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Journal articles on the topic 'Pediatric diagnostics'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Umarova Mukaddaskhon Abdukadirovna. "Modern Diagnostics and Treatment in the Field of Pediatrics." Texas Journal of Medical Science 21 (June 8, 2023): 4–6. http://dx.doi.org/10.62480/tjms.2023.vol21.pp4-6.

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In this article, feedback on diagnostics and treatment will be discussed in the field of Pediatrics. Pediatrics has undergone many changes in recent years due to advancements in technology, research, and healthcare practices. There is an increasing focus on preventive care in Pediatrics, which involves regular check-ups, screening tests, and vaccinations to prevent disease and promote overall health and wellness. Technology in Diagnosis and Treatment as mentioned earlier, the use of technology in diagnosing and treating pediatric illnesses has been a significant change. There are digital medic

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Khachaturov, Y. A., I. O. Shchederkina, N. F. Plavunov, et al. "Stroke in children and adolescents: topical problems of pre-hospital diagnostics." Russian Archives of Internal Medicine 10, no. 1 (2020): 21–30. http://dx.doi.org/10.20514/2226-6704-2020-10-1-21-30.

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The article is devoted to the urgent problem of pediatrics and pediatric neurology, pre-hospital diagnosis of stroke in children. A review of domestic and foreign literature on the early diagnosis of stroke in children and adolescents, as well as epidemiological data on pediatric stroke, is presented. Particular attention is paid to the features of the symptoms of stroke and stroke-like conditions («stroke masks») in the pediatric population and the analysis of the main factors that influence errors in the early diagnosis of stroke in children and adolescents. Currently, in the diagnosis of is

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Yajima, Hirohisa, Hirokazu Takami, Kentaro Watanabe, et al. "10136- GEN-7 ADDED CLINICAL VALUE OF WHOLE GENOME SEQUENCING FOR PEDIATRIC GLIOMA AND GLIONEURONAL TUMOR." Neuro-Oncology Advances 6, Supplement_4 (2024): iv3. http://dx.doi.org/10.1093/noajnl/vdae173.010.

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Abstract BACKGROUND The fifth edition of the WHO Classification of Tumors of the Central Nervous System incorporates numerous genetic findings in pediatric brain tumor classification, emphasizing the significance of molecular diagnostics. In Japan, Japan Children’s Cancer Group (JCCG) Brain Tumor Committee organizes a central diagnostic system for pediatric brain tumors, including histopathology review and molecular diagnostics through a limited targeted gene analysis. However, comprehensive genome-wide analysis has not been conducted. OBJECTIVE To evaluate the clinical utility of whole genome

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Petryaykina, E. E., I. O. Shchederkina, I. P. Vitkovskaya, et al. "Primary pediatric stroke center in the multidisciplinary pediatric hospital. New reality in pediatrics." City Healthcare 1, no. 1 (2020): 15–30. http://dx.doi.org/10.47619/2713-2617.zm.2020.v1i1;15-30.

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Background. The increase in the number of diagnosed strokes in children, significant distinctive features and complexity of diagnosis, treatment and prevention of cerebrovascular diseases in children compared with adults, the impossibility of direct extrapolation of therapeutic recommendations from adult practice to pediatrics required the creation of specialized primary centers of pediatric stroke in Russia. Purpose. The purpose of this article is to describe the experience of organizing a Center for the treatment of children and adolescents with cerebrovascular diseases (hereinafter referred

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Vlasova, A. V., T. A. Tenovskaya, L. V. Dymnova, et al. "Primary pediatric stroke center in the multidisciplinary pediatric hospital. New reality in pediatrics." City Healthcare 1, no. 1 (2020): 51–59. http://dx.doi.org/10.47619/2713-2617.zm.2020.v1i1;51-59.

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Background. The increase in the number of diagnosed strokes in children, significant distinctive features and complexity of diagnosis, treatment and prevention of cerebrovascular diseases in children compared with adults, the impossibility of direct extrapolation of therapeutic recommendations from adult practice to pediatrics required the creation of specialized primary centers of pediatric stroke in Russia. Purpose. The purpose of this article is to describe the experience of organizing a Center for the treatment of children and adolescents with cerebrovascular diseases (hereinafter referred

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WOJTYŁKO– GOŁOWKIN, ANNA, MACIEJ BAGŁAJ, and ALEKSANDER WOJTYŁKO. "Prenatal diagnostics of aninborndefects." Medical Science Pulse 8, no. 1 (2014): 26–29. http://dx.doi.org/10.5604/01.3001.0003.3157.

