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Dissertations / Theses on the topic 'PLMIC'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 February 2022

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1

Chai, Shan, and shan chai@optusnet com au. "Performance Evaluation of Perceptually Lossless Medical Image Coder." RMIT University. Electrical and Computer Engineering, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080205.120648.

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Medical imaging technologies offer the benefits of faster and accurate diagnosis. When the medical imaging combined with the digitization, they offer the advantage of permanent storage and fast transmission to any geographical location. However, there is a need for efficient compression algorithms that alleviate the taxing burden of both large storage space and transmission bandwidth requirements. The Perceptually Lossless Medical Image Coder is a new image compression technique. It provides a solution to challenge of delivering clinically critical information in the shortest time possible. It
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2

Sonnenschein, Jiří. "Návrh řídícího systému pro mobilní cirkulační systém pro transport plic." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220836.

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In the first part of this master’s thesis an overview about lungs (anatomy, physiology and respiratory mechanics) is given. Next sections are focused on description of the mechanical lung simulator and the mobile circulatory module. The use, construction, function, observed parameters and control scheme of the mobile circulatory module is described. Control unit which is divided into separate modules is introduced including description of power supply and communication. In following chapters a description of DCNM (Direct Control and Notification Module) is given.
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Paštěka, Richard. "Integrace a testování real-time řídicí jednotky pro simulaci plic." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2016. http://www.nusl.cz/ntk/nusl-242052.

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Aktivní mechanický plicní simulátor (iLung) nabízí možnost simulace lidského dýchání. Cílem této práce je implementovat a otestovat řídící a akviziční systém cRIO pracující v reálném čase, jako řídící jednotku simulátoru. Výsledné propojení obou zařízení je zdokumentováno ve formě tabulek a původních osazovacích výkresů, které jsou doplněny o popis funkce každého pinu. Významného zlepšení bylo dosaženo laděním motoru a modifikací proporcionálně-integračního regulátoru v řídícím programu. Tyto modifikace mají za následek významné snížení oscilací v okolí nuly. Pro zvýšení využitelnosti a přístu
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Trávníčková, Hana. "Implementace přenosového protokolu pro přenos dat mobilní cirkulační jednotky pro převoz plic." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220838.

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The aim of this thesis is a data transfer protocol implementation for a mobile control unit for transporting lungs. Apart from this thesis the data transfer protocol is used in AlveoPic project. The introductory part is focused on an anatomical and physiological background of a human respiratory system. Consequently it describes the i-Lung module and the mobile circulation module (MCM). It deals with the healthcare informatics interoperability standards with an emphasis to the ISO/IEEE 11073 standard. The subsequent part is represented by MCM’s simulator realization and design of a monitoring
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Heir, Renu. "PLIC-1 plays a dual role in protein aggregate transport and proteasomal shuttling." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101137.

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Defects in protein folding and the proteasomal pathway have been linked with numerous neurodegenerative diseases. PLIC-1 is a Ubiquitin- like (UBL) protein that binds the ubiquitin- interacting motif (UIM) of the proteasomal subunit S5a, and has been proposed to act as a proteasomal shuttle. Here, we show the UBL of PLIC-1 also binds the UIM-containing EPS15, an endocytic protein, and they function together in the transport of aggregates to the perinuclear aggresome.<br>We also show PLIC-1 changes localization upon expression of an endoplasmic reticulum-associated degradation (ERAD) substrate,
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Therien, James Patrick Daniel. "The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35643.

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The pentameric ligand gated ion channel super family plays a central role in fast synaptic communication between neurons and at the neuromuscular junction. Extensive studies on the prototypic pLGIC, the Torpedo nicotinic acetylcholine receptor (nAChR) have revealed an exquisite lipid sensitivity, with the nAChR adopting a novel uncoupled conformation in membranes lacking activating anionic and neutral lipids. The lipid-exposed transmembrane alpha-helix, M4, in each homologous subunit likely acts as a lipid sensor. One model proposes that activating lipids promote M4 “binding” to the adjacent a
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7

Cerdan, Adrien. "Exploration de la transmission synaptique et de la régulation des récepteurs ionotropes par simulations de dynamique moléculaire et électrophysiologie numérique." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAF006/document.

