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Journal articles on the topic 'Player profiling'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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1

Spronck, Pieter, Iris Balemans, and Giel Van Lankveld. "Player Profiling with Fallout 3." Proceedings of the AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment 8, no. 1 (2021): 179–84. http://dx.doi.org/10.1609/aiide.v8i1.12523.

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In previous research we concluded that a personality profile, based on the Five Factor Model, can be constructed from observations of a player’s behavior in a module that we designed for Neverwinter Nights (Lankveld et al. 2011a). In the present research, we investigate whether we can do the same thing in an actual modern commercial video game, in this case the game Fallout 3. We stored automatic observations on 36 participants who played the introductory stages of Fallout 3. We then correlated these observations with the participants’ personality profiles, expressed by values for five persona

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2

Liu, Xuejie, Kathryn Merrick, and Hussein Abbass. "Toward Electroencephalographic Profiling of Player Motivation: A Survey." IEEE Transactions on Cognitive and Developmental Systems 10, no. 3 (2018): 499–513. http://dx.doi.org/10.1109/tcds.2017.2726083.

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Samborskii, Ivan, Aleksandr Farseev, Andrey Filchenkov, and Tat-Seng Chua. "A Whole New Ball Game: Harvesting Game Data for Player Profiling." Proceedings of the AAAI Conference on Artificial Intelligence 33 (July 17, 2019): 10025–26. http://dx.doi.org/10.1609/aaai.v33i01.330110025.

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Nowadays, video games play a very important role in human life and no longer purely associated with escapism or entertainment. In fact, gaming has become an essential part of our daily routines, which give rise to the exponential growth of various online game platforms. By participating in such platforms, individuals generate a multitude of game data points, which, for example, can be further used for automatic user profiling and recommendation applications. However, the literature on automatic learning from the game data is relatively sparse, which had inspired us to tackle the problem of pla

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Gautam, Amit Kumar. "Performance analysis and player profiling in kabaddi: A review." International Journal of Physical Education, Sports and Health 10, no. 6 (2023): 80–82. http://dx.doi.org/10.22271/kheljournal.2023.v10.i6b.3136.

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Canossa, Alessandro, Sasha Makarovych, Julian Togelius, and Anders Drachenn. "Like a DNA String: Sequence-Based Player Profiling in <i>Tom Clancy’s The Division</i>." Proceedings of the AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment 14, no. 1 (2018): 152–58. http://dx.doi.org/10.1609/aiide.v14i1.13049.

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In this paper we present an approach to using sequence analysis to model player behavior. This approach is designed to work in game development contexts, integrating production teams and delivering profiles that inform game design. We demonstrate the method via a case study of the game Tom Clancy’s The Division, which with its 20 million players represents a major current commercial title. The approach presented provides a mixed-methods framework, combining qualitative knowledge elicitation and workshops with large-scale telemetry analysis, using sequence mining and clustering to develop detai

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Williams, Jessica, Rhyse Bendell, Stephen M. Fiore, and Florian Jentsch. "Towards a Conceptual Framework of Comprehensive Video Game Player Profiles: Player Models, Mental Models, and Behavior Models." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 65, no. 1 (2021): 807–11. http://dx.doi.org/10.1177/1071181321651343.

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Current approaches to player profiling are limited in that they typically employ only a single one of numerous of available techniques shown to have utility for categorizing and explaining player behavior. We propose a more comprehensive Video Game Player Profile Framework that considers the demographic, psychographic, mental model, and behavioral modeling approaches shown to be effective for describing gamer populations. We suggest that our proposed approach can improve the efficacy of video game player profiles by grounding data-driven techniques in game analytics with the theoretical backin

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Boda, Márton Attila. "Avoiding Revenge Using Optimal Opponent Ranking Strategy in the Board Game Catan." International Journal of Gaming and Computer-Mediated Simulations 10, no. 2 (2018): 47–70. http://dx.doi.org/10.4018/ijgcms.2018040103.

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The study analyses the attitude of players in a board game called Catan. In Catan, we are basically handling the players as opponents, but this does not rule out the possibility of cooperation. In a game with three players, in order to increase the chances of winning, it is worth acting together against the lead player. Cooperation has several possible modalities. In the article, the focus is on blocking situations which can lead to revenge. The primary objectives of this study were to examine how different types of thinking can cause revenge situations and which are the successful strategies

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Seet May, Teng, Asmadi Ishak, and Mohd Azrul Anuar Zolkafi. "Sprint, Jump Performances, and Force-Velocity Profile in A Well-Trained Football Player: A Pilot Study." Journal of Social Science and Humanities 6, no. 6 (2023): 17–22. http://dx.doi.org/10.26666/rmp.jssh.2023.6.3.

