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Journal articles on the topic 'PNSA'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Zhang, Aotong, Xin Qi, Fu Du, Guojian Zhang, Dehai Li, and Jing Li. "PNSA, a Novel C-Terminal Inhibitor of HSP90, Reverses Epithelial–Mesenchymal Transition and Suppresses Metastasis of Breast Cancer Cells In Vitro." Marine Drugs 19, no. 2 (2021): 117. http://dx.doi.org/10.3390/md19020117.

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Metastasis accounts for the vast majority of deaths in breast cancer, and novel and effective treatments to inhibit cancer metastasis remain urgently developed. The expression level of heat shock protein 90 (HSP90) in invasive breast cancer tissue is higher than in adjacent non-cancerous tissue. In the present study, we investigated the inhibitory effect of penisuloxazin A (PNSA), a novel C- terminal inhibitor of HSP90, on metastasis of breast cancer cells and related mechanism in vitro. We found that PNSA obviously affected adhesion, migration, and invasion of triple-negative breast cancer (T

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Wadhwa, Harpreet, Ciprian Gradinaru, Gregory J. Gates, M. Safwan Badr, and Jason H. Mateika. "Impact of intermittent hypoxia on long-term facilitation of minute ventilation and heart rate variability in men and women: do sex differences exist?" Journal of Applied Physiology 104, no. 6 (2008): 1625–33. http://dx.doi.org/10.1152/japplphysiol.01273.2007.

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Following exposure to intermittent hypoxia, respiratory motor activity and sympathetic nervous system activity may persist above baseline levels for over an hour. The present investigation was designed to determine whether sustained increases in minute ventilation and sympathovagal (S/V) balance, in addition to sustained depression of parasympathetic nervous system activity (PNSA), were greater in men compared with women following exposure to intermittent hypoxia. Fifteen healthy men and women matched for age, race, and body mass index were exposed to eight 4-min episodes of hypoxia during sus

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3

Martins, NRS. "Influenza Aviária: Uma Revisão dos Últimos Dez Anos." Revista Brasileira de Ciência Avícola 3, no. 2 (2001): 97–140. http://dx.doi.org/10.1590/s1516-635x2001000200001.

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A influenza aviária é doença exótica no Brasil. O sistema de vigilância implementado pelo Programa Nacional de Sanidade Avícola (PNSA) mantém monitoração permanente das aves das principais espécies domésticas, tanto do material genético importado para a indústria avícola, por exemplo, da espécie das galinhas (Gallus gallus formadomestica), perus (Meleagris gallopavo formadomestica), codornas (Coturnix coturnix japonica), patos (Anas), primários (elite), bisavós e avós para postura ou corte, como aves de espécies de exploração mais recente, exóticas, por exemplo avestruzes (Struthio camelus) ou

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Zhang, Aotong, Mingfeng Li, Yanjuan Wang, et al. "Heat shock protein 90 C-terminal inhibitor PNSA promotes anticancer immunology of CD8+ T cells." International Immunopharmacology 121 (August 2023): 110471. http://dx.doi.org/10.1016/j.intimp.2023.110471.

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Shen, Teng, Zhenchao Cui, and Jing Qi. "Logitwise Distillation Network: Improving Knowledge Distillation via Introducing Sample Confidence." Applied Sciences 15, no. 5 (2025): 2285. https://doi.org/10.3390/app15052285.

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While existing knowledge distillation (KD) methods typically force students to mimic teacher features without considering prediction reliability, this practice risks propagating the teacher’s erroneous supervision to the student. To address this, we propose the Logitwise Distillation Network (LDN), a novel framework that dynamically quantifies sample-wise confidence through the ranking of ground truth labels in teacher logits. Specifically, LDN introduces three key innovations: (1) weighted class means that prioritize high-confidence samples, (2) adaptive feature selection based on logit ranki

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6

Liu, Jingyao, Jiashi Zhao, Liyuan Zhang, et al. "DAFLNet: Dual Asymmetric Feature Learning Network for COVID-19 Disease Diagnosis in X-Rays." Computational and Mathematical Methods in Medicine 2022 (August 9, 2022): 1–13. http://dx.doi.org/10.1155/2022/3836498.

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COVID-19 has become the largest public health event worldwide since its outbreak, and early detection is a prerequisite for effective treatment. Chest X-ray images have become an important basis for screening and monitoring the disease, and deep learning has shown great potential for this task. Many studies have proposed deep learning methods for automated diagnosis of COVID-19. Although these methods have achieved excellent performance in terms of detection, most have been evaluated using limited datasets and typically use a single deep learning network to extract features. To this end, the d

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Arslan, Andac, and Evrim Hur. "Electrochemical Characterisation of Poly(aniline-co-N-methylaniline) and Poly(aniline-co-N-ethylaniline) Films on Pencil Graphite Electrode for Supercapacitor Applications." Australian Journal of Chemistry 66, no. 7 (2013): 825. http://dx.doi.org/10.1071/ch13083.

