Log in

Relevant bibliographies by topics / Pathogenetic mechanisms / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Pathogenetic mechanisms.

Dissertations / Theses on the topic 'Pathogenetic mechanisms'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Pathogenetic mechanisms.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Booler, Helen. "Pathogenetic mechanisms in the dystroglycanopathies pathogenesis." Thesis, Royal Veterinary College (University of London), 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669190.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Törnblom, Hans. "Pathogenetic mechanisms in irritable bowel syndrome /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-287-3/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Pappa, Anastasia. "Pathogenetic mechanisms in thyroid-associated ophthalmopathy." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299354.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Orsetti, Valeria. "Pathogenetic mechanisms in motor neuron diseases." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3421997.

Full text

Abstract:

Amyotrophic Lateral Sclerosis, ALS, and Spinal and Bulbar Muscular Atrophy, SBMA (or Kennedy’s disease, KD) are two rare degenerative disorders of nervous system, characterized by early involvement of motor neurons. ALS is characterized by degeneration and death of upper and lower motor neurons, which leads to generalized muscle weakness and atrophy, speech and swallowing disabilities, and progressive paralysis until death is caused by respiratory failure. Its pathogenesis is still unknown. KD is an inherited X-linked motor neuronal disorder caused by an abnormal expansion of a trinucleotide C

APA, Harvard, Vancouver, ISO, and other styles

5

Guadagnin, Eleonora. "Pathogenetic Mechanisms of Collagen Type VI-Related Muscular Dystrophies." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424331.

Full text

Abstract:

The overall focus of thesis is determining key disease-driving molecular pathways involved in the progression of a specific subtype of neuromuscular diseases, the collagen type VI-related muscular dystrophies (COL6RD). These kinds of muscular disorder encompass a wide spectrum of diseases, ranging from the severe Ullrich muscular dystrophy (UCMD) to the mild Bethlem myopathy (BM), characterized by a plethora of clinical manifestations. Both UCMD and BM usually arise at birth or early childhood with hypotonia and progressive muscle weakness, joint contractures and hyperlaxity of the distal join

APA, Harvard, Vancouver, ISO, and other styles

6

Gunnarsson, Iva. "SLE : pathogenetic mechanisms in nephritis and sulphasalazine-induced lupus reactions /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3654-4/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Tymofiychuk, I. R. "Sex hormones participation in the pathogenetic mechanisms of Alzheimer's disease." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18014.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Pancrazi, Laura. "Foxg1: intracellular localization and possible pathogenetic mechanisms in Rett syndrome." Doctoral thesis, Scuola Normale Superiore, 2014. http://hdl.handle.net/11384/85985.

Full text

Abstract:

The Forkhead box G1 (FoxG1) is a transcription factor essential for the forebrain development and involved in pathogenesis of Rett syndrome. Notwithstanding the importance of this protein, little is known about the modalities by which it exerts its cellular functions. In this thesis I investigated, in cell culture and in animal model, the molecular mechanisms of Foxg1 action and the pathophysiological consequences of Foxg1 haploinsufficiency. Using fluorescence recovery after photobleaching strategy, I investigated the chromatin binding dynamics of Foxg1 in its wild-type form or carrying som

APA, Harvard, Vancouver, ISO, and other styles

9

Kvasnytska, О. В. "Pathogenetic mechanisms of functional renal impairment in patients with chronic hepatitis." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18593.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Bua, Gloria <1987&gt. "Parvovirus B19: Virus-Cell Interactions, Pathogenetic Mechanisms and Development of Compounds with Antiviral Activity." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7624/1/PhDthesis_BUA.pdf.

Full text

Abstract:

The pathogenic Parvovirus B19 is characterized by a strict adaptation to erythroid progenitor cells (EPCs), a heterogeneous population of differentiating cells. The aim of the work was the characterization of B19V infection dynamics in EPCs in dependence on the cell differentiation stage, in terms of distribution of infected cells, synthesis of viral nucleic acids and production of infectious virus. EPCs at early differentiation stage led to an abortive infection, without viral replication. EPCs at later stages were permissive, with highest levels of viral replicative activity at day 9 and low

APA, Harvard, Vancouver, ISO, and other styles

11

De, Maria Michela. "Identification of novel pathogenetic mechanisms, genotype-phenotype correlations and pharmacological approaches in early-onset epilepsies." Doctoral thesis, Università degli studi del Molise, 2017. http://hdl.handle.net/11695/73145.