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Au niveau de la synapse, la liaison des neurotransmetteurs aux récepteurs membranaires induit l’ouverture de canaux ioniques. Le Récepteur de la Glycine (RGly) est un récepteur ionotrope impliqué dans des troubles neuronaux tels que l’addiction, la douleur chronique, ou l’hyperekplexie ; pour cette raison il est important de développer des nouveaux traitements ciblant ce récepteur. Nous avons utilisé des simulations de Dynamiques Moléculaire (DM) et d’électrophysiologie numérique afin d’évaluer la fonction des structures du RGly disponibles et montré qu’aucune d’entre elles ne satisfait les pr
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8

Šimonková, Karolína. "Porovnání účinnosti vybraných metod léčení rakoviny prostaty a prsu pomocí analýzy přežití." Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-359539.

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This diploma thesis deals with various ways of treatment of selected oncological diseases and the effectiveness of treatment methods and evaluation of the influence of various factors influencing the survival of patients. The activity of individual healing processes is evaluated by survival analysis. The subjects of the study are patients with breast, lung and prostate cancer. The survival analysis considers the sex of the patient, the age and stage of his illness, and other factors to avoid distorted results. The aim of the work is to find out the effects of selected therapeutic procedures on
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Votoupal, Pavel. "Segmentace dýchacích cest v CT datech." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2015. http://www.nusl.cz/ntk/nusl-221386.

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This thesis deals with the segmentation of lung parenchyma and extraction of airways tree from three dimensional CT scans. The external mask of the lungs is created and subsequently used to ease the process of airway segmentation. In this work, some published methods for airways segmentation are described with focus on one, which is described more in detail and also implemented in MATLAB. The proposed approach is based on morphological grayscale reconstruction. Method is tested on the real patient CT scans and finally, the results are discussed.
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Černý, Petr. "Ekonomické hodnocení ozdravného protiradonového opatření u rodinných domů." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-86036.

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The aim of the thesis is to valuate economic effectivity of radon mitigation countermeasures co-financed by the state applied in family houses which display high radon level. Feasibility of the mitigation is analysed without concering financing source. Furthermore, the project is valuated from the point of view of the house owner and from the state's point of view. Presence of residental radon is increasing lung cancer probability, radon has notable healt effects. Costs and benefit of the hypothetic project are vauated in CBA analysis. The author finds the project unfeasible. CBA is discussed
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Lízal, František. "Experimentální výzkum transportu a depozice aerosolů v dýchacím traktu člověka." Doctoral thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-234006.

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Human health is significantly influenced by inhaled aerosols. Insight to the aerosol transport and deposition mechanisms is a prerequisite for both, toxicological protection against harmful particles and efficient application of inhaled therapeutic aerosols. The purpose of this doctoral thesis was to gain new knowledge of this topic on the basis of in vitro measurements. Phase-Doppler Anemometry was chosen for aerosol transport measurement, for it allows simultaneous measurement of particle size and velocity. Results were processed by means of statistical methods and frequency analysis. Deposi
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Lippay, Josef. "Využití fluorescenčních technik ve studiu depozice aerosolů." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2013. http://www.nusl.cz/ntk/nusl-216961.

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Several experiments were designed for utilization of fluorescence spectroscopy as a method of aerosol particle detection in a model of lungs. One of the experiments was to arranged use luminescent properties of DEHS (bis(2-ethylhexyl)decandioate) for calculating aerosol deposition. The outcome of this experiment was confirmation of clusters existence, which causes luminescence of DEHS. But the luminescence is not enough dependent on concentration and as such is not suitable for calculation of aerosol deposition. As the next experiment DEHS-fluorescein particles were generated by condensation m
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Kupková, Karolína. "Model dynamických kontrastních CT dat pro hodnocení lícovacích algoritmů." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2013. http://www.nusl.cz/ntk/nusl-220034.

