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Relevant bibliographies by topics / Phenothiazine drugs

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Academic literature on the topic 'Phenothiazine drugs'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Phenothiazine drugs"

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Steinbrecher, Kurt, C. A. Brunner, J. M. Newton, et al. "Thin Layer Chromatographic Identification of Phenothiazine Derivative Drugs: Interlaboratory Study." Journal of AOAC INTERNATIONAL 69, no. 6 (1986): 1030–34. http://dx.doi.org/10.1093/jaoac/69.6.1030.

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Abstract A thin layer chromatographic method for the identification of phenothiazine derivative drugs was studied collaboratively by 8 laboratories. Twenty phenothiazine drugs were examined by each collaborator. The identification scheme depends on the color of the sprayed spots and the Rf values relative to the Rf of chlorpromazine (RCHL) in 4 solvent systems. In 98.13% of the cases, a correct identification could be made; the remaining drugs were reduced to a choice between pairs of phenothiazines. With respect to chlorpromazine, the data showed a significant decrease in variability of RCHL

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Youssef, Adel F., Salwa R. El-Shabouri, Fardous A. Mohamed, and Abdel Maboud I. Rageh. "Colorimetric Determination of Certain Phenothiazine Drugs by Using Morpholine and Iodine-Potassium Iodide Reagents." Journal of AOAC INTERNATIONAL 69, no. 3 (1986): 513–18. http://dx.doi.org/10.1093/jaoac/69.3.513.

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Abstract A colorimetric method was developed for the quantitative estimation of 11 phenothiazine drugs. The method is based on the interaction of unsulfoxidized drug with morpholine and iodine-potassium iodide reagents. The interaction for all studied phenothiazine drugs yields a blue product with 2 absorption maxima: one in the range of 620-640 nm with lower molar absorptivity and the other in the range of 662-690 nm with higher molar absorptivity. The color was stable for at least 10 h. The reproducibility and recovery of the method were excellent. The method was applied successfully to the

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Khadieva, Alena, Olga Mostovaya, Pavel Padnya, et al. "Arylamine Analogs of Methylene Blue: Substituent Effect on Aggregation Behavior and DNA Binding." International Journal of Molecular Sciences 22, no. 11 (2021): 5847. http://dx.doi.org/10.3390/ijms22115847.

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The synthesis of new phenothiazine derivatives, analogs of Methylene Blue, is of particular interest in the design of new drugs, as well as in the development of a new generation of agents for photodynamic therapy. In this study, two new derivatives of phenothiazine, i.e., 3,7-bis(4-aminophenylamino)phenothiazin-5-ium chloride dihydrochloride (PTZ1) and 3,7-bis(4-sulfophenylamino)phenothiazin-5-ium chloride (PTZ2), are synthesized for the first time and characterized by NMR, IR spectroscopy, HRMS and elemental analysis. The interaction of the obtained compounds PTZ1 and PTZ2 with salmon sperm

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Dara, Abhilasha, I. Supriya, Sk Aneesa, K. Chennakesava, and P. Sindhu. "Design, Synthesis and Biological Evaluation of Novel Phenothiazines for Cancer Exploring through Anti-Oxidant and Anti-Inflammatory Activities." Scholars Academic Journal of Pharmacy 13, no. 10 (2024): 419–18. https://doi.org/10.36347/sajp.2024.v13i10.002.

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Cancer is defined as development of number of abnormal cells by uncontrollable cell division leads to the tissue detriment. It has the ability to spread throughout the body. Cancer is second-leading disease to cause the death in the world. Now-a-days survival rate for cancer may increase through the treatment. In this study, the cancer is treated by exploring the anti-oxidant and anti-inflammatory activity of novel Phenothiazines. Because anti-oxidants play a vital role in treatment of cancer by reducing the oxidative stress, abnormal cell division reduction, decrease in DNA damage, and reduce

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JAYARAMA, N. THIMMAIAH K., and VIOLET D'SOUZA M. "Novel Coordination Compounds of Mercury(ll) with Phenothiazine Drugs." Journal of Indian Chemical Society Vol. 62, Jun 1985 (1985): 418–20. https://doi.org/10.5281/zenodo.6318823.

