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Dissertations / Theses on the topic 'OXA genes'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Otiniano, Cordova Chris Jordan, and Puma Xiomara Alisson Rivera. "Prevalencia de genes OXA, VIM e IMP en cepas de Acinetobacter baumannii resistentes a carbapenémicos del Hospital Nacional Hipólito Unanue. Agosto – diciembre 2019." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2021. https://hdl.handle.net/20.500.12672/16531.

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Acinetobacter baumannii es una bacteria oportunista causante de infecciones nosocomiales graves y multirresistentes. El principal objetivo del presente trabajo de investigación fue determinar la prevalencia de los genes OXAs, VIM e IMP en cepas de A. baumannii resistentes a carbapenémicos. Tipo de estudio observacional, descriptivo y transversal. Se analizaron 40 cepas clínicas de A. baumannii con un perfil de resistencia a carbapenémicos aislados en el Hospital Nacional Hipólito Unanue, Lima – Perú durante el período agosto a diciembre del 2019. Los métodos fenotípicos para determinar

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2

Mossakowska, Danuta Ewa Irena. "Molecular characterisation of the OXA-2 beta-lactamase." Thesis, University of Surrey, 1988. http://epubs.surrey.ac.uk/847832/.

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The DNA sequence of the gene coding for the OXA-2 beta-lactamase has been completed. The primary amino acid sequence deduced from the DNA sequence was used to study homologies with other beta-lactamases; no good homologies were observed with any class of beta-lactamase. A more detailed analysis has revealed from comparison of both primary and predicted secondary structure, that the OXA-2 beta-lactamase may be more closely related to class A enzymes. Confirmation that the OXA-2 beta-lactamase is a serine enzyme has come from the DNA sequence and the interaction with mechanism based inactivators

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3

Ali, Norryai A. "Expression and secretion of OXA-2 beta-lactamase by Streptomyces lividans." Thesis, University of Surrey, 1986. http://epubs.surrey.ac.uk/847196/.

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The OXA-2 beta-lactamase gene was first found on a conjugative plasmid R46 from a clinical isolate of Salmonella typhimurium. To test the expression and secretion of OXA-2 beta-lactamase in Streptomyces lividans a shuttle plasmid (pSU101) was created by fusing an Escherichia coli plasmid (pSU8) carrying the OXA-2 beta-lactamase gene with the S. lividans vector pLJ61. The OXA-2 beta-lactamase gene specified by the hybrid plasmid PSU101 was expressed in S. lividans, although at a lower level than in coli. Almost all the beta-lactamase activity was found in the culture supernatant of S. lividans,

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4

Lopes, Bruno Silvester. "Role of insertion sequences in the control of antibiotic resistance in Acinetobacter baumannii." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6500.

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Acinetobacter baumannii is an emerging multiresistant pathogen increasingly known to cause infections in the immuno-compromised patients. Carbapenems and colistin are considered to be the last resorts in treatment of infections involving multidrug resistant strains of A. baumannii. Resistance to carbapenems is well known due to the presence of intrinsic carbapenemase gene blaOXA-51-like, which may be governed by insertion elements, or by acquired carbapenemases like blaOXA-23-like, blaOXA-58-like or blaOXA-40-like genes, most of which are frequently associated with insertion elements. The acqu

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5

Zhang, Jinglan. "Genomic analysis of 12-oxo-phytodienoic acid reductase genes of Zea mays." Texas A&M University, 2004. http://hdl.handle.net/1969.1/3332.

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The 12-oxo-phytodienoic acid reductases (OPRs) are enzymes of the octadecanoid pathway which converts linolenic acid to a phytohormone, jasmonic acid. Bioinformatics analysis of ESTs and genomic sequences from available private and public databases revealed that the maize genome encodes eight different OPR genes. This number of maize OPR genes has been independently confirmed by Southern blot analysis and by mapping of individual OPR genes to maize chromosomes using oat maize chromosome addition lines. Survey of massively parallel signature sequencing (MPSS) assays revealed that transcripts o

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6

Bilek, Nicole. "Genetic mechanisms of opa gene variation in Neisseria gonorrhoeae." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6210.

