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Dissertations / Theses on the topic 'Piperidine'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Lewis, Neil. "Asymmetric piperidine synthesis." Thesis, University of Nottingham, 1995. http://eprints.nottingham.ac.uk/13293/.

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It has been demonstrated that bakers' yeast reduction of 1-tert-butyl-2-methyl 3-oxo-piperidine-1,2-dicarboxylate gives (2R, 3S), 1-tert-butyl-2-methyl 3-hydroxy-piperidine-1,2-dicarboxylate in 80% chemical yield with >99% d.e. and >97% e.e. Also bakers' yeast reduction of 1-tert-butyl-3-ethyl 4-oxo-piperidine-1,3-dicarboxylate gives (3R, 4S), 1-tert-butyl-3-ethyl4-hydroxy-piperidine-1,3-dicarboxylate in 74% chemical yield with >99% d.e. and >93% e.e. The optical purity and absolute configurations of the hydroxy-ester derivatives were determined by conversion into the corresponding chiral bis-

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2

Taylor, Sarah Alison. "Sulfur-mediated pyrrolidine and piperidine synthesis." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613286.

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3

Girling, Paul Ricardo. "Novel approaches to piperidine and hydropyridine derivatives." Thesis, Durham University, 2012. http://etheses.dur.ac.uk/6354/.

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Three new modes of reactivity are reported between the reaction of an imine, but-3-en-2-ones and a Lewis acid. These are formal [2+2+2]-, [1+2+1+2]- and [4+2]- cycloadditions, deriving 1,1'-(1,2-dihydropyridine-3,5-diyl)diethanones, 1,1'-(1,4-dihydropyridine-3,5-diyl)diethanones and piperidin-4-ones and respectively. The [2+2+2]- and [1+2+1+2]-cycloadditions proceed when R3 = LG (leaving group), with the [1+2+1+2]-pathway dominating when the imine is easily hydrolysed within the reaction conditions. When R3 ≠ LG, the cycloaddition proceeds through different [4+2]-mechanistic pathways, dependen

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4

Adams, David Roger. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Exeter, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236570.

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5

Mosts, R. C. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379495.

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6

Eskici, Mustafa. "Asymmetric piperidine synthesis via 1,3-cyclic sulfates." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368215.

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7

Williams, Jodi Thomas. "Stereoselective piperidine synthesis via ene and carbonyl ene cyclisations." Thesis, Oxford Brookes University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289247.

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8

Lenagh-Snow, Gabriel Matthew Jack. "The synthesis of azetidine and piperidine iminosugars from monosaccharides." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:207235d5-2ea5-4724-92fd-924fa0ccd4ed.

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Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which the endocyclic oxygen atom has been replaced with a basic nitrogen. A common affect of this atomic substitution is to bestow these compounds with the ability to inhibit various sugarprocessing enzymes; most significantly the glycosidases (glycoside hydrolases) which areintimately involved in a huge array of biological functions. Compounds which inhibit these enzymes concordantly possess much potential as medicinal agents for the treatment of a variety of diseases. Several iminosugars have alread

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9

Dumare, N. B. "Synthetic studies towards mitralactonine, pipecolic acid and piperidine alkaloids." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2013. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/1920.

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10

Abdelsalam, Mansour. "Synthesis of piperidines using organometallic chemistry." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/4069/.

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11

Adriaenssens, Louis. "Stereoselective synthesis of piperidines." Thesis, Connect to e-thesis to view edited abstract. Move to record for print version, 2008. http://theses.gla.ac.uk/49/.

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12

Woods, Gordon Alexander. "Synthetic approaches to functionalised piperidines." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:4c6fdb6c-c021-447c-8fc9-35241b552850.

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This thesis is concerned with the synthesis of functionalised piperidines. The piperidine unit is found in numerous alkaloids and other natural products, and has also been incorporated into synthetic compounds of significant therapeutic or strategic synthetic potential. Although numerous syntheses of individual piperidine compounds have been published, there are few general routes to this class of compounds, and there is therefore a need for such routes to be developed. Bicyclic lactams derived from (S)-pyroglutamic acid have been shown to be useful synthons in the synthesis of pyrrolidines. A

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13

Archibald, Glenn Philip. "Use of novel nitrones in the synthesis of piperidine alkaloids." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/7127.

