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Journal articles on the topic 'PDIA6'

Author: Grafiati

Published: 10 March 2023

Last updated: 31 July 2025

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1

Passam, Freda H., Angelina Lay, Alexander Dupuy, et al. "Protein Disulphide Isomerase 6 (PDIA6) Attenuates Platelet Endoplasmic Reticulum Stress and Secretion in a Mouse Model." Blood 138, Supplement 1 (2021): 3138. http://dx.doi.org/10.1182/blood-2021-152307.

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Abstract Background: Platelet hyperreactivity involves increased secretion of their granule content which promotes platelet aggregation and thrombosis. Platelet hyperreactivity is observed in conditions such as diabetes mellitus and is associated with decreased cardioprotective effect from antiplatelet agents in this patient group. Diabetes is associated with increased endoplasmic reticulum (ER) stress from hyperglycemia and hyperlipidemia. Protein disulphide isomerase 6 (PDIA6) is an endoplasmic reticulum protein which folds nascent proteins by reduction and oxidation of their disulphide bond

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2

Cheng, He-Peng, Qian Liu, Yang Li, Xiao-Dong Li, and Chao-Yang Zhu. "The Inhibitory Effect of PDIA6 Downregulation on Bladder Cancer Cell Proliferation and Invasion." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 25, no. 4 (2017): 587–93. http://dx.doi.org/10.3727/096504016x14761811155298.

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Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close association with various cancers. However, there has been little investigation into the biological functions of PDIA6 in bladder cancer (BC). In this study, we explored the expression pattern and functional significance of PDIA6 in BC. We found that PDIA6 was overexpressed in BC tissues and cell lines. The in vitro study showed that PDIA6 downregulation significantly inhibited BC proliferation and invasion. In addition, the in vivo experiment demonstrated that PDIA6 downregulation decre

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3

Kim, Tae-Wan, Hyang-Hwa Ryu, Song-Yuan Li, et al. "PDIA6 regulation of ADAM17 shedding activity and EGFR-mediated migration and invasion of glioblastoma cells." Journal of Neurosurgery 126, no. 6 (2016): 1829–38. http://dx.doi.org/10.3171/2016.5.jns152831.

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OBJECTIVEIn patients with glioblastoma, local invasion of tumor cells causes recurrence and shortens survival. The goal of this study was to determine whether protein disulfide isomerase (PDI) A6 regulates migration and invasion of glioblastoma cells and the associated factors.METHODSU87MG cells were treated with either PDIA6 or ADAM17 small interfering RNA (siRNA) fragments or with both types of siRNA fragments, and expression was confirmed by reverse transcription–polymerase chain reaction and Western blot. Migration and invasion were assessed using a wound-healing assay, a Matrigel assay, a

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4

Shen, Chien-Heng, Shui-Yi Tung, Wen-Shih Huang, et al. "Comparative Proteomic Identification of Protein Disulphide Isomerase A6 Associated with Tert-Butylhydroperoxide-Induced Liver Injury in Rat Hepatocytes." Cellular Physiology and Biochemistry 45, no. 5 (2018): 1915–26. http://dx.doi.org/10.1159/000487968.

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Background/Aims: Oxidants are important human toxicants. They have been implicated in the occurrence and development of liver diseases. Increased intracellular tert-butylhydroperoxide (t-BHP) may be critical for oxidant toxicity, and is commonly used for evaluating mechanisms involving oxidative stress, but the method remains controversial. Methods: Primary cultures of hepatocytes as well as human Hep G2 and mouse FL83B liver cells were obtained. Cell viability was measured by annexin V–FITC/propidium iodide and DAPI staining to determine the effects of t-BHP treatment on acute liver injury. A

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5

Ramos, F. S., L. T. R. Serino, C. M. S. Carvalho, et al. "PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer." Genetics and Molecular Research 14, no. 2 (2015): 6960–67. http://dx.doi.org/10.4238/2015.june.26.4.

