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Relevant bibliographies by topics / Phthalazine

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Dissertations / Theses
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Academic literature on the topic 'Phthalazine'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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Journal articles on the topic "Phthalazine"

1

Mourad, Asmaa Kamal, Abdelmoneim Abdelsalam Makhlouf, Ahmed Yousef Soliman, and Samar Ahmed Mohamed. "Phthalazines and phthalazine hybrids as antimicrobial agents: Synthesis and biological evaluation." Journal of Chemical Research 44, no. 1-2 (2019): 31–41. http://dx.doi.org/10.1177/1747519819883840.

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Phthalazine and phthalazinone derivatives are important owing to their significant biological activities and pharmacological properties. Herein, a benzoic acid derivative (2), a benzoxazin-1-one derivative (3), and an oxophthalazin-2(1 H)-yl)acetohydrazide (13) are utilized as precursors to construct a novel series of phthalazinones bearing various valuable functional groups in excellent yields via several simple and promising approaches. Finally, the antimicrobial activity of the newly synthesized phthalazines is screened against different microbial strains; namely, Gram-negative and Gram-pos

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Panoutsopoulos, Georgios I., and Christine Beedham. "Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin." Acta Biochimica Polonica 51, no. 4 (2004): 943–51. https://doi.org/10.18388/abp.2004_3527.

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The enzymes aldehyde oxidase and xanthine oxidase catalyze the oxidation of a wide range of N-heterocycles and aldehydes. These enzymes are widely known for their role in the metabolism of N-heterocyclic xenobiotics where they provide a protective barrier by aiding in the detoxification of ingested nitrogen-containing heterocycles. Isovanillin has been shown to inhibit the metabolism of aromatic aldehydes by aldehyde oxidase, but its inhibition towards the heterocyclic compounds has not been studied. The present investigation examines the oxidation of phthalazine in the absence and in the pres

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3

Wasfy, A. A. F. "Fused Heterocycles. Part I. Synthesis of Some Annelated 1,2,4-Triazole Systems from [4-(1H-Benzimidazol-2-yl)-Phthalazin-1-Yl]Hydrazine." Journal of Chemical Research 2003, no. 8 (2003): 457–58. http://dx.doi.org/10.3184/030823403103174786.

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Substituted 6-(1 H-benzimidazol-2-yl)-[1,2,4]triazolo[3,4- a]phthalazine derivatives containing alkyl, aryl, hydroxyl, mercapto, methylthio and formyl substituents at position 3 have been synthesised. Di-[6-(1 H-benzimidazol-2-yl)-3-[1,2,4]triazolo[3,4- a]phthalazin-3-yl]alkanes have been obtained by the use of dicarboxylic acids or their esters in the above condensations. Methylation reactions of the triazolo-phthalazine system are reported.

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Xu, Jing. "Research on Synthesis of Triazine Ring and its Isomerization." Applied Mechanics and Materials 686 (October 2014): 26–30. http://dx.doi.org/10.4028/www.scientific.net/amm.686.26.

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This paper designed and synthesized a series of different chain length of phthalonitrile-terminated oligo (phthalazinone imide), it has good water solubility, and can be under normal atmospheric pressure to form the s-triazine rings-containing thermosetting oligo (phthalazine imide). Compared with the traditional thermosetting resin, the resin has the advantages of high temperature resistance, high strength, flame retardant, resistance to chemical corrosion.

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Mohammad, Asif. "Pharmacological activities of various phthalazine and phthalazinone derivatives." Chemistry International 5, no. 1 (2019): 97–108. https://doi.org/10.5281/zenodo.1475407.

