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Dissertations / Theses on the topic 'PDIA6'

Author: Grafiati

Published: 10 March 2023

Last updated: 19 July 2025

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1

Tufo, Grégory. "Recherche de nouveaux biomarqueurs de la résistance au cisplatine dans le cancer du poumon : rôle anti-apoptotique des PDIA4 et PDIA6." Versailles-St Quentin en Yvelines, 2012. http://www.theses.fr/2012VERS0017.

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Environ 80% des cancers du poumon sont des carcinomes du poumon non à petites cellules (NSCLC). Les NSCLC posent un enjeu médical majeur en raison de leur forte incidence et du taux de mortalité qu’ils induisent. Ils sont généralement traités avec le cisplatine (CDDP), l'un des agents anticancéreux les plus largement utilisés aujourd'hui. Cependant, après plusieurs mois, des cellules cancéreuses résistantes à l'apoptose induite par le CDDP apparaissent et compromettent le succès de la chimiothérapie. Le CDDP est un composé pro-apoptotique qui se lie l'ADN nucléaire pour former des liaisons int

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2

Eletto, Daniela. "Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response." Doctoral thesis, Universita degli studi di Salerno, 2012. http://hdl.handle.net/10556/1309.

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2010 - 2011<br>Mapping of the interaction between STAT1 and flavonoids Abstract An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and protein conformational changes induced by ligand binding. The methodology utilizes a combination of multiple technical approaches: limited proteolysis, MALDI TOF MS, circular dichroism and Surface Plasmon Resonance (SPR) to determine the binding sites in signal transducer and activator of transcription 1, STAT1 (87kDa)-flavonoid (Epigallocatechin-3-gallate, Myri

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3

Bastos, Sara. "Structural studies of protein Disulfide Isomerases: PDIA1 and PDILT." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114530.

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AbstractProtein disulfide isomerases (PDIs) family members are essential for proper folding of proteins entering the secretory pathway. Studies of these remarkable enzymes have shown that PDIs catalyze the oxidation, reduction and isomeration of disulfide bonds in the endoplasmic reticulum (ER). PDIs are found and conserved in a wide range of species and are ubiquitously expressed.In all eukaryotes, the ER redox potential must be tightly controlled since a large fraction of proteins within the cell require disulfide-bond formation. How PDIA1 maintains a balance between oxidation and reduction

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4

Chen, Jiaxuan. "The role of Pdia3 in vitamin D signaling in osteoblasts." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/50147.

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1a,25-Dihydroxyvitamin D3 (1a,25(OH)2D3) is a major functional metabolic form of vitamin D. 1a,25(OH)2D3 has drawn increasing attention due to its functions in addition to maintaining calcium phosphate homeostasis. It directly regulates mineralization by osteoblasts, matrix production and remodeling by chondrocytes, and contraction of cardiomyocytes. 1a,25(OH)2D3 and its analogues have shown beneficial effects in treating multiple sclerosis, diabetes and various types of cancer. In order to maximize the pharmaceutical potential of 1a,25(OH)2D3, a better understanding its cell signaling pathway

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5

Silva, Thaís Larissa Araujo de Oliveira. "Estudo da rota de externalização da dissulfeto isomerase protéica (PDIA1) em células endoteliais." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-09112015-113347/.

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Dissulfeto isomerase protéica (PDIA1 ou PDI) é uma chaperona e ditiol-dissulfeto oxido-redutase residente do reticulo endoplasmático (RE). PDI é essencial à regulação da proteostase por ter função no enovelamento oxidativo de proteínas e na via de degradação associada ao RE (ERAD). Além disso, PDI interage fisicamente e regula a atividade de NADPH oxidases, e fora da célula é um regulador redox essencial à atividade de proteínas extracelulares. Este pool epi/pericelular da PDI (pecPDI) regula função de proteínas de membrana/secretadas, como integrinas, glicoproteínas gp120 do virus HIV e outra

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6

Pyburn, Jaeden, and Matthew Keasey. "Development of PDIA3 and VDR Knockout Human Osteosarcoma SaOs-2 Cells Using CRISPR-Cas9." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/59.