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This work is focused on the description of the dynamic contrast-enhanced CT examination and its contribution in the pneumooncology. It includes a program for creating a two-dimensional model of the scan from the thorax and for the perfuse examination simulation using the time-density curve. Real CT data are simulated more authentic using rigid geometric transformations and noise. The model will be used for the validation of registration algorithms that is used to suppress the spatial deformation generated by patient motions during the long time examination.
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14

Laurent, Benoist. "Étude de l'anesthésie générale à l'échelle atomique par modélisation d'un homologue bactérien du récepteur nicotinique humain." Phd thesis, Université Paris-Diderot - Paris VII, 2014. http://tel.archives-ouvertes.fr/tel-01053431.

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La découverte des anesthésiques représente un progrès majeur de la médecine, rendu possible par l'observation empirique de leurs effets. Des expériences ont révélées les neurorécepteurs comme cibles possibles des anesthésiques, des canaux localisés sur la membrane des cellules cibles aux terminaisons nerveuses. Le récepteur GLIC, un homologue bactérien du récepteur nicotinique humain, a été co-cristallisé en 2011 avec des anesthésiques généraux liés à lui. Dans cette thèse, j'utilise les simulations de dynamique moléculaire pour caractériser les interactions entre des
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Pauk, Norbert. "Rizikové faktory karcinomu plic." Doctoral thesis, 2008. http://www.nusl.cz/ntk/nusl-292675.

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The objective of the fi rst part of the thesis was to estimate risk and protective factors on lung cancer risk in females, especially to study the differences in the impact of diet and physical exercise on lung cancer risk in female nonsmokers vs. smokers, and reveal interactions, if any. In a hospital based case-control study, data collected by in-person interviews from 569 female lung cancer cases and 2120 controls were analyzed using unconditional logistic regression stratifying by appropriate factors. To investigate the role of tobacco and some other known or suspected factors responsible
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Talašová, Marcela. "Onemocnění plic způsobená prachem azbestu." Master's thesis, 2006. http://www.nusl.cz/ntk/nusl-268116.

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Baráková, Táňa. "Funkční zobrazovací metody karcinomu plic." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-390033.

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Topic: Functional imaging methods of lung cancer MUDr. Táňa Baráková, Klinika zobrazovacích metod FN Plzeň Introduction: The aim of my work was to assess the use of direct quantification of dual-energy CT (DE-CT) radiation in the diagnosis and monitoring of non-small cell lung cancer (NSCLC) therapy. The work consists of three studies that were performed on Department of imaging methods. The main objectives were to assess the contribution of iodine quantification from DE-CT examinations, to verify the setting and to incorporate the DE-CT examination of the chest into a routine investigation. F
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Herbrík, Andrej. "Kolonizace lidských plic nepatogenními streptomycetami." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-411448.

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Streptomycetes, primary soil saprophytic microorganisms are at the center of interest in many research groups, mainly because of their ability to produce a wide range of biologically active substances useful in medicine, biotechnology and agriculture. The marginal, and little explored areas are the interactions that streptomycetes create with humans. Recent metagenomic studies have shown that streptomycetes colonize the skin, the respiratory and possibly the urogenital tract of humans. In addition to apparent pathogens such as S. somaliensis and S. sudanensis, the clinical impact of these stre
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Čermáková, Anna. "Rizikové faktory karcinomu plic. Plicní karcinom u žen." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-273143.

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Theme of her thesis dealing with lung cancer women I have chosen not only because it belongs to the Czech Republic countries with high incidence and mortality for lung cancer, but also personal interest in this issue. Lung cancer is by far the most common malignant us cancer in men. For women, the incidence of this tumor is about four times lower than in men, but worrying is the fact that the curve for women incidence has increased steadily. Although a direct link has been demonstrated a number of risk factors, especially smoking, another question arises about the influence of other substances
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Čapková, Linda. "Histopatologická a molekulární diagnostika nádorů plic a pleury." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-336180.

