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Dissertations / Theses on the topic 'Progenitor Fate'

Author: Grafiati

Published: 24 May 2025

Last updated: 31 July 2025

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1

Premarathne, Susitha. "Role of Deubiquitylating Enzyme USP9X in Neural Progenitor Fate Determination." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367800.

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During brain development, neural progenitors (NPs) need to balance their self-renewal with differentiation, in order to maintain the NP population while establishing the complex tissue architecture of the brain. NP fate is under the close scrutiny of plethora of fate determination factors, which can be divided into two groups based on their site of origin namely, intrinsic and extrinsic fate determinants. To date, a number of intrinsic factors, such as cell polarity and adhesion, and extrinsic factors including Notch, WNT and mTOR signaling pathways have been shown to regulate NP fate specific

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2

Toeg, Hadi D. "Role of connexin 30 in directing adult neural progenitor cell fate." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/27806.

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This thesis tested the hypothesis that the gap junction protein connexin 30 (Cx30) plays a role in regulating adult neural progenitor cell (NPC) fate. Cx30, previously shown to be expressed by postnatal astrocytes, was localized, for the first time, to adult NPCs specifically to a subset of multipotential nestin+/glial fibrillary acidic protein + (GFAP)+ NPCs in the subventricular zone (SVZ) of adult mice. When bromodeoxyuridine (BrdU) labelling was performed in Cx30 (-/-) mice, the transition of early NPCs to a neuronal lineage was reduced. Increased BrdU cell number in the rostral migratory

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3

Olabi, Safiah. "The role of β1-integrin in mammary stem and progenitor fate". Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-1integrin-in-mammary-stem-and-progenitor-fate(ce5b50f2-afaf-4cf7-a331-a429475b6cea).html.

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The mammary gland contains a subset of cells with regenerative capacity that is able to generate both luminal and myoepithelial mammary epithelial lineages. Those cells are described as mammary epithelial stem cells. The fate of stem cells is tightly controlled by their microenvironment and adhesion receptors on the stem cells play a vital role in the microenvironment–stem cell communication. They facilitate the interaction of stem cells with the extracellular matrix as well as adjacent cells, and they regulate stem cell homing to their niches, as well as stem cell proliferation, self-renewal,

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4

Forde, Sinead. "The role of the human sialomucin CD164 in regulating stem/progenitor cell fate." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442950.

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5

Melanson-Drapeau, Lysanne. "Connexin32-mediated control of progenitor cell fate in injured and uninjured adult mouse brain." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/29364.

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Gap junction protein expression has been implicated in progenitor cell proliferation, survival, and specification during development. The present study was undertaken to establish the role of the gap junction protein connexin32 in dictating progenitor cell fate in adult mouse brain. In the dentate gyrus of the hippocampus, I localized the connexin32 protein to a subset of NG2 + early oligodendrocyte progenitors. In connexin32-null mutant mice, I found an increase in the total number of proliferating early oligodendrocyte progenitors and demonstrated that the turnover of these cells is constitu

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6

Roubelakis, Maria G. "The role of SHP-2 and its partners in regulating stem/progenitor cell fate." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400441.

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7

Lutteropp, Michael. "The emergence and early fate decisions of stem and progenitor cells in the haematopoietic system." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:eef3e876-bde2-4114-8ac2-bf0c87492a55.

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The alternative road map describes the separation of lympho-myeloid and myeloid-megakaryocyte-erythroid (myeloid-Mk-E) lineages as the earliest haematopoietic commitment event. However, a number of aspects of this lineage restriction process remain poorly understood. Herein this work identified a lympho-myeloid restricted progenitor in the embryo, which resembles the adult LMPP, and demonstrated that lymphoid lineage restriction is initiated prior to definitive haematopoiesis, much earlier than previously appreciated. In vivo fate mapping showed that lympho-myeloid progenitors significantly co

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8

Tanigaki, Kenji. "Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate." Kyoto University, 2001. http://hdl.handle.net/2433/150564.

