Relevant bibliographies by topics / PBR28

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'PBR28'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "PBR28"

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Owen, David R., Owain W. Howell, Sac-Pham Tang, et al. "Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation." Journal of Cerebral Blood Flow & Metabolism 30, no. 9 (2010): 1608–18. http://dx.doi.org/10.1038/jcbfm.2010.63.

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[11C]PBR28, a radioligand targeting the translocator protein (TSPO), does not produce a specific binding signal in approximately 14% of healthy volunteers. This phenomenon has not been reported for [11C]PK11195, another TSPO radioligand. We measured the specific binding signals with [3H]PK11195 and [3H]PBR28 in brain tissue from 22 donors. Overall, 23% of the samples did not generate a visually detectable specific autoradiographic signal with [3H]PBR28, although all samples showed [3H]PK11195 binding. There was a marked reduction in the affinity of [3H]PBR28 for TSPO in samples with no visible
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Datta, Gourab, Ines R. Violante, Gregory Scott, et al. "Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis." Multiple Sclerosis Journal 23, no. 11 (2016): 1469–78. http://dx.doi.org/10.1177/1352458516681504.

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Background: Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this. Objective: To explore the in vivo relationships between MRS and PET [11C]PBR28 in MS over a range of brain inflammatory burden. Methods: A total of 23 patients were studied. TSPO PET imaging with [11C]PBR28, single voxel MRS and conventional magnetic resonance imaging (MRI) sequences were undertaken. Disability
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Herranz, Elena, Céline Louapre, Constantina Andrada Treaba, et al. "Profiles of cortical inflammation in multiple sclerosis by 11C-PBR28 MR-PET and 7 Tesla imaging." Multiple Sclerosis Journal 26, no. 12 (2019): 1497–509. http://dx.doi.org/10.1177/1352458519867320.

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Background: Neuroinflammation with microglia activation is thought to be closely related to cortical multiple sclerosis (MS) lesion pathogenesis. Objective: Using 11C-PBR28 and 7 Tesla (7T) imaging, we assessed in 9 relapsing–remitting multiple sclerosis (RRMS) and 10 secondary progressive multiple sclerosis (SPMS) patients the following: (1) microglia activation in lesioned and normal-appearing cortex, (2) cortical lesion inflammatory profiles, and (3) the relationship between neuroinflammation and cortical integrity. Methods: Mean 11C-PBR28 uptake was measured in focal cortical lesions, cort
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Owen, David R., Astrid J. Yeo, Roger N. Gunn, et al. "An 18-kDa Translocator Protein (TSPO) Polymorphism Explains Differences in Binding Affinity of the PET Radioligand PBR28." Journal of Cerebral Blood Flow & Metabolism 32, no. 1 (2011): 1–5. http://dx.doi.org/10.1038/jcbfm.2011.147.

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[11C]PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of signal are confounded by large interindividual variability in binding affinity, which displays a trimodal distribution compatible with a codominant genetic trait. Here, we tested directly for an underlying genetic mechanism to explain this. Binding affinity of PBR28 was measured in platelets isolated from 41 human subjects and tested for association with polymorphisms in TSPO and genes encoding other proteins in the
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Kreisl, William C., Kimberly J. Jenko, Christina S. Hines, et al. "A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of Neuroinflammation." Journal of Cerebral Blood Flow & Metabolism 33, no. 1 (2012): 53–58. http://dx.doi.org/10.1038/jcbfm.2012.131.

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Second-generation radioligands for translocator protein (TSPO), an inflammation marker, are confounded by the codominant rs6971 polymorphism that affects binding affinity. The resulting three groups are homozygous for high-affinity state (HH), homozygous for low-affinity state (LL), or heterozygous (HL). We tested if in vitro binding to leukocytes distinguished TSPO genotypes and if genotype could affect clinical studies using the TSPO radioligand [11C]PBR28. In vitro binding to leukocytes and [11C]PBR28 brain imaging were performed in 27 human subjects with known TSPO genotype. Specific [3H]P
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Toppala, Sini, Laura L. Ekblad, Jouni Tuisku та ін. "Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia". Neurology 96, № 12 (2021): e1608-e1619. http://dx.doi.org/10.1212/wnl.0000000000011612.

