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Dissertations / Theses on the topic 'Prolines'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Francart, Céline. "Etude par resonance magnetique nucleaire de polypeptides contenant plusieurs prolines." Lille 2, 1997. http://www.theses.fr/1997LIL2P269.

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2

Garcia, Ariel Lazaro Llanes. "Reação de arilação de Heck com sais de arenodiazonio : aplicações nas sinteses totais de prolinas e pirrolidinas poliidroxiladas, rolipram e analogos do baclofeno, e na sintese formal de prepolicitrina A e policitrina A." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248358.

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Orientador: Carlos Roque Duarte Correia<br>Acompanha Anexo denominado V.2. Paginação continua<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-12T12:04:47Z (GMT). No. of bitstreams: 1 Garcia_ArielLazaroLlanes_D.pdf: 15520800 bytes, checksum: 2744757a92f3045d187a1c68320729d5 (MD5) Previous issue date: 2008<br>Resumo: A reação de arilação de Heck-Matsuda é um procedimento sintético valioso e extremamente versátil para a formação de ligações carbono-carbono, baseada no acoplamento de uma olefina com um sal de arenodiazônio na p

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3

Beausoleil, Éric. "Interactions stériques à l'intérieur de peptides contenant des prolines non-naturelles." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ56460.pdf.

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4

Rajkovic, Andrei. "Promoting Bacterial Synthesis of Oligo-prolines by Modifying Elongation Factor P Post-translationally." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469123846.

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5

Lacambra, Aitor. "Nouvelle méthode pour des réactions de cycloaddition/désaromatisation stéreocontrolées sous conditions catalytiques." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0576/document.

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Les alcaloïdes sont, en général, une famille de composés hétérocycliquesd'origine végétale qui intègrent des atomes d'azote dans leur structure complexe.Leur intérêt réside dans les activités biologiques intéressantes qu'ils présentent, etpour cette raison, ils sont largement utilisés par l'industrie pharmaceutique. Enparticulier, les anneaux de pyrrolidine et de pipéridine se trouvent comme basefondamentale dans un grand nombre de telles structures. D'autre part, l'un desprincipaux objectifs de la chimie synthétique est d'obtenir ces types de moléculesd'une manière asymétrique. Entre autres,

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6

Rahgoshay, Keyvan. "Incorporation de prolines et pseudoprolines fluorées dans des chaînes peptidiques, conséquences conformationnelles et applications." Thesis, Cergy-Pontoise, 2019. http://www.theses.fr/2019CERG1037.

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Cette thèse porte sur la synthèse d’analogues fluorés de mimes de collagène synthétique et sur l’étude de leurs caractéristiques thermodynamiques, cinétiques et structurales. Notre laboratoire a récemment mis au point la synthèse d'acides aminés fluorés mimes de la proline (pseudoprolines). Dans un premier temps, une étude préliminaire a été effectuée sur des triplets monomériques modèles afin de confirmer l'aptitude de nos mimes fluorés à stabiliser les conformations pré-requises pour la structuration en triple hélice du collagène. Une fois celles-ci confirmées, nous avons ensuite mis au poin

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7

Cai, Chaozhong. "Asymmetric synthesis of chi-constrained pyroglutamic acids, glutamic acids and prolines for peptides and peptidomimetics." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/280129.

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The recent upsurge of interest in the peptide-based drug molecules has been accompanied by a great deal of attention to the design of stereochemically defined non-proteinogenic amino acids. As a continuous effort to develop efficient syntheses of χ-constrained amino acids in our group, we recently have developed a practical methodology for the asymmetric synthesis of substituted pyroglutamic acid, glutamic acid and proline analogues, which are of important use in examining the relationships between conformation and bioactivities of biologically important peptides (e.g. DPDPE, α-MSH). The key s

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8

Quan, Chao. "Xenobiotics of primary billiary cirrhosis, synthesis of unnatural prolines and solid synthesis of heterocyclic libraries /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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9

Marotta, Nicole. "Mycoplasma pneumoniae protein P30 proline residues: Cytadherence, gliding motility, and P30 stability." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1412010755.

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10

Foloppe, Marie-Paule. "Synthèse et étude physico-chimique de N-(benzoyl) prolines et de pyrrolo (2,1-c) (1,4) benzodiazépines à visée thérapeutique." Caen, 1994. http://www.theses.fr/1994CAEN4057.

