Log in

Relevant bibliographies by topics / Parkinsonian disease / Journal articles

To see the other types of publications on this topic, follow the link: Parkinsonian disease.

Journal articles on the topic 'Parkinsonian disease'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Parkinsonian disease.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Kościołek, Dawid, Michał Urbaś, Jakub Misiak, et al. "The effects that secondary parkinsonian syndromes have on health status." Journal of Education, Health and Sport 53 (January 18, 2024): 148–62. http://dx.doi.org/10.12775/jehs.2024.53.011.

Full text

Abstract:

Introduction and aim of work: The parkinsonian syndrome is a component of Parkinson's disease. A thorough neurological examination can detect symptoms belonging to the parkinsonian syndrome. Diagnosis using the Queen Square Brain Bank criteria is based on the presence of bradykinesia along with one additional symptom in the patient. These include muscle rigidity or resting tremors at a frequency of 4-6 Hz, or postural disturbances that cannot be explained by visual, vestibular, cerebellar, or deep sensory disorders. The parkinsonian syndrome can occur in idiopathic Parkinson's disease, heredit

APA, Harvard, Vancouver, ISO, and other styles

2

Koros, Christos, Evangelia Stanitsa, Efthalia Angelopoulou, Sokratis G. Papageorgiou, and Leonidas Stefanis. "Cognitive Decline in Parkinsonism: From Clinical Phenotypes to the Genetic Background." Biomedicines 13, no. 7 (2025): 1624. https://doi.org/10.3390/biomedicines13071624.

Full text

Abstract:

Background/Objectives: Cognitive impairment often occurs in various parkinsonian syndromes. The course of deficits in cognitive functions ranges from mild cognitive decline to severe deterioration. Affected cognitive domains are also variable. The genetic background of patients exhibiting parkinsonism with concomitant cognitive decline is still elusive. A significant part of current research in Parkinson’s disease and other parkinsonian syndromes is targeted towards the genetic aspects of these disorders. The aim of the present review was to summarize existing studies focusing on the investiga

APA, Harvard, Vancouver, ISO, and other styles

3

Mitchell, Susan L., and Kenneth Rockwood. "Defining Parkinsonism in the Canadian Study of Health and Aging." International Psychogeriatrics 13, S1 (2001): 107–13. http://dx.doi.org/10.1017/s1041610202008049.

Full text

Abstract:

This study sought an operational definition of parkinsonism in elderly people (n = 2,914) who underwent a clinical examination in the Canadian Study of Health and Aging (CSHA). Parkinsonism was defined as having two of the following features: (1) bradykinesia of face or limbs, (2) resting tremor, (3) rigidity, and (4) abnormality of gait and posture. The association of parkinsonism with other parkinsonian-related features (prior diagnosis of Parkinson's disease, use of drugs with extrapyramidal side effects, and use of antiparkinsonian medications) and variables not expected to be related to p

APA, Harvard, Vancouver, ISO, and other styles

4

Mishima, Takayasu, Shinsuke Fujioka, Jiro Fukae, Junichi Yuasa-Kawada, and Yoshio Tsuboi. "Modeling Parkinson’s Disease and Atypical Parkinsonian Syndromes Using Induced Pluripotent Stem Cells." International Journal of Molecular Sciences 19, no. 12 (2018): 3870. http://dx.doi.org/10.3390/ijms19123870.

Full text

Abstract:

Parkinson’s disease (PD) and atypical parkinsonian syndromes are age-dependent multifactorial neurodegenerative diseases, which are clinically characterized by bradykinesia, tremor, muscle rigidity and postural instability. Although these diseases share several common clinical phenotypes, their pathophysiological aspects vary among the disease categories. Extensive animal-based approaches, as well as postmortem studies, have provided important insights into the disease mechanisms and potential therapeutic targets. However, the exact pathological mechanisms triggering such diseases still remain

APA, Harvard, Vancouver, ISO, and other styles

5

Dr. M. Shyam Sundar and Dr. Hemalatha Rendocharakula. "Parkinsonism and Its Clinical Subtypes - An Observational Study in a Tertiary Care Hospital." IAR Journal of Medicine and Surgery Research 4, no. 5 (2023): 8–11. http://dx.doi.org/10.47310/iarjmsr.2023.v04i05.03.

Full text

Abstract:

Background: The term Parkinsonism is defined by any combination of six specific motor features: tremors at rest, bradykinesia, rigidity, loss of postural reflexes, flexed posture, and the freezing phenomenon (where the feet are transiently “glued to the ground”). Not all six of these cardinal features need be present, but at least two should be before the diagnosis of Parkinsonism is made, with at least one of them being tremors at rest or bradykinesia. This study is a hospital based Observational study to understand the prevalence and rank order of subtypes of Parkinsonism. Material and Metho

APA, Harvard, Vancouver, ISO, and other styles

6

Ma, Yilong, Shichun Peng, Phoebe G. Spetsieris, Vesna Sossi, David Eidelberg, and Doris J. Doudet. "Abnormal Metabolic Brain Networks in a Nonhuman Primate Model of Parkinsonism." Journal of Cerebral Blood Flow & Metabolism 32, no. 4 (2011): 633–42. http://dx.doi.org/10.1038/jcbfm.2011.166.

Full text

Abstract:

Parkinson's disease (PD) is associated with a characteristic regional metabolic covariance pattern that is modulated by treatment. To determine whether a homologous metabolic pattern is also present in nonhuman primate models of parkinsonism, 11 adult macaque monkeys with parkinsonism secondary to chronic systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 12 age-matched healthy animals were scanned with [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET). A subgroup comprising five parkinsonian and six control animals was used to identify a parkinsonism-related patte

APA, Harvard, Vancouver, ISO, and other styles

7

Hermida, Adriana P., A. Umair Janjua, Oliver M. Glass, et al. "A case of lithium-induced parkinsonism presenting with typical motor symptoms of Parkinson's disease in a bipolar patient." International Psychogeriatrics 28, no. 12 (2016): 2101–4. http://dx.doi.org/10.1017/s1041610216001101.

