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Dissertations / Theses on the topic 'Parkinsonian disease'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Erickson-Davis, Cordelia R. "Neurofeedback training for Parkinsonian tremor and bradykinesia /." Connect to online version, 2006. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2006/153.pdf.

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2

Laverty, Vivian D. "Parkinsonian Personality: Psychometric Description of Intellectual-Motor Functioning." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc332144/.

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In an attempt to determine the normative levels in health attribution and emotional, intellectual, and neuromuscular functioning in the parkinsonian population, 31 diagnosed parkinsonian volunteers recruited from exercise classes and/or organizations were tested. Health attribution was measured by the Health Attribution Test (HAT), personality factors by the Clinical Analysis Questionnaire (CAQ), general intellectual level by the Peabody Picture Vocabulary Test- Revised (PPVT-R) and the Intellectual Processes subscale of the Luria-Nebraska Neuropsychological Battery (Luria- Intelligence), and

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3

Kozlosky, Kenneth M. "Perception of Parkinsonian speech ratings by self and listeners vs. acoustic measures /." Bowling Green, Ohio : Bowling Green State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1237512058.

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4

Chu, Chi-yuen Andrew. "A study on mitochondrial uncoupling protein 4 (UCP4) in Parkinsonian models." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39634449.

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5

Chu, Chi-yuen Andrew, and 朱志遠. "A study on mitochondrial uncoupling protein 4 (UCP4) in Parkinsonian models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634449.

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6

Lucarelli, Marisa Nicole. "Acoustic and Articulatory Kinematic Vowel Space in Parkinsonian Speech." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1556877018282911.

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7

Kwok, Hon-hung Ken. "The role of UCP5 in mitochondrial dysfunction in Parkinsonian models." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508233.

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8

Manal, Kurt T. "Temporal assimilations during bi-manual movements in non-impaired and Parkinsonian individuals." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61329.

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When bi-lateral movements of differing difficulty are performed as rapidly as possible the "easier" of the two limbs slows down and is attracted to the temporal structure of the more difficult movement. Simultaneous movements are expected to be severely compromised in Parkinson's Disease (PD). The purpose of this study was to investigate whether Parkinsonians elicit temporal assimilations in the belief that an assimilatory response may facilitate simultaneous bi-lateral control in PD.<br>Temporal attractions were elicited by the non-impaired subjects during the bi-lateral task. The increased m

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9

Kwok, Hon-hung Ken, and 郭漢洪. "The role of UCP5 in mitochondrial dysfunction in Parkinsonian models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508233.

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10

Gravelin, Anna Christine. "Categorization of Silent Intervals in Parkinsonian Speech: A Study of Pause." Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1496839309918692.

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11

Vinciati, Federica. "Electrophysiological properties of striatal neurons in the dopamine-intact and Parkinsonian brain." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:e4e84e31-bc00-43b2-a930-dc7fa4143b1a.

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The striatum is the major input structure of the basal ganglia, and is composed of two major populations of spiny projection neurons (MSNs), which give rise to the socalled direct and indirect pathways, and several types of interneuron. Dopaminergic inputs to striatum are critical for its proper function. Indeed, loss of dopaminergic neurons in Parkinsonism leads to motor disturbances, grossly disturbs striatal activity, and is associated with the emergence of excessively-synchronized network oscillations at beta frequencies (15-30 Hz) throughout the basal ganglia. How the distinct structural,

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12

Safi, Khaled. "Human postural stability analysis : application to Parkinsonian subjects." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC1066/document.

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L’analyse de la stabilité posturale chez l’homme a fait l’objet, ces dernières années, d’un intérêt grandissant au sein de la communauté scientifique. Le système postural permet de maintenir la stabilité du corps humain en posture statique ou dynamique. Cette capacité à maintenir cette stabilité devient critique dans le cas des sujets Parkinsoniens. La maladie de Parkinson a en effet une forte incidence sur la stabilité posturale. Un moyen efficace pour évaluer l’équilibre postural consiste à analyser les déplacements dans le plan horizontal du centre de pression du corps humain en posture ort

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13

Soares, Carolina Favarin [UNESP]. "Desvio de obstáculo e dupla tarefa motora durante a simulação de travessia de rua de indivíduos com Doença de Parkinson." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/154042.

