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1

Gray, Kathryn Margaret. "Regulation of oxidative stress responses of rhizobium leguminosarum." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408404.

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2

Willey, Tara Louise. "Virulence and oxidative stress responses in Bacillus cereus." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615248.

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3

Titmus, Craig Edward. "Cell cycle and growth responses to oxidative stress in Arabidopsis." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608546.

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4

Erturk, Hatice Neval. "Responses of Superoxide Dismutases to Oxidative Stress in Arabidopsis thaliana." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/26061.

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Superoxide dismutases (SODs) catalyze the dismutation of superoxide radicals to oxygen and hydrogen peroxide. Mn SOD is localized in mitochondria, Cu-Zn SOD is in the cytosol and chloroplast, and Fe SOD is in chloroplasts. The effects of a chloroplast-localized oxidative stress, caused by methyl viologen or 3-(3, 4-dichlorphenyl)-1-1â dimethylurea (DCMU) on SOD populations were investigated. A cloned Arabidopsis thaliana Fe SOD gene was expressed in Escherichia coli and was purified from transformed cells. This protein was used to raise antibodies against A. thaliana Fe SOD which in turn
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5

Costa, Vítor Manuel Vieira da. "Oxidative stress in Saccharomyces cerevisiae : Molecular mechanisms of ethanol and hydrogen peroxide stress responses." Doctoral thesis, Universidade do Porto. Reitoria, 1998. http://hdl.handle.net/10216/9923.

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Dissertação de Doutoramento em Ciências Biomédicas, área de especialização em Bioquímica, apresentada ao Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto<br>O etanol, um dos principais produtos da fermentação de leveduras, é, acima de uma concentração crítica, tóxico para estas células, afectando o seu crescimento, viabilidade e taxa de fermentação. A caracterização dos mecanismos moleculares envolvidos na aquisição de tolerância ao etanol assume, portanto, uma grande importância biotecnológica. A correlação encontrada entre a indução da actividade da superóxido dismut
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Costa, Vítor Manuel Vieira da. "Oxidative stress in Saccharomyces cerevisiae : Molecular mechanisms of ethanol and hydrogen peroxide stress responses." Tese, Universidade do Porto. Reitoria, 1998. http://hdl.handle.net/10216/9923.

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Dissertação de Doutoramento em Ciências Biomédicas, área de especialização em Bioquímica, apresentada ao Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto<br>O etanol, um dos principais produtos da fermentação de leveduras, é, acima de uma concentração crítica, tóxico para estas células, afectando o seu crescimento, viabilidade e taxa de fermentação. A caracterização dos mecanismos moleculares envolvidos na aquisição de tolerância ao etanol assume, portanto, uma grande importância biotecnológica. A correlação encontrada entre a indução da actividade da superóxido dismut
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7

Goh, Ying Shyen. "Transcriptional regulators of oxidative stress responses in the nematode Caenorhabditis elegans." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61101.

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Reactive oxygen species are chemically reactive molecules that are crucial for many cellular functions, but their buildup can cause toxic damage, otherwise known as oxidative stress. Oxidative stress is thought to cause or exacerbate many diseases. To defend themselves against oxidative stress, cells mount sophisticated defenses to remove ROS and repair damage caused by ROS. In particular, sequence-specific DNA binding transcription factors induce the expression of cytoprotective enzymes upon stress. In the model organism Caenorhabditis elegans, the transcription factor SKN-1 is considered a “
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8

Marshall, Karyn Ann. "Bcl-2 and its involvement in neuronal responses to oxidative stress." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368085.

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9

Susanti, Dwi. "Sulfite reductase and thioredoxin in oxidative stress responses of methanogenic archaea." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/51423.