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To understand the rates and mechanisms of Neisseria gonorrhoeae opacity (opa) gene variation, the 11 opa genes were amplified independently so that an opa allelic profile could be defined for any isolate from the sequences at each locus. Initial examination of 14 unrelated gonococcal isolates showed that no opa alleles were shared. Analysis of closely related isolates showed these typically shared most opa alleles and so the mechanisms by which recent changes occurred at individual opa loci could be determined. The great majority of changes were due to recombination among existing alleles that

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7

Callaghan, Martin John. "Evolutionary stability in the opa gene repertoire of Neisseria meningitidis." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400558.

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8

Rosa, Pamela Laiz Paré da. "Evolução dos genes da rede OXT - AVP - PRL: Aspectos moleculares, fisiológicos e comportamentais em mamíferos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/180703.

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A busca pelo repertório genético por trás de características comportamentais e reprodutivas de espécies de primatas tem desafiado nosso grupo de pesquisa. A premissa principal nesse tipo de estudo baseia-se na hipótese de que um traço fenotípico (seja ele fisiológico, comportamental, etc) compartilhado por um grupo taxonômico inteiro deve ser determinado por um repertório genético comum a esses táxons. Considerando a complexidade de muitas dessas características, temos ampliado nossos estudos para vários genes da rede OXT – AVP – PRL, usando abordagens in silico, in vitro, e in vivo. Na presen

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9

Andersson, Lina. "Tor, Ola, Leo och Elsa : - en diskursanalytisk studie av hur genus konstrueras i två läseböcker avsedda för grundskolans tidigare åldrar." Thesis, Linköping University, Department of Social and Welfare Studies, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7332.

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<p>Syftet med den här studien är att genom diskursanalys analysera hur genus konstrueras i två läseböcker avsedda för grundskolans tidigare åldrar. Vidare syftar uppsatsen till att undersöka huruvida konstruktionerna av genus i läromedlen förstärker och/eller bryter mot rådande genusstereotyper. Utgångspunkten för uppsatsen är teorier som ser genus, och vad vi uppfattar som kvinnligt och manligt, som sociala, kulturella, historiska konstruktioner, snarare än som biologiskt nedärvda, beständiga och oföränderliga egenskaper. Uppsatsen har ett diskursanalytiskt angreppssätt. Analysen syftar därme

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10

Brust, Flávia. "Detecção do gene blaOXA-23 por PCR em tempo real de aspirados traqueais de pacientes sob ventilação mecânica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/67645.

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Introdução: O gênero Acinetobacter representa um importante patógeno relacionado a infecções hospitalares, principalmente, à pneumonia associada à ventilação mecânica (PAV). O aumento de isolados de Acinetobacter baumannii resistentes aos carbapenêmicos (ABRC) representa um problema mundial, pois limita drasticamente as opções terapêuticas. A produção da carbapenamase OXA-23, uma β-lactamase da classe D de Ambler, representa o principal mecanismo responsável por esta resistência em nosso país. Objetivo: O presente estudo tem como objetivo padronizar a técnica de PCR em tempo real (qPCR) para a

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11

Rämgård, Östlund Stefan. "Två avböner & en revolt i syndarnas teater : En studie i apologia och kriskommunikation." Thesis, Uppsala universitet, Avdelningen för retorik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172854.

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12

Amorin, Bruna. "Polimorfismo V89L do gene 5 α-redutase tipo II (SRD5A2) e a associação com o risco de câncer de próstata :". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/115564.

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Introdução: A pesquisa por marcadores genéticos de susceptibilidade a doenças geralmente focam um gene baseado nas propriedades e vias metabólicas de seus produtos protéicos, assim, genes envolvidos na biossíntese de andrógenos podem identificar possíveis alterações na carcinogênese prostática. Diferenças étnicas em polimorfismos apresentam um papel no metabolismo de hormônios e podem acometer diferentes raças no risco de desenvolver câncer de próstata. A 5 alfaredutase (SRD5A2) é a enzima responsável por catalisar irreversivelmente a conversão da testosterona no principal androgênio prostátic

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13

Kitsera, Nataliya [Verfasser]. "Mechanistic study of the effects of 8-oxo-7,8-dihydroguanine (8-oxoG) on reporter gene expression in mammalian cells / Nataliya Kitsera." Mainz : Universitätsbibliothek Mainz, 2012. http://d-nb.info/1022301330/34.