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Prenatal diagnosis offers a wide range of tests that can be carried out at various stages of pregnancy in order to conduct early diagnosis of congenital malformations. The purpose of this publication is to discuss the methodology, suitability and availability of prenatal testing. The detection of anatomical abnormalities in utero and postnatal verification of the diagnosis decreases the risk associated with malformation in a significant way. Prenatal detection of the defect requiring the surgical intervention on the first days of the life is particularly important. Intrauterine diagnosing of t

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Ivanitska, T. "PREANALYTICAL ERRORS IN PEDIATRIC LABORATORY DIAGNOSTICS: CAUSES, CONSEQUENCES, AND MITIGATION STRATEGIES." Ukrainian Journal of Laboratory Medicine 3, no. 2 (2025): 42. https://doi.org/10.62151/2786-9288.3.2.2025.12.

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Summary: Preanalytical errors are the most common source of inaccuracy in pediatric laboratory diagnostics, often leading to stress, diagnostic delays, and repeated blood draws. Based on an international literature review and local institutional practices, this work identifies key risk factors (e.g. hemolysis, underfilled tubes, patient misidentification) and presents a structured set of practical interventions. Emphasis is placed on standardized procedures, pediatric-specific tools, and centralized venous sampling to ensure diagnostic reliability and patient safety.

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Wolthers, Ole D. "Molecular Allergy Diagnostics as an Adjunct to Conventional Diagnostics in a Secondary Pediatric Referral Center." Recent Patents on Inflammation & Allergy Drug Discovery 13, no. 1 (2019): 73–76. http://dx.doi.org/10.2174/1872213x13666190610143439.

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Background: Several compositions for determination of specific molecular components in allergens have recently been patented. The role of Molecular Allergy (MA) diagnostics in suspected IgE mediated allergic conditions is currently debated. Guideline reports have concluded that population- based studies involving evaluation of the usefulness of MA diagnostics are needed. Objective: To evaluate the usefulness of MA diagnostics in a secondary pediatric referral center. Methods: A total of 961 children and adolescents aged 0.2-18.8 (mean 7.0) years was included in a prospective observational surv

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Bogdanova, Alevtina Viktorovna, Cyrendorzhi Valer`evich Zandakov, Artem Valer'evich Tishkov, Ludmila Alekszndrovna Zhelenina, Timofei Vladimirovich Sergeev, and Mariya Valentinovna Kuropatenko. "The medical informative systems in pediatric practice - problems and prospects." Pediatrician (St. Petersburg) 6, no. 4 (2015): 140–46. http://dx.doi.org/10.17816/ped64140-146.

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Data on the use of modern medical information systems (MIS) in Russian medicine, including in pediatrics are presented. Advances and problems in creating a single unified MIS, diagnostic information systems are highlighted. Information about existing questionnaires in the area of life quality assessment of healthy and patients suffering from pulmonological profile are provided. The problems of diagnostics of chronic diseases of small bronchial tubes at children are observed. It is important to determine the probability of the diseases formation for the usage of financially-based and informativ

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Krüger, Lukas, Oliver Kamp, Katharina Alfen, Jens Theysohn, Marcel Dudda, and Lars Becker. "Pediatric Carotid Injury after Blunt Trauma and the Necessity of CT and CTA—A Narrative Literature Review." Journal of Clinical Medicine 13, no. 12 (2024): 3359. http://dx.doi.org/10.3390/jcm13123359.

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Background: Blunt carotid injury (BCI) in pediatric trauma is quite rare. Due to the low number of cases, only a few reports and studies have been conducted on this topic. This review will discuss how frequent BCI/blunt cerebrovascular injury (BCVI) on pediatric patients after blunt trauma is, what routine diagnostics looks like, if a computed tomography (CT)/computed tomography angiography (CTA) scan on pediatric patients after blunt trauma is always necessary and if there are any negative health effects. Methods: This narrative literature review includes reviews, systematic reviews, case rep

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Venugopal Reddy Iragamreddy. "The role of Artificial Intelligence in diagnosing rare pediatric diseases: A global perspective." World Journal of Biology Pharmacy and Health Sciences 21, no. 1 (2025): 036–38. https://doi.org/10.30574/wjbphs.2025.21.1.1108.

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Rare pediatric diseases often present significant diagnostic challenges due to their atypical manifestations and lack of familiarity among healthcare providers. Artificial Intelligence (AI) offers transformative potential in bridging diagnostic gaps, particularly in resource-limited settings. This review highlights the role of AI in identifying rare pediatric conditions through advanced algorithms, pattern recognition, and machine learning. By examining successful implementations globally, we explore the potential of AI to revolutionize pediatric diagnostics, address disparities in healthcare

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Paladin, Ivan, Ivan Mizdrak, Mirko Gabelica, Nikolina Golec Parčina, Ivan Mimica, and Franko Batinović. "Foreign Bodies in Pediatric Otorhinolaryngology: A Review." Pediatric Reports 16, no. 2 (2024): 504–18. http://dx.doi.org/10.3390/pediatric16020042.

