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Journal articles on the topic 'Postoperative analgesic'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Liu, Ling, Guoqing Zhao, Yuchang Dou, et al. "Analgesic effects of perioperative acupuncture methods: A narrative review." Medicine 102, no. 43 (2023): e35759. http://dx.doi.org/10.1097/md.0000000000035759.

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Postoperative pain occurs immediately after surgery. The most common perioperative analgesic methods are nerve block, patient-controlled intravenous analgesia, and patient-controlled epidural analgesia. However, overuse of opioid analgesics can cause many adverse reactions including excessive sedation, respiratory inhibition, postoperative nausea, and vomiting. In recent years, many clinical trials have shown that perioperative acupuncture has unique advantages in patients. Perioperative acupuncture can relieve intraoperative pain, improve postoperative pain management, reduce postoperative na

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Kelleci, Yavuz, Ruslan Abdullayev, Beliz Bilgili, Ayten Saraçoğlu, and Tümay Umuroğlu. "Epidural versus intravenous analgesia for pain control in kidney donors, a retrospective cohort study. Is there a kinship relationship?" Eurasian Journal of Anesthesiology and Intensive Care 1, no. 1 (2024): 1–5. http://dx.doi.org/10.51271/eajaic-0001.

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Aims: Best care must be provided for live kidney donors, including postoperative pain control. Treatment options include iv intermittent analgesics, iv or epidural patient-controlled analgesia (PCA). In this study we aimed to compare these modalities with respect to their analgesic efficacy. Methods: A retrospective analysis of fifty-eight live donor nephrectomy patients operated in a 7-year-period in a university hospital performed. Investigational Review Board approval has been obtained. Data of the patients’ postoperative analgesia methods, degree of kinship with the recipient, postoperativ

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Nandanwankar, Niteen, and Abdullah MF. "EVALUATION OF TRANSVERSUS ABDOMINIS PLANE (TAP) BLOCK WITH INJ.BUPIVACAINE 0.25% FOR POST-OPERATIVE ANALGESIA IN INGUINAL HERNIA REPAIR SURGERY." PERSPECTIVES IN MEDICAL RESEARCH 7, no. 3 (2020): 30–37. http://dx.doi.org/10.47799/pimr.0703.06.

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Background: TransversusAbdominis Plane(TAP)Block is a regional analgesictechnique. It provides postoperative analgesia after lower abdominal surgery. The purpose of our study was to evaluate effectiveness of TAP block to provide effective postoperative analgesia in patients undergoing inguinal hernia repair surgery. Method: Total 60 patients undergoing inguinal hernia surgery were randomized toundergo TAP block with bupivacaine (n = 30) versus normal saline (n = 30)control group. All patients received a standard spinal anaesthesia with standardmonitoring. A TAP block was performed using 20 ml

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Cheung, Chi Wai. "Analgesic Efficacy and Adverse Effects of Meperidine in Managing Postoperative or Labor Pain: A Narrative Review of Randomized Controlled Trials." Pain Physician 2;23, no. 4;2 (2020): 175–201. http://dx.doi.org/10.36076/ppj.2020/23/175.

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Background: Meperidine, a synthetic opioid, has a rapid onset and short duration of action. Mounting evidence has challenged meperidine’s analgesic benefits, and concerns have been raised about its safety profile. Despite recommendations to restrict the prescription of meperidine, the drug remains frequently used. Objectives: The aim of this study was to evaluate the evidence regarding the efficacy and safety of meperidine for acute postoperative and labor pain. Study Design: This was a narrative review of the analgesic efficacy and side effects of meperidine compared to other analgesic drugs

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Majeed, Amer, Noon E. Abdelgadir, Areej A. G. AlFattani, et al. "Evaluation of acute postoperative pain management after living donor nephrectomy during the transition from open access to laparoscopic and minimally invasive robotic surgical approach." Saudi Journal of Anaesthesia 19, no. 1 (2025): 39–44. https://doi.org/10.4103/sja.sja_425_24.

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Background: Living donor nephrectomies (LDN) at our institution transitioned from open access to laparoscopic and, more recently, to a minimally invasive robotic surgical approach between 2019 and 2022. Concurrently, postoperative analgesia transitioned from regional anesthesia to intravenous patient-controlled analgesia (PCA) and eventually to simple analgesics with additional rescue analgesic agents, as needed, in accordance with individual physicians’ preferences. This retrospective study was designed to evaluate the impact of these changes on surgical practice on the analgesic requirements

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Bernadeth, Bernadeth, Ezra Oktaliansah, and Indriasari Indriasari. "Efektivitas Analgesik Pascaoperasi pada Pasien Pediatrik di Ruang Pemulihan Rumah Sakit Dr. Hasan Sadikin Bandung Periode Juni–November 2018." Jurnal Anestesi Perioperatif 7, no. 1 (2019): 68–84. http://dx.doi.org/10.15851/jap.v7n1.15647.

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Nyeri merupakan pengalaman sensorik dan emosional yang tidak menyenangkan. Penyebab utama nyeri akut pada anak adalah prosedur pembedahan, trauma, dan penyakit akut. Penilaian nyeri merupakan bagian penting dari manajemen nyeri. Penelitian ini bertujuan mengetahui efektivitas analgesik pascaoperasi pada pasien pediatrik di ruang pemulihan RSUP Dr. Hasan Sadikin Bandung periode Juni-November 2018. Penelitian menggunakan metode deskriptif observasional prospektif terhadap 471 pasien pediatrik pascaoperasi di ruang pemulihan. Subjek penelitian dikelompokkan berdasar atas jenis operasi yang menyeb

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Tantri, Aida Rosita, Riyadh Firdaus, Hansen Angkasa, Ahmad Pasha Natanegara, and Muhammad A. I. Maulana. "Pre-emptive versus preventive analgesia for postoperative pain: a systematic review and meta-analysis." Universa Medicina 42, no. 2 (2023): 227–39. http://dx.doi.org/10.18051/univmed.2023.v42.227-239.

