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Relevant bibliographies by topics / Polygodial

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Academic literature on the topic 'Polygodial'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Polygodial"

1

Lunde, Christopher S., and Isao Kubo. "Effect of Polygodial on the Mitochondrial ATPase of Saccharomyces cerevisiae." Antimicrobial Agents and Chemotherapy 44, no. 7 (2000): 1943–53. http://dx.doi.org/10.1128/aac.44.7.1943-1953.2000.

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ABSTRACT The fungicidal mechanism of a naturally occurring sesquiterpene dialdehyde, polygodial, was investigated in Saccharomyces cerevisiae. In an acidification assay, polygodial completely suppressed the glucose-induced decrease in external pH at 3.13 μg/ml, the same as the fungicidal concentration. Acidification occurs primarily through the proton-pumping action of the plasma membrane ATPase, Pma1p. Surprisingly, this ATPase was not directly inhibited by polygodial. In contrast, the two other membrane-bound ATPases in yeast were found to be susceptible to the compound. The mitochondrial AT

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2

Kipanga, Purity N., Liesbeth Demuyser, Johannes Vrijdag, et al. "Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae." International Journal of Molecular Sciences 22, no. 11 (2021): 5756. http://dx.doi.org/10.3390/ijms22115756.

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Polygodial is a “hot” peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of Saccharomyces cerevisiae, a genome-wide mutant screen was performed to shed more light on polygodial’s antifungal mechanism of action. We identified 66 deletion strains that were hypersensitive and 47 that were highly resistant to polygodial treatment. Among the hypersensitive strains, an enrichment was found for genes required for vacuolar acidification, amino acid biosynthesis, nucleosome mobilization, the transcr

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3

Marín, Víctor, Cecilia Villegas, Ayorinde Víctor Ogundele, et al. "Inhibitory Potential of the Drimane Sesquiterpenoids Isotadeonal and Polygodial in the NF-kB Pathway." Molecules 30, no. 7 (2025): 1555. https://doi.org/10.3390/molecules30071555.

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Inflammation contributes to the onset and development of many diseases, including neurodegenerative diseases, caused by the activation of microglia, leading to neurological deterioration. Nuclear factor-κB (NF-κB) is one of the most relevant pathways for identifying anti-inflammatory molecules. In this study, polygodial and isotadeonal, two drimane sesquiterpene dialdehydes, were isolated from Drimys winteri, a medicinal tree of the Mapuche people in Chile. Isotadeonal, or epi-polygodial, was obtained from polygodial by epimerization in basic media (60% yield, Na2CO3, r/t, 24 h). Both sesquite

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4

Kutney, James P., Yong-Huang Chen, and Steven J. Rettig. "The chemistry of thujone. XVIII Homothujone and its derivatives." Canadian Journal of Chemistry 74, no. 5 (1996): 666–76. http://dx.doi.org/10.1139/v96-072.

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The monoterpene thujone (1) is ring expanded regioselectively to provide homothujone (4) in order to explore its potential as a chiral starting material. Stereoselective Robinson annulation of homothujone provides an enone intermediate (5), further derivatization of which was undertaken to furnish functionalized naphthalenones useful for synthesis of the antifeedant (−)-polygodial and the ambergris fragrance (−)-Ambrox®. Key words: thujone, homothujone, synthesis, naphthalenones, polygodial, Ambrox.

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5

Kubo, Isao, Ken'ichi Fujita, and Sang Hwa Lee. "Antifungal Mechanism of Polygodial." Journal of Agricultural and Food Chemistry 49, no. 3 (2001): 1607–11. http://dx.doi.org/10.1021/jf000136g.

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6

Kubo, Isao, and Makoto Taniguchi. "Polygodial, an Antifungal Potentiator." Journal of Natural Products 51, no. 1 (1988): 22–29. http://dx.doi.org/10.1021/np50055a002.

