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1

Maetzel, Andreas. Economic assessment: Celecoxib and rofecoxib for patients with osteoarthritis or rheumatoid arthritis. Canadian Coordinating Office for Health Technology Assessment, 2002.

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2

Maetzel, Andreas. The cost-effectiveness of celecoxib and rofecoxib in patients with osteoarthritis or rheumatoid arthritis. Canadian Coordinating Office for Health Technology Assessment, 2002.

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3

Rosenstein, Ann A. Water exercises for osteoarthritis: The effective way to reduce pain and stiffness, while increasing endurance and strength. Idyll Arbor, 2007.

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4

Joanne, Lord, and National Co-ordinating Centre for HTA (Great Britain), eds. Economic evaluation of a primary care-based education programme for patients with osteoarthritis of the knee. Core Research on behalf of the NCCHTA, 1999.

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5

Parker, James N., and Philip M. Parker. The official patient's sourcebook on osteoarthritis. ICON Group International, 2003.

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6

Grawe, Brian M., J. Gabriel Horneff III, and Joseph A. Abboud, eds. Glenohumeral Osteoarthritis in the Young Patient. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-91190-4.

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7

Hunder, Gene G. Guide to managing arthritis. Mayo Clinic, 2006.

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8

Parker, David, ed. Management of Knee Osteoarthritis in the Younger, Active Patient. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48530-9.

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9

Living with Osteoarthritis. Sheldon Press, 2003.

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10

Muscle rehabilitation of patients with osteoarthritis of the knees. 1992.

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11

Muscle rehabilitation of patients with osteoarthritis of the knees. 1991.

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12

Muscle rehabilitation of patients with osteoarthritis of the knees. 1991.

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13

Kloppenburg, Margreet. Clinical assessment: signs, symptoms, and patient perceptions in osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0015.

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Osteoarthritis (OA) is a disorder that can affect any joint. It results in a high clinical burden in many patients. Patients with OA experience a wide range of symptoms and clinical signs such as pain, disability, stiffness, tenderness, crepitus, and decreased mobility and strength in their osteoarthritic joints, where the impact depends on the involved joint. Also general symptoms such as fatigue and psychosocial consequences are experienced by OA patients. The impact of symptoms and signs does not only depend on osteoarthritic abnormalities, but also on patient factors, such as coping strate
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14

Lane, Nancy E., and Daniel J. Wallace. All About Osteoarthritis: The Definitive Resource for Arthritis Patients and Their Families. Oxford University Press, USA, 2002.

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15

Wallace, Daniel J. All about Osteoarthritis: The Definitive Resource for Arthritis Patients and Their Families. Oxford University Press, 2002.

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16

Hawker, Gillian, Anne Lyddiatt, Linda Li, et al. Patient information strategies for decision-making and management of osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0021.

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Osteoarthritis (OA) is a chronic, disabling disease that warrants care that aligns with the principles of ‘chronic disease management’. Central to the success of chronic disease management is the ‘informed, activated patient’. Patient information strategies, including the use of patient decision aids, are essential to enabling patients with OA to self-manage their disease and engage in informed, shared decision-making. Such strategies are best delivered by a multidisciplinary team of healthcare providers and adapted to the characteristics, preferences, and values of the individual OA patient.
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17

Shahane, Shantanu. Osteoarthritis of the elbow joint. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.005.005.

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♦ Symptomatic, primary osteoarthritis of the elbow usually occurs in young men involved in heavy manual labour.♦ Common causes of secondary osteoarthritis of the elbow are trauma, infection, bleeding disorders and neuropathic conditions.♦ Clinically, the commonest presenting symptom is loss of motion. Patients can also complain of pain, locking and ulnar nerve symptoms.♦ Plain X-rays are usually sufficient for diagnosis. They show reduction in joint space and osteophytes at the tip of olecranon and coronoid processes. Loose bodies are also frequently seen.♦ Symptoms in early stages of arthriti
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18

Sawitzke, Allen D., and Daniel O. Clegg. Supplements for the treatment of osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0031.