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ObjectiveTo examine whether early β–amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia.MethodsWe examined 54 volunteers (mean age 70.0 years, 56% women, 51% APOE ɛ4 carriers) with the translocator protein (TSPO) tracer [11C]PBR28 to assess neuroinflammation and with [11C] Pittsburgh compound B (PiB) to assess cerebral Aβ accumulation. [11C]PBR28 and [11C]PiB standardized uptake value ratios (SUVRs) were quantified in 6 regions of interests by using the cerebellar cortex as a pseudo-reference and reference region, r
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Auriemma, Renato, Mattia Sponchioni, Umberto Capasso Palmiero, et al. "Synthesis and Characterization of a “Clickable” PBR28 TSPO-Selective Ligand Derivative Suitable for the Functionalization of Biodegradable Polymer Nanoparticles." Nanomaterials 11, no. 7 (2021): 1693. http://dx.doi.org/10.3390/nano11071693.

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Reactive microgliosis is a pathological hallmark that accompanies neuronal demise in many neurodegenerative diseases, ranging from acute brain/spinal cord injuries to chronic diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and age-related dementia. One strategy to assess and monitor microgliosis is to use positron emission tomography (PET) by exploiting radioligands selective for the 18 kDa translocator protein (TSPO) which is highly upregulated in the brain in pathological conditions. Several TSPO ligands have been developed and validated, so far. Among these,
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Sandiego, Christine M., Jean-Dominique Gallezot, Brian Pittman, et al. "Imaging robust microglial activation after lipopolysaccharide administration in humans with PET." Proceedings of the National Academy of Sciences 112, no. 40 (2015): 12468–73. http://dx.doi.org/10.1073/pnas.1511003112.

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Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric diseases. The core process in neuroinflammation is activation of microglia, the innate immune cells of the brain. We measured the neuroinflammatory response produced by a systemic administration of the Escherichia coli lipopolysaccharide (LPS; also called endotoxin) in humans with the positron emission tomography (PET) radiotracer [11C]PBR28, which binds to translocator protein, a molecular marker that is up-regulated by microglial activation. In addition, inflammatory cytokines in serum and sickness beh
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Sari, Hasan, Riccardo Galbusera, Guillaume Bonnier, et al. "Multimodal Investigation of Neuroinflammation in Aviremic Patients With HIV on Antiretroviral Therapy and HIV Elite Controllers." Neurology - Neuroimmunology Neuroinflammation 9, no. 2 (2022): e1144. http://dx.doi.org/10.1212/nxi.0000000000001144.

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Background and ObjectivesThe presence of HIV in the CNS has been related to chronic immune activation and cognitive dysfunction. The aim of this work was to investigate (1) the presence of neuroinflammation in aviremic people with HIV (PWH) on therapy and in nontreated aviremic PWH (elite controllers [ECs]) using a translocator protein 18 kDa radioligand; (2) the relationship between neuroinflammation and cognitive function in aviremic PWH; and (3) the relationship between [11C]-PBR28 signal and quantitative MRI (qMRI) measures of brain tissue integrity such as T1 and T2 relaxation times (rts)
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Femminella, Grazia Daniela, Melanie Dani, Melanie Wood, et al. "Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume." Neurology 92, no. 12 (2019): e1331-e1343. http://dx.doi.org/10.1212/wnl.0000000000007133.

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ObjectiveTo investigate the influence of microglial activation in the early stages of Alzheimer's disease trajectory, we assessed the relationship between microglial activation and gray matter volume and hippocampal volume in patients with mild cognitive impairment (MCI).MethodsIn this study, 55 participants (37 with early stages of MCI and 18 controls) underwent [11C]PBR28 PET, a marker of microglial activation; volumetric MRI to evaluate gray matter and hippocampal volumes as well as clinical and neuropsychometric evaluation. [11C]PBR28 VT(volume of distribution) was calculated using arteria
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Dissertations / Theses on the topic "PBR28"

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Reis, Bernardo Sgarbi Chaves. "Estudo bioquímicos e imunológicos das proteínas Pb28 e Pb 27r do fungo Paracoccidioídes brasiliensis." Universidade Federal de Minas Gerais, 2007. http://hdl.handle.net/1843/CMFC-78PLFL.