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Foreign bodies (FBs) in pediatric otorhinolaryngology represent up to 10% of cases in emergency departments (ED) and are primarily present in children under five years old. They are probably the result of children’s curiosity and tendency to explore the environment. Aural and nasal FBs are the most common and accessible, and the removal methods differ depending on the exact location and type of FB, which can be organic or inorganic. A fish bone stuck in one of the palatine tonsils is the most common pharyngeal FB. Laryngopharyngeal FBs can obstruct the upper respiratory tract and thus become a

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Malbari, Fatema. "Pediatric Neuro-oncology." CONTINUUM: Lifelong Learning in Neurology 29, no. 6 (2023): 1680–709. http://dx.doi.org/10.1212/con.0000000000001360.

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ABSTRACT Objective This article reviews the most common pediatric brain tumors, neurocutaneous syndromes, treatment-related neurotoxicities, and the long-term outcomes of survivors. Latest Developments In the era of molecular diagnostics, the classification, management, and prognostication of pediatric brain tumors and neurocutaneous syndromes has been refined, resulting in advancements in patient management. Molecular diagnostics have been incorporated into the most recent World Health Organization 2021 classification. This knowledge has allowed for novel therapeutic approaches targeting the

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Novichkova, Galina A., Ludmila I. Papusha, and Alexander E. Druy. "Innovative Technologies in Pediatric Neuro-Oncology." Annals of the Russian academy of medical sciences 78, no. 5 (2024): 483–91. http://dx.doi.org/10.15690/vramn15999.

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At the present time pediatric neuro-oncology develops rapidly mostly due to the deep understanding of etiology and pathogenesis of the brain tumors in children, widespread introduction of molecular genetic technologies into diagnostic workflow and emergence of targeted therapeutic agents directing to the neoplastic cells. Many tumor entities undistinguishable at the level of histopathology were classified by the molecular techniques and now present as unique disorders. Clinical heterogeneity unraveled by molecular classification is a basis for modern risk stratification approaches. Variety of

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Dzhuzha, Dmytro. "Positron emission tomography in the pediatric oncology." Radiation Diagnostics, Radiation Therapy, no. 2 (2020): 47–59. http://dx.doi.org/10.37336/2707-0700-2020-2-4.

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The methodical features of using of the positron emission tomography with 18F-fluorodeoxyglucose in pediatric oncological patients and variations of normal distribution of radiopharmaceutical in children were revealed. Diagnostic efficacies of PET/CT in different pediatric malignancies were represented. It is showed that the modality is the important additional imaging method of staging, assessment of treatment, and monitoring of the lymphomas, sarcomas and neuroblastomas which can improve the results of treatment. The possibilities of using PET/CT in diagnostics of Wilms’ tumor, hepatoblastom

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Satvaldieva, Elmira, Gulchehra Ashurova, Otabek Fayziev, and Abdumalik Djalilov. "Pediatric surgical sepsis: diagnostics and intensive therapy." ScienceRise: Medical Science, no. 6(45) (November 30, 2021): 34–42. http://dx.doi.org/10.15587/2519-4798.2021.250239.

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The aim: Optimization of diagnostics and schemes of pathogenetic intensive therapy of surgical sepsis in children based on clinical and laboratory criteria and bacteriological monitoring. Materials and methods: The research period is 2018-2020. The object of the study (n=73) – children with surgical pathology (widespread peritonitis, bacterial destruction of the lungs, post-traumatic brain hematomas, abdominal trauma, etc.). Research methods: microbiological monitoring to determine the sensitivity of the microorganism to antibiotics was carried out before and at the stages of treatment (sputum

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Куликова, С. Л., А. В. Кузнецова, С. А. Лихачев, and Ю. Н. Голец. "Pediatric Multiple Sclerosis: Diagnostics and Treatment (Review)." Неврология и нейрохирургия. Восточная Европа, no. 1 (March 23, 2021): 69–81. http://dx.doi.org/10.34883/pi.2021.11.1.034.

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Рассеянный склероз (РС) – хроническое воспалительное аутоиммунное демиелинизирующее нейродегенеративное заболевание центральной нервной системы, клинически проявляющееся гетерогенной неврологической симптоматикой. У 3–5% пациентов с РС заболевание начинается в детском возрасте. РС у детей имеет свои клинические особенности: рецидивно-ремиттирующее течение в 95–98%, более высокая частота рецидивов в течение первых 2–5 лет, большая распространенность демиелинизирующего процесса, в 15% случаев первый эпизод демиелинизации может иметь клинику острого рассеянного энцефаломиелита. В то же время у де

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OKUDA, T., R. FISHER, and J. DOWNING. "Molecular diagnostics in pediatric acute lymphoblastic leukemia." Molecular Diagnosis 1, no. 2 (1996): 139–51. http://dx.doi.org/10.1016/s1084-8592(96)70029-2.

