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Journal articles on the topic 'Piperidines'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Frolov, Nikita A., and Anatoly N. Vereshchagin. "Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications." International Journal of Molecular Sciences 24, no. 3 (2023): 2937. http://dx.doi.org/10.3390/ijms24032937.

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Piperidines are among the most important synthetic fragments for designing drugs and play a significant role in the pharmaceutical industry. Their derivatives are present in more than twenty classes of pharmaceuticals, as well as alkaloids. The current review summarizes recent scientific literature on intra- and intermolecular reactions leading to the formation of various piperidine derivatives: substituted piperidines, spiropiperidines, condensed piperidines, and piperidinones. Moreover, the pharmaceutical applications of synthetic and natural piperidines were covered, as well as the latest s

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2

K, Manjusha R., Shaheen Begum, Arifa Begum, and Bharathi K. "ANTIOXIDANT POTENTIAL OF PIPERIDINE CONTAINING COMPOUNDS-A SHORT REVIEW." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 66. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.26536.

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Piperidine is a saturated heterocyclic ring, considered as a privileged scaffold in view of its role in wide range of biological activities. Piperidine is good candidate molecule for obtaining potent antioxidant agents. The planar nature of this heterocyclic nucleus allows the introduction of substituent groups at different positions on the ring. In the present review, the antioxidant profile of piperidine containing compounds has been focused. The compounds were classified into naturally occurring piperidines, unsaturated piperidines, N-substituted piperidines, piperamides, piperanols, piperi

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3

Talbot, Eric. "Synthesis of Polyfunctionalised 2-Piperidinones Catalysed by Fe(acac)3." Synlett 30, no. 07 (2019): 821–26. http://dx.doi.org/10.1055/s-0037-1610700.

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Herein is reported the synthesis of polyfunctionalised piperidines and 2-piperidinones, through hydrogen atom transfer (HAT) chemistry catalysed by Fe(acac)3. The nature and substitution around the Michael acceptor, as well as the allylic amine, allowed access to all positions of the piperidine ring. The chemistry tolerates a range of different functionalities, allowing the investigation of new and diverse scaffolds.

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4

Kumar, Ashish, Anamika Sharma, Beatriz G. de la Torre та Fernando Albericio. "Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis". Molecules 24, № 21 (2019): 4004. http://dx.doi.org/10.3390/molecules24214004.

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GVL is a green solvent used in Fmoc-based solid-phase peptide synthesis. It is susceptible to ring opening in the presence of bases such as piperidines, which are used to remove the Fmoc protecting group. Here we studied the formation of the corresponding acyl piperidides by time-dependent monitoring using NMR. The results, corroborated by theoretical calculations, indicate that a solution of piperidines in GVL should be prepared daily for a better Fmoc removal.

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5

Guzmán-Rodríguez, Sergio, Jesús Chávez-Reyes, Priscila Vázquez-León, et al. "1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats." Pharmacology 106, no. 5-6 (2021): 305–15. http://dx.doi.org/10.1159/000513376.

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<b><i>Background:</i></b> Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. Piperidines are also produced in the human body, and their actions seem to be related to wakefulness/sleep and other cognitive phenomena. Piperidines have been minimally characterized for therapeutic applications. In this context, 1-Boc-piperidine-4-carboxaldehyde (1-Boc-piperidine) is a piperidine-derivative molecule with no mechanism of action reported, although its uses include the synthesis of GPR119 se

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6

Möhrle, H., and M. Jeandrée. "Chinazolinderivate durch Cyclodehydrierung von N-(2-substituierten Aryl)-Piperidinen / Quinazoline Derivatives by Cyclodehydrogenation of N-(2-Substituted Aryl)-Piperidines." Zeitschrift für Naturforschung B 54, no. 12 (1999): 1577–88. http://dx.doi.org/10.1515/znb-1999-1217.