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BackgroundPostoperative pain is a type of nociceptive pain that originates from tissue damage due to trauma caused by surgery. Pre-emptive analgesia is treatment that starts before surgery, to prevent or reduce the establishment of sensitization of dorsal horn neurons caused by tissue injury, the sensitized neurons being supposed to amplify postoperative pain. Pre-emptive analgesia consists of administering analgesic medication before tissue injury, that is, before the reception, transmission, modulation, and nociception of the aggressive stimulus, aiming to prevent hyperalgesia. This review a

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Li, Xinguo, Caiyan Yang, Hui Yan, Xiaobo Suo, Zong Ma, and Daqing Xu. "Postoperative analgesic effect of dezocine combined with sufentanil: A propensity score matching study." Medicine 104, no. 26 (2025): e43041. https://doi.org/10.1097/md.0000000000043041.

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Postoperative pain can produce a variety of adverse reactions, prolong postoperative recovery time and length of hospital stay and increase medical costs. Postoperative analgesia methods are different; dezocine combined with sufentanil is one such method, but its the efficacy remains uncertain. Therefore, we investigated the clinical efficacy and medical costs of dezocine combined with sufentanil for postoperative analgesia. A retrospective observation and analysis were conducted on all patients admitted to a tertiary hospital in Ningxia Hui Autonomous Region from March 1, 2022 to March 3, 202

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Jipa, Miruna, Sebastian Isac, Artsiom Klimko, et al. "Opioid-Sparing Analgesia Impacts the Perioperative Anesthetic Management in Major Abdominal Surgery." Medicina 58, no. 4 (2022): 487. http://dx.doi.org/10.3390/medicina58040487.

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Background and Objectives: The management of acute postoperative pain (APP) following major abdominal surgery implies various analgetic strategies. Opioids lie at the core of every analgesia protocol, despite their side effect profile. To limit patients’ exposure to opioids, considerable effort has been made to define new opioid-sparing anesthesia techniques relying on multimodal analgesia. Our study aims to investigate the role of adjuvant multimodal analgesic agents, such as ketamine, lidocaine, and epidural analgesia in perioperative pain control, the incidence of postoperative cognitive dy

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Peng, Lihua, Li Ren, Peipei Qin, et al. "Continuous Femoral Nerve Block versus Intravenous Patient Controlled Analgesia for Knee Mobility and Long-Term Pain in Patients Receiving Total Knee Replacement: A Randomized Controlled Trial." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/569107.

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Objectives. To evaluate the comparative analgesia effectiveness and safety of postoperative continuous femoral nerve block (CFNB) with patient controlled intravenous analgesia (PCIA) and their impact on knee function and chronic postoperative pain.Methods. Participants were randomly allocated to receive postoperative continuous femoral nerve block (group CFNB) or intravenous patient controlled analgesia (group PCIA). Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores for knee and incidence of chronic postoperative pain at 3, 6, and 12 months postoperatively were comp

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Taliercio, Salvatore, Brian Sanders, Stratos Achlatis, Yixin Fang, Ryan Branski, and Milan Amin. "Factors Associated With the Use of Postoperative Analgesics in Patients Undergoing Direct Microlaryngoscopy." Annals of Otology, Rhinology & Laryngology 126, no. 5 (2017): 375–81. http://dx.doi.org/10.1177/0003489417693862.

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Objective: Morbidity associated with suspension laryngoscopy has been well documented. However, standard of care with regard to postoperative analgesia has not been described, and anecdotal evidence suggests wide variability with regard to postoperative narcotic and non-narcotic recommendations. We sought to quantify the postoperative course following suspension microlaryngoscopy by relating patient-based and intraoperative measures with analgesic use. Methods: Body mass index (BMI), Friedman tongue position (FTP), and Mallampati scores as well as laryngoscope type, number of attempts required

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Pistorius, Regina, Anna Widder, Marleen Sabisch, et al. "Understanding the Perioperative Perception of Pain in Patients with Crohn’s Disease: Epidural Versus Non-Epidural Analgesia." Journal of Clinical Medicine 14, no. 12 (2025): 4383. https://doi.org/10.3390/jcm14124383.

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Background: Patients with Crohn’s disease (CD) suffer from a relevant burden of abdominal pain and psychological distress that can aggravate postoperatively. While systematic strategies for postoperative pain management are lacking, the potential benefit of perioperative epidural analgesia (EDA) in CD patients is unclear. Methods: All patients receiving an ileocecal resection due to CD at a tertiary hospital were included. The impact of epidural versus non-epidural analgesia on postoperative pain perception was evaluated by analyzing the numeric rating scale (NRS), analgesic consumption, and c

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Waechter, Fábio Luiz, José Artur Sampaio, Rinaldo Danesi Pinto, Mário Reis ÁLvares-Da-Silva, and Luiz Pereira-Lima. "A Comparison between Topical and Infiltrative Bupivacaine and Intravenous Meperidine for Postoperative Analgesia after Inguinal Herniorrhaphy." American Surgeon 67, no. 5 (2001): 447–50. http://dx.doi.org/10.1177/000313480106700513.