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Elmira, Satvaldieva, Ashurova Gulchehra, Fayziev Otabek, and Djalilov Abdumalik. "Pediatric surgical sepsis: diagnostics and intensive therapy." ScienceRise: Medical Science, no. 6(45) (November 30, 2021): 34–42. https://doi.org/10.15587/2519-4798.2021.250239.

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<strong>The aim:</strong> Optimization of diagnostics and schemes of pathogenetic intensive therapy of surgical sepsis in children based on clinical and laboratory criteria and bacteriological monitoring. <strong>Materials and methods:</strong> The research period is 2018-2020. The object of the study (n=73) – children with surgical pathology (widespread peritonitis, bacterial destruction of the lungs, post-traumatic brain hematomas, abdominal trauma, etc.). Research methods: microbiological monitoring to determine the sensitivity of the microorganism to antibiotics was carried

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Serik, G., K. Kirgizov, G. Muftakhova, S. Kogan, and S. Varfolomeeva. "Continuous Medical Education in Pediatric Oncology As Successful Approach for Improvement of Early Diagnostics and Treatment." Journal of Global Oncology 4, Supplement 2 (2018): 165s. http://dx.doi.org/10.1200/jgo.18.62100.

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Background and context: Continuous medical education (CME) is very important in improvement of knowledge in all field of pediatrics. CME in pediatric oncology could be aimed both for oncologists and pediatricians. Aim: We aimed to organize CME system in the field of pediatric oncology for oncologists and pediatricians. Strategy/Tactics: Continuous education for improvement of knowledge for all pediatric oncologists and pediatricians based on Russian CME system. This system was organized by the Ministry of Health and National Medical Chamber and based on continuous work of professional medical

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Erdomaeva, Ya A., K. I. Kirgizov, S. A. Kogan, et al. "Importance of the early diagnostics in pediatric oncology and hematology." Pediatria. Journal named after G.N. Speransky 102, no. 3 (2023): 107–14. http://dx.doi.org/10.24110/0031-403x-2023-102-3-107-114.

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Late diagnostics of oncological diseases (OD) in children accounts for significant deaths in pediatric oncology. As a result of it the overall survival rate is decreasing and the level of complications is increasing. There are no effective screening programs for malignant neoplasms in children as yet. Programs intent to spread the early OD diagnostics require significant efforts in the fields of increasing of the oncological awareness among practitioners and optimization of routing. The Article provides up-to-date information on the importance of early diagnostics in pediatric oncology, variou

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Jakhar, Shailja, Alexis A. Bitzer, Loreen R. Stromberg, and Harshini Mukundan. "Pediatric Tuberculosis: The Impact of “Omics” on Diagnostics Development." International Journal of Molecular Sciences 21, no. 19 (2020): 6979. http://dx.doi.org/10.3390/ijms21196979.

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Tuberculosis (TB) is a major public health concern for all ages. However, the disease presents a larger challenge in pediatric populations, partially owing to the lack of reliable diagnostic standards for the early identification of infection. Currently, there are no biomarkers that have been clinically validated for use in pediatric TB diagnosis. Identification and validation of biomarkers could provide critical information on prognosis of disease, and response to treatment. In this review, we discuss how the “omics” approach has influenced biomarker discovery and the advancement of a next ge

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Markova, E. Y., A. O. Davydov, A. E. Nikitina, M. R. Taevere, and I. G. Osokin. "Pediatric uveitis: modern approaches to anterior segment diagnostics of the eye." Russian ophthalmology of children 51, no. 1 (2025): 37–43. https://doi.org/10.25276/2307-6658-2025-1-37-43.

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Purpose. To present routine and additional methods of examining the anterior segment of the eye for optimal diagnostics of uveitis in children. Material and methods. We performed the search and analysis of scientific publications in the abstract databases PubMed, Scopus and eLibrary for the period up to September 2023. Results. Ophthalmological diagnostic methods are rapidly developing, which allows to visualize altered eye structures and to quantify the degree and dynamics of eye inflammation. Conclusion. Development of anterior segment imaging technologies has increased the accuracy of uveit

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Girmenia, Corrado. "Microbiological diagnostics of fungal infections." Reviews in Health Care 4, no. 1S (2013): 33–37. http://dx.doi.org/10.7175/rhc.v4i1s.862.

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Laboratory tests for the detection of fungal infections are easy to perform. The main obstacle to a correct diagnosis is the correlation between the laboratory findings and the clinical diagnosis. Among pediatric patients, the most common fungal pathogen is Candida. The detection of fungal colonization may be performed through the use of chromogenic culture media, which allows also the identification of Candida subspecies, from which pathogenicity depends. In neonatology, thistest often drives the decision to begin a empiric therapy; in this regard, a close cooperation between microbiologists

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Tsiroulnikova, O. M., I. V. Zhilkin, and D. G. Akhaladze. "CLINICAL SIGNIFICANCE OF CYTOMEGALOVIRUS INFECTION IN PEDIATRIC LIVER TRANSPLANT RECIPIENTS." Russian Journal of Transplantology and Artificial Organs 18, no. 1 (2016): 67–77. http://dx.doi.org/10.15825/1995-1191-2016-1-67-77.

