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Journal articles on the topic 'Phenylpiperazine substitutee'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Verdonk, M. L., J. W. Voogd, J. A. Kanters, et al. "Structure and Serotonin 5-HT2C Receptor Activity of ortho- and meta-Substituted Phenylpiperazines." Acta Crystallographica Section B Structural Science 53, no. 6 (1997): 976–83. http://dx.doi.org/10.1107/s0108768197009142.

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The structural characteristics of ortho- and meta-substituted phenylpiperazines have been investigated in order to understand their actions at the serotonin 5-HT2c receptor. The crystal structures of the 4-methylated analogues of two phenylpiperazines that are already known as 5-HT2c ligands, 1-(1-naphthyl)-4-methylpiperazine (1NMP) and 1-[(3-trifluoromethyl)phenyl]-4-methylpiperazine (TFMPMP), and those of two novel 5-HT2c ligands, 1-(2-methoxyphenyl)piperazine (oMPP) and 1-(3-methoxyphenyl)piperazine (mMPP), are determined. Molecular mechanics calculations are performed to calculate the ener

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2

Wang, Cheng Jun, Shan Shan Gong, and Qi Sun. "Synthesis of an Akt Inhibitor-IV Analogue via an Amine-Exchange Reaction." Advanced Materials Research 1023 (August 2014): 47–50. http://dx.doi.org/10.4028/www.scientific.net/amr.1023.47.

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3

Padrtová, Tereza, Pavlína Marvanová, Renáta Kubínová, et al. "Indol-2-Carboxylic Acid Esters Containing N-Phenylpiperazine Moiety - Preparation and Cholinesterase-inhibiting Activity." Current Organic Synthesis 17, no. 7 (2020): 576–87. http://dx.doi.org/10.2174/1570179417666200619132218.

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Background: The indole derivatives and the N-phenylpiperazine fragment represent interesting molecular moieties suitable for the research of new potentially biologically active compounds. This study was undertaken to identify if indol-2-carboxylic acid esters containing N-phenylpiperazine moiety possess acetylcholinesterase and butyrylcholinesterase inhibitory activity. Materials and Methods: The study dealt with the synthesis of a novel series of analogs of 1H-indole-2- carboxylic acid and 3-methyl-1H-indole-2-carboxylic acid. The structure of the derivatives was represented by the indolylcar

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4

Špirková, Katarína, Rudolf Kada, Jaroslav Kováč, Viera Knoppová, Miroslav Dzuroška, and Margita Margušová. "A study of reactions of 5-substituted furfurylidene derivatives with secondary amines." Collection of Czechoslovak Chemical Communications 50, no. 2 (1985): 459–69. http://dx.doi.org/10.1135/cccc19850459.

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The paper describes preparation of 5-bromo-, 5-nitro-, 5-phenylsulphonyl-, and 5-phenylthio-2-furfurylidene derivatives and investigation of their reactions with N-phenylpiperazine, morpholine, piperidine, and pyrrolidine. Kinetics of the reactions have been followed, and UV, IR, and 1H NMR spectra of the compounds produced are interpreted.

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5

Nematollahi, Davood, and Amene Amani. "Electrochemical synthesis of the new substituted phenylpiperazines." Journal of Electroanalytical Chemistry 651, no. 1 (2011): 72–79. http://dx.doi.org/10.1016/j.jelechem.2010.10.024.

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6

Štetinová, Jarmila, Adolf Jurášek, Jaroslav Kováč, Miloslava Dandárová, and Oľga Rajniaková. "Synthesis and properties of 4-alkylaminomethyl and 4-alkoxymethyl derivatives of 5-methyl-2-furancarboxylic acid." Collection of Czechoslovak Chemical Communications 51, no. 10 (1986): 2186–92. http://dx.doi.org/10.1135/cccc19862186.

