Log in

Relevant bibliographies by topics / Podophyllotoxin

Contents

Journal articles
Dissertations / Theses
Books
Book chapters
Conference papers

Academic literature on the topic 'Podophyllotoxin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Podophyllotoxin.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Podophyllotoxin"

1

Lear, Yvonne, and Tony Durst. "Synthesis and biological evaluation of carbon-substituted C-4 derivatives of podophyllotoxin." Canadian Journal of Chemistry 74, no. 9 (1996): 1704–8. http://dx.doi.org/10.1139/v96-187.

Full text

Abstract:

Several C-4 carbon-substituted analogues of podophyllotoxin, 1, were prepared by treatment of 1 with allyltrimethylsilane or trimethylsilylcyanide in the presence of boron trifluoride etherate. Alternatively, carbon substituents were introduced via additions to the carbobenzyloxy-protected C-4′-dimethylated podophyllotoxone. These 4′-dimethylated derivatives showed promising in vitro antitumour activity and were equally active against human colon cell line HT116 and two multidrug resistant cell lines. The alcohol 6 was evaluated in vivo but was found to be inactive. Key words: podophyllotoxin

APA, Harvard, Vancouver, ISO, and other styles

2

Sharma, Sameer, and Sudhakar Malla. "Molecular Docking Studies of Podophyllotoxin and Its Derivatives against Metabolic Enzymes Regarding Anticancer Therapeutic Strategies." Recent Advances in Biology and Medicine 6 (2020): 1. http://dx.doi.org/10.18639/rabm.2020.1110185.

Full text

Abstract:

The objective of this study was to analyze the molecular characteristics of the podophyllotoxins and its derivatives with the metabolic enzymes and regulate the designing of therapeutic mechanism against malignant cells. One such inhibitor is podophyllotoxin with anticancer activity because of the capability to stop the metabolic enzymes. In this study, we undertook the in silico analysis with respect to molecular docking podophyllotoxin and its derivatives using the Patchdock server. Moreover, drug likeness of podophyllotoxin, etoposide, and teniposide was investigated using Lipinski filter a

APA, Harvard, Vancouver, ISO, and other styles

3

Jin, Lu, Zhijun Song, Fang Cai, Lijun Ruan, and Renwang Jiang. "Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins." Molecules 28, no. 1 (2022): 302. http://dx.doi.org/10.3390/molecules28010302.

Full text

Abstract:

Plants containing podophyllotoxin and its analogues have been used as folk medicines for centuries. The characteristic chemical structures and strong biological activities of this class of compounds attracted attention worldwide. Currently, more than ninety natural podophyllotoxins were isolated, and structure modifications of these molecules were performed to afford a variety of derivatives, which offered optimized anti-tumor activity. This review summarized up to date reports on natural occurring podophyllotoxins and their sources, structural modification and biological activities. Special a

APA, Harvard, Vancouver, ISO, and other styles

4

Damayanthi, Yalamati, and J. William Lown. "Podophyllotoxins: Current Status and Recent Developments." Current Medicinal Chemistry 5, no. 3 (1998): 205–52. http://dx.doi.org/10.2174/0929867305666220314204426.

Full text

Abstract:

Podophyllotoxin is a natural product isolated from Podophyllum peltatum and Podophyllum emodi and has long been known to possess medicinal properties. Etoposide (VP-16), a podophyllotoxin derivative, is currently in clinical use in the treatment of many cancers, particularly small cell lung carcinoma and testicular cancer. This compound arrests cell growth by inhibiting DNA tope isomerase II, which causes double strand breaks in DNA. VP-16 does not inhibit tubulin polymerization, however, its parent compound, podophyllotoxin, which has no inhibitory activity against DNA topoisomerase II, is a

APA, Harvard, Vancouver, ISO, and other styles

5

Xu, Shengnan, Xinru Li, Shi Liu, Peilin Tian, and Dengwu Li. "Juniperus sabina L. as a Source of Podophyllotoxins: Extraction Optimization and Anticholinesterase Activities." International Journal of Molecular Sciences 23, no. 18 (2022): 10205. http://dx.doi.org/10.3390/ijms231810205.