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Methanogens are a group of microorganisms that utilize simple compounds such as H2 + CO2, acetate and methanol for the production of methane, an end-product of their metabolism.  These obligate anaerobes belonging to the archaeal domain inhabit diverse anoxic environments such as rice paddy fields, human guts, rumen of ruminants, and hydrothermal vents.  In these habitats, methanogens are often exposed to O2 and previous studies have shown that many methanogens are able to tolerate O2 exposure.  Hence, methanogens must have developed survival strategies to be able to live under oxidative stres
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10

Ferreira, Thalita Montoril. "Biochemical and physiological responses of sorghum plants submitted to salt stress." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=17086.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>The plants are frequently exposed to environmental stresses, which cause imbalances in physiological and biochemical metabolism. This work aimed to study the physiological and biochemical changes of plant forage sorghum (Sorghum bicolor) genotype CSF18, depending on the time of salt stress. The seeds were sown in vermiculite moistened with distilled water, in a greenhouse conditions, and after seven days, the seedlings were transferred to trays with Hoagland solution diluted 1:2. After seven days, treatment was established stress s
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11

Chandrabalan, Kapiraj. "A microfluidic approach to the study of cellular responses to oxidative stress." Thesis, University of Hull, 2015. http://hydra.hull.ac.uk/resources/hull:12524.

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12

Boopathy, Archana Vidya. "Engineering stem cell responses using oxidative stress and notch ligand containing hydrogels." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51837.

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Heart failure is the leading cause of death worldwide. In 2013, the American Heart Association estimated that one American will die of cardiovascular disease every 39 seconds. While heart transplantation is the most viable treatment option, the limited availability of donor hearts has necessitated the search for treatment alternatives such as the use of adult stem cells for cardiac repair and regeneration. Following myocardial infarction (MI), the inflammatory cardiac microenvironment, limited survival of stem/progenitor cells, myocardial scarring and fibrosis affect cardiac regeneration. Thi
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Alcantara, Berenice Kussumoto de. "Experimental approaches to study the responses to Al stress in cultivated crops." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/11/11151/tde-10062014-105216/.

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This thesis was performed in the scope of International Graduation Program in which Universidade de São Paulo and The Ohio State University are inserted. In the first year of Ph.D. work we aimed to understand the effect of aluminum (Al) in root growth of Eucalyptus spp. and the relationship with biochemical parameters and transcriptional responses since there is little information about these responses for tree species. Aluminum is found naturally in the Earth crust, but under acidic conditions Al3+ ion becomes available and toxic to the plants. United States and Brazil possess large areas wit
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14

Davison, Glen. "Antioxidant supplementation and immunoendocrine responses to prolonged exercise." Thesis, Loughborough University, 2006. https://dspace.lboro.ac.uk/2134/12332.

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The depression of immune cell function that is typically observed after prolonged exercise is thought to be largely mediated by increased plasma concentrations of stress hormones and cytokines and possibly oxidative stress. The aims of this thesis were to determine the effects of acute and longer term oral antioxidant supplementation on immunoendocrine responses following prolonged exercise. In study 1 (Chapter 3) it was shown that vitamin C ingested acutely before and during prolonged exercise has little or no effect on immunoendocrine responses. Furthermore, the combined ingestion of vitamin
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15

Handley, Rebecca Anne. "Oxidative stress responses in Campylobacter jejuni : the role of the Peroxide Regulator PerR." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/48754/.

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Campylobacter jejuni is a microaerophilic foodborne pathogen capable of surviving the stressful, oxygen-exposed route from an avian host and entering into the human food chain. The ability of Campylobacter to survive oxidative stress is thought to contribute to the annual ~500,000 UK cases of campylobacteriosis. One of the main regulatory proteins involved in the protective response of C. jejuni to oxidative stress is the regulatory protein PerR, which regulates gene expression in a metal-dependent manner, controlling the transcription of a set of peroxidases. In this study the perR gene was i
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Li, Shengchun. "Antioxidant systems and protein phosphatases in metabolic and signaling responses to oxidative stress." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112086.

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Le stress oxydant est un acteur clé dans les réponses des plantes à des conditions contraignantes. En raison de la complexité de la régulation de l’état redox cellulaire, il reste beaucoup à élucider concernant les interactions entre différentes composantes dans ces conditions. Grâce à une approche de génétique inverse basée sur un mutant d’Arabidopsis déficient en catalase (cat2) qui présente des modifications d’état redox prévisibles et bien définies, cette étude a exploré les interactions entre le stress oxydant et (1) un gène spécifique impliqué dans la déphosphorylation des protéines, (2)
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Pereira, Ricardo Jorge Silva. "Mercury contamination and oxidative stress responses in the eye of wild fish (Liza aurata)." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14024.