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Vieujean, S., S. Hu, E. Bequet, et al. "P013 Potential Role of Epithelial Protein Disulphide Isomerases in Crohn’s Disease Fibrosis." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S134—S135. http://dx.doi.org/10.1093/ecco-jcc/jjab076.142.

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Abstract Background Intestinal fibrosis is a common complication of Crohn’s disease (CD) characterized by an accumulation of fibroblasts differentiating into activated myofibroblasts secreting excessive extracellular matrix. In in-vitro experiments, this myofibroblastic differentiation is elicited by a whole series of factors among which transforming growth factor-β1 (TGF-β1) seems to play a key role. The potential role of the intestinal epithelium in this fibrotic process remains poorly defined. Methods We performed a pilot proteomic study comparing the proteome of surface epithelium isolated

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7

Tufo, G., A. W. E. Jones, Z. Wang, et al. "The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma." Cell Death & Differentiation 21, no. 5 (2014): 685–95. http://dx.doi.org/10.1038/cdd.2013.193.

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Zhou, Ping, Lakshmanan K. Iyer, Hani Hassoun, James E. Hoffman, Heather Landau, and Raymond L. Comenzo. "Cyclin D1 Overexpression In Clonal Plasma Cells In Systemic AL Amyloidosis Is Associated with Differential Expression of Protein Quality Control Genes and Bias In Clonal Germline IgVL donor Gene Use." Blood 116, no. 21 (2010): 4043. http://dx.doi.org/10.1182/blood.v116.21.4043.4043.

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Abstract Abstract 4043 Cyclin D1 (CCND1) overexpression in AL plasma cells (PC) is associated with patient characteristics such as production of free immunoglobulin (Ig) light chains (FLC) without an intact M-protein (that is, without partner Ig heavy chains), increased cardiac biomarkers and shorter survival (Amyloid 2010;17(S1):61a; Blood 2008;111:4700; Haematologica 2009;94:380). The molecular ramifications of CCND1 overexpression within AL PC clones have not been described. To study these associations, we used CD138+ AL PC from 69 untreated AL patients at diagnosis for (1) gene expression

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9

Özenver, Nadire, and Thomas Efferth. "Identification of Prognostic and Predictive Biomarkers and Druggable Targets among 205 Antioxidant Genes in 21 Different Tumor Types via Data-Mining." Pharmaceutics 15, no. 2 (2023): 427. http://dx.doi.org/10.3390/pharmaceutics15020427.

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(1) Background: Oxidative stress is crucial in carcinogenesis and the response of tumors to treatment. Antioxidant genes are important determinants of resistance to chemotherapy and radiotherapy. We hypothesized that genes involved in the oxidative stress response may be valuable as prognostic biomarkers for the survival of cancer patients and as druggable targets. (2) Methods: We mined the KM Plotter and TCGA Timer2.0 Cistrome databases and investigated 205 antioxidant genes in 21 different tumor types within the context of this investigation. (3) Results: Of 4347 calculations with Kaplan–Mei

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Gorasia, Dhana G., Nadine L. Dudek, Helena Safavi-Hemami, et al. "A prominent role of PDIA6 in processing of misfolded proinsulin." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864, no. 6 (2016): 715–23. http://dx.doi.org/10.1016/j.bbapap.2016.03.002.

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SMULDERS-SRINIVASAN, TORA K., SARAH E. JENKINSON, LOUISE J. BROWN, VASILEIOS P. LENIS, and ROSEMARY BASS. "PDIA6andMaspinin Prostate Cancer." Anticancer Research 43, no. 12 (2023): 5331–40. http://dx.doi.org/10.21873/anticanres.16736.

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12

Jia, Wei, Xiaobing Zhang, Bo Kang, et al. "Abstract 3045: Development of a first-in-class PDIA6/IRE1 modulator for selectively sensitizing cancer cells to ER stress and regulated cell death." Cancer Research 85, no. 8_Supplement_1 (2025): 3045. https://doi.org/10.1158/1538-7445.am2025-3045.

