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Dissertations / Theses on the topic 'PEG-PCL'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Vasconcelos, Juliana de Almeida Pachioni. "Desenvolvimento de vesículas poliméricas de poli(etileno glicol)-b-poli(ε-caprolactona) (PEG-PCL) para veiculação de L-asparaginase." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-26072018-154155/.

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A L-Asparaginase (ASNase) é um importante agente quimioterapêutico utilizado para o tratamento da leucemia linfoblástica aguda (ALL) há mais de 40 anos. No entanto, devido à origem biológica da ASNase, enzima produzida por Escherichia coli, problemas como a imunogenicidade e baixa meia vida-plasmática devem ser considerados. Com o objetivo de minimizar essas desvantagens, várias ASNases homólogas bem como formulações de ASNase de E. coli foram investigadas. Nenhuma das formulações desenvolvidas, entretanto, foi capaz de resolver definitivamente esses problemas associados à sua origem. Nesse se

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2

Endres, Thomas [Verfasser], and Thomas [Akademischer Betreuer] Kissel. "Biodegradable amphiphilic PEG-PCL-PEI triblock copolymers designed for the self-assembly of multifunctional gene carriers / Thomas Endres. Betreuer: Thomas Kissel." Marburg : Philipps-Universität Marburg, 2013. http://d-nb.info/103231396X/34.

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RODRIGUES, KIRIAKI M. S. "Influência de polietilenoglicol (PEG) na liberação modificada de teofilina em comprimidos de poli-3-midroxibutirato (PHB) e poli-e-caprolactona (PCL)." reponame:Repositório Institucional do IPEN, 2008. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10155.

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Made available in DSpace on 2014-10-09T12:35:24Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:05:36Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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4

Zhu, Xiaobo. "DESIGN AND SYNTHESIS OF BLOCK COPOLYMERS THAT SELF ASSEMBLE INTO MICELLES WITH CONTROLLED ACID AND LIPASE CATALYZED DEGRADATION." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/250374.

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Chemistry<br>Ph.D.<br>Poly (ε-caprolactone) block poly (ethylene glycol) (PCL-b-PEG) is typical amphiphilic block copolymer that self assembles into micelles in water where the hydrolytically stable hydrophilic PEG segment forms the exterior corona and the core contains the hydrophobic degradable PCL block. Micelles from PCL-b-PEG block copolymers are among the top candidates for application as transport and delivery systems. The efficiency for micellar transported therapeutics to reach the desired site is currently limited by processes that prematurely degrade the micelle and this issue

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Montenegro-Galindo, Gladys Rocio. "Synthesis and Protein Adsorption Studies of Pegylated-Polyester Nanoparticles with Different Peg Architectures." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1384629996.

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6

Satyal, Uttam. "Efficient Drug and Nucleic Acid Delivery Systems based on Synthetic Amphiphiles with Tuned Oil/Water Interfaces." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/531985.

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Pharmaceutical Sciences<br>Ph.D.<br>Today, drugs are an integral part of healthy human life, with new drug entities being introduced every year in clinic. The advancement of drug development brings complexity and variation, in terms of both physical and chemical properties. Some of these physicochemical characteristics are many times suboptimal, eventually requiring robust delivery systems that can precisely deliver the drugs to the desired tissues. Although many materials have been studied for the generation of drug delivery systems, there is always a need for biomaterials with better propert

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Gontard, Gwenaëlle. "Synthèse de nanoconjugués PEG-PLA pour des applications biomédicales : libération contrôlée et Imagerie." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30279.

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Ce travail de thèse s’inscrit dans le cadre d’une collaboration entre Sanofi à Vitry-sur-Seine et le Laboratoire Hétérochimie Fondamentale et Appliquée (LHFA) à Toulouse, et a pour but de développer de nouveaux nanovecteurs à base de conjugués polymériques biodégradables et biocompatibles capables d’encapsuler, de transporter et de libérer des agents thérapeutiques. Les travaux précédemment réalisés au laboratoire, ont montré que la libération de principes actifs hydrophobes, tels que le Cabazitaxel de la famille des taxanes, pouvait être contrôlée grâce à l’architecture de conjugués de nature

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Castano, Gil Yenni Marcela. "Green Polymer Chemistry: The Role of Candida Antarctica Lipase B in Polymer Functionalization." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1398034236.