Full text

Abstract:

Le subunità Kv7.2 (kcnq2) e Kv7.3 (kcnq3) formano un canale tetramerico che sottende una corrente del K+ coinvolta nella regolazione dell’eccitabilità neuronale. Ciascuna subunità è costituita da 6 segmenti transmembrana (S1-S6) e da una lunga coda intracellulare al C-terminale: i segmenti da S1 a S4 formano il dominio del sensore del voltaggio (VSD), mentre i segmenti S5-S6 ed il loop di connessione formano la regione poro. Mutazioni nel gene kcnq2 sono state inizialmente associate a Convulsioni Benigne Familiari Neonatali e più recentemente anche ad Encefalopatia Epilettica a insorgenza prec

APA, Harvard, Vancouver, ISO, and other styles

12

Fossati, S. "Acute cardiovascular effects of exposure to airborne particulate matter : a study of possible pathogenetic mechanisms." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/64549.

Full text

Abstract:

Introduction Increased levels of particulate matter air pollution (PM) have been associated with increased cardiovascular morbidity and mortality, especially in elderly adults and in people suffering from cardiovascular or lung diseases. The mechanisms behind these effects are still unknown, although some hypothesis have been postulated that include a modification of autonomic regulation of heart rhythm and the induction of arrhythmic events. Which fraction of PM is the most harmful is still controversial, and few studies investigated the role of personal exposure to different fractions, and

APA, Harvard, Vancouver, ISO, and other styles

13

Patton, William P. "Chemical and photic damage to DNA as pathogenetic mechanisms in the aetiology of macular degeneration of the eye." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284393.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

GUARNIERI, GIULIA. "Human cholinergic neurons from nucleus basalis of Meynert: a new promising tool to study pathogenetic mechanisms affecting neurogenesis." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1072770.

Full text

Abstract:

The degeneration of basal forebrain cholinergic neurons within the nucleus basalis of Meynert (NBM) is responsible for the cognitive decline in neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Indeed, the major therapeutic strategies have been directed toward the cholinergic system. However, no effective therapies exist to contrast NBM cholinergic neuron loss and investigations in the field are strongly restricted by the lack of human models. Thus, the work of this thesis firstly contributed to establish and characterise a novel primary culture of c

APA, Harvard, Vancouver, ISO, and other styles

15

Lindell, Gert. "Smoking and peptic ulcer disease a clinical and experimental study with special reference to possible pathogenetic mechanisms induced by smoking /." Lund : Dept. of Surgery, Lund University, 1992. http://books.google.com/books?id=YT9sAAAAMAAJ.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Han, Qian, and 韩茜. "Effects of intermittent hypoxia and hyperlipidemia-in vivo and in vitro studies on pathogenetic mechanisms linking obstructive sleepapnea to cardiovascular disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46918371.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Alsam, Selwa. "The mechanisms associated with Acanthamoeba pathogenesis." Thesis, Birkbeck (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499995.

Full text

Abstract:

Acanthamoeba is an opportunistic protozoan pathogen that can cause fatal granulomatous encephalitis and a sight-threatening keratitis. However, the pathogenic mechanisms associated with Acanthamoeba infections remain unclear. One of the primary requirement in Acanthamoeba encephalitis is the haematogenous spread, followed by invasion of the blood-brain barrier. Using human brain microvascular endothelial cells (HBMEC) which constitute the blood-brain barrier, here we studied Acanthamoeba interactions with HBMEC. The results revealed that Acanthamoeba binds to HBMEC and adhesion can be blocked

APA, Harvard, Vancouver, ISO, and other styles

18

Behan, W. M. H. "Immunologic mechanisms in the pathogenesis of polymyositis." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356298.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Cramer, Robert Andrew. "Molecular dissection of Alternaria brassicicola pathogenesis mechanisms." Access citation, abstract and download form; downloadable file 12.34 Mb, 2004. http://wwwlib.umi.com/dissertations/fullcit/3131666.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Павлов, С. Б. "Механізми участі фізіологічної системи сполучної тканини у формуванні патологічних процесів". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/55191.