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Mestrado em Toxicologia e Ecotoxicologia<br>Every animal uses the eyes to monitor the surrounding environment and maintain homeostasis. Mercury (Hg) (including methylmercury - MeHg) is a pernicious and ubiquitous contaminant in natural waters but the assessment of its potential to interfere with fish eyes is an almost unexplored issue. This thesis will contribute to fill this knowledge gap by the evaluation of mercury accumulation in grey mullet eye wall (Liza aurata) together with the assessment of biochemical endpoints related with the oxidative stress status. This approach was comple
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18

Furuhagen, Sara. "Application and interpretation of biomarkers in ecotoxicology - from molecular to individual level responses." Doctoral thesis, Stockholms universitet, Institutionen för miljövetenskap och analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-120161.

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The use of biomarkers is considered a promising alternative, or complement, to traditional ecotoxicological assays. Toxic effects are often initially manifested at the molecular or biochemical level, biomarkers are therefore used as sensitive indicators of toxic exposure. Ideally, biomarkers would also indicate reduced fitness and possible later effects at the individual or population levels. However, implementing biomarkers in ecotoxicology is challenging and few biomarkers have an established connection to reduced individual fitness. The aim of this thesis was to increase the value and impro
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Hoar, Dominic Nelson. "Towards an understanding of the regulation of the oxidative stress responses of Mycobacterium tuberculosis." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444421/.

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Knowledge of the mechanisms by which Mycobacterium tuberculosis regulates its defence against oxidative stress will aid in the development of drugs and vaccines to combat the extensive morbidity and mortality caused by tuberculosis. In this thesis I have investigated the SenX3-RegX3 two component signal transduction system, one of 12 such systems in M. tuberculosis , which is essential for virulence in a mouse model and is similar to systems in other organisms that are involved in sensing oxygen. By complementing the attenuated growth of the senX3 and regX3 null mutants in mice I have shown th
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Loughland, Isabella. "Transient responses to thermal change and underlying mechanisms." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27954.

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Fluctuations in the thermal environment are ubiquitous and occur at different time scales. Organisms can respond via physiological adjustments that compensate for the negative effects of temperature change, and these responses also occur at various temporal scales. Understanding the proximal mechanisms that permit plastic responses is key to determining the timescales and contexts in which they may be adaptive. Here, I investigated the physiological responses and mechanisms by which organisms cope with thermal variation, ranging from rapid responses to short-term warming, to longer-term temper
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Turbyville, Thomas Jefferson. "Using Phylogenetically Conserved Stress Responses to Discover Natural Products with Anticancer Activity." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1078%5F1%5Fm.pdf&type=application/pdf.

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22

Arnolds, Judith Lize. "Oxidative stress responses in the aquatic macrophyte, Ceratophyllum Demersum L., as biomarkers of metal exposure." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2649.

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Thesis (DTech (Environmental Health))--Cape Peninsula University of Technology, 2017.<br>Metal pollution in aquatic environments is considered a major environmental concern because of variation in several abiotic factors that impose severe restrictions on organisms living in these areas. Ceratophyllum demersum L. (family Ceratophyllaceae), a hornwort or coontail, free floating rootless macrophyte has been suggested a suitable model for investigating metal stress and was used in the current study. This study assessed the use of selected biological responses, namely antioxidant responses and cha
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Feairheller, Deborah Lynn. "Race-Dependent Modulation of Endothelial Cell Responses to Shear Stress: Implications for Vascular Health in African Americans." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/121935.

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Kinesiology<br>Ph.D.<br>It is known that African American ethnicity is an independent risk factor for exaggerated oxidative stress which is intricately intertwined with inflammation, hypertension (HT), and cardiovascular disease (CVD). The purpose of this dissertation study was to examine the racial differences that exist between African Americans and Caucasians in oxidative stress levels at the molecular level using an in vitro model of Human Umbilical Vein Endothelial Cells (HUVECs). African American HUVECs were found to have significantly higher baseline levels of oxidative stress in vitro
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Wu, Haoxiang. "Responses of indoor moulds to water dynamics : the transient water conditions rendered by non-24 h air-conditioning." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/798.