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Various pthalazine derivatives have been synthesized and tested for their diverse biological activities. Pthalazine derivatives have been exhibited pharmacological activities like antitumor, PARP-1 inhibitors, antimicrobial, antivirus, antihistamine-H1, antiallergic rhinitis, antifungal, anti-inflammatory, anti-proliferative, COX-2 inhibitor, LOX-5 inhibitor, antidiabetes, and other biological activities like imaging agent. Pthalazine derivatives were also used as agrochemicals and chemicals. Various synthetic aspects indicate that pthalazines derivatives are easy to synthesize which can produ

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Plasseraud, Laurent, Hélène Cattey та Philippe Richard. "Self-assembly Through Non-coordinating Intermolecular Forces, Part 2 [1]. Synthesis, Crystal Structure and Packing of [Cu2(μ-phthalazine)3(phthalazine)2][CF3SO3]2". Zeitschrift für Naturforschung B 63, № 10 (2008): 1169–74. http://dx.doi.org/10.1515/znb-2008-1005.

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Abstract Treatment of the copper(I) trifluoromethanesulphonate toluene complex {[Cu(CF3SO3)]2 · C6H5Me} (1) with phthalazine (phtz, C8H6N2) in dichloromethane-acetonitrile solution yielded, via the bis(acetonitrile)tris(μ-phthalazine)dicopper(I) trifluoromethanesulphonate intermediate (2), the novel bis(phthalazine)tris(μ-phthalazine)dicopper(I) trifluoromethanesulphonate salt (3). Compound 3 was completely characterised and the molecular structure determined by single-crystal X-ray diffraction. Complex 3 crystallises in the monoclinic system, space group C2/c, with a = 26.9527(10), b = 10.955

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7

Habibi, Davood, Nosratollah Mahmoodi, and Omid Marvi. "Montmorillonite K-10 clay as reusable heterogeneous catalyst for the microwave-mediated solventless synthesis of phthalazinetetraones." Canadian Journal of Chemistry 85, no. 2 (2007): 81–84. http://dx.doi.org/10.1139/v06-189.

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Different phthalazino[2,3-b]phthalazine-5,7,12,14-tetraones were synthesized in a simple and environmentally benign method from the reaction of some phthalic anhydrides with semicarbazide or thiosemicarbazide using montmorillonite K-10 clay as solid heterogeneous acidic catalyst and microwaves under solvent-free conditions in good yields and short reaction times. The present method has many obvious advantages compared with those reported in the literature, including high efficiency, higher yield, operational simplicity, environmental benignity, and the possibility of recycling the solid clay.

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Habibi, Davood, Nosratollah Mahmoudi, and Omid Marvi. "Green Procedure for the Synthesis of Phthalazino[2,3‐b]phthalazine‐5,7,12,14‐tetraones." Synthetic Communications 37, no. 18 (2007): 3165–71. http://dx.doi.org/10.1080/00397910701545247.

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9

Cai, Mingjian. "5-Bromophthalazine hemihydrate." Acta Crystallographica Section E Structure Reports Online 68, no. 8 (2012): o2421. http://dx.doi.org/10.1107/s1600536812030358.

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The title compound, C8H5BrN2·0.5H2O, is a phthalazine derivative synthesized from 3-bromobenzene-1,2-dicarbaldehyde and hydrazine. The molecule is essentially planar, the deviation from the mean plane of the phthalazine ring being 0.015 (3) Å. The O atom of the solvent water molecule is situated on a twofold rotation axis. In the crystal, O—H...N hydrogen bonds and short N...Br [2.980 (3) Å] contacts lead to the formation of a two-dimensional network parallel to (101).

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Soliman, Saied M., Raghdaa A. Massoud, Hessa H. Al-Rasheed, and Ayman El-Faham. "Molecular and Supramolecular Structures of Cd(II) Complexes with Hydralazine-Based Ligands; A New Example for Cyclization of Hydrazonophthalazine to Triazolophthalazine." Crystals 11, no. 7 (2021): 823. http://dx.doi.org/10.3390/cryst11070823.

