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Journal articles on the topic 'PET tracer'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Ozenil, Marius, Jonas Aronow, Marlon Millard, et al. "Update on PET Tracer Development for Muscarinic Acetylcholine Receptors." Pharmaceuticals 14, no. 6 (2021): 530. http://dx.doi.org/10.3390/ph14060530.

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The muscarinic cholinergic system regulates peripheral and central nervous system functions, and, thus, their potential as a therapeutic target for several neurodegenerative diseases is undoubted. A clinically applicable positron emission tomography (PET) tracer would facilitate the monitoring of disease progression, elucidate the role of muscarinic acetylcholine receptors (mAChR) in disease development and would aid to clarify the diverse natural functions of mAChR regulation throughout the nervous system, which still are largely unresolved. Still, no mAChR PET tracer has yet found broad clin

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Koeppe, Robert A., David M. Raffel, Scott E. Snyder, Edward P. Ficaro, Michael R. Kilbourn, and David E. Kuhl. "Dual-[11C]Tracer Single-Acquisition Positron Emission Tomography Studies." Journal of Cerebral Blood Flow & Metabolism 21, no. 12 (2001): 1480–92. http://dx.doi.org/10.1097/00004647-200112000-00013.

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The ability to study multiple physiologic processes of the brain simultaneously within the same subject would provide a new means to explore the interactions between neurotransmitter systems in vivo. Currently, examination of two distinct neuropharmacologic measures with positron emission tomography (PET) necessitates performing two separate scans spaced in time to allow for radionuclide decay. The authors present results from a dual-tracer PET study protocol using a single dynamic-scan acquisition where the injections of two tracers are offset by several minutes. Kinetic analysis is used to e

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Mu, Linjing, Stefanie D. Krämer, Hazem Ahmed, et al. "Neuroimaging with Radiopharmaceuticals Targeting the Glutamatergic System." CHIMIA International Journal for Chemistry 74, no. 12 (2020): 960–67. http://dx.doi.org/10.2533/chimia.2020.960.

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Radiopharmacy at ETH has worked on the development of novel PET tracers for neuro-, cardiac- and tumor imaging for many years. In this paper, our efforts on targeting the glutamatergic system of the metabotropic glutamate receptor subtype 5 (mGluR5) and the ionotropic N-methyl-<small>D</small>-aspartate (NMDA) receptor are summarized. We briefly described the principles of positron emission tomography (PET) tracer development for the central nervous system (CNS) and the radiolabeling methods used in our laboratory. To assess the radioligands, results of in vitro autoradiography, bi

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Pan, Bolin, Paul K. Marsden, and Andrew J. Reader. "Dual-Tracer PET Image Separation by Deep Learning: A Simulation Study." Applied Sciences 13, no. 7 (2023): 4089. http://dx.doi.org/10.3390/app13074089.

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Multiplexed positron emission tomography (PET) imaging provides perfectly registered simultaneous functional and molecular imaging of more than one biomarker. However, the separation of the multiplexed PET signals within a single PET scan is challenging due to the fact that all PET tracers emit positrons, which, after annihilating with a nearby electron, give rise to 511 keV photon pairs that are detected in coincidence. Compartment modelling can separate single-tracer PET signals from multiplexed signals based on the differences in bio-distribution kinetics and radioactive decay. However, the

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Zanderigo, Francesca, Ramin V. Parsey, and R. Todd Ogden. "Model-Free Quantification of Dynamic PET Data Using Nonparametric Deconvolution." Journal of Cerebral Blood Flow & Metabolism 35, no. 8 (2015): 1368–79. http://dx.doi.org/10.1038/jcbfm.2015.65.

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Dynamic positron emission tomography (PET) data are usually quantified using compartment models (CMs) or derived graphical approaches. Often, however, CMs either do not properly describe the tracer kinetics, or are not identifiable, leading to nonphysiologic estimates of the tracer binding. The PET data are modeled as the convolution of the metabolite-corrected input function and the tracer impulse response function (IRF) in the tissue. Using nonparametric deconvolution methods, it is possible to obtain model-free estimates of the IRF, from which functionals related to tracer volume of distrib

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Joshi, Aniket D., Robert A. Koeppe, Jeffrey A. Fessier, and Michael R. Kilbourn. "Signal Separation and Parameter Estimation in Noninvasive Dual-Tracer PET Scans using Reference-Region Approaches." Journal of Cerebral Blood Flow & Metabolism 29, no. 7 (2009): 1346–57. http://dx.doi.org/10.1038/jcbfm.2009.53.

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This is the first study to report results from a noninvasive dual-tracer positron emission tomography (PET) in humans not requiring arterial sampling, in which two radiotracers were injected closely in time within the same scan. These studies yield near simultaneous information on two different neuropharmacological systems, providing better characterization of a subject's neurologic condition. The noninvasive dual-tracer approach described in this study is based on the primary assumption that an appropriate bolus plus constant infusion protocol brings the reference tissue of the first radiotra

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Calabria, Ferdinando, Robert Pichler, Mario Leporace, et al. "68Ga/64Cu PSMA Bio-Distribution in Prostate Cancer Patients: Potential Pitfalls for Different Tracers." Current Radiopharmaceuticals 12, no. 3 (2019): 238–46. http://dx.doi.org/10.2174/1874471012666190515090755.