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Aparacoccidioidomicose (PCM) é uma doença sistêmica, granulomatosa e endêmica da América Latina, cujo agente etiológico éo fungo Paracoccidioides brasiliensis. O diagnóstico da infecção é,principalmente, realizado por biópsia do tecido acometido. Diversos pesquisadores têm voltado sues esforços na tentativa de isolar antígenos capazes de diagnosticar, sorologicamente, pacientes comPCM, assimcomo desencadear uma resposta protetora à infecção. Oantígeno Mexo,obtido a partir da P. brasiliensis foicapaz de extração das proteínas extracelulares do fungo discriminar pacientes comPCM de indivíduos nã
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BARLETTA, VALERIA TERESA. "In vivo analyses of the correlates of cortical and white matter pathology in patients with multiple sclerosis by quantitative 7 Tesla and 3 Tesla MRI and molecular imaging." Doctoral thesis, 2021. http://hdl.handle.net/11573/1546445.

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This thesis is divided in two sections. The first reports the results from a project regarding the application of ultra-high-field quantitative MRI for the study of cortical grey matter pathology in patients with early multiple sclerosis (MS). Applying a Combined Myelin Estimation method, obtained by 7 Tesla magnetic resonance imaging, we aimed at characterizing cortical microstructural abnormalities related to myelin content in cortical lesions and normal-appearing cortex, to assess their evolution at 1-year follow-up and to relate cortical myelin changes to clinical and radiological disease
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Book chapters on the topic "PBR28"

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Donat, Cornelius K., Nazanin Mirzaei, Sac-Pham Tang, Paul Edison, and Magdalena Sastre. "Imaging of Microglial Activation in Alzheimer’s Disease by [11C]PBR28 PET." In Biomarkers for Alzheimer’s Disease Drug Development. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7704-8_22.

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Donat, Cornelius K., Nazanin Mirzaei, Sac-Pham Tang, Paul Edison, and Magdalena Sastre. "Erratum to: Imaging of Microglial Activation in Alzheimer’s Disease by [11C]PBR28 PET." In Biomarkers for Alzheimer’s Disease Drug Development. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7704-8_26.

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Zheng, Qi-Huang, Min Wang, and Bruce H. Mock. "Synthesis ofN-(2-[11C]Methoxybenzyl)-N-(4-Phenoxypyridin-3-yl)Acetamide ([11C]PBR28)." In Radiochemical Syntheses. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118140345.ch30.

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Kim, Sungeun, Kwangsik Nho, Shannon L. Risacher, et al. "PARP1 Gene Variation and Microglial Activity on [11C]PBR28 PET in Older Adults at Risk for Alzheimer’s Disease." In Multimodal Brain Image Analysis. Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-02126-3_15.

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Bevilacqua, Vitoantonio, Paolo Pannarale, Giuseppe Mastronardi, et al. "High-Throughput Analysis of the Drug Mode of Action of PB28, MC18 and MC70, Three Cyclohexylpiperazine Derivative New Molecules." In Advanced Intelligent Computing Theories and Applications. With Aspects of Artificial Intelligence. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-85984-0_130.

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Conference papers on the topic "PBR28"

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Mabrouk, Rostom. "A Model to Explain 11C-PBR28 SUV Profile in Parkinson’s disease and Unaffected Lrrk2 Mutation Carriers." In 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE, 2017. http://dx.doi.org/10.1109/nssmic.2017.8533118.

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Whitehead, A. C., L. Brusaferri, L. Maccioni, et al. "A Bayesian Neural Network-Based Method For The Extraction Of A Metabolite Corrected Arterial Input Function From Dynamic [11C]PBR28 PET." In 2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD). IEEE, 2023. http://dx.doi.org/10.1109/nssmicrtsd49126.2023.10338687.

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Mosca, Michele, and Phillip Kaye. "Quantum Networks for Generating Arbitrary Quantum States." In International Conference on Quantum Information. OSA, 2001. http://dx.doi.org/10.1364/icqi.2001.pb28.

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