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In this work, poly(aniline-co-N-methylaniline) (co-PNMA) and poly(aniline-co-N-ethylaniline) (co-PNEA) have been electrochemically synthesised on pencil graphite electrode (PGE) surface to use as an electrode material for supercapacitors. The films have been formed from aqueous solution of monomers and sulfuric acid as electrolyte. The copolymer films have been characterised by cyclic voltammetry (CV), Mott-Schottky (MS) analysis, and scanning electron microscopy (SEM). The electrochemical storage properties of uncoated electrode and copolymer coated electrodes (PGE/co-PNMA and PGE/co-PNEA) ha

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8

Luft, Carolina, Natália Evangelista Campos, Mauro Henrique Moraes Vargas, and Márcio Vinícius Fagundes Donadio. "Prenatal stress induces long-lasting effects in lung glucocorticoid receptor gene expression in a sex-dependent manner." Scientia Medica 29, no. 1 (2019): 33192. http://dx.doi.org/10.15448/1980-6108.2019.1.33192.

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AIM: Stressful events during pregnancy may influence respiratory system development, resulting in long-term effects in the offspring. However, little is known on its long-lasting effects upon the expression of important genes in the lungs. Thus, we aimed to evaluate the effect of two different prenatal stress paradigms on lung glucocorticoid receptor (GR) expression in adulthood.METHODS: Pregnant BALB/c mice were divided into 3 groups: control (CON), prenatal stress from the second week of pregnancy (PNS1) and prenatal stress on the last week of pregnancy (PNS2). In both groups (PNS1 and PNS2)

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9

Woelber, Linn, Monika Hampl, Christine zu Eulenburg, et al. "Risk for Pelvic Metastasis and Role of Pelvic Lymphadenectomy in Node-Positive Vulvar Cancer-Results from the AGO-VOP.2 QS Vulva Study." Cancers 14, no. 2 (2022): 418. http://dx.doi.org/10.3390/cancers14020418.

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The need for pelvic treatment in patients with node-positive vulvar cancer (VSCC) and the value of pelvic lymphadenectomy (LAE) as a staging procedure to plan adjuvant radiotherapy (RT) is controversial. In this retrospective, multicenter analysis, 306 patients with primary node-positive VSCC treated at 33 gynecologic oncology centers in Germany between 2017 and 2019 were analyzed. All patients received surgical staging of the groins; nodal status was as follows: 23.9% (73/306) pN1a, 23.5% (72/306) pN1b, 20.4% (62/306) pN2a/b, and 31.9% (97/306) pN2c/pN3. A total of 35.6% (109/306) received pe

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10

Zheng, Junwen, Pu Yang, Yan Tang, Zishu Pan, and Dongchi Zhao. "Respiratory Syncytial Virus Nonstructural Proteins Upregulate SOCS1 and SOCS3 in the Different Manner from Endogenous IFN Signaling." Journal of Immunology Research 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/738547.

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Respiratory syncytial virus (RSV) infection upregulates genes of the suppressor of cytokine signaling (SOCS) family, which utilize a feedback loop to inhibit type I interferon dependent antiviral signaling pathway. Here, we reconstituted RSV nonstructural (NS) protein expression plasmids (pNS1, pNS2, and pNS1/2) and tested whether NS1 or NS2 would trigger SOCS1 and SOCS3 protein expression. These NS proteins inhibited interferon- (IFN-)αsignaling through a mechanism involving the induction of SOCS1 and SOCS3, which appeared to be different from autocrine IFN dependent. NS1 induced both SOCS1 a

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11

Gindhart, Amy M., Cora Lind, and Mark Green. "Polymorphism in the negative thermal expansion material magnesium hafnium tungstate." Journal of Materials Research 23, no. 1 (2008): 210–13. http://dx.doi.org/10.1557/jmr.2008.0013.

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Magnesium hafnium tungstate [MgHf(WO4)3] was synthesized by high-energy ball milling followed by calcination. The material was characterized by variable- temperature neutron and x-ray diffraction. It crystallized in space group P21/a below 400 K and transformed to an orthorhombic structure at higher temperatures. The orthorhombic polymorph adopted space group Pnma, instead of the Pnca structure commonly observed for other A2(MO4)3 materials (A = trivalent metal, M = Mo, W). In contrast, the monoclinic polymorphs appeared to be isostructural. Negative thermal expansion was observed in the ortho

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12

Gummow, Jason, Makutiro G. Masavuli, Zelalem A. Mekonnen, et al. "Safety Profile of a Multi-Antigenic DNA Vaccine Against Hepatitis C Virus." Vaccines 8, no. 1 (2020): 53. http://dx.doi.org/10.3390/vaccines8010053.