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9

Yen, Chi. "Synthesis and Surface Modification of Nanoporous Poly(ε-caprolactone) Membrane for Biomedical Applications". The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1268074499.

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10

Fidalgo, Andreia Filipa Teixeira. "Otimização da síntese de copolímeros PCL/PEG." Master's thesis, 2017. http://hdl.handle.net/10316/82931.

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Dissertação de Mestrado Integrado em Engenharia Química apresentada à Faculdade de Ciências e Tecnologia<br>Na sociedade atual são múltiplos os problemas associados à visão, como a cataratas e o glaucoma. Ao longo dos anos, tem sido desenvolvida investigação em prol da qualidade de vida do Homem, nomeadamente no sentido de melhorar o tratamento e acompanhamento de casos clínicos. Porém, o maior desafio no tratamento das doenças oculares persiste. A capacidade de manutenção do nível terapêutico do fármaco no local de ação, durante o período de tempo necessário, continua a ser uma das dificuldad

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11

Chen, Kuan-chou, and 陳冠州. "Synthesis and properties of polyurethane microcapsule with PCL-PEG-PCL triblock copolymer." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/5tb6d4.

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碩士<br>國立臺灣科技大學<br>高分子系<br>94<br>In this study, first, we synthesized the triblock ester-ether copolydiol (PCL-PEG-PCL) presenting hydrophilic and hydrophobic properties. Secondary, the polyurethane (PU) microcapsule content Lavender oil is produced by interfacial polycondensation and varied the composition of the triblock ester-ether copolydiol as the soft segment；Namely, change the PEG molecular weight and CL/PEG molar ratio. The different kinds of hard segment are used and varying the NCO/OH molar ratio, Diethlenetriamine (DETA) is employed as the chain extender. We discuss the relationship

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12

Liou-Huang, Siang, and 劉黃翔. "Controllable degradation properties of photocrosslinked PLA-b-PEG-b-PLA / PCL-b-PEG-b-PCL complex hydrogels for cell delivery." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/62436049711836799133.

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碩士<br>國立清華大學<br>化學工程學系<br>101<br>Due to the cartilage’s poor self-repairing capacity, cartilage repairs have become a growing concern. Tissue engineering has been proposed as an alternative method to repair diseased cartilage. Tissue engineering consists of cells and a biodegradable scaffold, the latter provides a suitable environment for tissue repairs and regeneration. Hydrogel scaffolds are three-dimensional in structure and are promising substrates for tissue engineering applications due to their high water content, efficient mass transfer, and ability to homogenously encapsulate cells. In

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Ko, Chao Yin, and 柯朝寅. "Photo-crosslinked PCL-PEG-PCL hydrogels as cell carrier for cartilage tissue engineering." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/78060632842458065426.

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博士<br>國立清華大學<br>化學工程學系<br>102<br>Osteoarthritis (OA) is a common type of degenerative arthritis marked by the thinning of the articular cartilage and affects sedentary or older individuals in general. Owing to the absence of blood vessels and cells, articular cartilage has very limited self-regeneration capacity following injury. Current methods to repair articular hyaline cartilage often lead to fibrocartilage formation, which is inferior for the application intended. Therefore, tissue engineering methods have been considered for cartilage repair and restoration. Injectable hydrogels are attr

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14

Chang, Huan-Hsun, and 張桓熏. "The study of biodegradable PCL /starch and PEG/starch." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/kjvw53.