Full text

Abstract:

ABSTRACTLithium is a mood stabilizer rarely associated with drug-induced parkinsonism (DIP). We present a case of an elderly woman with bipolar disorder who developed parkinsonian symptoms after chronic lithium administration despite therapeutic serum levels. Upon evaluation, classic parkinsonian signs of muscle rigidity, tremor, bradykinesia, freezing of gait, and cognitive decline were observed. Initially, she was diagnosed with Parkinson's disease (PD); however, DaTscan SPECT imaging clarified the diagnosis as DIP. As the daily lithium dosage was reduced, the patient's motor symptoms improv

APA, Harvard, Vancouver, ISO, and other styles

8

Ebmeier, K. P., S. A. Calder, J. R. Crawford, L. Stewart, R. H. B. Cochrane, and J. A. O. Besson. "Dementia in idiopathic Parkinson's disease: prevalence and relationship with symptoms and signs of Parkinsonism." Psychological Medicine 21, no. 1 (1991): 69–76. http://dx.doi.org/10.1017/s0033291700014665.

Full text

Abstract:

SYNOPSISA whole population cohort of 157 patients with idiopathic Parkinsonism, most of whom had previously been clinically examined by Mutch (1986 a), were assessed to determine prevalence figures for dementia and examine the relationship between dementia, cognitive impairment and Parkinsonian signs. Dementia according to DSM-III-R criteria was diagnosed in 23·3% of all patients (95% confidence interval: 17·1 to 32·4%). Dementia and cognitive impairment were associated with overall measures of Parkinsonian impairment and rigidity, but not tremor, even after controlling for age, sex and educat

APA, Harvard, Vancouver, ISO, and other styles

9

Dal, Shoaib, and Scott Whyte. "035 Valproate-induced parkinsonism ‘an early warning’: case reports and review of literature." Journal of Neurology, Neurosurgery & Psychiatry 90, e7 (2019): A12.2—A12. http://dx.doi.org/10.1136/jnnp-2019-anzan.32.

Full text

Abstract:

IntroductionWe describe two cases of valproate-induced parkinsonism, where the parkinsonian features develop after commencing valproate (VPA), in a time frame and manner well described by previous publications.1 In contrast to the published literature, that has short duration of follow-up, we have had a prolonged follow-up of these two cases, who initially improved on ceasing valproate, but then after a period progressed again, with the development of levodopa-responsive asymmetrical Parkinson’s disease.2Cases67 years old man, on VPA 500 mg twice a day for seizures since 2008, developed new re

APA, Harvard, Vancouver, ISO, and other styles

10

Rasaholiarison, Nomena Finiavana, Jemissair Glorien Lemahafaka, Lala Andriamasinavalona Rajaonarison, Manambina Ratsimandresy, Jenny Larissa Rakotomanana, and Alain Djacoba Tehindrazanarivelo. "Increasing Frequency of Parkinsonian Syndrome as a Reason for Admission to the Neurology Department of Befelatanana University Teaching Hospital, Madagascar." European Scientific Journal, ESJ 18, no. 17 (2022): 129. http://dx.doi.org/10.19044/esj.2022.v18n17p129.

Full text

Abstract:

The number of parkinsonian syndrome patients in Africa is increasing. This study evaluated the increasing number of parkinsonian syndrome (PS) patients admitted to a hospital in Madagascar. A comparison was carried out between parkinsonism syndrome plus (PS+) and idiopathic Parkinson's Disease (PD) cases. Retrospectively, case records of patients with parkinsonism was reviewed between 2009 and 2018 in the Neurology Department of Befelatanana University Teaching Hospital, Antananarivo. Out of the 7343 patients seen in the unit over this period, 157 patients with PS were retained. It was found t

APA, Harvard, Vancouver, ISO, and other styles

11

Raccagni, Cecilia, Jorik Nonnekes, Bastiaan R. Bloem, et al. "Gait and postural disorders in parkinsonism: a clinical approach." Journal of Neurology 267, no. 11 (2019): 3169–76. http://dx.doi.org/10.1007/s00415-019-09382-1.

Full text

Abstract:

Abstract Disturbances of balance, gait and posture are a hallmark of parkinsonian syndromes. Recognition of these axial features can provide important and often early clues to the nature of the underlying disorder, and, therefore, help to disentangle Parkinson’s disease from vascular parkinsonism and various forms of atypical parkinsonism, including multiple system atrophy, progressive supranuclear palsy, and corticobasal syndrome. Careful assessment of axial features is also essential for initiating appropriate treatment strategies and for documenting the outcome of such interventions. In thi

APA, Harvard, Vancouver, ISO, and other styles

12

Nitrini, Ricardo, Luís Sidônio Teixeira da Silva, Sérgio Rosemberg, et al. "Prion disease resembling frontotemporal dementia and parkinsonism linked to chromosome 17." Arquivos de Neuro-Psiquiatria 59, no. 2A (2001): 161–64. http://dx.doi.org/10.1590/s0004-282x2001000200001.