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New β-substituted amines and ethers of the furan series (II-V) were prepared by reaction of methyl 4-bromomethyl-5-methyl-2-furancarboxylate (I) with nucleophiles such as pyrrolidine, piperidine, morpholine, N-phenylpiperazine, cyclohexylamine, 2-methylcyclohexylamine, N-ethylaniline, p-toluidine, ethanol, butanol and salicylaldehyde. The structure of the products was confirmed by their analytical and spectral data. Kovats indices I for the products were determined using gas-liquid chromatography.

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7

Acosta Quintero, Lina M., Alirio Palma, Justo Cobo, and Christopher Glidewell. "A versatile synthesis of cyclic dipeptides using the stepwise construction of the piperazine-2,5-dione ring from simple precursors: synthetic sequence and the structure of a representative product, (3RS)-4-(2-allyl-3,5-dimethylphenyl)-1-benzyl-3-phenylpiperazine-2,5-dione." Acta Crystallographica Section C Structural Chemistry 74, no. 2 (2018): 159–65. http://dx.doi.org/10.1107/s2053229618000037.

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A versatile synthesis of multiply substituted cyclic dipeptides has been designed, based on the stepwise construction of the piperazine-2,5-dione ring using molecular fragments from four different precursor molecules. Starting from substituted 2-allylanilines, reaction with methyl 2-bromo-2-phenylacetate yields the corresponding methyl 2-(2-allylanilino)-2-phenylacetates, which react with haloacetyl chlorides to give methyl 2-[N-(2-allylphenyl)-2-haloacetamido]-2-phenylacetates, which then undergo ring closure with benzylamine to yield the corresponding cyclic dipeptides of type 4-(2-allylphen

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8

Lee, Boeun, Michelle Taylor, Suzy A. Griffin, et al. "Evaluation of Substituted N-Phenylpiperazine Analogs as D3 vs. D2 Dopamine Receptor Subtype Selective Ligands." Molecules 26, no. 11 (2021): 3182. http://dx.doi.org/10.3390/molecules26113182.

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N-phenylpiperazine analogs can bind selectively to the D3 versus the D2 dopamine receptor subtype despite the fact that these two D2-like dopamine receptor subtypes exhibit substantial amino acid sequence homology. The binding for a number of these receptor subtype selective compounds was found to be consistent with their ability to bind at the D3 dopamine receptor subtype in a bitopic manner. In this study, a series of the 3-thiophenephenyl and 4-thiazolylphenyl fluoride substituted N-phenylpiperazine analogs were evaluated. Compound 6a was found to bind at the human D3 receptor with nanomola

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9

Malík, Ivan, Marián Bukovský, Fils Andriamainty, and Jana Gališinová. "Antimicrobial activity of meta-alkoxyphenylcarbamates containing substituted N-phenylpiperazine fragment." Brazilian Journal of Microbiology 43, no. 3 (2012): 959–65. http://dx.doi.org/10.1590/s1517-83822012000300016.

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10

Gallicchio, Steven N., and Ian M. Bell. "Convenient synthesis of 1,3-substituted-6-phenylpiperazin-2-ones." Tetrahedron Letters 50, no. 27 (2009): 3817–19. http://dx.doi.org/10.1016/j.tetlet.2009.04.036.

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11

Glase, Shelly A., Hyacinth C. Akunne, Lynn M. Georgic, et al. "Substituted [(4-Phenylpiperazinyl)- methyl]benzamides: Selective Dopamine D4Agonists." Journal of Medicinal Chemistry 40, no. 12 (1997): 1771–72. http://dx.doi.org/10.1021/jm970021c.

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12

Hanson, Robert N. "Radioiodinated I -substituted-4-phenylpiperazines as potential brain imaging agents." International Journal of Nuclear Medicine and Biology 12, no. 4 (1985): 315–20. http://dx.doi.org/10.1016/0047-0740(85)90186-x.

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13

Malík, Ivan, Marián Bukovský, Fils Andriamainty, and Jana Galiinová. "Antimicrobial effect of para-alkoxyphenylcarbamic acid esters containing substituted N-phenylpiperazine moiety." Brazilian Journal of Microbiology 44, no. 2 (2013): 457–63. http://dx.doi.org/10.1590/s1517-83822013000200018.

