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Relevant bibliographies by topics / PIP5K1

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Academic literature on the topic 'PIP5K1'

Author: Grafiati

Published: 7 October 2023

Last updated: 31 July 2025

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Journal articles on the topic "PIP5K1"

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Kawase, Atsushi, Yuta Inoue, Miho Hirosoko, Yuka Sugihara, Hiroaki Shimada, and Masahiro Iwaki. "Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells." Journal of Pharmacy & Pharmaceutical Sciences 22 (November 19, 2019): 576–84. http://dx.doi.org/10.18433/jpps30444.

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Purpose: The plasma membrane localization and transport activity of multidrug resistance-associated protein 2 (MRP2/ABCC2) and P-glycoprotein (P-gp/ABCB1) efflux transporters are governed by transporter-associated proteins. Phosphatidylinositol 4,5-bisphosphate (PIP2) formed by phosphatidylinositol 4-phosphate 5-kinase type 1 (PIP5K1) activates the linker function of radixin for efflux transporters. Radixin is involved in the plasma membrane localization of efflux transporters. We examined whether PIP5K1 could be a target for the modulation of transporter activities in hepatocytes and cancer c

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Wright, Brittany D., Catherine Simpson, Michael Stashko, et al. "Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C." Journal of Biomolecular Screening 20, no. 5 (2014): 655–62. http://dx.doi.org/10.1177/1087057114564057.

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Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) regulate a variety of cellular processes, including signaling through G protein-coupled receptors (GPCRs), endocytosis, exocytosis, and cell migration. These lipid kinases synthesize phosphatidylinositol 4,5-bisphosphate (PIP2) from phosphatidylinositol 4-phosphate [PI(4)P]. Because small-molecule inhibitors of these lipid kinases did not exist, molecular and genetic approaches were predominantly used to study PIP5K1 regulation of these cellular processes. Moreover, standard radioisotope-based lipid kinase assays cannot be easily adapted for

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Wang, Yanfeng, Lurong Lian, Aae Suzuki, et al. "Loss of Individual PIP5KI Isoforms Demonstrate That Spatial PIP2 Synthesis Is Required for Platelet Second Messenger Formation & Integrity of the Actin Cytoskeleton." Blood 112, no. 11 (2008): 109. http://dx.doi.org/10.1182/blood.v112.11.109.109.

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Abstract Following thrombin stimulation, platelet PIP5KI synthesizes phosphatidylinositol 4,5-bisphosphate (PIP2), which can be hydrolyzed by phospholipase C to generate second messengers such as IP3. PIP2 also regulates cytoskeletal dynamics by directly interacting with actin-binding proteins. Three isoforms of PIP5KI (α, β, and γ) are all capable of phosphorylating PI4P to synthesize PIP2. However, these isoforms have different primary structures, expression levels in various tissues, and intracellular localization. We have generated and characterized murine lines lacking PIP5KIβ or PIP5KIγ,

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Padrón, David, Ying Jie Wang, Masaya Yamamoto, Helen Yin та Michael G. Roth. "Phosphatidylinositol phosphate 5-kinase Iβ recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis". Journal of Cell Biology 162, № 4 (2003): 693–701. http://dx.doi.org/10.1083/jcb.200302051.

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Overexpression of phosphatidylinositol phosphate 5-kinase (PIP5KI) isoforms α, β, or γ in CV-1 cells increased phosphatidylinositol 4,5-bisphosphate (PIP2) levels by 35, 180, and 0%, respectively. Endocytosis of transferrin receptors, association of AP-2 proteins with membranes, and the number of clathrin-coated pits at the plasma membrane increased when PIP2 increased. When expression of PIP5KIβ was inhibited with small interference RNA in HeLa cells, expression of PIP5KIα was also reduced slightly, but PIP5KIγ expression was increased. PIP2 levels and internalization of transferrin receptors

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Chen, Xinsheng, Yanfeng Wang, Tami L. Bach та ін. "Mice Lacking PIP5Kβ or PIP5Kγ Have Unique Cytoskeletal Changes within Their Megakaryocytes & Platelets." Blood 106, № 11 (2005): 380. http://dx.doi.org/10.1182/blood.v106.11.380.380.