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Liver transplantation is a life-saving procedure for many forms of end-stage liver disease in pediatrics. Cytomegalovirus (CMV) is the most common and signifi cant posttransplant infection after pediatric liver transplant (PLT) with developing an episode of CMV infection or disease. It is well known that CMV increases risk of graft loss. The review presents aspects of etiology and epidemiology of CMV after PLT, approaches employed in diagnostics and prophylaxis of CMV, algorithms for valganciclovir dosing and methods to prevent complications associated with CMV. The latest data on current prev

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Krotov, Ivan, Oleg Konovalov, Rimma Terletskaya, Sergey Zhukov, and Artem Morozov. "A SURVEY ON WORKING ENVIRONMENT, PERFORMANCE AND SATISFACTION AMONG PEDIATRIC SONOGRAPHERS IN RUSSIA: FINDINGS AND DISCUSSION." Archiv Euromedica 11, no. 3 (2021): 5–8. http://dx.doi.org/10.35630/2199-885x/2021/11/3/1.

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Conducting of sociological investigation is an important condition for the implementing effective and targeted health policy. However, such studies, regarding ultrasonic diagnostics specialists are not enough. The article deals with analysis of results of the survey of ultrasonic diagnostic specialists on the issue of evaluation the quality of services provided for ultrasound diagnostics. Among the main factors affecting the quality of ultrasound diagnostics in Russia, doctors’ workload and inadequate material and technical base were often noted. Surveys of specialists allow to identify proble

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Koudijs, Marco J., Lennart A. Kester, Jayne Y. Hehir-Kwa, et al. "RNA-Sequencing Improves Diagnostics and Treatment of Pediatric Hematological Malignancies." Blood 138, Supplement 1 (2021): 107. http://dx.doi.org/10.1182/blood-2021-147692.

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Abstract Background Diagnosis and treatment of hematological malignancies relies increasingly on the detection of underlying genetic abnormalities. Various laboratory techniques, including karyotyping, SNP-array, FISH, MLPA and RT-PCR are typically required to detect the full spectrum of clinically relevant genetic aberrations. These techniques are also hampered in their sensitivity by their targeted approach or lack of resolution. Ideally, an unbiased genome wide approach like RNA sequencing (RNA-seq) as a one-test-fits-all, could save costs and efforts and streamline diagnostic procedures. I

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PIKUSA, O. I., and E. A. SAMORODNOVA. "Lymphadenopathies in pediatric practice." Practical medicine 18, no. 6 (2020): 63–68. http://dx.doi.org/10.32000/2072-1757-2020-6-63-68.

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The purpose — to present the information on the main causes of lymphadenopathies in children and the stages of differential-diagnostic search which complicate diagnosing and determining the treatment tactics. Material and methods. Analysis of literature data on lymphadenopathies in children, features of clinical manifestations under tumorous and non-tumorous etiology of the disease, and approaches to differential diagnostics. Results. The article presents the general information on etiology and classification of the characteristic clinical symptoms of lymphadenopathies in children, which are n

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Bocharov, R. V., Ya V. Shikunova, G. V. Slyzovsky, V. G. Pogorelko, M. A. Zykova, and A. B. Yushmanova. "Trichobezoars in the practice of a pediatric surgeon." Russian Journal of Pediatric Surgery 25, no. 2 (2021): 135–39. http://dx.doi.org/10.18821/1560-9510-2021-25-2-135-139.

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Material and methods. A retrospective analysis of medical records of two children. Anamnestic, clinical, diagnostic and intraoperative findings were analyzed.Purpose. To describe cases of trichobezoars in children : occurrence, diagnostics and treatment.Results. In the first case, a girl, aged 5, often swallowed her own hair after a psychological trauma; and at the age of 15 she complained of hair loss and anemia. In the second case, a boy was chewing and swallowing his own hair for 6 months under the emotional stress. Two weeks before hospitalization he complained of abdominal pain. In both c

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Gaouzi, Zainab, Aziza Belkhayat, Zahra Chebihi Takki, Hind Lachraf, Idrissa Diawara, and Yamna Kriouile. "Unraveling genetic etiologies in complex pediatric neurological diseases: A genetic investigation using whole exome sequencing." PLOS One 20, no. 5 (2025): e0324177. https://doi.org/10.1371/journal.pone.0324177.