Full text

Abstract:

Дисертація присвячена вирішенню актуальної проблеми встановлення ролі стереотипних реакцій сполучної тканини як фізіологічної системи в розвитку патологічного процесу. Сформульовані загальні принципи оцінки стану фізіологічної системи сполучної тканини та визначена її роль у розвитку патологічного процесу в паренхіматозних органах (нирки, печінка, підшлункова залоза) і кістковій тканині. Вперше вивчена роль регуляторного шляху RANK-RANKL-OPG при експериментальному моделюванні патології нирок, встановлена його активація та наявність взаємозв'язку з про- та протизапальними цитокінами, у тому чис

APA, Harvard, Vancouver, ISO, and other styles

21

Johnson, Corey S. Sulik Kathleen K. "Pathogenesis and mechanisms of ethanol-induced limb defects." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,683.

Full text

Abstract:

Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Cell and Developmental Biology." Discipline: Cell and Developmental Biology; Department/School: Medicine.

APA, Harvard, Vancouver, ISO, and other styles

22

Mutsaers, Chantal. "Mechanisms of disease pathogenesis in Spinal Muscular Atrophy." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9774.

Full text

Abstract:

Low levels of survival motor neuron (SMN) protein cause the autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA), through mechanisms that are poorly defined. SMN protein is ubiquitously expressed, however the major pathological hallmarks of SMA are focused on the neuromuscular system, including a loss of lower motor neurons in the ventral horn of the spinal cord and atrophy of skeletal muscle. At present there is no cure for SMA. Most research to date has focused on examining how low levels of SMN lead to pathological changes in motor neurons, therefore the contribution

APA, Harvard, Vancouver, ISO, and other styles

23

Kennedy, Richard Lee. "Immunological mechanisms in the pathogenesis of autoimmune thyrotoxicosis." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/19894.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Thairu, Ngayu Munga. "Mechanisms of colorectal cancer pathogenesis : role of hypoxia." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14361.

Full text

Abstract:

Colorectal cancer (CRC) is the third most common cancer worldwide Hypoxia plays a pivotal role in cancer, regulating cellular processes such as angiogenesis via the Hypoxia Inducible Factor (HIF) pathway. HIF-1α and HIF-2α, isoforms of the α-subunit, were previously thought to be functionally redundant, but mounting evidence supports their divergent roles in many cancers. In CRC their relative roles remain unclear. This study aimed to elucidate their relative contribution to hypoxic regulation of CRC using the Caco-2 cell-line. Ex vivo cultures of primary cells isolated from CRC tissue were us

APA, Harvard, Vancouver, ISO, and other styles

25

Cortese, Matteo. "Cellular and molecular mechanisms of Usher syndrome pathogenesis." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066390/document.

Full text

Abstract:

Le syndrome d’Usher (USH) cause une surdité-cécité chez l’homme. Au moins neuf gènes responsables ont été identifiés. L’origine de l’atteinte auditive a été dévoilée par l’analyse de souris mutantes, mais les causes de la cécité sont encore obscures. Néanmoins, unes des protéines de Usher, la myosine VIIa, a été impliquée dans le transport intracellulaire dans les photorécepteurs. Pour mieux comprendre le rôle dans la rétine, j’ai étudié l’un de ses partenaires, la spectrine βV. Nous avons conclu que cette spectrine, en collaboration avec les protéines USH1, est impliquée dans le trafic cellul

APA, Harvard, Vancouver, ISO, and other styles

26

Cortese, Matteo. "Cellular and molecular mechanisms of Usher syndrome pathogenesis." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066390.pdf.

Full text

Abstract:

Le syndrome d’Usher (USH) cause une surdité-cécité chez l’homme. Au moins neuf gènes responsables ont été identifiés. L’origine de l’atteinte auditive a été dévoilée par l’analyse de souris mutantes, mais les causes de la cécité sont encore obscures. Néanmoins, unes des protéines de Usher, la myosine VIIa, a été impliquée dans le transport intracellulaire dans les photorécepteurs. Pour mieux comprendre le rôle dans la rétine, j’ai étudié l’un de ses partenaires, la spectrine βV. Nous avons conclu que cette spectrine, en collaboration avec les protéines USH1, est impliquée dans le trafic cellul

APA, Harvard, Vancouver, ISO, and other styles

27

Li, Bin, and 李斌. "ID1-induced activation of PI3K/AKT/NFkB pathway: mechanisms and significance in esophageal cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43783880.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Prinz, Jonathan Franklin. "Physical mechanisms in the pathogenesis of temporomandibular joint sounds." Thesis, Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17310805.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Chang, Kai-Hsin 1974. "Erythropoietin, erythropoiesis, and malarial anemia : the mechanisms and implications of insufficient erythropoiesis during murine blood-stage malaria." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84490.