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Abstract Phosphatidylinositol-4, 5-bisphosphate (PIP2) is vital for the signaling cascades that are critical for actin dynamics. Although all PIP5K isoforms (α , β , and γ ) synthesize PIP2 by phosphorylating PI4P, the isoforms have different primary structures, expression levels in various tissues, and intracellular localization. To test the hypothesis that the functions of these isoforms are also different, we have generated murine lines that contain null mutations in either of two platelet PIP5K isoforms, PIP5Kβ and PIP5Kγ . PIP5Kβ -null mice were born 42% less than anticipated by Mendelian

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Clarke, Jonathan H., Piers C. Emson та Robin F. Irvine. "Localization of phosphatidylinositol phosphate kinase IIγ in kidney to a membrane trafficking compartment within specialized cells of the nephron". American Journal of Physiology-Renal Physiology 295, № 5 (2008): F1422—F1430. http://dx.doi.org/10.1152/ajprenal.90310.2008.

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PIP4Ks (type II phosphatidylinositol 4-phosphate kinases) are phosphatidylinositol 5-phosphate (PtdIns5P) 4-kinases, believed primarily to regulate cellular PtdIns5P levels. In this study, we investigated the expression, localization, and associated biological activity of the least-studied PIP4K isoform, PIP4Kγ. Quantitative RT-PCR and in situ hybridization revealed that compared with PIP4Kα and PIP4Kβ, PIP4Kγ is expressed at exceptionally high levels in the kidney, especially the cortex and outer medulla. A specific antibody was raised to PIP4Kγ, and immunohistochemistry with this and with an

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Wang, Yanfeng, Aae Suzuki, Lurong Lian та ін. "Platelets Lacking PIP5KIγ Have Impaired Cytoskeletal Dynamics and Adhesion, but No Defect in Integrin Activation." Blood 114, № 22 (2009): 772. http://dx.doi.org/10.1182/blood.v114.22.772.772.

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Abstract Abstract 772 Following thrombin stimulation, platelet PIP5KI synthesizes phosphatidylinositol 4,5-bisphosphate (PIP2), which can be hydrolyzed by phospholipase C to generate second messengers such as IP3. PIP2 also regulates cytoskeletal dynamics by directly interacting with actin-binding proteins such as talin. Three isoforms of PIP5KI (α, β, and γ) are all capable of phosphorylating PI4P to synthesize PIP2. We have generated and characterized murine lines lacking individual PIP5KI isoforms. While mice lacking PIP5KIα and PIP5KIα have absent second messenger formation and partially i

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Khadka, Bijendra, and Radhey S. Gupta. "Novel Molecular Signatures in the PIP4K/PIP5K Family of Proteins Specific for Different Isozymes and Subfamilies Provide Important Insights into the Evolutionary Divergence of this Protein Family." Genes 10, no. 4 (2019): 312. http://dx.doi.org/10.3390/genes10040312.

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Members of the PIP4K/PIP5K family of proteins, which generate the highly important secondary messenger phosphatidylinositol-4,5-bisphosphate, play central roles in regulating diverse signaling pathways. In eukaryotic organisms, multiple isozymes and subfamilies of PIP4K/PIP5K proteins are found and it is of much interest to understand their evolution and species distribution and what unique molecular and biochemical characteristics distinguish specific isozymes and subfamilies of proteins. We report here the species distribution of different PIP4K/PIP5K family of proteins in eukaryotic organis

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Bultsma, Yvette, Willem-Jan Keune та Nullin Divecha. "PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα". Biochemical Journal 430, № 2 (2010): 223–35. http://dx.doi.org/10.1042/bj20100341.

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The β-isoform of PIP4K (PtdIns5P-4-kinase) regulates the levels of nuclear PtdIns5P, which in turn modulates the acetylation of the tumour suppressor p53. The crystal structure of PIP4Kβ demonstrated that it can form a homodimer with the two subunits arranged in opposite orientations. Using MS, isoform-specific antibodies against PIP4Ks, RNAi (RNA interference) suppression and overexpression studies, we show that PIP4Kβ interacts in vitro and in vivo with the PIP4Kα isoform. As the two isoforms phosphorylate the same substrate to generate the same product, the interaction could be considered t

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Drake, J. M., and J. Huang. "PIP5K1 inhibition as a therapeutic strategy for prostate cancer." Proceedings of the National Academy of Sciences 111, no. 35 (2014): 12578–79. http://dx.doi.org/10.1073/pnas.1413363111.

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Dissertations / Theses on the topic "PIP5K1"

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黒田, 凌. "シロイヌナズナにおけるPIP5K7,PIP5K8およびPIP5K9の機能解析". Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/264646.