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The current study focused on development of a flexible synthetic strategy for the enantioselective preparation of 2-substituted-3-hydroxypiperidines utilising chiral 3-hydroxytetrahydropyridine N-oxides. Initial studies into the regio- and stereoselectivity of the 1,3-dipolar cycloaddition reaction between O-benzyl protected 3-hydroxytetrahydropyridine N-oxide 208 and a range of alkenes, proceeded with excellent exo/endo selectivity and near perfect regioselectivity. However the anti/syn selectivity was only moderately in favour of the desired anti-compounds. Further development has led to the

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14

Lonkar, P. S. "Pyrrolidine and piperidine nucleic acids: novel class of PNA analogues." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2004. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2879.

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15

Smith, Peter Duncan. "Synthesis of pipecolic acid derivatives via aza-Diels-Alder reactions." Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/552.

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16

Moore, Rebecca J. "Novel approaches to natural product synthesis using organozinc intermediates." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362516.

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17

Coggins, P. "Syntheses with 2-alkyl-2,3,4,5-tetrahydropyridine-1-oxides." Thesis, University of Exeter, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235969.

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18

Launay, Guillaume. "New approaches for C-F bond formation in organic chemistry." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/922.

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The importance of fluorinated organic molecules has grown over the last 50 years, particularly in the pharmaceutical and agrochemical industries. Therefore the development of new methods for fluorination is a very attractive research area. In Chapter 1, the properties and impact of the fluorine atom on organic molecules are overviewed. Existing electrophilic and nucleophilic fluorination methods are reviewed, and new developments in asymmetric fluorination are discussed. The emergence of the Prins fluorination reaction as a side product in BF₃.OEt₂ catalysed processes has been investigated as

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19

Gu, Xiaobo. "Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1111.

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Meperidine has been shown to have potent binding affinity for serotonin transporters (SERT) (Ki = 41 nM) and be an inhibitor of serotonin reuptake. Based upon these pharmacological results meperidine has been identified as a lead compound for the development of a novel class of serotonin-selective reuptake inhibitors (SSRIs). A variety of potent analogues of meperidine have been synthesized and evaluated in vitro as potential ligands for the serotonin transporter. Substitutions have been made on the aryl ring, the ester moiety and the piperidine nitrogen of meperidine. Potent analogues o

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20

Moraux, Thomas. "Synthesis and evaluation of α-fluoro analogues of capsaicin and 2-(aminomethyl)piperidine derivatives". Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2094.

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Chapter 1 gives an overview of the fluorine chemistry field, from its early developments to recent applications in medicinal chemistry. The development of asymmetric electrophilic or nucleophilic installation of fluorine in organic molecules is highlighten. Chapter 2 of this thesis discusses the enantioselective synthesis of α-fluoroamides. The study is applied to the synthesis of fluoroenantiomers of the bioactive molecule capsaicin and short-chain analogues. The biological activity of these compounds is assayed with the TRPV1 receptor. Results show that enantioselective α-fluoroamides (R)-97

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21

Pöschl, Anna. "Synthesis of novel piperidine building blocks and their use for the preparation of donepezil analogues." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/synthesis-of-novel-piperidine-building-blocks-and-their-use-for-the-preparation-of-donepezil-analogues(7bca2c61-fc01-4496-adb5-b42872749a34).html.

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The piperidine moiety is found in a vast number of bioactive natural products as well as numerous marketed drugs and is therefore an interesting target for synthetic modi cations. Synthetic piperidines currently in the clinic are predominantly limited to 1,4-disubstitution on the piperidine ring, hence it is important to develop strategies to access new drug candidates with diverse substitution con gurations on the ring. For this purpose, the aza-Michael reaction can be used as an atom-ecient method to access biologically important piperidines. An initial study into the utility of divinyl keto

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22

Chi, Feng. "Studies on the monoamine oxidase substrate/inactivator properties of piperidine analogs of the neurotoxin MPTP." Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-02132009-171404/.

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23

Upadhyay, P. K. "Development of new methodology using phosphorus ylides and enantioselective synthesis of pyrrolidine and piperidine alkaloids." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2009. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2768.

