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Dissertations / Theses on the topic 'PET tracer'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Gu, Wei Q. "Automated tracer-independent MRI/PET image registration." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29596.pdf.

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2

Neels, Oliver Christian. "Tracer development for detection and characterization of neuroendocrine tumors with PET." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/306190591.

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3

Moreau, Steven. "Characterizing Rho Kinase Activity Using a Novel PET Tracer in Hypertrophied Cardiomyocytes." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22887.

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Cardiac hypertrophy is a compensatory response to increased work load or stress on the heart, but over time can lead to heart failure and death. The molecular mechanisms underlying this disease are still not completely understood, however the Rho/Rho kinase pathway has been shown to play a role. N-[11C]-methyl-hydroxyfasudil, a PET radiotracer, binds to active Rho kinase and could be a possible tracer for hypertrophy. Hypertrophy was induced in vitro using the β-adrenergic receptor agonist isoproterenol to evaluate optimal Rho kinase activity. Rho kinase activity data was correlated to N-[11C]

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4

Baier, Nina [Verfasser]. "Positronenemissionstomographie neuroendokriner Tumoren: Etablierung eines Mausmodells und Biodistribution ausgewählter PET-Tracer / Nina Baier." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1036925137/34.

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5

Hachem, Maryam. "Characterization of [18F]FPyKYNE-Losartan as a Novel PET Tracer for Imaging AT1 Receptors." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32417.

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The Angiotensin II Type I Receptor (AT1R) is the main receptor that produces most of the physiological actions of the Renin Angiotensin System (RAS). Alterations of AT1R expression in renal and cardiovascular diseases make this receptor an attractive target for developing an imaging agent to monitor its expression in disease states. [18F]FPyKYNE-Losartan has been developed as a derivative of the clinically used AT1R blocker Losartan. The aim of this work was to characterize this tracer and evaluate its potential as an imaging agent for AT1Rs, thereby, progressing towards human imaging of the A

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6

Fredriksson, Anna. "Tracer development and PET studies : labeled proinsulin C-peptide and an EGFR-TK inhibitor /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-191-8.

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7

Heurling, Kerstin. "Characterization of [18F]flutemetamol binding properties : A β-amyloid PET imaging ligand". Doctoral thesis, Uppsala universitet, Radiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-262019.

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The criteria for diagnosing Alzheimer’s disease (AD) have recently been revised to include the use of biomarkers for the in vivo presence of β-amyloid, one of the neuropathological hallmarks of AD. Examples of such biomarkers are positron emission tomography (PET) β-amyloid specific ligands, including [18F]flutemetamol. The aim of this thesis was to characterize the binding properties of [18F]flutemetamol from a tracer kinetic perspective as well as by validating binding measures through comparison with tissue pathology assessments. The applicability of previously developed kinetic models of t

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8

Lundquist, Pinelopi. "Imaging and Quantification of Brain Serotonergic Activity using PET." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6830.

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9

Arksey, Natasha C. "Synthesis and Preliminary Evaluation of an F-18 Labeled Fluoropyridine Losartan Analog as a Novel PET Tracer for Imaging AT1 Receptors." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22803.

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Several cardiac diseases, including hypertrophy, cardiomyopathy, and myocardial infarction, result in the upregulation of cardiac angiotensin II type-1 receptors (AT1R). Imaging the AT1R in vivo via PET provides the potential to monitor disease progression and guide therapy accordingly. The aim of this research was to develop a novel F-18 labeled losartan analog as an AT1R PET tracer and begin evaluation in rats. Due to the longer half-life and shorter positron range of F-18, we presume that an F-18 labeled tracer will be more beneficial than current C-11 labeled tracers. Prior structure-activ

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10

Zacherl, Mathias [Verfasser], and Bruno [Akademischer Betreuer] Huber. "Neuartige PET Tracer zur Gewebecharakterisierung und zum Therapiemonitoring nach Myokardinfarkt im Mausmodell / Mathias Zacherl ; Betreuer: Bruno Huber." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1221524429/34.

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11

Figueiras, Francisca Patuleia 1984. "Dual-tracer molecular neuroimaging : methodological improvements and biomedical applications." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/84176.