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9

Stigloher, Christian. "Specification, maintenance and fate determination of neural progenitor pools in the zebrafish central nervous system." kostenfrrei, 2008. http://mediatum2.ub.tum.de/node?id=652211.

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10

Horky, Laura L. "Fate of endogenous neural stem/progenitor cells following spinal cord injury in the adult mammal /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3112823.

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11

Saiki, Norikazu. "Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors." Kyoto University, 2018. http://hdl.handle.net/2433/232478.

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12

Qadan, Maha Ahmad. "Sourcing and Modulation of the Fate of Connective Tissue Progenitors." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1479416651140376.

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13

Yang, Yawei. "ZNF335: A Novel Regulator of Stem Cell Proliferation and Cell Fate in the Cerebral Cortex." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10682.

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Though development of the cerebral cortex is of singular importance to human cognition, it remains very poorly understood. Microcephaly, or "small head," is a neurodevelopmental disorder causing significantly reduced cerebral cortex size, and the disease has proved to be a useful model system for elucidating the steps essential for proper cortical development and cognitive function. Many known microcephaly gene products localize to centrosomes, regulating cell fate and proliferation, however, the elucidation of different microcephaly genes with different functions may shed light on previously

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14

Dyballa, Sylvia 1982. "Proneural gene requirements and progenitor dynamics in sensory organ development." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/399037.

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The inner ear is the sensory organ for hearing and balance. Its functional unit is the sensory patch that comprises: i) hair cells, which are the mechano- transducers sensing the stimuli and are embedded in the supporting cell layer, and ii) sensory neurons, which conduct these stimuli to the hindbrain. The generation of hair cells and neurons occurs in the otic placode early during embryonic development. Cell fate specification relies on expression of proneural genes and is concomitant with organ growth and morphogenesis. We used zebrafish embryos and combined live imaging and genetic tools t

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15

Belzunce, Guillermo Ivan 1992. "Uncovering the interplay between call fate specification and progenitor dynamics during the development of the lower rhombic lip." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668134.

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The Lower Rhombic Lip (LRL) is a transient neuroepithelial structure of dorsal hindbrain that gives rise to deep brainstem nuclei like the vestibular, auditory and precerebellar nuclei. In this work, we have followed the LRL-progenitor cell population through early steps of neurogenesis and hindbrain morphogenesis to understand proneural function and progenitor dynamics during neuronal specification. We provide information about the atoh1 gene regulatory network operating in the specification of LRL cells, and the kinetics of cell proliferation and behaviour of atoh1a-derivatives by using func

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16

Jadasz, Janusz J. [Verfasser]. "Fate modulation of oligodendroglial progenitor cells and adult neural stem cells : p57kip2 and adult gliogenesis / Janusz J. Jadasz." Berlin : epubli GmbH, 2014. http://d-nb.info/106321999X/34.

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Jadasz, Janusz [Verfasser], Patrick [Akademischer Betreuer] Küry, and Hermann [Akademischer Betreuer] Aberle. "Fate modulation of oligodendroglial progenitor cells and adult neural stem cells / Janusz Jadasz. Gutachter: Patrick Küry ; Hermann Aberle." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2014. http://d-nb.info/1051734673/34.

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18

Chwastek, Damian. "Elucidating the Contribution of Stroke-Induced Changes to Neural Stem and Progenitor Cells Associated with a Neuronal Fate." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41839.

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Following stroke there is a robust increase in the proliferation of neural stem and progenitor cells (NSPCs) that ectopically migrate from the subventricular zone (SVZ) to surround the site of damage induced by stroke (infarct). Previous in vivo studies by our lab and others have shown that a majority of migrating NSPCs when labelled prior to stroke become astrocytes surrounding the infarct. In contrast, our lab has shown that the majority of NSPCs when labelled after stroke become neurons surrounding the infarct. This thesis aims to elucidate the contributions of intrinsic changes that can al

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19

Zhang, Yan. "In vitro Functional Properties and In vivo Local Effects of Transplanted Human Progenitor Cells in Ischemic Tissues." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20216.