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The purpose of the present study is to compare postoperative analgesia offered by the simple instillation of local anesthetic on the surgical wound, its infiltration with the same local anesthetic, and the use of an intravenous opioid. Sixty patients were divided into the three analgesia groups to be studied: instillation of local anesthetic (Group I), injection of local anesthetic (Group II), and intravenous opioid (Group III). The pain was quantified using the visual analogue scale. It was observed that there was better analgesia in Groups I and II during the first 6 hours postoperatively as

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Kurt, Nurettin, Nureddin Yuzkat, Celaleddin Soyalp, and Mehmet Kilic. "Postoperative Analgesic Efficacy Of Ilioinguinal-Iliohypogastric Block In Inguinal Hernia Surgeries: A Prospective Randomized Single-Blind Study." ULUTAS MEDICAL JOURNAL 9, no. 3 (2023): 158. http://dx.doi.org/10.5455/umj.20230813123641.

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Introduction: Ilioinguinal-iliohypogastric (II/IH) nerve block is used for postoperative analgesia in lower abdominal surgeries. We aimed to compare the postoperative analgesic efficacy of ultrasound (US) guided II/IH nerve block, tramadol, and paracetamol in patients scheduled for unilateral inguinal hernia surgery. Materials and Methods: The study population consisted of patients who underwent surgery diagnosed with inguinal hernia. Sixty male cases aged 18-65 years and ASA I-II were included in the study. After spinal anesthesia, those who underwent II/IH nerve block under US guidance for p

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Sucipto, Priskila Wulan, and Marilaeta Cindryani Ra Ratumasa. "The Impact of Ultrasound-Guided Subcostal Transversus Abdominis Plane (SCTAP) Block on Postoperative Pain Relief in a Patient Undergoing Cholecystectomy: A Case Report." Journal of Anesthesiology and Clinical Research 5, no. 1 (2024): 527–30. http://dx.doi.org/10.37275/jacr.v5i1.469.

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Introduction: Handling post-operative pain in cholecystectomy requires several considerations, especially in terms of pain management. Various multimodal analgesia strategies to optimize postoperative pain control include epidural catheter placement, intravenous opioids, and the recently introduced ultrasonography (USG)-guided subcostal transversus abdominis plane (SCTAP) block. This case report aims to describe the postoperative analgesic effectiveness of ultrasound-guided SCTAP block in a patient undergoing open cholecystectomy. Case presentation: A 57 year old female patient with a di

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Afify, Noha, and Khaled Gaballah. "The analgesic efficacy of subcutaneous nalbuphine compared with epidural analgesia in abdominal surgeries: A randomized controlled trial." Revista Chilena de Anestesia 52, no. 6 (2023): 604–10. http://dx.doi.org/10.25237/revchilanestv52n6-08.

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Background: Analgesia represents a cornerstone for the perioperative management of patients undergoing open abdominal surgery. Epidural analgesia (EPA) is a standard method for pain control in 50%-60% of major abdominal surgeries. Nalbuphine -a synthetic opioid agonist/ antagonist- has equianalgesic properties to morphine but without the undesirable side effects of the pure agonists. Objective: We compared the perioperative analgesic efficacy of subcutaneous nalbuphine and epidural analgesia in abdominal surgeries. Methods: 130 adult patients of both sexes with American Society of Anesthesiolo

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Lavand’homme, Patricia, Marc De Kock, and Hilde Waterloos. "Intraoperative Epidural Analgesia Combined with Ketamine Provides Effective Preventive Analgesia in Patients Undergoing Major Digestive Surgery." Anesthesiology 103, no. 4 (2005): 813–20. http://dx.doi.org/10.1097/00000542-200510000-00020.

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Background As a broader definition of preemptive analgesia, preventive analgesia aims to prevent the sensitization of central nervous system, hence the development of pathologic pain after tissular injury. To demonstrate benefits from preventive treatment, objective measurement of postoperative pain such as wound hyperalgesia and persistent pain should be evaluated. The current study assessed the role and timing of epidural analgesia in this context. Methods In a randomized, double-blinded trial, 85 patients scheduled to undergo neoplastic colonic resection were included. All the patients rece

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Das, Nabanita, Usha Shukla, Dheer Singh, and Urvashi Yadav. "Comparison of analgesic efficacy between TAP block and local site infiltration post operatively in caesarean section." International Journal of Research in Medical Sciences 6, no. 4 (2018): 1407. http://dx.doi.org/10.18203/2320-6012.ijrms20181305.

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Background: Patients undergoing caesarean section need to be alert, comfortable and mobile in order to take care of their babies, for which they must be pain free in post operative period. The aim of present study is to compare the analgesic efficacy of TAP block with local anaesthetic infiltration specifically in LSCS patients in reducing patient pain postoperatively, as well as to decrease the analgesic requirements.Methods: The study population consisted of 60 patients posted for elective and emergency caesarean section. They were blindly divided into two groups of 30 patients each. Group T

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Kelesi, Martha, and Maria Bourazani. "The postoperative pain management in mastectomy and immediate breast reconstruction with implants." Rostrum of Asclepius 17, no. 3 (2018): 166–80. https://doi.org/10.5281/zenodo.1302443.