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Abstract Background: A high proliferation rate of cancer cells requires increased protein synthesis leading to ER stress, a condition characterized by accumulation of unfolded or misfolded proteins in the ER lumen. Three interconnected Unfolded Protein Response (UPR) pathways, IRE1, PERK, and ATF6 pathways, are activated to relieve ER stress or to initiate apoptosis if prolonged strong ER stress remains unsolved. Thus, the chronically elevated ER stress levels in cancer cells constitute an Achilles’ heel and provide a window of opportunity for development of therapeutic regimens. Despite multi

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13

Paglia, Giuliano, Lorenzo Antonini, Laura Cervoni, et al. "A Comparative Analysis of Punicalagin Interaction with PDIA1 and PDIA3 by Biochemical and Computational Approaches." Biomedicines 9, no. 11 (2021): 1533. http://dx.doi.org/10.3390/biomedicines9111533.

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In a previous work, it was shown that punicalagin, an active ingredient of pomegranate, is able to bind to PDIA3 and inhibit its disulfide reductase activity. Here we provide evidence that punicalagin can also bind to PDIA1, the main expressed form of protein disulfide isomerase (PDI). In this comparative study, the affinity and the effect of punicalagin binding on each protein were evaluated, and a computational approach was used to identify putative binding sites. Punicalagin binds to either PDIA1 or PDIA3 with a similar affinity, but the inhibition efficacy on protein reductase activity is

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Kong, Xianghui, Hanhan Yao, Jianfeng Ren, et al. "PDIA6 involves the thermal stress response of razor clam, Sinonovacula constricta." Fish & Shellfish Immunology 131 (December 2022): 766–74. http://dx.doi.org/10.1016/j.fsi.2022.10.055.

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15

Freitas, C. P., I. Clemente, T. Mendes, and C. Novo. "Trichinella spiralis: genome database searches for the presence and immunolocalization of protein disulphide isomerase family members." Journal of Helminthology 90, no. 1 (2014): 62–67. http://dx.doi.org/10.1017/s0022149x14000807.

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AbstractThe formation of nurse cells in host muscle cells duringTrichinella spiralisinfection is a key step in the infective mechanism. Collagen trimerization is set up via disulphide bond formation, catalysed by protein disulphide isomerase (PDI). InT. spiralis, some PDI family members have been identified but no localization is described and no antibodies specific forT. spiralisPDIs are available. In this work, computational approaches were used to search for non-described PDIs in theT. spiralisgenome database and to check the cross-reactivity of commercial anti-human antibodies withT. spira

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16

Bequet, E., C. Salée, N. Bletard, et al. "P194 Characterization of Protein Disulfide Isomerases in adult and pediatric Crohn’s Disease and association with inflammation and fibrosis." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i347. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0324.

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Abstract Background Evolution of Crohn's disease (CD) is often marked by fibrostenotic complications and available biotherapies cannot prevent or treat intestinal fibrosis. The pathophysiological mechanisms of intestinal fibrosis are multiple and poorly understood. The intestinal epithelium probably plays a key role. The endoplasmic reticulum stress (ERS) is involved in the pathophysiology of IBD and in fibrosis. Protein disulfide isomerases (PDIs) take part in the ER stress response, but their precise roles and associations with CD remain poorly characterized. We investigated the distribution

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17

Eletto, Daniela, Davide Eletto, Sarah Boyle, and Yair Argon. "PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1." FASEB Journal 30, no. 2 (2015): 653–65. http://dx.doi.org/10.1096/fj.15-275883.

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18

Meschiari, Giorgia, Marco Minacori, Sara Fiorini, Mariassunta Tedesco, Margherita Eufemi, and Fabio Altieri. "Analysis of Punicalin and Punicalagin Interaction with PDIA3 and PDIA1." International Journal of Molecular Sciences 25, no. 19 (2024): 10531. http://dx.doi.org/10.3390/ijms251910531.