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Growing evidence from animal and clinical studies suggests that cardiac cell therapy can restore perfusion and improve function in the ischemic/infarcted myocardium. However, cell therapy is hindered by insufficient cell numbers, inefficient cell homing and engraftment, and inadequate cellular interactions. Furthermore, the biological mechanisms and local effects of transplanted cells have not been well-elucidated. The research presented herein attempts to address some of these issues. In manuscript #1, a new subpopulation of circulating progenitor cells (CPCs), termed derived CD133+ cells, wa

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20

Belian, Elisa. "The instructive role of cardiac transcription factors in triggering transition of cardiac progenitor cells into the cardiac muscle fate." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/40196.

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The mechanisms that maintain cardiac progenitor cells (CPCs) in a state of arrested development and prevent their spontaneous differentiation are unknown. This study is aimed at investigating potential mechanisms responsible for the striking paradox of cardiac transcription factors' expression without activation of their direct cardiomyocyte-specific target genes. Expression analysis of a range of CPC-derived clonal lines, characterised by Sca-1 expression and the SP phenotype, showed that all analysed cardiac transcription factors are expressed as nuclear-localised proteins. Hence, the absenc

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21

Luche, Hervé. "Towards the identification of the thymus seeding progenitor: "fate mapping" of early T-cell stages using gene "knock-in" strategies." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-59434.

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22

Factor, Daniel C. "Understanding Epigenetic Controllers of Stem Cell Fate and Function." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1504285124759387.

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23

Pensold, Daniel [Verfasser], Geraldine [Gutachter] Zimmer, Aria [Gutachter] Baniahmad, and Tomas [Gutachter] Pieler. "Single cell transcriptomics reveal regulators of progenitor cell fate and postmitotic maturation during brain development / Daniel Pensold ; Gutachter: Geraldine Zimmer, Aria Baniahmad, Tomas Pieler." Jena : Friedrich-Schiller-Universität Jena, 2017. http://d-nb.info/1177600617/34.

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24

De, Bono Christopher. "Investigation of mechanisms regulating second heart field progenitor cell addition to alternate poles of the mouse heart and the regulation of myogenic fate in cardiopharyngeal mesoderm." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0436/document.

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Chez les vertébrés, les cellules progénitrices du second champ cardiaque (SHF) situées dans le mésoderme cardiopharyngé (CPM) s’ajoutent aux pôles artériel et veineux du tube cardiaque embryonnaire et contribuent à son élongation. La perturbation de ce processus se traduit par un spectre de défauts cardiaques congénitaux. Les cellules situées dans les domaines antérieur et postérieur du SHF forment deux sous-populations de progéniteurs qui contribuent respectivement au myocarde du ventricule droit et de la voie efférente au pôle artériel et au myocarde auriculaire au pôle veineux. Des expérien

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25

Ghigo, Clément. "Etude de l'homéostasie et du renouvellement des cellules de Langerhans et des lymphocytes T dendritiques de l'épiderme." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4026.

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La peau est un organe très exposé à l’environnement et fournit la première ligne de défense contre de nombreux pathogènes. Cette fonction est remplie dans l’épiderme murin par les cellules de Langerhans (LCs) et les cellules T dendritiques de l’épiderme (DETCs). Alors que le développement de ces cellules a bien été étudié, peu d’expériences ont été effectuées sur leur renouvellement en condition homéostatique chez des animaux adultes sans manipulations. Nous avons alors développé un système de traçage cellulaire par fluorescence multicolore pour étudier l’homéostasie des LCs et des DETCs. Cett

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26

Chiron, Andrada-Silvana. "Investigation into the role of erythropoietin in B cell lymphopoiesis." Electronic Thesis or Diss., Université Paris Cité, 2024. http://www.theses.fr/2024UNIP5262.