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Positron emission tomography (PET) is a functional imaging method that allows studying physiological, biochemical or pharmacological processes in vivo. PET is being used in both research and clinical practice. In the brain, it has been used to investigate metabolism, receptor binding, and alterations in regional blood flow. This thesis involves both preclinical and clinical dual-tracer PET imaging studies of different neurological disorders. In this way, different radiotracers were used along the projects. The first project focused on the implementation and in vivo validation of the simultaneo

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12

Sörensen, Jens. "PET in Heart Failure - Methods and Applications." Doctoral thesis, Uppsala University, Clinical Physiology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4654.

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<p>Positron Emission Tomography (PET) permits regional myocardial perfusion, fibrosis and oxidative metabolism to be non-invasively quantified with radioactive tracers such as [<sup>15</sup>O]-water and [1-<sup>11</sup>C]-acetate. PET is an established research tool in congestive heart failure (CHF), a major cause of morbidity and mortality. However, as CHF is a syndrome that eventually affects all aspects of cardiac and systemic hemodynamic function, more clinically relevant information from a single PET scan is desirable. The aim of this thesis therefore was to develop and implement some new

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13

Fang, Xiaotian T. "Preclinical PET imaging of Alzheimer's disease progression." Doctoral thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333220.

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Amyloid PET imaging with [11C]PIB enabled detection of Aβ for the first time in vivo. However, [11C]PIB is a small molecule that binds only the insoluble Aβ plaque. Rather, the soluble Aβ aggregates are considered the cause of Alzheimer’s disease (AD). As such, a more sensitive and specific PET tracer is needed for tracking longitudinal AD pathology. Soluble Aβ aggregates likely interact with the metabotropic glutamate receptor 5 (mGluR5) to cause neurotoxic effects. However, with [11C]ABP688 PET we were unable to detect aberrant mGluR5 binding in AD mouse models, although we find elevated mGl

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14

Shah, Farah. "Chemical development of radioligands for PET studies of central neurotransmitters in vivo." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314090.

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15

Niu, Zheng [Verfasser], Bernd [Akademischer Betreuer] Reif, Bernd [Gutachter] Reif та Aphrodite [Gutachter] Kapurniotu. "NMR Studies to Characterize Amyloid Inhibitors and Aβ-PET Tracer Complexes / Zheng Niu ; Gutachter: Bernd Reif, Aphrodite Kapurniotu ; Betreuer: Bernd Reif". München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/119244180X/34.

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16

Rodig, Heike. "Charakterisierung von 16alpha-[18F]Fluorestradiol-3,17beta-disulfamat als potentieller Tracer für die Positronen-Emissions-Tomographie." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2002. http://nbn-resolving.de/urn:nbn:de:swb:14-1023210677875-30071.

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In den westlichen Industrieländern ist Brustkrebs die häufigste krebsbedingte Todesursache bei Frauen. Bei der Diagnose von Brustkrebs ist für bestimmte Fragestellungen die Positronen-Emissions-Tomographie (PET) eine wichtige Ergänzung zur Mammographie und Sonographie. Die derzeit eingesetzten PET-Tracer 2-[18F]Fluor-2-desoxy-D-Glucose (FDG) und 16a-[18F]Fluor-17b-estra--diol (FES) können Mammakarzinome bzw. deren Metastasen nicht mit 100%iger Sicherheit nachweisen. Aus diesem Grund wurde eine [18F]-markierte Verbin-dung entwickelt, die möglicherweise die diagnostische Sicherheit bei Brustkreb

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17

OLIVEIRA, RICARDO de S. "Estudo da marcação com Indio-111 e Gálio-68 de derivados da bombesina e avaliação das propriedades biológicas para aplicação em SPECT e PET." reponame:Repositório Institucional do IPEN, 2014. http://repositorio.ipen.br:8080/xmlui/handle/123456789/25357.

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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2015-12-22T09:27:04Z No. of bitstreams: 0<br>Made available in DSpace on 2015-12-22T09:27:04Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado em Tecnologia Nuclear)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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18

Fischer, Gabriel [Verfasser], and Carmen [Akademischer Betreuer] Wängler. "Entwicklung neuer multimerer PET-Tracer zur verbesserten Diagnostik von Prostatakarzinomen : eine Studie von der Darstellung multivalenter Grundgerüste bis zum applikationsfertigen Radiotracer / Gabriel Fischer ; Betreuer: Carmen Wängler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1122435568/34.

