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Journal articles on the topic 'Osteogenesis bone'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Zhang, Bo, Yali Li, Yang Yu, et al. "MicroRNA-378 Promotes Osteogenesis-Angiogenesis Coupling in BMMSCs for Potential Bone Regeneration." Analytical Cellular Pathology 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/8402390.

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Bone tissue regeneration was closely associated with osteogenesis and angiogenesis. The harmonious regulation of osteogenetic and angiogenic growth factors would enhance bone regeneration, while the imbalance of that would lead to local excessive bone formation or vascular mass due to exogenous delivery. Therefore, microRNA is believed to regulate multiple metabolism progress through endogenous signaling pathways on the gene level. In this work, we identified microRNA 378 as a positive regulator of osteogenesis and angiogenesis simultaneously and also observed an increase of microRNA 378 than

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Mantsou, Aglaia, Eleni Papachristou, Panagiotis Keramidas, et al. "A Novel Drastic Peptide Genetically Adapted to Biomimetic Scaffolds “Delivers” Osteogenic Signals to Human Mesenchymal Stem Cells." Nanomaterials 13, no. 7 (2023): 1236. http://dx.doi.org/10.3390/nano13071236.

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This work describes the design, preparation, and deep investigation of “intelligent nanobiomaterials” that fulfill the safety rules and aim to serve as “signal deliverers” for osteogenesis, harboring a specific peptide that promotes and enhances osteogenesis at the end of their hydrogel fibers. The de novo synthesized protein fibers, besides their mechanical properties owed to their protein constituents from elastin, silk fibroin and mussel-foot adhesive protein-1 as well as to cell-attachment peptides from extracellular matrix glycoproteins, incorporate the Bone Morphogenetic Protein-2 (BMP2)

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Feng, Guiyu, Wei Liu, Yao Yu, et al. "Angiogenesis coupled with osteogenesis in a bone tissue engineering scaffold enhances bone repair in osteoporotic bone defects." Biomedical Materials 18, no. 4 (2023): 045002. http://dx.doi.org/10.1088/1748-605x/accf55.

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Abstract Increased life expectancy has resulted in an increase in osteoporosis incidence worldwide. The coupling of angiogenesis and osteogenesis is indispensable for bone repair. Although traditional Chinese medicine (TCM) exerts therapeutic effects on osteoporosis, TCM-related scaffolds, which focus on the coupling of angiogenesis and osteogenesis, have not yet been used for the treatment of osteoporotic bone defects. Panax notoginseng saponin (PNS), the active ingredient of Panax notoginseng, was added to a poly (L-lactic acid) (PLLA) matrix. Osteopractic total flavone (OTF), the active ing

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Masurkar, Deepika, Priyanka Jaiswal, and Diksha Agrawal. "Alveolar Distraction Osteogenesis." Journal of Evolution of Medical and Dental Sciences 10, no. 38 (2021): 3462–65. http://dx.doi.org/10.14260/jemds/2021/701.

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Resorbed alveolar ridges, which can be horizontal or vertical in size, are one of the most prevalent issues addressed by dental experts. One of the therapy options for addressing the weak sections of the alveolar ridges is alveolar distraction osteogenesis. Alveolar distraction osteogenesis is a biological process that includes gradual traction between vascularized bone segments in order to generate new bone. Typically, an osteotomy is done, followed by the placement of an osteodistraction device to manage the separating process. This approach eliminates the need for bone grafts by producing t

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Łukowicz, Krzysztof, Karolina Fijał, Aleksandra Nowak, and Anna M. Osyczka. "Connexin 43 in osteogenesis." Postępy Higieny i Medycyny Doświadczalnej 74 (September 25, 2020): 406–15. http://dx.doi.org/10.5604/01.3001.0014.4153.

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Skeleton formation and its proper functioning is possible thanks to specialized bone tissue cells: bone forming osteoblasts, bone resorbing osteoclasts and osteocytes located in bone cavities. Gap junctions are transmembrane channels connecting neighboring cell. Thanks to gap junctions it is possible for signals to be directly transmitted by cells. Gap junction type channels, and more specifically the connexin proteins that build them, have a key impacton the bone turnover process, and thus on both bone building and remodeling. A particularly important connexin in bone tissue is connexin43 (Cx

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Kim, Jung-Eun. "Osteoclastogenesis and Osteogenesis." International Journal of Molecular Sciences 23, no. 12 (2022): 6659. http://dx.doi.org/10.3390/ijms23126659.

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Stewart, Sarah, Alastair Darwood, Spyros Masouros, Claire Higgins, and Arul Ramasamy. "Mechanotransduction in osteogenesis." Bone & Joint Research 9, no. 1 (2020): 1–14. http://dx.doi.org/10.1302/2046-3758.91.bjr-2019-0043.r2.

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Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a biochemical response, which ultimately alters the phenotype and function of the cell, is described as mechanotransduction. This review aims to describe the fundamental physiology and biomechanisms that occur to induce osteogenic adaptation of a cell following application of a physical stimulus. Considerable developments have been made in recen

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Wang, Junjie, Bo Yuan, Ruixue Yin, and Hongbo Zhang. "Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration." Journal of Functional Biomaterials 14, no. 3 (2023): 169. http://dx.doi.org/10.3390/jfb14030169.