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The objective of this pilot study is to find the well-trained football players’ force-velocity profile based on their sprint and jump performances. The participants of the study were boys (n=28), aged 19-21. To achieve the tasks, participants will be recruited to perform vertical squat jump tests against multiple external loads (vertical) by using the My jump 2 application and linear 30m sprints (horizontal) by using the My Sprint application to evaluate lower and upper limbs’ force-velocity profiles of the players. The vertical and horizontal force-velocity profiling (i.e., theoretical maxima

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Bostan, Barbaros, and Gokhan Sahin. "PLAYER PROFILING FOR INTERACTIVE STORYTELLING SYSTEMS: A C++ PATTERN MATCHING PROFILER." AJIT-e Online Academic Journal of Information Technology 6, no. 19 (2015): 23–40. http://dx.doi.org/10.5824/1309-1581.2015.2.002.x.

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10

Pocek, Suncica, Zoran Milosevic, Nemanja Lakicevic, et al. "Anthropometric Characteristics and Vertical Jump Abilities by Player Position and Performance Level of Junior Female Volleyball Players." International Journal of Environmental Research and Public Health 18, no. 16 (2021): 8377. http://dx.doi.org/10.3390/ijerph18168377.

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Although absolute jump heights should be considered an important factor in judging the performance requirements of volleyball players, limited data is available on age-appropriate categories. The purpose of this study is to determine the differences in specific anthropometric characteristics and jumping performance variables in under−19 female volleyball players in relation to playing position and performance level. The sample of subjects consisted of 354 players who prepared for the U19 Women’s Volleyball European Championship 2020 (17.4 ± 0.8 years, 1.81 ± 0.07 m, 67.5 ± 7.1 kg). Playing pos

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Jones, Graham. "The Role of Performance Profiling in Cognitive Behavioral Interventions in Sport." Sport Psychologist 7, no. 2 (1993): 160–72. http://dx.doi.org/10.1123/tsp.7.2.160.

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This paper reports a case study of a successful cognitive behavioral intervention using performance profiling. The subject, a top-10 female racket sport player, had a problem with her temperament on court, becoming angry and frustrated in pressure situations. Performance profiling was used for three major purposes: (a) to aid the sport psychologist in identifying an appropriate psychological intervention, (b) to maximize the performer’s self-motivation to partake in and adhere to the intervention, and (c) to monitor any changes during the intervention. A multimodal stress management approach w

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Duthie, Grant M. "A Framework for the Physical Development of Elite Rugby Union Players." International Journal of Sports Physiology and Performance 1, no. 1 (2006): 2–13. http://dx.doi.org/10.1123/ijspp.1.1.2.

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Increased professionalism in rugby has resulted in national unions developing high-performance models for elite player development, of which physical preparation is an important component, to ensure success in future years. This article presents a 5-step framework for the physical preparation of elite players in a development program. Competition movement patterns and the physical profiles of elite players are used as the basis of the framework and reinforce the repeated high-intensity nature of Rugby Union. Physical profiling highlights a player’s strengths and weaknesses in the areas of stre

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Mycko, Marcin P., and Sergio E. Baranzini. "microRNA and exosome profiling in multiple sclerosis." Multiple Sclerosis Journal 26, no. 5 (2020): 599–604. http://dx.doi.org/10.1177/1352458519879303.

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New DNA sequencing technologies have uncovered non-coding RNA (ncRNA) as a major player in regulating cellular processes and can no longer be dismissed as “junk” or “dark” RNA. Among the ncRNA, microRNA (miRNA) is arguably the most extensively characterized category and a number of studies have implicated them in regulating critical functions that can influence autoimmune demyelination. Of specific interest to multiple sclerosis (MS), miRNA have been implicated in both regulating immune responses and myelination, thus making them an attractive candidate for both pharmacological intervention an

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Javed, Saleha, and Kashif Zafar. "Player profiling and quality assessment of dynamic car racing tracks using entertainment quantifier technique." Computational Intelligence 34, no. 4 (2018): 1046–71. http://dx.doi.org/10.1111/coin.12161.

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Edwards, Joan E., Eun Joong Kim, David R. Davies, Radwa Hanafy, and Alison H. Kingston-Smith. "Ruminant Salivary Microbes: Passenger or Player in the Rumen?" Microorganisms 11, no. 10 (2023): 2390. http://dx.doi.org/10.3390/microorganisms11102390.