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Foodstuffs have long been thought to affect health beyond just their supply of calories. Some have been used as a ‘dietary supplement’ to health and thereby aid patients with osteoarthritis. The evidence demonstrating the effectiveness of using dietary supplements to improve pain or protect the structure of the joint is not complete, but some preliminary conclusions are possible. This chapter is an inclusive review of the current published evidence for selected commonly recommended dietary supplements for the treatment of osteoarthritis. Among the dietary supplements, the most credible evidenc
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19

Grassi, Walter, Tadashi Okano, and Emilio Filippucci. Ultrasound in osteoarthritis and crystal-related arthropathies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0017.

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Ultrasonography (US) is a safe and cheap imaging technique which in experienced hands allows for a multiplanar and multisite high-resolution assessment of both morphological and structural features of bone, cartilage, and intra- or periarticular soft tissues. This chapter describes the main applications of US in patients with osteoarthritis (OA) and crystal-related arthropathies. Imaging plays a key role for diagnosis, prognosis, and follow-up in patients with OA. Although conventional radiography is still the gold standard imaging technique in daily clinical practice, US has been revealed to
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20

Thorlund, Jonas Bloch, and L. Stefan Lohmander. Other surgical approaches in the management of osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0034.

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Joint replacement is often considered the surgical treatment for patients with osteoarthritis (OA). However, several other surgical treatments, of which some are more frequently performed, have been advocated for patients with OA in order to relieve symptoms, stall progression, and avoid or postpone joint replacement. This chapter briefly describes the most common procedures such as knee and hip arthroscopy and knee and hip osteotomy. It also reviews the evidence for the efficacy of these treatments compared with non-surgical alternatives, which is frequently insufficient due to lack of contro
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21

Pathania, Ms Shivangi. Psychometric Properties of the Tinetti Performance Oriented Mobility Assessment (POMA) Scale in Patients with Knee Osteoarthritis. Independently Published, 2018.

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22

McDougall, Jason J., and Joel A. Vilensky. The innervation of the joint and its role in osteoarthritis pain. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0007.

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Diarthrodial joints possess an extensive network of sensory and sympathetic nerve fibres whose physiological functions are varied and complex. Nerves are primarily located in the synovium but also innervate the subchondral bone, the outer third of menisci, and the superficial surface of tendons and ligaments. Large-diameter, myelinated neurons are involved in joint position sense while small-diameter neurons with thin or no myelin typically sense pain. The small-diameter nerves in conjunction with sympathetic fibres control synovial blood flow and maintain joint homeostasis. In patients with o
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23

Dekker, Joost, Daniel Bossen, Jasmijn Holla, Mariëtte de Rooij, Cindy Veenhof, and Marike van der Leeden. Psychological strategies in osteoarthritis of the knee or hip. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0025.

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Characteristic clinical presentations of osteoarthritis (OA) include pain and activity limitations. These presentations are dependent on psychological processes. The literature reviewed in this chapter leads to the following conclusions: (1) symptoms of depression, anxiety, and fatigue are more prevalent among patients with OA than among the general population. Recently, a depressive mood phenotype has been identified in knee OA. (2) Symptoms of depression, anxiety, and fatigue, as well as other psychological variables are established risk factors for future worsening of pain and activity limi
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24

Henriksen, Marius, Robin Christensen, Berit L. Heitmann, and Henning Bliddal. Weight loss. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0023.

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Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis. Loss of at least 10% of body weight is recognized as a cornerstone in the management of obese patients with osteoarthritis, and can lead to significant improvement in symptoms, pain relief, physical function, and health-related quality of life. However, questions still remain surrounding optimal management and whether structural disease progression can be arrested. Given the significant health, social, and economic burden of osteoarthritis, especially in obese patients, it is imperative to
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25

Javaid, Kassim, and Paul Wordsworth. Osteoarthritis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.010007.

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♦ Osteoarthritis is the outcome of many different disease processes♦ Correlation between radiographic appearance and symptoms is poor♦ Prevalence increases rapidly with age♦ A multidimensional approach in treatment should include patient education, physical therapy, analgesia, and ergonomic assessment♦ Surgical approaches to treatment should adopt a holistic approach.
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26

Simon, Lee S., and Marc C. Hochberg. Non-steroidal anti-inflammatory drugs. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0030.

