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Relevant bibliographies by topics / Potassium channel openers

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Academic literature on the topic 'Potassium channel openers'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Potassium channel openers"

1

Hedlund, H. "Potassium channel openers for treatment of bladder hyperactivity." Urologia Journal 63, no. 4 (1996): 445–47. http://dx.doi.org/10.1177/039156039606300406.

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The potassium (K+) channel openers induce hyperpolarization by ATP-sensitive K+ channels. This group of compounds has been demonstrated to effectively relax the human detrusor and reduce bladder hyperactivity in obstructed rats. In patients with overactive bladders, oral administration and intravenous infusion of different K+ channel openers were without significant effect on urodynamic variables. In conscious dogs, a new K+ channel opener was found to increase bladder compliance with reduced micturition frequency. K+ channel openers have an interesting potential for the treatment of bladder h

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2

Ozcan, Cevher, Martin Bienengraeber, Petras P. Dzeja, and Andre Terzic. "Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation." American Journal of Physiology-Heart and Circulatory Physiology 282, no. 2 (2002): H531—H539. http://dx.doi.org/10.1152/ajpheart.00552.2001.

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K+ channel openers have been recently recognized for their ability to protect mitochondria from anoxic injury. Yet the mechanism responsible for mitochondrial preservation under oxidative stress is not fully understood. Here, mitochondria were isolated from rat hearts and subjected to 20-min anoxia, followed by reoxygenation. At reoxygenation, increased generation of reactive oxygen species (ROS) was associated with reduced ADP-stimulated oxygen consumption, blunted ATP production, and disrupted mitochondrial structural integrity coupled with cytochrome c release. The prototype K+ channel open

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3

Seth, Vikas, Mushtaq Ahmad, Prerna Upadhyaya, Monika Sharma, and Vijay Moghe. "Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice." Substance Abuse: Research and Treatment 4 (January 2010): SART.S6211. http://dx.doi.org/10.4137/sart.s6211.

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The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced by using an opioid antagonist, naloxone. Mice were observed for 30 minutes for the withdrawal signs ie, the characteristic jumping, hyperactivity, urination and diarrhea. ATP-dependent potassium (K+ATP) channel modulators were injected intraperitoneally (i.p.) 30 minutes before the naloxone. It was found that a K+ATP channel opener, minoxidil (

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4

Duty, Susan, and Arthur H. Weston. "Potassium Channel Openers." Drugs 40, no. 6 (1990): 785–91. http://dx.doi.org/10.2165/00003495-199040060-00002.

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Lawson, Kim. "Is there a Therapeutic Future for ‘Potassium Channel Openers’?" Clinical Science 91, no. 6 (1996): 651–63. http://dx.doi.org/10.1042/cs0910651.

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1. Potassium channels, which control cell electrical activity, are among the most regulated of all ion channels in biology. Promotion of activity in K+ channels by a wide range of physiological factors tends to stabilize cell function. 2. The discovery of synthetic molecules (e.g. cromakalim) that ‘directly’ open ATP-sensitive K+ channels has led to a new direction in pharmacology. ATP-sensitive K+ channel-opening properties have subsequently been demonstrated in a diverse range of chemical structures (synthetic and endogenous). 3. The existence of so many different subtypes of K+ channels has

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6

Morley, J. "Potassium channel openers and asthma." Clinical Reviews in Allergy 12, no. 1 (1994): 109–20. http://dx.doi.org/10.1007/bf02815513.

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Menasché, Philippe, Egidijus Kevelaitis, Christian Mouas, Christian Grousset, Armand Piwnica, and Gérard Bloch. "Preconditioning with potassium channel openers:." Journal of Thoracic and Cardiovascular Surgery 110, no. 6 (1995): 1606–14. http://dx.doi.org/10.1016/s0022-5223(95)70020-x.

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Atwal, Karnail S., Suzanne Moreland, John R. McCullough, Brian C. O'Reilly, Syed Z. Ahmed, and Diane E. Normandin. "Aryl cyanoguanidine potassium channel openers." Bioorganic & Medicinal Chemistry Letters 2, no. 1 (1992): 83–86. http://dx.doi.org/10.1016/s0960-894x(00)80661-7.

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Atwal, Karnail S., Suzanne Moreland, John R. McCullough, Syed Z. Ahmed, and Diane E. Normandin. "Benzopyranyl-cyanoguanidine potassium channel openers." Bioorganic & Medicinal Chemistry Letters 2, no. 1 (1992): 87–90. http://dx.doi.org/10.1016/s0960-894x(00)80662-9.

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Frank, C. A., J. M. Forst, T. Grant, et al. "Dihydropyridine KATP potassium channel openers." Bioorganic & Medicinal Chemistry Letters 3, no. 12 (1993): 2725–26. http://dx.doi.org/10.1016/s0960-894x(01)80751-4.

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Dissertations / Theses on the topic "Potassium channel openers"

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Neill, Colin Gardner. "Synthesis of pyridothiadiazine dioxides as potential potassium ion channel openers." Thesis, Heriot-Watt University, 1995. http://hdl.handle.net/10399/1347.

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Kirby, Robert William. "Investigation of the pharmacophore of BK[ca] potassium channel openers." Thesis, Sheffield Hallam University, 2008. http://shura.shu.ac.uk/19920/.

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Large conductance voltage-activated calcium-sensitive potassium channels (BK[ca]) are fundamental in the control of cellular excitability which is critical in the regulation of many physiological processes. Agents that activate the channel (openers) have been proposed to be potential therapeutics for a number of un-met clinical conditions. Several heterogeneous classes of compounds have been described as BK[ca] channel openers and preliminary pharmacophore data has arisen for synthetic molecules based on the structure of benzimidazolones. The project aimed to explore a series of novel compound

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Zhang, Hailin. "ATP-sensitive potassium channels and their modulation by nucleotides and potassium channel openers in vascular smooth muscle cells." Thesis, St George's, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309744.