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Sampling of ruminant saliva has gained interest as a non-invasive proxy for exploring the structure of the rumen microbiome. However, the subsequent data analysis assumes that bacteria originating from the oral cavity are merely passengers in the rumen and play no active role. In this study, it was hypothesised that metabolically active oral bacteria present in the salivary microbiome play a role in the ruminal degradation of plant material. In vitro cultivation-based enumeration confirmed that the ruminant oral cavity harbours a significant number of anaerobic and cellulolytic bacteria that a

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Vig, Saurabh, Puneet Talwar, Kirandeep Kaur, Rohit Srivastava, Arvind K. Srivastava, and Malabika Datta. "Transcriptome profiling identifies p53 as a key player during calreticulin deficiency: Implications in lipid accumulation." Cell Cycle 14, no. 14 (2015): 2274–84. http://dx.doi.org/10.1080/15384101.2015.1046654.

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Meflah Alshahrani, Saeed, Atef Salem, Anis Zribi, Khaled Trabelsi, Achraf Ammar, and Hamdi Chtourou. "Anthropometric and Physical Profile Among the Different Age Groups of Tunisian Tennis Players." International Journal of Sport Studies for Health 6, no. 1 (2023): 5–12. http://dx.doi.org/10.61838/kman.intjssh.6.1.2.

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Background: The popularity of Tunisian tennis is on the rise, due to emerging players gaining global recognition, leading to growth and evolution in the sport. In order to optimize training and performance, coaches need valuable information on physical fitness and player profiling. Objectives: The study aimed to investigate the physical profile of Tunisian tennis players in different age groups ranging from 7 to 17 years. Methods: One hundred and one tennis players from the same team were assigned to six age groups (U9-U18); U9 (7.89 ± 0.32), U10 (8.88 ± 0.34), U11 (9.78 ± 0.43), U12 (10.81 ±

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Gerna, Davide, Erwann Arc, Max Holzknecht, et al. "AtFAHD1a: A New Player Influencing Seed Longevity and Dormancy in Arabidopsis?" International Journal of Molecular Sciences 22, no. 6 (2021): 2997. http://dx.doi.org/10.3390/ijms22062997.

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Fumarylacetoacetate hydrolase (FAH) proteins form a superfamily found in Archaea, Bacteria, and Eukaryota. However, few fumarylacetoacetate hydrolase domain (FAHD)-containing proteins have been studied in Metazoa and their role in plants remains elusive. Sequence alignments revealed high homology between two Arabidopsis thaliana FAHD-containing proteins and human FAHD1 (hFAHD1) implicated in mitochondrial dysfunction-associated senescence. Transcripts of the closest hFAHD1 orthologue in Arabidopsis (AtFAHD1a) peak during seed maturation drying, which influences seed longevity and dormancy. Her

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Anderson, Rozalyn. "METABOLIC INTEGRITY – A FACTOR IN AGING AND A PLAYER IN THE MECHANISMS OF CR." Innovation in Aging 3, Supplement_1 (2019): S67. http://dx.doi.org/10.1093/geroni/igz038.262.

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Abstract An emerging paradigm in aging research identifies metabolic dysfunction as a root cause in age-related disease vulnerability. Several diseases of aging, including diabetes, cancer, and neurodegeneration, have an established metabolic component. Our studies have focused on links between metabolic status and disease vulnerability. Caloric restriction (CR) delays aging and the onset of age-related disease in diverse species, including nonhuman primates. Molecular profiling identifies CR responsive elements in the transcriptome, proteome, and metabolome that are highly enriched for metabo

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Mitchell, Andy, Craig Holding, and Matt Greig. "The Influence of Injury History on Countermovement Jump Performance and Movement Strategy in Professional Soccer Players: Implications for Profiling and Rehabilitation Foci." Journal of Sport Rehabilitation 30, no. 5 (2021): 768–73. http://dx.doi.org/10.1123/jsr.2020-0243.

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Context: Professional soccer players who have sustained a lower limb injury are up to 3× more likely to suffer a reinjury, often of increased severity. Previous injury has been shown to induce compensatory strategies during neuromuscular screening tests, which might mask deficits and lead to misinterpretation of readiness to play based on task outcome measures. Objective: To investigate the influence of previous injury in professional soccer players on countermovement jump (CMJ) performance and movement strategy. Design: Cross-sectional. Setting: Professional soccer club competing in the Engli

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González-Aguilera, Cristina, Cristina Tous, Reyes Babiano, Jesús de la Cruz, Rosa Luna, and Andrés Aguilera. "Nab2 functions in the metabolism of RNA driven by polymerases II and III." Molecular Biology of the Cell 22, no. 15 (2011): 2729–40. http://dx.doi.org/10.1091/mbc.e11-01-0055.