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Department of Post-Graduate Studies and Research in Chemistry, University of Mysore, Mysore-570 006 <em>Manuscript received 30 September 1982, revised 7 May 1984, accepted 29 April 1988</em> The method of synthesis and properties of some novel complexes of Hg<sup>II</sup> with phenothiazine drugs are described. Complexes are of the type HgCI<sub>2</sub>.LH, where<em> </em>LH.= protonated phenothiazine drugs.  

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Qi, Lu, and YanQing Ding. "Potential antitumor mechanisms of phenothiazine drugs." Science China Life Sciences 56, no. 11 (2013): 1020–27. http://dx.doi.org/10.1007/s11427-013-4561-6.

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REVANASIDDAPPA, H., and P. RAMAPPA. "Spectrophotometric determinations of some phenothiazine drugs." Talanta 43, no. 8 (1996): 1291–96. http://dx.doi.org/10.1016/0039-9140(96)01861-9.

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KAHN, ANDRÉ. "Phenothiazine-Induced Sleep Apneas and the Opioid System." Pediatrics 77, no. 2 (1986): 262. http://dx.doi.org/10.1542/peds.77.2.262.

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In Reply.— Dr Sandyk suggests that the increased number of apneas seen in sleeping infants after the administration of phenothiazine could be related to an increase in endogenous opioids. If validated, this suggestion could be of interest for the understanding of the mechanisms inducing central and obstructive sleep apneas. As suggested naloxone could be tried in case of phenothiazine-induced apneas, but it seems advisable to systematically avoid the administration of phenothiazine-containing drugs to children younger than 2 years of age.

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Talwar, Reshu, and Rakesh Kumar Mahajan. "Electrochemical Measurements of Phenothiazine Drugs in the Presence of Surface Active Ionic Liquids." Key Engineering Materials 605 (April 2014): 581–84. http://dx.doi.org/10.4028/www.scientific.net/kem.605.581.

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The present study aims to explore the interactions between phenothiazine drugs (viz. promethazine hydrochloride (PMT) and promazine hydrochloride (PMZ)) and 1-alkyl-3-butylimidazolium based surface active ionic liquids (SAILs) using conductivity, cyclic voltammetry and DPV measurements. The drugs have been found to form mixed micelles with the SAILs and thus vary the micellar parameters of SAILs as evaluated from conductivity measurements,. Moreover, phenothiazine drugs are known to exhibit redox behavior which is prone to change in the presence of SAILs. This change in the redox active behavi

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Takorabet, L., A. Ropars, C. Raby, and J. Charreire. "Phenothiazine induces de novo MHC class II antigen expression on thyroid epithelial cells. A new mechanism for drug-induced autoimmunity." Journal of Immunology 154, no. 7 (1995): 3593–602. http://dx.doi.org/10.4049/jimmunol.154.7.3593.

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Abstract Autoimmune responses are initiated by MHC class II-restricted T cell responses directed against tissue-specific autoantigens. Furthermore, HLA-DR expression in thyroid epithelial cells is a prominent feature of autoimmune thyroid disease. In the present work, we were particularly interested in a phenothiazine, a neuroleptic and anti-depressant drug of pharmacologic importance named alimemazine. Our interest in this compound stems from previous findings of immune effects of this and other phenothiazines. We demonstrate that MHC class II Ags can be experimentally induced on thyroid cell

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Dissertations / Theses on the topic "Phenothiazine drugs"

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Jones, T. "Structure disposition relationships amongst phenothiazine drugs." Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379191.

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Blankert, Bertrand. "Développement de méthodes électroanalytiques hybrides pour l'étude de la biotransformation des médicaments." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210863.