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Bailey, Elizabeth Helen. "An investigation into the combination of nifedipine with potassium channel openers as potential tocolytic therapy for preterm labour, and a novel potassium channel blocker as potential therapy for post-partum haemorrhage." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/78668/.

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Background Preterm labour and post-partum haemorrhage are leading causes of pregnancy morbidity and mortality. Previous work identified potassium channels expressed in myometrium and hypothesized modulation of channels with greater expression in MSMC than VSMC will influence contractility and avoid cardiovascular effects. By combining calcium channel blockers with potassium channel openers an enhanced tocolytic effect is anticipated. VU590 inhibits Kir 7.1 and it was hypothesised would elicit a contractile effect with therapeutic potential for post-partum haemorrhage. Aim To determine the effe

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Amberg, Gregory C. "A-type potassium currents in gastrointestinal smooth muscle /." abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3060369.

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Tichenor, Jennifer Noel. "Stretch-activated potassium channels in human myometrium and aspects of cGMP signaling." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3316375.

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Hagen, Brian M. "Regulation of calcium-activated potassium channels by localized calcium transients in murine colon." abstract and full text PDF (free order & download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3209955.

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Sigal, Yaron M. "Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3339204.

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Ryan, Devon P. "Characterization of a novel inwardly rectifying potassium channel (Kir2.6) and its role in thyrotoxic hypokalemic periodic paralysis." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3398884.

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Abu, Baker Salah. "Molecular and functional identification of the two-pore K+ channels in bladder smooth muscle." abstract and full text PDF (UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3320570.

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Books on the topic "Potassium channel openers"

1

Isaac, Lynne Mari. Studies of potassium channel inhibitors and openers acting on airways smooth muscle. University of Manchester, 1995.

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Book chapters on the topic "Potassium channel openers"

1

Fozard, John R., and Paul W. Manley. "Potassium Channel Openers." In New Drugs for Asthma, Allergy and COPD. KARGER, 2001. http://dx.doi.org/10.1159/000062131.

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Perrault, Louis P., and Philippe Menasché. "Potassium Channel Openers and Cardiac Surgery." In Developments in Cardiovascular Medicine. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4419-8736-5_18.

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Grover, Gary J. "Therapeutic Potential of ATP-Sensitive K+ Channel Openers in Cardiac Ischemia." In Potassium Channels in Cardiovascular Biology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1303-2_39.

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Leonetti, Gastone. "Potassium Channel Openers in Therapy: Current Use and Perspective in Hypertension." In Pharmacological Control of Calcium and Potassium Homeostasis. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0117-2_29.

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Raeburn, David, and Jan-Anders Karlsson. "Potassium channel openers: Airway pharmacology and clinical possibilities in asthma." In Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Birkhäuser Basel, 1991. http://dx.doi.org/10.1007/978-3-0348-7139-6_4.

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Marzilli, Mario, and Gianmario Sambuceti. "Potassium Channel Openers in Therapy, Current Uses, and Perspectives: Cardiac Ischemia and Angina." In Pharmacological Control of Calcium and Potassium Homeostasis. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0117-2_30.

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Arakawa, Naoshi, Motoyuki Nakamura, Ken-ichi Fukami, and Katsuhiko Hiramori. "Clinical Application of Ischemic Preconditioning by ATP-Sensitive Potassium Channel Openers." In Developments in Cardiovascular Medicine. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4419-8736-5_17.

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Saito, Satoshi, Tsuneo Mizumura, Tadateru Takayama, et al. "Anti-ischemic Effects of the ATP-sensitive Potassium Channel Opener During Coronary Angioplasty." In Developments in Cardiovascular Medicine. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4419-8736-5_19.

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9

Empfield, James R., and Keith Russell. "Chapter 9. Potassium Channel Openers." In Annual Reports in Medicinal Chemistry. Elsevier, 1995. http://dx.doi.org/10.1016/s0065-7743(08)60922-7.

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Mukherjee, Krittika, Vivek Panwar, Deepak Kumar Jindal, et al. "Chromene Derivatives as Potassium Channel Openers or Inhibitors." In The Role of Chromenes in Drug Discovery and Development. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815124330123010014.

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This overview depicts the voltage-regulated potassium channel, which is found in the CNS, and the emerging therapeutic applications of potassium channel modulators. It also discusses the recent developments in our understanding of the mechanisms, that control the activity of a series of channels, that are selective for potassium ions. It has been long recognized that the excitability of cells is mediated by proteins, which can modulate the ability of potassium ions to travel across the cell membrane. Going back ten years, it has become increasingly clear that, potassium ion channels represent

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Conference papers on the topic "Potassium channel openers"

1

Thomson, L. D. J., S. A. Landry, J. Collet, et al. "The Effect of Selective Potassium Channel Openers on Loop Gain and Obstructive Sleep Apnoea Severity: A Proof-of-Concept Randomised Controlled Trial Using Flupirtine." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4914.

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Fang Shen, Li-ping Wu, Yuan Lu, Hua-wei Liang, I. C. Bruce, and Qiang Xia. "Mitochondrial Permeability Transition Dynamics: An Indicator of Mitochondrial Potassium Channel Opener." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1616201.

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Vang, Alexander, Anlong Li, and Gaurav Choudhary. "Effect Of Large Conductance Calcium-Activated Potassium (BK) Channel Opener, NS1619, On Normoxic And Hypoxic Pulmonary Vasculature." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4833.

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