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The aim of the presented thesis is to introduce modern molecular methods that may contribute to deepening our knowledge of pulmonary carcinogenesis. Furthermore, we would like to point out the significance of immunohistochemistry in differential diagnostics of the most common primary pulmonary and pleural neoplasms. Lung carcinoma of all histological subtypes is a result of stepwise accumulation of genetic and epigenetic changes, including allelic losses (LOH), chromosomal instability and imbalance, oncogene and tumor suppressor gene mutations, epigenetic silencing by promotor hypermethylation
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Obertová, Nikola. "Inhalační podání léčiv v terapii obstrukčních chorob plic." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-356262.

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Use of inhaled drugs in obstructive pulmonary diseases Author: Nikola Obertová 1 Tutor: Josef Malý 1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and objectives: Chronic respiratory diseases are emerging health problem. The administration of the medication is mostly performed by the process of inhalation. Therefore, a proper inhalation technique plays a crucial role in symptom reduction and achievement of adequate control over the disease. The aim of the thesis was partly to assess the level of inhalation technique in elde
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Roušalová, Ilona. "Exprese a funkce serpinu B9 v buňkách karcinomu plic." Doctoral thesis, 2012. http://www.nusl.cz/ntk/nusl-305929.

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Background: Granzyme B (GrB) is a key proapoptotic secretory protease of CTLs and NK cells. Its specific proapoptotic effects in cancer cells can be blocked by increased expression of serpinB9. SerpinB9 gene expression can be transcriptionally upregulated by some interleukins and by the oestrogen activated oestrogen receptor-α (ERα) in cells which express ERα protein. The aims of my thesis were to evaluate the expression of SB9 and to examine its inhibitory activity against exogenous active GrB in non-small cell lung carcinoma (NSCLC) cell lines and tissues. To analyse the expression status of
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Šafránek, Jarmil. "Využití nádorových markerů v pooperační prognóze nemalobuněčného karcinomu plic." Doctoral thesis, 2009. http://www.nusl.cz/ntk/nusl-273450.

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USE OF TUMOR MARKERS IN POSTOPERATIVE PROGNOSIS OF NON-SMALL- CELL LUNG CANCER Introduction: The most frequently used prognostic parameters in clinical practice of NSCLC are disease stadium and affection of hilar or mediastinal lymph nodes. These phactors are not sufficient and therefore new prognostic parameters - tumor markers - are being searched for. Tumor markers regarding NSCLC have mainly been used so far to monitore effects of medical treatment or detection of carcinoma recurrency. The study concentrates on assessment of tumor markers significance for NSCLC. Methods: The total group in
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Mukenšnabl, Petr. "Diferenciální diagnostika vybraných vzácnějších benigních nádorů plic a pleury." Doctoral thesis, 2010. http://www.nusl.cz/ntk/nusl-278231.

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Selected rare benign tumors of the lung and pleura were studied with special reference to immunohistochemical findings and their differential diagnosis. The major objective is to better characterize unusual rare pulmonary tumors, which are unknown to most pathologists not specialized in pulmonary pathology. Moreover the clinicians, in particular, radiologists, pneumologists, surgeons, and oncologists are not familiar with these rare tumors as well. Therefore, these rare entities may cause a considerable problems in differential diagnostics and therapeutic management of the patients. The study
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Myšíková, Dagmar. "Studium protinádorové imunitní reakce u pacientů s karcinomem plic." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-389838.

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Lung cancer is the leading cause of cancer mortality worldwide. Understanding biological processes of specific antitumor immune response remains of an eminent interest and represents necessity for designing successful antitumor immunotherapeutic strategies. The theoretical part of the thesis describes components of the immune system that are involved in antitumor response and discusses their role in the hitherto known and used lung cancer immunotherapy. In the practical part of the thesis, two studies studying different aspects of anticancer immune response are described. Both studies were con
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Kynčl, Martin. "Management a zobrazení vrozených vývojových vad plic u dětí." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-353436.