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Non-steroidal anti-inflammatory drugs (NSAIDs) are a chemically diverse group of compounds that share three cardinal characteristics: they are anti-inflammatory, analgesic, and antipyretic. They are approved by regulatory authorities for the treatment of patients with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gout, and some forms of juvenile idiopathic arthritis. There are at least 20 chemically different NSAIDs currently available in Europe and the United States. These include not only the ‘traditional’ non-selective cyclooxygenase (COX) inhibitors that inhibit both
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27

Pandit, Hemant, Christopher Dodd, and David Murray. Unicompartmental knee replacement. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199550647.003.008013.

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♦ Ideal treatment option for end-stage osteoarthritis affecting a single compartment of the knee♦ Unicompartmental knee replacement has many advantages over total knee replacement• Restores near normal kinematics• Usually gives a better range of movement• Patients require a shorter hospital stay• Fewer serious complications
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28

Lafeber, Floris P. J. G., Nick J. Besselink, and Simon C. Mastbergen. Synovium and capsule. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0006.

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Synovium is an integrated tissue of the diarthrodial joints that interacts with all the other joint tissues and specifically is important in nourishment and lubrication of the articular cartilage, removal of waste products, and immunological surveillance. Chronic as well as recurrent low-grade synovial inflammation definitely contributes to progression and symptoms of certain patients with osteoarthritis. Low-grade inflammation may even be causative in the disease. The challenge is that osteoarthritis is a heterogeneous disorder with inflammation not only of the synovial tissue but with its me
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29

Abboud, Joseph, Brian M. Grawe, and J. Gabriel Horneff III. Glenohumeral Osteoarthritis in the Young Patient: Evaluation and Management. Springer International Publishing AG, 2022.

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30

Glenohumeral Osteoarthritis in the Young Patient: Evaluation and Management. Springer International Publishing AG, 2023.

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31

Manek, Nisha J., and George Muñoz. Common Rheumatic Diseases in the Elderly. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190466268.003.0022.

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With increasing longevity, the prevalence and impact of rheumatic diseases are projected to rise dramatically in the coming decades. Common rheumatic diseases such as osteoarthritis typically arise among the elderly. For diseases such as rheumatoid arthritis and gout, patients diagnosed at earlier ages carry the burden into their later years. Gout is associated both with comorbid conditions whose prevalence rises with age as well as with medications commonly prescribed in older people. These factors, along with the unique challenges associated with optimal diagnosis and treatment of arthritide
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32

The economic burden of osteoarthritis in Ontario: The patient's perspective. National Library of Canada, 2003.

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33

MD, Brian Kotzin, and Herbert Kaplan MD. Patient Education Booklets: What You Should Know About Arthritic Disorders: Osteoarthritis (Patient Education Booklets). Mosby International, 1992.

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34

Abhishek, Abhishek, and Michael Doherty. Clinical features of calcium pyrophosphate crystal deposition. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0050.

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Calcium pyrophosphate deposition (CPPD) occurs in the elderly, and is commonly asymptomatic. However, it can cause acute calcium pyrophosphate (CPP) crystal arthritis, chronic CPP crystal inflammatory arthritis, and is frequently present in joints with osteoarthritis (OA). Acute CPP crystal arthritis presents with rapid onset of acute synovitis, which frequently affects the knees, wrists, shoulders, and elbows. It can mimic sepsis in the elderly, and may require hospital admission. Patients with CPPD plus OA may have more inflammatory signs and symptoms (e.g. joint swelling, stiffness) than th
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35

de Vlam, Kurt. Overview of psoriatic arthritis pathogenesis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0004.

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Psoriatic arthritis (PsA) is a chronic inflammatory arthritis occurring in patients with psoriasis. Some consider it as part of the heterogeneous group of diseases unified in the concept of spondyloarthritis (SpA). At least some subtypes, such as the oligoarticular and axial subtypes, can be classified as SpA. The aetiology and pathogenesis are poorly understood. An enthesitis-based model was proposed to unify skin and joint manifestation and to differentiate PsA from other rheumatic diseases such as rheumatoid arthritis and osteoarthritis. The development of PsA results from the interplay of
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36

Publications, ICON Health. The Official Patient's Sourcebook on Osteoarthritis: Directory for the Internet Age. Icon Health Publications, 2003.