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Dehydrogenation of the N-[2-(aminocarbonyl)phenyl]piperidines 1 -5 using Hg(II)-EDTA, generated the quinazolinones 6 -9 . Increasing size of the 4-substituent in the piperidine decreased the oxidation rate and the product yield.N-[2-(Hydroxyiminomethyl)phenyl]piperidines 18-22 showed a different behaviour. While 18 with H g(II)-EDTA in water produced the oxime lactam 24 in quantitative yield, the 4- substituted piperidines 19-21 caused not only a lower reaction rate but also an altered product pattern. The double dehydrogenation to lactams was reduced and the cyclic nitrones, formed by two ele

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7

Murthy Appala, Venkata Ramana, Kanaka Durga Bhavani Anagani, and Aparna Pasula. "Synthesis of New Piperidine based N(2)-Alkylated 1,2,3-Triazole Hybrids in Basic Medium." Asian Journal of Chemistry 35, no. 1 (2022): 212–16. http://dx.doi.org/10.14233/ajchem.2023.26906.

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The nucleophilic reaction of 1H-triazole derivatives with piperidines under basic conditions is the essential step in the synthesis of a new series of dibenzyl N(2)-C-linked triazolyl piperidines. The triazole derivative was synthesized via the CuAAc reaction of 1-phenylprop-2-yn-1-ol (1a-b) with azidomethyl pivalate. Compound 3a-b underwent dehydroxylation and deprotection reactions using TFA, triethyl silane and 1 M NaOH respectively, yielding monobenzyl 1H-1,2,3-triazole (4a-b). The N(2)-piperidinyltriazoles (6a-j) were synthesized in significant amounts by nucleophilically reacting 1H-tria

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8

Pelletier, Guillaume, Léa Constantineau-Forget, and André B. Charette. "Directed functionalization of 1,2-dihydropyridines: stereoselective synthesis of 2,6-disubstituted piperidines." Chem. Commun. 50, no. 52 (2014): 6883–85. http://dx.doi.org/10.1039/c4cc02220c.

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A practical and highly stereoselective approach to access 2,6-disubstituted piperidines using an amidine auxiliary is reported. These were reduced to the saturated piperidine rings with high diastereoselectivity.

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9

Tilve, Santosh, Sandesh Bugde, and Prajesh S.Volvoikar. "Protecting-Group-Directed Regio- and Stereoselective Oxymercuration–Demercuration: Synthesis of Piperidine Alkaloids Containing 1,2- and 1,3-Amino Alcohol Units." Synthesis 50, no. 05 (2017): 1113–22. http://dx.doi.org/10.1055/s-0036-1589523.

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An efficient synthesis of naturally occurring 1,2- and 1,3-amino alcohol unit containing 2-substituted piperidine alkaloids and their analogues has been developed from l-pipecolinic acid. The protocol describes the regio- and stereoselective oxymercuration–demercuration of 2-alkenyl piperidines based on protecting groups to give piperidine alkaloids as a key step.

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10

Song, Qiao, Sheng Wang, Xiangui Lei, Yan Liu, Xin Wen, and Zhouyu Wang. "One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines." Molecules 27, no. 15 (2022): 4698. http://dx.doi.org/10.3390/molecules27154698.

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Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts, highly toxic reaction reagents or hazardous reaction conditions. Herein, an efficient route from halogenated amides to piperidines and pyrrolidines was disclosed. In this method, amide activation, reduction of nitrile ions, and intramolecular nucleophilic substitution were integrated in a one-pot reaction. The reaction conditions were mild and no m

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11

López-Rodríguez, Alberto, Gema Domínguez, and Javier Pérez-Castells. "Synthesis of Novel Iminosugar Derivatives Based on a 2-Azabicyclo[4.1.0]heptane Skeleton." Synthesis 49, no. 20 (2017): 4606–12. http://dx.doi.org/10.1055/s-0036-1589109.

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Iminosugars are good starting points for the development of different kinds of drugs. Many are polyhydroxylated piperidines that behave as biomimetics of their corresponding pyranoses analogues. In the interaction with carbohydrate processing enzymes, selectivity is a crucial issue and the benefits of introducing a cyclopropane bridge in a piperidine structure is demonstrated. The synthesis of novel bicyclic piperidine-based iminosugars using a sulfur ylide cyclopropanation as the key synthetic step is described.