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Gonzales, Baptiste. "Etudes des facteurs cellulaires et lipidiques déterminant la localisation du site d'assemblage et de bourgeonnement du VIH-1." Electronic Thesis or Diss., Tours, 2019. http://www.theses.fr/2019TOUR3811.

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La formation des particules du VIH-1 résulte de l'assemblage des précurseurs Gag sur le feuillet interne de la membrane plasmique (MP) des cellules infectées. Les protéines Gag sont spécifiquement adressées à la MP grâce à des interactions entre le domaine MA et le PI(4,5)P2. Cette étude décrit le rôle des phosphadidylinosito1-4-phosphate 5-kinase de type 1 (PIP5K1alpha, beta et sigma) au cours des étapes tardives du VIH-1 dans le modèle celllulaire HeLa. Nous avons démontré que la PIP5K1alpha est l'enzyme principalement impliquée dans la production du PI(4,5P2. En suivant le trafic de Gag à l

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Liu, Chen [Verfasser], and Anton [Akademischer Betreuer] Schäffner. "The PIP1 protein expression is positively regulated by PIP2;1 and PIP2;2 in Arabidopsis thaliana / Chen Liu. Betreuer: Anton Schäffner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1078852243/34.

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Champeyroux, Chloé. "Caractérisation fonctionnelle de protéines en interaction avec l'aquaporine PIP2;1." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT120.

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La conductivité hydraulique racinaire (Lpr) traduit la capacité de transport d’eau de la racine. Lors de son trajet du sol vers le xylème, l’eau diffuse au sein de l’apoplasme ou au travers des cellules (voie de cellule-à-cellule). Au niveau de l’endoderme, la diffusion apoplasmique de l’eau est bloquée par le cadre de Caspari et des lamelles de subérine. La voie de cellule-à-cellule dépend principalement de l’activité des aquaporines régulées en partie par des interactions protéiques. Ce travail caractérise de nouveaux interactants de l’aquaporine racinaire PIP2;1 : le récepteur kinase RKL1 e

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Kurenbach, Brigitta. "Konjugativer DNA-Transfer zwischen Gram-positiven und Gram-negativen Spezies: Transferkomponenten des Multiresistenzplasmids pIP501 aus Streptococcus agalactiae." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971485305.

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Toscano, Sarah. "Functional characterisation of PIP4K in Drosophila melanogaster." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609822.

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Tavelis, Christodoulos. "Investigating the potential role of PIP4Ks in PI3K/Akt signalling." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/investigating-the-potential-role-of-pip4ks-in-pi3kakt-signalling(e70d9473-5932-468a-bdad-01668a68db58).html.

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Class I phosphoinositide 3-kinases (PI3Ks) generate the essential lipid second messenger PtdIns(3,4,5)P3 which plays a key role in the regulation of numerous cellular processes including cell growth and survival, gene transcription, cytoskeletal organisation and glucose metabolism through its downstream effectors and in particular the serine/threonine protein kinase Akt. Therefore, the PI3K/Akt signalling plays a critical regulatory role in diverse cellular processes and its dysregulation is implicated in the pathogenesis of many human diseases including cancer and type 2 diabetes. Overexpress

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Jouette, Julie. "Phosphoinositides et contrôle de la polarité cellulaire : régulations croisées entre la PIP5K Skittles et les protéines de polarité PAR1 et PAR3." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC118.

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La polarité cellulaire est un processus fondamental qui contrôle les spécificités fonctionnelle et physiologique de la plupart des cellules eucaryotes. Cette asymétrie intracellulaire repose sur l’existence de compartiments membranaires distincts, à la fois dans leur composition en protéines mais également en phosphatidyl-inositols (PIs). Ainsi, la mise en place et le maintien de la localisation asymétrique de modules multi-protéiques associés notamment aux protéines PAR sont essentiels pour l’élaboration des domaines de polarité cellulaire. Durant ma thèse, j’ai étudié les relations entre les

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Gerth, Angela Katharina [Verfasser]. "Phosphoinositide im Kern pflanzlicher Zellen : Kernlokalisierung der ubiquitären PI4P 5-Kinase PIP5K2 und ihr Einfluss auf die Entwicklung von Arabidopsis thaliana / Angela Katharina Gerth." Halle, 2018. http://d-nb.info/1155760921/34.

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Othman, Arige. "Pharmacomodulation on the piperidinol skeleton: Synthesis of novel PIPD1 derivatives as Mycobacterium abscessus agents." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13396/.