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Pediatric neurological disorders are a diverse group of conditions affecting the nervous system in children, often challenging to diagnose due to their nonspecific and overlapping clinical features. Advances in molecular diagnostics, particularly whole exome sequencing (WES), have significantly improved the identification of genetic causes, enabling precise diagnoses and personalized treatments. This study explores the application of WES in diagnosing pediatric neurological disorders within Moroccan childrens with undiagnosed or challenging pediatric neurological conditions to uncover genetic

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Akhaladze, D. G., G. S. Rabaev, and N. S. Grachev. "Technical features cytoreductive surgery and hyperthermic intraperitoneal chemotherapy." Pediatric Hematology/Oncology and Immunopathology 19, no. 4 (2020): 224–33. http://dx.doi.org/10.24287/1726-1708-2020-19-4-224-233.

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In recent years сytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) became popular in pediatric oncologic surgery. This procedure is a “treatment of choice” for determined groups of adult patients. The approaches for preoperative diagnostics and surgical technique are well described in adult patients, but not for pediatric surgery, considering limited experience in сytoreductive surgery and HIPEC in children. This review summarizes literature datas of tumor dissemination, diagnostics and technical features in peritonectomy based on tumor localization and analysis of po

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Xu, Guangxi. "Genetic Diagnostics for Pediatric Hereditary Diseases: Exploring Chromosomal Karyotyping, Single Gene Mutation Screening, and Emerging Technologies." Journal of Innovations in Medical Research 2, no. 8 (2023): 42–50. http://dx.doi.org/10.56397/jimr/2023.08.06.

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This article comprehensively explores genetic diagnostic methods for pediatric hereditary diseases, focusing on chromosomal karyotyping, single gene mutation screening, and emerging technologies. It examines the significance of accurate genetic diagnosis in pediatric cases and emphasizes the role of genetic diagnostic methods in unraveling the underlying molecular basis of these diseases. The article discusses the principles, clinical applications, and case studies of chromosomal karyotyping and single gene mutation screening. It also delves into the ethical considerations and the crucial role

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Pashchenko, I. V., and O. G. Ivanko. "Ernst Moro: returning the names." CHILD`S HEALTH 16, no. 7 (2022): 495–97. http://dx.doi.org/10.22141/2224-0551.16.7.2021.244582.

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The purpose of the publication is an invitation to honor the outstanding pediatrician Ernst Moro (1874–1951), with an attempt to return his pronunciation of the surname by emphasizing the first syllable (Móro), to recall the life and creative career of this outstanding scientist and doctor. The Moro reflex described in 1918 is now widely used by modern pediatricians and pediatric neurologists in everyday practice. Ernst Moro’s scientific achievements in the development of a skin test for tuberculosis diagnostics, the organization of the efforts against diarrhea in young children, and the forma

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Lobova, Olena V., Iryna V. Avramenko, and Iryna I. Shpak. "COVID-19 associated anosmia in pediatric patients: subject publications review." Wiadomości Lekarskie 77, no. 1 (2024): 114–19. http://dx.doi.org/10.36740/wlek202401114.

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Aim: To review the publications subject to the problem of COVID-19 associated anosmia incidence in pediatric patients as well as its pathogenesis, diagnostics, treatment and recovery. The peculiarity of pediatric COVID-19 anosmia is due to children accounting for very low percentage of COVID-19 patients (comparing to one in adults), mostly with milder course of the disease. Awareness of anosmia and its proper diagnostics is crucial in children and adolescents, considering it can be the only manifestation in COVID-19 positive pediatric patients. Materials and Methods: In order to achieve this g

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Bohn, Mary Kathryn, Giulia F. Fabiano, and Khosrow Adeli. "Electronic tools in clinical laboratory diagnostics: key examples, limitations, and value in laboratory medicine." Journal of Laboratory Medicine 45, no. 6 (2021): 319–24. http://dx.doi.org/10.1515/labmed-2021-0114.

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Abstract Electronic tools in clinical laboratory diagnostics can assist laboratory professionals, clinicians, and patients in medical diagnostic management and laboratory test interpretation. With increasing implementation of electronic health records (EHRs) and laboratory information systems worldwide, there is increasing demand for well-designed and evidence-based electronic resources. Both complex data-driven and simple interpretative electronic healthcare tools are currently available to improve the integration of clinical and laboratory information towards a more patient-centered approach

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Bot, Maria N., Hedwig A. van der Meer, Marloes Meurs de Vries, Ewald M. Bronkhorst, Stanimira I. Kalaykova, and Nico H. J. Creugers. "Diagnostics and Management of Pediatric Headache: An Exploratory Study among Dutch Physical Therapists." Children 10, no. 7 (2023): 1135. http://dx.doi.org/10.3390/children10071135.

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Physiotherapists are often part of a multidisciplinary treatment plan for children with headaches. The literature on physical therapeutic diagnostics and management of headaches is often focused on adults. To gain insight, identify knowledge gaps, and increase the evidence needed for clinical physical therapeutic practice with children with headaches, an exploratory method is warranted. The purpose of this study was to describe the views, beliefs, and experiences of physical therapists regarding diagnostics and treatment options for children with headaches. The method consisted of a survey and

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Aghakhanyan, Gayane, Tommaso Filidei, Maria Febi, et al. "Advancing Pediatric Sarcomas through Radiomics: A Systematic Review and Prospective Assessment Using Radiomics Quality Score (RQS) and Methodological Radiomics Score (METRICS)." Diagnostics 14, no. 8 (2024): 832. http://dx.doi.org/10.3390/diagnostics14080832.