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12

Penjisevic, Jelena, Vladimir Sukalovic, Deana Andric, et al. "Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines." Journal of the Serbian Chemical Society 81, no. 4 (2016): 347–56. http://dx.doi.org/10.2298/jsc151021097p.

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A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological evaluation of the synthesized compounds was pointed out for seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl)piperidin-4-yl]methyl}piperazine had the highest affinity for the dopamine D2 receptor. For all seven selected compounds docking analysis was performed in order to establish their structure-to-activity relationship.

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13

Salgado, Mateo M., Alejandro Manchado, Carlos T. Nieto, David Díez, and Narciso M. Garrido. "Asymmetric Synthesis of 2,3,6-Trisubstituted Piperidines via Baylis–Hillman Adducts and Lithium Amide through Domino Reaction." Synlett 31, no. 06 (2019): 600–604. http://dx.doi.org/10.1055/s-0039-1690990.

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A convenient asymmetric synthesis of methyl (2S,3S,6R)-6-(4-fluorophenyl)-2-(4-hydroxyphenyl)-piperidine-3-carboxylate is described, starting from Baylis–Hillman adducts. The route involves a domino process: allylic acetate rearrangement, stereoselective Ireland–Claisen rearrangement and asymmetric Michael addition, which provides a δ-amino acid derivative with full stereochemical control. A subsequent chemoselective transformation of one of the side-chain groups allows an effective cyclization leading to biologically interesting polysubstituted piperidines in which the 2,6-aryl groups could b

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14

Jagtap, Shital, and Poonam Kaswan. "Synthesis and Antimicrobial Activity of Novel Sulfonyl Piperidine Carboxamide Derivatives Prepared from N-Boc-Piperidine-3-carboxylic Acid via Amide Coupling." Asian Journal of Chemistry 37, no. 6 (2025): 1315–21. https://doi.org/10.14233/ajchem.2025.33717.

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Piperidines serve as pivotal synthetic building blocks in the realm of drug design, with their derivatives forming essential parts of a wide range of drugs and alkaloids. This study presents a novel approach involving sulfonyl derivatives of piperidine-3-carboxylic acid, achieved through amide coupling with substituted sulphonyl chlorides. The synthesized compounds underwent characterization via IR, 1H NMR, 13C NMR and MS analyses. Specifically, a series of novel sulphonamides derived from 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid was synthesized, given the significance of sulphonami

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15

Liu, Lee Tai, Pao-Chiung Hong, Hsiang-Ling Huang, Shyh-Fong Chen, Chia-Lin Jeff Wang, and Yuh-Sheng Wen. "Asymmetric syntheses of trans-3,4-disubstituted 2-piperidinones and piperidines." Tetrahedron: Asymmetry 12, no. 3 (2001): 419–26. http://dx.doi.org/10.1016/s0957-4166(01)00069-6.

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16

Beng, Timothy K., Nathan Fox, Daniel P. Bassler, Amir Alwali, Kayla Sincavage та Ann Wens V. Silaire. "Trapping of carbolithiation-derived tertiary benzylic α-lithio piperidines with carbon electrophiles: Controlling the formation of α-amino quaternary and vicinal stereocenters". Organic & Biomolecular Chemistry 13, № 32 (2015): 8647–51. http://dx.doi.org/10.1039/c5ob01371b.

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The interception of carbolithiation-derived tertiary benzylic α-lithio piperidines with carbon electrophiles has led to the diastereoselective synthesis of vicinally functionalized piperidines bearing α-amino quaternary stereocenters.

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17

Wang, Fang, Xiaoli Liu, and Lei Wang. "Visible-light-induced C(sp3)–H functionalizations of piperidines to 3,3-dichloro-2-hydroxy-piperidines with N-chlorosuccinimide." Organic & Biomolecular Chemistry 19, no. 27 (2021): 6141–46. http://dx.doi.org/10.1039/d1ob00868d.

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18

Buffat, Maxime G. P. "Synthesis of piperidines." Tetrahedron 60, no. 8 (2004): 1701–29. http://dx.doi.org/10.1016/j.tet.2003.11.043.