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Mycobacterium abscessus (M. abscessus) is a rapidly growing mycobacterium which is able to generate different problems in human infections, such as chronic lung diseases, pulmonary diseases and skin infection. M. abscessus is considered as the first emergent opportunistic pathogen and the number of the infections due to this pathogen increases each year. Since the natural multidrug resistance and the absence of specific treatment to fight it, M. abscessus has become a serious problem of the public health. In this context, an original approach of a phenotypic screen was performed and allowed to

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Books on the topic "PIP5K1"

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Kadir, Tulus Handra. Teknik interlocking dalam gaya permainan talempong Minangkabau di Desa Kubang Pipik, Kecamatan Baso, Kabupaten Agam, Propinsi Sumatera Barat: Laporan penelitian. Universitas Negeri Padang, 2002.

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Book chapters on the topic "PIP5K1"

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Donato, Dominique M., Steven K. Hanks, Kenneth A. Jacobson, et al. "PIP5K2." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101045.

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Donato, Dominique M., Steven K. Hanks, Kenneth A. Jacobson, et al. "PIP4K." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101044.

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Mei, Yu. "Arabidopsis PIP5K2 Is Involved in Salt Tolerance." In Functional Characterization of Arabidopsis Phosphatidylinositol Monophosphate 5-kinase 2 in Lateral Root Development, Gravitropism and Salt Tolerance. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9373-5_5.

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Mei, Yu. "Structure and Expression Pattern Analysis of Arabidopsis PIP5K2." In Functional Characterization of Arabidopsis Phosphatidylinositol Monophosphate 5-kinase 2 in Lateral Root Development, Gravitropism and Salt Tolerance. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9373-5_2.

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Halstead, Jonathan R., Mireille H. Snel, Sarah Meeuws, David R. Jones, and Nullin Divecha. "Assaying Endogenous Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K) Activities." In Methods in Molecular Biology. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-115-8_25.

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Gonçalves, João, Helena Soares, Norman L. Eberhardt, et al. "Type II PIPK." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101423.

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Mei, Yu. "Arabidopsis PIP5K2 Is Involved in Lateral Root Development Through Regulating Auxin Accumulation." In Functional Characterization of Arabidopsis Phosphatidylinositol Monophosphate 5-kinase 2 in Lateral Root Development, Gravitropism and Salt Tolerance. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9373-5_3.

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Mei, Yu. "Arabidopsis PIP5K2 Is Involved in Root Gravitropism Through Regulation of Polar Auxin Transport." In Functional Characterization of Arabidopsis Phosphatidylinositol Monophosphate 5-kinase 2 in Lateral Root Development, Gravitropism and Salt Tolerance. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9373-5_4.

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"PIP5K2." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102917.

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"PIP4K2." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102916.

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Conference papers on the topic "PIP5K1"

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Barragán, Miguel Mateus, Miguel Antonio Manrique Rojas, and José Alexander Estevez Lizarazo. "FBE Test Protocol for Temperatures up to 150°C." In CORROSION 2012. NACE International, 2012. https://doi.org/10.5006/c2012-01535.

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Abstract The exploration and production of deeper oilfields over the past six years has demonstrated an increase in temperature of around 40°C, raising the pipelines temperature up to 120°C. It appears that operating temperatures will continue to increase. Steel pipelines for hydrocarbon transportation have always been protected from corrosion through a coating system. Fusion bonded epoxy coatings, in combination with cathodic protection have been established as the best protective option for many years. Nowadays, failure of FBE coating systems is a fact, due to the increase in temperature of

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El-Awaad, Ehab, Katja Strätker, Samer Haidar та ін. "Targeting lipid kinase PIP5K1α as a promising strategy for the treatment of castration-resistant prostate cancer". У 6th International Electronic Conference on Medicinal Chemistry. MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07466.

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Wu, Pingping, Yue Teng, Ning Gu, Kecen Lu, Huayun Zhu, and Yajing Wang. "PIP5KL1: A Novel Diagnostic and Prognostic Marker for Colorectal Cancer : A novel diagnostic and prognostic marker." In 2022 16th ICME International Conference on Complex Medical Engineering (CME). IEEE, 2022. http://dx.doi.org/10.1109/cme55444.2022.10063305.

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Ngo, U., Y. Shi, A. R. Charbit та ін. "IL-13 and IL-17A Activate β1 Integrins Through an NF-κB/Rho Kinase/PIP5K1γ Pathway to Enhance Force Transmission in Airway Smooth Muscle". У American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4337.

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