Full text

Abstract:

Juniperus sabina L. (J. sabina) has been an important plant in traditional medicine since ancient times. Its needles are rich in podophyllotoxin, a precursor compound to anti-tumor drugs. However, no systematic research has been done on J. sabina as a source of podophyllotoxins or their biological action. Hence, extracts of podophyllotoxin and deoxypodophyllotoxin were the main optimization targets using the Box–Behnken design (BBD) and response surface methodology (RSM). The total phenol content and antioxidant activity of J. sabina needle extract were also optimized. Under the optimal proces

APA, Harvard, Vancouver, ISO, and other styles

6

Che, Zhiping, Yuee Tian, Jinming Yang, et al. "Screening of Insecticidal Activity of Podophyllotoxin Analogues against Athetis dissimilis." Natural Product Communications 14, no. 1 (2019): 1934578X1901400. http://dx.doi.org/10.1177/1934578x1901400131.

Full text

Abstract:

As our ongoing work on research of natural-product-based insecticidal agents, eighteen podophyllotoxin analogues with diverse chemical structures were evaluated for their insecticidal activities against the pre-fourth-instar larvae of Athetis dissimilis Hampson in vivo at the concentration of 1 mg/mL. Among all the reported analogues, compounds 6, 8, 12, 13, 15 and 17 showed more potent insecticidal activities than matrine, quinine and toosendanin, three commercial plant secondary metabolites. 2′,6′-Dichloropodophyllotoxin (8) and 2′,6′-dichloroepipodophyllotoxin (13) exhibited the most pronou

APA, Harvard, Vancouver, ISO, and other styles

7

Yang, Zhongtao, Zitong Zhou, Xiai Luo, et al. "Design and Synthesis of Novel Podophyllotoxins Hybrids and the Effects of Different Functional Groups on Cytotoxicity." Molecules 27, no. 1 (2021): 220. http://dx.doi.org/10.3390/molecules27010220.

Full text

Abstract:

Development of novel anticancer therapeutic candidates is one of the key challenges in medicinal chemistry. Podophyllotoxin and its derivatives, as a potent cytotoxic agent, have been at the center of extensive chemical amendment and pharmacological investigation. Herein, a new series of podophyllotoxin-N-sulfonyl amidine hybrids (4a–4v, 5a–5f) were synthesized by a CuAAC/ring-opening procedure. All the synthesized podophyllotoxins derivatives were evaluated for in vitro cytotoxic activity against a panel of human lung (A-549) cancer cell lines. Different substituents’, or functional groups’ a

APA, Harvard, Vancouver, ISO, and other styles

8

JAYATI, MITRA, and KUMAR MITRA ALOK. "Carbon-13 NMR Chemical Shifts of some Podophyllum Lignans and Analogues." Journal of Indian Chemical Society Vol. 74, Sep 1997 (1997): 692–94. https://doi.org/10.5281/zenodo.5895595.

Full text

Abstract:

Department of Chemistry, University College of Science, Calcutta-700 009 <em>Manuscript received 6 April 1995, revised 15 July 1996, accepted 7 August 1996</em> Carbon-13 nmr chemical shifts of a number of podophyilum lignans, podophyllotoxin, 4'-demethylpodophyllotoxin, podophyllotoxone, desoxypodophyllotoxin and their derivatives have been determined. The derivatives include 1-naphthol, quinone, diol and tetrahydrofuran compounds.

APA, Harvard, Vancouver, ISO, and other styles

9

Zhang, Jing, Ying-Qian Liu, Liu Yang, and Gang Feng. "Podophyllotoxin Derivatives Show Activity against Brontispa Longissima Larvae." Natural Product Communications 5, no. 8 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500820.

Full text

Abstract:

In an attempt to find biorational insecticides, eleven podophyllotoxin analogues were tested for their insecticidal activity against the fifth-instar larvae of Brontispa longissima in vivo for the first time. Among all of the tested compounds, deoxypodophyllotoxin (3) and β-apopicropodophyllin (4) showed more promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia toosendan, and important SAR information has been revealed. Together, these preliminary results may be useful in guiding further modification of podophyllotoxins in the development

APA, Harvard, Vancouver, ISO, and other styles

10

Srivastava, Utkarsha, and Hemant Sood. "Computational Analysis for Regulation of Podophyllotoxin Biosynthesis Pathway in Podophyllum with Potential Substitute Species." Defence Life Science Journal 7, no. 2 (2022): 97–102. http://dx.doi.org/10.14429/dlsj.7.17445.