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7

Kubo, Isao, Ken-ichi Fujita, Sang Hwa Lee, and Tae Joung Ha. "Antibacterial activity of polygodial." Phytotherapy Research 19, no. 12 (2005): 1013–17. http://dx.doi.org/10.1002/ptr.1777.

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8

Kutney, James P., Krystyna Piotrowska, Yong-Huang Chen, Kwok-Ping Norman Cheng, Zhenyong Gao, and Steven J. Rettig. "The chemistry of thujone. XV. A versatile route to antifeedants of the polygodial family." Canadian Journal of Chemistry 68, no. 10 (1990): 1698–708. http://dx.doi.org/10.1139/v90-264.

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Utilizing thujone-derived intermediates, efficient routes to the natural polygodial family of antifeedants as well as novel analogues within this family are described. One of the key features of this study involves the insertion of an oxygen function into a tertiary carbon center adjacent to a cyclopropane ring system thus providing convenient intermediates for subsequent elaboration. An interesting ring expansion of five-membered to six-membered ring systems by means of tri-n-butyltin hydride is also described. Keywords: antifeedants, polygodial, thujone.

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9

Asakawa, Yoshinori, Masako Sekita, and Toshihiro Hashimoto. "Biotransformation of Bicyclic Sesqui- and Diterpene 1,2-dials and Their Derivatives by the Fungus, Aspergillus niger." Natural Product Communications 13, no. 8 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300802.

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Microbial biotransformation of naturally occurring pungent sesquiterpene 1,2-dials, polygodial and cinnamodial, and a diterpene 1,2-dial, sacculatal as well as their tetrahydro derivatives was carried out by using Aspergillus niger. The pungent polygodial and sacculatal are toxic against A. niger not to produce any metabolites while A. niger biotransformed cinnamodial to the lactonized products in small amount. On the other hands, the dihydroxy derivatives of the former two dialdehydes were bioconverted by the same fungus to give hydroxy-, oxo-, carboxylic- and epoxy-products. The stereostruct

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10

Cahill, Patrick L., Javier Atalah, Andrew I. Selwood, and Jeanne M. Kuhajek. "Metamorphosis of the invasive ascidianCiona savignyi: environmental variables and chemical exposure." PeerJ 4 (February 25, 2016): e1739. http://dx.doi.org/10.7717/peerj.1739.

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In this study, the effects of environmental variables on larval metamorphosis of the solitary ascidianCiona savignyiwere investigated in a laboratory setting. The progression of metamorphic changes were tracked under various temperature, photoperiod, substrate, larval density, and vessel size regimes. Metamorphosis was maximised at 18 °C, 12:12 h subdued light:dark, smooth polystyrene substrate, and 10 larvae mL−1in a twelve-well tissue culture plate. Eliminating the air-water interface by filling culture vessels to capacity further increased the proportion of metamorphosed larvae; 87 ± 5% of

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Book chapters on the topic "Polygodial"

1

Powell, Glen, Jim Hardie, and John A. Pickett. "Effects of the plant-derived antifeedant polygodial on aphid host selection behaviour." In Proceedings of the 8th International Symposium on Insect-Plant Relationships. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-1654-1_62.

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2

Banthorpe, D. V. "Polygonum hydropiper L. (Water Pepper): In Vitro Culture and the Production of the Aphid-Antifeedant Polygodial." In Medicinal and Aromatic Plants IV. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77004-3_18.

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3

Kubo, Isao. "Polygodial and Warburganal, Antifungal Sesquiterpene Dialdehydes and Their Synergists." In The Biology - Chemistry Interface. CRC Press, 1999. http://dx.doi.org/10.1201/9780203909607.ch2.

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Conference papers on the topic "Polygodial"

1

Pillai, Akshita P., Subramanyam Dasari, Bhavani Patel, Souresh Banerjee, Alexander V. Kornienko, and Gnanasekar Munirathinam. "Abstract 4804: Polygodial: A potential sesquiterpene dialdehyde for castration-resistant prostate cancer treatment." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4804.

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