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19

Šilhánková, Alexandra, Karel Šindelář, Karel Dobrovský, Ivan Krejčí, Jarmila Hodková, and Zdeněk Polívka. "Synthesis of New L-Proline Amides with Anticonvulsive Effect." Collection of Czechoslovak Chemical Communications 61, no. 7 (1996): 1085–92. http://dx.doi.org/10.1135/cccc19961085.

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Series of heterocyclic L-proline amides were prepared from BOC-L-proline and heterocyclic amines (mostly substituted piperazines and morpholines) via active ester with hydroxysuccinimide. 4-(4-Fluorobenzoyl)piperidine afforded L-proline 4-(4-(4-(4-fluorobenzoyl)piperidin-1-yl)benzoyl)piperidine (7b) simultaneously with expected L-proline 4-(4-fluorobenzoyl)piperidide (7a). D-Proline N-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)amide (2) was prepared starting from D-proline. The amides were tested by methods of biochemical and behavioural pharmacology.

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20

Kantlehner, Willi, Markus Vettel, and Bernhard Eppinger. "Orthoamide und Iminiumsalze, LXXVI [1]. Ein weiterer Beitrag zur Chemie der Trialkoxyacetonitrile/ Orthoamides and Iminium Salts LXXVI [1]. A Further Contribution to the Chemistry of Trialkoxyacetonitriles." Zeitschrift für Naturforschung B 67, no. 4 (2012): 373–88. http://dx.doi.org/10.1515/znb-2012-0412.

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An improved procedure for the preparation of trimethoxyacetonitrile (3a) starting from trichloroacetonitrile and sodium methanolate is described. Carbanions, obtained by the action of sodium hydride on nitriles, ethyl acetate and methylketones, react with trialkoxyacetonitriles 3 to give α- imino-orthocarboxylic acid trialkylesters 12, 14 and 20, which form an equilibrium with the tautomeric enamines 13, 15 and 21. The enamines 21 react with N,N-dimethylformamide dimethylacetal (24) to give amidines 25 which are cyclized to pyridinium salts 28 and 29 on treatment with benzyl bromide and acetyl

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21

Akhmetova, Gulmira S., Ulzhalgas B. Issayeva, Kaldybay D. Praliyev, et al. "Search for Antiviral Preparations in Series of New Derivatives of N-Substituted Piperidines." Molecules 30, no. 12 (2025): 2540. https://doi.org/10.3390/molecules30122540.

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Cyanohydrin synthesis, as the simplest preparative method for introducing a carboxyl group into a piperidine molecule, has been used to obtain potentially biologically active piperidinecarboxylic acids, which have alkyl and arylalkyl radicals at the nitrogen atom of the piperidine ring. Hydrochlorides of cyclopropanecarboxylic acid esters based on piperidinecarboxylic acids, as well as hydrochlorides of fluorobenzoic acid esters of N-substituted piperidines, have been synthesized. The purpose of this study was to search for antiviral drugs among new piperidine derivatives. The structure of the

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22

Beng, Timothy K., Hironori Takeuchi, Manuel Weber та Richmond Sarpong. "Stereocontrolled synthesis of vicinally functionalized piperidines by nucleophilic β-addition of alkyllithiums to α-aryl substituted piperidine enecarbamates". Chemical Communications 51, № 36 (2015): 7653–56. http://dx.doi.org/10.1039/c5cc01307k.

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23

Zanella, Giovanna, Martina Petrović, Dina Scarpi, Ernesto G. Occhiato, and Enrique Gómez-Bengoa. "Pentannulation of N-heterocycles by a tandem gold-catalyzed [3,3]-rearrangement/Nazarov reaction of propargyl ester derivatives: a computational study on the crucial role of the nitrogen atom." Beilstein Journal of Organic Chemistry 16 (December 15, 2020): 3059–68. http://dx.doi.org/10.3762/bjoc.16.255.