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24

Zziwa, Miriam C. N. "Fungicide resistance to morpholine and piperidine fungicides in barley and wheat powdery mildew, Erysiphe graminis D.C." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/27744.

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This work was carried out to study the sensitivity of barley and wheat powdery mildew (<I>Erysiphe graminis </I>f.sp. <I>hordei</I> and <I>E. graminis </I>f.sp. <I>tritici</I> respectively) to morpholine fungicides. Morpholine fungicides are classified as compounds with a low risk of resistance development. On the other hand, barley and wheat powdery mildews belong to the group of high risk fungi as far as development of fungicide resistance is concerned. Firstly, mildew isolates collected in the UK were assessed, over the period 1992 to 1995, for their sensitivity to three morpholine fungicid

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25

Hamidi, A. "Interaction between hindered piperidine light stabilisers and antioxidants in the thermal and photochemical oxidation of polyolefins." Thesis, Manchester Metropolitan University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378064.

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26

Pivatto, Marcos [UNESP]. "Estudo fitoquímico dos frutos de Senna spectabilis e análise comparativa do perfil alcaloídico de S. spectabilis e Cassia leptophylla." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/97994.

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Made available in DSpace on 2014-06-11T19:29:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-12-01Bitstream added on 2014-06-13T19:58:51Z : No. of bitstreams: 1 pivatto_m_me_araiq.pdf: 4500291 bytes, checksum: 41c36cab9b65c53f1fe92528b346a70e (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O presente trabalho objetivou o estudo fitoquímico dos frutos de Senna spectabilis e o estudo comparativo do perfil alcaloídico entre S. spectabilis e Cassia leptophylla, outra espécie vegetal relatada como fonte de alcalóides piperidínicos. O estudo fitoquímico do

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27

Mikó, Tibor. "N-Substituierte Piperidine und Analoga als Bausteine neuer Histamin-H3-Rezeptorantagonisten Synthese, Analytik, Pharmakologie und Struktur-Wirkungsbeziehungen /." [S.l.] : [s.n.], 2003. http://www.diss.fu-berlin.de/2003/226/index.html.

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28

Harkiss, Alexander Hugh. "Synthesis of novel fluorescent heterocyclic-derived α-amino acids and the total syntheses of piperidine natural products". Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8629/.

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During the course of this PhD, methodology for the synthesis of a series of novel, highly fluorescent pyridine-derived α-amino acids was developed. Enone-derived α-amino acids were subjected to an inverse electron demand hetero-Diels-Alder cycloaddition and aromatisation reaction, which led to a twelve-membered library of pyridine analogues. The optical properties of these compounds were analysed, with several exhibiting interesting fluorescent characteristics. One of the analogues was incorporated into a cell penetrating pentapeptide via solid phase peptide synthesis. The resulting hexapeptid

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29

Lansakara, Ashabha Indrashika. "Intramolecular cyclizations of alkyl pyridines & alkylidene dihydropyridines as synthetic intermediates toward synthesis of bis(piperidine) alkaloids." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/2105.

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Nature provides fascinating and complicated molecular structures which offer synthetic organic chemists amazing opportunities for the design of new strategies for natural product synthesis. Among these, nitrogen containing aza-heterocycles are of unparalleled importance in natural product, bioorganic, and medicinal chemistry. Pyridine and its derivatives in particular are the most common aza-heterocycles encountered in natural products, medicinal and materials chemistry. Pyridine derivatives also serve as precursors to fun

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30

JONAS, Hendrik. "Stereoselective Synthesis and Pharmacological Evaluation of 2,4-Bridged Piperidine Derivatives Designed to Activate the κ-Opioid Receptor". Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/518592.

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31

Pivatto, Marcos. "Estudo fitoquímico dos frutos de Senna spectabilis e análise comparativa do perfil alcaloídico de S. spectabilis e Cassia leptophylla /." Araraquara : [s.n.], 2005. http://hdl.handle.net/11449/97994.