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Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One important player in this interface is the poly(A)+-RNA–binding protein Nab2, which regulates the mRNA poly(A)+-tail length and export. Here we show that Nab2 has additional roles during mRNA transcription, tRNA metabolism, and ribosomal subunit export. Nab2 is associated with the entire open reading frame of actively transcribed RNA polymerase (RNAP) II and III genes. As a consequence, nab2 mutations confer translation defects that are detected by polysome profiling. Genome-wide a

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Mattioli, E., D. Di Marzo, I. Forte, et al. "44 A miRNA EXPRESSION PROFILING IDENTIFIES MIR-145 AS A KEY PLAYER IN HUMAN MALIGNANT PLEURAL MESOTHELIOMA." Cancer Treatment Reviews 36 (November 2010): S108. http://dx.doi.org/10.1016/s0305-7372(10)70070-0.

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Mathers, John F. "Professional Tennis on the ATP Tour: A Case Study of Mental Skills Support." Sport Psychologist 31, no. 2 (2017): 187–98. http://dx.doi.org/10.1123/tsp.2016-0012.

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Success on the Association of Tennis Professionals (ATP) World Tour requires a specific blend of perceptuomotor abilities, technical proficiency, tactical awareness and mental skills. This case study describes the competitive structure of professional tennis and outlines the program of mental skills delivered to a professional tennis player over a 3-year period. The program embraced five stages: (1) education; (2) assessment/profiling; (3) mental skill learning; (4) application of mental skills in context and (5) evaluation, and was associated with some positive outcomes. This case study provi

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Adeyemo, Victor Elijah, Anna Palczewska, Ben Jones, and Dan Weaving. "Identification of pattern mining algorithm for rugby league players positional groups separation based on movement patterns." PLOS ONE 19, no. 5 (2024): e0301608. http://dx.doi.org/10.1371/journal.pone.0301608.

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The application of pattern mining algorithms to extract movement patterns from sports big data can improve training specificity by facilitating a more granular evaluation of movement. Since movement patterns can only occur as consecutive, non-consecutive, or non-sequential, this study aimed to identify the best set of movement patterns for player movement profiling in professional rugby league and quantify the similarity among distinct movement patterns. Three pattern mining algorithms (l-length Closed Contiguous [LCCspm], Longest Common Subsequence [LCS] and AprioriClose) were used to extract

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Flett, M. Ryan. "Creating Probabilistic Idiographic Performance Profiles from Discrete Feelings: Combining the IZOF and IAPZ models." Sport Science Review 24, no. 5-6 (2015): 241–66. http://dx.doi.org/10.1515/ssr-2015-0018.

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Abstract The purpose of the study was to determine if probabilistic profiling could be used to develop probabilistic individual zones of optimal functioning (pIZOF) profiles comprised from discrete feelings aggregated into valence-function categories (Hanin, 2000a). Ten male college tennis players developed individualized profiles, and then assessed their personal profile’s items during changeovers of intrasquad matches. Support for the viability of using ordinal logistic regression (OLR; a foundation of the IAPZ method) to develop idiographic discrete performance-feeling profiles (common to t

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Seker, Fidan, Ahmet Cingoz, İlknur Sur-Erdem, et al. "Identification of SERPINE1 as a Regulator of Glioblastoma Cell Dispersal with Transcriptome Profiling." Cancers 11, no. 11 (2019): 1651. http://dx.doi.org/10.3390/cancers11111651.

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High mortality rates of glioblastoma (GBM) patients are partly attributed to the invasive behavior of tumor cells that exhibit extensive infiltration into adjacent brain tissue, leading to rapid, inevitable, and therapy-resistant recurrence. In this study, we analyzed transcriptome of motile (dispersive) and non-motile (core) GBM cells using an in vitro spheroid dispersal model and identified SERPINE1 as a modulator of GBM cell dispersal. Genetic or pharmacological inhibition of SERPINE1 reduced spheroid dispersal and cell adhesion by regulating cell-substrate adhesion. We examined TGFβ as a p

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Abdelnaby, Mai, Dahlia Badran, Maha Anani, et al. "Three key genes expression profiling in Egyptian rheumatoid arthritis patients." Egyptian journal of Immunology 29, no. 3 (2022): 19–28. http://dx.doi.org/10.55133/eji.290303.

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Rheumatoid arthritis (RA) is a multi-system autoimmune disease with synovial joints involvement. The triad of autoimmunity, genetics, and environment is the key player in RA pathogenesis. We intended to investigate gene expression of C-C Chemokine Ligand 2 (CCL2), protein tyrosine phosphatase non-receptor type 22 (PTPN22), and Cytotoxic T-lymphocyte associated protein 4 (CTLA-4) in RA patients versus controls, and its correlation with the activity of the disease. The relative expression of PTPN22, CTLA-4, and CCL2 in the peripheral blood of 59 RA patients and 50 controls was determined using R

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Czont, Attila, Tamas Freyer, Zsolt Bodor, Gyongyver Mara, Josif Sandor, and Ildiko Miklossy. "Position-based anthropometric characteristics and general physiological performance of national level, U18 ice hockey players." Sportis. Scientific Journal of School Sport, Physical Education and Psychomotricity 9, no. 1 (2023): 81–97. http://dx.doi.org/10.17979/sportis.2023.9.1.9200.