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L'érythropoïétine (EPO) est une hormone produite principalement par les reins, dont la fonction essentielle consiste à assurer l'érythropoïèse. Sa concentration systémique augmente en réponse à l'anémie ou à l'hypoxie. En plus de cette production endogène, l'EPO humaine recombinante est couramment utilisée pour traiter l'anémie des patients atteints d'insuffisance rénale chronique ou de cancer. Les effets immunomodulateurs/immunosuppresseurs de l'EPO sur les lymphocytes matures et plus généralement sur les cellules immunitaires ont été bien étudiés. Cependant, son rôle dans la lympho-hématopoï

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27

Rondeau, Vincent. "Rôle de la désensibilisation de CXCR4 dans la spécification lympho-myéloïde des progéniteurs hématopoïétiques multipotents. Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization New method to obtain lymphoid progenitors CXCR4-driven mitochondrial metabolic pathways shape the lympho-myeloid fate of hematopoietic multipotent progenitors." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ022.

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Les cellules souches et progéniteurs hématopoïétiques (CSPHs), incluant les progéniteurs multipotents (MPPs), sont responsables de la production des cellules immunes circulantes. Ils résident dans la moelle osseuse (MO) au sein de structures spécialisées, les niches endostéale et (péri)-vasculaire, qui régulent la spécification et l'engagement lymphoïde versus myéloïde des CSPHs. Dans la MO, le couple formé par la chimiokine CXCL12 et l’un de ses récepteurs, CXCR4, exerce un rôle clé dans la régulation de la rétention et la quiescence des CSPHs. Ces processus sont dérégulés dans le Syndrome WH

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28

Minchin, James. "Pax3 genes drive cell fate choice in tissue-restricted progenitors." Thesis, King's College London (University of London), 2009. https://kclpure.kcl.ac.uk/portal/en/theses/pax3-genes-drive-cell-fate-choice-in-tissuerestricted-progenitors(746b8b18-c26e-49ac-aac4-835074e198fa).html.

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29

Voltes, Cobo Adrià 1991. "Hindbrain boundaries : addressing the crossroad between tissue segmentation and cell fate regulation." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665625.

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The hindbrain boundary cell population (BCP) is specified at the interface between adjacent compartments during embryonic development of the posterior brain. Hindbrain BCP is a non-neurogenic population that acts as both a signaling center and an elastic mesh that prevents cell intermingling between adjacent compartments. Remarkably, boundary cells display mechanical characteristics that emphasize the impact of tissue segmentation on boundary architecture: they display specific cell morphology and contain actomyosin cable-like structures that provide the boundaries with the tension necessary f

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30

Lumbers, Richard Thomas. "Towards high content assays of cell fate in adult cardiac progenitors." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/32256.

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Expression of the stem cell antigen-1 (Sca1) denotes cardiac progenitors in the adult mouse heart and a clonogenic subset (CSP) is identified by the side population phenotype. Clonal CSP cells differentiate to cardiomyocyte, endothelial and smooth muscle lineages when grafted in vivo; however, the instructive signals directing adoption of these fates are unknown. Similarly, in vitro conditions for directed differentiation of CSP have yet to be defined. To facilitate high content screening approaches for the investigation of signals directing cardiomyocyte differentiation, a lentiviral fluoresc

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Sznurkowska, Magdalena Katarzyna. "Defining lineage potential and fate behaviour of progenitors during pancreas development." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274097.

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32

Chapman, Heather M. "Gsx genes control the neuronal to glial fate switch in telencephalic progenitors." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1394725163.

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33

Asscher, Eva Constance Alida. "Fate mapping the progenitors located in the superficial layer of the Xenopus laevis neural plate." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614129.

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34

Huang, Yali. "Investigating the spatiotemporal dynamics and fate decisions of axial progenitors and the potential of their in vitro counterparts." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/21687.