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PDIA3 is a pleiotropic protein primarily located in the endoplasmic reticulum where it is involved in protein folding, catalyzing the formation, breakage, and rearrangement of disulfide bonds. PDIA3 is implicated in numerous pathologies such as cancer, inflammation, and neurodegeneration. Although punicalagin has been proven to be a highly promising PDIA3 inhibitor and can be used as target protein in glioblastoma, it does not have sufficient selectivity for PDIA3 and is a quite-large molecule. With the aim of finding punicalagin derivatives with a simplified structure, we selected punicalin,

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19

Yan, Chao, Xiaolei Song, Su Wang, Jinhai Wang, and Lu Li. "Knockdown of PDIA6 Inhibits Cell Proliferation and Enhances the Chemosensitivity in Gastric Cancer Cells." Cancer Management and Research Volume 12 (November 2020): 11051–62. http://dx.doi.org/10.2147/cmar.s267711.

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20

Gao, Huijun, Bing Sun, Hailu Fu та ін. "PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway". Oncotarget 7, № 33 (2016): 53289–98. http://dx.doi.org/10.18632/oncotarget.10795.

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Gao, Huijun, Bing Sun, Hailu Fu та ін. "Retraction: PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway". Oncotarget 15, № 1 (2024): 219. http://dx.doi.org/10.18632/oncotarget.28522.

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22

Bang, J. I., D. W. Bae, Y. S. Kwon, et al. "34 DIFFERENTIALLY EXPRESSED PROTEINS OF EARLY-STAGE PLACENTA DERIVED FROM CLONED CAT EMBRYOS USING PROTEOMICS ANALYSIS." Reproduction, Fertility and Development 24, no. 1 (2012): 129. http://dx.doi.org/10.1071/rdv24n1ab34.

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We have previously demonstrated that differentially expressed proteins affect abnormal development and function of cloned term placenta. This is associated with cloned fetus morbidity and mortality. We also frequently observed loss of the cloned fetus and failed development during early pregnancy periods. To confirm the pattern of important gene expression in cloned placenta during pre- and post-implantation, we investigated expression pattern of proteins in early stage (21 days) domestic cat placentas of cloned embryo transfer (CEP; n = 2) and artificial insemination (CP; n = 4) derived pregn

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23

Groenendyk, J., Z. Peng, E. Dudek, et al. "Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis." Science Signaling 7, no. 329 (2014): ra54. http://dx.doi.org/10.1126/scisignal.2004983.

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24

Ma, Yihui, Peiyi Xia, Zhengyang Wang, Jingjing Xu, Lan Zhang та Yanan Jiang. "PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1". Neoplasia 23, № 9 (2021): 912–28. http://dx.doi.org/10.1016/j.neo.2021.07.004.

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25

Sha, Zhen-Xia, Hong Liu, Qi-Long Wang, et al. "Channel catfish (Ictalurus punctatus) protein disulphide isomerase, PDIA6: Molecular characterization and expression regulated by bacteria and virus inoculation." Fish & Shellfish Immunology 33, no. 2 (2012): 220–28. http://dx.doi.org/10.1016/j.fsi.2012.04.014.

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Bai, Yuxin, Xuefeng Liu, Xiaoyu Qi, et al. "PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway." EBioMedicine 42 (April 2019): 311–25. http://dx.doi.org/10.1016/j.ebiom.2019.03.045.

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Kiouptsi, Klytaimnistra, Stefanie Finger, Venkata S. Garlapati, et al. "Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice." Biology Open 8, no. 1 (2018): bio038851. http://dx.doi.org/10.1242/bio.038851.

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28

Li, Shenjie, Wei Xiang, Junjie Tian, et al. "Bone Marrow-Derived Mesenchymal Stem Cells Differentially Affect Glioblastoma Cell Proliferation, Migration, and Invasion: A 2D-DIGE Proteomic Analysis." BioMed Research International 2021 (February 11, 2021): 1–13. http://dx.doi.org/10.1155/2021/4952876.