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Identifying talented players requires subjective, as well as objective assessments of playing ability and performance. The assessment of anthropometric characteristics, as well as general physiological performance can be used for player selection. The primary purpose of this study was to determine whether positional profiling is possible for national level ice hockey players by examining anthropometric characteristics and physiological performance. The study involved two ice-hockey teams, U18 and U23, in total of 49 athletes (32 forwards and 17 defensemen), members of the “Székelyföldi” Ice Ho

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Wang, Y., K. Afshari, M. Frisoli, et al. "140 Comparative scRNA-Seq profiling of four autoimmune skin diseases points to CXCL13 as a potential player in skin autoimmunity." Journal of Investigative Dermatology 143, no. 5 (2023): S24. http://dx.doi.org/10.1016/j.jid.2023.03.141.

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Peng, Lishun, Changying Zeng, Lei Shi, Hongmei Cai, and Fangsen Xu. "Transcriptional Profiling Reveals Adaptive Responses to Boron Defi ciency Stress in Arabidopsis." Zeitschrift für Naturforschung C 67, no. 9-10 (2012): 510–24. http://dx.doi.org/10.1515/znc-2012-9-1009.

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Boron (B) is a micronutrient for vascular plants, and B deficiency has been recognized as a limiting factor for crop production in many areas worldwide. To gain a better insight into the adaptability mechanism of plant responses to B starvation, an Arabidopsis whole genome Affymetrix GeneChip was used to evaluate global gene expression alterations in response to short- and long-term B deficiency stress. A large number of B deficiency-responsive genes were identified and grouped by their functions. Genes linked to jasmonic acid (JA) showed the most prominent response under B deficiency. The tra

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Kang, Hong Soon, Yong-Sik Kim, Gary ZeRuth та ін. "Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic β-Cell Development and Insulin Gene Expression". Molecular and Cellular Biology 29, № 24 (2009): 6366–79. http://dx.doi.org/10.1128/mcb.01259-09.

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ABSTRACT In this study, we report that the Krüppel-like zinc finger transcription factor Gli-similar 3 (Glis3) is induced during the secondary transition of pancreatic development, a stage of cell lineage specification and extensive patterning, and that Glis3zf / zf mutant mice develop neonatal diabetes, evidenced by hyperglycemia and hypoinsulinemia. The Glis3zf / zf mutant mouse pancreas shows a dramatic loss of β and δ cells, contrasting a smaller relative loss of α, PP, and ε cells. In addition, Glis3zf / zf mutant mice develop ductal cysts, while no significant changes were observed in a

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Fragliasso, Valentina, Annalisa Tameni, Akanksha Verma, et al. "The DNA Helicase Hells Is a New Unconventional Player in ALK- Anaplastic Large Cell Lymphoma Biology." Blood 134, Supplement_1 (2019): 1477. http://dx.doi.org/10.1182/blood-2019-122701.

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Anaplastic Large Cell Lymphoma (ALCL) is an aggressive subtype of T-cell lymphoma. ALCLs are stratified based on the presence of anaplastic lymphoma kinase (ALK) translocations. ALK negative (ALK-ALCLs) are heterogeneous subtypes characterized by higher aggressiveness and poorer outcome than ALK+ALCL. The molecular and genetic asset of ALK-ALCLs has recently begun to emerge (i.e. JAK/STAT3 activating mutations, DUSP22, TP63, TP53 and IRF4 rearrangements), but an exhaustive picture of the molecular drivers leading to ALK-ALCLs transformation, progression, and immune evasion is still lacking. Lo

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Verdile, Veronica, Francesca Svetoni, Piergiorgio La Rosa, et al. "EWS splicing regulation contributes to balancing Foxp1 isoforms required for neuronal differentiation." Nucleic Acids Research 50, no. 6 (2022): 3362–78. http://dx.doi.org/10.1093/nar/gkac154.

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Abstract Alternative splicing is a key regulatory process underlying the amplification of genomic information and the expansion of proteomic diversity, particularly in brain. Here, we identify the Ewing sarcoma protein (EWS) as a new player of alternative splicing regulation during neuronal differentiation. Knockdown of EWS in neuronal progenitor cells leads to premature differentiation. Transcriptome profiling of EWS-depleted cells revealed global changes in splicing regulation. Bioinformatic analyses and biochemical experiments demonstrated that EWS regulates alternative exons in a position-

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Wu, Zeming, Yue Shi, Mingming Lu, et al. "METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA." Nucleic Acids Research 48, no. 19 (2020): 11083–96. http://dx.doi.org/10.1093/nar/gkaa816.