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<strong>ABSTRACT</strong> <strong>Introduction:</strong> Most women choose breast reconstruction at the same time as mastectomy. The most common method of breast reconstruction is with tissue expanders (implementation). The relief from the postoperative pain of mastectomy and reconstruction is of major importance. Not only because post-operative pain can become chronic neuropathic, but also because the post-operative immune suppression it exposes the woman with breast cancer to the risk of metastases. <strong>Aim:</strong> To investigate the methods of postoperative pain management in mas

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Varma, Brejesh Ravi, Shabeel Aboobacker, Ashitha Koyaparambath, and Neethu Vijayakumar Sheela. "Comparative Study of Bupivacaine-Dexmeditomidine and Bupivacaine-Fentanyl with Bupivacaine Plain as Local Infiltration for Postoperative Analgesia After Abdominal Hysterectomy Under Subarachnoid Block." NATIONAL BOARD OF EXAMINATIONS JOURNAL OF MEDICAL SCIENCES 3, no. 4 (2025): 442–51. https://doi.org/10.61770/nbejms.2025.v03.i04.007.

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Introduction: Abdominal hysterectomy is a common surgical procedure associated with significant postoperative pain. Effective pain management is crucial to enhance recovery and reduce opioid dependency. Multimodal analgesia, including local wound infiltration with adjuvants, has been explored to optimize pain control. This study compares the efficacy of bupivacaine alone, bupivacaine with fentanyl, and bupivacaine with dexmedetomidine for postoperative analgesia in patients undergoing abdominal hysterectomy. Materials and Methods: This hospital-based observational study was conducted at MES Me

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Patel, Himani. "Abstract No.: ABS1074 : Evaluation of efficacy of superficial cervical plexus block for surgeries in head and neck region: A comparative randomised control study." Indian Journal of Anaesthesia 66, Suppl 1 (2022): S61—S62. http://dx.doi.org/10.4103/0019-5049.340707.

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Background and Aims: Superficial cervical plexus block can provide analgesia in head and neck surgeries. This study aimed to evaluate analgesic efficacy of superficial cervical plexus block (SCPB) in various head and neck surgeries, with the primary objectives of assessing time to first rescue analgesic, total dose of rescue analgesics in 24 hours, intraoperative analgesic requirement and associated perioperative complications. Methods: Sixty patients of American Society of Anesthesiologists physical class II,III (30 patients in each group) were included. Group A received general anaesthesia(G

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Abdallah, Faraj W., Nasir Hussain, Tristan Weaver, and Richard Brull. "Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis." Regional Anesthesia & Pain Medicine 45, no. 7 (2020): 509–19. http://dx.doi.org/10.1136/rapm-2020-101340.

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BackgroundEvidence regarding the role of cannabinoids in managing acute postoperative pain is conflicting. The purpose of this systematic review and meta-analysis was to determine the analgesic efficacy of perioperative cannabinoid compounds for acute pain management after surgery.MethodsOriginal research articles evaluating the addition of cannabinoids to standard opioid-based systemic analgesia (Control) in the postoperative period were sought. Our primary outcomes were cumulative oral morphine equivalent consumption and rest pain severity at 24 hours postoperatively. We also assessed analge

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BRĂDIŞ, Adriana Alexandra, Adrian Daniel TULIN, Erick NESTIANU, and Ioana Anca BĂDĂRĂU. "Acute postoperative pain." Romanian Journal of Medical Practice 11, no. 3 (2016): 231–33. http://dx.doi.org/10.37897/rjmp.2016.3.2.

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Acute postoperative pain is a personal unpleasant sensory and emotional experience with negative physiological and psychological effects. Severe acute pain may increase postoperative morbidity and mortality and is a risk factor for chronic pain incidence. We evaluate pain intensity using pain scales. Pain management includes preventive analgesia who interacts and modulates central sensitization response and multimodal analgesia which uses two or more different analgesic mechanisms agents for a superior analgesic effect. Effective pain management provide early postoperative recovery and decreas

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Kaynak, Ali, Elif Doğan Bakı, Özal Özcan, Bilge Banu Taşdemir Mecit, Bilal Atilla Bezen, and Kamil Taşkapılı. "Investigating the Effect of Pericapsular Nerve Group Block on Postoperative Analgesia in Hip Surgery." Journal of Contemporary Medicine 15, no. 2 (2025): 67–73. https://doi.org/10.16899/jcm.1602974.

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Purpose: With increasing numbers of patients undergoing hip surgery, postoperative analgesia planning for patients also becomes more important. Post-hip surgery pain is categorized as acute and severe, and its effective treatment is paramount. Our study investigates the effectiveness of Pericapsular Nerve Group (PENG) block in postoperative analgesia, the amount of opioid used, and the presence of postoperative nausea and vomiting in hip surgeries in a multimodal analgesia context. Materials and Method: This is a prospective study that includes 102 patients in total, undergoing elective hip su

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Pulkina, O. N., V. P. Ivanov, V. I. Gurskaya, and E. V. Parshin. "Infiltrative analgesia of the skin flap in children with craniosynostosis after reconstructive surgery on skull bones." Messenger of ANESTHESIOLOGY AND RESUSCITATION 16, no. 6 (2020): 37–45. http://dx.doi.org/10.21292/2078-5658-2019-16-6-37-45.

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The objective of the study is to evaluate the effectiveness of analgesia by infiltration of the skin flap with local anesthetic in children with craniosynostosis after reconstructive surgery.Materials and subjects. 50 children with craniosynostosis, who underwent reconstructive surgery on skull bones, were divided into two groups based on the method of postoperative anesthesia: in Group 1(experimental), the infiltration of the skin flap was used within multimodal anesthesia, while in Group 2, it was standard parenteral use of analgesic drugs. In the postoperative period, pain severity was asse

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Yadav, Indresh, Rashmi Thakur, Anisha Nagaria, and Pratibha Jain Shah. "Comparison of dexmedetomidine and clonidine as an adjuvant to levobupivacaine in transversus abdominis plane (TAP) block for postoperative analgesia following inguinal hernia repair." Indian Journal of Clinical Anaesthesia 10, no. 2 (2023): 163–67. http://dx.doi.org/10.18231/j.ijca.2023.032.