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碩士<br>國立臺北科技大學<br>化學工程研究所<br>98<br>This research investigates the changes of polymer blends of Preparedpolycaprolactone (PLC) or Polyethylene glycol (PEG) and thermoplastic stach(TPS) in the thermal properties after the processing. By the Differential Scanning Calorimetry(DSC) observation Polymer blends thermal property change, we draw to the conclusion that Polyethylene glycol (PEG) and blending of the plasticized starch (TPS) has the melting peak at 55 ℃. The blends of Polycaprolactone (PLC) and thermoplastic starch (TPS) of have melting peaks at 64 ℃. Through the MFI test, we presume that w

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Ning, Sin-Tzu, and 寗欣慈. "CD133-targeted SN38 mPEG-PCL/mal-PEG-PCL micelles for human colorectal cancer stem cell therapy." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/35974076911061790222.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>102<br>Cancer stem-like cells play key role in tumor development and these cells is relevant to the failure of conventional chemotherapy. To achieve a favorable therapy of colorectal cancer, amphiphilic polymer ethylene-glycol-ε-caprolactone (mPEG-PCL) and maleimide-ethylene-glycol-ε-caprolactone (mal-PEG-PCL) is fabricated and may self-assemble to form micelle which possesses well biological compatibility as a topoisomerases inhibitor, SN38 nanocarrier. For cancer stem cell therapy, CD133 (prominin-1) is a putative cancer stem-like cells (CSLCs) maker for colorecta

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Tseng, Chun-Yuan, and 曾俊元. "Fabrication of Photo-polymerized PCL-PEG-PCL Three-dimensional Scaffolds by Dynamic Mask Rapid Prototyping System." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/38453127291877783155.

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碩士<br>國立臺灣科技大學<br>機械工程系<br>96<br>In the previous Dynamic Mask Rapid Prototyping System developed in our laboratory, PCL-PEG-PCL was mixed with PEG-HEMA in chloroform and cured to create scaffolds successfully. However, the solubility of PEG-HEMA in chloroform is still an issue to be improved. Besides, the old system could not create scaffolds more than 5 layers without pore closure. Therefore, in this research, PEG-HEMA synthesis and the system were improved. Moreover, thicker and more precise 3D scaffolds were fabricated. In PEG-HEMA synthesis, 98% HEMA was used to replace 96% HEMA. The new P

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Chang, Keng-Lun, and 張耕綸. "Effect of Lauric Acid-loaded PCL-PEG-PCL Nano-sized Micelles on the Activity ofPropionibacterium Acnes." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/62489871140981028538.

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碩士<br>中原大學<br>奈米科技碩士學位學程<br>98<br>Acne vulgaris is known as infection of pathogenic bacteria, Propionibacterium acnes (P. acnes). Lauric acid (LA) was found to kill P. acnes effectively. However, LA is a sparingly soluble fatty acid in water in which dimethly sulfoxide (DMSO) is used to increase solubility. In this study, amphiphilic micelles encapsulating LA was developed to reduce DMSO-induced toxicity and improve bactericidal effect of LA. Poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) triblock copolymer was sythysized by ring-opening polymerization. Different

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18

Jiang, Jian-Lin, and 江建霖. "Inhibition Effect of Doxorubicin-loaded PEG-PCL-PEG on the Human Breast Cancer Using a Xenograft Model of Nude Mice." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/75056204011812141582.

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碩士<br>中原大學<br>醫學工程研究所<br>98<br>In this study, the biodegradable poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG) for the nano-sized micelles synthesized. The in vitro hemolysis test showed that the micelles which concentrations of 2.0 mg/mL or less had good blood biocompatibility. The in vitro experiment of acute toxicity using empty micelles (placebo) at dosage of 71.43 mg/kg showed no apparent change of body weight in mice, and the survival rate was 100 %. Furthermore, in the tissue slices of liver and kidney, the cell morphology was normal. And there was unobvi

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Lee, Siou Ting, and 李綉婷. "Application at Drug-Containing PCL/PEG Nanofibrous Membranes in Post-Surgical Anti-Adhesion." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/70845321161362970262.

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碩士<br>長庚大學<br>化工與材料工程學系<br>101<br>Electro-spinning technology, has also often used in the field of biomedical engineering, nano fiber membrane made of it has holes, the tiny holes can allow nutrients and waste pass through and prevents tissue ingrowth that effectively form a barrier, Therefore, this study uses polycaprolactone, it has good biocompatibility and biodegradability properties, polyethylene glycol is added to enhance the ductility and hydrophilicity, produce polycaprolactone/ polyethylene glycol (PECL) nano fiber membrane, and add two drugs, Amoxicillin and Ibuprofen, to evaluate it

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Galvão, Ana Catarina Simões das Neves. "Desenvolvimento de insertos oculares para tratamento de glaucoma." Master's thesis, 2019. http://hdl.handle.net/10316/87867.