Full text

Abstract:

Podophyllum species, the source of important secondary metabolite, podophyllotoxin, is over-exploited for production of anti-cancer drugs endangering this genus globally. Lack of complete knowledge on podophyllotoxin biosynthesis is a major drawback in its cultivation and identification for alternative plants. The current study on secoisolariciresinol dehydrogenase, dirigent protein oxidase and pluviatolide synthase identifies their role in regulating podophyllotoxin biosynthesis. The present computational analysis of podophyllotoxin proposes a correlating interconnected network of pathways fo

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "Podophyllotoxin"

1

Macdonald, Dwight I. "Synthesis of podophyllotoxin and analogs." Thesis, University of Ottawa (Canada), 1987. http://hdl.handle.net/10393/5371.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Hammonds, Timothy Robin. "Antiviral effects of podophyllotoxin derivatives." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335849.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Beard, A. "Synthesis of analogues of podophyllotoxin." Thesis, University of Reading, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376237.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Vanderwal, Christopher D. "Attempted enantioselective total synthesis of podophyllotoxin." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ36752.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Pullockaran, Anie Jose. "Synthesis of labelled precursors of podophyllotoxin." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/46060.

Full text

Abstract:

<p>Podophyllotoxin is an aryltetralin lignan and anticancer agent produced by the <i>Podophyllum</i> and some other species and is extracted from Podophyllin in up to 30 percent yield. Little definitive information is available on the biosynthetic pathways to podophyllotoxin. Administering various specifically labelled precursors into intact plants and tissue cultures can give a much improved insight into the lignan biogenesis. The first part of the work has been to the synthesis of two diastereotopically labelled with <sup>2</sup>H at C-4. Desoxypodophyllotoxin is the penultimate interme

APA, Harvard, Vancouver, ISO, and other styles

6

Neidigh, Kurt Alan. "Studies on the biosynthesis of podophyllotoxin : synthesis of labelled yatein and matairesinol, two potential precursors of podophyllotoxin /." This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-09192009-040255/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Baur, Wendy L. "Study of Podophyllotoxin Biosynthesis in Podophyllum species /." Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-03122009-040904/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Reeve, Maxwell Marco. "Synthetic approaches to prephenate analogues and podophyllotoxin." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/12852.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Oliva, Francisco. "The Anti-cancer Properties of Podophyllotoxin Analogues." Youngstown State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1579197212456721.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Garden, Hermann Jörn. "Biotechnological production of podophyllotoxin by linum album suspension cultures." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970145098.

Full text

APA, Harvard, Vancouver, ISO, and other styles

More sources

Books on the topic "Podophyllotoxin"

1

Haldimann, David. Über den Nachweis und die Produktion von Sekundärmetobaoliten: Insbesondere bon Podophyllotoxin in Zellkulturen von Podophyllum sowie in Wurzelkulturen von Linum flavus. 1989.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Podophyllotoxin"

1

Pang, Xiao-Cong, Li Zhang, and Guan-Hua Du. "Podophyllotoxin." In Natural Small Molecule Drugs from Plants. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8022-7_90.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Stähelin, H., and A. von Wartburg. "From podophyllotoxin glucoside to etoposide." In Progress in Drug Research. Birkhäuser Basel, 1989. http://dx.doi.org/10.1007/978-3-0348-9146-2_8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Lohmann, K. "Therapie kondylomatöser Erkrankungen — Podophyllin vs. Podophyllotoxin —." In Operative Dermatologie. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79468-1_20.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Van Uden, W., and N. Pras. "Callitris spp. (Cypress Pine): In Vivo and In Vitro Accumulation of Podophyllotoxin and Other Secondary Metabolites." In Biotechnology in Agriculture and Forestry. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-58062-8_7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Mikac, Sara, Lucija Markulin, Samantha Drouet, et al. "Bioproduction of Anticancer Podophyllotoxin and Related Aryltretralin-Lignans in Hairy Root Cultures of Linum flavum L." In Reference Series in Phytochemistry. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-30185-9_20.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Mikac, Sara, Lucija Markulin, Samantha Drouet, et al. "Bioproduction of Anticancer Podophyllotoxin and Related Aryltretralin-Lignans in Hairy Root Cultures of Linum Flavum L." In Reference Series in Phytochemistry. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-11253-0_20-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Sasheva, Pavlina, and Iliana Ionkova. "Small Cells for Big Ideas: The Cytotoxic Podophyllotoxin and the Long Journey in Discovering Its Biosynthetic Pathway." In Biotechnology and Production of Anti-Cancer Compounds. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53880-8_8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Kumar, Vinod, Vikram Sahai, and V. S. Bisaria. "Effect of Piriformospora indica on Enhanced Biosynthesis of Anticancer Drug, Podophyllotoxin, in Plant Cell Cultures of Linum album." In Soil Biology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-33802-1_7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Fujii, Yasuo. "Podophyllum spp.: In Vitro Regeneration and the Production of Podophyllotoxins." In Biotechnology in Agriculture and Forestry. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84071-5_22.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Lata, Hemant, Cassia S. Mizuno, and Rita M. Moraes. "The Role of Biotechnology in the Production of the Anticancer Compound Podophyllotox." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-287-2_31.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Podophyllotoxin"

