Relevant bibliographies by topics / PHA 543613

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Academic literature on the topic 'PHA 543613'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "PHA 543613"

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Foucault-Fruchard, Laura, Aurélie Doméné, Guylene Page, et al. "Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model." Neuroscience 356 (May 18, 2017): 52–63. https://doi.org/10.1016/j.neuroscience.2017.05.019.

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Abstract Neuroinflammation is a key component of the pathophysiology of neurodegenerative diseases. The link between nicotine intake and positive outcome has been established, suggesting a role played by nicotinic receptors (nAChRs), especially α7nAChRs. The objective of this study was to evaluate the potential dose effects of PHA 543613 on neuron survival and striatal microglial activation in a rat model of brain excitotoxicity. A preliminary study was performed in vitro to confirm PHA 543613 agonist properties on α7nAChRs. Rats were lesioned in the right striatum with quinolinic
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Zhou, Yudi, Cheng Hu, Chenlu Mao, Sha Li, Yaomei Cui та Yanning Qian. "Electroacupuncture Ameliorates Tibial Fracture-Induced Cognitive Dysfunction by Elevating α7nAChR Expression and Suppressing Mast Cell Degranulation in the Hippocampus of Rats". Evidence-Based Complementary and Alternative Medicine 2022 (12 квітня 2022): 1–11. http://dx.doi.org/10.1155/2022/3182220.

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Intracerebral neuroinflammation, closely related to brain mast cell (MC) activation, performs an integral function in the pathogenic process of postoperative cognitive dysfunction (POCD). In addition to regulating cognitive activities, the alpha-7-nicotinic acetylcholine receptor (α7nAChR) engages in the progression of cognitive deficiency. In this research, we aimed to investigate how electroacupuncture (EA) affects the cognitive function in rats after tibial fracture surgery to determine whether the underlying mechanism involves the inhibition of hippocampal MC degranulation via α7nAChR. A r
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Foucault-Fruchard, Laura, Claire Tronel, Sylvie Bodard, et al. "Alpha-7 nicotinic acetylcholine receptor agonist treatment in a rat model of Huntington's disease and involvement of heme oxygenase-1." Neural Regen Res. 13, no. 4 (2018): 737–41. https://doi.org/10.4103/1673-5374.230301.

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<strong>Abstract</strong> Neuroinflammation is a common element involved in the pathophysiology of neurodegenerative diseases. We recently reported that repeated alpha-7 nicotinic acetylcholine receptor (&alpha;7nAChR) activations by a potent agonist such as PHA 543613 in quinolinic acid-injured rats exhibited protective effects on neurons. To further investigate the underlying mechanism, we established rat models of early-stage Huntington&#39;s disease by injection of quinolinic acid into the right striatum and then intraperitoneally injected 12 mg/kg PHA 543613 or sterile water, twice a day
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Sérrière, Sophie, Aurélie Doméné, Johnny Vercouillie та ін. "Assessment of the protection of dopaminergic neurons by an α7 nicotinic receptor agonist, PHA 543613 using [18F]LBT-999 in a Parkinson's disease rat model." Frontiers in Medicine 2 (17 серпня 2015): 61. https://doi.org/10.3389/fmed.2015.00061.

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The inverse association between nicotine intake and Parkinson&rsquo;s Disease (PD) is well established and suggests that this molecule could be neuroprotective through anti-inflammatory action mediated by nicotinic receptors, including the &alpha;7-subtype (&alpha;7R). The objective of this study was to evaluate the effects of an agonist of &alpha;7R, PHA 543613, on striatal dopaminergic neurodegeneration and neuroinflammation in a rat model of PD induced by 6-hydroxydopamine (6-OHDA) lesion. Adult male Wistar rats were lesioned in the right striatum and assigned to either the PHA group (n=7)
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Krafft, Paul R., Devin McBride, William B. Rolland, Tim Lekic, Jerry J. Flores та John H. Zhang. "α7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage". BioMed Research International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/8134653.

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Accounting for high mortality and morbidity rates, intracerebral hemorrhage (ICH) remains one of the most detrimental stroke subtypes lacking a specific therapy. Neuroinflammation contributes to ICH-induced brain injury and is associated with unfavorable outcomes. This study aimed to evaluate whetherα7 nicotinic acetylcholine receptor (α7nAChR) stimulation ameliorates neuroinflammation after ICH. Male CD-1 mice and Sprague-Dawley were subjected to intracerebral injection of autologous blood or bacterial collagenase. ICH animals received eitherα7nAChR agonist PHA-543613 alone or combined withα7
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Krafft, Paul R., Basak Caner, Damon Klebe, William B. Rolland, Jiping Tang, and John H. Zhang. "PHA-543613 Preserves Blood–Brain Barrier Integrity After Intracerebral Hemorrhage in Mice." Stroke 44, no. 6 (2013): 1743–47. http://dx.doi.org/10.1161/strokeaha.111.000427.