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Elongation of the mouse anteroposterior axis depends on stem cell-like axial progenitors including a neuromesodermal (NM) bi-fated population existing in the primitive streak and later in the tail bud. Fate mapping experiments have demonstrated these NM progenitors reside in precise locations of the embryo. At E8.5, these cells are found in the node-streak border (NSB) and anterior epiblast on either side of the primitive streak. At tail bud stages (E10.5-E13.5), these progenitors reside in the chordoneural hinge (CNH). The coexpression of the transcription factors T (brachyury) and Sox2 has b

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BIANCOTTO, CHIARA. "EXPRESSION AND INITIAL CHARACTERIZATION OF THE CELL FATE TRANSCRIPTION FACTOR PRDM1 IN ADULT NEURAL PROGENITORS AND GLIOBLASTOMA MULTIFORME." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/219068.

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PRDM1 is a master transcriptional regulator in multiple cell lineages and it is required for the development of many species. However the reason and the mechanisms underlying its pleiotropic functions remain largely unknown as the full array of tissues and target genes controlled by PRDM1. Our results indicate a completely unexplored field where to study PRDM1 regulatory network that is the brain and its most aggressive cancer, the Glioblastoma multiforme (GBM). We identified that PRDM1 is expressed in adult neural progenitor cells and that it correlates with the maintenance of cellular multip

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Edri, Shlomit. "Date with destiny : genetic and epigenetic factors in cell fate decisions in populations of multipotent stem cells." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288380.

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The governance of cell fate decisions during development is a fundamental biological problem. An important aspect of this is how cells exit a multipotent state and choose their fates in a correct manner and proportion. To tackle an aspect of this problem, I have focused on 2 multipotent models: one infinite self-renewal pluripotency in an artificial environment, and the other, bipotent progenitors in the context of the mouse embryo. The first model aimed to explore the effects of chromatin-associated factors on the ability of pluripotent mouse Embryonic Stem Cells (ESCs) to self-renew, via mon

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Belmonte, Mateos Carla 1992. "Unveiling the molecular and behavioral properties of hindbrain rhombomere centers." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673433.

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Precise regulation of neurogenesis is achieved by differentially allocating the neurogenic competence along the tissue. In the hindbrain proneural gene expression is stereotypically confined in segment boundary-adjacent regions, hence, being absent in segment centers. This segregation of proneural gene expression therefore hints rhombomere centers as a putative non-neurogenic population. In this work, we unveil their spatiotemporal molecular profile as well as one of the mechanisms involved in their maintenance as non-committed progenitors. By 4D imaging we shed light for the first time in

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Dudhal, Swati. "Selenoprotein N as a novel regulator of the muscle progenitor’s cell fate decision process : balancing differentiation and self-renewal." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC288.

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Les mutations du gène codant la sélénoprotéine N (SEPN1) provoquent une myopathie congénitale nommée SEPN1-related myopathy (SEPN1-RM), caractérisée par une faiblesse et une amyotrophie majeures des muscles du cou et du tronc, une scoliose et une insuffisance respiratoire potentiellement létale. SEPN1-RM a été associée avec un stress oxydant, une diminution de la population de cellules souches musculaires (cellules satellites) et des défauts de la régénération musculaire. Avec l’objectif de rechercher les mécanismes impliqués dans ces défauts, et en particulier un rôle potentiel de SEPN1 dans

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Pellegrini, Pasquale 1983. "RANK signaling, a master regulator of mammary stemness and cancer : characterization of RANK and RANKL pathway stem cell fate, tumorigenesis and metastasis." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/586316.

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RESUME RANK signaling is essential for mammary gland development and progesterone induced tumorigenesis. Here we show that RANK controls mammary stem cell fate; increased RANK signaling results in accumulation of stem and progenitor cells leading to spontaneous tumor formation. RANK signaling interferes with alveolar commitment through depletion of CD61+ alveolar progenitors and regulation of Elf-5/STAT5 pathway. Using pharmacological and genetic approaches we show that RANK signaling promotes tumor initiation, progression and metastasis in spontaneous breast cancer models and expands tumor in

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Tognatta, Reshmi [Verfasser]. "CNP-expressing progenitors display strikingly differential oligodendroglial or multipotent fates, as assessed by two Cre reporter lines / Reshmi Tognatta." Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1044867574/34.