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19

Gabor, Sabine [Verfasser], and Stefanie [Gutachter] Hahner. "Präklinische Evaluation von Aldosteronsynthaseinhibitoren als PET-Tracer für die Differentialdiagnostik des primären Hyperaldosteronismus mit besonderem Fokus auf Cyanofluorphenylpyridinen und deren Derivate / Sabine Gabor ; Gutachter: Stefanie Hahner." Würzburg : Universität Würzburg, 2016. http://d-nb.info/1137835893/34.

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20

Earla, Janaki Ram Prasad. "Assessment of the Effect of Cancer and its Treatment on PET Scan F-18 Tracer Distribution in Pre- and Post-treatment and its Relation to Myocardial Tissue Uptake." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1125072033.

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21

Labadi, Adnan Ghaleb Mohammed al. "Nucleophilic aromatic substitution by [18F]fluoride and its applications to the synthesis of model precursors for the multi-step synthesis of the PET-tracer 6-[18F]fluoro-L-DOPA." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980292638.

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22

Tonietto, Matteo. "A Unified Framework For Blood Data Modeling In Dynamic Positron Emission Tomography Studies." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3424684.

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Quantification of dynamic PET images requires the measurement of radioligand concentrations in the arterial plasma. In general, this cannot be derived from PET images directly but it must be measured from blood samples taken from the subject’s radial artery. The aim of this thesis was to develop and validate a unified framework for the blood data modeling, which was both biologically and experimentally informed, in order to achieve a better description of the blood data.<br>La quantificazione di immagini dinamiche PET (Tomografia ad Emissione di Positroni) richiede la misurazione della con

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23

Liu, Zhen [Verfasser], Sibylle [Akademischer Betreuer] Ziegler, Gabriele [Gutachter] Multhoff, and Gil G. [Gutachter] Westermeyer. "Real-time Investigation of Underlying Physiology behind PET Tracer Uptake based on Positron Imaging of a Microfluidic Chip and a Window Chamber / Zhen Liu ; Gutachter: Gabriele Multhoff, Gil G. Westermeyer ; Betreuer: Sibylle Ziegler." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1141295997/34.

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24

Hartrampf, Philipp Emanuel [Verfasser], Andreas [Gutachter] Buck, and Hubert [Gutachter] Kübler. "Evaluation der PET-Tracer [\(^1\)\(^8\)F]FDG, [\(^1\)\(^8\)F]Cholin und [\(^6\)\(^8\)Ga]PSMA I&T zur nicht-invasiven Charakterisierung von Prostatakarzinomzellen und des Ansprechens auf eine Docetaxeltherapie / Philipp Emanuel Hartrampf ; Gutachter: Andreas Buck, Hubert Kübler." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1180982274/34.

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25

Kennel, Sybille. "Synthèse de traceurs bimodaux utilisables en imagerie médicale TEP/IRM." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0190/document.

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Aujourd’hui les médecins disposent de nombreuses techniques d’imagerie médicale afin d’établir des diagnostics précis et précoces. Cependant, chacune de ces techniques possède ses propres avantages et inconvénients. C’est pourquoi, l’utilisation de méthodes bi- ou multi-modales paraît intéressante. Parmi celles-ci, la combinaison TEP/IRM permet d’apporter des informations complémentaires. Il est alors nécessaire d’injecter aux patients un traceur adapté à chacune de ces modalités. Ce travail de thèse a donc consisté à synthétiser des plateformes moléculaires « universelles » utilisables pour l

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26

Olshen, Adam B. "Modeling PET blood curves /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/9530.

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27

Charoenphun, Putthiporn. "Long lived PET tracers for tracking labelled cells." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/long-lived-pet-tracers-for-tracking-labelled-cells(f264e449-cbf6-482a-af29-4f2cdd62830b).html.