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Han, Qiao-Qiao, Meng-Yan Deng, Hao Liu, Usman Ali, Xin-Yan Li та Yong-Xiang Wang. "Cynandione A and PHA-543613 inhibit inflammation and stimulate macrophageal IL-10 expression following α7 nAChR activation". Biochemical Pharmacology 190 (серпень 2021): 114600. http://dx.doi.org/10.1016/j.bcp.2021.114600.

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Sadigh-Eteghad, S., M. Talebi, J. Mahmoudi, S. Babri та D. Shanehbandi. "Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25–35-mediated cognitive deficits in mice". Neuroscience 298 (липень 2015): 81–93. http://dx.doi.org/10.1016/j.neuroscience.2015.04.017.

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9

Foucault-Fruchard, Laura, Aurélie Doméné, Guylène Page, et al. "Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model." Neuroscience 356 (July 2017): 52–63. http://dx.doi.org/10.1016/j.neuroscience.2017.05.019.

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10

Macpherson, Alexandrea, Noha Zoheir, Raja Azman Awang, et al. "The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes." Inflammation Research 63, no. 7 (2014): 557–68. http://dx.doi.org/10.1007/s00011-014-0725-5.

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Conference papers on the topic "PHA 543613"

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Holman, Blair N., Robert J. Van Gulick, Carol Amato, Kasey Couts, and William A. Robinson. "Abstract 5431: Subungual melanoma: It may be a distinct entity." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5431.

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Elkashef, Sara M., Virginie Viprey, Rida F. Saeed, et al. "Abstract 5431: Polysialyltransferase ST8SiaII: A novel target for the treatment of neuroblastoma." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5431.

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Kumar, Suresh, James P. LaRocque, Jeffrey G. Marblestone, et al. "Abstract 5433: Discovery and development of novel USP2 inhibitors for cancer therapy." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5433.

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Lee, Yi-Te, Na Sun, Ryan Y. Zhang, et al. "Abstract 5436: Purification and mRNA profiling of extracellular vesicles for early detection of hepatocellular carcinoma." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5436.

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Middleton, Richard E., Greg Olsen, Russell McSweeney, et al. "Abstract 5436: Targeting oncoproteins via disruption of proteostasis: Identification of oncoprotein destabilizing agents using luciferase tagged oncoproteins." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5436.

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Reports on the topic "PHA 543613"

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จุฬาลักษณานุกูล, วรวุฒิ. การคัดแยกเชื้อและการวิเคราะห์บน 16 เอส ไรโบโซมัล ดีเอ็นเอของเชื้อคลอสทริเดียมที่สามารถผลิตอะซีโตน บิวทานอล และเอทานอล : รายงานวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2006. https://doi.org/10.58837/chula.res.2006.46.

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แบคทีเรียสกุลคลอสทริเดียม เป็นแบคทีเรียแอนแอโรบส์ (Anaerobes) แกรมบวก (Gram positive) ลักษณะเป็นรูปท่อน (Rod shape) สามารถสร้างสปอร์ได้ในสภาวะที่ไม่มีอากาศ ปัญหาสำคัญที่เกิดขึ้นคือการจัดจำแนกชนิดของแบคทีเรียในกลุ่มนี้ค่อนข้างยาก งานวิจัยนี้จึงใช้ลำดับเบสบน 16 เอส ไรโบโซมัล ดีเอ็นเอ เพื่อวิเคราะห์และเปรียบเทียบแบคทีเรียสกุลคลอสทริเดียมที่คัดแยกได้ กับฐานข้อมูลที่ได้มีการศึกษามาแล้ว โดยเริ่มจากการคัดแยกแบคทีเรีย ทดสอบความสามารถในการย่อยเซลลูโลส ทดสอบความสามารถในการเปลี่ยนซัลไฟต์เป็นซัลไฟด์ การสร้างเอ็นโดสปอร์ จากนั้นทำการสกัดดีเอ็นเอด้วยวิธีต้มเดือด เพิ่มปริมาณ 16 เอส ไรโบโซมัล ดีเอ็นเอ ด้วยวิธี
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