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Journal articles on the topic 'OXA genes'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Higgins, Paul G., Francisco J. Pérez-Llarena, Esther Zander, Ana Fernández, Germán Bou та Harald Seifert. "OXA-235, a Novel Class D β-Lactamase Involved in Resistance to Carbapenems in Acinetobacter baumannii". Antimicrobial Agents and Chemotherapy 57, № 5 (2013): 2121–26. http://dx.doi.org/10.1128/aac.02413-12.

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ABSTRACTWe investigated the mechanism of carbapenem resistance in 10Acinetobacter baumanniistrains isolated from the United States and Mexico between 2005 and 2009. The detection of known metallo-β-lactamase or carbapenem-hydrolyzing oxacillinase (OXA) genes by PCR was negative. The presence of plasmid-encoded carbapenem resistance genes was investigated by transformation ofA. baumanniiATCC 17978. Shotgun cloning experiments and sequencing were performed, followed by the expression of a novel β-lactamase inA. baumannii. Three novel OXA enzymes were identified, OXA-235 in 8 isolates and the ami

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Towner, Kevin J., Benjamin Evans, Laura Villa та ін. "Distribution of Intrinsic Plasmid Replicase Genes and Their Association with Carbapenem-Hydrolyzing Class D β-Lactamase Genes in European Clinical Isolates of Acinetobacter baumannii". Antimicrobial Agents and Chemotherapy 55, № 5 (2011): 2154–59. http://dx.doi.org/10.1128/aac.01661-10.

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ABSTRACTNinety-six genetically diverse multidrug-resistant clinical isolates ofAcinetobacter baumanniifrom 25 hospitals in 17 European countries were screened by PCR for specific carbapenemase-hydrolyzing class D β-lactamase (CHDL) genes and by PCR-based replicon typing for the presence of 19 different plasmid replicase (rep) gene homology groups (GRs). Results were confirmed by DNA sequencing where necessary. All 96 isolates contained at least 1 (with a maximum of 4) of the 19 groups ofrepgenes. Groups detected were GR6 (repAci6; 93 isolates), GR2 (includingrepAci1 [67 isolates] andrepAci2 [3

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3

Poirel, Laurent, Samy Figueiredo, Vincent Cattoir, Alessandra Carattoli, and Patrice Nordmann. "Acinetobacter radioresistens as a Silent Source of Carbapenem Resistance for Acinetobacter spp." Antimicrobial Agents and Chemotherapy 52, no. 4 (2008): 1252–56. http://dx.doi.org/10.1128/aac.01304-07.

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ABSTRACT Carbapenem resistance results mostly from the expression of acquired carbapenem-hydrolyzing oxacillinases in Acinetobacter baumannii. The bla OXA-23 oxacillinase gene is increasingly reported worldwide and may represent an emerging threat. Our goal was to identify the progenitor of that carbapenemase gene. A collection of 50 Acinetobacter sp. strains corresponding to several Acinetobacter species was screened for bla OXA-23-like genes by PCR and hybridization techniques. Five Acinetobacter radioresistens isolates that were susceptible to carbapenems harbored chromosomally encoded bla

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Héritier, Claire, Laurent Poirel, Thierry Lambert, and Patrice Nordmann. "Contribution of Acquired Carbapenem-Hydrolyzing Oxacillinases to Carbapenem Resistance in Acinetobacter baumannii." Antimicrobial Agents and Chemotherapy 49, no. 8 (2005): 3198–202. http://dx.doi.org/10.1128/aac.49.8.3198-3202.2005.

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ABSTRACT Carbapenem-hydrolyzing oxacillinases are reported increasingly in Acinetobacter baumannii. Since they hydrolyze carbapenems at low levels, the roles of carbapenem-hydrolyzing oxacillinases OXA-23, OXA-40, and OXA-58 in A. baumannii were determined. The bla OXA-23, bla OXA-40, and bla OXA-58 genes were inserted in broad-host-range plasmid pAT801 and transformed in Escherichia coli DH10B and in A. baumannii CIP 70.10 and its point mutant derivative A. baumannii BM4547, which overexpresses the efflux pump AdeABC. Natural plasmids harboring the bla OXA-23 and bla OXA-58 genes were also tr

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Tacão, Marta, Isabel Silva, and Isabel Henriques. "Culture-independent methods reveal high diversity of OXA-48-like genes in water environments." Journal of Water and Health 15, no. 4 (2017): 519–25. http://dx.doi.org/10.2166/wh.2017.260.

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The carbapenemase OXA-48 was identified for the first time in 2001 and is now one of the greatest concerns in terms of antibiotic resistance. While many studies report clinical OXA-48-like producers, few reports refer blaOXA-48-like genes in environmental bacteria. The main goal of this study was to evaluate the diversity of blaOXA-48-like genes in aquatic systems, using culture-independent approaches. For that, environmental DNA was obtained from riverine and estuarine water and used to construct clone libraries of blaOXA-48-like gene polymerase chain reaction amplicons. blaOXA-48-like librar

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6

Sarwar, Amna, Syeda Zahra Gillani, Rana Muhammad Shahbakht та ін. "Detection of Β-Lactamase OXA Genes and Biofilm Production in Carbapenem Resistant Gram-Negative Bacilli". Pakistan Journal of Medical and Health Sciences 17, № 4 (2023): 235–38. http://dx.doi.org/10.53350/pjmhs2023174235.

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Objectives: The emergence of carbapenem resistance in biofilm producer Gram-negative bacteria poses a substantial challenge to manage infections. This study aimed to evaluate biofilm production and molecular characterization of carbapenem resistance Gram-negative rods. Methods: Total of 46 bacteria were isolated from various clinical samples, including blood, CSF, urine, sputum, saliva, tracheal secretion, and pus. Following the standard guidelines for bacterial identification (CLSI), bacterial pathogens are isolated and identified. The antibiotic susceptibility profile was obtained against co

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Karabay, Osman, Fahriye Ekşi, Mehmet Sait Yıldırım, and Deniz Gazel. "Investigation of Antibiotic Resistance Profiles and Carbapenemase Resistance Genes in Acinetobacter Baumannii Strains Isolated From Clinical Samples." European Journal of Therapeutics 28, no. 4 (2022): 252–59. http://dx.doi.org/10.58600/eurjther-28-4-0071.