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Postoperative analgesia for inguinal hernia procedures can be provided safely and effectively with USG guided TAP blocks. In the TAP block following inguinal hernia repair, we compared the analgesic effectiveness of dexmedetomidine and clonidine.: Seventy four patients undergoing inguinal hernia repair under spinal anesthesia were randomly divided in to Group LD (n=37) and Group LC (n=37). Patients in Group LD received a unilateral USG-guided TAP block with 0.5% levobupivacaine 18ml and dexmedetomidine 1 μg/kg in NS to make a total 20ml at the conclusion of surgery after regression of sensory

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Fawzy, Asmaa, Omar A. Aleem, Ayman A. Rayan, and Alaaeldin A. Aiad. "Pre-emptive ultrasound-guided transversus abdominis plane block in open appendicectomy." Research and Opinion in Anesthesia & Intensive Care 9, no. 4 (2022): 283–87. http://dx.doi.org/10.4103/roaic.roaic_69_19.

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Background Transversus abdominis plane (TAP) block is a newly effective peripheral block which involving mainly the nerves of the anterior abdominal wall in lower abdominal surgery. The present study aimed to evaluate the postoperative analgesic efficacy of right-sided ultrasound guided TAP block by using 20 millimeters of bupivacaine 0.25% in patients undergoing open appendicectomy. Patients and methods After taking informed consent, fifty patients (ASA I and II) undergoing open appendicectomy were randomized into 2 groups (25 each). After induction of general anesthesia; Group B received rig

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Klukowski, Mateusz, Rafał Kowalczyk, Grzegorz Górniewski, Paweł Łęgosz, Marek Janiak, and Janusz Trzebicki. "Iliac Fascia Compartment Block and Analgesic Consumption in Patients Operated on for Hip Fracture." Ortopedia Traumatologia Rehabilitacja 19, no. 5 (2017): 0. http://dx.doi.org/10.5604/01.3001.0010.5825.

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Background. Fractures of the proximal femur in elderly patients are a challenge for orthopedics, anesthesiology and geriatrics. Early mobilization reduces postoperative mortality among these patients. Effective analgesia is necessary to achieve this goal. Material and methods. A retrospective analysis of perioperative medical records of 78. patients undergoing surgical treatment of proximal femur fractures was performed. Group 1 (n=35)consisted of patients who were treated with pharmacologic analgesia only (systemic analgesics) and Group 2 (n=43) involved patients who received a preoperati

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TNAS, Njatomalala, Razafindrafara M., Rajaonera A.T, Rakotondrainibe A., and Samison L.H. "MULTIMODAL POSTOPERATIVE ANALGESIA: COMBINATIONS OF ANALGESICS AFTER ABDOMINAL SURGERY AT CHU- JRA ANTANANARIVO." International Journal of Advanced Research 12, no. 01 (2024): 1238–48. http://dx.doi.org/10.21474/ijar01/18242.

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Introduction :Intense to severe postoperative pain persists despite routine postoperative analgesia. The objective of the study was to determine a type of analgesic combination proposed in the multimodal technique to properly manage postoperative pain after abdominal surgery by laparotomy. Method : A single-center prospective observational study over a period of six months was conducted. Pain scores during the first six hours were assessed during the patients follow-up period. Comparison and correlation tests were used for data analysis (XLSTAT Â® v18). Results : The study included 40 patients

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Brajkovic, Denis, Vladimir Biocanin, Marija Milic, Milan Vucetic, Renata Petrovic, and Bozidar Brkovic. "Quality of analgesia after lower third molar surgery: A randomised, double-blind study of levobupivacaine, bupivacaine and lidocaine with epinephrine." Vojnosanitetski pregled 72, no. 1 (2015): 50–56. http://dx.doi.org/10.2298/vsp1501050b.

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Background/Aim. Surgical extraction of lower third molars is followed by mild or severe postoperative pain which peaks at maximal intensity in the first 12 hours and has a significant impact on a patient?s postoperative quality of life. The use of long-acting local anaesthetics is a promising strategy to improve postoperative analgesia. The aim of the present study was to investigate analgesic parameters and patient satisfaction after using 0.5% levobupivacaine (Lbup), 0.5% bupivacaine (Bup) and 2% lidocaine with epinephrine 1:80,000 (Lid + Epi) for an inferior alveolar nerve block following l

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Qin, Yongyi, Yujiao Yang, Sulan Qin, and Zhaohui Xiong. "Regional nerve block in postoperative analgesia after cesarean section: A narrative review." Medicine 103, no. 52 (2024): e41159. https://doi.org/10.1097/md.0000000000041159.

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Of all obstetric operations, cesarean section is one of the most common. The impact of postoperative pain on physical and mental health in women cannot be ignored. Moreover, effective postoperative analgesia is essential in women who have given birth. Traditional systemic analgesic methods (intravenous analgesia, oral analgesics, etc) are often accompanied by adverse reactions that are positively correlated with the drug dosage. Regional nerve block is an analgesic and anesthetic technique that temporarily blocks nerve conduction by injecting local anesthetics around the nerve roots, nerve tru

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Naidu, M. U. R., T. Ramesh Kumar, U. Shobha Jagdishchandra, et al. "Evaluation of Ketorolac, Ibuprofen‐Paracetamol, and Dextropropoxyphene‐Paracetamol in Postoperative Pain." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 14, no. 2 (1994): 173–77. http://dx.doi.org/10.1002/j.1875-9114.1994.tb02804.x.