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Despite direct acting antivirals (DAAs) curing >95% of individuals infected with hepatitis C (HCV), in order to achieve the World Health Organization HCV Global Elimination Goals by 2030 there are still major challenges that need to be overcome. DAAs alone are unlikely to eliminate HCV in the absence of a vaccine that can limit viral transmission. Consequently, a prophylactic HCV vaccine is necessary to relieve the worldwide burden of HCV disease. DNA vaccines are a promising vaccine platform due to their commercial viability and ability to elicit robust T-cell-mediated immunity (CMI). We h

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13

Nasim, M., and S. D. Orfi. "EVOLUTION AND DEVELOPMENT OF NUCLEAR SAFETY REGIME IN PAKISTAN." Nucleus 42, no. 1-4 (2020): 67–72. https://doi.org/10.71330/nucleus.42.01-4.1049.

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In Pakistan a gradual evolution and development of nuclear safety regime, starting from its very early stage to a full-fledged independent authority has taken place. The evolution process took more than four decades and has been completed in six different stages, i.e. (i) with no legal basis (April 1956 â€“ December 1965), (ii) under Atomic Energy Act of 1965 (December 1965 â€“ January 1984), (iii) under the Nuclear Safety Act of 1984 (January 1984 â€“ September 1990), (iv) with support of 1990 regulations (September 1990 â€“ October 1994), (v) with a quasi independent regulatory board (Octobe

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14

Wang, Hai-Rong, Fang-Yuan Chen, Hua Zhong, et al. "PNAS-2’s Subcullar Location in Leukemic Cell Is Abnormal and Its Relation with Leukemogenesis." Blood 110, no. 11 (2007): 4299. http://dx.doi.org/10.1182/blood.v110.11.4299.4299.

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Abstract We used functional analyses of PNAS-2 by RNAi and RNA overexpression and demonstrated PNAS-2 as an anti-apoptotic gene. PNAS-2 expression was significantly increased in de novo and relapsed acute leukemia patients, but in patients in complete remission, the expression of PNAS-2 decreased to the levels comparable to those found in normal controls. In carcinomas, PNAS-2 expression was not up-regulated, indicating that PNAS-2 overexpression was specific for leukemia. So we hypothesized that PNAS-2 could act as an oncogene and anti-apoptotic gene which probably participates leukemogenesis

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15

Kumar, Bijender, Ruchir Priyadarshi, Sauraj, et al. "Nanoporous Sodium Carboxymethyl Cellulose-g-poly (Sodium Acrylate)/FeCl3 Hydrogel Beads: Synthesis and Characterization." Gels 6, no. 4 (2020): 49. http://dx.doi.org/10.3390/gels6040049.

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Novel sodium carboxymethyl cellulose-g-poly (sodium acrylate)/Ferric chloride (CMC-g-PNaA/FeCl3) nanoporous hydrogel beads were prepared based on the ionic cross-linking between CMC-g-PNaA and FeCl3. The structure of CMC and CMC-g-PNaA were elucidated by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy, and the elemental composition was analyzed by energy dispersive X-ray analysis (EDX). The physicochemical properties of the CMC-g-PNaA/FeCl3 hydrogel beads were analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force

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16

Wang, Jin, Hua Qiu, Bo Cheng, Fan Zhang, and Shuhua Qi. "Preparation of a monodisperse poly (N-phenylmaleimide–acrylonitrile–styrene) structural nanolatex for heat-resistant modification of PVC." Journal of Thermoplastic Composite Materials 32, no. 3 (2018): 409–23. http://dx.doi.org/10.1177/0892705718780976.

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A monodisperse poly ( N-phenylmaleimide–acrylonitrile–styrene) (PNAS) nanolatex was synthesized via seed microemulsion polymerization. The obtained PNAS nanolatex was then directly used as an organic nanofiller to prepare polyvinyl chloride (PVC)/PNAS hybrid composite through water blending and melt compounding. The characteristics of PNAS nanolatex were analyzed by Fourier transform infrared (FTIR) spectrometer, elemental analysis, scanning electron microscope, transmission electron microscope (TEM), dynamic laser lighting scattering (DLS), differential scanning calorimetry (DSC), and thermog

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17

Dawid, I. B., M. F. Singer, and F. R. Zwanzig. "PNAS Reviewing Procedures." Science 243, no. 4897 (1989): 1419. http://dx.doi.org/10.1126/science.243.4897.1419-c.

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18

Duesberg, P. "Duesberg's PNAS paper." Science 243, no. 4895 (1989): 1125. http://dx.doi.org/10.1126/science.2922599.

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Dawid, I., M. Singer, and F. Zwanzig. "PNAS reviewing procedures." Science 243, no. 4897 (1989): 1419. http://dx.doi.org/10.1126/science.2928774.

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20

Litzow, Mark R. "PNAs for AML." Blood 102, no. 7 (2003): 2315. http://dx.doi.org/10.1182/blood-2003-07-2515.