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Objective: Acinetobacter baumannii is an important pathogen that can develop multiple drug resistance. Here, we aimed to investigate the antibiotic resistance profiles of A. baumannii strains isolated from the various clinics of our hospital and determine the class D beta-lactamase resistance genes causing carbapenem resistance. Methods: Between June-2016 and June-2017, 157 A. baumannii strains isolated from clinical specimens of our hospital were identified with automatic bacterial identification system and antibiograms were determined by the same system. Among the carbapenem resistant strain

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L. Aishwarya, K. V., P. V. Geetha, M. Shanthi, and S. Uma. "Co occurrence of two 16S rRNA methyltrasferases along with NDM and OXA 48 like carbapenamases on a single plasmid in Klebsiella pneumoniae." Journal of Laboratory Physicians 11, no. 04 (2019): 305–11. http://dx.doi.org/10.4103/jlp.jlp_59_19.

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Abstract BACKGROUND: The carbapenemase-encoding genes, bla NDM- and bla OXA-48 - like , confer resistance to all the known beta-lactams and are encountered along with other beta-lactamase-encoding genes and/or 16S ribosomal RNA (rRNA)-methylating genes. The co-occurrence of bla NDM and bla OXA-48 - like on a single plasmid is a rare occurrence. AIM AND OBJECTIVE: The purpose of the study was to characterize the plasmids in Klebsiella pneumoniae isolates producing 16S rRNA methyltransferase along with bla NDM , bla OXA-48-like , and other resistance encoding genes. MATERIALS AND METHODS: One-hu

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Gur, Deniz, Volken Korten, Serhat Unal, Lalitagauri M. Deshpande, and Mariana Castanheira. "Increasing carbapenem resistance due to the clonal dissemination of oxacillinase (OXA-23 and OXA-58)-producing Acinetobacter baumannii: report from the Turkish SENTRY Program sites." Journal of Medical Microbiology 57, no. 12 (2008): 1529–32. http://dx.doi.org/10.1099/jmm.0.2008/002469-0.

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A significant increase in carbapenem-resistance rates among Acinetobacter baumannii isolates collected in two Turkish medical centres was detected in the 2000–2006 period (20–60 %) by the SENTRY Antimicrobial Surveillance Program. Carbapenem-resistant strains from 2006 were evaluated for the presence of encoding genes and epidemic clonality. OXA-58-like and OXA-23-like carbapenemase-producing strains were detected in both medical institutions. Seventeen out of 18 strains from Ankara were positive for bla OXA-58 primers and belonged to the same clone, whilst 26 isolates (25 from Istanbul and on

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Wang, Hui, Ping Guo, Hongli Sun, et al. "Molecular Epidemiology of Clinical Isolates of Carbapenem-Resistant Acinetobacter spp. from Chinese Hospitals." Antimicrobial Agents and Chemotherapy 51, no. 11 (2007): 4022–28. http://dx.doi.org/10.1128/aac.01259-06.

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ABSTRACT Carbapenem resistance in Acinetobacter spp. is an emerging problem in China. We investigated the molecular epidemiology and carbapenemase genes of 221 nonrepetitive imipenem-resistant clinical isolates of Acinetobacter spp. collected from 1999 to 2005 at 11 teaching hospitals in China. Genotyping by pulsed-field gel electrophoresis (PFGE) found 15 PFGE patterns. Of these, one (clone P) was identified at four hospitals in Beijing and another (clone A) at four geographically disparate cities. Most imipenem-resistant isolates exhibited high-level resistance to all β-lactams and were only

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11

Zafer, Mai M., Mohamed H. Al-Agamy, Hadir A. El-Mahallawy, Magdy A. Amin, and Mohammed Seif El-Din Ashour. "Antimicrobial Resistance Pattern and Their Beta-Lactamase Encoding Genes amongPseudomonas aeruginosaStrains Isolated from Cancer Patients." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/101635.

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This study was designed to investigate the prevalence of metallo-β-lactamases (MBL) and extended-spectrumβ-lactamases (ESBL) inP. aeruginosaisolates collected from two different hospitals in Cairo, Egypt. Antibiotic susceptibility testing and phenotypic screening for ESBLs and MBLs were performed on 122P. aeruginosaisolates collected in the period from January 2011 to March 2012. MICs were determined. ESBLs and MBLs genes were sought by PCR. The resistant rate to imipenem was 39.34%. The resistance rates forP. aeruginosato cefuroxime, cefoperazone, ceftazidime, aztreonam, and piperacillin/tazo

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12

Farajzadeh, Anahita, Mohsen Mirzaee, Shahram Nanekarani, and Reza Yari. "Application of Multiplex PCR for the Identification of Oxacillinase Genes and Determination of Antibiotic Resistance Pattern in Environmental Isolates of Acinetobacter baumannii in ICU." Avicenna Journal of Clinical Microbiology and Infection 8, no. 3 (2021): 89–93. http://dx.doi.org/10.34172/ajcmi.2021.16.

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Background: Acinetobacter baumannii is a common cause of nosocomial infections. A prominent feature of these bacteria is resistance to carbapenems. This study aimed to identify OXA genes encoding oxacillinase in Acinetobacter baumannii isolates. Methods: This cross-sectional descriptive study was performed on 25 environmental A. baumannii isolates collected from ICU over 8 months. Definitive identification of isolates was performed by biochemical tests and polymerase chain reaction (PCR) of 16s rRNA gene. Antibiotic susceptibility testing was performed on Müller-Hinton agar medium by disk diff

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13

Syromyatnikov, M. Yu, S. V. Shabunin, E. Yu Nesterova, et al. "ANALYSIS OF ANTIBIOTIC RESISTANCE GENES OF ESCHERICHIA COLI FROM THE GUT OF THE PIGLETS WITH DIARRHEA." Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine 60, no. 2 (2024): 95–100. http://dx.doi.org/10.52368/2078-0109-2024-60-2-95-100.