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Resumo: O presente trabalho objetivou o estudo fitoquímico dos frutos de Senna spectabilis e o estudo comparativo do perfil alcaloídico entre S. spectabilis e Cassia leptophylla, outra espécie vegetal relatada como fonte de alcalóides piperidínicos. O estudo fitoquímico dos frutos de S. spectabilis forneceu 4 alcalóides piperidínicos: cassina (1), 3-O-acetil-cassina (20), 3-O-feruloil-cassina (18) e um estereoisômero da cassina (19), cujas configurações, ralativa e absoluta, ainda não foram determinadas. Dentre estes, somente a cassina (1) já era conhecida e foi isolada, em nosso grupo de pesq

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32

Kawamura, Meire Yasuko. "Emprego de diazocetonas α,β-insaturadas com geometria Z na direta construção de esqueletos indolizidínicos e piperidínicos funcionalizados." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-26082016-104019/.

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Pumiliotoxinas e seus congêneres são compostos isolados da pele de algumas espécies de sapos das famílias Dendrobatidae, Mantellidae, Bufonidae, e Myobatrachidae, apresentando interessantes propriedades farmacológicas. As pumiliotoxinas, embora tóxicas, apresentam consideráveis atividades cardiotônicas, assim, acredita-se que as homopumiliotoxinas, as desmetilpumiliotoxinas e as desidrodesmetilpumiliotoxinas também devam apresentar. Nesse sentido, a síntese destes compostos é de extrema valia para a comunidade científica. As diazocetonas α,β-insaturadas são intermediários promissore

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33

Silvestrini, Filippo. "A DFT study on chemodivergent preparation of piperidinic and morpholinic heterocycles." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20660/.

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The topic of this thesis is the DFT computational study of the mechanisms for the synthesis of chiral 3,4,5-trisubstituted piperidines and 2,6-disubstituted morpholines. The goal of this synthesis is to use, the same substrate containing two electrophilic sites: an α,β-unsaturated ester and a ketone, which evolve according to the nucleophile used (cyanide, phenyl sulfide) through different addition and cyclization reactions. A quaternary ammonium salt is used as a catalyst for these reactions, which leads to a diastereoisomeric excess both for the reactions of morpholine and piperidine product

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34

Dall'Aglio-Holvercem, Christiane Gonçalves. "Estudos populacionais e taxonomicos de formigas lava-pes, Solenopsis invicta (Hymenoptera: Formicidae) e da fenologia de seus parasitoides do genero Pseudacteon (Diptera: Phoridae)." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316308.

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Orientadores: Woodruff Whitman Benson, Jose Roberto Trigo<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-06T14:03:47Z (GMT). No. of bitstreams: 1 Dall'Aglio-Holvercem_ChristianeGoncalves_D.pdf: 1459643 bytes, checksum: 5ed521529fb7303e231df7d9f2ebbda3 (MD5) Previous issue date: 2006<br>Resumo: Este trabalho discute alguns aspectos da ecologia da formiga lava-pés Solenopsis invicta e seus parasitóides, as moscas do gênero Pseudacteon (familia Phoridae), e da taxonomia de S. invicta e S. saevissima, ambas nativas da América

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35

Truong, Yen Janette. "Discovery of Signal Suppression by N-hydroxy Piperidine to Enable Activity-based Sensing by Chemical Exchange Saturation Transfer Magnetic Resonance Imaging." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41091.

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Fluorescent probes are useful tools for studying chemical biology, available in a wide variety of colours and applicable to different biochemical processes. One of their hallmarks is the ability to tune their chemistry and allow them to selectively “turn on” in response to different biomolecular targets of interest. However, fluorescence is largely limited by shallow tissue depth of penetration. Magnetic resonance imaging (MRI) can overcome the depth of penetration limitations to better map these biochemical processes and mechanisms with contrast agents. Chemical exchange saturation transfer (

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36

CARRASCO, M. RENOM. "ASYMMETRIC HYDROGENATION OFINDUSTRIALLY RELEVANT SUBSTRATES." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/361390.