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Molecular and supramolecular structures of two polymeric and one trinuclear Cd(II) complex with hydralazine-type ligands were presented. Self-assembly of E-1-(2-(thiophen-2-ylmethylene)hydrazinyl)phthalazine (HL) and CdCl2 gave the 1D coordination polymer [Cd(H2L)Cl3]n*H2O, 1, in which the Cd(II) ion is hexa-coordinated with one cationic monodentate ligand (H2L+) and five chloride ions, two of them acting as connectors between Cd(II) centers, leading to the formation of a 1D coordination polymer along the a-direction. Using DFT calculations, the cationic ligand (H2L+) could be described as a p

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Dissertations / Theses on the topic "Phthalazine"

1

Sheppard, Christopher Lorenzo. "Magnetostructural correlations in polynuclear complexes of phthalazine-based tetra- and hexadentate ligands." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ34227.pdf.

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Li, Jiyang [Verfasser]. "Investigation of Phthalazine, Quinazoline and Pyrimidine Derivatives as ABCG2 Inhibitors / Jiyang Li." Bonn : Universitäts- und Landesbibliothek Bonn, 2018. http://d-nb.info/1167857135/34.

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Kuzelka, Jane 1975. "Modeling the active sites of diiron and dicopper metalloproteins with napthyridine-, phthalazine-, and diethynylbenzene-based ligands." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/30016.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2003.<br>Vita.<br>Includes bibliographical references.<br>Chapter 1. Bio-Inspired Reactions of Diiron Centers with Dioxygen A variety of biological systems employ carboxylate-bridged diiron centers to achieve substrate oxidation using dioxygen, and numerous small molecule model compounds have been synthesized in order to mimic this chemistry in the absence of a protein scaffold. In this introductory chapter, a brief overview is presented of ligand systems that have been used to prepare diiron complexes, and the subsequ

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Alzahrani, Nada Saleh. "The Synthesis and Characterization of the Bis-Substituted Phthalazine Using Bis-Substituted Isoindoline as Starting Material and Their Metals Complexes &The Synthesis and Charectrization of the Schiff Base Ligands with a Variety of Metals." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1408102563.

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Houghton, Ralph Warren. "Synthesis of 1-substituted phenyl phthalazines." Scholarly Commons, 1990. https://scholarlycommons.pacific.edu/uop_etds/2201.

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The purpose of this work was the preparation of a new class of arylhydrazone reagents. When combined with a mixture of ketones and aldehydes, these new reagents would give derivatives different from those given by current arylhydrazone reagents. These derivatives could be separated by crystallization or chromatography and could then be easily characterized by x-ray crystallography or nuclear magnetic resonance (NMR).

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Ragunathan, Ramanaranjinie. "Studies of certain benzimidazoles, phthalazines and phthalimides." Thesis, Brunel University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292494.

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Johnsen, Matthias. "Neue Antithrombotika mit Phthalazin- und Pyridazin-Partialstrukturen." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/257/index.html.

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Jožef, Mađari. "Sinteza, strukturna, fizičko-hemijska i biološka karakterizacija novih N-heterocikličnih liganada i njihovih kompleksa sa jonima prelaznih metala." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107656&source=NDLTD&language=en.

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Opisane  su  sinteze  novih  liganada  bis(ftalazin-1hidrazon)-2,6-diacetilpiridna  (Hz<sub>2</sub>DAP·2HCl),  bis(3-hlorpiridazin-6-hidrazon)-2,6-diacetilpiridina (Hp<sub>2</sub>DAP),  3-hlorpiridazin-6-hidrazon  di(2-piridil) ketona  (HpDPK),  ftalazin-1-hidrazon  di(2-piridil)ketona  (HzDPK)  i  ftalazin-1-hidrazon  piridin-2-karbaldehida  (HzPY).  Zajedničko  svojstvo  dobijenih liganada  je  &scaron;to  sadrže  piridinski  i  diazinski  prsten 

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Chang, Wen-Fu, and 張文福. "Phthalazine derivatives synthesize." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/37358420057208271610.