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The study is devoted to the analysis of the prevalence of antibiotic resistance genes in cultures of E. coli isolated from the gut of the piglets with diarrhea. With the use of high-throughput sequencing, it was possible to identify 26 antibiotic resistance genes. They belonged to 7 groups of antibiotics: aminoglycosides, beta-lactam antibiotics, quinolones, sulfonamides, tetracyclines, diaminopyrimidine, phenicols. The relative abundance of the QnrD gene was maximal in the studied sample of E. coli isolates (50%). For other sequences of antibiotic resistance genes, the percentage ratio of eac

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14

Héritier, Claire, Laurent Poirel, Pierre-Edouard Fournier, Jean-Michel Claverie, Didier Raoult, and Patrice Nordmann. "Characterization of the Naturally Occurring Oxacillinase of Acinetobacter baumannii." Antimicrobial Agents and Chemotherapy 49, no. 10 (2005): 4174–79. http://dx.doi.org/10.1128/aac.49.10.4174-4179.2005.

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ABSTRACT A chromosomally encoded oxacillinase, OXA-69, was characterized from Acinetobacter baumannii AYE. β-Lactamase OXA-69 shared 97% amino acid identity with the recently described OXA-51 enzyme of A. baumannii and 62 and 56% amino acid identity with the carbapenem-hydrolyzing oxacillinases OXA-24 and OXA-23, respectively. Biochemical characterization of the purified OXA-69 revealed a narrow-spectrum hydrolysis profile but including, at a low level, imipenem and meropenem. By PCR and sequencing bla OXA-69-like genes were identified in all A. baumannii strains tested (n = 12), suggesting th

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Tian, Guo-Bao, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, et al. "Identification of Diverse OXA-40 Group Carbapenemases, Including a Novel Variant, OXA-160, fromAcinetobacter baumanniiin Pennsylvania." Antimicrobial Agents and Chemotherapy 55, no. 1 (2010): 429–32. http://dx.doi.org/10.1128/aac.01155-10.

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ABSTRACTThreeAcinetobacter baumanniiisolates that possess OXA-40 group carbapenemase genes were identified. They belonged to novel sequence types (ST122, ST123, and ST124) and harboredblaOXA-160,blaOXA-72, andblaOXA-40, respectively. OXA-160 is a novel variant of OXA-40 with a P227S substitution. An isogenicEscherichia coliclone producing OXA-160 was more susceptible to carbapenems than a clone producing OXA-40. The genetic environment ofblaOXA-160andblaOXA-40beyond the putative XerC/XerD recombination sites was distinct from the scaffold reported previously.

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Kryzhanovskaya, O. A., A. V. Lazareva, I. V. Chebotar, Yu A. Bocharova, and N. A. Mayansky. "SPECTRUM OF ANTIBIOTIC RESISTANCE AND PREVALENCE OF OXA-CARBAPENEMASES AMONG ACINETOBACTER BAUMANNII STRAINS, ISOLATED FROM PATIENTS OF SURGICAL AND REANIMATION DEPARTMENTS IN MOSCOW." Journal of microbiology epidemiology immunobiology, no. 1 (February 28, 2016): 40–45. http://dx.doi.org/10.36233/0372-9311-2016-1-40-45.

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Aim. Characterize spectrum of antibiotics resistance of Acinetobacter baumannii strains, isolated from patients of 8 surgical and reanimation departments of 3 medical institution of Moscow, and determine molecular-genetic mechanisms of stability of their carbapenem-resistant forms. Materials and methods. 95 strains of A. baumannii, isolated from patients of reanimation and surgical departments of Moscow in 2012 - 2014, were studied. Sensitivity of strains to antibiotics was tested phenotypically according to recommendations of EUCAST. The presence ofVIM, IMP, OXA-23, OXA-40, OXA-48, OXA-58 and

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Yanovich, O. O., and L. P. Titov. "Prevalence of serine carbapenemase genes among multi-resistant strains of Klebsiella pneumoniae isolated from patients in the departments of surgery and intensive care units." Doklady of the National Academy of Sciences of Belarus 68, no. 2 (2024): 148–55. http://dx.doi.org/10.29235/1561-8323-2024-68-2-148-155.

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The frequency of serine carbapenemases in phenotypically multi-drug resistant K. pneumoniae obtained from patients of surgery and intensive care units in Belarus was assessed. Beta-lactamase genes KPC, OXA-48, OXA-23, and OXA-24 were detected by PCR in 115 phenotypically multi-drug resistant K. pneumoniae. The most common carbapenemase gene was blaOXA-48 (70 %). The genes KPC and blaOXA-24 were identified in 43.6 and 39.1 % isolates, respectively. Single serine carbapenemase gene was detected in 23.5 % strains. On other strains, the molecular analysis determined double or triple carbapenemase

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Nordmann, Patrice, Laurent Poirel, Maryline Kubina, Anne Casetta та Thierry Naas. "Biochemical-Genetic Characterization and Distribution of OXA-22, a Chromosomal and Inducible Class D β-Lactamase fromRalstonia (Pseudomonas)pickettii". Antimicrobial Agents and Chemotherapy 44, № 8 (2000): 2201–4. http://dx.doi.org/10.1128/aac.44.8.2201-2204.2000.

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ABSTRACT From genomic DNA of Ralstonia pickettii isolate PIC-1, a β-lactamase gene was cloned that encodes the oxacillinase OXA-22. It differs from known oxacillinases, being most closely related to OXA-9 (38% amino acid identity). The hydrolytic spectrum of OXA-22 is limited mostly to benzylpenicillin, cloxacillin, and restricted-spectrum cephalosporins. OXA-22-like genes were identified as single chromosomal copies in five other R. pickettii clinical isolates. The expression of OXA-22-like β-lactamases was inducible in R. pickettii.

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Beyrouthy, R., F. Robin, J. Delmas, et al. "IS1R-Mediated Plasticity of IncL/M Plasmids Leads to the Insertion ofblaOXA-48into the Escherichia coli Chromosome." Antimicrobial Agents and Chemotherapy 58, no. 7 (2014): 3785–90. http://dx.doi.org/10.1128/aac.02669-14.