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Intro: Hypovitaminosis D (vitamin D deficiency) has been observed in ageing patients with brain calcification and loss of the vitamin D receptor leads to abnormal calcification of the basal ganglia and thalamus. We have found that vitamin D can reverse calcification of human osteosarcoma SaOs-2 cells in vitro, in apparent contrast to its known effects of increasing bone strength in patients with Rickets and Osteomalacia. Vitamin-D functions through binding to two Vitamin-D responsive proteins; the vitamin D receptor (VDR) and Protein Disulfide isomerase A3 (PDIA3). The aim of this project was

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7

Linden, Liana de Salles van der. "Avaliação da proteína disulfeto isomerase A1 (PDIA1) como marcador para a qualidade seminal em garanhões." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/182414.

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O período de puberdade, em equinos, define-se pela aparição de espermatozóides maduros no ejaculado de animais jovens, bem como a maturação das funções endócrinas. Os espermatozóides precisam passar por um processo de maturação no epidídimo. Para se obter marcadores moleculares que permitam estabelecer a fertilidade de um garanhão, é necessário um melhor conhecimento das proteínas presentes em espermatozóides imaturos e maduros, uma das quais é a PDI (proteína dissulfeto-isomerase). A PDI foi descrita também como importante marcador de fertilidade no plasma seminal e espermatozóides de diversa

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8

Bougnoux, Anne-Claire. "Identification et caractérisation de biomarqueurs associés à la progression tumorale du mélanome malin cutané : implication de TRAP1 et PDIA4." Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON1T014.

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Bien que le mélanome malin cutané (MMC) ne représente que 10% des cancers cutanés, il en est la forme la plus agressive et est responsable de 90% des décès dus aux cancers de la peau. Son incidence ne cesse d'augmenter ces dernières années et atteint 10.8 cas pour 100 000 habitants chez les hommes et 11 chez les femmes. La survie médiane des patients atteint de mélanome à un stade avancé est de 6.2 mois et seulement 1 patient sur 4 est encore en vie à 1an. Le diagnostic du mélanome est uniquement histopathologique et seul l'examen de la biopsie permet de le poser définitivement. De la même faç

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9

Doroudi, Maryam. "Essential roles of Pdia3/PLAA receptor complex and CaMKII IN 1α,25(OH)₂D₃ and Wnt5a calcium-dependent signaling pathways in osteoblasts and chondrocytes". Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53427.

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The vitamin D metabolite 1,25-dihydroxyvitamin D3 [1α,25(OH)2D3] plays an important role in the regulation of musculoskeletal growth and differentiation. 1α,25(OH)2D3 mediates its effects on cells, including chondrocytes and osteoblasts, through the classical nuclear 1α,25(OH)2D3 receptor. Additionally, recent evidence indicates that several cellular responses to 1α,25(OH)2D3 are mediated via a rapid, calcium-dependent membrane-mediated pathway. These actions of 1α,25(OH)2D3 can be blocked by antibodies to protein-disulfide isomerase family A, member 3 (Pdia3), indicating that it is part of th

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10

Goncalves, Renata. "Interactions entre la signalisation estrogénique et la vitamine D dans les cellules testiculaires." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC411/document.

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La 1α,25(OH)2 vitamine D3 (1,25-D3) est synthétisée à partir du cholestérol par l'exposition solaire de la peau. Les effets de cette hormone sont médiées par le récepteur de la vitamine D (VDR) dans le noyau et à la membrane plasmique, et avec le récepteur PDIA3 ils médient des effets génomiques et non-génomique. La vitamine D joue un rôle important dans la reproduction, puisque la réduction de la fertilité a été observée chez les rats déficients en vitamine D. L'estradiol (E2) est synthétisé à partir de la testostérone par l'enzyme aromatase (CYP19). L’E2 a des effets génomiques et non génomi

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11

Du, Plooy Louis Johannes. "Thinking differently about local economic development and governance in secondary cities in South Africa - A conceptual analysis of the possibilities of problem driven iterative adaption (PDIA)." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25268.