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Bone marrow-derived mesenchymal stem cells (BM-MSCs) display high tumor tropism and cause indirect effects through the cytokines they secrete. However, the effects of BM-MSCs on the biological behaviors of glioblastoma multiforme remain unclear. In this study, the conditioned medium from BM-MSCs significantly inhibited the proliferation of C6 cells ( P < 0.05 ) but promoted their migration and invasion ( P < 0.05 ). Two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) proteomic analysis revealed 17 proteins differentially expressed in C6 cells exposed to the BM-MSC-condi

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Chen, Jianmei, Ziyi Wu, Ruxue Chen, et al. "Identification of Genomic Regions and Candidate Genes for Litter Traits in French Large White Pigs Using Genome-Wide Association Studies." Animals 12, no. 12 (2022): 1584. http://dx.doi.org/10.3390/ani12121584.

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The reproductive traits of sows are one of the important economic traits in pig production, and their performance directly affects the economic benefits of the entire pig industry. In this study, a total of 895 French Large White pigs were genotyped by GeneSeek Porcine 50K SNP Beadchip and four phenotypic traits of 1407 pigs were recorded, including total number born (TNB), number born alive (NBA), number healthy piglets (NHP) and litter weight born alive (LWB). To identify genomic regions and genes for these traits, we used two approaches: a single-locus genome-wide association study (GWAS) a

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Souza-Neto, Francisco V., Sara Jiménez-González, Beatriz Delgado-Valero, et al. "The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats." Antioxidants 10, no. 8 (2021): 1274. http://dx.doi.org/10.3390/antiox10081274.

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We have evaluated the role of mitochondrial oxidative stress and its association with endoplasmic reticulum (ER) stress activation in the progression of obesity-related cardiovascular fibrosis. MitoQ (200 µM) was orally administered for 7 weeks to male Wistar rats that were fed a high-fat diet (HFD, 35% fat) or a control diet (CT, 3.5% fat). Obese animals presented cardiovascular fibrosis accompanied by increased levels of extracellular matrix proteins and profibrotic mediators. These alterations were associated with ER stress activation characterized by enhanced levels (in heart and aorta vs.

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Cesarman, Ethel, Mikhail Roshal, Jonathan Reichel, et al. "RNA Sequencing of Hodgkin Lymphoma Reed-Sternberg Cells Uncovers a Plasma Cell Signature and Escape from NK Cell Recognition." Blood 134, Supplement_1 (2019): 549. http://dx.doi.org/10.1182/blood-2019-131163.

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Introduction: Previous gene expression profiling studies of classical Hodgkin lymphoma (cHL) have been confined to cell lines and microdissected HRS cells from tissue biopsies given the difficulty of isolating sparse Hodgkin and Reed-Sternberg (HRS) cells from reactive background tissue. We previously used flow sorting to separate HRS cells from fresh or viably frozen cHL biopsies, and performed the first full exome sequencing of HRS cells. Here we report use of the same cell separation approach to examine the HRS cell transcriptome using RNA sequencing. Methods: We used flow cytometric cell s

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Chai, Jiani, Victoria Alagiozian-Angelova, Paul Rubinstein, Lisa Roth, Ethel Cesarman, and Amy Chadburn. "1202 Evaluation of Endoplasmic Reticulum Protein PDIA6 Expression, a Promising Treatment Target, in Large B Cell Malignancies (cHL, PMBL, and DLBCL)." Laboratory Investigation 105, no. 3 (2025): 103438. https://doi.org/10.1016/j.labinv.2024.103438.

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Direito, Inês, Liliana Monteiro, Tânia Melo, et al. "Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance." Cancers 13, no. 13 (2021): 3195. http://dx.doi.org/10.3390/cancers13133195.

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The protein quality control network, including autophagy, the proteasome and the unfolded protein response (UPR), is triggered by stress and is overactive in acquired antiestrogen therapy resistance. We show for the first time that the aggresome load correlates with apoptosis and is increased in antiestrogen-sensitive cells compared to endocrine-resistant variants. LC-MS/MS analysis of the aggregated proteins obtained after 4OH-tamoxifen and Fulvestrant treatment identified proteins with essential function in protein quality control in antiestrogen-sensitive cells, but not in resistant variant

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Al‐Fadhli, Fatima M., Manal Afqi, Mona Hamza Sairafi, et al. "Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal‐onset diabetes." Clinical Genetics 99, no. 5 (2021): 694–703. http://dx.doi.org/10.1111/cge.13930.