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Pagano, Allan. "Déconditionnement et régénération du muscle strié squelettique : rôle du niveau d’activité contractile sur le développement d’infiltrations graisseuses." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONT4004/document.

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Le muscle strié squelettique est un tissu fascinant qui permet d’assurer les fonctions essentielles à notre existence : se mouvoir, maintenir sa posture, se nourrir, communiquer ou tout simplement respirer. De nombreuses situations, engendrant principalement une hypoactivité, peuvent provoquer un déconditionnement musculaire caractérisé par une perte de masse et de force ainsi qu’un développement d’infiltrations graisseuses (IMAT), altérant ainsi la fonction musculaire. Le développement d’IMAT est également observé lorsque les processus de régénération musculaire sont altérés. Les fibro-adipog

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Della, Bella Elena <1983&gt. "Progenitori endoteliali nei pazienti con Chronic Kidney Disease - Mineral and Bone Disorder (CKD-MBD) in fase uremica: effetti del trattamento con vitamina D." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4636/1/DellaBella_Elena_Tesi.pdf.

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L'insufficienza renale cronica (CKD) è associata ad un rischio cardiovascolare più elevato rispetto alla popolazione generale: fattori come uremia, stress ossidativo, età dialitica, infiammazione, alterazioni del metabolismo minerale e presenza di calcificazioni vascolari incidono fortemente sulla morbosità e mortalità per cause cardiovascolari nel paziente uremico. Diversi studi hanno verificato il coinvolgimento dei progenitori endoteliali (EPC) nella malattia aterosclerotica ed è stato dimostrato che esprimono osteocalcina, marcatore di calcificazione. Inoltre, nella CKD è presente una d

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Della, Bella Elena <1983&gt. "Progenitori endoteliali nei pazienti con Chronic Kidney Disease - Mineral and Bone Disorder (CKD-MBD) in fase uremica: effetti del trattamento con vitamina D." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4636/.

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L'insufficienza renale cronica (CKD) è associata ad un rischio cardiovascolare più elevato rispetto alla popolazione generale: fattori come uremia, stress ossidativo, età dialitica, infiammazione, alterazioni del metabolismo minerale e presenza di calcificazioni vascolari incidono fortemente sulla morbosità e mortalità per cause cardiovascolari nel paziente uremico. Diversi studi hanno verificato il coinvolgimento dei progenitori endoteliali (EPC) nella malattia aterosclerotica ed è stato dimostrato che esprimono osteocalcina, marcatore di calcificazione. Inoltre, nella CKD è presente una d

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Dursun, Ezgi [Verfasser], Anne [Akademischer Betreuer] Krug, Thomas [Gutachter] Korn, and Markus [Gutachter] Gerhard. "Cell fate decisions of common dendritic cell progenitors characterized by continuous live cell imaging at the single cell level / Ezgi Dursun ; Gutachter: Thomas Korn, Markus Gerhard ; Betreuer: Anne Krug." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1114393983/34.

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Bom, Eliane Aparecida 1978. "Influência da fisioterapia respiratória na evolução das condições respiratórias de pacientes na fase precoce do transplante mieloablativo de células progenitoras hematopoiéticas (TCPH)." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313408.

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Orientador: Cármino Antonio de Souza<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas.<br>Made available in DSpace on 2018-08-18T19:05:15Z (GMT). No. of bitstreams: 1 Bom_ElianeAparecida_M.pdf: 1448559 bytes, checksum: 25012b57d1d19d99fb859ba48f6615c3 (MD5) Previous issue date: 2011<br>Resumo: A fisioterapia respiratória (FR) como prevenção e/ou tratamento de complicações respiratórias integra o arsenal de cuidados ao paciente submetido ao transplante de células progenitoras hematopoéticas (TCPH). As complicações pulmonares ocorrem em 40 a 60% dos

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Souza, Mair Pedro de [UNESP]. "Impacto da introdução do regime de condicionamento Fludarabina e Busulfano, no transplante alogênico de células progenitoras hematopoiéticas para portadores de Leucemia Mielóide Crônica, em fase crônica: a experiência de um centro brasileiro." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/88100.