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37

Doherty, Michael, David J. Hunter, Hans Bijlsma, Nigel Arden, and Nicola Dalbeth, eds. Oxford Textbook of Osteoarthritis and Crystal Arthropathy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.001.0001.

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The Oxford Textbook of Osteoarthritis and Crystal Arthropathy provides full coverage of joint failure, and includes detailed sections on epidemiology, risk factors, clinical assessment, and investigations. There are also new in-depth sections on gout and other crystal arthropathies. Clinically relevant and easily understandable overviews of basic science, including pathology and pain physiology, along with critical appraisal of current guidelines, make this a highly valuable resource. Significant coverage is also given to patient education and the involvement of the patient in management plann
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38

Arden, Nigel, and Michael C. Nevitt. Epidemiology. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0008.

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Despite the impact of osteoarthritis (OA) on patients and the health service, OA remains an elusive condition to define and treat. Traditionally, OA has been diagnosed using radiographs and more recently magnetic resonance imaging; however, the last 20 years of research have changed our thinking about the disease and its treatment. We know today that OA takes up to 10–15 years to develop, has a range of risk factors, and that there is a considerable discordance between symptoms and structural signs, such that new classifications and definitions are moving away from structural criteria to combi
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39

Practicalities of using TENS for specific conditions and situations. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199673278.003.0007.

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Research studies have failed to evaluate different TENS techniques for specific conditions. Safe and appropriate TENS technique is based on the use of conventional TENS delivered at a strong, non-painful intensity at the site of pain in the first instance with patients selecting pulse pattern, frequency, and duration for reasons of comfort. In practice, it is necessary to adapt this approach for specific painful conditions. The purpose of this chapter is to demonstrate how the general principles of good practice are applied when using TENS to manage various painful conditions. The chapter disc
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40

Clinical research on the efficacy of TENS. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199673278.003.0008.

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The acceptance of a treatment into mainstream medicine is influenced by a wide variety of factors. Traditionally, practitioners rely on information gleaned from their experience of using treatments on their patients although this can be misleading. Clinical research uses experiments to determine whether therapeutic effects of a treatment are attributed to its active ingredient by removing biases that confound clinical observation. This helps to determine whether treatments are efficacious. The purpose of this chapter is to overview evidence from clinical research on the efficacy of TENS for th
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41

Bennell, Kim L., Ans Van Ginckel, Fiona Dobson, and Rana S. Hinman. Exercise for the person with osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0022.

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Because of its beneficial effects on pain and physical dysfunction commonly reported by afflicted individuals, all clinical guidelines of osteoarthritis (OA) advocate exercise therapy as a vital component of conservative management strategies. Although the optimal exercise modalities in terms of dosage, exercise type, or delivery mode are not yet known, clinical benefits can be achieved with a wide range of exercise types. While treatment effect sizes may be considered small to moderate, they are similar to those of common analgesic drugs or oral non-steroidal anti-inflammatories but seem to e
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42

Bannwarth, Bernard, and Francis Berenbaum. Systemic analgesics (including paracetamol and opioids). Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0029.

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Apart from non-steroidal anti-inflammatory drugs (NSAIDs), there are only two categories of systemic analgesics, namely paracetamol (acetaminophen) and opioids, that are currently available worldwide for clinical use. Paracetamol is poorly effective in relieving pain and improving function in patients with symptomatic osteoarthritis (OA). Furthermore, its safety profile is less favourable than classically thought. In fact, there is evidence paracetamol acts as a weak inhibitor of the cyclooxygenase enzymes. Given that paracetamol poses a lower risk of severe adverse events than NSAIDs while be
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43

Abhishek, Abhishek, and Michael Doherty. Placebo, nocebo, and contextual effects. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0027.