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Background Bronchopulmonary malformations (BPMs) consists of a broad spectrum of developmental abnormalities, ranging from abnormal lung with normal vasculature to abnormal vasculature with normal lungs and lesions with both parenchymal and vascular abnormalities. Terminology remains a problem, the use of descriptive approach is strongly supported in practice. The aim of our study was to assess the accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) in classifying the different types of BPMs and to correlate this imaging with pathologic finding. Materials and methods We i
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Kobosilová, Linda. "Exprese markerů imunogenní buněčné smrti na buňkách karcinomu plic." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-332417.

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Immunogenic cell death (ICD) is characterized by presence of specific molecules including surface exposed calreticulin (CRT) and the heat shock proteins HSP70 and HSP90. Release of ATP and high- mobility group box protein 1 (HMGB1) belongs to other typical characteristics. For induction of ICD in lung cancer cells high-hydrostatic pressure (HHP) was used. Treatment by HHP induces expression of immunogenic markers CRT, HSP70 and HSP90 on the cell surface. HHP also induces secretion of ATP to the extracellular milieu. Dendritic cells (DC) pulsed with HHP-treated tumor cells showed fenotypic matu
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Chiu, Yi-Ling, and 邱伊伶. "Numerical Study of Wave Breaking Using PLIC-VOF Method." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/43135180905259776729.

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碩士<br>國立成功大學<br>水利及海洋工程學系碩博士班<br>95<br>The purpose of the present study is to develop a two-dimensional numerical model based on RANS (Reynolds Averaged Navier-Stokes) equations combined with a second-order k − ε turbulence closure model. The wave breaking process such as water waves travel over a sloping bottom is investigated. To track free surface movements, the VOF (Volume of Fluid) coupled with PLIC (Piecewise Linear Interface Construction) method is employed. To ensure the accuracy of the numerical model, numerical results were compared with Ting and Kirby’s (1994) experiment data for th
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Douděrová, Aneta. "Radiosensibilizace linie buněk nemalobuněčného karcinomu plic pomocí inhibitoru autofagie Lys05." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-380477.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Aneta Douděrová Supervisor: RNDr. Miloslav Macháček, PhD. Consultants: pplk. doc. PharmDr. Aleš Tichý, PhD. Title of diploma thesis: Radiosensitization of non-small cell lung cancer cell line using autophagy inhibitor Lys05 Nowadays, tumor diseases belong to the world's main causes of death. Research in the area of tumor treatment deals with the development of new methods that improve the health of patients. The aim of my diploma thesis was to find out if the usage of autophagy inhibitors
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Lischke, Robert. "Imunosupresivní terapie u pacientů po transplantaci plic a její komplikace." Doctoral thesis, 2006. http://www.nusl.cz/ntk/nusl-268844.

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Induction therapy in lung transplantation: initial single-center experience comparing daclizumab and anti-thymocyte globulin BACKGROUND: Acute and chronic rejection remain unresolved problems after lung transplantation, despite heavy multidrug immunosuppression. In turn, the strong immunosuppression has been responsible for mortality and pervasive morbidity. Because acute rejection is associated with inferior outcomes in lung transplantation, we have routinely employed anti-thymocyte globulin (ATG), or daclizumab as adjuncts to reduce rejection. Daclizumab is a human monoclonal antibody that b
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PLECEROVÁ, Jana. "Role sester v pooperační péči u pacientů s karcinomem plic." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-398937.

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The objectives of the work The objective of this work has been set as the mapping of degree of patient's contentment/ rate of patient's satisfaction in view of the nurse's approach within the scope of the post-thoracic operation care and the evaluation/ assessment whether the needs of the aforementioned patients have been satisfied. Another objective of the research enquiry has been set as finding out the level of the nurse's awareness regarding the ways and possibilities of the subsequent care. Methodology For the purpose of the research enquiry the form of qualitative research has been ch
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Benediktová, Květa. "Fyzioterapie jako součást multidisciplinární péče u pacientů po transplantaci plic." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-330278.