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Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known epitranscriptional regulatory mechanism affecting central biological processes, but its function in human cellular senescence remains uninvestigated. Here, we found that levels of both m6A RNA methylation and the methyltransferase METTL3 were reduced in prematurely senescent human mesenchymal stem cell (hMSC) models of progeroid syndromes. Transcriptional profiling of m6A modifications further identified MIS12, for which m6A modifications were reduced in both prematurely senescent hMSCs and METTL3-deficient hMSCs. Knoc

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Karton, Clara, Michael D. Gilchrist, and Thomas Blaine Hoshizaki. "Profiling position specific head trauma in professional American football based on impact magnitude and frequency." Neurology 91, no. 23 Supplement 1 (2018): S1.1—S1. http://dx.doi.org/10.1212/wnl.0000000000006599.

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In American football repetitive brain trauma is associated with high risk of neurologic disorders. Head contact is integral to the game, resulting in high frequency of head contacts during a game/season. Low energy impacts that do not manifest signs recognized as injury still present metabolic and/or physiologic changes within the brain. The purpose was to estimate player position specific brain trauma profiles based on strain magnitude and impact frequency. Head impacts from 32 game films of professional football were documented and categorized based on event type, head location, and velocity

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Fraccarollo, Daniela, Svenja Thomas, Claus-Jürgen Scholz, Denise Hilfiker-Kleiner, Paolo Galuppo, and Johann Bauersachs. "Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing." Hypertension 73, no. 1 (2019): 102–11. http://dx.doi.org/10.1161/hypertensionaha.118.12162.

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Myocardial infarction (MI) is a major cause of death worldwide. Here, we identify the macrophage MR (mineralocorticoid receptor) as a crucial pathogenic player in cardiac wound repair after MI. Seven days after left coronary artery ligation, mice with myeloid cell–restricted MR deficiency compared with WT (wild type) controls displayed improved cardiac function and remodeling associated with enhanced infarct neovascularization and scar maturation. Gene expression profiling of heart-resident and infarct macrophages revealed that MR deletion drives macrophage differentiation in the ischemic micr

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Gurda, Grzegorz T., Jackie Y. Wang, LiLi Guo, Stephen A. Ernst, and John A. Williams. "Profiling CCK-mediated pancreatic growth: the dynamic genetic program and the role of STATs as potential regulators." Physiological Genomics 44, no. 1 (2012): 14–24. http://dx.doi.org/10.1152/physiolgenomics.00255.2010.

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Feeding mice with protease inhibitor (PI) leads to increased endogenous cholecystokinin (CCK) release and results in pancreatic growth. This adaptive response requires calcineurin (CN)-NFAT and AKT-mTOR pathways, but the genes involved, the dynamics of their expression, and other regulatory pathways remain unknown. Here, we examined the early (1–8 h) transcriptional program that underlies pancreatic growth. We found 314 upregulated and 219 downregulated genes with diverse temporal and functional profiles. Several new identifications include the following: stress response genes Gdf15 and Txnip,

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Wang, Guangming, Fangce Wang, Jie Ren, et al. "SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells." Cellular Physiology and Biochemistry 48, no. 2 (2018): 657–69. http://dx.doi.org/10.1159/000491893.

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Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR). Sirt1, a prominent anti-aging player, plays pivotal roles in the DDR. However, few studies have examined alternative splicing with DNA damage in neural stem cells (NSCs) and, in essence, nothing is known about whether SIRT1 regulates alternative splicing. Hence, we investigated the potential involvement of Sirt1-mediated alternative splicing in the NSC DDR. Methods: Ge

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Gandillet, Arnaud, Alicia G. Serrano, Stella Pearson, Michael Lie-A-Ling, Georges Lacaud, and Valerie Kouskoff. "Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification." Blood 114, no. 23 (2009): 4813–22. http://dx.doi.org/10.1182/blood-2009-06-226290.

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Abstract The molecular mechanisms that regulate the balance between proliferation and differentiation of precursors at the onset of hematopoiesis specification are poorly understood. By using a global gene expression profiling approach during the course of embryonic stem cell differentiation, we identified Sox7 as a potential candidate gene involved in the regulation of blood lineage formation from the mesoderm germ layer. In the present study, we show that Sox7 is transiently expressed in mesodermal precursors as they undergo specification to the hematopoietic program. Sox7 knockdown in vitro

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Wang, Samuel S. Y., Wee Joo Chng, Haiyan Liu, and Sanjay de Mel. "Tumor-Associated Macrophages and Related Myelomonocytic Cells in the Tumor Microenvironment of Multiple Myeloma." Cancers 14, no. 22 (2022): 5654. http://dx.doi.org/10.3390/cancers14225654.