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ABSTRACTThe OXA-48 carbapenemase is mainly encoded by ∼62-kb IncL/M plasmids. However, chromosome-mediated genes have been observed inEscherichia coliisolates. In this work, we investigated the genetic environment of OXA-48 in members of the familyEnterobacteriaceae(n= 22) to understand how the OXA-48-encoding gene is transferred into theE. colichromosome. The OXA-48-encoding gene was located within intact Tn1999.2transposons in the ∼62-kb plasmids or within a truncated variant of Tn1999.2for the OXA-48-encoding genes located in the chromosomes ofE. colibacteria. The analysis of the Tn1999.2ge

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. AL-Kaisse, Asmaa A., Amina N. AL-Thwani, and Rabab Q. AL-Segar. "PCR Detection of Some ESBLs (bla) Genes in Pseudomonas aeruginosa Isolated from Burn’s Units in Bagdad Hospitals." Journal of Biotechnology Research Center 9, no. 2 (2015): 74–80. http://dx.doi.org/10.24126/jobrc.2015.9.2.439.

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Multi drug resistant (MDR) and Extended Spectrum Beta Lactamase (ESBLs) of Pseudomonas aeruginosawere detected. Pseudomonas aeruginosa is a bacterium responsible for severe infections in burn’s units,plasmid DNA analysis and encoded many types of genes responsible for beta-lactamases. To determine thetype of genes responsible for beta-lactam broad spectrum in P. aeruginosa strains isolated from 100 swabsof burn’s units environment, using a molecular methods (PCR) by primers specific to ESBLs (bla ) genesoxacillin hydrolyzing capabilities OXA-10, OXA-4 and Vietnam Extended-Spectrum β-Lactame VE

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Lopes, B. S., A. Hamouda, J. Findlay, and S. G. B. Amyes. "Effect of frameshift mutagen acriflavine on control of resistance genes in Acinetobacter baumannii." Journal of Medical Microbiology 60, no. 2 (2011): 211–15. http://dx.doi.org/10.1099/jmm.0.025544-0.

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Acinetobacter baumannii is a Gram-negative pathogenic bacterium that often exhibits a multidrug-resistant phenotype causing infections at various sites of the body and increasingly leading to septicaemic shock. This study evaluated the role of acriflavine, a frameshift mutagen, on the movement of insertion sequence ISAba1 in clinical isolates of A. baumannii, with the focus on changes in expression levels of the bla ADC and bla OXA-51-like genes. Resistance profiles were assessed with consideration of ISAba1 acting as a promoter upstream of the bla ADC or bla OXA-51-like gene. ISAba1 movement

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Doi, Yohei, Laurent Poirel, David L. Paterson та Patrice Nordmann. "Characterization of a Naturally Occurring Class D β-Lactamase from Achromobacter xylosoxidans". Antimicrobial Agents and Chemotherapy 52, № 6 (2008): 1952–56. http://dx.doi.org/10.1128/aac.01463-07.

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ABSTRACT A chromosomally encoded class D β-lactamase, OXA-114, was characterized from Achromobacter xylosoxidans strain CIP69598. β-Lactamase OXA-114 shared 56% amino acid identity with the naturally occurring class D β-lactamase of Burkholderia cenocepacia and 42% identity with the acquired oxacillinases OXA-9 and OXA-18. OXA-114 has a narrow-spectrum hydrolysis profile, although it includes imipenem, at a very low level. PCR and sequencing revealed that bla OXA-114-like genes were identified in all A. xylosoxidans strains tested (n = 5), indicating that this β-lactamase is naturally occurrin

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Girlich, Delphine, Thierry Naas та Patrice Nordmann. "Regulation of class D β-lactamase gene expression in Ralstonia pickettii". Microbiology 152, № 9 (2006): 2661–72. http://dx.doi.org/10.1099/mic.0.29027-0.

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Ralstonia pickettii, an environmental bacterium that may also be responsible for human infections, produces two unrelated, inducible and chromosomally encoded oxacillinases, OXA-22 and OXA-60. In order to study the molecular basis of the induction process of these oxacillinase genes, the induction kinetics, the promoter/operator regions necessary for expression and induction, and the role of several ORFs located upstream and downstream of the bla OXA genes were investigated. The β-lactamase production reached a maximal level after 1 h induction, returned to its basal level within the following

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Pawar, Satyajeet K., Shivaji T. Mohite, Kailash D. Datkhile, Madhavi N. Patil, and Satish V. Kakade. "Rising Threat of OXA-48 and other Carbapenemase Encoding Genes among Carbapenem Resistant Enterobacteriaceae in India." Journal of Pure and Applied Microbiology 14, no. 3 (2020): 1917–25. http://dx.doi.org/10.22207/jpam.14.3.30.

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Members of Enterobacteriaceae family are responsible for both community and hospital acquired infections. Because of development of antimicrobial resistance carbapenem has remained as last resort of drug for treatment of infections caused by these bacteria.Mechanism for development of this resistance in carbapenem resistant Enterobacteriaceae (CRE) may due to production of carbapenemases, efflux mechanism or loss of outer membrane porins.The most common carbapenemase enzymes are Class A – KPC, Class B – NDM, VIM and IMP and Class D oxacillinase(OXA-48 like enzymes).In India, most prevalent car

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Kim, Young Ah, Seok Hoon Jeong, Jong Hee Shin, et al. "Four genotypes of carbapenem-resistant Acinetobacter baumannii strains lacking OXA-23 production in Korea." Annals of Clinical Microbiology 27, no. 2 (2024): 143–47. http://dx.doi.org/10.5145/acm.2024.27.2.8.