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Dissertação de Mestrado Integrado em Engenharia Biomédica apresentada à Faculdade de Ciências e Tecnologia<br>O glaucoma é uma doença crónica e assintomática que afeta cerca de 60 milhões de pessoas em todo o mundo. A administração incorreta das gotas e a deteção tardia da doença pode, muitas vezes, tornar irreversível a perda de visão.De forma a colmatar este problema, foi desenvolvido um inserto ocular, registado como ineye®, que permite a libertação de um ou mais fármacos de forma controlada durante um tempo determinado. Este inserto deve possuir algumas características, tais como, ser inso

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Jung, Lin Din, and 林定宗. "Synthesis of PCL-PEG-PCL Triblock Copolydiol Base Polyurethane and Their Applications of Water Vapor Permeability and Water Resistence on Nylon Fabrics." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/49465018537979125783.

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Sun, Kai-min, and 孫凱閔. "Combine PCL and PEG-acrylate to Fabricate Three-dimensional Scaffolds by Dynamic Mask Rapid Prototyping System." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/d84pfj.

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碩士<br>國立臺灣科技大學<br>機械工程系<br>99<br>In the previous research in our laboratory, the photo-curable PCL, mixing with photo-initiator, was dissolved in the acetone and photo-polymerized to fabricate tissue engineering scaffolds by a Dynamic Masking Rapid Prototyping System. However, without cross-linking binders, the strength of the cured PCL is not satisfying. Therefore, in this research, commercially available PEG- acrylate was adopted as binder in the material system to improve the strength, the Dynamic Masking RP system was modified for the material to reach better process accuracy, and 3D porou

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CHEN, FREEMAN, and 陳定閒. "Research on Combining Photo-curable PCL with PEG-diacrylate and Chitosan to Fabricate Tissue Engineering Scaffold." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/68306235285940594431.

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碩士<br>國立臺灣科技大學<br>機械工程系<br>102<br>Tissue Engineering combines the principles and methods of engineering and life science to develop biological substitutes to restore, maintain and improve human tissue functions. Scaffold is one of the three key elements in Tissue Engineering. Layered manufacturing techniques, also known as Additive manufacturing (AM) processes, provide a great opportunity to fabricate 3D scaffolds without problems such as limited control of pore-size and restricted geometric shapes in traditional methods. The Biomedical Maskless Rapid Prototyping System developed in our previo

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Wei, Ting-yu, and 魏廷宇. "Study on improving the accuracy of photo-cured PCL-DA/PEG-DA scaffold by coloring the material." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/e4gkfw.

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碩士<br>國立臺灣科技大學<br>機械工程系<br>104<br>Tissue engineering scaffolds of PCL-DA and PEG-DA will have the over-curing problem when encountering light transmission, because their transparent materials have the feature of optical transmittance. Also, the usage of acetone leads to shrinking problems of photocuring scaffolds. The previous studies have shown that method of scaffold dyeing can improve the problem of light transmission. Therefore, this paper tries to use non-toxic dyes and pigments to replace the original ink dye for the application to fabricate tissue engineering scaffolds, as well as to de

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HOU, JIA-YAN, and 侯佳延. "Combine PCL and PEG-diacrylate to Fabricate 3D Tissue Engineering Scaffolds by Reflective Dynamic Masking Rapid Prototyping System." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/81698675160763609225.

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碩士<br>國立臺灣科技大學<br>機械工程系<br>100<br>In our previous research, photo-curable PCL (PCL-DA), mixing with PEG-acrylate as a binder and photo-initiator, was photo-polymerized to fabricate tissue engineering scaffolds by a direct Dynamic Masking Rapid Prototyping (DMRP) system. The strong photo-sensitivity of the material system led pores closed in the scaffolds after stacking three layers. Therefore, in this research, a reflective DMRP system was established to improve the above issue. Moreover, PEG-diacrylate (PEG-DA) was used to replace PEG-acrylate to increase the strength of the cured materials.