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Physical stimuli play an important role in one tissue engineering. Mechanical stimuli, such as ultrasound with cyclic loading, are widely used to promote bone osteogenesis; however, the inflammatory response under physical stimuli has not been well studied. In this paper, the signaling pathways related to inflammatory responses in bone tissue engineering are evaluated, and the application of physical stimulation to promote osteogenesis and its related mechanisms are reviewed in detail; in particular, how physical stimulation alleviates inflammatory responses during transplantation when employi

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Palumbo, Carla, Francesca Paganelli, and Marzia Ferretti. "Ossification in Normal and Pathological Contexts: The Key Role of Static Osteogenesis vs. Dynamic Osteogenesis in the Etiopathology of Some Skeletal Alterations." Biomolecules 15, no. 5 (2025): 733. https://doi.org/10.3390/biom15050733.

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This Commentary is intended to start a discussion in the field of calcification/ossification related to osteogenesis. It highlights that two types of bone formation, static osteogenesis (SO) and dynamic osteogenesis (DO), are temporally followed by each other in bone histogenesis and bone lesion repair. Moreover, they also represent the common denominator in the pathological processes of both calcification and peculiar ossifications, such as heterotopic ossification and the formation of supernumerary skeletal segments. The final objective is to propose a different interpretation of certain bon

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Yan, Wei Qi, Jie Feng, Q. Chen, Di Sheng Yang, Ying Zhao, and Shi Gui Yan. "The Osteogenic Potential of Stem Cell- and BMP2 Gene-Activating Bioceramic In Vivo." Key Engineering Materials 284-286 (April 2005): 941–44. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.941.

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Stimulation of bone healing through local application of growth factors from implants may improve the clinical outcome in fracture treatments. However, the growth factors in reconstructive application require supraphysiologic dosing and considerable expense while hampering their clinical application. Genetic modification of mesenchymal stem cells (MSCs) to both produce and respond to osteogenic factors may have potential for use in enhancing bone healing. In this study, MSCs were genetically modified by a recombinant adenoviral containing the gene for human bone morphogenetic protein 2 (hBMP-2

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11

Moosa, Shahida. "Perinatal lethal osteogenesis imperfecta." South African Journal of Radiology 16, no. 4 (2012): 141–42. http://dx.doi.org/10.4102/sajr.v16i4.261.

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Osteogenesis imperfecta (OI) is a heterogeneous group of genetic bone disorders that are characterised by decreased bone mass, increased bone fragility and susceptibility to fractures. The severe, perinatal lethal form (Type II) (OMIM 166210) is characterised by bone fragility, with perinatal fractures, severe bowing of long bones, undermineralisation, and death in the perinatal period owing to respiratory insufficiency. The overall prevalence of OI Type II is unknown. There are three subtypes of OI Type II (A, B and C) that are characterised by different radiological features, and may be caus

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Lingaraju, Naresh, PJ Nagarathna, R. Vijayalakshmi, and P. Sheshadri. "Osteogenesis Imperfecta/Lobstein Syndrome associated with Dentinogenesis Imperfecta." Journal of Contemporary Dental Practice 14, no. 1 (2013): 140–42. http://dx.doi.org/10.5005/jp-journals-10024-1288.

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ABSTRACT Osteogenesis imperfecta is a collagen related disorder characterized by increased bone fragility and low bone mass. The important oral finding in osteogenesis imperfect is the presence of dentinogenesis imperfecta. This article presents a case of osteogenesis imperfecta (type IV B) with dentinogenesis imperfecta where a 7-year-old girl had opalacent primary teeth associated with severe bone deformity, scoliosis, barrel shaped rib cage, and short stature. The clinical, radiographic ad histologic features are reviewed along with management aspects. How to cite this article Lingaraju N,

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Li, Jialiang, Zhongwei Sun, Xinyu Wei, Qinghua Tan, and Xijing He. "Effect of Structure on Osteogenesis of Bone Scaffold: Simulation Analysis Based on Mechanobiology and Animal Experiment Verification." Bioengineering 11, no. 11 (2024): 1120. http://dx.doi.org/10.3390/bioengineering11111120.

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Porous scaffolds, whose mechanical and biological properties are greatly affected by structure, are new treatments for bone defects. Since bone repair is related to biomechanics, analyzing the osteogenesis in scaffolds based on mechanical stimulation may become a more effective method than traditional biological experiments. A tissue regeneration algorithm based on mechanical regulation theory was implemented in this study to evaluate the osteogenesis of classical scaffolds (Gyroid, I-WP, and Diamond). In vivo experiments were used to verify and supplement the simulation results. Different app

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Amrullah, Siti Sarah Aulia, Rosida Sani, Nurfadhilah Arifin, and Muhammad Ruslin. "Augmentasi tulang alveolar dengan osteogenesis distraksi Alveolar ridge augmentation using distraction osteogenesis." Journal of Dentomaxillofacial Science 11, no. 3 (2012): 174. http://dx.doi.org/10.15562/jdmfs.v11i3.334.