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Placebo effect is an example of ‘contextual’ effect and is the symptomatic improvement experienced by patients who have unknowingly received a placebo (inactive treatment) instead of an active drug. It occurs due to patient-specific factors such as expectation of improvement and is influenced by the context in which the treatment is delivered. Nocebo effect is the opposite of placebo effect and includes worsening of symptoms or incident adverse effects due to expectancy or negative contextual or practitioner influence. Placebo effect has been demonstrated in a range of musculoskeletal conditio
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44

Holden, Melanie A., Martin J. Thomas, and Krysia S. Dziedzic. Miscellaneous physical therapies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0026.

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Miscellaneous physical therapies, such as assistive devices, thermotherapy, manual therapy, and electrotherapy are commonly used to treat patients with osteoarthritis (OA) in addition to written information and exercise. However, the evidence underpinning specific miscellaneous physical therapies is often limited, with small study sizes, heterogeneous populations, and differing study designs making it difficult to draw firm conclusions about their effectiveness. One or more miscellaneous physical therapies feature within 15 current clinical guidelines for OA. The specific types of physical the
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45

Rowbotham, Emma L., and Andrew J. Grainger. Radiographic imaging. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0066.

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Plain film radiography is often the first imaging modality employed in the assessment of patients with a rheumatological condition. More recently this has been superseded by cross-sectional imaging, in particular ultrasound and MRI, which have improved sensitivity in detection of early disease when compared with plain film imaging. However, there remains a role for conventional radiography in both the initial diagnosis and monitoring of disease progression. A standard approach to assessing radiographs in the context of arthropathy is usually employed by radiologists; by following this structur
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46

Rowbotham, Emma L., and Andrew J. Grainger. Radiographic imaging. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199642489.003.0066_update_001.

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Plain film radiography is often the first imaging modality employed in the assessment of patients with a rheumatological condition. More recently this has been superseded by cross-sectional imaging, in particular ultrasound and MRI, which have improved sensitivity in detection of early disease when compared with plain film imaging. However, there remains a role for conventional radiography in both the initial diagnosis and monitoring of disease progression. A standard approach to assessing radiographs in the context of arthropathy is usually employed by radiologists; by following this structur
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47

MD, Brian Kotzin, and Herbert Kaplan MD. Patient Education Booklets: What You Should Know About Arthritic Disorders: Osteoarthritis/rheumatoid Arthritus/systemic Lupus Erythematosis (Patient Education Booklets). Mosby International, 1992.

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48

Newell-Price, John, Alia Munir, and Miguel Debono. Obesity: differential diagnosis. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0081.

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This topic addresses the causes and consequences of obesity, defined as a body mass index (BMI) of 30 or above. While BMI is the most commonly used measure of obesity, the waist-to-height ratio correlates better with visceral obesity. At least 1.1 billion adults are overweight worldwide, but a medical cause for obesity is found in less than 1 out of every 100 cases. The health consequences of obesity are diverse and serious. Approximately 50% of all hypertension is secondary to obesity, and the heart may also be harmed by obesity-induced chronic volume overload and ischaemic heart disease. Obe
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49

Arden, Nigel, and Terence O’Neill. Intra-articular injection therapy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0032.

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Intra-articular injection therapy is widely used in the management of osteoarthritis (OA). It has advantages over oral therapy in that it can provide targeted therapy to individual joint sites and at higher dose than could be achieved through oral administration and with fewer adverse effects. Intra-articular steroid therapy, the most widely used intra-articular therapy, is safe and effective in the short term particularly at the knee; though more studies are needed to better characterize the longer-term benefit. The role of intra-articular hyaluronic acid in clinical management of OA is less
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50

Merkesdal, Sonja, and Wilfried Mau. Health economics. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0031.

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The economic burden of rheumatic diseases for society, various payers, and last but not least the individual patient has been increasingly recognized. In addition to the well-known impact of back pain and osteoarthritis, the upcoming new and expensive therapies have made this issue especially intriguing in the treatment of rheumatoid arthritis (RA). A mean international estimate of the total annual costs of RA, mainly consisting of direct resource consumption and indirect costs due to productivity losses relating to paid work, comes to about €5600. Other inflammatory rheumatologic diseases (an
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