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Submitted by Carolina Favarin Soares (carolfavarin@gmail.com) on 2018-05-21T20:39:47Z No. of bitstreams: 1 carolina_favarin_soares_defesa_mestradoRC1.pdf: 2442261 bytes, checksum: 21d0aeb7750d84b057cb9517082d6140 (MD5)<br>Approved for entry into archive by Ana Paula Santulo Custódio de Medeiros null (asantulo@rc.unesp.br) on 2018-05-22T13:27:23Z (GMT) No. of bitstreams: 1 soares_cf_me_rcla.pdf: 2400648 bytes, checksum: 5b24db06fe320d1b36801d9b3a8db819 (MD5)<br>Made available in DSpace on 2018-05-22T13:27:23Z (GMT). No. of bitstreams: 1 soares_cf_me_rcla.pdf: 2400648 bytes, checksum: 5b24db

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14

Jurkowski, Anita J. "Investigations of executive function with neuropsychology and electrophysiology in young, aged and Parkinsonian adults /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3060109.

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15

Trepanier, Lisa Laura. "Neuropsychological consequences of pallidal lesions and subthalamic stimulation for the treatment of Parkinsonian patients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ59157.pdf.

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16

Chung, Ka Yin. "Glutamate transporters in the rat basal ganglia : localization and modulations in normal and parkinsonian rats." HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/711.

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17

Wright, Alesia M. "Serotonergic and dopaminergic systems as targets for exogenous neurotoxins causing a parkinsonian syndrome." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-05022009-040759/.

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18

Caslake, Robert. "The incidence and short-term outcome of Parkinson's disease and other Parkinsonian disorders in North-east Scotland : the PINE study." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165853.

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A community-based, prospective study of the incidence of parkinsonism using multiple, overlapping recruitment methods was undertaken. From a base population of 311,770, followed over 3 years, 628 people were assessed. 293 were diagnosed with parkinsonism, of whom 53.2% had a baseline diagnosis of Parkinson’s disease (PD). 190 age and sex matched controls were also recruited. This cohort was combined with one recruited during a pilot study (83 patients) for calculation of incidence figures and follow-up, which will continue long-term. Using this combined cohort, age and sex specific incidence r

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19

Fox, Diane Patricia. "Effects of collaboration on problem solving performance in healthy elderly couples and Parkinsonian-caregiver dyads." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ32708.pdf.

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20

Song, Juxian, and 宋聚先. "Protective effects of chrysotoxine on Parkinsonian neurotoxins induceddopaminergic neuronal cell death in SH-SY5Y cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47150129.

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21

Chen, Tong Kai. "Development of Schisantherin A and baicalein nano-formulations with improved oral bioavailability, brain uptake, and anti-Parkinsonian activity." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3690809.

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22

Delfani, Kioumars. "Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-258-2.

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23

Bai, Hong. "Synthetic and metabolic studies on 1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine, a neurotoxic analog of the Parkinsonian inducing agent MPTP." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-08042009-040225/.

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24

LONGO, FRANCESCO. "Altered motor phenotype and dopamine transmission associated with mutations of the parkinsonian gene LRRK2." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2389103.

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The leucine-rich repeat kinase 2 mutation (LRRK2) G2019S in the kinase-domain is the most common genetic cause of late-onset autosomal dominant Parkinson’s Disease (PD), occurring in >85% of patients carrying this LRRK2 mutation. LRRK2-related PD is clinically indistinguishable from the classic idiopathic form, being characterized by classic neuropathological hallmarks such as progressive degeneration of the substantia nigra pars compacta (SNpc) dopaminergic neurons, gliosis and α-synuclein and ubiquitine-positive intraneuronal cytoplasmic inclusions. The main goal of this thesis work was to

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25

Cooper, Stephanie A., and University of Lethbridge Faculty of Arts and Science. "Parkinsonian sensory integration for balance control : time based postural effects of alterations in sensory information." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005, 2005. http://hdl.handle.net/10133/245.

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Changes in postural stability following sensory manipulation were investigated among Parkinson's disease patients and healthy older adults. Sixteen Parkinson's disease patients (PD; mean age 68.2 + 2.7 years) and sixteen older adults (control; mean age 67.6 + 2.6 years) performed quiet standing trials that progressed through baseline, sensory manipulation, and reintegration. Postural control following visual deprivation was assessed following alternate removal and reinsertion of visual information. Postural recovery following sensory incongruence was assessed following the termination of visua

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26

Sonne, James H. "EFFECTS OF INTRANASALLY ADMINISTERED DNSP-11 ON THE CENTRAL DOPAMINE SYSTEM OF NORMAL AND PARKINSONIAN FISCHER 344 RATS." UKnowledge, 2013. http://uknowledge.uky.edu/neurobio_etds/5.