Full text

Abstract:

Severe anemia is a major life-threatening complication of malaria. Inappropriately low reticulocytosis in malaria patients with anemia suggests insufficient erythropoiesis, of which the mechanisms and implications are not clear. The principle growth factor that promotes erythropoiesis is erythropoietin (Epo). Studies determining the serum level of Epo in malaria infected patients have been inconclusive. Furthermore, the role of Epo and the erythropoietic response to Epo stimulation during malaria have never been examined. The purpose of the experiments performed in this thesis was, thus

APA, Harvard, Vancouver, ISO, and other styles

30

Iancu, Simona Ioana. "Epithelial mechanisms in the microbial pathogenesis of periodontal disease." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/epithelial-mechanisms-in-the-microbial-pathogenesis-of-periodontal-disease(90dedf1b-d1dd-455b-92ff-47c8af10b995).html.

Full text

Abstract:

Periodontitis, a major cause of tooth loss, is a bacterially induced inflammatory disease that has been associated with certain bacterial species. The aim of this thesis was to identify the epithelial mechanisms activated by commensal and periodontal pathogens to determine which signalling pathways, transcription factors, and pro-inflammatory cytokine responses are associated with periodontitis. The H400 gingival epithelial cell line was infected with the health-associated Actinomyces naeslundii and periodontopathogens Fusobacterium nucleatum and Porphyromonas gingivalis. Differential pathway

APA, Harvard, Vancouver, ISO, and other styles

31

Martin, Nicole C. Couillard Nicole. "Differential dengue tropism & neutralization : potential mechanisms of pathogenesis /." Download the dissertation in PDF, 2006. http://www.lrc.usuhs.mil/dissertations/pdf/Martin2006.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Hamed, Nagy. "Investigating the mechanisms underlying the pathogenesis of alopecia areata." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/20611/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Juhan, Nicole McKeown. "Molecular mechanisms of porcine circovirus 2 replication and pathogenesis." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/27329.

Full text

Abstract:

The non-pathogenic porcine circovirus type 1 (PCV1) was originally isolated as a persistent contaminant of the porcine kidney cell line PK-15. Whereas, porcine circovirus type 2 (PCV2) causes postweaning multisystemic wasting syndrome (PMWS) in pigs, which is devastating to the swine industry. My objectives were to determine the effect of maternally derived antibodies on PCV2 infection, assess the role of 2 amino acid substitutions in the PCV2 capsid protein in PCV2 attenuation, evaluate the effect of Rep gene exchange between PCV1 and PCV2 on growth characteristics of a chimeric PCV2, and e

APA, Harvard, Vancouver, ISO, and other styles

34

Azzopardi, Duncan. "Investigating the mechanisms of pathogenesis underlying inherited colorectal adenomatous polyposis." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55844/.

Full text

Abstract:

In order to investigate the role of nonsynonymous variants of the APC gene in inherited predisposition to colorectal adenomas (CRAs) the entire APC ORF was sequenced in 691 unrelated North American patients with CRAs and 969 healthy controls. There was significant over representation of rare inherited nonsynonymous variants in patients who did not carry conventional pathogenic mutations in APC or MUTYH (P = 0.0113) when compared to patients with familial adenomatous polyposis (FAP) and MUTYH associated polyposis (MAP). The over representation was highest in non-FAP non-MAP patients with 11 to

APA, Harvard, Vancouver, ISO, and other styles

35

Fiore, Vincent F. "INVESTIGATION OF MECHANOTRANSDUCTORY MECHANISMS IN THE PATHOGENESIS OF LUNG FIBROSIS." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53424.

Full text

Abstract:

Fibrosis of vital organs remains one of the leading causes of death in the developed world, where it occurs predominantly in soft tissues (liver, lung, kidney, heart) through fibroblast proliferation and deposition of extracellular matrix (ECM). In the process of fibrosis, remodeling and deposition of ECM results in stiffening of cellular microenvironment; cells also respond to these changes in the stiffness through engagement of their cytoskeleton and signaling via cell-ECM contacts. Thus, understanding to what extent the stiffness of the cellular microenvironment changes as a consequence o

APA, Harvard, Vancouver, ISO, and other styles

36

Pitzalis, Constantino. "Role of adhesion mechanisms in the pathogenesis of chronic synovitis." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307771.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Nunes, da Silva Ana Sofia. "Characterization of the molecular mechanisms involved in severe malaria pathogenesis." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC065.