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Background:68Ga-PSMA is a widely useful PET/CT tracer for prostate cancer imaging. Being a transmembrane protein acting as a glutamate carboxypeptidase enzyme, PSMA is highly expressed in prostate cancer cells. PSMA can also be labeled with 64Cu, offering a longer half-life and different resolution imaging. Several studies documented bio-distribution and pitfalls of 68Ga-PSMA as well as of 64Cu- PSMA. No data are reported on differences between these two variants of PSMA. Our aim was to evaluate physiological distribution of these two tracers and to analyze false positive cases.Methods:We exam

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Jødal, Lars, Svend B. Jensen, Ole L. Nielsen, et al. "Kinetic Modelling of Infection Tracers [18F]FDG, [68Ga]Ga-Citrate, [11C]Methionine, and [11C]Donepezil in a Porcine Osteomyelitis Model." Contrast Media & Molecular Imaging 2017 (2017): 1–18. http://dx.doi.org/10.1155/2017/9256858.

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Introduction. Positron emission tomography (PET) is increasingly applied for infection imaging using [18F]FDG as tracer, but uptake is unspecific. The present study compares the kinetics of [18F]FDG and three other PET tracers with relevance for infection imaging. Methods. A juvenile porcine osteomyelitis model was used. Eleven pigs underwent PET/CT with 60-minute dynamic PET imaging of [18F]FDG, [68Ga]Ga-citrate, [11C]methionine, and/or [11C]donepezil, along with blood sampling. For infectious lesions, kinetic modelling with one- and two-tissue-compartment models was conducted for each tracer

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Weigel, Katharina. "PET Imaging and Glioblastoma." Neurosurgery 84, no. 5 (2019): E273. http://dx.doi.org/10.1093/neuros/nyz001.ni3.

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Abstract INTRODUCTION Patients who present with Glioblastoma have a median survival of around 15 mo, even when treated with the most aggressive methods available. Imaging of glial cell tumours is faced with multiple challenges, including the accurate delineation of abnormal tissue and the identification of low-grade gliomas. PET imaging depicts aspects of tissue activity in Vivo and thus, helps us improve our understanding of the tumor's size and behavior. While functional imaging is already an established modality in other fields of oncology, the appropriate tracer for the imaging of glial ca

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Chan, Sik-Kwan, Wan Hang Keith Chiu, Ho Fun Victor Lee, et al. "Combined 18F-FDG and 11C-acetate positron emission tomography/computed tomography in staging and treatment decision in patients with hepatocellular carcinoma: A cost-effectiveness analysis." Journal of Clinical Oncology 40, no. 16_suppl (2022): e16176-e16176. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e16176.

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e16176 Background: Dual-tracer positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose and 11C-acetate is increasingly used in the management of hepatocellular carcinoma (HCC). However, considering the high cost of dual-tracer PET/CT, there is a need to assess its value by considering both the efficacy and cost. Methods: In this retrospective cohort study, 223 dual-tracer PET/CT scans were performed in 206 patients between 2014 and 2020 for tumor staging for radiologically or histologically confirmed HCC. New lesion detection rate, changes in the Barcelona Clinic

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Bischof, Gérard N. "Tau-PET Bildgebung der Demenzerkrankungen." Angewandte Nuklearmedizin 45, no. 04 (2022): 266–72. http://dx.doi.org/10.1055/a-1712-6020.

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ZusammenfassungDie Ablagerung von Tau-Proteinen ist ein grundlegendes pathophysiologisches Merkmal vieler neurodegenerativer Demenzerkrankungen. Die Entwicklung sensitiver Tau-PET Tracer in den letzten Jahren hat die Lokalisation von Tau-Ablagerungen in unterschiedlichen klinischen neurodegenerativen Phänotypen in vivo ermöglicht. Bei der Alzheimer Demenz sind die räumlichen Muster der Tau-Pathologie in temporalen, parietalen und frontalen Regionen mit der Neurodegeneration und klinischen Symptomatik korreliert. Des Weiteren zeigen sich Zusammenhänge mit der Schwere der kognitiven Beeinträchti

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Capotosti, Francesca. "a-synuclein PET Imaging: From Clinical Utility in Multiple System Atrophy to the Possible Diagnosis of Parkinson’s Disease." Cells 14, no. 11 (2025): 834. https://doi.org/10.3390/cells14110834.

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The development of PET tracers for the detection of pathological alpha-synuclein (a-synuclein) has the potential to revolutionize the diagnosis, monitoring, and therapeutic interventions of synucleinopathies, including Parkinson’s disease. The journey toward identifying effective PET imaging agents, however, has faced significant challenges due to the complexity and heterogeneity of the a-synuclein structures. Achieving the goal is further compounded by the low density of the pathological target, necessitating that the tracer exhibits a high binding potential, as well as the co-existence of ot

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Högnäsbacka, Antonia, Alex Poot, Danielle Vugts, Guus van Dongen, and Albert Windhorst. "The Development of Positron Emission Tomography Tracers for In Vivo Targeting the Kinase Domain of the Epidermal Growth Factor Receptor." Pharmaceuticals 15, no. 4 (2022): 450. http://dx.doi.org/10.3390/ph15040450.