Full text

Abstract:

OBJECTIVE: To compare the clinical features of a familial prion disease with those of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). BACKGROUND: Prion diseases are not usually considered in the differential diagnosis of FTDP-17, since familial Creutzfeldt-Jakob disease (CJD), the most common inherited prion disease, often manifests as a rapidly progressive dementia. Conversely, FTDP-17 usually has an insidious onset in the fifth decade, with abnormal behavior and parkinsonian features. METHOD: We present the clinical features of 12 patients from a family with CJD a

APA, Harvard, Vancouver, ISO, and other styles

13

Vasconcellos, Luiz Felipe Rocha, Sergio A. Pereira Novis, Denise Madeira Moreira, Ana Lucia Z. Rosso, and Ana Claudia C. B. Leite. "Neuroimaging in Parkinsonism: a study with magnetic resonance and spectroscopy as tools in the differential diagnosis." Arquivos de Neuro-Psiquiatria 67, no. 1 (2009): 1–6. http://dx.doi.org/10.1590/s0004-282x2009000100002.

Full text

Abstract:

The differential diagnosis of Parkinsonism based on clinical features, sometimes may be difficult. Diagnostic tests in these cases might be useful, especially magnetic resonance imaging, a noninvasive exam, not as expensive as positron emission tomography, and provides a good basis for anatomical analysis. The magnetic resonance spectroscopy analyzes cerebral metabolism, yielding inconsistent results in parkinsonian disorders. We selected 40 individuals for magnetic resonance imaging and spectroscopy analysis, 12 with Parkinson's disease, 11 with progressive supranuclear palsy, 7 with multiple

APA, Harvard, Vancouver, ISO, and other styles

14

Hruska, Kathleen S., Ozlem Goker-Alpan, and Ellen Sidransky. "Gaucher Disease and the Synucleinopathies." Journal of Biomedicine and Biotechnology 2006 (2006): 1–6. http://dx.doi.org/10.1155/jbb/2006/78549.

Full text

Abstract:

Several recent observations suggest a connection between Gaucher disease, the inherited deficiency of glucocerebrosidase, and the synucleinopathies. Rare patients have been observed who develop both Gaucher disease and parkinsonism. Autopsy studies on these subjects reveal synuclein-positive Lewy bodies and inclusions. An increased incidence of synucleinopathies also has been noted in relatives of Gaucher probands. In complementary studies, screening of patients with parkinsonism has identified a greater than expected frequency of glucocerebrosidase mutations. These glucocerebrosidase mutation

APA, Harvard, Vancouver, ISO, and other styles

15

Sladek, John R., and Don Marshall Gash. "Nerve-cell grafting in Parkinson's disease." Journal of Neurosurgery 68, no. 3 (1988): 337–51. http://dx.doi.org/10.3171/jns.1988.68.3.0337.

Full text

Abstract:

✓ The successful utilization of fetal nerve-cell grafts as therapeutic tools in animal models of neurodegenerative disease has prompted the first clinical attempts in parkinsonian patients in at least three countries. The extensive scientific data in rodents coupled with the first successful fetal neural grafts in monkeys with experimental parkinsonism suggest that consideration might now be given to clinical applications. Attention is also directed to the various types of donor cells that might be utilized in clinical trials for the treatment of parkinsonism, including potential benefits, ris

APA, Harvard, Vancouver, ISO, and other styles

16

Escobar Sanabria, David, Luke A. Johnson, Shane D. Nebeck, et al. "Parkinsonism and vigilance: alteration in neural oscillatory activity and phase-amplitude coupling in the basal ganglia and motor cortex." Journal of Neurophysiology 118, no. 5 (2017): 2654–69. http://dx.doi.org/10.1152/jn.00388.2017.

Full text

Abstract:

Oscillatory neural activity in different frequency bands and phase-amplitude coupling (PAC) are hypothesized to be biomarkers of Parkinson’s disease (PD) that could explain dysfunction in the motor circuit and be used for closed-loop deep brain stimulation (DBS). How these putative biomarkers change from the normal to the parkinsonian state across nodes in the motor circuit and within the same subject, however, remains unknown. In this study, we characterized how parkinsonism and vigilance altered oscillatory activity and PAC within the primary motor cortex (M1), subthalamic nucleus (STN), and

APA, Harvard, Vancouver, ISO, and other styles

17

Bermejo Rey, Cristina. "Parálisis Supranuclear Progresiva: una enfermedad silenciada = Progressive Supranuclear Palsy: a silenced disease." REVISTA ESPAÑOLA DE COMUNICACIÓN EN SALUD 8, no. 2 (2017): 272. http://dx.doi.org/10.20318/recs.2017.4007.

Full text

Abstract:

Resumen: La Parálisis Supranuclear Progresiva es una enfermedad neurodegenerativa, perteneciente al espectro de trastornos parkinsonianos (por tanto es un tipo de parkinsonismo), que no está lo suficientemente visibilizada y para la que, a día de hoy, por desgracia, no existe cura. Descrita en 1972 por Steele, Richardson y Olszewski, se caracteriza por la muerte progresiva de diferentes zonas del cerebro. Los propósitos de este artículo son: dar a conocer esta problemática, relativamente desconocida, mostrar su invisibilidad en los medios y en la sociedad para hacerla más visible, y servir com

APA, Harvard, Vancouver, ISO, and other styles

18

Evans, Andrew H., and Chiun-Hian Chai. "Evaluation of Nonmotor Symptoms in Diagnosis of Parkinsonism and Tremor." Parkinson's Disease 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/9182946.

Full text

Abstract:

Background. Nonmotor symptoms particularly olfactory dysfunction, RBD, depression, hallucinations, and constipation are currently not included in the typical clinical criteria for diagnosing Lewy body Parkinsonian disorders (LBPD). The aim of this study is to determine the diagnostic value of nonmotor symptoms in patients presenting with Parkinsonism and tremor.Methods. All new patients seen between January 2007 and May 2013 in the Movement Disorders Specialist Clinics of the Royal Melbourne Hospital (RMH), who were referred with a possible neurodegenerative syndrome or concerns of Parkinsonis

APA, Harvard, Vancouver, ISO, and other styles

19

Mohanty, Bishnupriya, Ishani Pravin Arlekar, and Anuradha Vinayak Patil. "A REVIEW ON PARKINSONISM: AYURVEDA PERSPECTIVE." International Journal of Research in Ayurveda and Pharmacy 15, no. 4 (2024): 101–3. http://dx.doi.org/10.7897/2277-4343.154127.