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11

Quancard, Jean. "Synthèse d'acides aminés contraints dérivés de la proline : application à l'étude d'interactions peptide/protéine." Paris 6, 2004. http://www.theses.fr/2004PA066487.

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12

Simon, Julien. "Etude méthodologique du couplage d’acides aminés trifluorométhylés et application à la synthèse d’analogues du GPE, un tripeptide à visée thérapeutique." Thesis, Cergy-Pontoise, 2012. http://www.theses.fr/2012CERG0596/document.

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Le tripeptide GPE possède une activité neuroprotectrice intéressante in-vitro et in-vivo pour différents types de dommage neuronaux. L'objectif de cette thèse est de mettre au point des méthodes de couplage peptidique pour les acides aminés trifluorométhylés et de réaliser des analogues trifluorométhylés du GPE.Au cours de cette thèse, la synthèse d'acides aminés trifluorométhylés cycliques énantiopurs (proline, pseudoproline) a été réalisée à l'échelle du gramme.Ensuite, une étude méthodologique de l'incorporation de ces acides aminés trifluorométhylés dans des peptides a été effectuée.Des ex

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13

Kubyshkin, Volodymyr [Verfasser], and A. S. [Akademischer Betreuer] Ulrich. "Fluoro-substituted prolines as structural labels for solid state 19F-NMR of polypeptides / Volodymyr Kubyshkin. Betreuer: A. S. Ulrich." Karlsruhe : KIT-Bibliothek, 2012. http://d-nb.info/1036206858/34.

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14

Godoi, Marla Narciso. "Síntese de 4- e 5-arilprolinas através da reação de Heck-Matsuda e sua utilização como organocatalisadores em reações aldólicas e Mannich multicomponente." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249880.

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Orientador: Carlos Roque Duarte Correia<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-16T16:31:07Z (GMT). No. of bitstreams: 1 Godoi_MarlaNarciso_D.pdf: 10035986 bytes, checksum: 6deb65c44c4239f0ee6985fb972c18b1 (MD5) Previous issue date: 2010<br>Resumo: Este trabalho de tese visou desenvolver rotas sintéticas eficientes para síntese de prolinas ariladas utilizando como etapa-chave a reação de arilação de Heck-Matsuda. Além disso, os aminoácidos arilados tiveram seu potencial organocatalítico avaliado frente a reações ald

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15

Simon, Julien. "Etude méthodologique du couplage d'acides aminés trifluorométhylés et application à la synthèse d'analogues du GPE, un tripeptide à visée thérapeutique." Phd thesis, Université de Cergy Pontoise, 2012. http://tel.archives-ouvertes.fr/tel-00816535.

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Le tripeptide GPE possède une activité neuroprotectrice intéressante in-vitro et in-vivo pour différents types de dommage neuronaux. L'objectif de cette thèse est de mettre au point des méthodes de couplage peptidique pour les acides aminés trifluorométhylés et de réaliser des analogues trifluorométhylés du GPE.Au cours de cette thèse, la synthèse d'acides aminés trifluorométhylés cycliques énantiopurs (proline, pseudoproline) a été réalisée à l'échelle du gramme.Ensuite, une étude méthodologique de l'incorporation de ces acides aminés trifluorométhylés dans des peptides a été effectuée.Des ex

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16

Babot, Marion. "Le transporteur ADP/ATP mitochondrial : études fonctionnelles des prolines des hélices transmembranaires 1, 3 et 5 et étude des conformations associées au transport de nucléotides." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21834/document.

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Le transporteur mitochondrial de nucléotides adényliques (Ancp), localisé dans la membrane interne mitochondriale, catalyse l'échange ADP/ATP entre le cytoplasme et la matrice mitochondriale. Il lie deux classes d'inhibiteurs naturels avec une grande spécificité et une haute affinité. Ces deux types d'inhibiteurs, BA et CATR, stabilisent Ancp dans deux conformations distinctes impliquées dans le transport des nucléotides. La compréhension des changements conformationnels subits par Ancp est essentielle pour décrire précisément le mécanisme d'échange des nucléotides. La structure atomique du tr

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17

Chantreau, Vanessa. "Rôle des prolines des hélices 2 et 5 dans le mécanisme d’activation des récepteurs couplés aux protéines G : Exemples du récepteur de la thyrotropine et du récepteur 2 de la vasopressine." Thesis, Angers, 2014. http://www.theses.fr/2014ANGE0041.