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21

Cozzarelli, N. R. "PNAS Early Edition." Proceedings of the National Academy of Sciences 97, no. 2 (2000): 525. http://dx.doi.org/10.1073/pnas.97.2.525.

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22

Xie, Boqin, Chenjuan Ma, and Junqiao Wang. "Independent and Combined Relationships of Perceived Neighborhood Social Cohesion and Physical Frailty on Functional Disability in Community-Dwelling Older Adults." International Journal of Environmental Research and Public Health 17, no. 16 (2020): 5912. http://dx.doi.org/10.3390/ijerph17165912.

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Functional disability and physical frailty (PF) are debilitating geriatric conditions. Previous studies have suggested both perceived neighborhood social cohesion (PNSC) and PF can influence functional disability and may have an interactive effect too. This cross-sectional study aims to examine the independent and combined relationships of PF and PNSC on functional disability in community-dwelling older adults in Shanghai, China. A total of 1616 older adults aged ≥ 75 years were recruited using multistage sampling. Results showed that prefrailty, frailty (using the modified frailty phenotype c

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23

Guenther, Mariana, and Maryane Caroline Pedroza de Almeida. "A Educação Ambiental no Brasil: marcos legais e implementação curricular." Pesquisa em Educação Ambiental 18, no. 1 (2023): 1–15. http://dx.doi.org/10.18675/2177-580x.2023-17629.

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Desde a Revolução Industrial, no século XVIII, nossa relação predatória com o meio ambiente vem se agravando, levando à extinção dos recursos naturais e a graves problemas de poluição. Diante desse cenário, a partir da década de 1950, houve muitas discussões, negociações, e grandes avanços foram conquistados no sentido de propor soluções para minimizar esses impactos. Um novo conceito de desenvolvimento econômico aliado à percepção de que a solução para os problemas ambientais está na educação moldaram a legislação ambiental no final do século XX. Esta pesquisa traz um panorama histórico das o

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Zhou, Jingyi, Erwen Xu, Kang Shao, et al. "Circulating platelet-neutrophil aggregates as risk factor for deep venous thrombosis." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 5 (2019): 707–15. http://dx.doi.org/10.1515/cclm-2018-0909.

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Abstract Background Platelet-neutrophil aggregates (PNAs) are fundamental mechanisms linking hemostasis and inflammatory processes. Elevated level of PNAs have been reported in inflammatory diseases and coronary artery diseases. However, studies on the correlation between PNAs formation and deep venous thrombosis (DVT) are not available. Methods A total of 92 participants were involved in this study, including 32 cases with DVT and 60 cases without DVT. Blood samples coagulated by K2-EDTA or sodium citrate were prepared for blood cell count and blood smears. PNAs and platelet activation were m

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Sanjaya, Eli Hendrik. "INSERSI GEN pncA KE DALAM PLASMID pGEM-T." Jurnal Kimia Riset 1, no. 2 (2016): 135. http://dx.doi.org/10.20473/jkr.v1i2.3092.

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Abstract. Multidrug-resistant tuberculosis (MDR-TB) is among the most worrisome elements of the pandemic of antibiotic resistance. As the first line drug, pyrazinamide is often used to treat TB desease so there are many case of TB resistant to pyrazinamide. The previous research show that pncA gene of isolate L20 MDR-TB have mutated T539C. That mutation propose as the cause of resistance M. tuberculosis to pyrazimanide at the genetic level. For make sure the resistance mechanism, we have to get the pure PZAse and crystalization so the 3D structure can be determined by X-ray defraction. The fir

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Jewett, Mollie W., Sunny Jain, Angelika K. Linowski, Amit Sarkar, and Patricia A. Rosa. "Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA." Microbiology 157, no. 10 (2011): 2831–40. http://dx.doi.org/10.1099/mic.0.051706-0.

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The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD+ homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle. Mammals lack nicotinamidases and therefore PncA may serve as a therapeutic target for Lyme disease. Contrary to the in vivo importance of PncA, the current annotation for the pncA ORF suggests that the encoded protein may be inactive due to the absence of an N-term

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Koga, Aoi, Takumi Yamasaki, Shuhei Hayashi, Shinjiro Yamamoto, and Hitoshi Miyasaka. "Isolation of purple nonsulfur bacteria from the digestive tract of ayu (Plecoglossus altivelis)." Bioscience, Biotechnology, and Biochemistry 86, no. 3 (2022): 407–12. http://dx.doi.org/10.1093/bbb/zbac001.