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14

Andeol, Yannick. "Contribution a l'etude des oncogenes cellulaires de la famille ras : caracterisation dans trois lignees tumorales humaines." Paris 6, 1987. http://www.theses.fr/1987PA066065.

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15

Astinotti, Daniel. "Regulation de la transcription du gene de l'ovalbumine de l'oviducte de poule par les hormones steroides." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13023.

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La regulation du gene ovalbumine se fait essentiellement au niveau transcriptionnel a l'aide de construction reumbinents exprimant les genes marqueurs (antigene t du sv40, ou chloramphenicol acetyltransferase) sous controle de sequences pronostics du gene ovalbumine, il a ete trouve une unite de regulation hoemonale negative fonctionnant de facon unidirectionnelle (inhibition en presences d'antagonistes des hormones steroides de sa propre promoteur, repression du promoteur du gene ovalbumine en absence d'hormone steroide) et un motif 5'-gctcaca-3' implique dans une regulation portive du promot

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16

Rovere, Martina. "Étude fonctionnelle de la famille des facteurs de transcription ERF-VIIs chez Medicago truncatula : régulateurs clés de l’adaptation au manque d’oxygène." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4037/document.

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Les légumineuses sont connues pour leurs capacités à établir une relation symbiotique avec des bactéries du sol fixatrices de l'azote atmosphérique. Cette interaction aboutit à la formation d'un nouvel organe au niveau des racines, la nodosité, au sein duquel le symbiote convertit l'azote atmosphérique (N2) en ammoniac, qui peut être directement consommé par les plantes. A l’intérieur de cette nodosité, la concentration en oxygène (O2) est maintenue à un très faible niveau car la réaction de réduction du N2 par l’enzyme bactérienne nitrogénase est inhibée par des traces d’oxygène. Un mécanisme

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17

Rovere, Martina. "Étude fonctionnelle de la famille des facteurs de transcription ERF-VIIs chez Medicago truncatula : régulateurs clés de l’adaptation au manque d’oxygène." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4037.

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Les légumineuses sont connues pour leurs capacités à établir une relation symbiotique avec des bactéries du sol fixatrices de l'azote atmosphérique. Cette interaction aboutit à la formation d'un nouvel organe au niveau des racines, la nodosité, au sein duquel le symbiote convertit l'azote atmosphérique (N2) en ammoniac, qui peut être directement consommé par les plantes. A l’intérieur de cette nodosité, la concentration en oxygène (O2) est maintenue à un très faible niveau car la réaction de réduction du N2 par l’enzyme bactérienne nitrogénase est inhibée par des traces d’oxygène. Un mécanisme

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18

Simonneau, Lionel. "Etude de l'expression des cristallines et de leurs proprietes aggregatives dans les cultures de cellules epitheliales de cristallin de boeuf et de la neurotine embryonnaire de caille normale ou transformee par des retrovirus aviaires." Paris 7, 1988. http://www.theses.fr/1988PA077154.

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19

Konstantinidou, Valentini. "Molecular mechanisms involved in the protective effect of Mediterranean diet and olive oil consumption in humans." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7208.