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Le thème principal de notre travail consistait en la mise en exergue de l'efficience de la mise en œuvre de techniques hybrides associant l’électrochimie à l’élément biologique (biocapteur) ou l’électrochimie aux performances de la spectrométrie de masse (couplage EC-MS). Les informations fournies, jointes aux résultats des mesures en voltampérométrie sur électrodes solides, permettent une bonne compréhension mécanistique quant au devenir oxydatif de substances médicamenteuses. <p>Notre champ d'investigation s'est plus spécifiquement focalisé sur deux familles de molécules psychotropes (les ph

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Dunbar, Philip Gordon. "Approaches to the synthesis of pentacyclic dibenzazepines and phenothiazines." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184295.

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Rigid analogues of the tricyclic antidepressant imipramine and the phenothiazine tranquilizer promazine were designed and their syntheses were attempted. Conformational rigidity was expected to reduce the side effects of these drugs by limiting their binding to multiple receptors. Ortho-directed metalation followed by acylation provided synthetic intermediates for the formation of the desired pentacyclic congeners. The known dilithiation of phenothiazine and iminodibenzyl and n-butyllithium, followed by acylation with dimethylformamide, gave carboxaldehydes at the 1 and 4 positions respectivel

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Omoruyi, Sylvester Ifeanyi. "Investigating the anti-cancer activity of novel phenothiazines in glioblastoma." University of the Western Cape, 2018. http://hdl.handle.net/11394/6329.

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Philosophiae Doctor - PhD<br>Glioblastoma multiforme (GBM) remains the most malignant of all primary adult brain tumours. It is a highly invasive and vascularized neoplasm with limited treatment options and very low survival rate. GBM tumours are heterogeneous in nature with cellular hierarchy and at the apex of this hierarchy are the glioblastoma stem cells, known to promote tumourigenesis and resistance to chemotherapeutic agents and tumour recurrence. Currently, the standard care for GBM involves surgical resection, radiation, and chemotherapy treatment with temozolomide. Unfortunately, med

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Semenya, Manare Molahlegi Dorothy. "Non-Neuroleptic Antitubercular and Anticancer Therapeutics through Rational Drug Remodelling of Phenothiazines and Related Antipsychotics." Thesis, Faculty of Science, 2021. http://hdl.handle.net/11427/33391.

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In light of shrinking pharmaceutical drug pipelines and drug resistance, innovative drug discovery strategies are of imperative need. Drug repurposing and related strategies such as drug rescue and drug remodelling have garnered significant research interest. Various clinically approved non-antibiotics including phenothiazines hold promise as novel classes of therapeutics in other indications. However, in addition to inherent neuroleptic properties, phenothiazines and related antipsychotics elicit adverse side effects at clinically relevant doses thus precluding their extensive clinical applic

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Stutzmann, Aurélien. "Synthèse de dérivés de la phénothiazine et étude de leur rôle d'inhibiteurs de la résistance aux antibiotiques chez les Burkholderiaceae." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0628.

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Si les antibiotiques ont amélioré le pronostic des maladies infectieuses, l’apparition de résistances importantes et les manipulations génétiques volontaires peuvent faire craindre l’émergence de pathogènes très virulents et résistants aux antibiotiques recommandés. Aussi, la multidrug résistance (MDR) est devenue un problème majeur pour traiter des infections impliquant des bactéries à Gram-négatif. La surexpression des mécanismes d’efflux contribue largement au phénotype de multi-résistance aux antibiotiques et l’inhibition de ces mécanismes intéresse donc de plus en plus le monde de la rech

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Stutzmann, Aurélien. "Synthèse de dérivés de la phénothiazine et étude de leur rôle d'inhibiteurs de la résistance aux antibiotiques chez les Burkholderiaceae." Electronic Thesis or Diss., Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0628.