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ABSTRACT Purple nonsulfur bacteria (PNSB) reportedly have probiotic effects in fish, but whether they are indigenous in the digestive tract of fish is a question that requires answering. We attempted to isolate PNSB from the digestive tract of ayu (Plecoglossus altivelis) from the Kuma River (Kumamoto, Japan) and successfully isolated 12 PNSB strains. All the isolated PNSB belonged to the genus Rhodopseudomonas. Five Rhodopseudomonas strains were also isolated from the soil samples collected along the Kuma River. The phylogenetic tree based on the partial sequence of pufLM gene indicated that

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Fan, Qingyang, Changchun Chai, Qun Wei, et al. "A New Phase of GaN." Journal of Chemistry 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/8612892.

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The structural, mechanical, and electronic properties of the orthorhombic GaN (Pnma-GaN) are investigated at ambient pressure by using first-principles calculations method with the ultrasoft pseudopotential scheme. The elastic constants and phonon calculations reveal Pnma-GaN is mechanically and dynamically stable at ambient pressure. The calculated Young modulus of Pnma-GaN is 170 GPa, which is the three-fifths of wurtzite-GaN. Electronic structure study shows that Pnma-GaN is a direct semiconductor with band gap of 1.847 eV. The anisotropic calculation shows that wurtzite-GaN has a smaller e

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29

Shao, Chao-Gang, Hui-Juan Lü, Jian-Hua Wu, and Zu-Xun Gong. "Nucleic Acid Binding Activity of Pns6 Encoded by Genome Segment 6 of Rice Ragged Stunt Oryzavirus." Acta Biochimica et Biophysica Sinica 36, no. 7 (2004): 457–66. http://dx.doi.org/10.1093/abbs/36.7.457.

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Abstract The ORF of genome segment 6 (S6) of rice ragged stunt oryzavirus (RRSV) Philippines isolate was cloned and sequenced based on the S6 sequence of the Thailand isolate. Pns6, the 71 kD product of S6 expressed in E. coli, was demonstrated to be a viral non-structural protein of RRSV by Western blotting. The gel mobility shift assays showed that Pns6 had nucleic acid binding activity. Pns6 could interact with single-and double-stranded forms of DNA and RNA, showing a preference for single-stranded nucleic acid and a slight preference for RRSV ssRNA over the rice ssRNA, as demonstrated by

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Akita, Fusamichi, Naoyuki Miyazaki, Hiroyuki Hibino, et al. "Viroplasm matrix protein Pns9 from rice gall dwarf virus forms an octameric cylindrical structure." Journal of General Virology 92, no. 9 (2011): 2214–21. http://dx.doi.org/10.1099/vir.0.032524-0.

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The non-structural Pns9 protein of rice gall dwarf virus (RGDV) accumulates in viroplasm inclusions, which are structures that appear to play an important role in viral morphogenesis and are commonly found in host cells infected by viruses in the family Reoviridae. Immunofluorescence and immunoelectron microscopy of RGDV-infected vector cells in monolayers, using antibodies against Pns9 of RGDV and expression of Pns9 in Spodoptera frugiperda cells, demonstrated that Pns9 is the minimal viral factor necessary for formation of viroplasm inclusion during infection by RGDV. When Pns9 in solution w

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Wilson, Philip M., W. Todd Rogers, Wendy M. Rodgers, and T. Cameron Wild. "The Psychological Need Satisfaction in Exercise Scale." Journal of Sport and Exercise Psychology 28, no. 3 (2006): 231–51. http://dx.doi.org/10.1123/jsep.28.3.231.

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The purpose of this study was to provide initial construct validity evidence for scores derived from the Psychological Need Satisfaction in Exercise (PNSE) scale, a multidimensional instrument designed to measure perceived psychological need satisfaction in line with Deci and Ryanʼs (1985, 2002) self-determination theory (SDT). Participants in two studies (n1 = 426; n2 = 581) completed the PNSE along with proxy measures of need satisfaction. The results of an exploratory factor analysis in Study 1 supported the retention of a 3-factor measurement model underpinning PNSE responses. Confirmatory

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Elkaeed, Eslam B., Reda G. Yousef, Hazem Elkady, et al. "A New Theobromine-Based EGFRWT and EGFRT790M Inhibitor and Apoptosis Inducer: Design, Semi-Synthesis, Docking, DFT, MD Simulations, and In Vitro Studies." Processes 10, no. 11 (2022): 2290. http://dx.doi.org/10.3390/pr10112290.

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The essential pharmacophoric structural properties were applied to design a new derivative of theobromine as an antiangiogenic EGFR inhibitor. The designed candidate is a (para-nitrophenyl)acetamide derivative of the natural alkaloid, theobromine (T-2-PNPA). The potentialities of T-2-PNPA to inhibit the EGFR protein were studied computationally in an extensive way. Firstly, the molecular docking against EGFRWT and EGFRT790M demonstrated T-2-PNPA’s capabilities of binding with the targeted receptors. Then, the MD experiments (for 100 ns) illustrated through six different studies the changes tha

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Petushkova, Ekaterina, Ekaterina Mayorova, and Anatoly Tsygankov. "TCA Cycle Replenishing Pathways in Photosynthetic Purple Non-Sulfur Bacteria Growing with Acetate." Life 11, no. 7 (2021): 711. http://dx.doi.org/10.3390/life11070711.