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Due to the blood-brain barrier, delivery of many drugs to the brain has required intracranial surgery which is prone to complication. Here we show that Dopamine Neuron Stimulating Peptide 11 (DNSP-11), following non-invasive intranasal administration, protects dopaminergic neurons from a lesion model of Parkinson’s disease in the rat. A significant and dose-dependent increase in an index of dopamine turnover (the ratio of DOPAC to dopamine) was observed in the striatum of normal young adult Fischer 344 rats by whole-tissue neurochemistry compared to vehicle administered controls. Among animals

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27

Thota, Anil K. "Biomechanical Assessment of Normal and Parkinsonian Gait in the Non-human Primate During Treadmill Locomotion." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1338821968.

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28

McCormack, Alison. "The non-human primate as a model of human parkinsonism /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-624-7/.

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29

So, Hon-fai, and 蘇漢暉. "Age-dependent effects of mitochondrial function in skin fibroblasts and skeletal muscle derived from a Parkinsonian LRRK2 R1441G knockinmouse model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B50162846.

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Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra of the brain. The pathogenesis and etiology of PD are unclear. Mitochondrial dysfunction occurs in PD, causing a decrease in complex I activity in postmortem brain, and exacerbating reactive oxygen species production and ATP deficiency contributing to neuronal cell death. Mutation of leucine-rich-repeat kinase 2 (LRRK2) gene is the most common genetic factor identified in both familial and sporadic PD cases. Several mutations in LRRK2 have be

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30

Fen, Chien Hsin. "Estudo genético da doença de Parkinson." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-01062007-115551/.

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A doença de Parkinson (DP) é a segunda doença neurodegenerativa mais comum com uma prevalência aproximada de 3% em pacientes com mais de 64 anos. A doença é esporádica, mas o parkinsonismo primário (PP) familiar, decorrente de defeitos genéticos específicos, tem sido encontrado em cerca de 10% dos casos diagnosticados como DP. Os objetivos deste trabalho são analisar o DNA de pacientes com PP acompanhados no ambulatório do Grupo de Estudo de Distúrbios do Movimento da Clínica Neurológica do Hospital das Clínicas da FMUSP que apresentam início precoce (< 40 anos) ou história familiar positiva c

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31

Delgado, Zabalza Lorena. "Electrophysiological characterization of neuronal diversity in the substantia nigra pars reticulata in control and parkinsonian mice." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0052.

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La substance noire réticulée (SNr) est la principale structure de sortie des ganglions de la base (BG), un réseau sous-cortical contrôlant l'élaboration des programmes moteurs ainsi que des fonctions d'apprentissage cognitives et associatives. L'identification de types de cellules distincts dans le BG a joué un rôle clé pour comprendre les propriétés et les fonctions de ce circuit. Des études récentes suggèrent que la SNr est composé de plusieurs types de cellules mais jusqu'à présent cette diversité neuronale n'a jamais été prise en compte concernant le fonctionnement normal et pathologique d

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32

Umemura, Atsushi. "Diagnostic Accuracy of Apparent Diffusion Coefficient and 123I-Metaiodobenzylguanidine for Differentiation of Multiple System Atrophy and Parkinson's Disease." Kyoto University, 2015. http://hdl.handle.net/2433/200316.

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33

Lins, Lívia Cristina Rodrigues Ferreira. "Efeito neuroprotetor do Carvacrol em dois modelos experimentais da Doença de Parkinson: evidências comportamentais e imunohistoquímicas." Universidade Federal de Sergipe, 2017. https://ri.ufs.br/handle/riufs/3648.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Parkinson’s disease (PD) is a neurodegenerative disease characterized by a progressive degeneration of dopaminergic neurons in the Substantia Nigra pars compact (SNpc) with consequent depletion of dopamine in the striatum, which gives rise to characteristic motor symptoms of PD. Although its etiology of is unknown, several studies have been suggested that oxidative stress and inflammation play a critical function in the physiopathology of PD and antioxidant and ani-inflammatory agents could be helpful to slown down the dopa

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34

Aravamuthan, Bhooma Rajagopalan. "Comparing the radiological anatomy, electrophysiology, and behavioral roles of the pedunculopontine and subthalamic nuclei in the normal and parkinsonian brain." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:9a735b39-c1fe-4d5f-b05f-3385f27e6e58.

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Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and DBS of the pedunculopontine nucleus (PPN) have been shown to be effective surgical therapies for Parkinson’s disease (PD). To better understand the PPN and STN as DBS targets for PD, this research compares the anatomy, electrophysiology, and motor control roles of these nuclei. PPN and STN connections were examined in vivo in human subjects and in the non-human primate using probabilistic diffusion tractography. Both the PPN and STN were connected with each other and with the motor cortex (M1) and basal ganglia. After studying t

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35

Khan, Suliman. "Studying the Prevalence and Genetic Contributions to Parkinsonism in Pakistan." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366434.