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Made available in DSpace on 2014-06-11T19:23:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-26Bitstream added on 2014-06-13T19:49:53Z : No. of bitstreams: 1 souza_mp_me_botfm.pdf: 6711737 bytes, checksum: 1ecb9df853dbd806868302e90e1916ee (MD5)<br>Fundação Amaral Carvalho<br>Estudo retrospectivo com a finalidade de avaliar o impacto da introdução de um regime alternativo de condicionamento para transplantes de medula óssea alogênicos com doadores aparentados, totalmente compatíveis, portadores de Leucemia Mielóide Crônica, em Fase Crônica. No período de agosto de 1996 a julho de

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Souza, Mair Pedro de. "Impacto da introdução do regime de condicionamento Fludarabina e Busulfano, no transplante alogênico de células progenitoras hematopoiéticas para portadores de Leucemia Mielóide Crônica, em fase crônica : a experiência de um centro brasileiro /." Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/88100.

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Resumo: Estudo retrospectivo com a finalidade de avaliar o impacto da introdução de um regime alternativo de condicionamento para transplantes de medula óssea alogênicos com doadores aparentados, totalmente compatíveis, portadores de Leucemia Mielóide Crônica, em Fase Crônica. No período de agosto de 1996 a julho de 2008, foram incluídos 158 pacientes, analisados em dois diferentes momentos: o primeiro inclui os pacientes transplantados antes de 2004, quando 72(45%) deles, foram tratados com a combinação Busulfano e Ciclofosfamida (BUCY). Neste período inicial os dados demonstraram melhores re

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Kratchmarov, Radomir. "Metabolism regulates cell fate in lymphocytes and progenitor cells." Thesis, 2018. https://doi.org/10.7916/D8G46270.

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Self-renewal mediates homeostasis across mammalian organ systems as the cellular components of mature tissues are continually replaced in the face of wear and tear, injury, infection, and malignancy. The hematopoietic and immune systems are crucial for organismal longevity and rely on the ability of progenitor cells to bifurcate in fate to produce mature terminally differentiated progeny while self-renewing to maintain more quiescent progenitors. Asymmetric cell division is associated with self-renewal of lymphocytes and hematopoietic progenitors, but the mechanisms underlying the cell biology

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Hsieh, Ming-Yi. "Hydrogel/Electrospun Fiber Composites Influence Neural Stem/Progenitor Cell Fate." Thesis, 2009. http://hdl.handle.net/1807/25703.

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Cell replacement therapy with multi-potent neural/stem progenitor cell into the injured spinal cord is limited by poor survival and host tissue integration. An injectable and biocompatible polymeric cell delivery system serves as a promising strategy to facilitate cell delivery, promote cell survival and direct cell behaviour. We developed and characterized the use of a physical hydrogel blend of hyaluronan and methylcellulose for NSPC delivery, and incorporated electrospun fibers of collagen or P(CL:DLLA) to promote cell-matrix interactions and influence cell behaviour. HAMC was shown to be b

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Kim, Howard. "Directed Adult Neural Stem/Progenitor Cell Fate in Microsphere-loaded Chitosan Channels." Thesis, 2011. http://hdl.handle.net/1807/31804.

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Spinal cord injury (SCI) is a devastating condition characterized by the loss of neuronal pathways responsible for coordinating motor and sensory information between the brain and the rest of the body. The mammalian spinal cord is limited in its ability to repair itself, so treatments devised to replace damaged tissue and promote regeneration are essential towards developing a cure. This work describes the development of a guidance channel strategy for spinal cord transection. Chitosan guidance channels were designed as a delivery vehicle for neural stem/progenitor cell (NSPC) transplants and

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