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Purple non-sulfur bacteria (PNSB) are anoxygenic photosynthetic bacteria harnessing simple organic acids as electron donors. PNSB produce a-aminolevulinic acid, polyhydroxyalcanoates, bacteriochlorophylls a and b, ubiquinones, and other valuable compounds. They are highly promising producers of molecular hydrogen. PNSB can be cultivated in organic waste waters, such as wastes after fermentation. In most cases, wastes mainly contain acetic acid. Therefore, understanding the anaplerotic pathways in PNSB is crucial for their potential application as producers of biofuels. The present review addre

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Xie, Boqin. "SOCIAL COHESION AFFECTS THE ASSOCIATION BETWEEN FRAILTY AND DISABILITY IN COMMUNITY-DWELLING OLDER ADULTS." Innovation in Aging 3, Supplement_1 (2019): S782. http://dx.doi.org/10.1093/geroni/igz038.2876.

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Abstract The relationships between physical frailty and perceived neighborhood social cohesion (PNSC) and functional disability among community-dwelling older adults are poorly understood. This study aims to (1) examine the associations of frailty and PNSC with disability; and (2) evaluate low PNSC as a risk factor in the association between frailty and disability. A sample of 1645 older adults using multi-stage sampling method in Shanghai were randomly selected in this cross-sectional study. Frailty operationalized as Cardiovascular Health Study criteria (OR=2.4, 95%CI 1.16-4.96 for pre-frail

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Liu, Yinglei, Zhe Chen, Jun You, Yanli Zheng, and Haifeng Qiao. "Paraneoplastic Ma antigen 5 promotes cellular processes of primary cells in ovarian endometriosis." African Journal of Reproductive Health 29, no. 4 (2025): 37–48. https://doi.org/10.29063/ajrh2025/v29i4.4.

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This study investigates the role of paraneoplastic Ma antigen 5 (PNMA 5), a member of the PNMA family of proteins, in ovarian endometriosis (EM). These proteins are known to play a significant role in various physiological activities and are highly expressed in cells undergoing carcinogenesis, where they influence cell cycle, apoptosis, and other cellular processes. However, the involvement of PNMA 5 in ovarian EM has not been fully understood. To explore this, the study analyzed PNMA 5 levels in both normal and ectopic endometrial tissues from ovarian EM patients using immunohistochemistry. S

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Grossman, Murray, Jenifer Mickanin, Kris Onishi, et al. "Progressive Nonfluent Aphasia: Language, Cognitive, and PET Measures Contrasted with Probable Alzheimer's Disease." Journal of Cognitive Neuroscience 8, no. 2 (1996): 135–54. http://dx.doi.org/10.1162/jocn.1996.8.2.135.

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The purpose of this study was to compare the language and cognitive profiles of four progressive nonfluent aphasia (PNFA) patients with 25 probable Alzheimer's disease (pAD) patients, and to identify the distinct cortical defects associated with cognitive deficits in PNFA using positron emission tomography (PET). Longitudinal observations of PNFA patients revealed progressively telegraphic speech and writing and a gradual deterioration of sentence comprehension, but memory and visual functioning were relatively preserved. Direct contrast with PAD patients revealed that PNFA patients are signif

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Abt, Corina, Lisa Marie Gerlach, Jana Bull, Anette Jacob, Bernd Kreikemeyer, and Nadja Patenge. "Pyrenebutyrate Enhances the Antibacterial Effect of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pyogenes." Microorganisms 11, no. 9 (2023): 2131. http://dx.doi.org/10.3390/microorganisms11092131.

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Antisense peptide nucleic acids (PNAs) inhibit bacterial growth in several infection models. Since PNAs are not spontaneously taken up by bacteria, they are often conjugated to carriers such as cell-penetrating peptides (CPPs) in order to improve translocation. Hydrophobic counterions such as pyrenebutyrate (PyB) have been shown to facilitate translocation of peptides over natural and artificial membranes. In this study, the capability of PyB to support translocation of CPP-coupled antisense PNAs into bacteria was investigated in Streptococcus pyogenes and Streptococcus pneumoniae. PyB enhance

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Scorpio, A., P. Lindholm-Levy, L. Heifets, et al. "Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis." Antimicrobial Agents and Chemotherapy 41, no. 3 (1997): 540–43. http://dx.doi.org/10.1128/aac.41.3.540.