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Augmentation of the alveolar ridge is widely performed in implant treatment to create predictable function andesthetics in area with inadequate bone volume. There are some different ways to augment the alveolar ridge.Distraction osteogenesis is a new method in increasing the width of the ridge and preparing a sufficient bed for implantor prosthesis. Distraction osteogenesis result in formation of new bone between bone segments that are separatedgradually by incremental traction. Alveolar widening by distraction osteogenesis is an alternative method forreconstructing alveolar atrophy that is si

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Kawai, Gou, Takatoshi Ohno, Tomoko Kawaguchi, et al. "Human Dental Pulp Facilitates Bone Regeneration in a Rat Bone Defect Model." Bone and Tissue Regeneration Insights 4 (January 2013): BTRI.S10687. http://dx.doi.org/10.4137/btri.s10687.

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The objective of this work was to investigate the osteogenetic ability of the human dental pulp stem cells (hDPSCs) derived from human third molars. We induced alkaline phosphatase (ALP) activity and bone morphogenetic protein 2 (BMP-2) mRNA expression, the markers for bone formation, in hDPSCs by using osteoinductive factors. The implantation of hDPSCs with collagen sponge promoted osteogenesis and fracture healing in the femur of an immunocompromised rat, which was a bone defect model for pseudoarthrosis. Histological analyses revealed that after implantation of the hDPSCs, the size and numb

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Amir, Lisa R., Vincent Everts, and Antonius L. J. J. Bronckers. "Bone regeneration during distraction osteogenesis." Odontology 97, no. 2 (2009): 63–75. http://dx.doi.org/10.1007/s10266-009-0101-z.

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Hu, Jie, Jiahui Shao, Gan Huang, Jieyuan Zhang, and Shuting Pan. "In Vitro and In Vivo Applications of Magnesium-Enriched Biomaterials for Vascularized Osteogenesis in Bone Tissue Engineering: A Review of Literature." Journal of Functional Biomaterials 14, no. 6 (2023): 326. http://dx.doi.org/10.3390/jfb14060326.

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Bone is a highly vascularized tissue, and the ability of magnesium (Mg) to promote osteogenesis and angiogenesis has been widely studied. The aim of bone tissue engineering is to repair bone tissue defects and restore its normal function. Various Mg-enriched materials that can promote angiogenesis and osteogenesis have been made. Here, we introduce several types of orthopedic clinical uses of Mg; recent advances in the study of metal materials releasing Mg ions (pure Mg, Mg alloy, coated Mg, Mg-rich composite, ceramic, and hydrogel) are reviewed. Most studies suggest that Mg can enhance vascul

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Sun, Yuxin, Liangliang Xu, Shuo Huang, et al. "mir-21 Overexpressing Mesenchymal Stem Cells Accelerate Fracture Healing in a Rat Closed Femur Fracture Model." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/412327.

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MicroRNAs are small noncoding RNAs involved in numerous biological processes. Emerging pieces of evidence suggest that microRNAs play important roles in osteogenesis and skeletal homeostasis. Recent studies indicated the significant regulation function of mir-21 in osteogenesisin vitro, but little information is known about its veritable functionsin vivo. In the present study, we aimed to investigate the effect of mir-21 intervention on osteogenic differentiation of rats bone marrow derived mesenchymal stem cells (rBMSCs) and repair capacity in rats closed femur fracture model with internal fi

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19

Shevyrev, K. V., D. A. Shavyrin, D. V. Martynenko, et al. "Results of plate osteosynthesis of the femur at the patient with osteogenesis imperfecta." Osteoporosis and Bone Diseases 28, no. 1 (2025): 38–47. https://doi.org/10.14341/osteo13189.

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Osteogenesis imperfecta is a rare disease characterized by bone fragility, frequent fractures, bone deformities, and low bone mineral density. The relative risk of bone fractures in patients with osteogenesis imperfecta is 4–6 times higher than in the general population. In adult patients with osteogenesis imperfecta, the incidence of femoral shaft fractures is approximately 35 times higher than in the general population. According to modern literature data, the preferred method of osteosynthesis in such patients is intramedullary. Osteosynthesis with plates is associated with a high incidence

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20

Wan, Jun, Tao Ma, Yun Jin, and Shaodong Qiu. "The effects of morin on bone regeneration to accelerate healing in bone defects in mice." International Journal of Immunopathology and Pharmacology 34 (January 2020): 205873842096290. http://dx.doi.org/10.1177/2058738420962909.

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Restoring bone defects are the major challenge facing clinical trial therapy, particularly skull related problems. Morin, a naturally occurring compound, has pro-osteogenesis. This research focuses on assessing the role of morin for its pro-osteogenesis activities. We utilized in vivo and in vitro models to investigate the molecular-level mechanisms of morin’s osteoblastic biological activity. The effectiveness of morin on pro-osteogenesis (100 mg/kg/day) was assessed by monitoring modifications in the bone histomorphometry score, the development of immature osteoblasts from mesenchymal stems

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Huang, Xinqi, Xuefeng Pan, Bo Zhang, et al. "CircRFWD2 Promotes Osteogenic Differentiation of human Dental Pulp Stem Cells by Targeting miR-6817-5p Through BMP-Smad and p38 MAPK Pathway." Cell Transplantation 30 (January 1, 2021): 096368972110529. http://dx.doi.org/10.1177/09636897211052959.