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The tandem gold(I)-catalyzed rearrangement/Nazarov reaction of enynyl acetates in which the double bond is embedded in a piperidine ring was computationally and experimentally studied. The theoretical calculations predict that the position of the propargylic acetate substituent has a great impact on the reactivity. In contrast to our previous successful cyclization of the 2-substituted substrates, where the nitrogen favors the formation of the cyclized final product, the substitution at position 3 was computed to have a deleterious effect on the electronic properties of the molecules, increasi

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24

Liu, Lee Tai, Pao-Chiung Hong, Hsiang-Ling Huang, Shyh-Fong Chen, Chia-Lin Jeff Wang, and Yuh-Sheng Wen. "ChemInform Abstract: Asymmetric Syntheses of trans-3,4-Disubstituted 2-Piperidinones and Piperidines." ChemInform 32, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.200130143.

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25

Compernolle, Frans, M. Ashty Saleh, Stefan Van den Branden, Suzanne Toppet, and Georges Hoornaert. "Regioselective oxidation of piperidine-3 derivatives: a synthetic route to 2,5-substituted piperidines." Journal of Organic Chemistry 56, no. 7 (1991): 2386–90. http://dx.doi.org/10.1021/jo00007a025.

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26

Laschat, Sabine, and Tim Dickner. "Stereoselective Synthesis of Piperidines." Synthesis 2000, no. 13 (2000): 1781–813. http://dx.doi.org/10.1055/s-2000-8218.

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27

Darout, Etzer, Kim F. McClure, and Vincent Mascitti. "Synthesis of spirofuranopyrimidine–piperidines." Tetrahedron 68, no. 24 (2012): 4596–99. http://dx.doi.org/10.1016/j.tet.2012.04.033.

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28

Borisova, T. N., A. V. Varalmov, N. D. Sergeeva, et al. "Pyrrolo[3,2-c]piperidines." Chemistry of Heterocyclic Compounds 23, no. 7 (1987): 799–803. http://dx.doi.org/10.1007/bf00475655.

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29

Butcher, J. W., and D. A. Claremon. "One-Pot Synthesis of Spiro Isochromane-3,3′-piperidines, -3,4′-piperidines and -3,3′-pyrrolidines." Synthesis 1993, no. 02 (1993): 211–12. http://dx.doi.org/10.1055/s-1993-25832.

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30

Möhrle, H., and M. Jeandrée. "Reaktionsbeteiligung elektrophiler Funktionen bei der Dehydrierung 4-substituierter Piperidine / Participation of Electrophilic Groups with the Dehydrogenation of 4-Substituted Piperidines." Zeitschrift für Naturforschung B 55, no. 1 (2000): 74–85. http://dx.doi.org/10.1515/znb-2000-0113.

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Dehydrogenation of 2-(1-piperidinyl)-benzaldehydes 1-3 using mercury(II)-EDTA gen erated the lactams 4-6, indicating a reversible reaction of a carbinolamine intermediate with the formyl group. The yields and oxidation rates decreased by 4-substitution in the piperidine moiety.The 2-(1-piperidinyl)-acetophenones 11, 16-19 showed a similar behavior with mercury(II)-EDTA but gave rise to a product pattern. The trans-benzoquinolizidones 12, 20, 23, 26, 29 resulted from the cyclic iminium compounds reacting with the acetyl group as nucleophile. By another oxidation these species were partially tr

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31

Dunbar, Christine R., and F. G. West. "Diastereoselective N-quaternization of piperidines." Canadian Journal of Chemistry 93, no. 4 (2015): 468–76. http://dx.doi.org/10.1139/cjc-2014-0423.

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The study of the N-quaternization of substituted piperidines has been mostly dormant for the last 40 years, despite the demand for ammonium salts as drugs, ionic liquids, chiral catalysts or ligands, phase transfer reagents, and reagents for the Stevens and Sommelet–Hauser rearrangements. In this perspective article, the complexity of this seemingly simple reaction is studied by a summary and analysis of literature experimental results. Computational methods are applied to various literature reactions as case studies.