Full text

Abstract:

L'importante virulence de P. Falciparum a été reliée à la capacité du parasite à adhérer aux cellules endothéliales de la microvasculature ou aux syncytiotrophoblastes placentaires. La séquestration de globules rouges infectés dans différents organes conduit à l'apparition des symptômes cliniques de la maladie. Les protéines variables PfEMP1, exprimées à la surface des hématies parasitées, sont les ligands parasitaires majeurs responsables de la cytoadhérence. PfEMP1-VAR2CSA est le candidat vaccinal le plus prometteur pour lutter contre le paludisme gestationnel. Afin de mieux caractériser les

APA, Harvard, Vancouver, ISO, and other styles

38

Roberts, Daniel Paul. "Molecular mechanisms of pathogenesis incited by Erwinia carotovora subsp. carotovora." Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/71251.

Full text

Abstract:

Erwinia carotovora subsp. Carotovora (Ecc) incites soft-rot on many plants. It is believed that soft-rot is due to the concerted activity of extracellular enzymes. Recombinant DNA techniques were used to study the molecular basis of pathogenesis incited by Ecc. Specifically, a clone library of Ecc strain EC14 DNA in plasmid pBR322 was constructed and transformed into Escherichia coli strain HB101. Some of the E. coli strains that contain these hybrid plasmids produce pectinases or cellulase(s). Plasmid pDR1 contains a 3.4 kilobase (kb) EC14 DNA fragment and mediates the production of endo-pect

APA, Harvard, Vancouver, ISO, and other styles

39

Elli, F. "MOLECULAR AND CELLULAR MECHANISMS OF VASCULAR CALCIFICATION: PATHOGENESIS AND TREATMENT." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/245812.

Full text

Abstract:

Vascular calciﬁcation is a signiﬁcant contributor to cardiovascular risk in chronic kidney disease (CKD) patients, and its extent and severity has been correlated with mortality in several studies. Hyperphosphatemia predisposes these patients to early and progressive vascular calcification: it appears to be involved in a number of mechanisms that trigger and promote the progression of this active and cell-mediated pathological process, in which vascular smooth muscle cells (VSMCs) residing in the tunica media of blood vessels are the main cell type actively involved. We developed an in vitro

APA, Harvard, Vancouver, ISO, and other styles

40

Whiteman, Ineka T. "Cytoskeletal proteins and early neurodegenerative mechanisms in Alzheimer's disease." Thesis, The University of Sydney, 2011. https://hdl.handle.net/2123/28860.

Full text

Abstract:

Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder that is histopathologically characterized by several hallmark lesions, including extracellular plaques comprised of amyloid beta (AB) peptides, neuropil threads and intra-neuronal neurofibrillary tangles, both of which are comprised of hyperphosphorylated microtubule-associated (MAP) protein tau. Neuropil threads are one of the earliest lesions observed in AD brain and the extent of their presence correlates with cognitive decline and disease progression. In addition, rod-like aggregates of actin and actin depolymerizing fact

APA, Harvard, Vancouver, ISO, and other styles

41

Sun, Xiulian. "Molecular mechanism of Alzheimer's disease pathogenesis in Down syndrome." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/31167.

Full text

Abstract:

Alzheimer's disease (AD) is the most common neurodegenerative disease leading to dementia. Neuritic plaques and neurofibrillary tangles are the two hallmarks of AD neuropathology. The molecular mechanism underlying AD pathogenesis remains unknown. It is believed that deposition of amyloid β (Aβ) protein in the brain plays a pivotal role in AD pathogenesis. Aβ, the central component of neuritic plaques, is derived from β-amyloid precursor protein (APP) by sequential cleavages by β- and γ-secretase. Nearly all individuals with Down Syndrome (DS) show characteristic AD pathological changes after

APA, Harvard, Vancouver, ISO, and other styles

42

Abdul, Rahim Roslina. "Molecular mechanism underlying the pathogenesis of NAFLD and NASH." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12074/.