Full text

Abstract:

Parkinsonism is a clinical syndrome that consists of four cardinal signs: Tremor, Rigidity, Akinesia and Postural disturbances (TRAP). It is also called as the Shaking Palsy or Paralysis agitans. Parkinson’s disease is a common cause of the TRAP syndrome, but there are numerous other causes which can be considered as the differential diagnosis. Parkinson’s disease specifically refers to patients who have Parkinsonism, without any atypical features and who have essentially normal MRI that excludes other causes for their Parkinsonian symptoms. The main difference between the two is the effect of

APA, Harvard, Vancouver, ISO, and other styles

20

Dorval, Alan D., and Warren M. Grill. "Deep brain stimulation of the subthalamic nucleus reestablishes neuronal information transmission in the 6-OHDA rat model of parkinsonism." Journal of Neurophysiology 111, no. 10 (2014): 1949–59. http://dx.doi.org/10.1152/jn.00713.2013.

Full text

Abstract:

Pathophysiological activity of basal ganglia neurons accompanies the motor symptoms of Parkinson's disease. High-frequency (>90 Hz) deep brain stimulation (DBS) reduces parkinsonian symptoms, but the mechanisms remain unclear. We hypothesize that parkinsonism-associated electrophysiological changes constitute an increase in neuronal firing pattern disorder and a concomitant decrease in information transmission through the ventral basal ganglia, and that effective DBS alleviates symptoms by decreasing neuronal disorder while simultaneously increasing information transfer through the same reg

APA, Harvard, Vancouver, ISO, and other styles

21

Whitlock, F. A. "The Psychiatric Complications of Parkinson's Disease." Australian & New Zealand Journal of Psychiatry 20, no. 2 (1986): 114–21. http://dx.doi.org/10.3109/00048678609161325.

Full text

Abstract:

Although James Parkinson in 1817 excluded mental symptoms from his original description of paralysis agitans, it has become clear that a wide range of psychiatric disorders can develop in patients with this disease. The principal conditions of dementia, depression and confusional syndromes, many of which are precipitated by drugs used in the treatment of parkinsonism, are reviewed. Particular attention is given to the frequency of dementia and its likely pathogenesis, to the nature of depression in Parkinson's disease and to the effects of different drugs, notably levodopa. A number of rare di

APA, Harvard, Vancouver, ISO, and other styles

22

Uitti, Ryan J., A. H. Rajput, B. Rozdilsky, M. Bickis, T. Wollin, and W. K. Yuen. "Regional Metal Concentrations in Parkinson's Disease, Other Chronic Neurological Diseases, and Control Brains." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 16, no. 3 (1989): 310–14. http://dx.doi.org/10.1017/s0317167100029140.

Full text

Abstract:

ABSTRACT:Metal deficiency or toxicity states have been recognized as a cause of several neurological disorders and are suspected in others. We analyzed four brain regions (frontal cortex, caudate nucleus, substantia nigra, and cerebellum) in 36 human brains for concentrations of 24 metals (Ag, Al, As, B, Be, Ca, Cd, Co, Cr, Cu, Fe, K, Pb, Mg, Mn, Mo, Na, Ni, P, Se, Ti, V, W, Zn). Regional metal concentrations, measured using atomic absorption and atomic emission spectroscopy, were compared between 9 Parkinson's disease (PD) brains, 15 brains from patients with other chronic neurological diseas

APA, Harvard, Vancouver, ISO, and other styles

23

Vila-Chã, N., S. Cavaco, A. Mendes, et al. "Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics." Parkinson's Disease 2021 (June 10, 2021): 1–7. http://dx.doi.org/10.1155/2021/5553460.

Full text

Abstract:

Introduction. Pain is a major nonmotor symptom of Parkinson’s disease (PD), and central parkinsonian pain is the core feature of the putative Park pain subtype of PD. This study aimed to explore the cognitive and behavioral profile of PD patients with central parkinsonian pain. Material and Methods. A structured interview was used to identify and characterize pain in a cohort of 260 consecutive PD patients. The Ford classification of pain was applied. The Dementia Rating Scale-2 (DRS-2) and the Impulse Control Disorders in Parkinson’s Disease Short Form (QUIP-S) were administered, and patients

APA, Harvard, Vancouver, ISO, and other styles

24

Frank, J. S., F. B. Horak, and J. Nutt. "Centrally Initiated Postural Adjustments in Parkinsonian Patients On and Off Levodopa." Journal of Neurophysiology 84, no. 5 (2000): 2440–48. http://dx.doi.org/10.1152/jn.2000.84.5.2440.

Full text

Abstract:

This study investigates the effects of parkinsonism and dopamine replacement therapy (levodopa) on centrally initiated postural activity preceding rising onto the toes. The electromyographic (EMG) and force magnitude, scaling, sequencing, and postural stabilization were compared when rising-to-toes under two conditions, slow/low versus fast/high, for parkinsonian patients and elderly control subjects. Parkinsonian subjects were tested after withholding their levodopa medication for 12–16 h and again 1 h after taking their medication when parkinsonian signs were diminished. Parkinsonian subject

APA, Harvard, Vancouver, ISO, and other styles

25

Huot, Philippe, Susan H. Fox, and Jonathan M. Brotchie. "Monoamine Reuptake Inhibitors in Parkinson’s Disease." Parkinson's Disease 2015 (2015): 1–71. http://dx.doi.org/10.1155/2015/609428.