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Pediatric sarcomas, rare malignancies of mesenchymal origin, pose diagnostic and therapeutic challenges. In this review, we explore the role of radiomics in reshaping our understanding of pediatric sarcomas, emphasizing methodological considerations and applications such as diagnostics and predictive modeling. A systematic review conducted up to November 2023 identified 72 papers on radiomics analysis in pediatric sarcoma from PubMed/MEDLINE, Web of Knowledge, and Scopus. Following inclusion and exclusion criteria, 10 reports were included in this review. The studies, predominantly retrospecti

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Ecker, Jonas, Florian Selt, Dominik Sturm, et al. "OTHR-32. The Pediatric Targeted Therapy 2.0 registry: robust molecular diagnostics for precision oncology." Neuro-Oncology 24, Supplement_1 (2022): i154. http://dx.doi.org/10.1093/neuonc/noac079.570.

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Abstract BACKGROUND: The Pediatric Targeted Therapy (PTT) 2.0 program was established to enable precision oncology for relapsed pediatric oncology patients by performing a set of molecular analyses on tumor samples to improve diagnostic accuracy and to detect actionable alterations. METHODS: International pediatric oncology patients with relapse or progression after standard of care treatment independent of histological diagnosis were included. Required material was an FFPE sample from any disease episode available to perform a DNA methylation array, customized targeted gene panel sequencing (

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Kalinina, N. M., E. G. Furman, and V. L. Sokolovskiy. "Diagnostics of bronchial obstruction syndrome with portal wheezing detector in children." Perm Medical Journal 39, no. 2 (2022): 86–92. http://dx.doi.org/10.17816/pmj39286-92.

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Objective. To determine the efficiency of diagnostics of the clinical syndrome of bronchial obstruction with WheezeScan detector in children, to assess the sensitivity and specificity of this method. Electronic medical devices used for registration and analysis of breath sounds can help to diagnose different syndromes in pediatric pulmonology. Materials and methods. The study involved 15 children aged 1 to 17 years, who were hospitalized to Pulmonology Unit of the Regional Childrens Clinical Hospital. The children were divided into two groups depending on the presence or absence of wheez

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Pykov, M. I., and Anastasia M. Vrublevskaya. "ECHOGRAPHY IN THE DIAGNOSTICS OF INFLAMMATORY BOWEL DISEASES IN CHILDREN." Russian Journal of Pediatric Surgery 24, no. 2 (2020): 101–7. http://dx.doi.org/10.18821/1560-9510-2020-24-2-101-107.

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Crohn’s disease (CD) and ulcerative colitis (UC) are pathologies that have various clinical manifestations, which sometimes cause problems in putting a correct diagnosis by clinicians. The review of domestic and foreign literature highlighted the relevance in improving the diagnostics of inflammatory bowel disease (IBD). Modern diagnostic techniques (computed tomography, magnetic resonance imaging, various endoscopic and radiological methods) are widespread in clinical practice, but they have a number of limitations in pediatric practice and are associated with certain risks. Significant drawb

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Simtoco, Michie Jay D., Samantha Soriano–Castaneda, Daniel M. Alonzo, and Maria Rina T. Reyes-Quintos. "Fractured Tracheostomy Tube Ingestion in a Pediatric Patient." Philippine Journal of Otolaryngology-Head and Neck Surgery 24, no. 1 (2009): 18–20. http://dx.doi.org/10.32412/pjohns.v24i1.707.

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Objective: To report a case of fractured tracheotomy tube ingestion in a pediatric patient, discussing the clinical presentation, complications and management of tracheobronchial tree versus upper digestive tract foreign bodies.  Method:  Design: Case Report Setting: Tertiary Private Hospital  Subject: One  Results: A 4-year-old male child with unusual hypersensitivity to routine tracheotomy suctioning was discovered to have a fractured tracheotomy tube. Emergency radiographs localized the cannula in the abdomen and bronchoscopy was deferred. The forei

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Orlova, E. M. "Federal clinical recommendations on diagnostics and treatment of hypoparathyroidism in the children and adolescents." Problems of Endocrinology 60, no. 3 (2014): 69–74. http://dx.doi.org/10.14341/probl201460369-74.