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Study Objective. To compare the analgesic efficacy of ketorolac, ibuprofen‐paracetamol (acetaminophen), and dextropropoxyphene‐paracetamol in postoperative pain.Design. Randomized, double‐blind, parallel, single‐dose study.Setting. Multicenter, with five centers participating.Patients. One hundred sixty patients with moderate to severe postoperative pain requiring oral analgesics were enrolled. Seventeen patients were excluded from final analysis due to deviation from protocol.Interventions. Ketorolac tromethamine 10 mg, a combination of ibuprofen 400 mg plus paracetamol 325 mg, or a combinati

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Ramzy Youwakiem, Peter Nashaat, Omar Mohamed, Sherif George, Amin Mohammed, and Engy Samy. "A comparative study between dexmedetomidine and dexamethasone as adjuvants to bupivacaine in ultrasound guided interscalene block for arthroscopic shoulder surgery." Anaesthesia, Pain & Intensive Care 28, no. 5 (2024): 850–58. http://dx.doi.org/10.35975/apic.v28i5.2566.

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Background & Objectives: Arthroscopic surgery is a preferred approach for shoulder surgeries due to its documented advantages of early postoperative recovery. However, postoperative pain remains a concern for which different techniques are used. Interscalene block (ISB), using dexmedetomidine (DXM) or dexamethasone (DXA) as adjuvants to local anesthetics (LA), is a common analgesic method. We conducted this comparative study to establish if any one of the adjuvants is better in terms of postoperative analgesia. Methodology: Patients undergoing shoulder arthroscopy were assigned randomly to

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Vadhanan, Prasanna, Iniya Rajendran, and Vinith Kumar. "Preemptive analgesia with tapentadol in inguinal surgery; a randomized controlled trial." Anaesthesia, Pain & Intensive Care 27, no. 3 (2023): 356–59. http://dx.doi.org/10.35975/apic.v27i3.2230.

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Background & Objective: Preemptive analgesia aims at minimizing the development of central sensitization thereby decreasing postoperative pain and analgesic requirements. Various drugs have been used for this purpose. Tapentadol, is a newer centrally acting analgesic which is effective in moderate to severe pain. The aim of this study was to analyze the effect of preoperative oral tapentadol upon postoperative analgesia and analgesic requirements in patients undergoing inguinal hernia surgeries. Methodology: One hundred adult patients undergoing elective unilateral inguinal hernia repair w

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Zulfiqar, Ghazanfar, Muhammad Imran Anwar, Zaigham Jameel, Saqlain Ghazanfar, Muzammil Khan, and Talha Tariq. "Efficacy of Laparoscopic-Guided Transversus Abdominis Plane Block versus Standard Analgesia for Postoperative Pain Control in Laparoscopic Cholecystectomy." Biological and Clinical Sciences Research Journal 6, no. 5 (2025): 233–37. https://doi.org/10.54112/bcsrj.v6i5.1750.

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The management of postoperative pain following laparoscopic cholecystectomy remains a clinical challenge. While systemic analgesics are routinely used, they may be associated with suboptimal relief and adverse effects. The laparoscopic-guided Transversus Abdominis Plane (TAP) block has emerged as a promising regional technique for effective postoperative analgesia. Objectives: To compare the efficacy of laparoscopic-guided TAP block versus standard systemic analgesia for postoperative pain control in patients undergoing laparoscopic cholecystectomy. Methodology: A prospective, randomized contr

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Thenarasu, Vinishdharma, Deepa Gurunathan, and M. P. Santhosh Kumar. "Comparison of Efficacy of Diclofenac and Paracetamol as Preemptive Analgesic Agent." Biomedical and Pharmacology Journal 11, no. 3 (2018): 1699–706. http://dx.doi.org/10.13005/bpj/1539.

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Extraction of teeth has been a common, routine dental procedure done in clinics which may lead to moderate to severe pain postoperatively. Any pain postoperatively may cause a discomfort in particpants and affects their routine lifestyle. Preemptive analgesics plays an important role in reducing postoperative pain and distress associated with painful dental procedures. Nonsteroidal anti-inflammatory drugs are one of the treatment options to be used as pain relief for surgical teeth extraction. Wherelse, another commonly prescribed drug over-the-counter is Paracetamol. The purpose of this study

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Espinós Ramírez, Carles, Gisela Roca Amatria, Pere Castellví Obiols, et al. "Assessing the Experience and Management of Acute Post-Operative Pain from Caesarean Delivery: A Multi-Centre Cohort Study." Journal of Clinical Medicine 14, no. 13 (2025): 4638. https://doi.org/10.3390/jcm14134638.

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Background: Caesarean section is considered one of the surgeries with the highest prevalence of postoperative pain, yet this is often underestimated and undertreated. This study was aimed at evaluating the prevalence and severity of postoperative pain, assessing which analgesic strategy is the most effective and identifying those risk factors associated with poorer analgesic results. Methods: A multi-centre observational study was conducted on 514 women undergoing elective caesarean section. The primary endpoints included postoperative pain severity at rest and with movement at 6 and 24 h. Res

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Dasgupta, Chaitali. "Early Outcomes Following off-Pump Coronary Artery Bypass Surgery under General Anaesthesia with and without High Thoracic Epidural Analgesia: A Comparative Study." Clinical Cardiology and Cardiovascular Interventions 4, no. 13 (2021): 01–07. http://dx.doi.org/10.31579/2641-0419/198.