Full text

Abstract:

The motor manifestations of Parkinson’s disease (PD) are secondary to a dopamine deficiency in the striatum. However, the degenerative process in PD is not limited to the dopaminergic system and also affects serotonergic and noradrenergic neurons. Because they can increase monoamine levels throughout the brain, monoamine reuptake inhibitors (MAUIs) represent potential therapeutic agents in PD. However, they are seldom used in clinical practice other than as antidepressants and wake-promoting agents. This review article summarises all of the available literature on use of 50 MAUIs in PD. The co

APA, Harvard, Vancouver, ISO, and other styles

26

Wiltshire, Katie M., Christopher Dunham, Stuart Reid, Roland N. Auer, and Oksana Suchowersky. "Neuronal Intranuclear Inclusion Disease Presenting as Juvenile Parkinsonism." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 37, no. 2 (2010): 213–18. http://dx.doi.org/10.1017/s031716710000994x.

Full text

Abstract:

Background:Diagnostic considerations for juvenile onset Parkinsonism (onset at <21 years of age) include juvenile Huntington disease, Wilson disease, dentatorubral-pallidoluysian atrophy (DRPLA), storage diseases, and mitochondrial cytopathies. Neuronal Intranuclear Inclusion Disease (NIID) must also be considered.Case Report:We present a case of juvenile onset NIID with a predominantly Parkinsonian presentation, followed later by corticospinal, cerebellar, and lower motor neuron symptoms.Conclusion:Diagnosis of NIID can be made antemortem through rectal biopsy, however it was missed in thi

APA, Harvard, Vancouver, ISO, and other styles

27

Benazzouz, A., B. Piallat, Z. G. Ni, A. Koudsie, P. Pollak, and A. L. Benabid. "Implication of the Subthalamic Nucleus in the Pathophysiology and Pathogenesis of Parkinson's Disease." Cell Transplantation 9, no. 2 (2000): 215–21. http://dx.doi.org/10.1177/096368970000900207.

Full text

Abstract:

The subthalamic nucleus (STN) has been shown to play an important role in the control of movement and has been considered as a key structure in the functional organization of the basal ganglia. Several studies postulated that the STN plays a critical role in the pathophysiology of Parkinson's disease and that its inhibition or its lesioning can reverse the cardinal motor symptoms. Nevertheless, the beneficial effect was accompanied by dyskinetic abnormal movements. In order to avoid unpleasant and irreversible side effects we used high-frequency stimulation (HFS) of the STN instead of lesions.

APA, Harvard, Vancouver, ISO, and other styles

28

Strafella, A., P. Ashby, A. Lozano, and A. E. Lang. "Pallidotomy Increases Cortical Inhibition in Parkinson's Disease." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 24, no. 2 (1997): 133–36. http://dx.doi.org/10.1017/s0317167100021466.

Full text

Abstract:

ABSTRACT:Background:Pallidotomy helps parkinsonian symptoms. We tested the hypothesis that this might be due to changes in inhibition in the motor cortex.Methods:We examined 15 patients with parkinsonism before and after posteroventral pallidotomy. Magnetic stimuli were delivered over the motor cortex, while subjects maintained a 30% maximum voluntary contraction of the contralateral first dorsal interosseus (FDI).Results:Weak stimuli inhibited voluntary muscle activity, while slightly stronger stimuli caused short latency facilitation from activation of the corticospinal neurons. After pallid

APA, Harvard, Vancouver, ISO, and other styles

29

Sadykova, G. K., R. A. Postanogov, V. P. Kutsenko, et al. "TOWARDS A RADIOLOGICAL DIAGNOSIS OF PARKINSON'S DISEASE." Bulletin of the Medical Institute of Continuing Education 3, no. 4 (2023): 80–86. http://dx.doi.org/10.36107/2782-1714_2023-3-4-80-86.

Full text

Abstract:

Neurodegenerative diseases represent a wide range of diseases, different in nature, caused by disorganization of individual groups of nerve cells and manifested by motor and cognitive disorders. Ones of the most common diseases in this group are diseases with parkinsonian syndrome, primarily Parkinson's disease (primary parkinsonism). This disease, affecting representatives of the older age group, is characterized by a steadily progressing neurological defecit, and as a consequence, a dramatic decrease in the quality and expectancy of life. In this regard, a radiologist must be able to recogni

APA, Harvard, Vancouver, ISO, and other styles

30

Belokoskova, Svetlana G., and Sergei G. Tsikunov. "Activation of V2 vasopressin receptors induces recovery of motor function in patients with stroke, Parkinson’s disease and parkinsonism of different nature." Reviews on Clinical Pharmacology and Drug Therapy 14, no. 4 (2016): 52–60. http://dx.doi.org/10.17816/rcf14452-60.

Full text

Abstract:

In clinical trials have studied effectiveness of agonist of V2 vasopressin receptors, 1-dezamino-8-D-arginine-vasopressin (DDAVP) in correction of movement disorders in patients with stroke, Parkinson’s disease and parkinsonism. Therapy received 15 patients with the stroke and 21 patients with the Parkinson’s disease and parkinsonism. Positive effect of therapy was observed in 67% of cases of stroke and in 73% cases of parkinsonian syndrome. After therapy of DDAVP movement disorders were regressed in patients with light hemiparesis after stroke. In patients with a tremor-rigid shape and akinet

APA, Harvard, Vancouver, ISO, and other styles

31

Wang, Jing, Luke A. Johnson, Alicia L. Jensen, et al. "Network-wide oscillations in the parkinsonian state: alterations in neuronal activities occur in the premotor cortex in parkinsonian nonhuman primates." Journal of Neurophysiology 117, no. 6 (2017): 2242–49. http://dx.doi.org/10.1152/jn.00011.2017.

