observed in cell polarity and cell area between cells cultured on 3V and 5V and those treated at 9V. Significantly greater mean focal adhesion area and mean number of focal adhesions per unit cell area were also observed between the 3V an

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30

Hartikka, H. (Heini). "Genetic factors in bone disorders:osteogenesis imperfecta, juvenile osteoporosis and stress fractures." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:951427718X.

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Abstract Genetic factors and their resulting phenotypes were evaluated in three different bone disorders: osteogenesis imperfecta (OI), juvenile idiopathic osteoporosis (JIO), and stress fractures. The spectrum of the OI phenotypes caused by mutations in the COL1A1 and COL1A2 genes is well defined, but the mechanisms by which the variations affect the hearing phenotype are not well-known. A total of 54 Finnish OI patients with previously diagnosed hearing loss, or aged 35 or more years, were analyzed here for mutations in COL1A1, or COL1A2. Altogether, 49 mutations were identified, of which 4

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31

Petersson, Ulrika. "Studies on three matrix molecules in bone and dentin /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-702-9/.

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32

Cestari, Tania Mary. "Aspectos celulares, teciduais e moleculares da osteogênese ectópica e ortotópica induzida pela matriz alogênica óssea e dentinária." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/25/25142/tde-02062009-111408/.

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O objetivo do atual trabalho, foi correlacionar os eventos celulares e teciduais com a expressão das proteínas VEGF, BMP-7, RANKL e OPG durante a osteogênese ectópica e ortotópica, induzida pela matriz óssea (MO) e dentinária (MD) alogênica. Matrizes alogênicas desmineralizada em HCl a 0,6N, obtidas de fêmur e incisivo de ratos, fori implantada entre as fáscias musculares da coxa e em defeito trans-ósseo de 8mm de diâmetro nos ossos parietais. As análises radiográfica e histomorfométrica da neoformação óssea e, a imunohistoquímica e o western blotting para as proteínas VEGF, BMP, RANKL e OPG,

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33

Lee, Lucinda. "Cell and Gene Therapy Strategies for Treatment of Bone Fragility Disorders." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22007.

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Current therapies for bone fragility disorders such as Osteogenesis Imperfecta (OI) can reduce fracture risk by improving bone quantity but not bone quality. Cell and/or gene therapy strategies hold promise for addressing the fundamental deficiencies in genetic bone disease but involve a number of technical hurdles that need to be overcome. This thesis takes a stepwise approach to address some of these challenges. Allogenic bone marrow transplantation (BMT) from healthy donors has been suggested for several decades to be able to repopulate the bone compartment with genetically healthy cells.

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34

Mah, Michelle Clare. "Functional outcomes and long term complications following distraction osteogenesis of the maxilla and mandible: asystematic review." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50639626.

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Background Distraction osteogenesis (DO) was first applied on the human craniofacial skeleton in 1992 by McCarthy et al.1 who performed lengthening of the mandible in patients with hemifacial microsomia and Nager’s syndrome. Further advances in this field have since then led to the widespread use of this modality for the treatment of numerous congenital and acquired craniofacial skeletal anomalies. In 2001, a review by Swennen et al2 concluded that up to year 1999, this form of treatment was gaining intense popularity but that the main drawbacks included insufficient data on long term result

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35

Almeida, Júnior Paulo. "Influência de três meios de armazenamento no processo de reparo do enxerto ósseo autógeno : análise histomorfométrica e imunoistoquímica em coelhos /." Araçatuba : [s.n.], 2009. http://hdl.handle.net/11449/101066.

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Orientador: Osvaldo Magro Filho<br>Banca: Élio Hitoshi Shinohara<br>Banca: Idelmo Rangel Garcia Júnior<br>Banca: Fábio Yoshio Tanaka<br>Banca: André Caroli Rocha<br>Resumo: Proposição: O objetivo deste trabalho foi avaliar a influência de três meios de armazenamento temporário no processo de reparo de enxertos ósseos retirados de calota craniana e fixados em mandíbula de coelhos. Material e Método: Foram removidos dois blocos ósseos de 9mm da calota craniana de 40 coelhos machos e colocados no ângulo mandibular direito e esquerdo. O enxerto ósseo foi fixado ao leito receptor imediatamente após

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36

Vernon, Lauren Louise. "A Comparison of the Osteogenic Tissue Engineering Potential of Dental-Derived Stem Cell Lines: Stem Cells from Human Exfoliated Deciduous Teeth (SHEDs) vs. Periodontal Ligament Stem Cells (PERIOS)." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_theses/19.

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The goal of this study is to assess the osteogenic potential of two types of dental stem cell lines within a tissue engineering application. More specifically, the goal of this study is to find a readily abundant cell source with capacity to express an osteogenic phenotype. There are two parameters utilized to evaluate tissue engineering potential of cells: proliferation rate and differentiation potential. Briefly, proliferation rate is the speed at which cells divide and differentiation potential determines if cells are capable of committing towards specific lineages (e.g. osteogenic). The

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37

Somogyi-Ganss, Eszter. "Novel non-collagenous modulators of biomineralization in bone and dentin /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-101-6/.

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38

Dai, Zhijie. "The role of sodium/myo-inositol cotransporter 1 and myo-inositol in osteogenesis and bone formation." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43783533.

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39

Dai, Zhijie, and 戴志洁. "The role of sodium/myo-inositol cotransporter 1 and myo-inositol in osteogenesis and bone formation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43783533.

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40

Kisiel, Marta. "Bone Enhancement with BMP-2 for Safe Clinical Translation." Doctoral thesis, Uppsala universitet, Polymerkemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-188027.