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Dental pulp stem cells (DPSCs) are one promising cell source of mesenchymal stem cells in bone tissue engineering. However, it remains unknown that the molecules and signaling pathways involved in osteogenesis of DPSCs. Hence, this study investigated the functional roles and underlying mechanisms of circRFWD2 during osteogenesis of DPSCs. Knockdown of circRFWD2 suppressed osteogenesis of DPSCs significantly. Mechanistically, circRFWD2 could crosstalk with miR-6817-5p, which was an inhibitor of DPSCs osteogenesis. MiR-6817-5p functioned as a sponge of BMPR2, which regulated the phosphorylation

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Zhang, Ya-Li, Liang Liu, Yu-Wen Su та Cory J. Xian. "miR-6315 Attenuates Methotrexate Treatment-Induced Decreased Osteogenesis and Increased Adipogenesis Potentially through Modulating TGF-β/Smad2 Signalling". Biomedicines 9, № 12 (2021): 1926. http://dx.doi.org/10.3390/biomedicines9121926.

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Methotrexate (MTX) treatment for childhood malignancies has shown decreased osteogenesis and increased adipogenesis in bone marrow stromal cells (BMSCs), leading to bone loss and bone marrow adiposity, for which the molecular mechanisms are not fully understood. Currently, microRNAs (miRNAs) are emerging as vital mediators involved in bone/bone marrow fat homeostasis and our previous studies have demonstrated that miR-6315 was upregulated in bones of MTX-treated rats, which might be associated with bone/fat imbalance by directly targeting Smad2. However, the underlying mechanisms by which miR-

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Zheng, Sheng, Guan-Yu Hu, Jun-Hua Li, Jia Zheng, and Yi-Kai Li. "Icariin accelerates bone regeneration by inducing osteogenesis-angiogenesis coupling in rats with type 1 diabetes mellitus." World Journal of Diabetes 15, no. 4 (2024): 769–82. http://dx.doi.org/10.4239/wjd.v15.i4.769.

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BACKGROUND Icariin (ICA), a natural flavonoid compound monomer, has multiple pharmacological activities. However, its effect on bone defect in the context of type 1 diabetes mellitus (T1DM) has not yet been examined. AIM To explore the role and potential mechanism of ICA on bone defect in the context of T1DM. METHODS The effects of ICA on osteogenesis and angiogenesis were evaluated by alkaline phosphatase staining, alizarin red S staining, quantitative real-time polymerase chain reaction, Western blot, and immunofluorescence. Angiogenesis-related assays were conducted to investigate the relat

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Liu, Zuozhong, Chunling Shui, Lili Huang, and Yiming Qu. "Resveratrol facilitates bone marrow mesenchymal stem cells (BMSCs) differentiation to prevent osteoporosis via restraining of secreted frizzled-related protein 1 expression." Materials Express 11, no. 10 (2021): 1636–44. http://dx.doi.org/10.1166/mex.2021.2083.

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Secreted frizzled-related protein 1 (SFRP1) is associated with cell differentiation, and its expression can be modulated by resveratrol. However, their impacts on bone marrow mesenchymal stem cells (BMSCs)-induced osteogenesis and ovariectomy-triggered bone loss remain unclear. Therefore, we in this study aimed to dissect the regulation of resveratrol on SFRP1, along with its sequential effects on differentiation and osteoporosis prevention of BMSCs. The SFRP1 expression in the ovariectomized (OVX) mice-originated bone tissues, BMSCs and bone marrow-derived macrophages (BMMs), during their dif

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Okamoto, Tomoyo, Satoru Kodama, Nozomi Nomi, Shingo Umemoto, and Masashi Suzuki. "Expression of Bone Morphogenic Protein in Sinonasal Inverted Papilloma with New Bone Formation." Allergy & Rhinology 2, no. 1 (2011): ar.2011.2.0004. http://dx.doi.org/10.2500/ar.2011.2.0004.

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Inverted papilloma (IP) is a common benign tumor in the nose and sinus. Osteogenesis in sinonasal IP is extremely rare; to date, only five cases of IP with new bone formation appear in the literature. In addition, the mechanism of osteogenesis in IP remains unclear. Here, we describe three cases of IP with new bone formation and an investigation into a possible role for bone morphogenic protein (BMP) in osteogenesis. Of three patients with sinonasal IP with new bone formation, two were treated by endoscopic sinus surgery and one was followed up with watchful waiting. Tumor tissues were subject

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Wu, Laidi, Zhixin Liu, Li Xiao, et al. "The Role of Gli1+ Mesenchymal Stem Cells in Osteogenesis of Craniofacial Bone." Biomolecules 13, no. 9 (2023): 1351. http://dx.doi.org/10.3390/biom13091351.

