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Dissertations / Theses on the topic 'Physiological barrier'

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1

Hom, Sharon. "Modulation of the Blood-Brain Barrier During Hypertension Development." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/196090.

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Hypertension is involved in the exacerbation of stroke. Increased blood-brain barrier (BBB) permeability and cerebral edema formation are potentially lethal complications of cerebral infarction. It is unclear how BBB tight junction (TJ), ion transporter, and protein kinase C (PKC) signaling pathway proteins critical for maintaining brain homeostasis contribute to cerebral infarction during hypertension development. The hypothesis of this study is that hypertension leads to molecular changes in the BBB which predispose the brain to increased cerebral infarct damage following ischemic stroke.
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2

Ho, Maureen. "The ecophysiology of coral reef macroalgae and their plasticity to environmental changes." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/406055.

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Macroalgae, or seaweeds, are photosynthetic primary producers found in marine, freshwater, and estuarine environments; however, most diversity is found in marine environments. Macroalgae consist of a diverse range of functional groups including filamentous, fleshy and encrusting, and calcareous crustose or non-crustose algae. The diversity and complexity of macroalgae serve different ecological roles and their physiological response under various environments will have implications on community assemblages and overall reef community structure. On coral reefs, changing environments continue to
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3

Petruschke, Charlotte [Verfasser]. "Cutin, wax and stomatal mutants of Arabidopsis thaliana: chemical and physiological analysis of the leaf barrier properties / Charlotte Petruschke." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1198933666/34.

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4

Thompson, Brandon. "Hypoxia/Reoxygenation Stress Modulates Atorvastatin Transport at the Blood-Brain Barrier: A Role for Organic Anion Transporting Polypeptide." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337292.

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Cerebral ischemia occurs when blood flow to the brain is insufficient to meet metabolic demand. This can result from cerebral artery occlusion that interrupts blood flow, limits CNS supply of oxygen and glucose, and causes an infarction/ischemic stroke. Ischemia initiates a cascade of molecular events in neurons and cerebrovascular endothelial cells including energy depletion, dissipation of ion gradients, calcium overload, excitotoxicity, oxidative stress, and accumulation of ions and fluid. Blood-brain barrier (BBB) disruption is associated with cerebral ischemia and leads to vasogenic edema
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5

Bergstrom, Ellie R. "Carbon physiological strategies across dominant Great Barrier Reef crustose coralline algae in the context of evolutionary history and global change." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/402735.

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Crustose coralline algae (CCA) are calcifying marine red macroalgae that play key ecological roles in building and cementing reef structures, and contribute significantly to the coastal marine carbon cycle. Anthropogenic global change is advancing rapidly and its two main threats in the marine realm, ocean acidification (OA) and ocean warming, have been empirically shown to impair the physiology of CCA. However, the presence of CCA in the geological record dates back to more than 180 million years ago, indicating that CCA have endured periods of substantial fluctuation in oceanic temperature a
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6

Griffin, Marley A. "A model for examining antinuclear antibody circulation and binding capabilities of human serum from systemic lupus erythematosus patients." Virtual Press, 2007. http://liblink.bsu.edu/uhtbin/catkey/1371840.

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Antinuclear antibodies (ANA) are used in screening and diagnosis of autoimmune connective tissue disorders including systemic lupus erythematosus (SLE). CNS related disorders are prevalent in SLE patients (–80%) and ANA binds specific sites within the brain. To investigate ANA infiltration across the blood-brain barrier (BBB), an ANA injectable Lewis rat model was created using 3 rat groups (saline, ANA, and ANA with histamine; since histamine promotes BBB permeability). ANA serum levels were tested for all three rat groups and rats injected with histamine demonstrated signs of histadelia. Bra
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7

Doo, Steve Shao-Jen. "Understanding the functional role of large benthic foraminifera on coral reefs in a changing climate." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16577.

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Concerns regarding the response of calcifying species in future warmer and more acidic oceans have been raised in many studies. In coral reefs, calcifiers such as large benthic foraminifera (LBFs) play an important role in carbon sequestration and generating carbonate sediments. This thesis documents the importance of LBFs in coral reef environments using satellite imagery in conjunction with ground-truthed photographs to characterize LBF habitats, and subsequently reef-scale biomass on a seasonal scale at One Tree Reef (OTR), Southern Great Barrier Reef. Based on previous models of entire ree
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8

Wolfe, Steven A. "Implementation of Spatial Learning Assays for Behavioral Assessment of Neuronal Pathology." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1278513916.

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9

Lindqvist, Mia. "Assessment of the permeability of physiological membranes : A. A study of Stichodactyla helianthus toxin’s potential to penetrate the buccal mucosa and - B. An investigation of the permeability alterations in the blood brain barrier associated with Alzheimer’s disease." Thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167399.