1

Kumar, Ajay, Eric Miranda Valentin, and Miguel Otero. "Abstract 4285: Immunomodulatory activity of aza-podophyllotoxin derivatives." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4285.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Chen, Zai-Xin, Wei-Yong Ma, and Chun-Nian Zhang. "Stereoselective Synthesis of New Podophyllotoxin Derivative: 4-cyano-4-deoxy-4-demethylepipodophyllotoxin." In The 3rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1999. http://dx.doi.org/10.3390/ecsoc-3-01772.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Santana, Michael Concepcion, Ajay Kumar, Vineet Kumar, Antonio E. Alegria, and Sanjay V. Malhotra. "Abstract 1631: Structural activity relationship studies of aza-podophyllotoxin derivatives on breast cancer cell line." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-1631.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Flamandita, Darin, Kenny Lischer, Diah Kartika Pratami, Reza Aditama, and Muhamad Sahlan. "Molecular docking analysis of podophyllotoxin derivatives in Sulawesi propolis as potent inhibitors of protein kinases." In INTERNATIONAL CONFERENCE ON EMERGING APPLICATIONS IN MATERIAL SCIENCE AND TECHNOLOGY: ICEAMST 2020. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0002596.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Danaeipour, Zahra, Ghasemali Garoosi, Masoud Tohidfar, Mohammad Reza Bakhtiarizadeh, and Mohammad Hossein Mirjalili. "Podophyllotoxin Content Analysis of Linum album Kotschy ex Boiss. Subjected to Short-Term Potassium Deficiency Stress." In International Electronic Conference on Medicinal Chemistry. MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13420.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Choi, Jae Yeon, Sang-Gu Hwang, Hong-Duck Um та Jong Kuk Park. "Abstract 3343: Podophyllotoxin acetate (PA) enhancing γ-ionizing radiation-induced apoptosis via the ROS/p38/caspase pathway". У Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3343.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Gilson, Richard, Kate Bennett, Frank Sandmann, et al. "O06.4 Efficacy and cost-effectiveness of qHPV vaccine with imiquimod or podophyllotoxin for patients with anogenital warts (HIPvac)." In Abstracts for the STI & HIV World Congress (Joint Meeting of the 23rd ISSTDR and 20th IUSTI), July 14–17, 2019, Vancouver, Canada. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/sextrans-2019-sti.137.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Chen, Jia-Yang, Wen-Shan Li, and Yi-Ching Wang. "Abstract C219: Inhibition of cancer cell growth and migration of podophyllotoxin derivative in cancer cells and its mechanistic study." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-c219.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Young, Rebecca S., Si Liao, Steve N. Slilaty, and Susannah Gal. "Abstract 1758: A podophyllotoxin derivative, Adva-27a, is more potent at killing multi-drug resistant breast cancer cells than etoposide." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1758.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Cho, Jeong Hyun, Wan Gi Hong, Sang-Gu Hwang, Hong-Duck Um, and Jong Kuk Park. "Abstract 1241: Podophyllotoxin acetate (PA) as an anti-cancer drug candidate regulates various malignancy traits of non-small cell lung cancer." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1241.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!