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Herr, Ingrid, Heiner Sähr, Zhefu Zhao, et al. "MiR-127 and miR-376a act as tumor suppressors by in vivo targeting of COA1 and PDIA6 in giant cell tumor of bone." Cancer Letters 409 (November 2017): 49–55. http://dx.doi.org/10.1016/j.canlet.2017.08.029.

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Tian, Yali, Liancheng Li, Hongzhao Long, et al. "Transcriptome Analyses Reveal the Molecular Response of Juvenile Greater Amberjack (Seriola dumerili) to Marine Heatwaves." Animals 15, no. 13 (2025): 1871. https://doi.org/10.3390/ani15131871.

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Marine heatwaves (MHWs) have recently become more frequent, intense, and prolonged, posing significant threats to marine life and fisheries. In this study, transcriptomic analysis was employed to investigate the genes and pathways in Seriola dumerili that respond to MHW-induced stress at 28 °C (T28) and 32 °C (T32), using 24 °C (T24) as the control. Transcriptome sequencing revealed that 17 differentially expressed genes (DEGs) belonging to the heat shock protein (HSP) families—HSP30, HSP40, HSP70, and HSP90—were significantly upregulated under short-lasting MHW stress in the T24-4d vs. T32-4d

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Huang, Yan, Huimin Yan, Yanqing Yang, Jinfei Zhou, Qijun Xu, and Meng Hu. "Sub‐regulação do miR‐181a atenua o estresse oxidativo induzido por H2O2 e a senescência celular atuando sobre PDIA6 em fibroblastos do prepúcio humano." Anais Brasileiros de Dermatologia (Versão em Português) 98, no. 1 (2023): 17–25. https://doi.org/10.1016/j.abdp.2022.10.003.

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Kullmann, Maximilian, Ganna V. Kalayda, Malte Hellwig, et al. "Assessing the contribution of the two protein disulfide isomerases PDIA1 and PDIA3 to cisplatin resistance." Journal of Inorganic Biochemistry 153 (December 2015): 247–52. http://dx.doi.org/10.1016/j.jinorgbio.2015.08.028.

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Shide, Kotaro, Takuro Kameda, Ayako Kamiunten, et al. "The Role of Calreticulin in Normal Hematopoiesis and Neoplastic Hematopoiesis of Myeloproliferative Neoplasms." Blood 134, Supplement_1 (2019): 309. http://dx.doi.org/10.1182/blood-2019-130034.

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Mutations in the Calreticulin (CALR) gene were identified in cases of myeloproriferative neoplasms (MPNs), and various functions of the CALR mutant protein are being elucidated. On the other hand, few data are available on the role of CALR in the hematopoietic system. The knockout (KO) mice of Calr are impaired in expression of transcription factors necessary for cardiac development and are embryonic lethal. To clarify the role of CALR in normal hematopoiesis and MPN pathogenesis, we generated hematopoietic cell-specific Calr KO mice. Mice carrying floxed allele targeted exons 4-7 of Calr (Cal

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Kibitov, A., A. Rakitko, E. Kasyanov, et al. "Genome-wide association study of depression symptoms using online self-questionnaires in the Russian population cohort: preliminary results." European Psychiatry 65, S1 (2022): S327. http://dx.doi.org/10.1192/j.eurpsy.2022.832.

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Introduction Depression is a chronic, recurrent mental disorder with a moderate level of genetic impact. Modern GWAS of depression require extra-large sample sizes and new effective, clinically sensitive, objective and simple to fill online phenotyping tools for population studies are necessary today. Objectives Aim: to test online phenotyping tools based on clinical and psychometric instruments to evaluate depressive symptoms in population cohort for using in GWAS Methods Participants: 2610 Russian-speaking respondents- clients of Genotek Ltd., provider of genetic testing services in Russian

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Zhou, zhaoming, Mingyao Lai, Jiangfen Zhou, et al. "TAMI-11. INCREASED M1 MACROPHAGE INFILTRATION CORRELATED WITH POOR PROGNOSIS OF WHO IV GLIOMAS." Neuro-Oncology 23, Supplement_6 (2021): vi200. http://dx.doi.org/10.1093/neuonc/noab196.795.