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Introduction: Reduction of postoperative morbidity by providing optimal pain relief and improving overall quality of care is an important goal of modern anaesthesia practice. The aim of this prospective, randomized, open, controlled study is to investigate the impact of high thoracic epidural analgesia on early clinical outcomes in patients undergoing off-pump coronary artery bypass (OPCAB) surgery. Methodology: After obtaining the institutional ethics committee approval and written informed consent from all patients, 80 patients of either sex, aged 40 – 70 years, scheduled for elective primar

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Vincent, Divya, Aaron Dsouza, Hezil Saldanha, Antony Eapen, and Kishan Shetty. "Post Operative Analgesic Efficacy Of Erector Spinae Plane Block VS Serratus Anterior Plane Block In Patients Undergoing Modified Radical Mastectomy." Sri Lankan Journal of Anaesthesiology 33, no. 02 (2025): 169–77. https://doi.org/10.4038/slja.v33i02.9569.

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Introduction: Postoperative pain relief following modified radical mastectomy is usually achieved with a combination of systemic opioids and non-opioid simple analgesics. Variable efficacy of pain relief and opioid associated side effects are major limitations with significant impact on the quality of postoperative recovery.Objectives: To compare the analgesic efficacy of ultrasound-guided Erector Spinae Plane Block (ESPB) versus Serratus Anterior Plane Block (SAPB) in patients undergoing Modified Radical Mastectomy (MRM) in terms of the efficacy and duration of analgesia and intraoperative an

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Hassanein, Ahmed. "Regional Analgesia for Laparoscopic Cholecystectomy Using Ultrasound-guided Quadratus Lumborum Block or Erector Spinae Block: A Randomized Controlled Trial." Pain Physician Journal 26, no. 3 (2023): E133—E141. http://dx.doi.org/10.36076/ppj.2023.26.e133.

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BACKGROUND: Postoperative pain increases the incidence of venous thrombosis and respiratory complications, prevents early postoperative ambulation, and prolongs hospital stay. Fascial plane injections such as erector spinae plane (ESP) block and quadratus lumborum (QL) blocks are popular methods for postoperative pain control and reducing opioid consumption. OBJECTIVES: We aimed to evaluate the analgesic effects of ultrasound-guided ESP versus QL block during laparoscopic cholecystectomy for the reduction of pain and analgesic consumption. STUDY DESIGN: Prospective, double-blind, single-center

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Jatmiko, Heru Dwi, Chandra Hermawan Manapa, and Polmihotdin Hutagalung. "Postoperative Analgetic Profile in Pediatric Patients at Dr. Kariadi Hospital." JAI (Jurnal Anestesiologi Indonesia) 16, no. 1 (2024): 34–46. http://dx.doi.org/10.14710/jai.v16i1.62112.

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Background: Pain management is pivotal for pediatric patients post-surgery due to its common occurrence and significant impact on well-being. Effective management involves considerations such as surgical type, analgesic selection, and proper pain assessment.Objective: Knowing the profile of postoperative analgesia in pediatric patients at Dr. Kariadi Hospital using pain assessment instruments based on age classification.Method: Employing an observational descriptive approach with a prospective cohort design, the study sampled 172 pediatric patients across varying pain severity levels. Utilizin

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Mohamed, Sahar A. "Dexmedetomidine as an Adjunctive Analgesic with Bupivacaine in Paravertebral Analgesia for Breast Cancer Surgery." Pain Physician 5;17, no. 5;9 (2014): E589—E598. http://dx.doi.org/10.36076/ppj.2014/17/e589.

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Background: There is little systematic research on the efficacy and tolerability of the addition of adjunctive analgesic agents in paravertebral analgesia. The addition of adjunctive analgesics, such as fentanyl and clonidine, to local anesthetics has been shown to enhance the quality and duration of sensory neural blockades, and decrease the dose of local anesthetic and supplemental analgesia. Objectives: Investigation of the safety and the analgesic efficacy of adding 1 µg/kg dexmedetomidine to bupivacaine 0.25% in thoracic paravertebral blocks (PVB) in patients undergoing modified radical m

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Akshat, Shiv, Rashmi Ramachandran, Vimi Rewari, Chandralekha, Anjan Trikha, and Renu Sinha. "Morphine versus Nalbuphine for Open Gynaecological Surgery: A Randomized Controlled Double Blinded Trial." Pain Research and Treatment 2014 (April 14, 2014): 1–6. http://dx.doi.org/10.1155/2014/727952.

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Introduction. Pain is the commonest morbidity after open surgical procedures. The most effective treatment of postoperative pain is opioid therapy. Morphine, the commonly used opioid, is associated with many side effects including respiratory depression, sedation, postoperative nausea vomiting, and pruritus. Nalbuphine, on the other hand, is known to cause less respiratory depression. Thus this study was undertaken to compare the intraoperative and postoperative analgesic efficacy and side effect profile of the two drugs. Methodology. 60 patients undergoing open gynaecological surgery were ran

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Lauretti, Gabriela R., Raquel de Oliveira, Marlene P. Reis, Anita L. Mattos, and Newton L. Pereira. "Transdermal Nitroglycerine Enhances Spinal Sufentanil Postoperative Analgesia following Orthopedic Surgery." Anesthesiology 90, no. 3 (1999): 734–39. http://dx.doi.org/10.1097/00000542-199903000-00015.