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碩士<br>國立中央大學<br>化學研究所<br>92<br>The heterocycles involving 1,4-dihydazinophthalazine (DHPH) as a building block have been paid considerable attention due to the significant biological applications. 1,4-dihydrazinophthalazine 1 reacted with 14、15 and 16. The ratio between 12 and 13, is dependent upon the pH of medium and temperature.1,4-dihydrazinophthalazine 1 reacted with aldehyde, followed by an oxidative cyclization to gave 22、28 and 29. When compound 29 was treated with 31 in ethanol under reflux for 12 h, it was also complex 32 .Upon irradiation with UV light, complex 32 changed color fr

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Hung, Cheng-Lung, and 洪正龍. "Synthesis and Application of Ruthenium Complex Dyes Containing 1-(pyridin-2-yl)phthalazine Derivatives for Dye-sensitized Solar Cells (DSSCs)." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/ynhygq.

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碩士<br>國立臺北科技大學<br>有機高分子研究所<br>97<br>Global environment concerns and the finite nature of fossil fuels have led to a growth of interest in the development of renewable energy. In order to maintain social and economic development, the solar energy is one of the best candidates of making a suitable transition to renewable fuels. Dye-sensitized solar cells (DSSCs) are currently attracting widespread interest for the conversion of sunlight into electricity because of their low cost and high efficiency. Charge separation is initiated at the dye, bound at the interface of an inorganic semiconductor l

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Books on the topic "Phthalazine"

1

Brown, D. J. Cinnolines and Phthalazines. John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0471744123.

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Ragunathan, Ramanaranjinie. Studies of certain benzimidazoles, phthalazines and phthalimides. Brunel University, 1991.

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3

Cinnolines and Phthalazines. Wiley & Sons Canada, Limited, John, 2005.

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Taylor, Edward C., Desmond J. Brown, and Jonathan A. Ellman. Cinnolines and Phthalazines, Supplement 2. Wiley & Sons, Incorporated, John, 2005.

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Cinnolines and phthalazines: Supplement 2. Wiley, 2005.

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6

Castle, Raymond N. Condensed Pyridazines Including Cinnolines and Phthalazines. Wiley & Sons, Incorporated, John, 2009.

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Taylor, Edward C., Desmond J. Brown, and Jonathan A. Ellman. Cinnolines and Phthalazines, Volume 64, Supplement 2. Wiley & Sons Australia, Limited, John, 2005.

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8

Simpson, J. C. Pyridazine and Pyrazine Rings : (Cinnolines, Phthalazines, and Quinoxalines). Wiley & Sons, Incorporated, John, 2009.

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9

Castle, Raymond N. Chemistry of Heterocyclic Compounds, Condensed Pyridazines Including Cinnolines and Phthalazines. Wiley & Sons, Incorporated, John, 2008.

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10

Taylor, Edward C., Peter Wipf, and Desmond J. Brown. Cinnolines and Phthalazines: Chemistry of Heterocyclic Compounds, Supplement II (Chemistry of Heterocyclic Compounds: A Series Of Monographs). Wiley-Interscience, 2005.

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Book chapters on the topic "Phthalazine"

1

Horkel, Ernst. "Metalation of Pyridazine, Cinnoline, and Phthalazine." In Topics in Heterocyclic Chemistry. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/7081_2012_97.

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2

Winkelmann, Jochen. "Diffusion coefficient of 1,4-diphenylbenzo[g]phthalazine in tetrahydro-furan-d8." In Diffusion in Gases, Liquids and Electrolytes. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-540-73735-3_976.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of hexanuclear copper(II) chloro complex with glycerol phthalazine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54237-8_611.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of hexanuclear copper(II) bromo complex with glycerol phthalazine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54237-8_612.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of hexanuclear copper(II) nitrato complex with glycerol phthalazine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54237-8_613.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of octanuclear copper(II) chloro complex with pentaerythritol phthalazine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54237-8_616.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of octanuclear copper(II) bromo complex with pentaerythritol phthalazine." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54237-8_617.

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Patel, Natu R. "Phthalazines." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186978.ch2.

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9

Winkelmann, Jochen. "Diffusion coefficient of 1,4-diphenylbenzo[g]phthalazine ion(2-) in tetrahydro-furan-d8." In Diffusion in Gases, Liquids and Electrolytes. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-540-73735-3_977.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of tetranuclear copper(II) complex with novel dendritic poly(phthalazine) ligand." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54237-8_596.