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32

Šindelář, Karel, Marta Hrubantová, Emil Svátek, et al. "Potential antidepressants: 4-(Thioaryloxy)piperidines." Collection of Czechoslovak Chemical Communications 54, no. 8 (1989): 2240–47. http://dx.doi.org/10.1135/cccc19892240.

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Nucleophilic substitution reactions of a series of thio-substituted fluoroarenes with 1-methyl-4-piperidinol, 1-benzyl-4-piperidinol, and 1-methyl-4-phenyl-4-piperidinol in the presence of sodium hydride in dimethylformamide gave the title compounds V-XI and XIII. The salts of these bases were pharmacologically tested and salts of compounds V, XI, and XIII showed in behavioural tests properties which are indicative of antidepressant activity.

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33

Ma, Yao, Brian R. Lahue, Gerald W. Shipps, Jeseca Brookes, and Yaolin Wang. "Substituted piperidines as HDM2 inhibitors." Bioorganic & Medicinal Chemistry Letters 24, no. 4 (2014): 1026–30. http://dx.doi.org/10.1016/j.bmcl.2014.01.026.

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34

Bailey, Patrick D., Paula A. Millwood, and Peter D. Smith. "Asymmetric routes to substituted piperidines." Chemical Communications, no. 6 (1998): 633–40. http://dx.doi.org/10.1039/a709071d.

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35

Kemelbekov, Ulan, Vitaly Volynkin, Symbat Zhumakova, Kulpan Orynbassarova, Marina Papezhuk та Valentina Yu. "Comparative Analysis of the Structure and Pharmacological Properties of Some Piperidines and Host–Guest Complexes of β-Cyclodextrin". Molecules 29, № 5 (2024): 1098. http://dx.doi.org/10.3390/molecules29051098.

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Pain and anesthesia are a problem for all physicians. Scientists from different countries are constantly searching for new anesthetic agents and methods of general anesthesia. In anesthesiology, the role and importance of local anesthesia always remain topical. In the present work, a comparative analysis of the results of pharmacological studies on models of the conduction and terminal anesthesia, as well as acute toxicity studies of the inclusion complex of 1-methyl-4-ethynyl-4-hydroxypiperidine (MEP) with β-cyclodextrin, was carried out. A virtual screening and comparative analysis of pharma

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36

COMPERNOLLE, F., M. A. SALEH, S. VAN DEN BRANDEN, S. TOPPET, and G. HOORNAERT. "ChemInform Abstract: Regioselective Oxidation of Piperidine-3 Derivatives: A Synthetic Route to 2,5-Substituted Piperidines." ChemInform 22, no. 34 (2010): no. http://dx.doi.org/10.1002/chin.199134175.

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37

Pedersen, Christian Marcus, and Mikael Bols. "On the nature of the electronic effect of multiple hydroxyl groups in the 6-membered ring – the effects are additive but steric hindrance plays a role too." Organic & Biomolecular Chemistry 15, no. 5 (2017): 1164–73. http://dx.doi.org/10.1039/c6ob02427k.

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38

Le Guen, Clothilde, Teresa Mena-Barragán, Carmen Ortiz Mellet, David Gueyrard, Emmanuel Pfund та Thierry Lequeux. "Fluorinated hydroxypiperidines as selective β-glucosidase inhibitors". Organic & Biomolecular Chemistry 13, № 21 (2015): 5983–96. http://dx.doi.org/10.1039/c5ob00721f.

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39

Barnes, Korry L., Kelly Chen, Vincent J. Catalano, and Christopher S. Jeffrey. "New building blocks for iminosugars: a concise synthesis of polyhydroxylated N-alkoxypiperidines through an intramolecular azepine ring contraction." Organic Chemistry Frontiers 2, no. 5 (2015): 497–501. http://dx.doi.org/10.1039/c4qo00330f.

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40

BUTCHER, J. W., and D. A. CLAREMON. "ChemInform Abstract: One-Pot Synthesis of Spiro Isochromane-3,3′-piperidines, -3,4′- piperidines, and -3,3′-pyrrolidines." ChemInform 24, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.199325176.