Full text

Abstract:

A number of studies suggest that Parkinson’s disease (PD) is associated with alterations of neuronal activity patterns in the basal-ganglia-thalamocortical circuit. There are limited electrophysiological data, however, describing how the premotor cortex, which is involved in movement and decision-making, is likely impacted in PD. In this study, spontaneous local field potential (LFP) and single unit neuronal activity were recorded in the dorsal premotor area of nonhuman primates in both the naïve and parkinsonian state using the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of park

APA, Harvard, Vancouver, ISO, and other styles

32

Marsili, Luca, Matteo Bologna, Maja Kojovic, Alfredo Berardelli, Alberto J. Espay, and Carlo Colosimo. "Dystonia in atypical parkinsonian disorders." Parkinsonism & Related Disorders 66 (July 23, 2019): 25–33. https://doi.org/10.1016/j.parkreldis.2019.07.030.

Full text

Abstract:

Dystonia is common in the classic atypical parkinsonian disorders such as multiple system atrophy, progressive supranuclear palsy and corticobasal degeneration, and to a lesser extent in dementia with Lewy bodies. Its clinical phenomenology, including body distribution, timing of appearance, severity, and relationship to dopaminergic and other medications may vary considerably within and between atypical parkinsonian disorders. From a pathophysiological standpoint, the coexistence of dystonia with parkinsonism challenges the functional model of the basal ganglia. Clinical recognition of specif

APA, Harvard, Vancouver, ISO, and other styles

33

Prasuhn, Jannik, and Norbert Brüggemann. "Gene Therapeutic Approaches for the Treatment of Mitochondrial Dysfunction in Parkinson’s Disease." Genes 12, no. 11 (2021): 1840. http://dx.doi.org/10.3390/genes12111840.

Full text

Abstract:

Background: Mitochondrial dysfunction has been identified as a pathophysiological hallmark of disease onset and progression in patients with Parkinsonian disorders. Besides the overall emergence of gene therapies in treating these patients, this highly relevant molecular concept has not yet been defined as a target for gene therapeutic approaches. Methods: This narrative review will discuss the experimental evidence suggesting mitochondrial dysfunction as a viable treatment target in patients with monogenic and idiopathic Parkinson’s disease. In addition, we will focus on general treatment str

APA, Harvard, Vancouver, ISO, and other styles

34

Tremey, A., I. de Chazeron, G. Brousse, and P. M. Llorca. "Punding in Parkinson's disease: To a better understanding of a common phenomenon between Parkinson's disease and addictions." European Psychiatry 33, S1 (2016): S145. http://dx.doi.org/10.1016/j.eurpsy.2016.01.251.

Full text

Abstract:

IntroductionPunding is a stereotypical motor behaviour characterized by a repetitive, excessive and non-goal oriented activity that causes an important loss of time. Since its first description in psychostimulant addicts, data on punding has only derived from studies on Parkinsonian patients treated with dopaminergic drugs. Little is known in the literature about Parkinsonian patient's characteristics who suffer from punding.ObjectiveWe propose to study characteristics of Parkinsonian “punders” in order to investigate the pathophysiology of this phenomenon.MethodsIn this retrospective study, w

APA, Harvard, Vancouver, ISO, and other styles

35

Mercer, Christine. "The impact of non-motor manifestations of Parkinson's disease on partners: understanding and application of chronic sorrow theory." Journal of Primary Health Care 7, no. 3 (2015): 221. http://dx.doi.org/10.1071/hc15221.

Full text

Abstract:

INTRODUCTION: Parkinson's disease (PD) can cause many emotions, including grief and a sense of isolation for both the person with PD (referred to as Parkinsonian) and their partner. Such ongoing grief and emotional turmoil can be termed chronic sorrow. The aim of this research is to present accounts of partners' perspectives, analysed in the context of chronic sorrow theory, to offer health professionals an insight into the impact of non-motor PD symptoms on partners. METHODS: A group of partners of Parkinsonians provided the data through individual stories. These stories were subjected to the

APA, Harvard, Vancouver, ISO, and other styles

36

Prange, Stéphane, Hendrik Theis, Magdalena Banwinkler, and Thilo van Eimeren. "Molecular Imaging in Parkinsonian Disorders—What’s New and Hot?" Brain Sciences 12, no. 9 (2022): 1146. http://dx.doi.org/10.3390/brainsci12091146.

Full text

Abstract:

Neurodegenerative parkinsonian disorders are characterized by a great diversity of clinical symptoms and underlying neuropathology, yet differential diagnosis during lifetime remains probabilistic. Molecular imaging is a powerful method to detect pathological changes in vivo on a cellular and molecular level with high specificity. Thereby, molecular imaging enables to investigate functional changes and pathological hallmarks in neurodegenerative disorders, thus allowing to better differentiate between different forms of degenerative parkinsonism, improve the accuracy of the clinical diagnosis

APA, Harvard, Vancouver, ISO, and other styles

37

Bueno Sanya, L., A. Bermejo Pastor, H. Andreu Gracia, O. De Juan Viladegut, L. Olivier Mayorga, and I. Pacchiarotti. "The use of pramipexole in drug-induced parkinsonism: A case study on a patient with bipolar depression." European Psychiatry 65, S1 (2022): S411—S412. http://dx.doi.org/10.1192/j.eurpsy.2022.1044.