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The current study investigated the prevalence and genetics of Parkinsonism and Parkinson’s disease (PD) in the Pakistani population. The prevalence of PD in the Pakistani population is unknown. Similarly, there are no well documented studies on the copy number variation (CNV) or the prevalence of variants such as the G2019S mutation in the LRRK2 gene and the D620N mutation in the VPS35 gene. The Pakistani population is highly consanguineous, which may be advantageous for the identification of variants associated with recessive forms of Parkinsonism. In the present study, we estimated the prev

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36

Lamine-Ajili, Asma. "Les propriétés antiapoptotiques et antiautophagiques du Pituitary Adenylate Cyclase-Activating Polypeptide assurent une protection neuronale dans des modèles in vitro et in vivo de la maladie de Parkinson." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR048/document.

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La maladie de Parkinson (MP) est caractérisée par la dégénérescence des neurones dopaminergiques du mésencéphale. Elle est notamment causée par des évènements délétères tels le stress oxydatif et la neuro-inflammation, et ceux-ci mènent à la destruction des neurones par divers types de mort cellulaire. Dans ce contexte, le Pituitary Adenylate Cyclase-activating Polypeptide (PACAP), avec ses propriétés antiapoptotiques, anti-inflammatoires et antioxydantes et son aptitude à traverser la barrière hémoencéphalique (BHE), est capable d’exercer une puissante activité neuroprotectrice dans divers mo

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37

Fabbrica, Ilaria. "L’efficacia del trattamento Automated Mechanical Peripheral Stimulation sui parametri cinematici del cammino nei soggetti affetti da Morbo di Parkinson: revisione sistematica della letteratura." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24578/.

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Background.Il morbo di Parkinson è la seconda patologia neurodegenerativa nel mondo per prevalenza, con previsione di raddoppiamento dei numeri attuali, soprattutto nella popolazione tra i 45 e i 65 anni. Tra i segni e sintomi di questa patologia si è evidenziato un aumento della soglia di sensibilità nella pianta del piede, tale da contribuire al peggioramento delle problematiche motorie. L’AMPS ha la finalità di stimolare le zone più deficitarie della pianta del piede per migliorarne la sensibilità, influenzando positivamente la componente motoria, in particolare il cammino. Obiettivi.Val

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38

Quinn, Niall. "Young onset of Parkinson's disease and juvenile parkinsonism." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283845.

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39

Huber, Steven J. "State-dependent memory in Parkinson's disease /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266691093783.

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40

Khan, Naheed Lubna. "Familial parkinsonism (Parkinson's disease and early onset parkinsonism) : a genetic, clinical study and 18F-dopa PET study." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1444816/.

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This thesis reports a study of familial parkinsonism using diverse scientific tools of both molecular genetics and positron emission tomography functional imaging. Population-based allelic association studies are also described. Molecular and clinical characterisation of the largest British kindred with autosomal Parkinson's disease (PD). Genome wide linkage analysis was used to map the sub-chromosomal location of the disorder as the first step for disease-gene identification. The disease mapped to a 50cM region on the short arm of chromosome 12 overlapping a locus, PARK8 that had just been re

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41

Camillo, Maira. "Hesitações em deslizamentos do dizer de sujeitos parkinsonianos e não-parkinsonianos : um estudo comparativo /." São José do Rio Preto : [s.n.], 2011. http://hdl.handle.net/11449/86557.

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Orientador: Lourenço Chacon Jurado Filho<br>Banca: Rosana do Carmo Novaes Pinto<br>Banca: Larissa Cristina Berti<br>Resumo: A proposta deste estudo foi investigar em que medida se aproximam e/ou se distanciam os momentos de quebras na amarração dos significantes, mostrados por hesitações, na atividade discursiva de três sujeitos com Doença de Parkinson e de três sujeito sem lesão neurológica. Os objetivos que nortearam essa investigação foram: (a) comparar, nos dois grupos de sujeitos, as características de suas rupturas na cadeia significante; e (b) recuperar, em ambos os grupos, fatos de seu

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42

Camillo, Maira [UNESP]. "Hesitações em deslizamentos do dizer de sujeitos parkinsonianos e não-parkinsonianos: um estudo comparativo." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/86557.