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Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of bone regeneration. However, BMP-2 delivery in a conventional collagen scaffold needs a high dose to achieve an effective outcome. Moreover, such dosage may lead to serious side effects. The aim of the following thesis was to find clinically acceptable strategies reducing the required dose of BMP-2 by improving the delivery and optimizing the preclinical testing of the new approaches. In all the studies hyaluronic acid (HA) hydrogels was used as a carrier for BMP-2. The HA hydrogel/BMP-2 construct was m

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Raman, Harini. "AN ORGANIC BOVINE HYDROXYAPATITE-PLGA COMPOSITES FOR BONE TISSUE ENGINEERING." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_theses/201.

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The objective of the present study was to synthesize porous, biodegradable poly (D, l- lactide-co-glycolide) PLGA-B-HA (Bovine hydroxyapatite) composite and evaluate the effect of ceramic content on bone marrow cell differentiation in vitro. A macroporous biodegradable PLGA-B-HA composite with the pore size varying from 0.1 to 1000?? and a highly interconnected structure was fabricated using the freeze-drying/lyophilization technique. A pilot study was done to determine the effects of B-HA on to the osteoblast function. The main study was done to determine the effect of the increase in B-HA co

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Sun, Zongyang. "Masticatory strain and bone growth of two osteogenic surfaces : cranial sutures and the mandibular osteodistraction site /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/6382.

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Stewart, Kenneth J. "Morphological and biomechanical effects of distraction rate and Insulin-like Growth Factor-1 in distraction osteogenesis of the rabbit mandible." Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297465.

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The effects of the rate of distraction and of local infusion of IGF-1 upon bone deposition during mandibular distraction osteogenesis was studied in a rabbit model. Five groups of rabbits were studied. All rabbits, except sham operated controls, underwent distraction to 15 mm. The variables studied were the rate of distraction (0.5 mm twice a day versus 1.5 mm twice a day) and the effects of local IGF-1 infusion via osmotic infusion pumps. Analysis by DEXA scanning and three point bending 28 days after the end of distraction demonstrated no difference in density or strength of bone between the

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Haidar, Ziyad. "A hybrid core-shell rhOP-1 nanoparticulate delivery system for enhanced new bone regeneration in distraction osteogenesis." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86713.

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Distraction osteogenesis (DO) is a prevalent surgical technique for the correction of congenital orthopaedic deformities and craniofacial developmental conditions. Yet, clinical benefits continue to be limited by a number of complications mainly as a result of the protracted treatment time during which the fixator has to be kept in situ until the newly-formed bone in the distracted zone consolidates (or hardens), thus exacerbating significant medical, psychological and socio-economical problems on patients, their families and caregivers. On the other hand, protein therapy particularly with the

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Montoya-Sanhueza, Germán Andrés. "Functional anatomy, osteogenesis and bone microstructure of the appendicular system of African mole-rats (Rodentia: Ctenohystrica: Bathyergidae)." Doctoral thesis, Faculty of Science, 2021. http://hdl.handle.net/11427/32855.

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In comparison to their ecophysiological and behavioral aspects, the skeletal system of African mole-rats (Bathyergidae) has been relatively understudied. Only a few studies have assessed their skeletal system, but these have mostly focused on their cranial and dental systems, with little attention on their postcranial skeleton. This PhD thesis provides a considerable amount of information about the functional anatomy, morphological diversity and postnatal bone morphogenesis of the appendicular system of these subterranean mammals. African mole-rats are small mammals highly adapted to the hypog

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Böse, Thomas [Verfasser]. "Stimulation of angiogenesis and osteogenesis in a dynamic co-culture model of bone tissue engineering / Thomas Böse." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1145324355/34.

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Policastro, Gina. "Osteogenic-Peptide Functionalized Polymeric Materials for Bone Regeneration Applications." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1460370012.

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Miranda, Fábio Vieira de. "Efeito da administração local e sistêmica da atorvastatina no reparo ósseo de defeitos críticos em calvária de ratos /." Araçatuba, 2020. http://hdl.handle.net/11449/192123.

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Orientador: Leonardo Perez Faverani<br>Resumo: Objetivo: O presente estudo teve como objetivo comparar o efeito da Atorvastatina, aplicada de forma local e sistêmica, em defeitos críticos de calotas de ratos. Material e médodos: 36 (trinta e seis) ratos (Rattus norvegicus, albinus, Wistar), adultos foram divididos aleatoriamente em 3 grupos, o grupo aplicação de membrana de colágeno com água destilada (GAD) com defeitos de tamanho crítico contendo água destilada; o grupo aplicação Sistêmica de Atorvastatina (GAS) foram realizado defeitos de tamanho crítico e os animais foram tratados com atorv

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Payne, Scott Andrew. "An Electron Energy-Loss Spectroscopic Investigation of Molecular Interactions at Hydroxyapatite-Collagen Interfaces in Healthy and Diseased (Osteogenesis Imperfecta) Human Bone and Biomineralized Tissue-Engineered Bone." Diss., North Dakota State University, 2018. https://hdl.handle.net/10365/27928.

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At its primary level (nm scale) bone is a nanocomposite consisting of a mineral (hydroxyapatite) phase which gives bone its strength and an organic (type I collagen) phase giving bone its fracture toughness. Hydroxyapatite, (HAP) Ca10(PO4)6(OH)2, is the most abundant mineral in the human body. Bone tissue has a complex hierarchical structure spanning multiple length scales (cm to nm). Characterization of mineral composition in biomineralized tissues such as bone at their primary level, is very challenging and requires instrumentation with nanometer-scale spatial resolution. Transmission electr

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Krebs, Melissa Diane. "LOCALIZED AND SUSTAINED RELEASE OF PLASMID DNA OR siRNA FROM BIOMATERIAL SCAFFOLDS TO PROMOTE OSTEOGENESIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1277223746.

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