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Multiple small molecule PET tracers have been developed for the imaging of the epidermal growth factor receptor (EGFR). These tracers target the tyrosine kinase (TK) domain of the receptor and have been used for both quantifying EGFR expression and to differentiate between EGFR mutational statuses. However, the approaches for in vivo evaluation of these tracers are diverse and have resulted in data that are hard to compare. In this review, we analyze the historical development of the in vivo evaluation approaches, starting from the first EGFR TK PET tracer [11C]PD153035 to tracers developed ba

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Aboian, Mariam, Vahid Ravanfar, Emma Bahroos, et al. "MLTI-18. PRECISION IMAGING OF METASTATIC AND PRIMARY BRAIN TUMORS AFTER RADIATION WITH 18F-FDOPA PET-MRI IS FEASIBLE AND COST EFFECT." Neuro-Oncology Advances 1, Supplement_1 (2019): i18. http://dx.doi.org/10.1093/noajnl/vdz014.077.

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Abstract PURPOSE: Post-radiation changes in the brain can mimic tumor recurrence on MRI, requiring multiple short term follow-ups to differentiate tumor progression from radiation necrosis. We propose combining functional and anatomic imaging with FDOPA PET tracer in hybrid PET-MRI to improve detection of tumor recurrence. MATERIALS AND METHODS: Seventeen adult patients treated with radiation therapy were identified - four with metastatic disease from breast and lung cancer and thirteen with primary brain glioma (11 IDH wildtype glioblastoma and 2 astrocytoma). Patients were scanned on hybrid

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Maddahi, Jamshid. "Properties of an ideal PET perfusion tracer: New PET tracer cases and data." Journal of Nuclear Cardiology 19, S1 (2012): 30–37. http://dx.doi.org/10.1007/s12350-011-9491-8.

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Iacovitti, Cesare Michele, Marco Cuzzocrea, Lauro Gianola, Gaetano Paone, and Giorgio Treglia. "Dual-Tracer Positron Emission Tomography/Computed Tomography with [18F]FDG and [18F]fluorocholine in a Patient with Metastatic Parathyroid Carcinoma." Diagnostics 14, no. 14 (2024): 1548. http://dx.doi.org/10.3390/diagnostics14141548.

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Here, we describe the case of a 43-year-old male patient with a metastatic parathyroid carcinoma who underwent dual-tracer whole-body positron emission tomography/computed tomography (PET/CT) with [18F]fluorocholine and fluorodeoxyglucose ([18F]FDG) for staging. [18F]FDG PET/CT detected multiple cervical and mediastinal lymph nodal lesions with increased tracer uptake, whereas [18F]fluorocholine PET/CT detected increased tracer uptake on cervical and mediastinal lymph nodal lesions and bone and lung lesions with a better evaluation of metastatic spread. Due to these imaging findings, the patie

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Schwarzenböck, S., M. Schwaiger, and B. J. Krause. "Innovative Tracer in der onkologischen Diagnostik." Nuklearmedizin 49, S 01 (2010): S41—S45. http://dx.doi.org/10.1055/s-0038-1626531.

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SummaryIn oncology, PET and PET/CT with tracers beyond FDG target more specific biological processes, such as proliferation (18F-3'-fluoro-3'-deoxy-L-thymidine; 18F-FLT), tumour hypoxia (18F-fluoromisonidazol; 18F-FMISO) and phospholipid metabolism (radioactively labelled choline derivates).FLT is a thymidine analogue which can be labelled with 18F. PET with 18F-FLT enables to non-invasively image and to quantify the proliferation fraction of tumours. Proliferation dependent accumulation of FLT has been demonstrated for a variety of solid and haematologic neoplasms including lung cancer, breas

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Barthel, Henryk. "New PET tracer for angiogenesis." Lancet Oncology 5, no. 8 (2004): 462. http://dx.doi.org/10.1016/s1470-2045(04)01539-6.

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19

Bentourkia, M'hamed, and Habib Zaidi. "Tracer Kinetic Modeling in PET." PET Clinics 2, no. 2 (2007): 267–77. http://dx.doi.org/10.1016/j.cpet.2007.08.003.

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20

Sanduleanu, Sebastian, Alexander M. A. van der Wiel, Relinde I. Y. Lieverse, et al. "Hypoxia PET Imaging with [18F]-HX4—A Promising Next-Generation Tracer." Cancers 12, no. 5 (2020): 1322. http://dx.doi.org/10.3390/cancers12051322.

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Hypoxia—a common feature of the majority of solid tumors—is a negative prognostic factor, as it is associated with invasion, metastasis and therapy resistance. To date, a variety of methods are available for the assessment of tumor hypoxia, including the use of positron emission tomography (PET). A plethora of hypoxia PET tracers, each with its own strengths and limitations, has been developed and successfully validated, thereby providing useful prognostic or predictive information. The current review focusses on [18F]-HX4, a promising next-generation hypoxia PET tracer. After a brief history

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de Almeida, José, Sofia Martinho, Lino Gonçalves, and Maria Ferreira. "Positron Emission Tomography in Coronary Heart Disease." Applied Sciences 12, no. 9 (2022): 4704. http://dx.doi.org/10.3390/app12094704.