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During nationwide Fantimicrobial surveillance (Korea Global Antimicrobial Resistance Surveillance System [Kor-GLASS]), the recent emergence of non-oxacillinase (OXA)23 production by carbapenem-resistant Acinetobacter baumannii (CRAB) isolates was noted. In this study, we evaluated resistance mechanisms other than OXA-23 production to elucidate the shift in considerable CRAB clones. The presence of OXA carbapenemase genes, such as blaOXA-23 , blaOXA-24 , blaOXA-58 , and blaOXA-51-ISAba1, was determined by PCR. Other carbapenemase genes, such as blaIMP , blaVIM , blaNDM , blaKPC , blaGES , and b

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Li, Zhouxun, Chunyan Wu, Xuemei Cai, et al. "Characterization of OXA232-Producing Carbapenem-Resistant Klebsiella pneumoniae: Genomic Analysis and Virulence Assessment." Polish Journal of Microbiology 74, no. 1 (2025): 82–94. https://doi.org/10.33073/pjm-2025-007.

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Abstract Globally, the infection rate of carbapenem-resistant Klebsiella pneumoniae (CRKP) producing OXA-48-like carbapenemase is increasing, posing a significant public health threat due to its high antibiotic resistance. Between December 2019 and April 2023, ten CRKP strains carrying the OXA-48-like carbapenemase were isolated from inpatients at the First Affiliated Hospital of Kunming Medical University. Wholegenome sequencing (WGS) revealed that all strains carried the OXA-232 gene, a variant of OXA-48-like, located on the non-conjugative ColKP3 plasmid. Sequence typing identified nine str

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Alsuof, Eman Abdullah, Ahmad R. Alsayed, Manar Saleh Zraikat, et al. "Molecular Detection of Antibiotic Resistance Genes Using Respiratory Sample from Pneumonia Patients." Antibiotics 14, no. 5 (2025): 502. https://doi.org/10.3390/antibiotics14050502.

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Introduction/Objectives: Antibiotic resistance makes the treatment of pneumonia challenging. Effective management depends on accurate diagnostic techniques to identify resistance genes and customize drugs. This study primarily aimed to identify antibiotic resistance genes in respiratory samples from patients with pneumonia using polymerase chain reaction (PCR) to determine the prevalence of specific resistance genes and analyze clinical factors contributing to antibiotic resistance, as well as to provide actionable insights into resistance patterns in Jordan and support efforts to improve pneu

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Aksentijevic, Ksenija, Jelena Asanin, Jakov Nisavic, Maja Markovic, Dubravka Milanov, and Dusan Misic. "Antibiotic resistance in bacteria isolated from fish in Serbia." Veterinarski glasnik 71, no. 1 (2017): 24–34. http://dx.doi.org/10.2298/vetgl170329005a.

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Introduction. Bacteria isolated from skin, gills, and fish intestines from aquaculture ponds, ornamental fish stores/aquariums and live fish markets were investigated. Materials and Methods. Disk diffusion and E-test were used for susceptibility testing to carbapenems, ureidopenicillins with or without ?-lactamase inhibitor, 3rd and 4th generation cephalosporins, aminoglycosides, colistin, fluoroquinolones, and chloramphenicol. PCR was used to detect resistance genes in the bacterial isolates. Results and Conclusions. Among the total number of bacteria tested, regardless of the genus and speci

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Pfeifer, Yvonne, Kathrin Schlatterer, Elisabeth Engelmann, et al. "Emergence of OXA-48-Type Carbapenemase-Producing Enterobacteriaceae in German Hospitals." Antimicrobial Agents and Chemotherapy 56, no. 4 (2012): 2125–28. http://dx.doi.org/10.1128/aac.05315-11.

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ABSTRACTNine carbapenem-resistantEnterobacteriaceaeisolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999(truncated or not by IS1R) was located upstream of theblaOXA-48andblaOXA-162genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producingKlebsiella pneumoniaestrain in two hosp

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Melgarejo-Touchet, Nancy, Cristina Mariel Brítez, Sofía Busignani, et al. "Caracterización molecular de carbapenemasas en bacilos gramnegativos circulantes en hospitales de Paraguay. Primer cuatrimestre 2021." Memorias del Instituto de Investigaciones en Ciencias de la Salud 19, no. 2 (2021): 49–58. http://dx.doi.org/10.18004/mem.iics/1812-9528/2021.019.02.49.

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La resistencia a los antimicrobianos (RAM), representa un grave problema por el uso indiscriminado de antimicrobianos de amplio espectro. En nuestro país, durante el primer cuatrimestre del año, se observó un aumento inusual en el número de aislamiento de gérmenes multirresistentes, sobre todo de bacilos gramnegativos, los cuales fueron remitidos al laboratorio de referencia con el objetivo de caracterizar los genes de resistencia a los carbapenemes. Estudio observacional y prospectivo de corte transversal en 456 aislamientos de bacilos gramnegativos provenientes de 11 centros colaboradores de

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Pawłowska, Iwona, Grzegorz Ziółkowski, Estera Jachowicz-Matczak, Michał Stasiowski, Mateusz Gajda, and Jadwiga Wójkowska-Mach. "Colonization and Healthcare-Associated Infection of Carbapenem-Resistant Enterobacteriaceae, Data from Polish Hospital with High Incidence of Carbapenem-Resistant Enterobacteriaceae, Does Active Target Screening Matter?" Microorganisms 11, no. 2 (2023): 437. http://dx.doi.org/10.3390/microorganisms11020437.

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The objective of the study was to analyse the incidence of carbapenem-resistant Enterobacteriaceae (CRE) at a provincial hospital from 2019–2021. Multiplex PCR was used to detect the presence of carbapenemase genes. There were 399 cases of CRE detected in total in the analysed period, including 104 healthcare-associated infections. Out of the isolated CRE, 97.7% were Klebsiella pneumoniae with OXA-48 or KPC genes. Overall, among the identified CRE genes, the most frequently present genes were the ones mediating oxacillinase OXA-48 (71%) and KPC (26%), and significantly less often New Delhi NDM

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Girlich, Delphine, Thierry Naas та Patrice Nordmann. "OXA-60, a Chromosomal, Inducible, and Imipenem-Hydrolyzing Class D β-Lactamase from Ralstonia pickettii". Antimicrobial Agents and Chemotherapy 48, № 11 (2004): 4217–25. http://dx.doi.org/10.1128/aac.48.11.4217-4225.2004.