Full text

Abstract:

Introduction Pramipexole is a dopaminergic agonist used in the treatment of Parkinson’s disease and restless leg syndrome. Although there is a lack of pharmacological options to treat drug-induced parkinsonism, not many studies have been made on the use of pramipexole in its management. There is also evidence on pramipexole effectiveness on major depressive episodes, particularly for bipolar and treatment-resistant depression. Objectives To describe a case of drug-induced parkinsonism treated with pramipexole in a complex patient with bipolar disorder type I and obsessive-compulsive disorder,

APA, Harvard, Vancouver, ISO, and other styles

38

Viveros-Martínez, Iraís, Cristofer Zarate-Calderon, Donají Chi-Castañeda, et al. "Characterizing Secondary and Atypical Parkinsonisms: Defining Features and Clinical Variability." Neuroglia 5, no. 4 (2024): 467–87. http://dx.doi.org/10.3390/neuroglia5040030.

Full text

Abstract:

Parkinsonism is a clinical syndrome characterized by akinesia/bradykinesia, muscle rigidity, resting tremor, and postural instability. Within the group of parkinsonisms is Parkinson’s disease, also known as neurodegenerative parkinsonian syndrome. The group of atypical parkinsonisms was established due to the existence of sporadic parkinsonisms that do not share the exact etiology of Parkinson’s disease. Additionally, parkinsonisms that arise from causes other than neurodegeneration have been classified as secondary parkinsonisms. With this in mind, given the diversity of etiologies that can t

APA, Harvard, Vancouver, ISO, and other styles

39

Ota, Miho, Yasuhiro Nakata, Kimiteru Ito, et al. "Differential Diagnosis Tool for Parkinsonian Syndrome Using Multiple Structural Brain Measures." Computational and Mathematical Methods in Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/571289.

Full text

Abstract:

Clinical differentiation of parkinsonian syndromes such as the Parkinson variant of multiple system atrophy (MSA-P) and cerebellar subtype (MSA-C) from Parkinson's disease is difficult in the early stage of the disease. To identify the correlative pattern of brain changes for differentiating parkinsonian syndromes, we applied discriminant analysis techniques by magnetic resonance imaging (MRI). T1-weighted volume data and diffusion tensor images were obtained by MRI in eighteen patients with MSA-C, 12 patients with MSA-P, 21 patients with Parkinson’s disease, and 21 healthy controls. They were

APA, Harvard, Vancouver, ISO, and other styles

40

Respondek, G., J. Levin, and G. Höglinger. "Redefinition of Atypical Parkinsonian Syndromes." Neurology International Open 01, no. 01 (2017): E2—E7. http://dx.doi.org/10.1055/s-0043-101149.

Full text

Abstract:

AbstractThe definition of atypical parkinsonian syndromes is undergoing a change. The umbrella concept of atypical parkinsonian syndromes includes diseases with different underlying pathologies. These are, on the one hand, multiple system atrophy (MSA) and dementia with Lewy bodies (DLB), both of which are characterized by intracellular aggregates of the protein alpha-synuclein, and on the other hand, corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), which are characterized by aggregates of the protein tau. The current syndrome-based classification of these diseases no

APA, Harvard, Vancouver, ISO, and other styles

41

Bor-Seng-Shu, Edson, José Luiz Pedroso, Daniel Ciampi de Andrade, et al. "Transcranial sonography in Parkinson's disease." Einstein (São Paulo) 10, no. 2 (2012): 242–46. http://dx.doi.org/10.1590/s1679-45082012000200022.

Full text

Abstract:

Transcranial sonography has become a useful tool in the differential diagnosis of parkinsonian syndromes. This is a non-invasive, low cost procedure. The main finding on transcranial sonography in patients with idiopathic Parkinson's disease is an increased echogenicity of the mesencephalic substantia nigra region. This hyperechogenicity is present in more than 90% of cases, and reflects a dysfunction in the dopaminergic nigrostriatal pathway. This study discussed how the hyperechogenicity of the substantia nigra may facilitate the differential diagnosis of parkinsonian syndromes.

APA, Harvard, Vancouver, ISO, and other styles

42

Nuzhnyi, E. P., E. Yu Fedotova, A. N. Moskalenko, and S. N. Illarioshkin. "Difficulties in differential diagnosis of chronic tick-borne encephalitis and progressive supranuclear palsy." Russian neurological journal 27, no. 1 (2022): 88–93. http://dx.doi.org/10.30629/2658-7947-2022-27-1-88-93.

Full text

Abstract:

The article presents two clinical cases of 51 and 57-year-old patients living in regions endemic for tick-borne encephalitis in which the differential diagnosis between progressive supranuclear palsy (PSP) and the extremely rare parkinsonian variant of chronic tick-borne encephalitis (CTBE) resulted in a diagnostic challenge. In both cases there was a clinical presentation of progressive symmetric levodopa-resistant parkinsonism with vertical gaze palsy, cognitive impairment of the executive type, frontal lobe signs, focal dystonia and in one case — early onset of postural instability, which c

APA, Harvard, Vancouver, ISO, and other styles

43

Plata, Víctor, Mariana Duhne, Jesús E. Pérez-Ortega, Janet Barroso-Flores, Elvira Galarraga, and José Bargas. "Direct Evaluation of L-DOPA Actions on Neuronal Activity of Parkinsonian TissueIn Vitro." BioMed Research International 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/519184.

Full text

Abstract:

Physiological and biochemical experimentsin vivoandin vitrohave explored striatal receptor signaling and neuronal excitability to posit pathophysiological models of Parkinson's disease. However, when therapeutic approaches, such as dopamine agonists, need to be evaluated, behavioral tests using animal models of Parkinson's disease are employed. To our knowledge, recordings of population neuronal activityin vitroto assess anti-Parkinsonian drugs and the correlation of circuit dynamics with disease state have only recently been attempted. We have shown that Parkinsonian pathological activity of

APA, Harvard, Vancouver, ISO, and other styles

44

Ashwin, Gnanabaskaran, Alan R. Hirsch, Ananda K. Kondepati, and Shalini D. Pasumarthi. "Cogwheel Rigidity in Subacute Combined Degeneration Unresponsive to Vitamin B12 Therapy." CNS Spectrums 29, no. 5 (2024): 480. https://doi.org/10.1017/s1092852924001275.