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A. A study of Stichodactyla helianthus toxin’s potential to penetrate the buccal mucosa Introduction:  Buccal mucosa is an alternative route for drug administration and has advantages over other conventional routes by avoiding both enzymes in the gastro intestinal system and the hepatic first passage mechanism. Stichodactyla helianthus toxin (ShK) is a peptide toxin that blocks potassium channels in T lymphocytes and could be a future treatment for autoimmune diseases when finding a suitable way of administration. Aim:  The purpose of this part of the study was to develop a robust and reproduc
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10

Cangin, Causenge. "Association of depression with anaerobic muscle strengthening activity, moderate intensity physical activity, long term lipophilic statin usage, and selected co-morbidity: NHANES (National Health and Nutrition Examination Survey) 1999-2012." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460067114.

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11

Kioulaphides, Sophia. "Development of a physiologically accurate 3D blood-brain barrier hydrogel model." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122083.

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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2019<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 38-39).<br>The blood-brain barrier (BBB) is a tightly interconnected network of cells that creates a semi-permeable barrier between the central nervous system and the rest of the human body, taking in nutrients and blocking/excreting waste
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12

Mleczko, Anna [Verfasser]. "Investigation of skin physiological parameters in term neonates and evaluation of the influence of bathing on skin barrier function in newborns during the first four weeks of life : Prospective examination of the following skin parameters: stratum corneum hydration, skin pH, transepidermal water loss and skin surface lipids / Anna Mleczko." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1023233398/34.

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13

Kumar, Swati Ashok. "Developing a physiologically relevant blood brain barrier model for the study of drug disposition in glioma." Thesis, University of Central Lancashire, 2015. http://clok.uclan.ac.uk/12873/.

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14

Holmes, Raymond. "Work participation specialists' experiences of barriers to customer services on physiological functioning at a Social Services department." Thesis, University of Phoenix, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10038733.

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<p> This qualitative phenomenological study using Moustakas&rsquo;s (1994) modified van Kaam methodology explored eight work participation specialists&rsquo; (WPS) experiences of barriers to customer services for their physiological functioning in Central Maryland&rsquo;s DSS region. The data were collected through face-to-face audio-recorded interviews. Interviews were transcribed and analyzed using NVivo (10). The Administration at this Social Service Agency was the primary theme in this study, which resulted in three subthemes including leadership, management, and policy.</p>
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15

Ball, Kathryn. "Physiologically based pharmacokinetic modelling of the central nervous system : strategies for drug development." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P630.

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Une étape critique au cours du développement de médicaments est la mesure ou la prédiction des concentrations du médicament dans un tissu cible, qui peuvent ensuite être liées à des mesures de leur efficacité ou leur toxicité. Les concentrations de médicaments ne pouvant être mesurées dans le cerveau humain, ils doivent être simulés ou prédits en utilisant des approches alternatives de modélisation. L'objectif de cette thèse est de développer in silico des approches de prédiction combinant à la fois des données précliniques in vitro et in vivo dans un modèle physiologique structuré, avec une s
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16

Chiu, Chi-Fen, and 邱祺芬. "The Mechanism of Zika Virus Crossing the Physiological Barrier." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/cqs66c.

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17

Beale, Michael P. "New Approaches to Analyze Sound Barrier Effectiveness." 2012. http://hdl.handle.net/1805/3240.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Highway noise can cause annoyance, affect sleep patterns, and reduce the property value for people in the proximity. Current methods for analyzing the effectiveness of sound barriers only take loudness into consideration. This paper introduces new methods that can be used to analyze the effectiveness of the sound barriers. Our approach uses psychoacoustic measures including sharpness, roughness, fluctuation, strength, and annoyance. Highway noise is non-stationary, therefore each of these metrics are calculated over a short time. Fin
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18

Kasper, Sabine Martin Jeanne B. Morandi Maria T. "The results of a barrier analysis on complementary feeding practices among mothers in the Central River Division of the Gambia." 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1444906.

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19

Bakalarz, Dominik. "Molecular mechanisms of novel carbon monoxide and hydrogen sulfide donors activity enhancing physiological gastric mucosal integrity against acute drug-induced gastrotoxicity." Praca doktorska, 2021. https://ruj.uj.edu.pl/xmlui/handle/item/288598.

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20

Schulze, Christine [Verfasser]. "Transport of metal oxide nanoparticles across the human air-blood barrier : interactions with physiologically relevant media and proteins / von Christine Schulze." 2010. http://d-nb.info/1010621416/34.

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21

Stewart-Knox, Barbara, S. Kuznesof, J. Robinson, et al. "Factors influencing European consumer uptake of personalised nutrition. Results of a qualitative analysis." 2013. http://hdl.handle.net/10454/6205.

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The aim of this research was to explore consumer perceptions of personalised nutrition and to compare these across three different levels of "medicalization": lifestyle assessment (no blood sampling); phenotypic assessment (blood sampling); genomic assessment (blood and buccal sampling). The protocol was developed from two pilot focus groups conducted in the UK. Two focus groups (one comprising only "older" individuals between 30 and 60 years old, the other of adults 18-65 yrs of age) were run in the UK, Spain, the Netherlands, Poland, Portugal, Ireland, Greece and Germany (N=16). The analysis
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