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ABSTRACT A chromosomally encoded oxacillinase, OXA-22, had been characterized from Ralstonia pickettii PIC-1 that did not explain by itself the resistance profile of this strain to β-lactams. Thus, further analysis of the genetic background of this species led to the identification of another oxacillinase, OXA-60, that was expressed only after β-lactam induction. This chromosomally encoded oxacillinase shared 19% amino acid identity with OXA-22. It has a narrow-spectrum hydrolysis profile that includes imipenem. OXA-60-like enzymes were identified in several R. pickettii strains. Gene inactiva

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Ciftci, Esra, Emel Sesli Cetin, Ebru Us, Hüseyin Haydar Kutlu, and Buket Cicioglu Arıdogan. "Investigation of Carbapenem resistance mechanisms in Klebsiella pneumoniae by using phenotypic tests and a molecular assay." Journal of Infection in Developing Countries 13, no. 11 (2019): 992–1000. http://dx.doi.org/10.3855/jidc.10783.

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Introduction: The aim of this study was to investigate the presence of carbapenemase production and carbapenem resistance mechanisms in 47 carbapenem resistant Klebsiella pneumoniae isolates by phenotypic confirmatory tests and molecular assay. Methodology: Carbapenem resistance genes KPC, OXA-48 and NDM were investigated with the BD MAX CRE assay kit in the BD MAX real time PCR instrument. Modified Hodge test, MBL gradient strip test, D70C Carbapenemase Detection Set, Temocillin gradient strip test methods were used as phenotypic confirmatory tests. Clonal relationship between study iso

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Uzunöner, Yasemin, Nilgün Kansak, and Sebahat Aksaray. "Investigation of the synergistic effect of ceftazidime-avibactam and aztreonam combination on carbapenem-resistant Klebsiella pneumoniae isolates with 3 different methods." Acta Microbiologica et Immunologica Hungarica 71, no. 4 (2024): 308–14. https://doi.org/10.1556/030.2024.02395.

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AbstractTreatment options are limited for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates due to the production of metallo-β-lactamase (MBL). The ceftazidime-avibactam (CZA)/ aztreonam (ATM) combination represents a new therapeutic approach in MBL-positive isolates. Our study aims to determine distribution of carbapenemase genes in CRKP isolates and to investigate the in vitro synergistic effect of the CZA/ATM combination.Our study included 48 CRKP strains isolated from various clinical samples. Identification was performed using MALDI-TOF MS (bioMérieux, France

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Chen, Te-Li, Yi-Tzu Lee, Shu-Chen Kuo, et al. "Emergence and Distribution of Plasmids Bearing the blaOXA-51-Like Gene with an Upstream ISAba1 in Carbapenem-Resistant Acinetobacter baumannii Isolates in Taiwan." Antimicrobial Agents and Chemotherapy 54, no. 11 (2010): 4575–81. http://dx.doi.org/10.1128/aac.00764-10.

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ABSTRACT The bla OXA-51-like gene with an upstream ISAba1 (ISAba1-bla OXA-51-like gene) was originally found on the chromosomes of carbapenem-resistant or -susceptible Acinetobacter baumannii isolates. However, a plasmid-borne ISAba1-bla OXA-51-like gene has recently been identified in Acinetobacter genomic species 13TU and several A. baumannii isolates in Taiwan, and all of the isolates are carbapenem resistant. This study aimed to characterize the plasmids bearing the ISAba1-bla OXA-51-like gene and their significance in A. baumannii. Among the 117 ISAba1-bla OXA-51-like-harboring isolates c

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Avgoulea, Kalliope, Vincenzo Di Pilato, Olympia Zarkotou, et al. "Characterization of Extensively Drug-Resistant or Pandrug-Resistant Sequence Type 147 and 101 OXA-48-Producing Klebsiella pneumoniae Causing Bloodstream Infections in Patients in an Intensive Care Unit." Antimicrobial Agents and Chemotherapy 62, no. 7 (2018): e02457-17. http://dx.doi.org/10.1128/aac.02457-17.

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ABSTRACT Carbapenem-resistant Klebsiella pneumoniae causes important health care-associated infections worldwide. An outbreak of sequence type 11 (ST11) OXA-48-producing K. pneumoniae (OXA-48-Kp) isolates occurred in Tzaneio Hospital in 2012 and was contained until 2014, when OXA-48-Kp reemerged. The present study involved 19 bloodstream infection (BSI) OXA-48-Kp isolates recovered from 19 intensive care unit (ICU) patients hospitalized between August 2014 and July 2016. MICs were determined by broth microdilution. Beta-lactamase genes were detected by PCR. All isolates were typed by pulsed-fi

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Masyagutova, L. M., L. G. Gizatullina та R. X. Kudakaeva. "The prevalence of antibiotic resistance genes of carbopenemases of the metallo-β-lactamase group in enterobacteria strains isolated from patients of a multidisciplinary hospital in a region with a developed petrochemical industry". Sanitarnyj vrač (Sanitary Doctor), № 2 (29 січня 2024): 105–12. http://dx.doi.org/10.33920/med-08-2402-02.

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The research work included strains of Klebsiella pneumonaie (n = 128) isolated from patients of a multidisciplinary hospital in a large industrial city. The antibiotic sensitivity of the isolated pure cultures was studied in relation to the most popular antibacterial drugs in clinical practice (in the amount of 21), by the standard disco-diffusion method. Identification of resistance genes was carried out by PCR using commercial reagent kits «AmpliSens MDR-MBL-FL», «AmpliSens MDR-KPC/OXA-48‑FL». The results of determining the sensitivity of isolates isolated from the lower respiratory tract re

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Novikova, I. E., Z. Z. Sadeeva, R. A. Shakirzyanova, et al. "The using of the polymerase chain reaction for the detection of resistance genes in gram-negative bacteria in routine practice in a pediatric hospital." Russian Clinical Laboratory Diagnostics 67, no. 3 (2022): 180–85. http://dx.doi.org/10.51620/0869-2084-2022-67-3-180-185.