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Due to rapid urbanisation, people in metropolises spend the majority of their time indoors. Indoor mould contamination, as one of the most pungent biohazards in built environments, can ubiquitously present in humid areas and potentially compromise the health of occupants. Governmental institutions like the World Health Organisation and United States Environmental Protection Agency have put forward guidelines for indoor mould prevention. However, these guidelines normally require occupants to maintain a low indoor humidity (<75% or even 40%), and thus, in tropical and subtropical areas, one of
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Leitao, Beatriz Belchior. "The role of the SUMO pathway in the cellular responses to oxidative stress signals in human endometrium." Thesis, Imperial College London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544293.

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Achan, Beatrice. "The role of Candida albicans oxidative stress responses in triggering filament formation and macrophage escape following phagocytosis." Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/4176.

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Candida albicans is an important opportunistic fungal pathogen which causes life threatening systemic diseases in immunocompromised people. An important virulence attribute of C. albicans is morphological plasticity. Yeasts engulfed by macrophages can transition to a hyphal filamentous morphology which either induce pyroptosis or rupture the phagosomal membrane of the macrophage and evade the toxic reactive oxygen species (ROS) generated by the NADPH oxidase complex of the phagocyte. Recent studies revealed that ROS causes cell cycle arrest resulting in hyperpolarised bud formation in C. albic
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McGovern, Rose Laura. "The role of reactive oxygen species and oxidative stress in the genomic and metabolic responses to exercise." Thesis, Ulster University, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.686439.

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Exercise is associated with a plethora of transcriptional responses preceding metabolic and cardiovascular adaptations, often attributed to ROS. The relationship between ROS and the metabolic and genomic response to exercise has not been fully defined. This thesis explored ROS generation following moderate aerobic exercise in combination with either antioxidant (lycopene) supplementation (to limit ROS formation) or hypoxia (to induce a reductive, rather than oxidative stress) in healthy males. Measures of ROS production and oxidative stress (EPR spectroscopy, LOOH, isoprostanes, SOD, LSA) and
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Chilton, Hayley C. "The Role of Sirtuin Inhibitors on the Proteomic Responses of the Mussels Mytilus galloprovincialis and Mytilus trossulus to Menadione Induced Oxidative Stress." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1379.

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Global climate change imposes physiological constraints on marine ecosystems that can alter the distribution of intertidal organisms. In one such instance, the native cold-adapted mussel Mytilus trossulus is being replaced along its southern range by the invasive warm-adapted Mytilus galloprovincialis. These blue mussels occur throughout rocky intertidal zones where they are subjected to greatly varying environmental conditions known to induce oxidative stress. We hypothesize that while under acute stress, related Mytilus congeners undergo a shift in redox potential from NADH-fueled respirator
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Shen, Hua. "Responses Of paraoxonase 1 to dioxin-like pcb 126 ( 3,3',4,4',5-pentachlorobiphenyl): mechanisms and consequences." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2770.

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Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants that have been associated with various adverse health effects in humans and wildlife. Dioxin-like PCBs elicit a broad spectrum of biochemical and toxic changes including cardiovascular disorders. Paraoxonase 1 (PON1), an antioxidant enzyme, prevents oxidative stress and plays key roles in the pathogenesis of atherosclerosis. The overall goal of this dissertation is to investigate the mechanism and role of PON1 in the antioxidant defense to the exposure of 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB 126), the most potent cong
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Purdom-Dickinson, Sally Elizabeth. "Early Responses to Oxidative Stress In Heart Cells: Signals From The Cell Membrane To The Nucleus and Beyond." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1310%5F1%5Fm.pdf&type=application/pdf.

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Osório, João Vasco de Carvalho. "Mucosal and physiological responses of Atlantic salmon (Salmo salar) in brackish water RAS following peracetic acid-based disinfection." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2020. http://hdl.handle.net/10400.5/20695.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Peracetic acid (PAA), a strong oxidative disinfectant, is effective against several microorganisms at low concentrations, requires short contact time and degrades rapidly into innocuous residues, thus considered a promising option for routine disinfection in aquaculture production. However, comprehensive knowledge of the impacts of the oxidant PAA on fish health is required for its safe application. This study documented the physiological impacts of periodic PAA exposure in Atlantic salmon (Salmo salar) post-smolts reared in brackis
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Verma, Narendra Kumar. "Ankrd2 modulates NF-kB mediated inflammatory responses during muscle differentiation." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423734.