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Fernandes, Carla Patricia Cravid. "Otimização do processo de fabricação e semeação de scaffolds de PCL/gelatina anisotrópicos para a engenharia de cartilagem." Master's thesis, 2018. http://hdl.handle.net/10773/25152.

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O tratamento de lesões da cartilagem articular constitui um desafio para a medicina regenerativa. Nesse âmbito, a engenharia de tecidos tem-se debruçado sobre o desenvolvimento de métodos que visam alcançar resultados mais aprimorados. Para tal, são várias as abordagens possíveis, destacando-se por exemplo, o método de semeação de células em estruturas tridimensionais porosas (scaffolds). Com este trabalho pretendeu-se otimizar o processo de fabricação e de semeação de células em scaffolds. As técnicas de semeação selecionadas (compressão, top and bottom e injeção) para o estudo foram desenvo

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Ku, Kian-Lin, and 古莞霖. "Co-culture of Encapsulated Mesenchymal Stem Cells and Chondrocytes in PEG/PCL Photocrosslinked Hydrogel Scaffolds for Cartilage Tissue Engineering." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/00052700392429419545.

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碩士<br>國立清華大學<br>化學工程學系<br>100<br>The U.S. costs 128 million per year due to arthritis disease currently. With the aging and obesity, osteoarthritis patients have increased. Cartilage lacks blood vessels and lymphatic tissue, its ability to repair itself doesn’t like other tissue. According to the concept of tissue engineering, the cells were transplanted to the suitable scaffolds, to replace the damaged parts of the original by regenerative tissue. In recent year, hydrogels have been used as scaffolds for cartilage tissue regeneration, partly for their high water content that can enhance nutri

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Hsu, Yu-Wei, and 許淯維. "Study on using additive manufacturing technology to fabricate photo-cured PCL- DA+PEG-DA/PGSA scaffold for liver tissue engineering." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/3987q3.

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碩士<br>國立臺灣科技大學<br>機械工程系<br>105<br>Currently, the treatment of liver disease is by organ transplantation, but the risk of surgery and the shortage of liver supplement are still the drawbacks that can’t be overcome. Although utilizing tissue engineering can repair the damaging part of liver directly, but there are still some restricts on material and manufacturing process. So is still hard to fabricate a scaffold like a real liver. This study focuses on this two issue that mentions above. We want to develop a biomaterial that combines with both mechanical strength and biocompatibility, and use d

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Yang, Yu-kai, and 楊淯凱. "Study on Material Properties and Tissue Engineering Scaffold Fabrication Capability of Photo-cured PCL with PEG-diacrylate by Additive Manufacturing Technique." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/qepuqg.

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碩士<br>國立臺灣科技大學<br>機械工程系<br>102<br>Additive Manufacturing (AM) technologies have been applied to fabricate tissue engineering scaffolds nowadays to solve issues such as pore-size control and geometry shapes in traditional methods. Most AM approaches utilize extrusion or sintering, yet few by photo-curing. In the previous research in our lab, preliminary study on photo-curable PCL material (PCL-DA) combining with PEG-diacrylate (PEG-DA) cured by Dynamic Masking Rapid Prototyping System was conducted, but material properties are not well understood. Besides, the over-curing issue of the material

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Fang, Chih-Hsiang, та 方志翔. "Fused Deposited Manufacturing of Hydroxyapatite-loaded PEG-PCL Scaffolds and TGF-β Loaded Glycidyl Hyaluronic Acids Hydrogel for The Treatment of Osteochondral Defects in Rabbits". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/n3e3xx.

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碩士<br>中原大學<br>生物醫學工程研究所<br>103<br>Osteoarthritis, a musculoskeletal diseases prevailed in the elderly, there is no current threpy for curing osteoarthritis. Tissue engineering is the most protential way to heal the osteoarthritis, nevertheless, to promote the tissue regeneration by using tissue engineering was necessary. A scaffold of biomaterials for tissue regeneration which is well recognized that the internal architecture of the scaffold, namely pore size, shape and interconnectivity, has a strong effect on the biological response of the cells. Recently rapid prototyping has emerged to pro

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