Full text

Abstract:

IntroductionParkinsonian symptoms seen with B12 deficiency have been described in five cases where B12 therapy has led to their elimination. Subacute combined degeneration (SCD) presenting with parkinsonian signs of cogwheel rigidity, unresponsive to B12 supplementation, has not heretofore been described.MethodsCase Study: This 62-year-old right-handed woman with a past medical history of hypothyroidism presented with complaints of trouble with memory. Cogwheel rigidity and pernicious anemia with low intrinsic factor and B12 levels (165 pg/ml) were found. SCD was diagnosed and treated with mon

APA, Harvard, Vancouver, ISO, and other styles

45

Ko, Ji Hyun, Chong Sik Lee, and David Eidelberg. "Metabolic network expression in parkinsonism: Clinical and dopaminergic correlations." Journal of Cerebral Blood Flow & Metabolism 37, no. 2 (2016): 683–93. http://dx.doi.org/10.1177/0271678x16637880.

Full text

Abstract:

Little is known of the precise relationship between the expression of disease-related metabolic patterns and nigrostriatal dopaminergic dysfunction in parkinsonism. We studied 51 subjects with Parkinson's disease (PD) (18 non-demented, 24 demented, and 9 dementia with Lewy bodies) and 127 with atypical parkinsonian syndromes (47 multiple system atrophy (MSA), 38 progressive supranuclear palsy (PSP), and 42 corticobasal syndrome (CBS)) with 18F-fluorodeoxyglucose PET to quantify the expression of previously validated disease-related patterns for PD, MSA, PSP, and CBS and 18F-fluoropropyl-β-CIT

APA, Harvard, Vancouver, ISO, and other styles

46

Sugg, Elizabeth, Lei Gao, David Bennett, et al. "1020 ◻Rest-activity Rhythm Linked to Parkinsonism in Older Adults: Results from the Rush Memory and Aging Project." SLEEP 47, Supplement_1 (2024): A438—A439. http://dx.doi.org/10.1093/sleep/zsae067.01020.

Full text

Abstract:

Abstract Introduction While the inter-relationship between parkinsonism and Parkinson’s disease (PD) in older adults remains unclear, both phenotypes are related to PD pathology. Adults with PD commonly exhibit nonmotor symptoms such as disturbances in sleep-wake cycles or rest-activity rhythm (RAR). In a previous study of older men, RAR disturbances preceded the development of PD. This current study examines whether RAR disturbances are associated with incident parkinsonism in a cohort of older community-dwelling men and women. Methods We examined 999 older adults (age=80.1; 76% female) in th

APA, Harvard, Vancouver, ISO, and other styles

47

Haas, Carola A. "Revisiting brain stimulation in Parkinson’s disease." Science 374, no. 6564 (2021): 153–54. http://dx.doi.org/10.1126/science.abl9915.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Chua, MPW, KM McLaughlin, and SB Rochow. "Hypomagnesaemia induced Parkinsonism?" Journal of the Royal College of Physicians of Edinburgh 37, no. 3 (2007): 202–4. https://doi.org/10.1177/1478271520073703025.

Full text

Abstract:

We report an unusual presentation in an elderly woman with a previous diagnosis of benign tremulous Parkinson’s disease who developed a severe Parkinsonian-like syndrome with profound immobility following small bowel resection. Her Parkinsonism was largely unresponsive to conventional medical therapy. However, she was found to be profoundly hypomagnesaemic and a dramatic improvement in her symptoms and functional ability was achieved after correction of the severe hypomagnesaemia. A brief discussion is included.

APA, Harvard, Vancouver, ISO, and other styles

49

Oveisgharan, Shahram, Lei Yu, Robert J. Dawe, David A. Bennett, and Aron S. Buchman. "Total Daily Physical Activity and the Risk of Parkinsonism in Community-Dwelling Older Adults." Journals of Gerontology: Series A 75, no. 4 (2019): 702–11. http://dx.doi.org/10.1093/gerona/glz111.

Full text

Abstract:

Abstract Background Physical activity is a modifiable risk factor associated with health benefits. We hypothesized that a more active lifestyle in older adults is associated with a reduced risk of incident parkinsonism and a slower rate of its progression. Methods Total daily physical activity was recorded with an activity monitor in 889 community-dwelling older adults participating in the Rush Memory and Aging Project. Four parkinsonian signs were assessed with a modified motor portion of the Unified Parkinson’s Disease Rating Scale and summarized as a categorical measure and continuous globa

APA, Harvard, Vancouver, ISO, and other styles

50

Mahmoudi, Romina, Stephan Greten, Linda Veith Sanches, et al. "Impact of the Anticholinergic Burden on Disease-Specific Symptoms in Parkinsonian Syndromes." Brain Sciences 14, no. 8 (2024): 805. http://dx.doi.org/10.3390/brainsci14080805.

Full text

Abstract:

Background: Anticholinergic adverse effects pose a relevant threat to patients, in particular elderly and cognitively impaired patients. Patients with Parkinsonian syndromes are especially at risk from anticholinergic adverse effects due to the often-required complex drug therapy. Aims: The aim of this study was to evaluate the potential effect of the anticholinergic burden on motor and non-motor symptoms in Parkinson’s disease and atypical Parkinsonian syndromes. Methods: This cross-sectional, monocentric retrospective data analysis included 151 patients with Parkinson’s disease (PD), 63 with

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!