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14

Patel, Nalini, Vaishali Karkhanis, and Pinkal Patel. "Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 353–58. http://dx.doi.org/10.22270/jddt.v9i4-s.3327.

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Some 1-((4-methylpiperazin-1yl)methyl)-1H-benzo[d]imidazole & 1-((4-phenylpiperazin-1yl)methyl)-1H-benzo[d]imidazole derivatives were synthesized through reaction of 1-substituted piperazines with different benzimidazole derivatives in methanol yielded the corresponding mannich bases (42-a to 42-i). All the synthesized compounds were elucidated by IR, 1H NMR and MASS spectroscopy. They were tested for anti-inflammatory activity using in-vivo (Carrageenan- induced rat paw edema model) method at a dose of 50mg/kg. result showed that compounds 42-c, 42-d and 42-h were found to be most potent

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15

DUKIĆ, SLADJANA, SLADJANA KOSTIĆ-RAJAČIĆ, DEANA DRAGOVIĆ, VUKIC ŠOŠKIĆ, and JELENA JOKSIMOVIĆ. "Synthesis of Several Substituted Phenylpiperazines Behaving as Mixed D2/5HT1A Ligands." Journal of Pharmacy and Pharmacology 49, no. 10 (1997): 1036–41. http://dx.doi.org/10.1111/j.2042-7158.1997.tb06037.x.

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16

Martin, Gregory E., Robert J. Elgin, James M. Kesslick, et al. "Block of conditioned avoidance responding in the rat by substituted phenylpiperazines." European Journal of Pharmacology 156, no. 2 (1988): 223–29. http://dx.doi.org/10.1016/0014-2999(88)90325-1.

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17

Pospisilova, Sarka, Pavlina Marvanova, Jakub Treml, et al. "Activity of N-Phenylpiperazine Derivatives Against Bacterial and Fungal Pathogens." Current Protein & Peptide Science 20, no. 11 (2019): 1119–29. http://dx.doi.org/10.2174/1389203720666190913114041.

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Background: As the bacterial resistance to antibacterial chemotherapeutics is one of the greatest problems in modern medicine, efforts are made to develop new antimicrobial drugs. Compounds with a piperazine ring have proved to be promising agents against various pathogens. Objective: The aim of the study was to prepare a series of new N-phenylpiperazines and determine their activity against various pathogens. Method: Target compounds were prepared by multi-step synthesis starting from an appropriate substituted acid to an oxirane intermediate reacting with 1-(4-nitrophenyl)piperazine. Lipophi

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18

Konstantinov, Igor, Konstantin Bukhryakov, Yuri Gezentsvey, and Mikhail Krasavin. "ChemInform Abstract: Practical Method for Parallel Synthesis of Diversely Substituted 1-Phenylpiperazines." ChemInform 43, no. 17 (2012): no. http://dx.doi.org/10.1002/chin.201217179.

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19

Galmier, M. J., J. F. Pognat, C. Lartigue-Mattei, et al. "Biotransformation study of para-substituted phenylpiperazines in Beagle dogs by gas chromatography-mass spectrometry." Xenobiotica 21, no. 10 (1991): 1371–84. http://dx.doi.org/10.3109/00498259109043212.

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20

Pettersson, Fredrik, Peder Svensson, Susanna Waters, Nicholas Waters, and Clas Sonesson. "Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines." European Journal of Medicinal Chemistry 62 (April 2013): 241–55. http://dx.doi.org/10.1016/j.ejmech.2012.12.031.

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21

Mouhtaram, M., L. Jung та J. F. Stambach. "Novel synthesis of substituted c-phenylpiperazines by addition of benzylamine or methylamine to β-nitrostyrene". Tetrahedron 49, № 7 (1993): 1391–400. http://dx.doi.org/10.1016/s0040-4020(01)90191-7.