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Cell tracking is important because the information it provides is required to inform cell based treatment development. Additionally, it has a diagnostic purpose for detecting infection/inflammation diseases with labelled cells, a technique that has become part of routine clinical practice. Currently only gamma emitting radiotracers for single photon emission computed tomography (SPECT) are available to label cells for routine service. PET (positron emission tomography) exhibits better resolution than SPECT and its use in cell tracking would improve image quality, detectability and quantificati

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28

Cybulska, Klaudia Aleksandra. "Sulfonium salts for the synthesis of PET tracers." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041838/.

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Positron Emission Tomography (PET) is a non-invasive medical imaging technique, which allows for quantification of biochemical processes in vivo by employing positron emitting radiopharmaceuticals. Fluorine-18 is the most widely used radionuclide due to its favourable physical properties. Despite impressive technological advancements and large investments in PET instrumentation, its full medical potential has not been realised. The lack of broadly applicable, versatile and robust 18F-labelling strategies hampers development of PET tracers. This work describes development and optimisation of di

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Testa, Andrea. "Development of PET tracers to study hepatic transporters." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228011.

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30

ANDREOLLI, ELENA MARIA. "Synthesis and development of positron-emitting tracers, labeled with carbon-11 and radiometals (Ga-68, Zr-89, Y-90 and Lu-177), and their potential use in oncology." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50483.

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Study of altered metabolism as well as accurate initial diagnosis and determination of the extent of diseases continue to be a major challenge for contribution in understanding the modification that can select appropriate treatment options, monitoring the effects of therapeutic interventions, and detecting disease after recurrence. Critical for new tracers’ development is the selection of appropriate targets. Two different molecular targets have been taken into consideration: 1) COX-2 for inflammation and cancer targeting; the work foresaw the labelling of a COX-2 selective inhibitor (VA426)

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31

Marie, Guillaume. "Exploration of new methods involved for the synthesis of PET tracers." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/67939/.

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This work describes the development and the optimisation of microfluidic radiolabelling by using an Eckert & Ziegler device remotely controlled by a computer to perform the multistep synthesis of [18F]-fluoro-2-deoxy-D-glucose ([18F]-FDG). This device was then modified to control the fluidic transfers via flow of nitrogen and vacuum with the aid of a new one-way cassette system by using different concentrations of water for the Kryptofix solution. A new route was also explored to perform florbetaben ([18F]-BAY94- 9172), a potent Alzheimer’s disease PET tracer. Chapter 1 is an overview of posit

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32

Marasligil, Mehmet Faik. "PAWMOJI: Emotionally Expressive Avatar for the Quantified Pet Users." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-235229.

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The primary aim of this study is to investigate the impact of an avatar to dog’s daily pet care for the quantified pet users. Furthermore, it explores the design challenges of creating a dog-like avatar for Human-Pet-Computer Interaction. Pawmoji, an emotionally expressive avatar, was designed as a supporting element on the interface to help users interpret the data and increase motivation. Pawmoji changes emotional states according to pet’s daily activities. The data from the device is conveyed to the user via changes in the emotional state of the avatar. This concept was evaluated by pet act

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33

Altomonte, Stefano. "Cannabinoid receptor subtype-1 (CB1) ligands : synthesis and brain PET imaging with 11C and 18F radiotracers." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=214832.

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34

Mattarella, Vincenzo. "Design e Sviluppo di un Tracer Distribuito e Modulare per Microservizi." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14810/.

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I sistemi distribuiti sono diventati molto importanti oggi e sempre più utilizzati. I microservizi sono l'attuale stato dell'arte all'interno dei sistemi distribuiti grazie alle loro caratteristiche. Immaginando di avere più microservizi attivi su differenti calcolatori o sistemi virtualizzati, sarebbe utile per lo sviluppatore avere, in primo luogo, un output nell'esecuzione, chiamato anche traccia o trace in inglese, per ognuno di questi microservizi che contenga tutte le informazioni riguardo l'esecuzione di ognuno di essi. In secondo luogo, sarebbe utile avere un 'traduttore' di questi f

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35

Samuelsson, Linda. "Methods for the Synthesis of PET Tracers and NMR Studies of Ribonuclease A." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5932.