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Hypoparathyroidism is a rare etiologically heterogeneous condition that manifests itself in the children in the first place as hypocalcemia. The purely hypocalcemic convulsions are usually interpreted as manifestations of epilepsy which leads to the prescription of an inadequate treatment. The early diagnostics and correct therapy ensure the normal development and social adaptation of the affected child. The present clinical guidelines developed at the Institute of Pediatric Endocrinology, Endocrinological Research Centre, highlight the diagnostic problems pertaining to hypoparathyroidism, as

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Kovalchuk, P. V., O. V. Katilov, and S. O. Panenko. "Modern approaches to diagnostics and treatment of migraine in children." Pain medicine 3, no. 4 (2019): 41–53. http://dx.doi.org/10.31636/pmjua.v3i4.2.

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This article reviews modern approaches to diagnostics and treatment of a very common and simultaneously underestimated and often maltreated disorder in children. It is fallacious management of migraine masked behind the diagnoses such as autonomic vessel dysfunction and vascular headache here in Ukraine. This is a tremendous problem and it should be solved with appropriate information spread across the medical community. Up-to-date classification according to the International Headache Society, diagnostic criteria, differential diagnosis, investigation and treatment strategies are presen

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Bächli, Heidi, Jonas Ecker, Cornelis van Tilburg, et al. "Molecular Diagnostics in Pediatric Brain Tumors: Impact on Diagnosis and Clinical Decision-Making — A Selected Case Series." Klinische Pädiatrie 230, no. 06 (2018): 305–13. http://dx.doi.org/10.1055/a-0637-9653.

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AbstractCentral nervous system (CNS) tumors account for the highest mortality among pediatric malignancies. Accurate diagnosis is essential for optimal clinical management. The increasing use of molecular diagnostics has opened up novel possibilities for more precise classification of CNS tumors. We here report a single-institutional collection of pediatric CNS tumor cases that underwent a refinement or a change of diagnosis after completion of molecular analysis that affected clinical decision-making including the application of molecularly informed targeted therapies. 13 pediatric CNS tumors

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Ortega MD, Hector I., and Anna L. Gloyn, DPhil. "Precision Diagnostics for Monogenic Diabetes in Children." SMART-MD Journal of Precision Medicine 2, no. 2 (2025): e119-e128. https://doi.org/10.69734/1e8v6h36.

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Monogenic diabetes, caused by a single-gene defect, accounts for roughly 1–5% of pediatric diabetes cases. Although relatively uncommon, correct identification of these subtypes is critical, as accurate classification can markedly influence both treatment and prognosis. However, distinguishing monogenic forms from type 1 (T1D) or type 2 diabetes (T2D) remains challenging due to overlapping features, such as early onset and variable insulin requirements. Many children with monogenic diabetes are misdiagnosed and, consequently, may not receive optimal therapy. Advances in sequencing technologies

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Shelton, Althea Robinson. "Sleep Disorders in Childhood." CONTINUUM: Lifelong Learning in Neurology 29, no. 4 (2023): 1205–33. http://dx.doi.org/10.1212/con.0000000000001285.

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ABSTRACT OBJECTIVE This article provides a comprehensive review of pediatric sleep disorders including the clinical features, diagnosis, and treatment of sleep-disordered breathing, insomnia, parasomnias, restless sleep disorder, restless legs syndrome, narcolepsy in childhood, and Kleine-Levin syndrome. LATEST DEVELOPMENTS Our understanding of pediatric sleep pathophysiology continues to evolve, and diagnostic and treatment modalities have expanded. A low-sodium oxybate formulation was approved in July 2020 in the United States to treat cataplexy and excessive daytime sleepiness in patients 7

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Miklja, Zachary, Amy Pasternak, Stefanie Stallard, et al. "Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations." Neuro-Oncology 21, no. 8 (2019): 968–80. http://dx.doi.org/10.1093/neuonc/noz022.

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Abstract As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for childre

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Iakovleva, Ekaterina S., Vladimir V. Lazarev, and Andrey V. Diordiev. "Role of an anesthesiologist in pediatric X-ray diagnostics." Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care 9, no. 2 (2019): 97–104. http://dx.doi.org/10.30946/2219-4061-2019-9-2-97-104.

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Purpose: analysis of modern data devoted to the issue of stress-free and safe magnetic resonance imaging in children using both non-drug methods and different agents for anesthesia along with their delivery systems.Discussion. It is difficult to complete MRI in younger children due to some reasons and possible development of stress. The technique often requires the presence of an anesthesiologist, especially if patients present with neurological pathology. The article describes how to deal with this problem to ensure safety and comfort during the procedure at the X-ray diagnostic department.Co

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Schmoch, Thomas, Jens H. Westhoff, Sebastian O. Decker, et al. "Next-generation sequencing diagnostics of bacteremia in pediatric sepsis." Medicine 100, no. 25 (2021): e26403. http://dx.doi.org/10.1097/md.0000000000026403.

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Prikhodina, L. S. "Clinical integration of genetic diagnostics to pediatric nephrology. Review." Nephrology and Dialysis 22, no. 3 (2020): 293–311. http://dx.doi.org/10.28996/2618-9801-2020-3-293-311.

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