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With advances in scanner technology, postprocessing techniques, and the development of novel positron emission tomography (PET) tracers, the applications of PET for the study of coronary heart disease have been gaining momentum in the last few years. Depending on the tracer and acquisition protocol, cardiac PET can be used to evaluate the atherosclerotic lesion (plaque imaging) and to assess its potential consequences—ischemic versus nonischemic (perfusion imaging) and viable versus scarred (viability imaging) myocardium. The scope of this review is to summarize the role of PET in coronary hea

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Kumar, Ram, Nitin Gupta, Ritu Verma, and Ethel Belho. "Utility of different positron emission tomography/computed tomography tracers in the evaluation of incidentally detected dual malignancies: An experience from a tertiary care center." World Journal of Nuclear Medicine 20, no. 04 (2021): 382–85. http://dx.doi.org/10.4103/wjnm.wjnm_153_20.

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AbstractMultiple primary malignancies in a cancer patient are not a rare occurrence. The most common presentation of multiple primary malignancies is dual malignancies. The usefulness of different positron emission tomography (PET)/computed tomography (CT) tracers in the evaluation of dual synchronous primary malignancies is not well documented. Here, we present a case series, where two patients, referred for PET/CT, after being diagnosed with one primary malignancy were found to be having a second primary malignancy, diagnosed incidentally in PET/CT, further validated by PET/CT with another t

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Rapp, Marion, Frank W. Floeth, Jörg Felsberg, et al. "Clinical value of O-(2-[18F]-fluoroethyl)-L-tyrosine positron emission tomography in patients with low-grade glioma." Neurosurgical Focus 34, no. 2 (2013): E3. http://dx.doi.org/10.3171/2012.12.focus12336.

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Progress in morphological imaging has facilitated the diagnosis of low-grade glioma (LGG) and plays a decisive role in therapeutic decisions. To date, the method of choice is contrast-enhanced MRI including T1-/T2-weighted and FLAIR sequences. However, tumor delineation and the differentiation between neoplastic and normal brain tissue can be difficult when using morphological MRI and may complicate the identification of anaplastic foci for biopsy and further treatment planning. Furthermore, therapy monitoring and the differentiation of tumor recurrence from unspecific post-therapeutic changes

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Boutchko, Rostyslav, Debasis Mitra, Suzanne L. Baker, William J. Jagust, and Grant T. Gullberg. "Clustering-Initiated Factor Analysis Application for Tissue Classification in Dynamic Brain Positron Emission Tomography." Journal of Cerebral Blood Flow & Metabolism 35, no. 7 (2015): 1104–11. http://dx.doi.org/10.1038/jcbfm.2015.69.

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The goal is to quantify the fraction of tissues that exhibit specific tracer binding in dynamic brain positron emission tomography (PET). It is achieved using a new method of dynamic image processing: clustering-initiated factor analysis (CIFA). Standard processing of such data relies on region of interest analysis and approximate models of the tracer kinetics and of tissue properties, which can degrade accuracy and reproducibility of the analysis. Clustering-initiated factor analysis allows accurate determination of the time–activity curves and spatial distributions for tissues that exhibit s

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McDonald, Sam, Kevin G. Keane, Richard Gauci, and Dickon Hayne. "Nuclear Medicine and Molecular Imaging in Urothelial Cancer: Current Status and Future Directions." Cancers 17, no. 2 (2025): 232. https://doi.org/10.3390/cancers17020232.

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Background: The role of molecular imaging in urothelial cancer is less defined than other cancers, and its utility remains controversial due to limitations such as high urinary tracer excretion, complicating primary tumour assessment in the bladder and upper urinary tract. This review explores the current landscape of PET imaging in the clinical management of urothelial cancer, with a special emphasis on potential future advancements including emerging novel non-18F FDG PET agents, PET radiopharmaceuticals, and PET-MRI applications. Methods: We conducted a comprehensive literature search in th

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Qiu, Dongxu, Jian Li, Jinwei Zhang, et al. "Dual-tracer PET/CT-targeted, mpMRI-targeted, systematic biopsy, and combined biopsy for the diagnosis of prostate cancer." Journal of Clinical Oncology 40, no. 6_suppl (2022): 34. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.034.

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34 Background: Growing evidence proved the efficacy of multiparametric MRI (mpMRI) and prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT)-guided targeted biopsy (TB) in prostate cancer (PCa) diagnosis, but there is no direct comparison between mpMRI-TB and PSMA PET/CT-TB. Gastrin-releasing peptide receptor (GRPR) highly expressed in PCa, which can compensate for the unstable expression of PSMA in PCa. Therefore, we designed a study to compare the efficiency of mpMRI-TB, dual-Tracer (GRPR and PSMA) PET/CT-TB, systematic biopsy, and combined biops

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Palmisciano, Paolo, Gina Watanabe, Andie Conching, et al. "The Role of [68Ga]Ga-DOTA-SSTR PET Radiotracers in Brain Tumors: A Systematic Review of the Literature and Ongoing Clinical Trials." Cancers 14, no. 12 (2022): 2925. http://dx.doi.org/10.3390/cancers14122925.