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Adaptive responses of skeletal muscle regulate the nuclear shuttling of the sarcomeric protein Ankrd2 that can transduce different stimuli into specific adaptations by interacting with both structural and regulatory proteins. In a genome-wide expression study on Ankrd2 knockout or overexpressing primary proliferating or differentiating myoblasts, we found an inverse correlation between Ankrd2 levels and the expression of proinflammatory genes and identified Ankrd2 as a potent repressor of inflammatory responses through direct interaction with the NF-kB repressor subunit p50. In particular, we
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Flanagan, Marc David. "The roles and regulation of ubiquitin/ubiquitin-like protein conjugation pathways in responses to oxidative stress in Schizosaccharomyces pombe." Thesis, University of Newcastle Upon Tyne, 2013. http://hdl.handle.net/10443/1825.

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Ubiquitin and ubiquitin-like proteins (Ubls) are conjugated to proteins to regulate activity, stability, localisation or function. Ubiquitin/Ubl conjugation pathways are highly conserved in eukaryotes, and usually involve activating enzymes (E1s) and conjugating enzymes (E2s) specific for each ubiquitin/Ubl. Many studies have suggested that ubiquitin/Ubl conjugation pathways are important for oxidative stress resistance. However, there is much to learn regarding the roles of these pathways in oxidative stress responses. Additionally, limited studies in mammalian cells and yeast have indicated
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Bjur, Eva. "Virulence of Salmonella enterica serovar typhimurium and innate antibacterial host responses /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-946-7/.

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Rodrigo, Ana Patrícia Carreira. "Integration of sediment contamination with multi–biomarker responses in a novel bioindicator candidate (Sepia officinalis) for risk assessment in impacted estuaries." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8080.

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Dissertação para obtenção do Grau de Mestre em Engenharia do Ambiente<br>The Sado estuary (SW Portugal) is an example of the type of pressures coastal areas are subjected to, encompassing fisheries, agriculture, industries and other human activities, most of which may act as sources of aquatic pollution. In order to assess the impact of aquatic contaminants onto the biota, biomonitoring is compelling and the search for suitable bioindicator organisms is mandatory. The common cuttlefish, Sepia officinalis, is a very important species to fisheries, especially in the Sado estuary, albeit yet uns
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Keyster, Marshall. "Nitric oxide-mediated signaling in legumes and its role in maize responses to salt stress." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6565.

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Mahdi, A. K. "Molecular pathology : the roles of P53 in the oxidative stress and DNA damage responses in chronic liver disease and hepatocellular carcinoma." Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/4147.

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Non-alcoholic fatty liver disease (NAFLD) has become the commonest form of chronic liver disease in western nations and is rapidly rising in the Asia-Pacific. As yet treatments are limited to diet modification and life style change, which is rarely effective. NAFLD is associated with an increasing risk of developing hepatocellular carcinoma (HCC), which is also increasing markedly and is a significant cause of death. The disease progression is difficult to study in humans as invasive procedures are needed. We have developed a mouse model reflecting the human condition to investigate mechanisms
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Aigster, Annelisse. "Physicochemical and Sensory Properties of Resistant Starch-Based Cereal Products and Effects on Glycemic and Oxidative Stress Responses in Hispanic Women." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/28934.

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The incidence of type 2 diabetes is considered an epidemic in Western countries, and its prevalence is more common in the Hispanic population than in non-Hispanic whites. Postprandial hyperglycemia has been associated with oxidative stress (OS), thus; reducing postprandial glycemia and/or OS through dietary consumption of resistant starch (RS) may be one approach to help modulate glucose and insulin responses. The purpose of this study was twofold: 1) to evaluate the physicochemical and sensory properties of cereal food products supplemented with RS. 2) to compare the effects of a single inges
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Aljbour, Samir [Verfasser], Martin [Akademischer Betreuer] Zimmer, Martin [Gutachter] Zimmer, and Andreas [Gutachter] Kunzmann. "Metabolic and Oxidative Stress Responses of Cassiopea sp. to Environmental Stress : Towards a Better Physiological Understanding of Jellyfish's Tolerance / Samir Aljbour ; Gutachter: Martin Zimmer, Andreas Kunzmann ; Betreuer: Martin Zimmer." Bremen : Staats- und Universitätsbibliothek Bremen, 2017. http://d-nb.info/1150833904/34.