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Si les antibiotiques ont amélioré le pronostic des maladies infectieuses, l’apparition de résistances importantes et les manipulations génétiques volontaires peuvent faire craindre l’émergence de pathogènes très virulents et résistants aux antibiotiques recommandés. Aussi, la multidrug résistance (MDR) est devenue un problème majeur pour traiter des infections impliquant des bactéries à Gram-négatif. La surexpression des mécanismes d’efflux contribue largement au phénotype de multi-résistance aux antibiotiques et l’inhibition de ces mécanismes intéresse donc de plus en plus le monde de la rech

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Swamy, Krishna M. V. "Studies on charge-transfer complexes with special reference to phenothiazine drugs." Thesis, 1988. http://hdl.handle.net/2009/1891.

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Wang, Hsin-Jung, and 汪欣蓉. "Simultaneous determination of phenothiazine drugs in human urine sample using dispersive liquid-liquid microextraction combined with capillary electrophoresis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/80296469338876862297.

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碩士<br>國立高雄師範大學<br>化學系<br>103<br>Dispersive liquid-liquid microextraction followed by viscosity and field-amplifed sample stacking in capillary electrophoresis was determined to be a simple, fast and sensitive analytical method for simultaneously detecting three phenothiazines (promazine, chlorpromazine, and triflupromazine) in a human urine sample. The separation buffer was composed of 40mM phosphate solution (pH 2.5) and 10% (v/v) glycerol. Because glycerol exhibits viscosity, the resolution of the samples and the effect of the stacking could be substantially improved. Under optimized conditi

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Lee, Meng-Hua, and 李孟樺. "Identification of the phenothiazine-derived drug targeting the KRAS-mutant cells in non-small cell lung cancer." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/84579246041355665578.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>103<br>Thioridazine is a class of anti-psychotic drug called phenothiazine for the treatment of schizophrenia. Recently, we and others have shown that thioridazine is a cancer stem cell (CSC) inhibitor. However, the molecular mechanism of thioridazine in anti-CSC effect has not been elucidated. Interestingly, thioridazine has R and S two enantiomes. In this study, we hypothesized that these two enantiomers (referred to as T1 and T2) of thioridazine might inhibit the lung cancer cells with distinct efficacy and through different mechanisms. Here, we employed the L1000

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Books on the topic "Phenothiazine drugs"

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Ghuwar, Ramadan. Aspects of the analytical chemistry of phenothiazine drugs. University of Salford, 1995.

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Book chapters on the topic "Phenothiazine drugs"

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Attwood, D., E. Boitard, J. P. Dubès, H. Tachoire, V. Mosquera, and V. Perez Villar. "Association Models for Phenothiazine Drugs in Aqueous Solution." In The Structure, Dynamics and Equilibrium Properties of Colloidal Systems. Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3746-1_8.

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McKay, G., S. F. Cooper, and K. K. Midha. "Determination of Phenothiazines: The Present-Day Scene." In BIOACTIVE ANALYTES, Including CNS Drugs, Peptides, and Enantiomers. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4757-1892-8_14.

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Wyatt, Jonathan P., Robert G. Taylor, Kerstin de Wit, Emily J. Hotton, Robin J. Illingworth, and Colin E. Robertson. "Toxicology." In Oxford Handbook of Emergency Medicine. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198784197.003.0004.

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This chapter in the Oxford Handbook of Emergency Medicine encompasses toxicology in the emergency department (ED). It examines poisons in general, including diagnosis, supportive care, reducing absorption, and antidotes. Specific poisoning is explored in detail, through opioid, salicylate, paracetamol, tricyclic antidepressant, benzodiazepine, clomethiazole, phenothiazine, barbiturate, lithium, sulfonylurea, beta-blocker, calcium channel antagonist, digoxin, angiotensin-converting enzyme (ACE) inhibitor, theophylline, salbutamol, iron, ethanol, methanol, ethylene glycol, paraquat, petrol, para

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Pagliaro, Louis A., and Ann Marie Pagliaro. "Phenothiazines." In Psychologists’ Psychotropic Drug Reference. Routledge, 2020. http://dx.doi.org/10.4324/9781315825731-89.