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Background: The development of [68Ga]Ga-DOTA-SSTR PET tracers has garnered interest in neuro-oncology, to increase accuracy in diagnostic, radiation planning, and neurotheranostics protocols. We systematically reviewed the literature on the current uses of [68Ga]Ga-DOTA-SSTR PET in brain tumors. Methods: PubMed, Scopus, Web of Science, and Cochrane were searched in accordance with the PRISMA guidelines to include published studies and ongoing trials utilizing [68Ga]Ga-DOTA-SSTR PET in patients with brain tumors. Results: We included 63 published studies comprising 1030 patients with 1277 lesio

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Zhou, Xiaoyun, Bin Ji, Chie Seki, et al. "PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey." Journal of Cerebral Blood Flow & Metabolism 41, no. 9 (2021): 2410–22. http://dx.doi.org/10.1177/0271678x211004146.

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Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. In this study, we developed a novel PET radioligand for CSF1R, 11C-GW2580, and compared it to a reported CSF1R tracer, 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey. Dynamic 11C-GW2580- and 11C-CPPC-PET images were quantified by reference tissue-based models and standardized uptake value ratio. Both tracers exhibited increased uptake in the lesioned striata of lipopolysaccharide-injected mice and in the forebrains of AppNL-G-F/NL-G-F-knock-in mice, spatially in agreement w

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Natarajan, Arutselvan, Shyam M. Srinivas, Carmen Azevedo, et al. "Two Patient Studies of a Companion Diagnostic Immuno-Positron Emission Tomography (PET) Tracer for Measuring Human CA6 Expression in Cancer for Antibody Drug Conjugate (ADC) Therapy." Molecular Imaging 19 (January 1, 2020): 153601212093939. http://dx.doi.org/10.1177/1536012120939398.

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An antigen binding fragment (BFab) derived from a tumor-associated mucin 1–sialoglycotope antigen (CA6) targeting antibody (huDS6) was engineered. We synthesized a companion diagnostic positron emission tomography (PET) tracer by radiolabeling BFab with [64Cu] to measure CA6 expression on cancer tissues prior to anti-human CA6 (huDS6-DM4 antibody-drug conjugate) therapy for ovarian and breast cancer patients. After chemotherapy, the ovarian patient received PET scan with 18F-2-fluoro-2-deoxyglucose ([18F]FDG: 10 mCi), followed by [64Cu]-DOTA-BFab ([64Cu]BFab; 5.5 mCi) 1 week later for PET scan

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Kol, Arjan, Xiaoyu Fan, Marta A. Wazynska, et al. "Development of⁸⁹Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration." Journal for ImmunoTherapy of Cancer 10, no. 12 (2022): e004877. http://dx.doi.org/10.1136/jitc-2022-004877.

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PurposeCD103, an integrin specifically expressed on the surface of cancer-reactive T cells, is significantly increased during successful immunotherapy across human malignancies. In this study, we describe the generation and zirconium-89 (89Zr) radiolabeling of monoclonal antibody (mAb) clones that specifically recognize human CD103 for non-invasive immune positron-emission tomography (PET) imaging of T cell infiltration as potential biomarker for effective anticancer immune responses.Experimental designFirst, to determine the feasibility of anti-CD103 immuno-PET to visualize CD103-positive cel

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Zhang, Xiang, Falguni Basuli, Zhen-Dan Shi, et al. "Synthesis and Evaluation of Fluorine-18-Labeled L-Rhamnose Derivatives." Molecules 28, no. 9 (2023): 3773. http://dx.doi.org/10.3390/molecules28093773.

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The use of radiolabeled glucose for PET imaging resulted in the most commonly used tracer in the clinic, 2-deoxy-2-[18F]fluoroglucose (FDG). More recently, other radiolabeled sugars have been reported for various applications, including imaging tumors and infections. Therefore, in this study, we developed a series of fluorine-18-labeled L-rhamnose derivatives as potential PET tracers of various fungal and bacterial strains. Acetyl-protected triflate precursors of rhamnose were prepared and radiolabeled with fluorine-18 followed by hydrolysis to produce L-deoxy [18F]fluororhamnose. The overall

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Drescher, Robert, Falk Gühne, and Martin Freesmeyer. "Early-Dynamic Positron Emission Tomography (PET)/Computed Tomography and PET Angiography for Endoleak Detection After Endovascular Aneurysm Repair." Journal of Endovascular Therapy 24, no. 3 (2017): 421–24. http://dx.doi.org/10.1177/1526602817699397.