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Abstract BACKGROUND Gliomas are the malignancy with a poor prognosis. Our previous database mining study demonstrated that M1 macrophage infiltration predicted the survival of GBM patients. Here in this study, we further explored the findings. METHODS RNA-seq was performed on 90 WHO IV glioma tissue samples. The sequencing data was investigated with xCell for the cell infiltration levels, and the M1 macrophage infiltration was further analyzed for the prognostic prediction effect with overall survival (OS) data. Differentially expressed genes (DEGs) were calculated between groups and the hub g

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Herrero, Ana B., Quwaider Dalia, Luis Antonio Corchete Sanchez, Ramon Garcia-Sanz, and Norma Gutierrez. "FAM46C Controls Antibody Production By the Polyadenylation of Ig mRNAs and Inhibits Cell Migration in Multiple Myeloma." Blood 132, Supplement 1 (2018): 1880. http://dx.doi.org/10.1182/blood-2018-99-111787.

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Abstract FAM46C, which is frequently mutated in multiple myeloma (MM), has recently been shown to encode a non-canonical poly(A) polymerase (ncPAP). However, its target mRNAs and its role in MM pathogenesis remain largely unknown. Using CRISPR-Cas9 technology and gene expression analysis we found that inactivation of FAM46C in MM downregulates immunoglobulins (Igs) and several mRNAs encoding ER-resident proteins, including some involved in unfolded protein response (UPR), such as PDIA6, ERP44 and EDEM2, and others that affect glycosylation, such as SSR4, AGA and DDOST. We also found that FAM46

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Pinto, Rute D., Ana R. Moreira, Pedro J. B. Pereira, and Nuno M. S. dos Santos. "Two thioredoxin-superfamily members from sea bass (Dicentrarchus labrax, L.): Characterization of PDI (PDIA1) and ERp57 (PDIA3)." Fish & Shellfish Immunology 35, no. 4 (2013): 1163–75. http://dx.doi.org/10.1016/j.fsi.2013.07.024.

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Fellenberg, Jörg, Heiner Sähr, Pierre Kunz, et al. "Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6." Cancer Letters 371, no. 1 (2016): 134–41. http://dx.doi.org/10.1016/j.canlet.2015.10.039.

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Fang, Dengpan, Yuanqiao He, Yun Yi, Jiaqi Mei, and Cundong Liu. "Hub gene associated with prognosis in bladder cancer is a novel therapeutic target." PeerJ 11 (August 16, 2023): e15670. http://dx.doi.org/10.7717/peerj.15670.

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Objective Bladder cancer is a clinical and social conundrum due to its high incidence and recurrence rate. It is urgent to find new targets for the diagnosis and treatment of bladder cancer and improve the prognosis and survival rate of bladder cancer patients. We sought a prognosis-related gene, built related models of evaluated bladder cancer and identified the function of the hub gene in bladder cancer. Methods We downloaded the data of bladder cancer patients from the TCGA database, and used differentially expressed genes (DEGs), copy number variation (CNV) and survival analysis to scan th

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Liu, Yang, Hua He, Zimu Song, Zheng Liu, and Kai Zhu. "Lin-28 Homolog B-Activated Protein Disulfide Isomerase A4 Regulates Cell Proliferation, Migration and Invasion of Glioma." Journal of Biomaterials and Tissue Engineering 12, no. 10 (2022): 1972–80. http://dx.doi.org/10.1166/jbt.2022.3129.