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Local economic development successes and failures at municipal level, and specifically in secondary cities in South Africa, is deeply influenced by the constitutional imperatives for establishing developmental local government. The local planning, economic development and policy frameworks introduced between 1999 and 2006 were largely based on, and moulded according to, the wave of new public management paradigms and public sector reform 'good governance best practises' implemented in South Africa post the 1994 democratic elections. The study makes two claims about municipal designs and practi

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12

McLane, Jesica Mata. "Investigation of 1alpha,25-dihydroxy vitamin D3 membrane receptor ERp60 in adipocytes from male and female lean and obese mice." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31793.

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Thesis (M. S.)--Biomedical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Dr. Barbara Boyan; Committee Co-Chair: Dr. Zvi Schwartz; Committee Member: Dr. Hanjoong Jo. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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13

Kuo, Tien-Fen, and 郭恬岎. "Pdia4 characterization and generation of Pdia4 knockout mice." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/bfaetd.

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14

GIAMOGANTE, FLAVIA. "Functional characterization of protein PDIA3." Doctoral thesis, 2018. http://hdl.handle.net/11573/1209569.

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PDIA3 protein is a prominent member of the PDI family that has attracted a significant attention by the research community. It is also becoming increasingly evident that PDIA3 could be a pharmacological target in different pathological conditions, though the mechanisms in which it is involved are not completely understood. For this reason, my PhD project puts the spotlight on the PDIA3 involvement in disease processes, focusing on Alzheimer disease and platelet aggregation, and then characterizing its new features and roles in the development of the aforementioned diseases. At present, no sele

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15

MARROCCO, ILARIA. "PDIA3: a versatile and pleiotropic protein disulfide isomerase." Doctoral thesis, 2017. http://hdl.handle.net/11573/926418.

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Introduction PDIA3, also known as ERp57 or GRP58, is a member of the protein disulfide isomerase family; its structure is characterized by four thioredoxin-like domains: a, b, b’ and a’; a and a’ domains contain the redox active site while b and b’ domains are redox inactive. PDIA3 is localized predominantly in the ER (Endoplasmic Reticulum), where it is involved in the correct folding of newly synthesized glycoproteins and in the assembly of the MHC class I complex, but it is also present in the cytosol, in the nucleus and on the cell surface. PDIA3 is a multifunctional protein disulfide is

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16

Chung, Yu-Yu, and 鍾佑瑜. "Study on Function of Pdia4 in T Cells by Lentiviral Particle-mediated Gene Transfection." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/00007591013966513478.

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17

Sunil, Sanadi Dilip. "Dynamics of Hollow Cone Spray in an Unconfined, Isothermal, Co-Annular Swirling Jet Environment." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3866.

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The complex multiphase flow physics of spray-swirl interaction in both reacting and non-reacting environment is of fundamental and applied significance for a wide variety of applications ranging from gas turbine combustors to pharmaceutical drug nebulizers. Understanding the intricate dynamics between this two phase flow field is pivotal for enhancing mixing characteristics, reducing pollutant emissions and increasing the combustion efficiency in next generation combustors. The present work experimentally investigates the near and far-field break-up, dispersion and coalescence characteristics

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18

Sunil, Sanadi Dilip. "Dynamics of Hollow Cone Spray in an Unconfined, Isothermal, Co-Annular Swirling Jet Environment." Thesis, 2015. http://etd.iisc.ernet.in/2005/3866.

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The complex multiphase flow physics of spray-swirl interaction in both reacting and non-reacting environment is of fundamental and applied significance for a wide variety of applications ranging from gas turbine combustors to pharmaceutical drug nebulizers. Understanding the intricate dynamics between this two phase flow field is pivotal for enhancing mixing characteristics, reducing pollutant emissions and increasing the combustion efficiency in next generation combustors. The present work experimentally investigates the near and far-field break-up, dispersion and coalescence characteristics

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19

Perala, Siva Rama Krishna. "Alternative Mechanisms for Size Control in Synthesis of Nanoparticles - Population Balance Modelling and Experimental Studies." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/3361.