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22

Biyiklioglu, Zekeriya, and Hakan Alp. "Electropolymerizable peripherally tetra-{2-[3-(diethylamino)phenoxy]ethoxy} substituted as well as axially (4-phenylpiperazin-1-yl)propanoxy-disubstituted silicon phthalocyanines and their electrochemistry." Dalton Transactions 44, no. 43 (2015): 18993–99. http://dx.doi.org/10.1039/c5dt03421c.

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23

Mensonides-Harsema, Marguérite M., Yi Liao, Henning Böttcher, et al. "Synthesis and in Vitro and in Vivo Functional Studies ofOrtho-Substituted Phenylpiperazine andN-Substituted 4-N-(o-Methoxyphenyl)aminopiperidine Analogues of WAY100635." Journal of Medicinal Chemistry 43, no. 3 (2000): 432–39. http://dx.doi.org/10.1021/jm991088y.

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24

Sichrovska, Lubica Havranova, Ivan Malik, Eva Sedlarova, et al. "Prediction of blood-brain barrier penetration of meta-/para-Alkoxyphenylcarbamic acid Esters bearing substituted N-Phenylpiperazine fragment." Dhaka University Journal of Pharmaceutical Sciences 13, no. 1 (2015): 7–14. http://dx.doi.org/10.3329/dujps.v13i1.21854.

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The present study deals with blood-brain barrier (BBB) passive penetration of the substances labelled as 7a7d and chemically referred to as 1-[3-(Y-alkoxyphenylcarbamoyloxy)-2-hydroxypropyl]-4-(2-methylphenyl) piperazinium chlorides. Following their chemical structures, they could be classified as prospective ?-/?-adrenoceptor blockers. Such groups are known, among others, by their adverse reactions on central nervous system due to their transport across the BBB. The lipophilicity as the main parameter of the BBB permeability predictions is presented by the values of partition coefficient whi

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25

Al-Alshaikh, Monirah A., Aamal A. Al-Mutairi, Hazem A. Ghabbour, Ali A. El-Emam, Mohammed S. M. Abdelbaky, and Santiago Garcia-Granda. "Syntheses and crystal structures of two adamantyl-substituted 1,2,4-triazole-5-thione N-Mannich bases." Acta Crystallographica Section E Crystallographic Communications 73, no. 8 (2017): 1135–39. http://dx.doi.org/10.1107/s2056989017009756.

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In the title N-Mannich bases, 3-(adamantan-1-yl)-4-(4-fluorophenyl)-1-[(4-phenylpiperazin-1-yl)methyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione (C29H34FN5S) (I), and 3-(adamantan-1-yl)-4-(4-fluorophenyl)-1-{[4-(2-methoxyphenyl)piperazin-1-yl]-methyl}-4,5-dihydro-1H-1,2,4-triazole-5-thione (C30H36FN5OS) (II), fluorophenyl, adamantane and piperazine moieties are linked to a planar triazole ring. There is an additional phenyl ring on the piperazine ring in (I) and a methoxyphenyl ring in (II). In compound (I), the fluorophenyl and phenyl rings are inclined to the triazole ring by 86.55 (13) and 60.

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26

MOUHTARAM, M., L. JUNG та J. F. STAMBACH. "ChemInform Abstract: Novel Synthesis of Substituted C-Phenylpiperazines by Addition of Benzylamine or Methylamine to β-Nitrostyrene." ChemInform 24, № 25 (2010): no. http://dx.doi.org/10.1002/chin.199325188.

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27

Martin, Gregory E., Robert J. Elgin, Joanne R. Mathiasen, et al. "Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy." Journal of Medicinal Chemistry 32, no. 5 (1989): 1052–56. http://dx.doi.org/10.1021/jm00125a020.

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28

Mensonides-Harsema, Marguerite M., Yi Liao, Henning Boettcher, et al. "ChemInform Abstract: Synthesis and in vitro and in vivo Functional Studies of ortho-Substituted Phenylpiperazine and N-Substituted 4-N-(o-Methoxyphenyl)aminopiperidine Analogues of WAY100635." ChemInform 31, no. 20 (2010): no. http://dx.doi.org/10.1002/chin.200020136.