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Background Sufentanil is a potent but short-acting spinal analgesic used to manage perioperative pain. This study evaluated the influence of transdermal nitroglycerine on the analgesic action of spinal sufentanil in patients undergoing orthopedic surgery. Methods Fifty-six patients were randomized to one of four groups. Patients were premedicated with 0.05-0.1 mg/kg intravenous midazolam and received 15 mg bupivacaine plus 2 ml of the test drug intrathecally (saline or 10 microg sufentanil). Twenty to 30 min after the spinal puncture, a transdermal patch of either 5 mg nitroglycerin or placebo

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Singh, Ranju, Kavita Yadav, and Pooja Singh. "Efficacy of analgesia using ilioinguinal–iliohypogastric (IIIH) nerve block, transversus abdominis plane (TAP) block and diclofenac after caesarean delivery under spinal anaesthesia: A non-randomised clinical trial." Indian Journal of Anaesthesia 67, no. 7 (2023): 638–43. http://dx.doi.org/10.4103/ija.ija_746_22.

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Background and Aims: Our aim was to assess the efficacy of analgesia using ilioinguinal–iliohypogastric (IIIH) nerve block, transversus abdominis plane (TAP) block and diclofenac after caesarean delivery (CD) under spinal anaesthesia (SA).] Methods: A total of 457 healthy parturients undergoing CD under SA were included in this prospective, observational study. Groups differed in the postoperative analgesic strategies received by the parturient at the end of surgery: group D (n = 148) received intramuscular diclofenac sodium, group I (n = 153) received bilateral IIIH block with bupivacaine plu

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Daniels, Stephen E., and Michael Golf. "Clinical Efficacy and Safety of Tapentadol Immediate Release in the Postoperative Setting." Journal of the American Podiatric Medical Association 102, no. 2 (2012): 139–48. http://dx.doi.org/10.7547/1020139.

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The appropriate treatment for postoperative pain remains a common dilemma for podiatric surgeons and patients undergoing surgery of the foot and ankle. The treatment of moderate to severe acute pain typically relies heavily on the use of opioid analgesics, such as hydrocodone and oxycodone, which are often associated with adverse effects, including nausea and vomiting. These adverse effects may have a negative impact on postoperative outcomes and reduce patient compliance with analgesic therapy. Tapentadol is a novel, centrally acting analgesic with two mechanisms of action—μ-opioid receptor a

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Sharma, Sagun, Pankaj Baral, Parasmani Shah, and Asmita Rayamajhi. "Postoperative Analgesic Effect of Dexamethasone Added To Ropivacaine for Fascia Iliaca Compartment Block Following Femoral Fracture Surgeries." Journal of Nepalgunj Medical College 21, no. 2 (2023): 17–21. http://dx.doi.org/10.3126/jngmc.v21i2.62779.

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Introduction: Pain is associated with higher perioperative morbidity in fracture patients. Fascia iliaca compartment block is a simple, inexpensive, and effective method of analgesia for femoral fracture surgeries. Many adjuvants have been used with local anaesthetics to prolong post-operative analgesia. Aims: To assess the effects of dexamethasone as an adjuvant to fascia iliaca compartment block on prolongation of post-operative analgesia in patients undergoing femoral fracture surgeries. Methods: Seventy patients aged, 18-65 years with American Society of Anaesthesiologist-Physi

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Mahmoud, Atef Mohamed. "The Efficacy of Erector Spinae Plane Block Compared With Intrathecal Morphine in Postoperative Analgesia in Patients Undergoing Lumbar Spine Surgery: A Double-blind Prospective Comparative Study." Pain Physician Journal 26, no. 2 (2023): 149–59. http://dx.doi.org/10.36076/ppj.2023.26.149.

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BACKGROUND: Severe postoperative pain is experienced by most patients who undergo spine surgery. Erector spinae plane block (ESPB) is a successful method for postoperative analgesia and has only minor complications. Intrathecal morphine (ITM) demonstrates high efficacy for analgesia up to 24 hours postsurgery. ESPBs and ITM for postoperative analgesia in lumbar spine surgeries have never been compared in prior studies. OBJECTIVES: This study aimed to compare the efficacy of ESPB and ITM in postoperative analgesia after lumbar spine surgeries. STUDY DESIGN: A double-blind prospective comparativ

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Tang, Rong, Wen-sheng Lu, Hai-lian Zhong, Fang Wu, and Yu-qian Liu. "Comparison of different adjuvant analgesia for paravertebral block in video-assisted thoracoscopic surgery: A double-blind randomized controlled trial." PLOS One 20, no. 5 (2025): e0322589. https://doi.org/10.1371/journal.pone.0322589.

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Background Local anaesthetic adjuvants have been shown to provide better pain relief and extend the duration of analgesia. But little information is available on which adjuvants are more effective in block extension for thoracic paravertebral block (TPVB) during video-assisted thoracoscopic surgery (VATS). This study aimed to compare the analgesic efficacies of different adjuvants with 0.375% ropivacaine in ultrasound-guided TPVB for VATS. Methods A total of 120 patients who underwent VATS at the study hospital in 2022–2023 were recruited and randomly divided into four groups, including the co

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Cheung, Chi-Wai. "Oral Oxycodone for Acute Postoperative Pain: A Review of Clinical Trials." Pain Physician 2, no. 20;2 (2017): sE33—sE52. http://dx.doi.org/10.36076/ppj.2017.se52.

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Background: Opioids are the mainstay of pain management for acute postsurgical pain. Oral oxycodone is an opioid that can provide effective acute postoperative pain relief. Objectives: To evaluate the use of oral oxycodone for acute postoperative pain management. Study Design: This is a narrative review based on published articles searched in PubMed and Medline from 2003 to 2015 on oral oxycodone for acute postoperative pain management. Methods: Clinical trials related to the use of oral oxycodone for acute postoperative pain management were searched via PubMed and Medline from 2003 to 2015. T

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