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Objectifs : Les Récepteurs Couplés aux Protéines G (RCPG) constituent une grande famille ubiquitaire. Leur structure est caractérisée par sept hélices transmembranaires. Les déformations de ces hélices jouent un rôle majeur dans l’activation de ces récepteurs. La plupart de ces déformations sont liées à la présence de prolines conservées. Cependant, les prolines de l’hélice 2 et 5 des RCPG ne sont pas systématiquement présentes. De plus, la position de la proline dans l’hélice 2 est variable (2.58, 2.59 ou 2.60). Nous nous intéressons aux rôles des prolines des hélices 2 et 5 dans l’activation

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18

Hu, Zilun. "CONSTRAINED β–PROLINES: I. METHANOPYRROLIDINE β-AMINO ACIDS: SYNTHESIS AND CHARACTERIZATION OF NOVEL C6- SUBSTITUTED ANALOGUES AND PEPTIDE OLIGOMERS II. SYNTHESIS OF 2,2-DISUBSTITUTED PYRROLIDINE-3-CARBOXYLIC ACIDS". Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/339315.

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Chemistry<br>Ph.D.<br>In the study of structurally restricted cyclic β-amino acids and peptides, methanopyrrolidine-5-carboxylic acids (MetPyr-5-acids), or 5-syn-carboxy-2-azabicyclo[2.1.1] hexanes, and derivatives were investigated. MetPyr-5-acids are a series of highly conformationally constrained β-proline derivatives, which belong to a novel category of β-amino acids utilized as building blocks for the synthesis of β-peptides. These β-peptides lack the backbone hydrogen bonds necessary for folding in the usual manner. Substituents and functional groups in this ring system were envisioned t

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19

Mattay, Johanna [Verfasser], and Wolfgang [Akademischer Betreuer] Hüttel. "Selectivity and substrate specificity in proline and pipecolic acid hydroxylases = Selektivität und Substratspezifität in Prolin- und Pipecolinsäurehydroxylasen." Freiburg : Universität, 2017. http://d-nb.info/1153335395/34.

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20

Vieira, Lisvane Paes. "Caracterização molecular e bioquímica da prolina desidrogenase de Trypanosoma cruzi, um possível alvo terapêutico." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-09122010-102717/.

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Os nossos resultados demonstraram a atividade enzimática prolina desidrogenase (PRODH) do produto do gene anotado como codificante de uma prolina oxidase na base dados do genoma de Trypanosoma cruzi. A atividade da proteína codificada por esse gene foi avaliada inicialmente por complementação de uma linhagem de S. cerevisiae deficiente na expressão funcional da PRODH endógena, e posteriormente mediante a obtenção da enzima recombinante ativa expressa em um sistema bacteriano. Nos estudos feitos tanto com leveduras complementadas com o gene PRODH, quanto com as formas epimastigotas de T. cruzi

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21

Rocha, Sandra Carla. "A prolinemia como um fator de severidade na infecção causada pelo Trypanosoma cruzi." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-14032016-104826/.

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Foi demonstrado que a L-prolina é fundamental para o metabolismo das formas intracelulares de T.cruzi e está envolvida em processos de resistência a diferentes condições de estresse. O ácido L-tiazolidina-4-carboxílico (T4C) age como inibidor competitivo do transporte de prolina para o interior do parasita, desta forma, pode-se assumir que, quando aplicado como agente terapêutico simula uma situação de hipoprolinemia no hospedeiro mamífero. Sobre esta base, propomos que a prolinemia poderia estar relacionada com a severidade da infecção pelo T. cruzi, portanto, decidimos inverter o racional e

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22

Urbonienė, Regina. "Skirtingų žieminių kviečių veislių žiemkentiškumo įvertinimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110603_114927-08819.