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29

Perumgani, Pullaiah C., Balaswamy Kodicherla, Mohan Rao Mandapati, and Sai Prathima Parvathaneni. "Suzuki-Miyaura cross-coupling for efficient synthesis of aryl-substituted N-heteroarenes catalyzed by recyclable N-phenylpiperazine-Palladium(II) complex." Inorganica Chimica Acta 477 (May 2018): 227–32. http://dx.doi.org/10.1016/j.ica.2018.03.006.

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30

Pettersson, Fredrik, Peder Svensson, Susanna Waters, Nicholas Waters, and Clas Sonesson. "Synthesis and Evaluation of a Set of Para-Substituted 4-Phenylpiperidines and 4-Phenylpiperazines as Monoamine Oxidase (MAO) Inhibitors." Journal of Medicinal Chemistry 55, no. 7 (2012): 3242–49. http://dx.doi.org/10.1021/jm201692d.

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31

Lagu, Bharat, Dake Tian, Dhanapalan Nagarathnam та ін. "Design and Synthesis of Novel α1aAdrenoceptor-Selective Antagonists. 3. Approaches To Eliminate Opioid Agonist Metabolites by Using Substituted Phenylpiperazine Side Chains". Journal of Medicinal Chemistry 42, № 23 (1999): 4794–803. http://dx.doi.org/10.1021/jm990202+.

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32

Karthikeyan, S., T. M. Rajendiran, R. Kannappan, R. Mahalakshmy, R. Venkatesan, and P. Sambasiva Rao. "Synthesis and physiochemical studies on binuclear Cu(II) complexes derived from 2,6-[(N-phenylpiperazin-1-yl)methyl]-4-substituted phenols." Journal of Chemical Sciences 113, no. 4 (2001): 245–56. http://dx.doi.org/10.1007/bf02708644.

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33

Koryakova, Angela G., Yan A. Ivanenkov, Elena A. Ryzhova, et al. "Novel aryl and heteroaryl substituted N-[3-(4-phenylpiperazin-1-yl)propyl]-1,2,4-oxadiazole-5-carboxamides as selective GSK-3 inhibitors." Bioorganic & Medicinal Chemistry Letters 18, no. 12 (2008): 3661–66. http://dx.doi.org/10.1016/j.bmcl.2007.11.121.

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34

Moloney, Gerard P., Agatha Garavelas, Graeme R. Martin, Miles Maxwell, and Robert C. Glen. "Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor." European Journal of Medicinal Chemistry 39, no. 4 (2004): 305–21. http://dx.doi.org/10.1016/j.ejmech.2003.12.008.

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35

Malawska, B., та L. Antkiewicz-Michaluk. "ChemInform Abstract: Synthesis, Physicochemical Properties, Anticonvulsant Activities, and Voltage-Sensitive Calcium Channels Affinity of N-Substituted Amides of α-(4-Phenylpiperazino)-GABA. Part 3. Search for New Anticonvulsant Compounds." ChemInform 30, № 32 (2010): no. http://dx.doi.org/10.1002/chin.199932165.

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36

Preti, Delia, Pier Giovanni Baraldi, Giulia Saponaro, et al. "Design, Synthesis, and Biological Evaluation of Novel 2-((2-(4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5′-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A2A Adenosine Receptor." Journal of Medicinal Chemistry 58, no. 7 (2015): 3253–67. http://dx.doi.org/10.1021/acs.jmedchem.5b00215.

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37

AGARWAL, S. K., A. K. SAXENA, P. C. JAIN, N. ANAND, R. C. SRIMAL, and B. N. DHAWAN. "ChemInform Abstract: Synthesis and Pharmacological Activities of 1-(2,4-Disubstituted Phenoxy)-3-(N1-(N4-arylpiperazinyl))propanes and 1-(4-Chlorobenzoyl)-3- substituted-6-methoxy-2-(4-(3-N1-(N4-phenylpiperazinyl)propoxy)phenyl) indoles." ChemInform 22, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.199129201.