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Multiple myeloma (MM) is the second-most common hematologic malignancy and remains incurable despite potent plasma cell directed therapeutics. The tumor microenvironment (TME) is a key player in the pathogenesis and progression of MM and is an active focus of research with a view to targeting immune dysregulation. Tumor-associated macrophages (TAM), myeloid derived suppressor cells (MDSC), and dendritic cells (DC) are known to drive progression and treatment resistance in many cancers. They have also been shown to promote MM progression and immune suppression in vitro, and there is growing evi

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Kadioglu, Onat, Mohamed Saeed, Nuha Mahmoud, et al. "Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion." Archives of Toxicology 95, no. 3 (2021): 959–74. http://dx.doi.org/10.1007/s00204-021-02979-4.

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AbstractTP53 (p53) is a pivotal player in tumor suppression with fifty percent of all invasive tumors displaying mutations in the TP53 gene. In the present study, we characterized colon cancer cells (HCT116 p53 −/−) with TP53 deletion, a sub-line derived from HCT116-p53 +/+ cells. RNA sequencing and network analyses were performed to identify novel drug resistance mechanisms. Chromosomal aberrations were identified by multicolor fluorescence in situ hybridization (mFISH) and array comparative genomic hybridization (aCGH). Numerous genes were overexpressed in HCT116 p53 −/− cells: RND3/RhoE (23

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Krauß, Lukas, Bettina C. Urban, Sieglinde Hastreiter, et al. "HDAC2 Facilitates Pancreatic Cancer Metastasis." Cancer Research 82, no. 4 (2021): 695–707. http://dx.doi.org/10.1158/0008-5472.can-20-3209.

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Abstract The mortality of patients with pancreatic ductal adenocarcinoma (PDAC) is strongly associated with metastasis, a multistep process that is incompletely understood in this disease. Although genetic drivers of PDAC metastasis have not been defined, transcriptional and epigenetic rewiring can contribute to the metastatic process. The epigenetic eraser histone deacetylase 2 (HDAC2) has been connected to less differentiated PDAC, but the function of HDAC2 in PDAC has not been comprehensively evaluated. Using genetically defined models, we show that HDAC2 is a cellular fitness factor that c

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Larochelle, Marc, Simon Drouin, François Robert, and Bernard Turcotte. "Oxidative Stress-Activated Zinc Cluster Protein Stb5 Has Dual Activator/Repressor Functions Required for Pentose Phosphate Pathway Regulation and NADPH Production." Molecular and Cellular Biology 26, no. 17 (2006): 6690–701. http://dx.doi.org/10.1128/mcb.02450-05.

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ABSTRACT In Saccharomyces cerevisiae, zinc cluster protein Pdr1 can form homodimers as well as heterodimers with Pdr3 and Stb5, suggesting that different combinations of these proteins may regulate the expression of different genes. To gain insight into the interplay among these regulators, we performed genome-wide location analysis (chromatin immunoprecipitation with hybridization to DNA microarrays) and gene expression profiling. Unexpectedly, we observed that Stb5 shares only a few target genes with Pdr1 or Pdr3 in rich medium. Interestingly, upon oxidative stress, Stb5 binds and regulates

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Dunand-Sauthier, Isabelle, Marie-Laure Santiago-Raber, Leonardo Capponi, et al. "Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function." Blood 117, no. 17 (2011): 4490–500. http://dx.doi.org/10.1182/blood-2010-09-308064.

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Abstract MicroRNAs (miRNAs) are small, noncoding RNAs that regulate target mRNAs by binding to their 3′ untranslated regions. There is growing evidence that microRNA-155 (miR155) modulates gene expression in various cell types of the immune system and is a prominent player in the regulation of innate and adaptive immune responses. To define the role of miR155 in dendritic cells (DCs) we performed a detailed analysis of its expression and function in human and mouse DCs. A strong increase in miR155 expression was found to be a general and evolutionarily conserved feature associated with the act

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Monni, Richard, Lamya Haddaoui, Alexandra Naba, et al. "Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia." Blood 111, no. 6 (2008): 3163–72. http://dx.doi.org/10.1182/blood-2007-09-110510.

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Abstract The model of erythroleukemia caused by Spi-1/PU.1 transgenesis in mice is a multistage disease. A preleukemic step is characterized by an acute proliferation of proerythroblasts due to the arrest of differentiation provoked by Spi-1/PU.1. Later on, a blastic crisis occurs associated with somatic oncogenic mutations in the stem cell factor (SCF) receptor kit. To gain insights into the mechanisms of the leukemic progression, we performed proteomic profiling analyses of proerythroblasts isolated at the 2 stages of the disease. Our results indicate that the level of ezrin, a membrane cyto

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Chauhan, Anshika, Geeta S. Boora, Sahana Ghosh, et al. "Abstract 2311: Extensive molecular heterogeneity in circulating tumor cells: A key player in oral squamous cell carcinoma prognosis." Cancer Research 83, no. 7_Supplement (2023): 2311. http://dx.doi.org/10.1158/1538-7445.am2023-2311.