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Le, Thi Tuyet Cham [Verfasser], and Petra [Akademischer Betreuer] Bauer. "The Zn-finger transcription factor ZAT12 : a molecular link between iron deficinecy responses and oxidative stress / Thi Tuyet Cham Le. Betreuer: Petra Bauer." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1075190363/34.

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Munyemera, Ivan. "Combined Effects of Perfluorooctane sulfonic acid (PFOS) and Carbon dioxide (CO2) on oxidative stress responses in the gill of Atlantic cod (Gadus morhua)." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for bioteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25206.

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Increasing levels of anthropogenic CO2 in atmosphere and aquatic environment have been regarded as significant force behind global climate changes. The aquatic environment is also a heavy recipient for pollutants embedded in among others municipal and industrial wastewater. Despite this, very little effort has currently been put in investigating the potential toxic effects of aquatic pollutants on aquatic organisms (fish) in a continuously changing aquatic environment driven by global climate change. In the present study, juvenile Atlantic cod (gadus morhua) were exposed to Perfluorooctane sul
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Chaouch, Sejir. "Analysis of the role of H2O2 and intracellular oxidative stress in pathogen responses using a conditional catalase-deficient mutant and metabolite profiling approaches." Paris 11, 2010. http://www.theses.fr/2010PA112198.

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Les formes actives de l'oxygène (FAO) constituent un élément clé pour la réponse des plantes aux stimuli de l'environnement parmi lesquels l'attaque par des agents pathogènes pour laquelle le rôle des FAO est bien étudié. Cependant, l'origine subcellulaire de production des FAO ainsi que l'impact des FAO produites dans différents compartiments subcellulaires au cours de la réponse aux agents pathogènes restent à élucider. Il en est de même concernant l'existence d'éventuelles interactions entre FAO d'origines subcellulaires différentes. Les peroxisomes constituent une source majeure de H2O2 pr
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Wu, Pianpian. "Risks of Cadmium Nanoparticles on Estuarine Organisms : Ecotoxicological Effects of Engineered Cadmium Nanoparticles through Biochemical and Behavioral Responses in Two Marine Invertebrates, Nereis diversicolor and Scrobicularia plana." Thesis, Uppsala universitet, Limnologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179100.

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There is an increasing concern over the safety of engineered nanoparticles (ENPs) to humans and the environment. It is important that the environmental risks of these particles to be tested under research and regulatory schemes, e.g. Nano Risks to the environment &amp; Human Health (NanoReTox) under Seventh Framework Programme (FP7) in EU. Due to their unique properties and the fact that their detection and characterization in complex matrices is challenging, classic analytical methods and test approaches for assessing environmental risk may not be appropriate for ENPs. In this paper I present
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Kelly, Richard Thomas II. "Chemical Inhibition of Nitrification: Evaluating Methods to Detect and Characterize Inhibition and the Role of Selected Stress Responses Upon Exposure to Oxidative and Hydrophobic Toxins." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/28151.

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This research first examined nitrification inhibition caused by different classes of industrially relevant chemicals on activated sludge and found that conventional aerobic nitrification was inhibited by single pulse inputs of every chemical tested, with 1-chloro-2,4-dinitrobenzene (oxidant) having the most severe impact, followed by alkaline pH 11, cadmium (heavy metal), cyanide, octanol (hydrophobic) and 2,4-dinitrophenol (respiratory uncoupler). Of the different chemicals tested, the oxidative and hydrophobic chemicals showed severe nitrification inhibition relative to other treatment proc
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45

Martins, Nathan Dias. "Efeitos da microcistina-LR sobre parâmetros cardiorrespiratórios e biomarcadores do estresse oxidativo de duas espécies de teleósteos neotropicais, traíra, Hoplias malabaricus (Bloch, 1794) e matrinxã, Brycon amazonicus (Spix & Agassiz, 1829)." Universidade Federal de São Carlos, 2015. https://repositorio.ufscar.br/handle/ufscar/7211.