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The extensive growth of nanotechnology has necessitated the development of economical and robust methods for large scale production of nanomaterials. It requires detailed quantitative understanding of lab-scale processes to enable effective scale-up and development of new contacting strategies for their controlled synthesis. In this thesis, attempts are made in both the directions using experimental and modelling approaches for synthesis of different nanoparticles. The two-phase Brust--Schiffrin protocol for the synthesis of gold nanoparticles was investigated first. The mechanism of transfer

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20

Perala, Siva Rama Krishna. "Alternative Mechanisms for Size Control in Synthesis of Nanoparticles - Population Balance Modelling and Experimental Studies." Thesis, 2013. http://etd.iisc.ernet.in/2005/3361.

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The extensive growth of nanotechnology has necessitated the development of economical and robust methods for large scale production of nanomaterials. It requires detailed quantitative understanding of lab-scale processes to enable effective scale-up and development of new contacting strategies for their controlled synthesis. In this thesis, attempts are made in both the directions using experimental and modelling approaches for synthesis of different nanoparticles. The two-phase Brust--Schiffrin protocol for the synthesis of gold nanoparticles was investigated first. The mechanism of transfer

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21

Prasad, Boggavarapu V. V. S. U. "Experimental Studies on Biodiesel Spray Characteristics : Effects of Evaporation & Nozzle Cavitation." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3738.

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Vegetable oil methyl esters obtained by transesterification of vegetable oils are considered to be suitable alternative fuels for diesel engines. However, higher viscosity, surface tension and boiling temperatures of biodiesels may adversely affect spray characteristics as compared to those of diesel. Thus, spray characteristics of Jatropha Methyl Ester (JME) are studied by comparing them to those of diesel in a high-pressure chamber with optical access to simulate the actual in-cylinder conditions. Also, the effect of inner-nozzle cavitation on JME and diesel sprays is studied by utilizing tw

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22

Prasad, Boggavarapu V. V. S. U. "Experimental Studies on Biodiesel Spray Characteristics : Effects of Evaporation & Nozzle Cavitation." Thesis, 2016. http://etd.iisc.ernet.in/2005/3738.

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Vegetable oil methyl esters obtained by transesterification of vegetable oils are considered to be suitable alternative fuels for diesel engines. However, higher viscosity, surface tension and boiling temperatures of biodiesels may adversely affect spray characteristics as compared to those of diesel. Thus, spray characteristics of Jatropha Methyl Ester (JME) are studied by comparing them to those of diesel in a high-pressure chamber with optical access to simulate the actual in-cylinder conditions. Also, the effect of inner-nozzle cavitation on JME and diesel sprays is studied by utilizing tw

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23

Sinha, Anubhav. "Experimental and Numerical Studies on Spray in Crossflow." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/3058.

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The phenomenon of spray in crossflow is of relevance in gas turbine combustor development. The current work focuses on spray in crossflow rather than liquid jet in crossflow from the standpoint of enhancing fuel dispersion and mixing. Specifically, the first part of the work involves study of spray structure, droplet sizing, and velocimetry for sprays of water and ethanol in a crossflow under ambient conditions. Laser-based diagnostic techniques such as Particle/Droplet Image Analysis (PDIA) and Particle Tracking Velocimetry (PTV) are utilized. Using spray structure images, trajectory equation

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24

Sinha, Anubhav. "Experimental and Numerical Studies on Spray in Crossflow." Thesis, 2016. http://hdl.handle.net/2005/3058.

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The phenomenon of spray in crossflow is of relevance in gas turbine combustor development. The current work focuses on spray in crossflow rather than liquid jet in crossflow from the standpoint of enhancing fuel dispersion and mixing. Specifically, the first part of the work involves study of spray structure, droplet sizing, and velocimetry for sprays of water and ethanol in a crossflow under ambient conditions. Laser-based diagnostic techniques such as Particle/Droplet Image Analysis (PDIA) and Particle Tracking Velocimetry (PTV) are utilized. Using spray structure images, trajectory equation

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