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The goal of this study is to elucidate the role of protein disulfide isomerase A4 (PDIA4) in glioma, as well as its regulatory mechanism. Cell transfection was performed to adjust the expression level of PDIA4 and RNA-binding protein lin-28 homolog B (LIN28B). The expression of PDIA4 in human astrocytes and glioma cell lines was determined by quantitative real-time PCR and western blot. CCK-8, colony formation, Transwell and wound-healing assays were applied to determine the capabilities of cells to proliferate, invade and migrate. The connection between PDIA4 and LIN28B was demonstrated by RN

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Yao, Chanjiao, Lingjuan Zeng, Qin Liu, Xiaoxin Qiu, and Chunyan Chen. "LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell Invasion and Migration via Modulating Transcription Factor DDX17." Breast Journal 2023 (September 7, 2023): 1–12. http://dx.doi.org/10.1155/2023/3970444.

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Objective. This study aimed to explore the roles and mechanisms of lncRNA FAM225B and PDIA4 in ovarian cancer. Methods. RT-qPCR and Western blot assays were performed to detect the expression levels of the lncRNAs FAM225B, DDX17, and PDIA4 in the serum of patients with ovarian cancer and cell lines. Cells were transfected with lncRNA FAM225B- and PDIA4-related vectors to determine the malignant phenotypes using functional experiments. The mutual binding of lncRNA FAM225B and DDX17 was verified using RNA pull-down and RIP assays. Results. The expression of lncRNAs FAM225B and PDIA4 was decrease

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Chen, Jiaxuan, Kirill S. Lobachev, Brian J. Grindel та ін. "Chaperone Properties of Pdia3 Participate in Rapid Membrane Actions of 1α,25-Dihydroxyvitamin D3". Molecular Endocrinology 27, № 7 (2013): 1065–77. http://dx.doi.org/10.1210/me.2012-1277.

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Abstract Protein disulfide isomerase family A, member 3 (Pdia3) mediates many of the plasma membrane (PM)-associated rapid responses to 1α,25-dihydroxyvitamin D3 (1α,25[OH]2D3). It is not well understood how Pdia3, which is an endoplasmic reticulum (ER) chaperone, functions as a PM receptor for 1α,25(OH)2D3. We mutated 3 amino acids (K214 and R282 in the calreticulin interaction site and C406 in the isomerase catalytic site), which are important for Pdia3's ER chaperone function, and examined their role in responses to 1α,25(OH)2D3. Pdia3 constructs with and without the ER retention signal KDE

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Hellewell, Andrew L., Kate J. Heesom, Mark A. Jepson, and Josephine C. Adams. "PDIA3/ERp57 promotes a matrix-rich secretome that stimulates fibroblast adhesion through CCN2." American Journal of Physiology-Cell Physiology 322, no. 4 (2022): C624—C644. http://dx.doi.org/10.1152/ajpcell.00258.2021.

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The matricellular glycoprotein thrombospondin-1 (TSP1) has complex roles in the extracellular matrix (ECM) and at cell surfaces, but relatively little is known about its intracellular associations prior to secretion. To search for novel intracellular interactions of TSP1 in situ, we carried out a biotin ligase-based TSP1 interactome screen and identified protein disulfide isomerase A3 (PDIA3/ERp57) as a novel candidate binding protein. In validation, TSP1 and PDIA3 were established to bind in vitro and to colocalize in the endoplasmic reticulum of human dermal fibroblasts (HDF). Loss of PDIA3

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Paglia, Giuliano, Marco Minacori, Giorgia Meschiari, et al. "Protein Disulfide Isomerase A3 (PDIA3): A Pharmacological Target in Glioblastoma?" International Journal of Molecular Sciences 24, no. 17 (2023): 13279. http://dx.doi.org/10.3390/ijms241713279.

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The protein disulfide isomerase A3 (PDIA3) is directly or indirectly involved in various physiopathological processes and participates in cancer initiation, progression and chemosensitivity. However, little is known about its involvement in glioblastoma. To obtain specific information, we performed cellular experiments in the T98G and U−87 MG glioblastoma cell lines to evaluate the role of PDIA3. The loss of PDIA3 functions, either through inhibition or silencing, reduced glioblastoma cells spreading by triggering cytotoxic phenomena. PDIA3 inhibition led to a redistribution of PDIA3, resultin

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