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41

Herold, Sebastian, Daniel Bafaluy, and Kilian Muñiz. "Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines." Green Chemistry 20, no. 14 (2018): 3191–96. http://dx.doi.org/10.1039/c8gc01411f.

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42

Fu, Zhiqiang, Lili Yang, Dongru Sun, et al. "Coupled electron and proton transfer in the piperidine drug metabolism pathway by the active species of cytochromes P450." Dalton Transactions 49, no. 32 (2020): 11099–107. http://dx.doi.org/10.1039/c9dt03056e.

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43

Basirat, Narjes, Seyed Sajad Sajadikhah, and Abdolkarim Zare. "Multi-component synthesis of piperidines and dihydropyrrol-2-one derivatives catalyzed by a dual-functional ionic liquid." Journal of Chemical Research 44, no. 1-2 (2019): 20–24. http://dx.doi.org/10.1177/1747519819883881.

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N,N,N’, N’-tetramethyl- N,N’-bis(sulfo)ethane-1,2-diaminium mesylate ([TMBSED][OMs]2) was employed for the synthesis of piperidines and dihydropyrrol-2-ones via one-pot multi-component reactions in simple and green processes. This pseudo five-component reaction of aromatic aldehydes, anilines and alkyl acetoacetates was carried out under reflux conditions in ethanol to afford substituted piperidines. Also, dihydropyrrol-2-one derivatives were synthesized by means of four-component reactions of various amines, dialkyl acetylenedicarboxylates and formaldehyde in ethanol at room temperature. The

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Gautam, Lekh Nath, Yijin Su, Novruz G. Akhmedov, Jeffrey L. Petersen, and Xiaodong Shi. "Asymmetric synthesis of substituted NH-piperidines from chiral amines." Org. Biomol. Chem. 12, no. 33 (2014): 6384–88. http://dx.doi.org/10.1039/c4ob00657g.

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Muthusamy, Sengodagounder, Janagiraman Krishnamurthi, and Eringathodi Suresh. "Highly Regio- and Chemoselective Ring Opening of Oxa-Bridged Piperidinones toward Functionalized Furanones and Piperidines." Organic Letters 8, no. 22 (2006): 5101–4. http://dx.doi.org/10.1021/ol0620038.

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Chamorro‐Arenas, Delfino, Alejandro A. Nolasco‐Hernández, Lilia Fuentes, Leticia Quintero, and Fernando Sartillo‐Piscil. "Transition‐Metal‐Free Multiple Functionalization of Piperidines to 4‐Substituted and 3,4‐Disubstituted 2‐Piperidinones." Chemistry – A European Journal 26, no. 21 (2020): 4671–76. http://dx.doi.org/10.1002/chem.201905262.

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Philip, Rose Mary, G. S. Susan Treesa, Salim Saranya, and Gopinathan Anilkumar. "Applications of aryl-sulfinamides in the synthesis of N-heterocycles." RSC Advances 11, no. 33 (2021): 20591–600. http://dx.doi.org/10.1039/d1ra04099e.

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Petakamsetty, Ramu, Vipin Kumar Jain, Pankaj Kumar Majhi, and Ramesh Ramapanicker. "Divergent synthesis of various iminocyclitols from d-ribose." Organic & Biomolecular Chemistry 13, no. 31 (2015): 8512–23. http://dx.doi.org/10.1039/c5ob01042j.

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Yang, Yang. "Building polyfunctional piperidines: a stereoselective strategy of a three-component Mannich reaction inspired by biosynthesis and applications in the synthesis of natural alkaloids (+)-241D; (−)-241D; isosolenopsin A and (−)-epimyrtine." RSC Advances 5, no. 24 (2015): 18894–908. http://dx.doi.org/10.1039/c4ra14418j.

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Calosso, Michael, Mathieu Wagner, Thomas Gendrineau, Morgane Petit, Catherine Kadouri-Puchot, and Luc Dechoux. "Enantioselective Synthesis of 2,3-Disubstituted Piperidines." Letters in Organic Chemistry 4, no. 1 (2007): 4–6. http://dx.doi.org/10.2174/157017807780037487.

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