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The scope of the present work was to investigate whether the protective role of the traditional Mediterranean diet (TMD), and virgin olive oil (VOO) rich in phenolic compounds (PC), towards cardiovascular disease can be mediated through gene expression changes. Two trials were performed to assess the in vivo nutrigenomic effects of TMD and VOO in healthy volunteers. The results point out: a) significant gene expression changes of those genes related with cardiovascular-risk processes after VOO ingestion; b) a down-regulation in the expression of atherosclerosis-related genes after a 3-month in

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20

Yang-Sheng and 蔡仰陞. "Genotyping of OXA carbapenemases genes of Multidrug Resistant Acinetobacter baumannii Isolates." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/56467600818788028945.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>97<br>The emergence and rapid spread of the important nosocomial pathogens drug-resistant Acinetobacter spp., in particular Acinetobacter baumannii (A. baumannii), are of great concern worldwide. More than half of the drug-resistant Acinetobacter spp. are resistant to at least 3 classes of antibiotics, and designated as multidrug-resistant (MDR) Acinetobacter spp.. The antimicrobial agent carbapenems have been relied upon for treating infections caused by MDR A. baumannii. However, carbapenems resistance in Acinetobacter spp. is particularly a significant public

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21

黃韋強. "The effect of electroporation on OVA or IL-12 genes administration." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/06611002085886101455.

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碩士<br>長庚大學<br>基礎醫學研究所<br>91<br>T helper cells are divided into two sub-populations, T helper 1 (TH1) and T helper 2 (TH2). TH1 cells can produce interleukin (IL)-2 and interferon (IFN)-γ; contrastly, TH2 cells predominantly produce IL-4, IL-5, IL-10 and IL-13. Each cytokine has its distinct functions in regulating immune responses, and interferes each other. IL-12 is one of them and it’s a heterodimer protein composed of two subunits of 35 and 40 kDa. It enhances the production of IFN-γ, and subsequently stimulates naive T cells to differentiate into TH1 cells. Because many diseases are caused

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22

Gaspar, Laetitia da Silva. "Clock genes profile as disease biomarkers." Master's thesis, 2016. http://hdl.handle.net/10316/33820.

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Dissertação de Mestrado em Biologia Celular e Molecular, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.<br>Circadian rhythms, defined by a set of biological clocks, are crucial to virtually all biological processes. A central clock is located in the hypothalamus and synchronises peripheral clocks, located in all cells. Disruptions in this complex circadian clock system, reflected by clock gene expression alterations, is associated with several diseases. Obstructive sleep apnea (OSA) is one of the most common sleep disorders

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23

Su, Hsiao-Chiao, and 蘇筱喬. "The modulatory effect of IL-10 and IL-12 genes on immune cells and OVA-induced asthmatic mice." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/80153149791803769908.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>96<br>The T helper type 2 cells (Th2) play a curial role in the initiation of allergic asthma. Asthma is characterized by reversible airway obstruction, eosinophilic infiltration, airway remodeling, mucus hypersecretion and airway hyperresponsiveness. In our studies, we use IL-10 or IL-12 expessing adenoviral vector to observe whether combination treatment can suppress the airway inflammation of allergic asthma. Firstly, we applied the Ad-IL-10/IL-12 to the bone marrow derived dendritic cells (DCs) and found such modified DCs expressed increased surface makers of CD

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24

Charbonneau, Annie. "Isolement et caractérisation des gènes de la 5[bêta]-réductase humaine ainsi que de la 17B-hydroxystéroïde déshydrogénase de type 5 de souris /." 2000. http://proquest.umi.com/pqdweb?did=727198081&sid=19&Fmt=2&clientId=9268&RQT=309&VName=PQD.

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Wu, Chia-Mao, and 吳嘉茂. "Mouse PKC-alpha gene as target: a study of foldback triplex formation with 8-oxo-adenine and 5-methyl cytosine modified oligonucleotides." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/73490171305755458468.

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碩士<br>國立中興大學<br>生物化學研究所<br>87<br>Protein kinase C (PKC) plays a central role in the cell signal transductions. Evidences have shown that tumor genesis is triggered by overproduction of PKC. Thus studies the control of PKC gene expression becomes an important goal. There is a purine rich segment, GGGGGGAA, in the upstream region of mouse PKC-gene. That can be used to block the PKC- gene expression by triplex formation. “Foldback Triplex Formation Oligonucleotides”(FTFOs), linear oligonucleotides that bind to single-stranded nucleic acid targets by formation of both Watson-Crick (duplex) and

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