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Pyrazinamide (PZA) is a first-line drug for short-course tuberculosis therapy. Resistance to PZA is usually accompanied by loss of pyrazinamidase (PZase) activity in Mycobacterium tuberculosis. PZase converts PZA to bactericidal pyrazinoic acid, and the loss of PZase activity is associated with PZA resistance. The gene (pncA) encoding the M. tuberculosis PZase has recently been sequenced, and mutations in pncA were previously found in a small number of PZA-resistant M. tuberculosis strains. To further understand the genetic basis of PZA resistance and determine the frequency of PZA-resistant s

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Vera, Yeni, Bintang YM Sinaga, Dedi Ardinata, and Yahwardiah Siregar. "The Effect of pncA Gene Mutation of Mycobacterium Tuberculosis to Transaminase and Uric Acid Serum in MDR TB Patient." Jurnal Respirologi Indonesia 38, no. 3 (2018): 150–57. http://dx.doi.org/10.36497/jri.v38i3.4.

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Bacground: The common side effects of PZA treatment is the occurrence of hepatotoxicity and blocking the secretion of uric acid. This study aims to determine the effect of the pncA gene mutation of Mycobacterium tuberculosis to serum transaminase and serum uric acid in patients with MDR TB who had receive therapy with PZA. Methods: Quasi-experimental test was conducted at MDR TB polyclinic in H. Adam Malik Medan Hospital of 25 patients with MDR TB. Mutations of genes was assessed by PCR-RFLP method and data of serum transaminase and serum uric acid retrieved from the me

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Urick, Tonia, Chien I-Chang, Ellen Arena, WenLian Xu, Maurice J. Bessman, and Carmel G. Ruffolo. "The pnhA Gene of Pasteurella multocida Encodes a Dinucleoside Oligophosphate Pyrophosphatase Member of the Nudix Hydrolase Superfamily." Journal of Bacteriology 187, no. 16 (2005): 5809–17. http://dx.doi.org/10.1128/jb.187.16.5809-5817.2005.

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ABSTRACT The pnhA gene of Pasteurella multocida encodes PnhA, which is a member of the Nudix hydrolase subfamily of dinucleoside oligophosphate pyrophosphatases. PnhA hydrolyzes diadenosine tetra-, penta-, and hexaphosphates with a preference for diadenosine pentaphosphate, from which it forms ATP and ADP. PnhA requires a divalent metal cation, Mg2+ or Mn2+, and prefers an alkaline pH of 8 for optimal activity. A P. multocida strain that lacked a functional pnhA gene, ACP13, was constructed to further characterize the function of PnhA. The cellular size of ACP13 was found to be 60% less than t

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Hameed, H. M. Adnan, Cuiting Fang, Zhiyong Liu, et al. "The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates." Microorganisms 13, no. 6 (2025): 1401. https://doi.org/10.3390/microorganisms13061401.

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Pyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZAR) primarily related to pncA mutations. However, discordance between phenotypic resistance and conventional pncA-based molecular diagnostics challenges diagnostic accuracy. This study investigates discrepancies between phenotypic and genotypic resistance profiles among Mycobacterium tuberculosis (Mtb) clinical isolates. Fifty-three Mtb isolates from Guangzhou Chest Hospital were tested for PZA resistance using the BACTEC MGIT 960 system and PZase activity assay. Thirty-one phenotypically PZAR strains were

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Kostic, Aleksandar, Dragan Stojanov, Ivan Stefanovic, et al. "Complications after angiogram-negative subarachnoid haemorrhage: Comparative study of pretruncal and nonpretruncal hemorrhage patients." Srpski arhiv za celokupno lekarstvo 140, no. 1-2 (2012): 8–13. http://dx.doi.org/10.2298/sarh1202008k.

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Introduction. Subarachnoid haemorrhages (SAH) of unknown aetiology usually have a mild clinical presentation, favourable outcome and low complication rate. Objective. The aim of this study was to analyze the complications in two forms of angiogram-negative spontaneous SAH: pretruncal (PNSAH) and nonpretruncal (NPNSAH). Methods. The study group involved 18 patients with PNSAH and 16 patients with NPNSAH. CT scan was done within 72 hours from bleeding. All patients underwent four-vessel cerebral angiography. Repeat angiography was performed in five PNSAH and all NPNSAH patients. Results. Twenty-

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Cesar, Ary Gustavo da Silva, Fernanda Tomassoni, and Edilson Pontarolo. "ANALYSIS OF ENVIRONMENTAL EDUCATION IN AN INTEGRAL TECHNICAL CITIZENSHIP SCHOOL (ECIT) FROM JOÃO PESSOA, NORTHEAST BRAZIL." Environmental Smoke 6, no. 1 (2023): 53–63. http://dx.doi.org/10.32435/envsmoke.20236153-63.