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2009–2011 metais Lietuvos Žemės ūkio universiteto Bandymų stotyje, karbonatingame sekliai glėjiškame išplautžemyje (Calc(ar)i-Epihypogleyic Luvisols) IDg8-k (LVg-p-w-cc) atlikti tyrimai, siekiant įvertinti skirtingų žieminių kviečių veislių žiemkentiškumą. Fotosintezės pigmentų didžiausias kiekis nustatytas rudens-žiemos periodu, o pavasario pradžioje fotosintezės produktyvumas buvo mažiausias. Nustatyta, kad labai gerų kepimo sąvybių ’Ada’ linkusi kaupti didesnius fotosintezės pigmentų kiekius, lyginant su gerų kepimo savybių ’Tauras DS’. Didžiausias sacharidų kiekis (447,2 mg g-1) nustatyt

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23

Jonytienė, Vaida. "Endogeninių ir egzogeninių veiksnių poveikis žieminio rapso (Brassica napus L.) užsigrūdinimui ir atsparumui šalčiui in vitro ir in vivo." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120529_211218-52148.

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Darbo tikslas – nustatyti endogeninių ir egzogeninių veiksnių poveikį žieminio rapso atsparumui šalčiui in vitro ir in vivo. Ginamieji disertacijos teiginiai: 1. Žieminio rapso atsparumas šalčiui didžiąją dalimi lemiamas endogeninio prolino, o ne tirpiųjų sacharidų kiekio augalų audiniuose. 2. Grūdinant ūglius in vitro egzogeniniai priedai (abscizo rūgštis, prolinas, tirtas aminorūgščių kompleksas) maitinamojoje terpėje didina atsparumą šalčiui. 3. In vitro sistemoje L-prolinas ir tirtas aminorūgščių kompleksas atstato atlydžio metu sumažėjusį užsigrūdinimo tvarumą. 4. Endogeninio prolino kiek

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24

Klimas, Tautvydas. "Drėgmės trūkumo poveikis žirnių morfofiziologiniams rodikliams." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140616_130419-15001.

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Magistrantūros studijų baigiamajame darbe pateikiami žirnių fotosintezės pigmentų, prolino, sacharidų bei santykinės drėgmės pokytis lapuose esant drėgmės deficitui. Tyrimų objektas – `Ilgiai` veislės sėjamasis žirnis (Pisum sativum L.). Darbo metodai. Tyrimai atlikti Aleksandro Stulginskio universiteto Agrobiotechnologijos laboratorijoje 2012-2013 metais. Žirniai pasėti į 0,16 m x 0,23 m (aukštis x diametras) vegetacinius indus su substratu (pH − 6,31, P2O5 − 633,94 mg kg-1, K2O – 912 mg kg-1). Eksperimentas vykdytas 6 pakartojimais po 5 augalus inde. Augalai auginti programuojamoje auginimo

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25

Hsueh, Li-Ching. "Studies on proline hydroxylases." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365805.

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26

Santos, Ricardo Barbosa dos. "Cultivares de cana-de-açúcar submetido à restrição hídrica." Universidade Federal de Sergipe, 2011. http://ri.ufs.br:8080/xmlui/handle/123456789/2714.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The increasing demand for biofuels has provided significant increases in the areas of sugar cane in Brazil and in recent decades,and long periods of drought have limited the production of this species. This study aimed to evaluate the performance of cultivars RB 85-5536 and RB 93-509 of cane sugar on water restriction during the first stages of development. Experiment was carried out in the greenhouse of the Department of Agronomic Engineering at UFS in randomized blocks in factorial2 x 4, two cultivars (RB 85-5536 and RB 93-509)

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27

KuÌˆllchen, Felix B. "Studies on proline 3-hydroxylase." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269221.

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28

Townsend, David E. Wilkinson Brian J. "Proline transport and biosynthesis in Staphylococcus aureus." Normal, Ill. Illinois State University, 1992. http://wwwlib.umi.com/cr/ilstu/fullcit?p9311291.

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Thesis (Ph. D.)--Illinois State University, 1992.<br>Title from title page screen, viewed February 6, 2006. Dissertation Committee: Brian J. Wilkinson (chair), Radheshyam Jayaswal, Herman E. Brockman, Robert L. Preston, Philip D. Morse. Includes bibliographical references (leaves 107-112) and abstract. Also available in print.

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29

Le, Dinh Thien. "Métabolisme de la proline chez les mammifères." Paris 5, 1988. http://www.theses.fr/1988PA05P216.

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30

Daza, Jorge Humberto Unas. "Produção e caracterização do biossurfatante produzido pela bactéria marinha Brevibacterium luteolum." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-15092015-140809/.