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Made available in DSpace on 2014-06-11T19:22:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-11Bitstream added on 2014-06-13T18:48:53Z : No. of bitstreams: 1 camillo_m_me_sjrp.pdf: 593366 bytes, checksum: abcc6c445f86bb0d0dc22a08bbbb3a3e (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A proposta deste estudo foi investigar em que medida se aproximam e/ou se distanciam os momentos de quebras na amarração dos significantes, mostrados por hesitações, na atividade discursiva de três sujeitos com Doença de Parkinson e de três sujeito sem lesão neurológica. O

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43

Scatozza, Rossella. "Parkinson's disease and degenerative parkinsonism: relationship between clinical and neurobiological aspects." Doctoral thesis, Università di Catania, 2015. http://hdl.handle.net/10761/4045.

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Il neurovascula coupling indica il processo mediante il quale l unità neuro vascolare modula la complessa relazione tra attività neuronale, fattori emodinamici e segnali intracellulari. Recenti studi individuano la possibile associazione tra alterazioni dell emodinamica cerebrale e il decadimento della performance cognitiva,in parte riconducibile ad una compromissione del fisiologico signaling tra gli elementi dell unità neuro vascolare. Obiettivo dello studio è quello di indagare la possibile relazione tra disturbi cognitivi ed alterazioni della reattività cerebrovascolare in pazienti affetti

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44

Lui, Nga Ping. "Endogenous neuroprotective mechanisms in early stages of rat parkinsonism." HKBU Institutional Repository, 2011. http://repository.hkbu.edu.hk/etd_ra/1251.

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45

Cobbah, William G. K. "The computer assessment of handwriting and drawing movement dysfunction in Parkinsonism." Thesis, University of Kent, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.344105.

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46

Cardoso, Erika Sproesser. "Avaliação e analise sociometrica do Parkinsoniano no contexto familiar." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309064.

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Orientadores: Elisabete Abib Pedroso de Souza, Elizabeth Maria Aparecida Barasnevicius Quagliato<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-13T10:01:40Z (GMT). No. of bitstreams: 1 Cardoso_ErikaSproesser_D.pdf: 2355364 bytes, checksum: ade09cde99f6174c28c544830abd0634 (MD5) Previous issue date: 2009<br>Resumo: A doença de Parkinson (DP) é uma enfermidade crônica, progressiva, podendo ser controlada e não tem cura. É necessário avaliar não apenas o aspecto motor na DP, mas, também, os aspectos emocionais, compo

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47

Xie, Tao, and 謝濤. "A structural and functional study of human catechol-o-methyltransferase gene in Parkinson's disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31239535.

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48

Dantas, Sônia de Sousa. "Entoação e produção de sentidos no discurso do sujeito parkinsoniano." Universidade Católica de Pernambuco, 2006. http://www.unicap.br/tede//tde_busca/arquivo.php?codArquivo=12.

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O estudo da prosódia, especificamente da entoação, vem adquirindo espaço cada vez mais significativo, no campo de pesquisa da aquisição e desenvolvimento da linguagem. As marcas entoacionais, dentro da abordagem interacional, entrelaçam-se com estudos no campo do discurso, descortinando um amplo campo de pesquisa. O presente estudo objetivou trabalhar nesta abordagem, analisando a relação da entoação com a produção de sentidos no discurso do sujeito portador da Doença de Parkinson. Os dados utilizados na presente pesquisa foram coletados com sujeitos que integram a associação do parkinsoniano,

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Dodd, Celia Anne. "Synthetic and Natural Environmental Compounds as Potential Facilitators of Mptp-Induced Parkinsonism." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/26359.

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Abstract:

Parkinson's disease (PD) is a neurodegenerative Lewy body disorder characterized by severe motor deficits, followed by cognitive dysfunction with progression of the disease. Environmental exposure has been suggested as a possible contributor to the development of PD and this view is linked to the discovery of the nigrostriatal neurotoxin MPTP. MPTP can induce dopamine specific degeneration within the basal ganglia often resulting in motor deficits similar to PD. MPTP used in the C57BL/6 mouse is a widely used animal model of PD. The pyrethroid permethrin (PM), and the organophosphate chlorpyri

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Ko, Daniel. "RGS proteins in experimental Parkinsonism and L-DOPA-induced dyskinesia." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/rgs-proteins-in-experimental-parkinsonism-and-ldopainduced-dyskinesia(97c4a365-d9d5-48fb-8ccd-9c653b801427).html.

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Abstract:

Parkinson’s disease (PD) is a progressive neurodegenerative disorder producing a clinical syndrome of bradykinesia, rigidity and resting tremor. These motor symptoms appear due to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) and loss of dopamine in the striatum, which subsequently leads to an imbalance of the basal ganglia motor circuit. The most effective pharmacological treatment for PD is L-3,4-dihydroxyphenylalanine (L-DOPA), the immediate metabolic precursor of dopamine, which effectively restores motor function. L-DOPA is catabolised into dopamine

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