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Purpose: To propose a positron emission tomography (PET)/computed tomography (CT) protocol including early-dynamic and late-phase acquisitions to evaluate graft patency and aneurysm diameter, detect endoleaks, and rule out graft or vessel wall inflammation after endovascular aneurysm repair (EVAR) in one examination without intravenous contrast medium. Technique: Early-dynamic PET/CT of the endovascular prosthesis is performed for 180 seconds immediately after intravenous injection of F-18-fluorodeoxyglucose. Data are reconstructed in variable time frames (time periods after tracer injection)

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Metzner, Ralf, Antonia Chlubek, Jonas Bühler, et al. "In Vivo Imaging and Quantification of Carbon Tracer Dynamics in Nodulated Root Systems of Pea Plants." Plants 11, no. 5 (2022): 632. http://dx.doi.org/10.3390/plants11050632.

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Legumes associate with root colonizing rhizobia that provide fixed nitrogen to its plant host in exchange for recently fixed carbon. There is a lack of understanding of how individual plants modulate carbon allocation to a nodulated root system as a dynamic response to abiotic stimuli. One reason is that most approaches are based on destructive sampling, making quantification of localised carbon allocation dynamics in the root system difficult. We established an experimental workflow for routinely using non-invasive Positron Emission Tomography (PET) to follow the allocation of leaf-supplied 1

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Veenstra, Emile B., Simeon J. S. Ruiter, Robbert J. de Haas, et al. "A dual-tracer approach using [11C]CH and [18F]FDG in HCC clinical decision making." EJNMMI Research 13, no. 1 (2023). http://dx.doi.org/10.1186/s13550-023-01024-y.

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Abstract Background Early detection of recurrent or progressive HCC remains the strongest prognostic factor for survival. Dual tracer PET/CT imaging with [11C]CH and [18F]FDG can further increase detection rates as both tracers entail different metabolic pathways involved in HCC development. We investigated dual-tracer PET/CT in clinical decision making in patients suspected of recurrent or progressive HCC. All HCC patients who underwent both [11C]CH and [18F]FDG PET/CT in our institute from February 2018 to December 2021 were included. Both tracer PET/CT were within 4 weeks of each other with

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Pan, Bolin, Paul K. Marsden, and Andrew J. Reader. "Deep learned triple-tracer multiplexed PET myocardial image separation." Frontiers in Nuclear Medicine 4 (April 11, 2024). http://dx.doi.org/10.3389/fnume.2024.1379647.

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IntroductionIn multiplexed positron emission tomography (mPET) imaging, physiological and pathological information from different radiotracers can be observed simultaneously in a single dynamic PET scan. The separation of mPET signals within a single PET scan is challenging due to the fact that the PET scanner measures the sum of the PET signals of all the tracers. The conventional multi-tracer compartment modeling method (MTCM) requires staggered injections and assumes that the arterial input functions (AIFs) of each tracer are known.MethodsIn this work, we propose a deep learning-based metho

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Xu, Yiming, Yulong Xu, Savannah Biby, Changning Wang, and Shijun Zhang. "Development of NLRP3 PET Radiotracers for Alzheimer’s disease." Alzheimer's & Dementia 19, S17 (2023). http://dx.doi.org/10.1002/alz.071080.

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AbstractBackgroundNovel PET tracers were designed and tested to target the NLRP3 inflammasome in the brain to develop biomarkers for neuroinflammation in AD.MethodA novel chemical scaffold was rationally designed based on our previously developed NLRP3 inhibitors. One of the compounds, YM8, was radiolabeled with C‐11, and radiotracer was characterized in mouse models and non‐human primates (NHPs).ResultThe studies in wild type and nlrp3‐/‐ mouse brain tissues demonstrated that [11C]YM8 is a NLRP3 specific PET tracer with Bmax/Kd > 10, hinting to be a suitable CNS PET tracer. Studies in mice

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Steinz, Maarten M., Aiarpi Ezdoglian, Fatemeh Khodadust, et al. "Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis." Frontiers in Immunology 13 (February 2, 2022). http://dx.doi.org/10.3389/fimmu.2022.819163.

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Non-invasive imaging modalities constitute an increasingly important tool in diagnostic and therapy response monitoring of patients with autoimmune diseases, including rheumatoid arthritis (RA). In particular, macrophage imaging with positron emission tomography (PET) using novel radiotracers based on differential expression of plasma membrane proteins and functioning of cellular processes may be suited for this. Over the past decade, selective expression of folate receptor β (FRβ), a glycosylphosphatidylinositol-anchored plasma membrane protein, on myeloid cells has emerged as an attractive t

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Aboian, M. S., R. Barajas, J. Shatalov, et al. "Maximizing the use of batch production of 18F-FDOPA for imaging of brain tumors to increase availability of hybrid PET/MR imaging in clinical setting." Neuro-Oncology Practice, October 14, 2020. http://dx.doi.org/10.1093/nop/npaa065.

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Abstract Background Amino acid PET imaging of brain tumors has been shown to play an important role in predicting tumor grade, delineation of tumor margins, and differentiating tumor recurrence from the background of post-radiation changes, but is not commonly used in clinical practice due to high cost. We propose that PET/MRI imaging of patients grouped to the day of tracer radiosynthesis will significantly decrease the cost of PET imaging, which will improve patient access to PET. Methods Seventeen patients with either primary brain tumors or metastatic brain tumors were recruited for imagin

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Zhou, Yu‐Peng, Lauren L. Zhang, Yang Sun, and Pedro Brugarolas. "Imaging of pain using positron emission tomography." iRADIOLOGY, May 18, 2024. http://dx.doi.org/10.1002/ird3.73.