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This thesis is divided in two parts: In Part A (Chapters I to III), the studies on the asymmetric hydrogenation of substituted pyridines are described. These heteroaromatic compounds have proven very challenging to hydrogenate enantioselectively, however, the resulting chiral piperidines are of high industrial interest. In Chapter I, the state of the art and the mechanistic studies carried out on related N-heteroaromatic substrates are extensively discussed. In Chapter II, a new method for the asymmetric hydrogenation of 2-substitued pyridines is reported, together with complementary mechani

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37

Shayhidin, Elnur Elyar. "Evaluation of quinazolin-4-piperidine sulfamides as inhibitors of human NPP1 : relevance in the treatment of pathologic mineralization of valve interstitial cells." Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/26750.

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Le rétrécissement valvulaire aortique calcifié (RAC) est le trouble valvulaire le plus fréquent chez les personnes âgées des pays développés. La seule option de traitement possible le remplacement de la valve aortique. L'identification du rôle de l’enzyme ecto-nucleotidase NPP1 dans le processus de calcification suggère que cette enzyme pourrait être une cible potentielle pour le développement d'un inhibiteur pharmacologique contre la calcification de la valve aortique. Jusqu’à présent, les composés qui ont été développés en tant qu'inhibiteurs de NPP1 manquent de puissance et de spécificité.

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38

Micouin, Laurent. "Nouvelles méthodes de synthèse asymétrique à partir de lactames et amides chiraux dérivés du phénylglycinol." Paris 5, 1995. http://www.theses.fr/1995PA05P612.

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39

Vu, Van Ha. "Cyanation anodique et réaction de Fry modifiée : application à la synthèse stéréosélective d’alcaloïdes de la pipéridine." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S138/document.

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Les alcaloïdes de la pipéridine sont des composés présents à la fois dans le règne animal et végétal. L'approche générale que nous avons développée au cours de ce travail de thèse est basée sur l'utilisation de différents -aminonitriles qui ont été préparés soit par réduction de sels de pyridinium chiraux soit par cyanation anodique d'amines tertiaires dérivées de l'-phényl-éthylamine. Dans le premier cas, la modification de la réaction de Fry nous a permis de préparer les deux énantiomères de la coniine qui constitue l'agent toxique de la grande cigüe (Conium maculatum). En combinant cette mé

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40

Andersson, Hans. "Reaction between grignard reagents and heterocyclic N-oxides synthesis of substituted pyridines, piperidines and piperazines /." Doctoral thesis, Umeå : Department of Chemistry, Umeå University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25619.

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41

小倉, 博雄. "アルツハイマー病治療薬としてのpiperidine系cholinesterase阻害薬に関する薬理学的研究". 京都大学 (Kyoto University), 2001. http://hdl.handle.net/2433/150423.

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42

Pivatto, Marcos. "Espectrometria de massas aplicada aos estudos de biossíntese de alcalóides de Senna spectabilis /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/105776.

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Resumo: O presente trabalho teve como objetivo o estudo das vias biossintéticas dos alcalóides piperidínicos presentes em Senna spectabilis, motivado pela potente atividade anticolinesterásica e baixa toxicidade observada no derivado (-)-3-O-acetil-espectalina (15), eleito como composto líder para o desenvolvimento de fármacos anti-Alzheimer que estão em fase de estudos pré-clínicos. Por outro lado, o interesse acadêmico no conhecimento das vias metabólicas, pode levar a estudos futuros de engenharia genética para potencializar a produção desses metabólitos uma vez que a síntese é extremamente

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43

Oh, Seongho. "Optimization and extensions of the nucleophile catalyzed aldol-lactonization (NCAL) process for bicyclic beta-lactone synthesis: applications to piperidine, pyrrolidine, and gamma-lactam-fused beta-lactones." Texas A&M University, 2003. http://hdl.handle.net/1969.1/3961.

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The intramolecular nucleophile catalyzed aldol-lactonization (NCAL) process was optimized successfully. A variety of C9-acylated cinchona alkaloids were synthesized and used for NCAL reactions with non-activated aldehydes. New pyridinium salts, derivatives of MukaiyamaÂs reagent, led to marked improvements in efficiency for the catalytic, asymmetric NCAL process while maintaining high enantioselectivity. Larger scale versions of the catalytic, asymmetric NCAL reaction were also developed allowing practical access to chiral bicyclic b-lactones. As an extension of the intramolecular NCAL proces

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44

Pivatto, Marcos [UNESP]. "Espectrometria de massas aplicada aos estudos de biossíntese de alcalóides de Senna spectabilis." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/105776.