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Rashid, Mamoon, Mehbuba Rahman, and M. O. Faruk Khan. "Phenothiazines and Related Antipsychotic Drugs." In Medicinal Chemistry of Drugs Affecting the Nervous System. BENTHAM SCIENCE PUBLISHERS, 2020. http://dx.doi.org/10.2174/9789811454073120020005.

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Ferner, R. E., Elizabeth Norman, and M. D. Rawlins. "The antipsychotic drugs: phenothiazines, butyrophenones, and other agents." In Forensic Pharmacology. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780198548263.003.0012.

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Abstract Psychological illnesses can be divided into neurotic and psychotic illnesses. Neurotic illnesses, such as anxiety and depression, are exaggerations of the normal emotions, but (generally) leave the thought processes intact. Psychotic illnesses are marked by a break from normal thought processes. The abnormal thoughts can take the form of hallucinations or delusions, for example. A patient who is miserable because he has no power to influence the wrongs of the world is neurotic; a patient who believes that the Martians are trying to destroy him, or that he himself is a Martian, is psyc

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Leonard, Brian E. "THE PHARMACOLOGY OF THE PHENOTHIAZINES, BUTYROPHENONES, THIOXANTHINES AND DIPHENYLBUTYLPIPERIDINES." In Antipsychotic Drugs and their Side-Effects. Elsevier, 1993. http://dx.doi.org/10.1016/b978-0-12-079035-7.50008-7.

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"Antidepressants Used as Chemotherapy for Trypanosoma cruzi Infection: Phenothiazines and Derivative Compounds." In Frontiers in Anti-Infective Drug Discovery, edited by Patricia Paglini Oliva, Silvina Lo Presti, and Walter Rivarola. BENTHAM SCIENCE PUBLISHERS, 2015. http://dx.doi.org/10.2174/9781681080826115040004.

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Davis, Julian R. E. "Hyperprolactinaemic anovulation." In Oxford Textbook of Endocrinology and Diabetes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235292.003.0846.

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Prolactin is a polypeptide hormone, named from its well-known effects to promote lactation. It is essential for successful reproduction in man and mammals, although it is known to have a wide variety of nonreproductive effects whose clinical significance remains uncertain. Hyperprolactinaemia, reflecting sustained overproduction of lactin by the pituitary, is relatively common in the population. The commonest cause is the use of drugs that have dopamine D2 receptor antagonist activity (e.g. antipsychotic agents such as phenothiazines), pregnancy and lactation are the commonest physiological ca

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Conference papers on the topic "Phenothiazine drugs"

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Rodrigues da Silva, Abdênego, Fernanda Viana Cabral, Adriana Fontes, and Martha Ribeiro Simões. "Light-based antifungal strategy for the control of Candida auris." In Latin America Optics and Photonics Conference. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/laop.2022.w4a.58.

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Candida auris is a pathogen that has been attracting worldwide focus due to its high resistance to conventional drugs. This work evaluated the photodynamic inactivation mediated by two phenothiazine dyes against the CBS 10913 strain.

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Posso, Marina Cassago, João Lourenço Serrano, Paulo Almeida, Fernanda Domingues, Samuel Silvestre, and Susana Ferreira. "New Fluoroquinolone–Phenothiazine Hybrids and Their Antimicrobial Activity." In The 2nd International Electronic Conference on Antibiotics—Drugs for Superbugs: Antibiotic Discovery, Modes of Action And Mechanisms of Resistance. MDPI, 2022. http://dx.doi.org/10.3390/eca2022-12722.

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Vesenbeckh, Silvan, David Krieger, Gudrun Bettermann, et al. "Neuroleptic drugs as potential adjuvants in the treatment of MDR-TB: Minimal inhibitory concentrations (MICs) of different phenothiazines againstM. tuberculosis." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa3329.

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