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Glioma-associated oncogene homolog 1 (Gli1) is a transcriptional activator of hedgehog (Hh) signaling that regulates target gene expression and several cellular biological processes. Cell lineage tracing techniques have highlighted Gli1 as an ideal marker for mesenchymal stem cells (MSCs) in vivo. Gli1+ MSCs are critical for the osteogenesis of the craniofacial bone; however, the regulatory mechanism by which Gli1+ MSCs mediate the bone development and tissue regeneration of craniofacial bone has not been systematically outlined. This review comprehensively elucidates the specific roles of Gli

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Sun, Xiaowen, Yunyang Bai, Xiaona Zheng, et al. "Bone Piezoelectricity-Mimicking Nanocomposite Membranes Enhance Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Amplifying Cell Adhesion and Actin Cytoskeleton." Journal of Biomedical Nanotechnology 17, no. 6 (2021): 1058–67. http://dx.doi.org/10.1166/jbn.2021.3090.

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Ferroelectric biomaterials have been widely investigated and demonstrated to enhance osteogenesis by simulating the inherent electrical properties of bone tissues. Nevertheless, the underlying biological processes are still not wellunderstood. Hence, this study investigated the underlying biological processes by which bone piezoelectricity-mimicking barium titanate/poly(vinylidene fluoride-trifluoroethylene) nanocomposite membranes (BTO nanocomposite membranes) promote osteogenesis of Bone Marrow Mesenchymal Stem Cells (BMSCs). Ourresults revealed that the piezoelectric coefficient (d33) of na

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Coutinho, M. B., C. Marques, G. J. Mendes, and C. Gonçalves. "Successful bone-anchored hearing aid implantation in a patient with osteogenesis imperfecta." Journal of Laryngology & Otology 129, no. 11 (2015): 1133–36. http://dx.doi.org/10.1017/s0022215115002510.

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AbstractObjective:To report a case of successful bone-anchored hearing aid implantation in an adult patient with type III osteogenesis imperfecta, which is commonly regarded as a contraindication to this procedure.Case report:A 45-year-old man with type III osteogenesis imperfecta presented with mixed hearing loss. There was a mild sensorineural component in both ears, with an air–bone gap between 45 and 50 dB HL. He was implanted with a bone-anchored hearing aid. The audiological outcome was good, with no complications and good implant stability (as measured by resonance frequency analysis).C

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Hanif, Romzi, Muhammad Masykur Rahmat, and Cahya Yustisia Hasan. "Local application of biphosphonate as a biochemical barrier against bone graft resorption in mandibular reconstructio." Majalah Kedokteran Gigi Indonesia 5, no. 3 (2020): 143. http://dx.doi.org/10.22146/majkedgiind.45096.

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Mandibular reconstruction to restore functions and aesthetics after mandibular resection remains a major surgical challenge. This type of reconstruction using non-vascularized autogenous bone graft harvested from iliac bone has been popular given that this bone is numerous and donor site morbidity can be minimized, however, it is highly resorbable. Local application of bisphosphonate by immersing bone graft in biphosphonate manages to inhibit bone graft resorption prior to the formation of new bone to support the osteogenesis and osteointegration of bone grafts. This paper aimed at examining t

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Muñoz, Joseph, Neda S. Akhavan, Amy P. Mullins, and Bahram H. Arjmandi. "Macrophage Polarization and Osteoporosis: A Review." Nutrients 12, no. 10 (2020): 2999. http://dx.doi.org/10.3390/nu12102999.

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Over 200 million people suffer from osteoporosis worldwide. Individuals with osteoporosis have increased rates of bone resorption while simultaneously having impaired osteogenesis. Most current treatments for osteoporosis focus on anti-resorptive methods to prevent further bone loss. However, it is important to identify safe and cost-efficient treatments that not only inhibit bone resorption, but also stimulate anabolic mechanisms to upregulate osteogenesis. Recent data suggest that macrophage polarization may contribute to osteoblast differentiation and increased osteogenesis as well as bone

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Hsieh, Chin-Wen, Ling-Hua Chang, Yan-Hsiung Wang, et al. "Indoxyl Sulfate Inhibits Osteogenesis in Bone Marrow Mesenchymal Stem Cells through the AhR/Hes1 Pathway." International Journal of Molecular Sciences 25, no. 16 (2024): 8770. http://dx.doi.org/10.3390/ijms25168770.

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Uremic toxins cause bone disorders in patients with chronic kidney disease (CKD). These disorders are characterized by low turnover osteodystrophy and impaired bone formation in the early stages of CKD. Evidence indicates that the aryl hydrocarbon receptor (AhR) mediates signals that suppress early osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs). However, whether the AhR mediates the effects of indoxyl sulfate (IS), a uremic toxin, on BMSC osteogenesis remains unclear. We investigated whether IS affects osteogenesis through the AhR/Hes1 pathway. Expression levels of os

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Mahendra, I. Gede Bramantya Surya, and Dyah Purnaning. "Osteogenesis Imperfecta: Case Report and Literature Review." Jurnal Penelitian Pendidikan IPA 10, no. 11 (2024): 9106–13. https://doi.org/10.29303/jppipa.v10i11.9342.

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Osteogenesis imperfecta or brittle bone disease is a disorder of congenital bone fragility caused by genetic mutations in the procollagen type 1 code (COL1A1 and COL1A2). The global prevalence of children born with osteogenesis imperfecta is estimated to be 1 in 100,000 children worldwide. The diagnosis of osteogenesis imperfecta is based on history taking, physical examination, and supporting examination. Management of patients with osteogenesis imperfecta requires multidisciplinary treatment. There are several treatments that can be done, including conservative management, surgical managemen

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Bae, Chun-Sik, Seung-Hyun Kim, Taeho Ahn, et al. "Multiple Porous Synthetic Bone Graft Comprising Engineered Micro-Channel for Drug Carrier and Bone Regeneration." Materials 14, no. 18 (2021): 5320. http://dx.doi.org/10.3390/ma14185320.