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Submitted by Izabel Franco (izabel-franco@ufscar.br) on 2016-09-15T14:54:18Z No. of bitstreams: 1 TeseNDM.pdf: 2605858 bytes, checksum: bff58bf7890c21ba2d47c2079816f268 (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-09-16T19:26:12Z (GMT) No. of bitstreams: 1 TeseNDM.pdf: 2605858 bytes, checksum: bff58bf7890c21ba2d47c2079816f268 (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-09-16T19:26:23Z (GMT) No. of bitstreams: 1 TeseNDM.pdf: 2605858 bytes, checksum: bff58bf7890c21ba2d47c2079816f268 (MD5)<br>Made available
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Calvo, Arnedo María Isabel 1983. "Study of the role of Pap1 as a sensor of H2O2 and as a transcriptional activator of stress responses in Schizosaccharimyces pombe." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/128679.

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En el laboratorio se utiliza como sistema modelo la levadura Schizosaccaromyces pombe para poder estudiar la respuesta a estrés oxidativo. Las dos rutas principales de respuesta a estrés oxidativo son las del factor de transcripción Pap1 y la de la MAP quinasa Sty1. Cuando aplicamos a la célula bajas dosis de H2O2, Pap1 que se encuentra en el citoplasma en estado reducido, sufre un cambio conformacional, se oxida, y activo viaja al núcleo, donde se une a diferentes promotores para activar su transcripción. La caracterización de Pap1 como sensor de H2O2 y como factor de transcripción centran
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Lorentzen, Kari. "Cellular Lipid Homeostasis and Oxidative Stress Responses in the Liver of Atlantic Cod (Gadus morhua) Exposed to a Quantifiable Measure of Climate Change (CO2) and Perfluorooctane Sulfonate (PFOS)." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for bioteknologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-21413.

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Increase in atmospheric carbon dioxide (CO2) is generally regarded as the main cause of global climate change, and this condition has also been shown in aquatic environments. In addition, emerging contaminants are ubiquitously distributed in the aquatic environment, and interactions between CO2 and emerging pollutants in biological systems are inevitable. The aim of this master thesis was to elucidate the combined effect of the environmental contaminant perfluorooctane sulfonate (PFOS) and increased water CO2 concentration on oxidative stress response and lipid homeostasis in liver of juvenile
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Leveque, Clément. "Etude des variations de pressions partielles d'oxygène sur les réactions cellulaires chez le sujet sain." Electronic Thesis or Diss., Brest, 2024. http://www.theses.fr/2024BRES0040.

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La compréhension de l'impact de l'oxygène sur les organismes révèle des réponses cellulaires complexes. Des études exposant des sujets sains pendant 1 heure à diverses pressions partielles d'oxygène révèlent des différences quantitatives et cinétiques significatives des réponses cellulaires. En hypoxie normobare, un pic de radicaux libres d’oxygène est observé 30 minutes après l’exposition, sans activation immédiate de réponses antioxydantes. L’interleukine-6 augmente progressivement, atteignant un pic à 8h, reflétant une inflammation évolutive. En hyperoxie normobare, la production de radicau
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Plant, Stuart D. "The response of human umbilical vein endothelial cells and blood platelets to modified NiTi surfaces." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275630.

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50

Andrade, Lara Filipe Rocha. "Hereditary hemochromatosis: cellular response to oxidative stress." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12495.

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Mestrado em Bioquímica - Bioquímica Clínica<br>Iron is a key element for basic cellular functions. If iron homeostasis is not maintained it may lead to iron overload. Patients with Hereditary Hemochromatosis (HH) and with the C282Y HFE mutation have a progressive severe iron overload that, if it is not treated, may lead to tissue damage, that mostly culminate in hepatic cirrhosis and carcinoma. Having in mind that tissue damage in HH may be related with oxidative stress (OS) caused by iron toxicity, it is important to understand in what way the OS defense is acting in cells from HH patients wi
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