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AbstractPositron emission tomography (PET) is a noninvasive molecular imaging technique that utilizes biologically active radiolabeled compounds to image biochemical processes. As such, PET can provide important pathophysiological information associated with pain of different etiologies. Consequently, the information obtained using PET often combined with magnetic resonance imaging or computed tomography can provide useful information for diagnosing and monitoring changes associated with pain. This review covers the most important PET tracers that have been used to image pain including tracers

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Mohebbi, Alisa, Iman Kiani, Saeed Mohammadzadeh, Mohammad Mirza-Aghazadeh-Attari, Afshin Mohammadi, and Seyed Mohammad Tavangar. "Enhanced staging of extrahepatic hepatocellular carcinoma metastasis through dual-tracer PET/computed tomography: a systematic review and meta-analysis." Nuclear Medicine Communications, June 19, 2024. http://dx.doi.org/10.1097/mnm.0000000000001870.

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The aim of this study was to quantify the diagnostic value of dual-tracer PET/computed tomography (CT) with 11C-acetate and fluorodeoxyglucose (FDG) in per-lesion and per-patient and its effect on clinical decision-making for choosing the most appropriate management. The study protocol is registered a priori at https://osf.io/rvm75/. PubMed, Web of Science, Embase, and Cochrane Library were searched for relevant studies until 1 June 2023. Studies regarding the review question were included. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) was used to assess bias risk. Per-les

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Vraka, Chrysoula, Matej Murgaš, Lucas Rischka, et al. "Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-06906-0.

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AbstractSimultaneous characterization of pathologies by multi-tracer positron emission tomography (PET) is among the most promising applications in nuclear medicine. Aim of this work was the simultaneous production of two PET-tracers in one module and test the relevance for human application. [11C]harmine and [11C]DASB were concurrently synthesized in a ‘two-in-one-pot’ reaction in quality for application. Dual-tracer protocol was simulated using 16 single PET scans in different orders of tracer application separated by different time intervals. Volume of distribution was calculated for single

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Sun, Hao, Yanchao Huang, Debin Hu, et al. "Artificial intelligence-based joint attenuation and scatter correction strategies for multi-tracer total-body PET." EJNMMI Physics 11, no. 1 (2024). http://dx.doi.org/10.1186/s40658-024-00666-8.

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Abstract Background Low-dose ungated CT is commonly used for total-body PET attenuation and scatter correction (ASC). However, CT-based ASC (CT-ASC) is limited by radiation dose risks of CT examinations, propagation of CT-based artifacts and potential mismatches between PET and CT. We demonstrate the feasibility of direct ASC for multi-tracer total-body PET in the image domain. Methods Clinical uEXPLORER total-body PET/CT datasets of [18F]FDG (N = 52), [18F]FAPI (N = 46) and [68Ga]FAPI (N = 60) were retrospectively enrolled in this study. We developed an improved 3D conditional generative adve

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Wegen, Simone, Jasmin Weindler, Conrad-Amadeus Voltin, et al. "Dual-tracer PET/CT protocol with [18F]FDG and [68Ga]Ga-FAPI-46 outperforms single-tracer PET/CT with [18F]FDG in different cancer types, resulting in larger functional and gross tumor volume." Strahlentherapie und Onkologie, August 16, 2023. http://dx.doi.org/10.1007/s00066-023-02117-2.

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Abstract Purpose Fibroblast activation protein (FAP) detected by positron-emission tomography (PET) using fibroblast activation protein inhibitor (FAPI) appears to be a promising target for cancer imaging, staging, and therapy, providing added value and strength as a complement to [18F]fluorodeoxyglucose (FDG) in cancer imaging. We recently introduced a combined single-session/dual-tracer protocol with [18F]FDG and [68Ga]Ga-FAPI for cancer imaging and staging. Malignant tissue visualization and target-to-background uptake ratios (TBRs) as well as functional tumor volume (FTV) and gross tumor v

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Spoelstra, Gerbren B., Philip H. Elsinga, Jan Maarten van Dijl, et al. "Vancomycin-based tracers guiding in situ visualization of bacteria on osteosynthesis devices and surgical debridement." European Journal of Nuclear Medicine and Molecular Imaging, April 2, 2025. https://doi.org/10.1007/s00259-025-07249-4.

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Abstract Purpose Bacterial infections associated with musculoskeletal injuries are challenging to detect and distinguish from sterile inflammation. Here we present the combined first-time application of a bacteria-targeted positron emission tomography (PET) tracer and a near-infrared fluorescent tracer to detect infected osteosynthesis implants and guide surgical treatment. Methods To this end, osteosynthesis plates covered with bacterial biofilm and pre-incubated with [18F]PQ-VE1-vancomycin for PET imaging and/or vancomycin-IRDye800CW for optical imaging were fixed to post-mortem human tibiae

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Zeng, Fuzhen, Jingwan Fang, Amanjule Muhashi, and Huafeng Liu. "Direct reconstruction for simultaneous dual-tracer PET imaging based on multi-task learning." EJNMMI Research 13, no. 1 (2023). http://dx.doi.org/10.1186/s13550-023-00955-w.