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Made available in DSpace on 2014-06-11T19:35:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-04-23Bitstream added on 2014-06-13T18:46:23Z : No. of bitstreams: 1 pivatto_m_dr_araiq.pdf: 3895401 bytes, checksum: 8f00934510e296fa101a80060a9db12a (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O presente trabalho teve como objetivo o estudo das vias biossintéticas dos alcalóides piperidínicos presentes em Senna spectabilis, motivado pela potente atividade anticolinesterásica e baixa toxicid

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Wang, I.-Hsiung 1950. "Kinetics Studies of Substituted Tungsten Carbonyl Complexes." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc330797/.

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Thermal reactions and flash photolysis are used to study the olefin bond-migration promoted by tungsten carbonyls. Substitution of piperidine (pip) by 2- allylphenyldiphenylphosphine (adpp) in the cis-(pip)(η^1- adpp)W(CO)-4 complex was investigated, and no olefin bond-migration was observed. This suggests that a vacant coordinated site adjacent to the coordinated olefin is an essential requirement for olefin bond rearrangement. The rates of olefin attack on the photogenerated coordinatively unsaturated species, cis-[(CB)(η^1-ol- P)W(CO)-4] (CB = chlorobenzene, p-ol = Ph-2P(CH-2)-3CH=CH-2; n

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Abe, Masahiro. "Etude de la réactivité d'ynolethers et ynamines arylogues pour des réactions d'hydroamination. Etude visant la synthèse énantiosélective de la molécule koumine." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR062.

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Le noyau pipéridine est un des motifs les plus courant dans les produits naturels et pharmaceutiques ce qui explique que la synthèse énantiosélective de piperidines polyfonctionnalisées soit un domaine particulièrement dynamique. De par sa capacité à associer une fonction amine à un groupement carbonylé, la réaction de Mannich est un outil efficace pour former une liaison C-C de manière énantiosélective tandis que la réaction d’hydroamination intramoléculaire d’alcynes est pratique pour construire des hétérocycles azotés par formation de liaisons C-N. Dans cette thèse, nous avons combiné ces d

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Khan, Abdul Majeed 1980. "Síntese e termoquímica de adutos de brometos de metais bivalentes com aminas hetrocíclicas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249123.

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Orientador: Pedro Oliver Dunstan Lozano<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-22T07:28:40Z (GMT). No. of bitstreams: 1 Khan_AbdulMajeed_D.pdf: 3004508 bytes, checksum: 1d8c778094bf0cb1b93fa7bf80e19074 (MD5) Previous issue date: 2013<br>Resumo: Os adutos MX2.nL (M = Mn, Fe, Co, Ni, Cu ou Zn, L = 3-cianopiridina, piperidina ou piperazaina, X = Br, n = 0,5, 0,75, 1, 1,5, 2 ou 4), foram sintetizados e caracterizados através de análise elementar, determinação de pontos de fusão, espectroscopia IV e eletrônica e análise

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Rosset, Isac George. "Diazocetonas α,β-insaturadas como reagentes multifuncionais: aplicação na síntese de alcaloides piperidínicos e pirrolidínicos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-20052015-101409/.

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p>O primeira parte do trabalho descreve a preparação de um novo reagente de olefinação de HWE para o preparo de diazocetonas α, β-insaturadas com geometria Z e aplicação na síntese de núcleos piperidínicos funcionalizados. Através da otimização da reação de HWE empregando o benzaldeído como aldeído padrão foi possível maximizar a obtenção do isômero Z desejado (92%, Z:E 9:1). As reações-chave para a formação dos núcleos piperidínicos foram a de olefinação de HWE utilizando amino-aldeídos, obtendo-se bons rendimentos e boa seletividade, seguida de uma reação de inserção N-H catalisad

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Turner, Ian. "Piperidines from tetrahydroimidazoles." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334848.

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Borhade, R. G. "Sugar nitrone based approaches for the total synthesis of biologically active polyhydroxylated pyrrolidine and piperidine alkaloides, studies towards the synthesis of leustroducsin-B and some Pd mediated reactions on sugar alkynes." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2007. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2575.

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