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Due to high demand but limited supply, there has been an increase in the need to replace autologous bone grafts with alternatives that fulfill osteogenic requirements. In this study, two different types of bone grafts were tested for their drug carrying abilities along with their osteogenic properties. Two different types of alendronate-loaded bone grafts, Bio-Oss (bovine bone graft) and InRoad (biphasic synthetic bone graft) were observed to see how different concentrations of alendronate would affect the sustained release to enhance osteogenesis. In this study, defected ovariectomize-induced

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Fan, Desheng, Jiuqing Lu, Nijia Yu, Yajia Xie та Lei Zhen. "Curcumin Prevents Diabetic Osteoporosis through Promoting Osteogenesis and Angiogenesis Coupling via NF-κB Signaling". Evidence-Based Complementary and Alternative Medicine 2022 (7 листопада 2022): 1–13. http://dx.doi.org/10.1155/2022/4974343.

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Diabetic osteoporosis (DOP) is a metabolic disease which is characterized by impaired bone microarchitecture and reduced bone mineral density resulting from hyperglycemia. Curcumin, an effective component extracted from Curcuma longa, exhibits antioxidation, regulation of bone metabolism and hypoglycemic effects. The BMSC-mediated osteogenesis and angiogenesis coupling seems to be important in bone formation and regeneration. We aimed to explore the effect of curcumin on BMSC-mediated osteogenesis-angiogenesis coupling in high glucose conditions and underlying mechanisms. Our results showed th

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Dudchenko, Yevhenii S., Olena S. Maksymova, Vasyl S. Pikaliuk, Dmytro V. Muravskyi, Ludmila I. Kyptenko, and Gennadii F. Tkach. "Morphological Characteristics and Correction of Long Tubular Bone Regeneration under Chronic Hyperglycemia Influence." Analytical Cellular Pathology 2020 (April 6, 2020): 1–7. http://dx.doi.org/10.1155/2020/5472841.

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Introduction. Unsatisfactory consequences of bone regeneration disorders in diabetes mellitus (DM) patients, their high prevalence, complication number, and difficulties in treatment require further study and deeper understanding of reparative osteogenesis mechanisms under chronic hyperglycemia and finding new effective and affordable approaches to their treatment. Therefore, the aim of our work was to study the histological, ultramicroscopic, and histomorphometric features of reparative osteogenesis in rats with chronic hyperglycemia (CH), as well as to investigate the possibility of platelet

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Zhang, Ya-Li, Liang Liu, Yu-Wen Su, and Cory J. Xian. "miR-542-3p Attenuates Bone Loss and Marrow Adiposity Following Methotrexate Treatment by Targeting sFRP-1 and Smurf2." International Journal of Molecular Sciences 22, no. 20 (2021): 10988. http://dx.doi.org/10.3390/ijms222010988.

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Intensive methotrexate (MTX) treatment for childhood malignancies decreases osteogenesis but increases adipogenesis from the bone marrow stromal cells (BMSCs), resulting in bone loss and bone marrow adiposity. However, the underlying mechanisms are unclear. While microRNAs (miRNAs) have emerged as bone homeostasis regulators and miR-542-3p was recently shown to regulate osteogenesis in a bone loss context, the role of miR-542-3p in regulating osteogenesis and adipogenesis balance is not clear. Herein, in a rat MTX treatment-induced bone loss model, miR-542-3p was found significantly downregula

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Hamushan, Musha, Weijie Cai, Yubo Zhang та ін. "High-purity magnesium pin enhances bone consolidation in distraction osteogenesis model through activation of the VHL/HIF-1α/VEGF signaling". Journal of Biomaterials Applications 35, № 2 (2020): 224–36. http://dx.doi.org/10.1177/0885328220928550.

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Distraction osteogenesis has widespread clinical use in the treatment of large bone defects. Nonetheless, the prolonged consolidation period carries the risk of complications. Magnesium-based materials have been shown to promote bone regeneration in fracture healing both in vitro and in vivo. Here, we investigated whether high-purity magnesium could enhance bone formation in distraction osteogenesis. High-purity magnesium pins were placed into the medullary cavity in the rat distraction osteogenesis model. Results showed that the bone volume/total tissue volume, bone mineral density, and mecha

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Misbahuddin, Misbahuddin, and Ismail Mariyanto. "OSTEOGENESIS DISTRACTION USING COMBINED PLATE AND ILIZAROF FIXATOR IN THE TREATMENT OF BONE DEFECT: A CASE REPORT." Biomedika 11, no. 2 (2019): 113–20. http://dx.doi.org/10.23917/biomedika.v11i2.8598.