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Title: Physiotherapy as part of multidisciplinary care for patients following a lung transplant operation Objective: To evaluate the mobility of patients in the first days after lung transplantation. To compare the quality of life according to Karnofsky index and Jones dyspnea index. To relate spirometric values FVC and FEV1 of patients in the period prior to lung transplantation with the values in the first year after lung transplantation. Check the link between the development of quality of life and development of spirometric values. Methods: It is a pilot study, which was attended by 18 pro
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Saláková, Kamila. "Vliv kondice pacientů před transplantací plic na délku hospitalizace po transplantaci." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-435686.

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This thesis aims to assess whether the level of the physical condition of patients before lung transplantation affects the length of hospitalization after transplantation. The study includes patients over 18 years of age with both unilateral and bilateral lung transplantation who underwent hospitalization between 2016 and 2018 and underwent a six-minute walk test in the preoperative examination. Data were collected at the 3rd Department of Surgery, First Faculty of Medicine, Charles University in Prague and Motol University Hospital and at the Department of Pneumology, 2nd Faculty of Medicine,
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Pražáková, Markéta. "Klinický význam biomarkerů pro posouzení agresivity a prognozu nemalobuněčného karcinomu plic." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-358410.

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Aim: The aim of this thesis was to measure a large spectrum of biomarkers in serum or plasma of patients with operable stage of NSCLC and to evaluate and compare the clinical utility of these biomarkers in the three most important clinical applications for NSCLC: diagnosis, prognosis and postsurgery follow up care. Patients and methods: Total of 22 biomarkers with the most promising profiles were monitored: 8 standard tumor markers (cytokeratines Cyfra 21-1, TPA, TPS, and MonoTotal, CEA, SCC, TK, Chromogranin A) and 14 potential useful biomarkers including pro-inflammatory cytokines IL-6, IL-8
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Novák, Ondřej. "Vztah usilovné vitální kapacity plic a síly stisku ruky u dětí." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-367830.

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Title: Relationship between forced vital capacity and hand grip strength in children Objectives: One of goals of this thesis is to find out how strong is the connection between the strength of a children's handgrip and the FVC. Another aim is to ascertain what is the age limit to use a handgrip examination to estimate the children's FVC. The last goal is to determine whether a body height, weight and age of a child are crucial to evaluate the handgrip and the FVC. Methods: First part of this thesis is a research and tries to summarize basic information about an issue of dynamometry, spirometry
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Ivánková, Vendula. "Komplexní ošetřovatelská péče u pacienta po transplantaci plic na anesteziologicko resuscitačním oddělení." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-386899.

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Lungs transplantation is a solution for the end stage of pulmonary disease after other therapeutic possibilities that the modern medicine has to offer have been exhausted. The main objective of this thesis is to show postoperative patient care after lung transplantation in the department anesthesiology and resuscitation. A highly specialized complex care and cooperation of various fields is needed. Nurses who take care of these patients must be experienced and skillful. They also need to manage well the nursing care for patients in sedation as well as fully conscious patents. It is also needed
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Moravčíková, Erika. "Exprese regulátorů apoptosomové dráhy a aktivace apoptosomového aparátu u nemalobuněčného karcinomu plic." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-322604.

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Background: The apoptosome pathway is interesting as potential therapeutic target because it plays an important role in the cancer chemotherapy- and biological therapy-induced apoptosis as well as in amplifying the death receptor and cytotoxic-granule-induced pathways. The functionality of apoptosome apparatus in non-small cell lung carcinoma (NSCLC) cells and tissues is often impaired due to defects in apoptosome pathway by changes in expression and/or acquired mutations and/or modifications of apoptosome components or its regulators that play a significant role in cancer cell proliferation a
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CHVOJKOVÁ, Lenka. "Vitální kapacita plic po operaci srdce v Institutu klinické a experimentální medicíny Praha." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-54120.