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Abstract Background Simultaneous dual-tracer positron emission tomography (PET) imaging can observe two molecular targets in a single scan, which is conducive to disease diagnosis and tracking. Since the signals emitted by different tracers are the same, it is crucial to separate each single tracer from the mixed signals. The current study proposed a novel deep learning-based method to reconstruct single-tracer activity distributions from the dual-tracer sinogram. Methods We proposed the Multi-task CNN, a three-dimensional convolutional neural network (CNN) based on a framework of multi-task l

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Dev, Indraja D., Venkatesh Rangarajan, Nilendu C. Purandare, and Ameya D. Puranik. "Molecular Imaging of Glial Tumors: Established and Emerging Tracers." Indian Journal of Neurosurgery, July 24, 2023. http://dx.doi.org/10.1055/s-0043-1770910.

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AbstractVarious positron emission tomography (PET) tracers have been developed and extensively studied in the field of neuro-oncology imaging. In the management of brain tumors, accurate delineation of tumor extent, assessment of treatment response, and detection of early recurrence are the most important factors. At present, conventional anatomical imaging paired with amino acid tracer PET imaging is the recommended imaging modality for glial tumor evaluation. Newer PET tracers targeting various structures in the tumor microenvironment have been extensively studied. This review summarizes the

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Li, Fiona, Justin W. Hicks, Lihai Yu, et al. "Plasma radio-metabolite analysis of PET tracers for dynamic PET imaging: TLC and autoradiography." EJNMMI Research 10, no. 1 (2020). http://dx.doi.org/10.1186/s13550-020-00705-2.

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Abstract Background In molecular imaging with dynamic PET, the binding and dissociation of a targeted tracer is characterized by kinetics modeling which requires the arterial concentration of the tracer to be measured accurately. Once in the body the radiolabeled parent tracer may be subjected to hydrolysis, demethylation/dealkylation and other biochemical processes, resulting in the production and accumulation of different metabolites in blood which can be labeled with the same PET radionuclide as the parent. Since these radio-metabolites cannot be distinguished by PET scanning from the paren

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Finn, Quentin, Guilherme Povala, Guilherme Bauer‐Negrini, et al. "Exploring a weighted composite score for harmonization of 18F‐MK6240 and 18F‐ Flortaucipir: linearity and correlations with cognitive measures in a head‐to‐head tau PET dataset – The HEAD Study." Alzheimer's & Dementia 20, S2 (2024). https://doi.org/10.1002/alz.089551.

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AbstractBackgroundHarmonization of the two most commonly used Tau PET tracers, 18F‐Flortaucipir and 18F‐MK6240 has proven to be complex. Unlike the centiloid scale for amyloid tracers, Tau PET SUVRs of the two tracers are not linearly comparable and vary markedly in dynamic range and sensitivity.MethodTau PET SUVRs for Braak stage (1‐6) in 18F‐MK6240 and 18F‐Flortaucipir were obtained from the Longitudinal multicenter head‐to‐head harmonization of tau‐PET tracers (HEAD) project. For training, we used 13 amyloid confirmed AD, 24 amyloid confirmed MCI and 66 amyloid negative controls. To assess

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Chomet, Marion, Maxime Schreurs, Ricardo Vos, et al. "Performance of nanoScan PET/CT and PET/MR for quantitative imaging of 18F and 89Zr as compared with ex vivo biodistribution in tumor-bearing mice." EJNMMI Research 11, no. 1 (2021). http://dx.doi.org/10.1186/s13550-021-00799-2.

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Abstract Introduction The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imaging allows for noninvasive longitudinal evaluation of tracer distribution in the same animals, but systemic comparison with ex vivo biodistribution is lacking. Our aim was to evaluate the potential of preclinical PET imaging for accurate tracer quantification, especially in tumor models. Methods NEMA NU 4-2008 phantoms were filled with 11C, 68Ga, 18F, or 89Zr solutions

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Kendrick, Jake, Roslyn Francis, Ghulam Mubashar Hassan, et al. "Prospective inter- and intra-tracer repeatability analysis of radiomics features in [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]F-PSMA-1007 PET scans in metastatic prostate cancer." British Journal of Radiology, September 26, 2023. http://dx.doi.org/10.1259/bjr.20221178.

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Objective: This study aimed to quantify both the intra- and inter tracer repeatability of lesion-level radiomics features in [68Ga]Ga-PSMA-11 and [18F]F-PSMA-1007 PET scans. Methods: Eighteen patients with metastatic prostate cancer (mPCa) were prospectively recruited for the study and randomised to one of three test-retest groups: (i) intra tracer [68Ga]Ga-PSMA-11 PET, (ii) intra tracer [18F]F-PSMA-1007 PET or (iii) inter tracer between [68Ga]Ga-PSMA-11 and [18F]F-PSMA-1007 PET. Four conventional PET metrics (SUVmax, SUVmean, SUVtotal and volume) and 107 radiomics features were extracted from

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