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Objective - assessment of RT-PCR for the detection of carbapenem-resistance genes in gram-negative bacteria. A total, 499 strains of gram-negative microorganisms isolated in two pediatric hospitals in 2019-2020 were studied. Species identification was performed using MALDI-ToF mass-spectrometry (Bruker Daltonics, Germany). Meropenem and imipenem minimal inhibitory concentration (MIC) was determined by E-test method (BioMerieux, France). The presence of acquired carbapenemase genes of IMP, NDM, VIM, KPC, OXA-48, OXA-23, OXA-40, OXA-58-groups was determined by RT-PCR. Klebsiella pneumoniae (34%)

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Petrova, Atanaska P., Irina D. Stanimirova, Ivan N. Ivanov, et al. "Carbapenemase Production of Clinical Isolates Acinetobacter baumannii and Pseudomonas aeruginosa from a Bulgarian University Hospital." Folia Medica 59, no. 4 (2017): 413–22. http://dx.doi.org/10.1515/folmed-2017-0060.

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AbstractBackground: Production of Bla OXA-23, OXA-24, OXA-58 and hyperexpression of OXA-51 due to ISAba1 insertion sequence are the leading causes of carbapenem resistance in Acinetobacter baumannii. The loss of OprD transmembrane protein and the overexpression of some effl ux pumps are considered to be the main factors for carbapenem resistance in Pseudomonas aeruginosa whereas metallo-enzymes’ production has a secondary role. Aim: Тo examine the carbapenem resistance due to carbapenemase production among clinically signifi cant Gram-negative non-fermenters from St George University hospital,

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Su, Harun Reşid, Özge Turhan, Cemile Aylin Erman Daloğlu, et al. "Molecular Epidemiology of Carbapenem-Resistant Enterobacterales Strains Isolated from Blood Cultures in Antalya, Turkey." Laboratory Medicine 51, no. 6 (2020): 601–5. http://dx.doi.org/10.1093/labmed/lmaa017.

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Abstract Objective The aim of this study was to investigate the prevalence of carbapenemase and CTX-M genes among 330 blood culture isolates of Enterobacterales with reduced susceptibility to at least 1 carbapenem, between 2010 and 2015. Methods BD Max CRE assay and in-house PCR were used to detect carbapenemase and CTX-M genes. Results At least 1 carbapenemase gene was detected among 113 (74.3%) of the 152 carbapenem resistant isolates. The OXA-48 (69.7%) was the most common carbapenemase followed by VIM, NDM and IMP, whereas no tested isolates were KPC-positive. Eighty-six isolates (56.6%) h

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He, Chao, Yi Xie, Lei Zhang, et al. "Increasing imipenem resistance and dissemination of the ISAba1-associated bla OXA-23 gene among Acinetobacter baumannii isolates in an intensive care unit." Journal of Medical Microbiology 60, no. 3 (2011): 337–41. http://dx.doi.org/10.1099/jmm.0.022681-0.

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The antibiotic susceptibility of Acinetobacter calcoaceticus–Acinetobacter baumannii complex strains recovered from the intensive care unit (ICU) of West China Hospital, Sichuan, PR China, from 2006 to 2009 was investigated. The identification of A. baumannii and analysis of carbapenemase-encoding genes and their relationship with ISAba1 were performed by PCR. Furthermore, a DiversiLab repetitive extragenic palindromic sequence-based PCR (rep-PCR) microbial typing system and a multilocus sequence typing (MLST) scheme were applied to assess the genetic relationship of the isolates. The results

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Toleman, Mark A., Kenneth Rolston, Ronald N. Jones та Timothy R. Walsh. "Molecular and Biochemical Characterization of OXA-45, an Extended-Spectrum Class 2d′ β-Lactamase in Pseudomonas aeruginosa". Antimicrobial Agents and Chemotherapy 47, № 9 (2003): 2859–63. http://dx.doi.org/10.1128/aac.47.9.2859-2863.2003.

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ABSTRACT As part of the CANCER Antimicrobial Surveillance Program in North America, a clinical strain of Pseudomonas aeruginosa, strain 07-406, isolated in Texas was found to be resistant to all antimicrobials except polymyxin B. Genetic analysis of this isolate identified two unique extended-spectrum β-lactamase genes. One, bla VIM-7, encoded a metallo-β-lactamase (unpublished data), and the other, bla OXA-45, described here, encoded a class D extended-spectrum β-lactamase. bla OXA-45 was isolated on a Sau3A1 genomic fragment of 1.8 kb and encodes a protein of 264 amino acids with the highest

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Odumosu, Bamidele T., Bola A. Adeniyi, and Ram Chandra. "First Detection of OXA-10 Extended-Spectrum Beta-Lactamases and the Occurrence of mexR and nfxB in Clinical Isolates of Pseudomonas aeruginosa from Nigeria." Chemotherapy 61, no. 2 (2015): 87–92. http://dx.doi.org/10.1159/000441712.

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Background: The characterization of β-lactamase production in Pseudomonasaeruginosa is rarely reported in Nigeria. The objective of this study was to investigate the occurrence and characterize the different β-lactamases as well as mechanisms of fluoroquinolones resistance among P. aeruginosa isolated from various clinical sources from Nigeria. Materials and Method: Isolates were investigated using PCR, RFLP and sequencing for the detection of various β-lactamases and efflux pump regulator genes. Result: The prevalence of OXA-10, AmpC, CTX-M and SHV in P. aeruginosa was 80, 70, 5 and 5%, respe

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Hatrongjit, Rujirat, Peechanika Chopjitt, Parichart Boueroy, and Anusak Kerdsin. "Multiplex PCR Detection of Common Carbapenemase Genes and Identification of Clinically Relevant Escherichia coli and Klebsiella pneumoniae Complex." Antibiotics 12, no. 1 (2022): 76. http://dx.doi.org/10.3390/antibiotics12010076.