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Carroll, Laurence. "Synthesis of 18F and 64Cu PET Tracers for the Detection of Hypoxic Tumours." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526575.

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37

Calamai, Elisa. "(18F) barbiturates as structurally novel PET tracers with diagnostic potential in Alzheimer's disease." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=220450.

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Alzheimer's Disease (AD) is the most common cause of dementia in elderly people. Although the exact pathogenesis of AD remains unclear, accumulation of β- amyloid (Aβ) plaques seems to be among the causative events. In view of this, Aβ- PET imaging is considered to be a powerful non-invasive diagnostic tool that could also contribute to the development of therapies by monitoring responses. However, Aβ-PET ligands approved so far can only detect heavy plaque load and cannot replace post-mortem examination of brain tissue. The aim of this multidisciplinary study was to develop structurally novel

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38

Haywood, Thomas. "[C-11] carbon disulfide : a versatile radiolabelling reagent for the development of PET tracers." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/34318.

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This thesis is concerned with the development and implementation of 11C carbon disulfide as a method of radiolabelling molecules to form radiotracers for application in positron emission tomography (PET). The development of the synthetic route to [11C] carbon disulfide is described. The preferred synthesis method for the main body of this work was to pass [11C] methyl iodide over sulfur at high temperature. Other methods of [11C] carbon disulfide production were also explored including synthesis from [11C] methane and also direct synthesis in the cyclotron target. Following the improved and ro

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Wållberg, Helena. "Design and Evaluation of Radiolabeled Affibody Tracers for Imaging of HER2-expressing Tumors." Doctoral thesis, KTH, Molekylär Bioteknologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-40890.

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The growing understanding of tumor biology and the identification of tumor specificgenetic and molecular alterations, such as the overexpression of human epidermal growthfactor receptor 2 (HER2), opens up for personalization of patient management using targeted therapies. However, this puts stringent demands on the diagnostic tools usedto identify patients that are likely to respond to a particular treatment. Radionuclide molecular imaging is a promising non-invasive method to visualize and characterize the expression of such targets. This thesis, based on five papers, is focused on the develo

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Vice, President Research Office of the. "Pop Art by the Pen." Office of the Vice President Research, The University of British Columbia, 2007. http://hdl.handle.net/2429/2682.

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Frau, Simona. "Fluoro-deoxy-carbohydrates as prosthetic groups for PET imaging : studies towards novel PET tracers for the cannabinoid system and angiogenesis-related receptors." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=225655.

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A novel class of potential positron emission tomography (PET) radiotracers for imaging aminopeptidase N (also known as APN or CD13) and cannabinoid type 1 (CB1) receptors were designed and synthesised with an efficient chemical strategy. Both targets have remarkable diagnostic and therapeutic potential, in fact the CD13 receptors are over-expressed during tumour angiogenesis and the CB1 receptors are highly expressed in the brain playing important functions in several pathophysiological processes. The target compounds were obtained by means of oxime-bio-conjugation between fluoro-deoxy-carbohy

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Gozal, Elizabeth A. "Trace amines as novel modulators of spinal motor function." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42864.

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Trace amines (TAs), tryptamine, tyramine, octopamine, and beta-phenylethylamine, named for their low endogenous concentrations in mammals, are related to the classical monoamine transmitters, but have been understudied and thought of as false transmitters. They share structural, physiological, pharmacological, and metabolic similarities with the monoamines, including synthesis by the aromatic-L-amino acid decarboxylase (AADC) enzyme. In 2001, a new class of receptors preferentially activated by the TAs, termed trace amine-associated receptors (TAARs), was discovered establishing a mechanism

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Vus, Stefanie [Verfasser], Heike [Gutachter] Endepols, and Bernd [Gutachter] Neumaier. "Präklinische Evaluation von PET Tracern für die neurologische Bildgebung / Stefanie Vus ; Gutachter: Heike Endepols, Bernd Neumaier." Köln : Universitäts- und Stadtbibliothek Köln, 2019. http://d-nb.info/1183255543/34.

