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1

Maiuri, Francesco. Primary lymphomas of the central nervous system. Editoriale BIOS, 1988.

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2

Diaz, Roberto Jose, Gregory W. Basil, and Ricardo J. Komotar. Primary CNS Lymphoma. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0008.

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Central nervous system (CNS) lymphoma must be considered in the differential diagnosis of any immunocompromised patient with a solid brain lesion. In such patients, diagnosis can be made via a careful review of important signs, symptoms, and classic radiologic findings. While there is no single physical exam finding classic for lymphoma, the clinician must carefully evaluate patients for the presence or absence of findings that may suggest an alternative diagnosis. Such findings include the stigmata of endocarditis, symptoms suggestive of pneumonia, or additional non-CNS mass lesions. Addition
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3

Batchelor, Tracy T., Oussama Abla, Zhong-ping Chen, Dennis C. Shrieve, and Samar Issa. Tumours of the haematopoietic system. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0013.

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‘Tumours of the haematopoietic system’ examines the epidemiology, the pathogenesis, and the clinical features of adult and childhood primary central nervous system lymphomas (PCNSLs), extranodal forms of non-Hodgkin lymphoma, as well as the histiocytoses included in the World Health Organization (WHO) classification of central nervous system (CNS) tumours. It reviews these features in the most common PCNSL, primary central nervous system diffuse large B-cell lymphoma, as well as the other rare histopathological PCNSL variants including lymphomatoid granulomatosis, T-cell lymphoma, anaplastic l
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4

DeAngelis, Lisa M. Primary Central Nervous System Lymphoma. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0133.

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The lymphoid nature of PCNSL was established unequivocally by modern immunohistochemical techniques. PCNSL has been associated with a variety of congenital (Wiskott-Aldrich syndrome, ataxia-telangiectasia) and acquired (human immunodeficiency virus [HIV], renal transplant recipients) immunodeficiency states. PCNSL tends to be supratentorial, periventricular, and involve the deep structures such as the basal ganglia. The Epstein-Barr virus (EBV) plays an important role in initiating the development of PCNSL in immunocompromised patients includinig those with HIV infection. Leukoencephalopathy i
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5

Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, Gareth Morris-Stiff, and Madhumita Bhattacharyya. Skin cancers. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199689842.003.0023_update_001.

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Tumours of the central nervous system examines the epidemiology, aetiology, genetics and pathology of these heterogeneous tumours. Clinical presentation reflects the site of origin and rate of growth. Investigation usually comprises imaging (MRI superior to CT for most), and biopsy; requirement for additional staging depends on pathology. The treatment of low-grade gliomas may be delayed if small with few symptoms, otherwise surgery and/or radiotherapy. High grade gliomas may be managed with surgery, radiotherapy, and temozolomide chemotherapy in fit patients. Unfit patients should be offered
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6

Theeler, Brett J., and Mark R. Gilbert. Primary Central Nervous System Tumors. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0129.

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Ependymomas are rare primary central nervous system (CNS) tumors that are thought to arise from ependymal cells lining the ventricular system located throughout the CNS. Ependymomas occur in all age groups but are more common in the pediatric population. Ependymomas typically present as mass lesions within the ventricular system, brain or spinal cord parenchyma. As with most central nervous system tumors, pathologic evaluation is required for definitive diagnosis. Ependymomas are typically treated with a combination of surgery and radiotherapy although this varies depending on tumor location,
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7

Yamanaka, Ryuya. Primary Central Nervous System Lymphoma: Incidence, Management and Outcomes. Nova Science Publishers, Incorporated, 2016.

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8

NCCN Guidelines for Patients® Primary Central Nervous System Lymphoma. National Comprehensive Cancer Network® (NCCN®), 2024.

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9

Burnet, Neil G., Fiona Harris, Raj Jena, Kate E. Burton, and Sarah J. Jefferies. Central nervous system tumours. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199696567.003.0016.

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Chapter 11 discusses central nervous system (CNS) tumours, including principles, planning volumes, dose distribution, high- and low-grade glioma, Ependymoma, Medulloblastoma, Germ cell tumours —germinoma and teratoma, Vestibular (acoustic) schwannoma, Pituitary tumours (including craniopharyngioma), Meningioma, and primary spinal cord tumours.
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10

Pagnoux, Christian, and Richard H. Swartz. Vasculitis of the Central Nervous System. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0099.