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Carbapenem-resistant Enterobacterales (CRE) species are top priority pathogens according to the World Health Organization. Rapid detection is necessary and useful for their surveillance and control globally. This study developed a multiplex polymerase chain reaction (mPCR) detection of the common carbapenemase genes NDM, KPC, and OXA-48-like, together with identification of Escherichia coli, and distinguished a Klebsiella pneumoniae complex to be K. pneumoniae, K. quasipneumoniae, and K. variicola. Of 840 target Enterobacterales species, 190 E. coli, 598 K. pneumoniae, 28 K. quasipneumoniae, a

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Khan, Mubashir Ahmad, Amr M. Mohamed, Aftab Faiz, and Jawwad Ahmad. "Enterobacterial infection in Saudi Arabia: First record of Klebsiella pneumoniae with triple carbapenemase genes resistance." Journal of Infection in Developing Countries 13, no. 04 (2019): 334–41. http://dx.doi.org/10.3855/jidc.11056.

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Introduction: Carbapenemase producing Enterobacteriaceae are emerging as important pathogens worldwide with serious effects on patients’ outcome. The study aimed to investigate the emergence of carbapenemases associated with enterobacterial infection in Western region of Saudi Arabia. Methodology: Clinical isolates from suspected patients with enterobacterial infection were investigated over a one-year period from four tertiary care hospitals of Makkah, Saudi Arabia. All isolates were identified using Vitek-2 system and then screened for potential carbapenemase production using disk diff

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Hemarajata, Peera, Shangxin Yang, Janet A. Hindler та Romney M. Humphries. "Development of a Novel Real-Time PCR Assay with High-Resolution Melt Analysis To Detect and Differentiate OXA-48-Like β-Lactamases in Carbapenem-Resistant Enterobacteriaceae". Antimicrobial Agents and Chemotherapy 59, № 9 (2015): 5574–80. http://dx.doi.org/10.1128/aac.00425-15.

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ABSTRACTThe rapid global spread of carbapenem-resistantEnterobacteriaceae(CRE) poses an urgent threat to public health. More than 250 class D β-lactamases (OXAs) have been described in recent years, with variations in hydrolytic activity for β-lactams. The plasmid-borne OXA-48 β-lactamase and its variants are identified only sporadically in the United States but are common in Europe. Recognition of these OXA-48-like carbapenemases is vital in order to control their dissemination. We developed a real-time PCR assay based on high-resolution melt analysis, usingblaOXA-48-like-specific primers cou

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Datta, Amitesh, Nageswari Gandham, Chanda R. Vyawahare, Shahzad Mirza, Savita Bhatia, and Prajakta B. Shinde. "Genetic Diversity of Carbapenemases-producing Acinetobacter baumannii Isolates at a Tertiary Teaching Hospital in Western India." International Journal of Applied & Basic Medical Research 15, no. 2 (2025): 91–97. https://doi.org/10.4103/ijabmr.ijabmr_498_24.

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Abstract Background: Acinetobacter baumannii is an alarming pathogen in hospital-acquired infections, particularly in the intensive care units (ICUs). Carbapenemases production and biofilm formation contribute significantly to the pathogenicity of the organism. Carbapenem resistance in A. baumannii is primarily due to the production of carbapenemases. Aim: The study was conducted to detect the presence of carbapenemase-encoding genes in A. baumannii along with their ability to form biofilm. In addition, this study also investigated the association between biofilm formation and carbapenemase ge

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Poirel, Laurent, Mariana Castanheira, Amélie Carrër та ін. "OXA-163, an OXA-48-Related Class D β-Lactamase with Extended Activity Toward Expanded-Spectrum Cephalosporins". Antimicrobial Agents and Chemotherapy 55, № 6 (2011): 2546–51. http://dx.doi.org/10.1128/aac.00022-11.

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ABSTRACTTwoblaOXA-48-like-positive isolates (Klebsiella pneumoniaeandEnterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance inEnterobacteriaceae. In both cases, sequencing identified β-lactamase OXA-163, differing from OXA-48 by a single amino substitution and a 4-amino-acid deletion. OXA-163 hydrolyzed penicillins, ceftazidime, and cefotaxime, whereas OXA-48 did not. However, OXA-163 had a much lower ability to hydrolyze carbapenems than OXA-48, therefore barely being considered a carbapenemase. In both isolates, theblaOXA-163

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Périchon, Bruno, Sylvie Goussard, Violaine Walewski та ін. "Identification of 50 Class D β-Lactamases and 65 Acinetobacter-Derived Cephalosporinases in Acinetobacter spp." Antimicrobial Agents and Chemotherapy 58, № 2 (2013): 936–49. http://dx.doi.org/10.1128/aac.01261-13.

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ABSTRACTWhole-genome sequencing of a collection of 103Acinetobacterstrains belonging to 22 validly named species and another 16 putative species allowed detection of genes for 50 new class D β-lactamases and 65 newAcinetobacter-derived cephalosporinases (ADC). All oxacillinases (OXA) contained the three typical motifs of class D β-lactamases, STFK, (F/Y)GN, and K(S/T)G. The phylogenetic tree drawn from the OXA sequences led to an increase in the number of OXA groups from 7 to 18. The topologies of the OXA and RpoB phylogenetic trees were similar, supporting the ancient acquisition ofblaOXAgene

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Demir, Hatice Kubra, and Yasar Nakipoglu. "Investigation of the prevalence of carbapenem resistance genes in faecal carriage of carbapenem resistant Klebsiella spp. isolates by multiplex real-time PCR method." Journal of Infection in Developing Countries 17, no. 11 (2023): 1606–12. http://dx.doi.org/10.3855/jidc.17892.

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Introduction: Increased carbapenem resistance in Klebsiella spp. strains causes high morbidity and mortality. The genes encoded for carbapenemaseare transferrable between different bacterial species. In the present study, we aimed to investigate carbapenem resistance genes in Klebsiella spp. strains. Methodology: Fifty Klebsiella spp. strains were isolated from rectal swabs of patients hospitalized in the neonatal intensive care unit (NICU). All strains were identified with API20E. The minimum inhibitory concentrations (MICs) of carbapenems were determined by the broth dilution method. The maj

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