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Fantoni, Enrico Raffaele. "Development and evaluation of a library of novel 18F-labelled PET tracers targeting the P2X7 receptor." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/development-and-evaluation-of-a-library-of-novel-18flabelled-pet-tracers-targeting-the-p2x7-receptor(f9c8a99f-a7c7-4526-99b1-5d90c2f3e52b).html.

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Inflammation imaging is central to the diagnosis and monitoring of the progression of a vast range of diseases. As is suggested by the strong upregulation in the presence of biological insults, the P2X7 receptor plays a fundamental role in the inflammatory cascade. In this context, the development of a centrally acting Positron Emission Tomography (PET) tracer is a promising step towards harnessing the therapeutic and diagnostic potential offered by this target. In this work, inspired by the known antagonist A-804598, a set of four novel 18F-labelled PET ligands were designed, synthesised and

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45

Liu, Cong. "New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/13709.

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Positron emission particle tracking (PEPT) is a non-invasive technique for studying the flow of particulate systems within industrial equipment. The technique tracks a tracer particle labelled with a positron emitting radionuclide moving within the field-of-view of a positron emission tomography (PET) scanner. Two important components of the technique are a PET camera and PEPT tracers, which are particle tracers labelled with a positron emitting radionuclide. Currently, the majority of PEPT tracers are made with 68Ga or 18F. However, the relatively short half-life of these two radionuclides li

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Musolino, Manuele. "Development and use of [18F]FDR as a new powerful radiolabelling agent for Positron Emission Tomography (PET) imaging of hypoxia." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=232411.

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In recent years tumour hypoxia has been extensively investigated, mainly because it is a source of resistance to the common radio and chemo therapies. In fact, the low levels and heterogeneous distribution of oxygen in hypoxic microenvironment render ionizing radiation ineffective in treating cell proliferation. Furthermore, a low oxygen concentration promotes the activation of HIF-1 transcription factor, which favours the development of a more malignant and resistant cancer cell phenotype often associated with poor prognosis. Positron Emission Tomography (PET) imaging is a valuable diagnostic

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Blair, David Stanley Hamilton. "Carbon and contaminant trace metal biogeochemistry in surficial organic-rich terrestrial systems." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/16231.

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Peats and organic-rich soils are a key part of the global carbon (C) cycle due to their sequestration and storage of atmospheric C as organic matter. Atmospheric deposition as a result of human activities has led to increased inventories of lead (Pb) and mercury (Hg) in UK peats and organic-rich soils. Ombrotrophic peat bogs, which receive all their nutrients and pollutants from the atmosphere, provide a historic record of Pb and Hg deposition within their solid phase. Organic-rich forest soil systems can also act as sinks for anthropogenic Pb but vertical transport of Pb can distort these tem

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Da, Ros Bryan. "Automatizzazione dei controlli di qualità per i sensori dei moduli dell'Inner Tracker dell'esperimento ATLAS per HL-LHC." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17813/.

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Il lavoro della mia tesi consiste nell'automatizzazione dei controlli di qualità dei moduli che andranno installati nel nuovo rivelatore interno di ATLAS, l'Inner Tracker, per la Fase II di LHC, High Luminosity - LHC. Per questa fase è previsto un incremento sostanziale della luminosità integrata e del pile-up delle collisioni. Pertanto, alcuni dei rivelatori che LHC ospita subiranno importanti modifiche. Il ruolo dell' INFN, nell'ambito della costruzione di ITk, è di progettare uno dei suoi end-cap. La realizzazione dei moduli che vi saranno installati comprende fasi di costruzione e assem

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Kühn, Anna [Verfasser]. "Longitudinale in vivo Charakterisierung patientenabgeleiteter Kolonkarzinom-Modelle mittels PET und die Evaluierung von Seneszenz-spezifischen Tracern / Anna Kühn." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1237011086/34.

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Zischler, Johannes Herbert [Verfasser], Bernd [Gutachter] Neumaier, and Ines [Gutachter] Neundorf. "Entwicklung neuer Übergangsmetall-vermittelter Radiofluorierungsmethoden zur Herstellung von PET-Tracern / Johannes Herbert Zischler ; Gutachter: Bernd Neumaier, Ines Neundorf." Köln : Universitäts- und Stadtbibliothek Köln, 2017. http://d-nb.info/1136077855/34.

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