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Central nervous system (CNS) vasculitis is an extremely challenging diagnostic and therapeutic disease. Multiple conditions, including reversible cerebral vasoconstrictive syndrome and intracranial atherosclerosis, can mimic it. Infections, systemic diseases, particularly systemic vasculitides, drug abuse, neoplasms, and some other disorders can cause secondary CNS vasculitis. Primary CNS vasculitis is extremely rare. A definite diagnosis requires a brain biopsy, which may show granulomatous inflammation, lymphocytic inflammation, and/or acute necrotizing vasculitis. The pathogeny remains unkn
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11

Kaplan, Tamara, and Tracey Milligan. Neoplasms of the CNS (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190650261.003.0016.

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The video in this chapter discusses neoplasms of the central nervous system (CNS), including metastatic tumors, common primary brain tumors (pediatric astrocytoma, pediatric medulloblastoma, adult meningioma, and adult glioblastoma), as well as pituitary adenoma, and pineal tumors, which can present with Parinaud syndrome.
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12

Batchelor, Tracy, Ryo Nishikawa, Nancy Tarbell, and Michael Weller, eds. Oxford Textbook of Neuro-Oncology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.001.0001.

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The Oxford Textbook of Neuro-Oncology examines the epidemiology, pathogenesis, clinical features, and management of adult and childhood central nervous system (CNS) tumours. The book is organized according to the World Health Organization (WHO) classification of CNS tumours and includes an introductory chapter discussing the new, revised WHO classification that will be used in future editions of this textbook. The book reviews primary CNS tumours, metastatic CNS tumours, and familial tumour syndromes. Each chapter is organized according to a uniform framework, addressing epidemiology, aetiolog
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13

Oliver, Nora, and Elizabeth Chiao. Malignant Diseases in HIV. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0033.

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Malignancies were one of the earliest recognized manifestations that led to the eventual description of the AIDS epidemic. Kaposi’s sarcoma was one of the first entities described in association with AIDS. Subsequently, intermediate-grade and high-grade non-Hodgkin’s lymphoma, invasive cervical cancer, and primary central nervous system lymphoma were defined by the Centers for Disease Control and Prevention as “AIDS-defining conditions.” Since the advent of combination antiretroviral therapy, several other cancers that are not AIDS-defining have been found to have an increased incidence in pat
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14

Taylor, Jennie, and Patrick Y. Wen. Meningomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0130.

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Meningiomas are the most common primary brain tumor diagnosed in adults. Arising from the arachnoid (meningothelial) cells of the inner layer of the dura, they are often slow growing, but can lead to significant morbidity. They can invade through the outer layer of dura into overlying bone or skin, or into critical bordering structures such as the cavernous sinus or orbits, or encase cerebral blood vessels. These limitations can make surgical resection difficult if not impossible in some circumstance. However, they rarely metastasize outside the central nervous system (CNS), with the lungs bei
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15

Batchelor, Tracy, Joshua P. Klein, Andrés José María Ferreri, and Lisa M. DeAngelis, eds. Oxford Textbook of Neurohaematology. Oxford University PressOxford, 2024. http://dx.doi.org/10.1093/med/9780198884903.001.0001.

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Abstract The Oxford Textbook of Neurohaematology is the first dedicated source of knowledge on the diverse neurological conditions associated with malignant and classical haematological diseases. The book is divided into three sections. In the first section, neurological conditions associated with malignant haematological diseases are covered. This section begins with chapters on primary haematological malignancies of the nervous system, including primary central nervous system lymphomas, vitreoretinal lymphoma, and other rare primary malignancies such as Hodgkin disease and lymphoproliferativ
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16

Ibegbu, Chinazom, and Nimish A. Mohile. Brain Tumors in Pregnancy. Edited by Emma Ciafaloni, Cheryl Bushnell, and Loralei L. Thornburg. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190667351.003.0018.

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Approximately 79,000 people are diagnosed with a central nervous system (CNS) tumor each year, but only a few of these patients are pregnant women. There is no evidence that pregnancy confers an increased risk of developing a brain tumor and incidence during child-bearing years is estimated to be 12.24 per 100,000 women. The care and management of all patients with primary brain tumors can be challenging and requires a multidisciplinary team that includes neurologists, medical neuro-oncologists, neurosurgeons, radiation-oncologists, and palliative care physicians. In a pregnant patient, this m
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