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Conference papers on the topic "Phthalazine"

1

Yan, Qingling, Hongyuan Chen, Yiling Zhang, Jinyun Zhao, and Xigao Jian. "Novel Poly(Phthalazinone Ether Sulfone Ketone) Heat Resistant Coating1." In CORROSION 2008. NACE International, 2008. https://doi.org/10.5006/c2008-08048.

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Abstract Novel poly(phthalazinone ether sulfone ketone) (PPESK) synthesized in our laboratory, has shown good solubility and very high glass transition temperature (Tg), in the range of 263±305℃, by the virtue of the introduction of twist non-coplanar phthalazinone moieties into the polymer’s backbone. The resin was dissolved in organic solvent, and baked to form varnish. The effects of polymers’ sulfone/ketone molar ratios (S/K) and intrinsic viscosity on the coating’s properties were studied, either. The result showed that the varnish has excellent adhesion to metal, impact resistance and fl

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2

Raposo, M., Ana Sampaio, and G. Kirsch. "Synthesis of 1-amino-4-(2´-thienyl)phthalazine Derivatives." In The 8th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2004. http://dx.doi.org/10.3390/ecsoc-8-01948.

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Cuba, Lidia, Ion Bulhac, and Paulina Bouros. "Synthesis and characterization of coordination compounds of Co(II) and mn(II) with n,n-heterocyclic ligand." In Conferința științifică națională cu participare internațională "Integrare prin cercetare și inovare", dedicată Zilei Internaționale a Științei pentru Pace și Dezvoltare. Moldova State University, 2025. https://doi.org/10.59295/spd2024n.77.

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Some coordination compounds of cobalt(II) and manganese(II) and N,N-heterocyclic ligand phthalazine are described. Complexes were obtained by the interaction of o-phthalaldehyde (DF), isoniazid (INh) and Co(NCS)2·3H2O or Mn(CCl3COO)2 (1:2:1), are studied by elemental analysis and IR spectroscopy. The molecular structure of Mn(II) complex has been determined by single crystal X-ray diffracton analysis.

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Raposo, M., and Sara Fernandes. "Synthesis and characterization of novel phthalazine based push-pull heterocyclic systems for DSSC." In The 19th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-a020.

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Raposo, M., and Sara Fernandes. "Synthesis and characterization of novel thienyl-phthalazine based heterocyclic systems functionalized with (bi)thiophene moieties." In The 21st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04797.

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Balewski, Łukasz, Jakub Kokoszka, Joanna Fedorowicz, et al. "Synthesis, Structure and Biological Activity of Novel 4,5-dihydro-1H-imidazol-2-yl-phthalazine Derivatives and Their Copper(II) Complexes." In ECMC 2022. MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13272.

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Andrejevic, Tina, Dusan Milivojevic, Darko Ašanin, et al. "DNA/BSA binding affinities and <em>in vivo</em> toxicity of dinuclear silver(I) complexes with phthalazine." In 6th International Electronic Conference on Medicinal Chemistry. MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07371.

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Chen, Tai-Lin, Vicky Jain, Yi-Wen Lin, Tsann-Long Su, and Te-Chang Lee. "Abstract 3852: Development of1,2-bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine hybrids as potent anticancer agents to small cell lung cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3852.

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Chen, Tai-Lin, Vicky Jain, Yi-Wen Lin, Tsann-Long Su, and Te-Chang Lee. "Abstract 3852: Development of1,2-bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine hybrids as potent anticancer agents to small cell lung cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3852.

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Chen, Tai-Lin, Vicky Jain, Anilkumar S. Patel, Yi-Wen Lin, Tsann-Long Su, and Te-Chang Lee. "Abstract A002: Discovery of bis(hydroxymethyl)benzopyrrolo[2,1-a]phthalazine derivatives as orally bioavailable antitumor agents with anti-angiogenic and DNA cross-linking activities." In Abstracts: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-a002.

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