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38

Khalil, Abd, Moged Berghot, and Moustafa Gouda. "Synthesis and study of some new N-substituted imide derivatives as potential antibacterial agents." Chemical Papers 64, no. 5 (2010). http://dx.doi.org/10.2478/s11696-010-0049-z.

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AbstractDibenzobarrelene (I) was used as a starting compound for the synthesis of some new 3a,4,9,9a-tetrahydro-4,9-[1,2]benzeno-1H-benzo[f]isoindole-1,3(2H)-diones, N-substituted with: 4-toluenesulfonyloxy, III; butoxy, IV; 3-bromopropoxy, V; 3-(4-phenylpiperazin-1-yl)propoxy, VI; 3-chloro-3-oxopropyl, VIII; 3-(4-phenylpiperazin-1-yl)-3-oxopropyl, IXa; 3-(4-methylpiperazin-1-yl)-3-oxopropyl, IXb; 3-oxo-3-(piperidin-1-yl)propyl, X; 3-morpholino-3-oxopropyl, XI; 3-phenylamino-3-oxopropyl, XII; 2-acetylaminoethyl, XIV; 2-aminoethyl, XV, and 2-acetoxyethyl, XVI. Newly synthesized compounds were c

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39

Gallicchio, Steven N., and Ian M. Bell. "ChemInform Abstract: Convenient Synthesis of 1,3-Substituted-6-phenylpiperazin-2-ones." ChemInform 40, no. 41 (2009). http://dx.doi.org/10.1002/chin.200941174.

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40

MORLACCHI, F., G. TRAPANI, V. LOSACCO, and D. ARMENISE. "ChemInform Abstract: Synthesis and Antibacterial Activity of N-Substituted Phenylpiperidines and Phenylpiperazines." Chemischer Informationsdienst 17, no. 5 (1986). http://dx.doi.org/10.1002/chin.198605193.

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41

SUESSE, M., R. SKUBATZ, D. DEMUS, and H. ZASCHKE. "ChemInform Abstract: Liquid-Crystalline Heterocycloalkanes. Part 2. Sytheses and Liquid-Crystalline Properties of Substituted 1-Phenylpiperazines." ChemInform 18, no. 8 (1987). http://dx.doi.org/10.1002/chin.198708236.

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42

Huang, Junjun, and Mu Yuan. "Separation of substituted phenylpiperazine derivatives with immobilized polysaccharide-based chiral stationary phases by supercritical and subcritical fluid chromatography." Journal of Chinese Pharmaceutical Sciences 22, no. 3 (2013). http://dx.doi.org/10.5246/jcps.2013.02.035.

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43

Huang, Junjun, and Mu Yuan. "Separation of substituted phenylpiperazine derivatives with immobilized polysaccharide-based chiral stationary phases by supercritical and subcritical fluid chromatography." Journal of Chinese Pharmaceutical Sciences, 2013. http://dx.doi.org/10.5246/jcps.2013.03.035.

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44

Moloney, Gerard P., Agatha Garavelas, Craeme R. Martin, Miles Maxwell, and Robert C. Glen. "Synthesis and Serotonergic Activity of Variously Substituted (3-Amido)phenylpiperazine Derivatives and Benzothiophene-4-piperazine Derivatives: Novel Antagonists for the Vascular 5-HT1B Receptor." ChemInform 35, no. 36 (2004). http://dx.doi.org/10.1002/chin.200436154.

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45

Malík, I., E. Sedlárová, F. Andriamainty, J. Gališinová та J. Csöllei. "Relationship between chemical structure, binding affinity and selectivity towards α1-adrenoceptors in the group of substituted n-phenylpiperazines. Part 2*. compounds containing ethane-1,2-diyl connecting chain". Acta Facultatis Pharmaceuticae Universitatis Comenianae 58, № 1 (2011). http://dx.doi.org/10.2478/v10219-011-0005-1.

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