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Abstract Background: Oral Squamous cell carcinoma (OSCC) often results in unfavorable outcomes due to locoregional relapse. While circulating tumor cells (CTCs) may be attributed to these locoregional metastases, detecting CTCs and their molecular profiling remains challenging. Here we report a novel strategy for isolating CTCs in OSCC. Secondly, we characterized the CTCs to prognosticate the disease outcome using their transcriptomic signature. Methods: Keeping in view the inherent disadvantages of currently available CTC-isolation techniques, like the use of single marker or size-based isola

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Duś-Szachniewicz, Kamila, Grzegorz Rymkiewicz, Anil Kumar Agrawal, Paweł Kołodziej, and Jacek R. Wiśniewski. "Large-Scale Proteomic Analysis of Follicular Lymphoma Reveals Extensive Remodeling of Cell Adhesion Pathway and Identifies Hub Proteins Related to the Lymphomagenesis." Cancers 13, no. 4 (2021): 630. http://dx.doi.org/10.3390/cancers13040630.

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Follicular lymphoma (FL) represents the major subtype of indolent B-cell non-Hodgkin lymphomas (B-NHLs) and results from the malignant transformation of mature B-cells in lymphoid organs. Although gene expression and genomic studies have identified multiple disease driving gene aberrations, only a few proteomic studies focused on the protein level. The present work aimed to examine the proteomic profiles of follicular lymphoma vs. normal B-cells obtained by fine-needle aspiration biopsy (FNAB) to gain deep insight into the most perturbed pathway of FL. The cells of interest were purified by ma

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Gambella, Alessandro, Antonella Barreca, Simona Osella-Abate, et al. "Caveolin-1 in Kidney Chronic Antibody-Mediated Rejection: An Integrated Immunohistochemical and Transcriptomic Analysis Based on the Banff Human Organ Transplant (B-HOT) Gene Panel." Biomedicines 9, no. 10 (2021): 1318. http://dx.doi.org/10.3390/biomedicines9101318.

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Caveolin-1 overexpression has previously been reported as a marker of endothelial injury in kidney chronic antibody-mediated rejection (c-ABMR), but conclusive evidence supporting its use for daily diagnostic practice is missing. This study aims to evaluate if Caveolin-1 can be considered an immunohistochemical surrogate marker of c-ABMR. Caveolin-1 expression was analyzed in a selected series of 22 c-ABMR samples and 11 controls. Caveolin-1 immunohistochemistry proved positive in peritubular and glomerular capillaries of c-ABMR specimens, irrespective of C4d status whereas all controls were n

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Basu, Somsuvro, Joanne C. Leonard, Nishal Desai, et al. "Divergence of Erv1-Associated Mitochondrial Import and Export Pathways in Trypanosomes and Anaerobic Protists." Eukaryotic Cell 12, no. 2 (2012): 343–55. http://dx.doi.org/10.1128/ec.00304-12.

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ABSTRACT In yeast ( Saccharomyces cerevisiae ) and animals, the sulfhydryl oxidase Erv1 functions with Mia40 in the import and oxidative folding of numerous cysteine-rich proteins in the mitochondrial intermembrane space (IMS). Erv1 is also required for Fe-S cluster assembly in the cytosol, which uses at least one mitochondrially derived precursor. Here, we characterize an essential Erv1 orthologue from the protist Trypanosoma brucei (TbERV1), which naturally lacks a Mia40 homolog. We report kinetic parameters for physiologically relevant oxidants cytochrome c and O 2 , unexpectedly find O 2 a

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Abd El-Baky, Nawal, Amro A. Amara, and Elrashdy M. Redwan. "HLA-I and HLA-II Peptidomes of SARS-CoV-2: A Review." Vaccines 11, no. 3 (2023): 548. http://dx.doi.org/10.3390/vaccines11030548.

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The adaptive (T-cell-mediated) immune response is a key player in determining the clinical outcome, in addition to neutralizing antibodies, after SARS-CoV-2 infection, as well as supporting the efficacy of vaccines. T cells recognize viral-derived peptides bound to major histocompatibility complexes (MHCs) so that they initiate cell-mediated immunity against SARS-CoV-2 infection or can support developing a high-affinity antibody response. SARS-CoV-2-derived peptides bound to MHCs are characterized via bioinformatics or mass spectrometry on the whole proteome scale, named immunopeptidomics. The

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