Full text

Abstract:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor (PPAR)-γ agonist that improves peripheral insulin sensitivity and reduces hepatocellular injury/ inflammation in non-alcoholic steatohepatitis (NASH). However, the underlying hepatic mechanism of action is not clearly understood with PGZ treatment. Therefore, liver biopsies were used to study genes, protein and immunohistochemistry expression of hepatocyte and hepatic stellate cell markers. PGZ decreased both αSMA and PPAR β expression in stellate cell and PPAR α hepatocyte expression, hence inhibit both stellate cell activatio

APA, Harvard, Vancouver, ISO, and other styles

43

Duarte, Nádia. "Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes." Doctoral thesis, Umeå universitet, Medicinsk biovetenskap, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-601.

Full text

Abstract:

Type 1 diabetes is an autoimmune disorder determined both by genetic and environmental factors. The Non-obese diabetic (NOD) mouse is one of the best animal models of this disease. It spontaneously develops diabetes through a process resembling the human pathogenesis. The strong association of NOD Type 1 diabetes to the MHC region and the existence of other diabetes susceptibility loci are also in parallel with the human disease. The identity of the genetic factors and biological function mediated by these loci remain, however, largely unknown. Like in other autoimmune diseases, defects in tol

APA, Harvard, Vancouver, ISO, and other styles

44

Ressiniotis, Thomas. "Molecular mechanisms involved in the pathogenesis of primary open angle glaucoma." Thesis, University of Newcastle upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437247.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Wickenden, Julie Anne. "Pathogenesis of emphysema : molecular mechanisms underlying cigarette smoke-induced cell death." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/27662.

Full text

Abstract:

Emphysema is characterised by enlargement of the distal airspaces in the lungs due to destruction of alveolar walls, and was initially thought to be the result of matrix destruction from a protease-antiprotease and oxidant-antioxidant imbalance, leading to detachment of alveolar cells. however, recently apoptosis has been implicated in alveolar cell loss; increased numbers of apoptotic epithelial and endothelial cells have been observed in the lungs of emphysema patients. Thus the effect of cigarette smoke on apoptotic cell death was investigated. Unexpectedly, cigarette smoke condensate (CSC)

APA, Harvard, Vancouver, ISO, and other styles

46

Duarte, Nadia. "Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes /." Umeå : Medical Biosciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-601.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Delbianco, Alice. "Molecular mechanisms involved in the pathogenesis of beet soil-borne viruses." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01017177.

Full text

Abstract:

The genus Benyvirus includes the most important and widespread sugar beet viruses transmitted through the soil by the plasmodiophorid Polymyxa betae. In particular Beet necrotic yellow vein virus (BNYVV), the leading infectious agent that affects sugar beet, causes an abnormal rootlet proliferation known as rhizomania. Beet soil-borne mosaic virus (BSBMV) is widely distributed in the United States and, up to date has not been reported in others countries. My PhD project aims to investigate molecular interactions between BNYVV and BSBMV and the mechanisms involved in the pathogenesis of these v

APA, Harvard, Vancouver, ISO, and other styles

48

Myrillas, Theofilos T. "Cellular mechanisms underlying the pathogenesis of cyclosporin A-induced gingival overgrowth." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284391.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Delbianco, Alice <1981&gt. "Molecular mechanisms involved in the pathogenesis of beet soil-borne viruses." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5353/1/delbianco_alice_tesi.pdf.

Full text

Abstract:

The genus Benyvirus includes the most important and widespread sugar beet viruses transmitted through the soil by the plasmodiophorid Polymyxa betae. In particular Beet necrotic yellow vein virus (BNYVV), the leading infectious agent that affects sugar beet, causes an abnormal rootlet proliferation known as rhizomania. Beet soil-borne mosaic virus (BSBMV) is widely distributed in the United States and, up to date has not been reported in others countries. My PhD project aims to investigate molecular interactions between BNYVV and BSBMV and the mechanisms involved in the pathogenesis of these

APA, Harvard, Vancouver, ISO, and other styles

50

Delbianco, Alice <1981&gt. "Molecular mechanisms involved in the pathogenesis of beet soil-borne viruses." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5353/.

Full text

Abstract:

The genus Benyvirus includes the most important and widespread sugar beet viruses transmitted through the soil by the plasmodiophorid Polymyxa betae. In particular Beet necrotic yellow vein virus (BNYVV), the leading infectious agent that affects sugar beet, causes an abnormal rootlet proliferation known as rhizomania. Beet soil-borne mosaic virus (BSBMV) is widely distributed in the United States and, up to date has not been reported in others countries. My PhD project aims to investigate molecular interactions between BNYVV and BSBMV and the mechanisms involved in the pathogenesis of these

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!