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Distraksi osteogenesis dan pemanjangan tulang telah digunakan untuk merekonstruksi hilangnya tulang dengan memungkinkan tulang baru terbentuk pada celah. Pada penelitian sebelumnya, pemanjangan tulang yang dipandu pelat telah berhasil mengobati hilangnya tulang pada tulang paha, tibia, dan mandibula. Penelitian ini melaporkan sebuah kasus fraktur tibia dengan kehilangan tulang kominutif yang diobati dengan fiksasi pelat dan pemanjangan tulang dengan fiksator cincin Ilizarov. Pada saat pengaitan, ketika segmen pemanjangan dikompresi dengan fragmen tulang, fragmen tulang difiksasi dengan sekrup

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Xu, Xinyun, Ling Zhao, Paul D. Terry, and Jiangang Chen. "Reciprocal Effect of Environmental Stimuli to Regulate the Adipogenesis and Osteogenesis Fate Decision in Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs)." Cells 12, no. 10 (2023): 1400. http://dx.doi.org/10.3390/cells12101400.

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Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into adipocytes and osteoblasts. Various external stimuli, including environmental contaminants, heavy metals, dietary, and physical factors, are shown to influence the fate decision of BM-MSCs toward adipogenesis or osteogenesis. The balance of osteogenesis and adipogenesis is critical for the maintenance of bone homeostasis, and the interruption of BM-MSCs lineage commitment is associated with human health issues, such as fracture, osteoporosis, osteopenia, and osteonecrosis. This review focuses on how external stimu

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Forell, Elaine, and R. C. Straw. "Bone Morphogenetic Proteins and Bone Derived Growth Factors." Veterinary and Comparative Orthopaedics and Traumatology 06, no. 03 (1993): 166–71. http://dx.doi.org/10.1055/s-0038-1633117.

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SummaryRecent studies suggest that local control of bone homeostatic and reparative mechanisms is most likely attributable to the interrelated function of a number of bone morphogenetic proteins (BMP) and bone derived growth factors. While osteogenesis is believed to be initiated by BMP, bone growth factors are thought to play a role in the promotion and maintenance of the newly induced bone and in the regulation of normal bone remodeling and repair. An overview of the current literature pertaining to BMP and the various bone derived growth factors is presented.While osteogenesis is believed t

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Kuznetsov, Sergei A., Mara Riminucci, Navid Ziran, et al. "The interplay of osteogenesis and hematopoiesis." Journal of Cell Biology 167, no. 6 (2004): 1113–22. http://dx.doi.org/10.1083/jcb.200408079.

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The ontogeny of bone marrow and its stromal compartment, which is generated from skeletal stem/progenitor cells, was investigated in vivo and ex vivo in mice expressing constitutively active parathyroid hormone/parathyroid hormone–related peptide receptor (PTH/PTHrP; caPPR) under the control of the 2.3-kb bone-specific mouse Col1A1 promoter/enhancer. The transgene promoted increased bone formation within prospective marrow space, but delayed the transition from bone to bone marrow during growth, the formation of marrow cavities, and the appearance of stromal cell types such as marrow adipocyte

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Jang, Kyoung-Je, Sujin Kim, Sangbae Park, et al. "Lithographically-Fabricated HA-Incorporated PCL Nanopatterned Patch for Tissue Engineering." Applied Sciences 10, no. 7 (2020): 2398. http://dx.doi.org/10.3390/app10072398.

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Inspired by the aligned extracellular matrix and bioceramics in human bone tissue, we investigated the relative contributions of nanotopography and equine bone powders (EBPs) with human dental pulp stem cells (DPSCs) to the osteogenesis. Both nanotopography and EBPs independently promoted the osteogenesis of DPSCs, osteogenesis was further promoted by the two factors in combination, indicating the importance of synergistic design factor of guided bone regeneration (GBR) membrane. The osteogenesis of DPSCs was affected by the polycaprolactone-based nanotopography of parallel nanogrooves as well

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Dall'Agnol, Rosiris, Marcos Brasilino de Carvalho, Abrão Rapoport, and Maria Antonieta Longo Galvão Silva. "Induction of osteogenesis by demineralized homologous and xenograft bone matrix." Acta Cirurgica Brasileira 18, no. 3 (2003): 178–82. http://dx.doi.org/10.1590/s0102-86502003000300003.

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The osteogenesis induction by demineralized bone matrix grafts remains as a challenge in the reconstructions of the mandible through homologous and xenografts or in implants in abdominal muscle. PURPOSE: Observed the behaviour of implants of demineralized bone matrix at the mandible (right side with homologous graft and left side with xenograft of pig). METHODS: Experimental study with homologous and heterologous implants of demineralized bone matrix at the mandible and in ectopic muscle at the Center of Experimental Surgery of Heliopolis Hospital, Hosphel, São Paulo, Brazil. In 6 white New Ze

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Park, Kyung-Ran, Ji Eun Park, Bomi Kim, Il Keun Kwon, Jin Tae Hong та Hyung-Mun Yun. "Calycosin-7-O-β-Glucoside Isolated from Astragalus membranaceus Promotes Osteogenesis and Mineralization in Human Mesenchymal Stem Cells". International Journal of Molecular Sciences 22, № 21 (2021): 11362. http://dx.doi.org/10.3390/ijms222111362.