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This work sought to present how Environmental Education is presented in the didactic pedagogical activities of ECIT João Roberto Borges de Souza, according to the Resolution CNE/CP nº. 2/2012 that establishes National Curriculum Guidelines for Environmental Education. It is important to highlight that the insertion of the environmental issue in the curricula of basic education schools has been recommended by several factors that contributed to public policies in Brazil, among them the National Policy for the Environment (PNMA), the Law of Directives and Bases of National Education (LDBEN), the

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Huu, Tran Ngoc, Tran Thi Ngoc Giau, Phan Ngoc Ngan, Tran Thi Bich Van, and Nguyen Quoc Khuong. "Potential of Phosphorus Solubilizing Purple Nonsulfur Bacteria Isolated from Acid Sulfate Soil in Improving Soil Property, Nutrient Uptake, and Yield of Pineapple (Ananas comosus L. Merrill) under Acidic Stress." Applied and Environmental Soil Science 2022 (November 26, 2022): 1–13. http://dx.doi.org/10.1155/2022/8693479.

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This study aimed to (i) evaluate purple nonsulfur bacteria (PNSB) strains possessing the highest phosphorus (P) solubilizing capacity in field and (ii) determine the efficacy of PNSB biofertilizers in improving soil quality, P uptake, growth, and yield of pineapple cultivated in acid sulfate soil (ASS). A field experiment was conducted in a completely randomized block design with two factors, including the first factor as P fertilizer levels (0, 50, 75, and 100% P) based on recommended fertilizer formula (RFF) and the second factor as supplementation of biofertilizers containing P solubilizing

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Crawford, Andrew J., and Silvia Restrepo. "Comentario sobre el artículo EBP-Colombia and the bioeconomy: Genomics in the service of biodiversity conservation and sustainable development de Joseph E. A. Huddart, Andrew J. Crawford, Arturo L. Luna-Tapia, Silvia Restrepo y Federica Di Palma." Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales 46, no. 178 (2022): 283–84. http://dx.doi.org/10.18257/raccefyn.1656.

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Rohmadi, Rohmadi, Muadil Faizin, R. Dedy Chairil Zain, Yenni Samri Juliati Nasution, and Suhardiman Suhardiman. "Optimizing Prenuptial Agreements for Asset Protection: A Maqashid Sharia Based Approach." Al-Istinbath: Jurnal Hukum Islam 9, no. 2 (2024): 411–34. https://doi.org/10.29240/jhi.v9i2.11064.

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This research aims to explore the optimization of PNAs for asset protection by integrating the principles of maqashid sharia, which emphasize the protection of religion, life, intellect, progeny, and wealth. The high divorce rates in Indonesia, mainly due to online gambling, highlight the vulnerability of asset protection at the beginning of marriage and underscore the importance of prenuptial agreements (PNAs). This research uses a qualitative approach with normative juridical analysis methods. Secondary data was obtained through critical analysis of related literature, including the Indonesi

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Pinheiro, Renan Aguera, Ana Kober Leite, Beatriz Godoi Cavalheiro, Evandro Sobroza de Mello, Luiz Paulo Kowalski, and Leandro Luongo Matos. "Incidental Node Metastasis as an Independent Factor of Worse Disease-Free Survival in Patients with Papillary Thyroid Carcinoma." Cancers 15, no. 3 (2023): 943. http://dx.doi.org/10.3390/cancers15030943.

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Introduction: Papillary thyroid carcinoma (PTC) have high node metastasis rates. Occasionally after thyroidectomy, the pathological report reveals node metastasis unintentionally resected. The present study aimed to evaluate the prognosis of these patients. Methods: A retrospective cohort of patients submitted to thyroidectomy with or without central compartment neck dissection (CCND) due to PTC with a minimum follow-up of five years. Results: A total of 698 patients were included: 320 Nx, 264 pN0-incidental, 37 pN1a-incidental, 32 pN0-CCND and 45 pN1a-CCND. Patients with node metastasis were

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Shrestha, Dipti, Bhagwan Maharjan, Jeewan Thapa, et al. "Detection of Mutations in pncA in Mycobacterium tuberculosis Clinical Isolates from Nepal in Association with Pyrazinamide Resistance." Current Issues in Molecular Biology 44, no. 9 (2022): 4132–41. http://dx.doi.org/10.3390/cimb44090283.

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Without the proper information on pyrazinamide (PZA) susceptibility of Mycobacterium tuberculosis (MTB), PZA is inappropriately recommended for the treatment of both susceptible and multidrug-resistant tuberculosis (MDR-TB) in Nepal. This study aimed to collect information regarding PZA susceptibility in MTB isolates from Nepal by analyzing pncA and its upstream regulatory region (URR). A total of 211 MTB isolates were included in this study. Sequence analysis of pncA and its URR was performed to assess PZA resistance. First-line drug susceptibility testing, spoligotyping, and sequence analysi

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Lacaze, B. "Filtering from PNS2 Sampling." Sampling Theory in Signal and Image Processing 11, no. 1 (2012): 43–53. http://dx.doi.org/10.1007/bf03549548.

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Feder, Toni. "PNAS Opens its Doors." Physics Today 49, no. 8 (1996): 59. http://dx.doi.org/10.1063/1.2807724.

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