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Cardiovascular diseases in the Czech Republic represent the main cause of death and significantly contribute to the sickness rate and premature disability. Possibilities of treatment of cardiovascular diseases keep developing increasingly these days. An important part is the follow up spa treatment as well as sufficiently performed effective cardio rehabilitation. The theoretical part characterizes functional examination of the lungs and stress tests in cardiology. Simultaneously it describes early spa treatment and defines quality of life. The aim of the diploma thesis, which deals with the v
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Vošahlíková, Šárka. "Molekulární epidemiologie a vlastnosti bakteriálních původců infekcí plic u pacientů s cystickou fibrózou." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-336168.

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Cystic fibrosis is the most abundant inherited autosomal recessive disease in Caucasian population. Cystic fibrosis is caused by a dysfunction of a transport channel which is responsible for the transport of chloride ions on the apical side of the plasma membrane. Despite the fact that the dysfunction of the transport channel is present in several organs, the most severely affected one is the respiratory system. Because of the ion imbalance, thick sticky mucus is produced on the surface of the airways which then prevents the removal of dust particles and bacteria. The main complications of cys
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Majerová, Barbora. "Studium vlivu inhalačního podání IgY a Fab fragmentů z pohledu iniciace zánětu plic." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-324167.

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Human respiratory system is in constant contact with heterogeneous environmental agents, which can possibly become initiators of inflammatory responses. Mechanical barriers and balance between the innate and adaptive immunity provide protection from external agents without initiation of any inflammatory response. Under certain circumstances, overreaction of the immune system might occur and leads to the production of various inflammatory cytokines and mediators such as TNF-α and GM-CSF factors or interleukins IL-1ß and IL-6. Respiratory system of the human suffering from cystic fibrosis is una
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Rozkoš, Tomáš. "Stanovení optimálního vyšetřovacího algoritmu pro efektivní vyhledávání nemalobuněčných karcinomů plic s přestavbou genu ALK." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-308952.

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(Identification of optimal algorithm for effective diagnostics of non-small cell lung carcinoma with ALK gene rearrangement - implementation of the method and practical experience with routine diagnostics) INTRODUCTION: Smaller subgroup of non-small cell lung carcinoma (NSCLC) is represented by tumours with carcinogenesis iniciated by fusion of ALK gene with another partner (usually EML4). Patients with ALK gene rearrangement treated with ALK inhibitors have significantly prolonged survival. Since ALK gene rearrangement is described according to the current WHO classification in 4-5% of NSCLC,
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Fiala, Ondřej. "Možnosti predikce efektu léčby EGFR tyrozinkinázovými inhibitory u pacientů s pokročilým nemalobuněčným karcinomem plic." Doctoral thesis, 2014. http://www.nusl.cz/ntk/nusl-342344.

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Introduction: Targeted therapy with low molecular-weight tyrosine kinase inhibitors (TKI) directed at inhibition of epidermal growth factor receptor (EGFR) is a novel effective option for systemic treatment of locally-advanced or metastatic non-small cell lung cancer (NSCLC). Finding biomarkers that predict the efficacy of targeted treatment may increase the treatment efficacy and also prolong survival of patients. Aims: To assess the frequency of activating EGFR mutations and KRAS mutations in our patients and their role for prediction of EGFR-TKI treatment efficacy. To compare the efficacy a
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Chrz, Josef. "Porovnání výkonnosti před a po transplantaci plic u dětských pacientů s diagnózou cystická fibróza." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-414861.

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Title: Comparison of performance of pediatric patients with diagnosis of cystic fibrosis before and after a lung transplantation. Objectives: To compare selected parameters of pediatric patients as an index of physical condition in time before and 1 year after transplantation. To compare a group of patients that undergone longtherm intensive physiotherapeutic treatment before transplantation with group of patients that did not using spirometric parameters FVC, FEV1 and BMI. To compare subjective signs of dyspnea between these groups using selected questionnaires. Methods: This theses was atten
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Hodyc, Daniel. "Význam volných kyslíkových radikálů při ischémicko-reperfůzním poškození plic získaných od dárců po srdeční zástavě." Doctoral thesis, 2008. http://www.nusl.cz/ntk/nusl-274145.