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Stem cells have received attention in various diseases, such as inflammatory, cancer, and bone diseases. Mesenchymal stem cells (MSCs) are multipotent stem cells that are critical for forming and repairing bone tissues. Herein, we isolated calycosin-7-O-β-glucoside (Caly) from the roots of Astragalus membranaceus, which is one of the most famous medicinal herbs, and investigated the osteogenic activities of Caly in MSCs. Caly did not affect cytotoxicity against MSCs, whereas Caly enhanced cell migration during the osteogenesis of MSCs. Caly increased the expression and enzymatic activities of

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Fan, Jun-jun, Tian-wang Mu, Jun-jun Qin, Long Bi, and Guo-xian Pei. "Different Effects of Implanting Sensory Nerve or Blood Vessel on the Vascularization, Neurotization, and Osteogenesis of Tissue-Engineered Bone In Vivo." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/412570.

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To compare the different effects of implanting sensory nerve tracts or blood vessel on the osteogenesis, vascularization, and neurotization of the tissue-engineered bone in vivo, we constructed the tissue engineered bone and implanted the sensory nerve tracts (group SN), blood vessel (group VB), or nothing (group Blank) to the side channel of the bone graft to repair the femur defect in the rabbit. Better osteogenesis was observed in groups SN and VB than in group Blank, and no significant difference was found between groups SN and VB at 4, 8, and 12 weeks postoperatively. The neuropeptides ex

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Kriegel, Anja, Eva Langendorf, Valentina Kottmann, et al. "Bone Sialoprotein Immobilized in Collagen Type I Enhances Angiogenesis In Vitro and In Ovo." Polymers 15, no. 4 (2023): 1007. http://dx.doi.org/10.3390/polym15041007.

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Bone fracture healing is a multistep process, including early immunological reactions, osteogenesis, and as a key factor, angiogenesis. Molecules inducing osteogenesis as well as angiogenesis are rare, but hold promise to be employed in bone tissue engineering. It has been demonstrated that the bone sialoprotein (BSP) can induce bone formation when immobilized in collagen type I, but its effect on angiogenesis still has to be characterized in detail. Therefore, the aim of this study was to analyse the effects of BSP immobilized in a collagen type I gel on angiogenesis. First, in vitro analyses

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Aronson, James. "Experimental and Clinical Experience with Distraction Osteogenesis." Cleft Palate-Craniofacial Journal 31, no. 6 (1994): 473–82. http://dx.doi.org/10.1597/1545-1569_1994_031_0473_eacewd_2.3.co_2.

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G. A. Ilizarov's clinical insights and experimental biology have developed into what is known today as distraction osteogenesis. Initially used for the treatment of fractures and nonunions, his methods have proven successful for limb lengthening and bone transportation. A brief history of the development of distraction osteogenesis, definition of terms, methods, and monitoring techniques are described. The primary mechanism, intramembranous ossification, is direct bone formation in uniform gradients of mineralization from a central fibrous interzone. New bone is produced from the local host su

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Liao, Junyi, Qiang Wei, Yulong Zou, et al. "Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs)." Cellular Physiology and Biochemistry 41, no. 5 (2017): 1905–23. http://dx.doi.org/10.1159/000471945.

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Background/Aims: Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into several lineages including bone. Successful bone formation requires osteogenesis and angiogenesis coupling of MSCs. Here, we investigate if simultaneous activation of BMP9 and Notch signaling yields effective osteogenesis-angiogenesis coupling in MSCs. Methods: Recently-characterized immortalized mouse adipose-derived progenitors (iMADs) were used as MSC source. Transgenes BMP9, NICD and dnNotch1 were expressed by adenoviral vectors. Gene expression was determined by qPCR and immunohistochem¡

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Pedersen, Ulrik, Flemming Melsen, Ole Elbrønd, and Peder Charles. "Histopathology of the stapes in osteogenesis imperfecta." Journal of Laryngology & Otology 99, no. 5 (1985): 451–58. http://dx.doi.org/10.1017/s0022215100097036.

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SummaryConventional histological studies of stapes footplates from patients with osteogenesis imperfecta revealed, in nine out of 15 stapes examined, an otospongiotic-like lesion. Although the morphology of the stapedial lesion was comparable to the early otosclerotic focus, a greater structural disorganization and larger resorption spaces in osteogenesis imperfecta distinguished the two conditions. The histopathology of the stapes was related to the morphology of cortical and trabecular bone from the iliac crest. Various degrees of immature, osteogenic bony tissue were found in the iliac cres

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Shi, Yuquan, Chunyu Kong, and Yuan Li. "Resveratrol inhibits osteoporosis in mice model." Materials Express 12, no. 7 (2022): 939–47. http://dx.doi.org/10.1166/mex.2022.2231.

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Our study intends to assess whether resveratrol can ameliorate osteoporosis in mice. Ovariectomized (OVX) mice were established to measure SFRP1 level and SFRP1-siRNA was used to assess its effect on BMSCs osteogenesis. SFRP1 was significantly up-regulated in bone tissues and BMSCs of OVX mice with a gradual decrease during osteogenesis. However, it was not changed during BMSCs differentiation towards osteoclasts. SFRP1 knockdown significantly increased mineralization potentiality, elevated ALP activity and upregulated several osteoblast-specific genes. Moreover, bone loss was reduced in resve

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