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Nagy, Andrea. "Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-329250.

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6 3 SUMMARY Bioindicators of inflammation, oxidative and nitrossative stress in Wistar rats after whole-body and lung irradiation Introduction Radiation pneumonitis and fibrosis limitthe intensity of radiotherapy,increase morbidity and worsen quality of life of patients with lung and breast cancer or Hodgkin's disease. Radiation pneumonitis is an acute inflammatory reaction that resolves either spontaneously or after treatment with corticosteroids. Free radicals play an important role in its etiology. They cause dose-dependent induction of lipoperoxidation, DNA damage, activation of proapoptot
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Fabšíková, Katarína. "Efekt vitamínu E na oxidační stres a na bazální membránu plic potkanů s nedostatkem vitamínu A." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-309363.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Katarína Fabšíková Supervisor: Prof. Ing. Vladimír Wsól, Ph.D. Title of diploma thesis: Effect of vitamin E on oxidative stress and the basement membrane in lungs in vitamin A-deficient rats In the experiment described in this thesis there was being observed the effect of long-term deficiency of vitamin A on the basement membrane in rat lungs. Rats were divided during the experiment into several groups differing in composition of feed and the changes of pulmonary basement membrane w
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Mrázková, Hana. "Role volných kyslíkových radikálů v ischemicko-reperfuzním poškození plic při plicní transplantaci a možnosti prevence radikálového poškození." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-267917.

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 Keywords: Lung Tx, EVLP, NHBD, IR injury, ROS, hypercapnia, gender differences This dissertation thesis deals with a very topical issue of the lack of donor organs for lung transplants. As with other organs, the number of patients on waiting lists in terminal stages of their diseases is also constantly rising but there is not an adequate increase in donor organs. We focused our experimental work on the development of research concerning the solution which is most successful in a long-term perspective, i.e. organ transplants from non- heart-beating donors (NHBDs), in an ex vivo lung transplan
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Šenkeřík, Marian. "Akutní a chronická onemocnění plic a dýchacích cest u dětí: nové bioindikátory a molekulární cíle pro farmakoterapii." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-353498.

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The aim of this thesis was to contribute to the standardization and validation of expiratory flow parameters independent of NO testing, particularly alveolar concentration (CANO) and bronchial NO flux (JawNO) in children and adolescents with allergic respiratory diseases. The thesis was created in the time of increased interest of medicine professionals in non-invasive examination methods and targeted therapeutic influence of inflammation in small airways in asthmatics. After the standardization and validation of clinical benefits, the measurement of concentrations of nitric oxide (FENO) in th
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Belšánová, Barbora. "Optimalizace metodiky pro stanovení volné nádorové DNA v plazmě a její klinické využití u pacientů s karcinomy kolorekta, plic a slinivky břišní." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-368058.

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In current days, examination of circulating tumor DNA (ctDNA) finds new use across different cancers. It is directed at tumor-derived short fragments of DNA present in peripheral blood of patiens (mainly in advanced stages). Due to its minimal invasivity, almost 100 % specificity and relatively high sensitivity in stage IV patients, this approch found its main potential clinical utility especially in early detection of disease relapse or progression after tumor resection (i.e. post-operative follow-up), prediction and monitoring of therapy response and estimation of prognosis. As a result of m
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Kirchnerová, Olga. "Imunologické markery z krve, sputa, BALTe a plicních biopsií při posuzování aktivity a cílenosti léčby chronických zánětlivých a fibrotizujících nemocích plic a průdušek." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-398476.

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The role of biomarkers obtained from serum, sputum, BALF and lung tissue samples in assessing the activity and targeting therapy of chronic inflammatory and fibrotic diseases of the lungs and bronchi Introduction Chronic inflammatory and fibrotic lung and airway diseases represent a heterogeneous group of respiratory tract diseases, both with an initial inflammatory background. Crucial differences in its etiopathogenesis and location significantly influence its clinical manifestation. Considering an extensive progression in science, it is obvious that there is certain heterogeneity among infla
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