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Os biossurfatantes (BS) são produtos de origem microbiana com propriedades tensoativas e emulsificantes. Estes compostos são candidatos para substituir os surfatantes sintéticos em aplicações industriais devido à sua menor toxicidade, maior biodegradabilidade, maior diversidade química e maior eficiência e efetividade em condições físicas extremas de salinidade, pressão e temperatura. O uso comercial e industrial dos BS ainda não é sustentável devido a seu alto custo de produção relacionado principalmente ao baixo rendimento. A utilização de substratos de baixo custo e ferramentas estatística

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31

Schulz, Daniel [Verfasser]. "L-Proline and Glutamatergic Neurotransmission : Clarifying the Modulatory Role of Neuronal L-Proline Transporter / Daniel Schulz." Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1044971096/34.

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32

Lawrence, Christopher C. "Studies on bacterial proline 4-hydroxylase." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358610.

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33

Hu, Chien-an Andy. "Osmoregulation and proline biosynthesis in plants /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487843688956923.

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34

Espinosa, Zuleima Del Carmen Caballero. "Origem, evolução e relações filogenéticas de homólogos de prolina racemase em espécies de Trypanosoma." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-24022015-162835/.

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Os genes de Prolina racemase (PRACs) são enzimas intracelulares ou secretadas de T. cruzi (TcPRAC); essas enzimas estão envolvidas no metabolismo, diferenciação e virulência. Os genes PRAC foram identificados e caracterizados molecularmente em isolados representantes de toda a diversidade interespecífica de T. cruzi, T. cruzi marinkellei, T. dionisii, T. erneyi, T. rangeli, T. conorhini e T. lewisi. Além dessas espécies de tripanossomas restritas a mamíferos; homólogos de PRAC foram encontrados em tripanossomas de cobra (T. serpentis), crocodilo (T. grayi) e anuro (T. sp. 339). Análises fil

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35

Santos, Júlio Renovato dos. "Caracterização fisiológica de genótipos de cana-de-açúcar e avaliação de seus desempenhos em condições de restrição hídrica." Universidade Federal de Sergipe, 2012. https://ri.ufs.br/handle/riufs/6645.

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Sugarcane is a C4 plant that can be grown in tropical and subtropical regions adapt to different soil types and climatic conditions, especially for its large and broad utility operation, and raw material for various products such as molasses, molasses, sugar and ethanol. However, the production of cane sugar is being affected by poor rainfall distribution and the reduction of presipitation in some regions. Thus, this study aimed to characterize (field capacity) and evaluate the performance of genotypes of sugar cane submitted to water restriction and rehydration, using physiological indicators

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36

Habibi-Najafi, Mohammad B. (Mohammad Bagher). "Proline-specific peptidases from Lactobacillus casei subspecies." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28455.

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The objectives of this study were (l) to screen out active proline-specific peptidases from Lactobacillus casei subspecies, (2) to study growth kinetic and enzyme production from enriched medium (MRS) and cheese whey medium, (3) to purify and characterize two active proline-specific enzymes, and (4) to investigate the action of purified enzyme on bitter tryptic digests of $ beta$-casein as well as bitter enzyme-modified cheese. Lactobacillus casei subsp. casei LLG and Lactobacillus casei subsp. rhamnosus S93 were examined for extra- and intra-cellular proline-specific peptidase activities. Bot

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37

Walters, Nicola Jane. "Arginine and proline catabolism in Schizosaccharomyces pombe." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257192.

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38

Robinson, Kenneth J. "Bio-organic studies on proline 4-hydroxylase." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320660.

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39

Jones, Iwan Gwynedd. "Desymmetrization of meso-anhydrides by proline esters." Thesis, Bangor University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265515.

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40

Daly, D. J. "Post-proline cleaving enzymes in skeletal muscle." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304040.

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D'Rozario, Robert S. G. "Conformational dynamics of proline-containing transmembrane helices." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670181.

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UEDA, Akihiro, Weiming SHI, Takiko SHIMADA, Hiroshi MIYAKE, and Tetsuko TAKABE. "Altered expression of barley proline transporter causes different growth responses in Arabidopsis." Springer, 2007. http://hdl.handle.net/2237/8780.

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Eriksen, Heidi Sofie. "The synthesis and use of polymer supported Î² amino sulfur containing catalysts." Thesis, University of Strathclyde, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248596.

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White, Tommi Anna. "Structural and functional studies of proline catabolic enzymes." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4760.

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Thesis (Ph.D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on March 24, 2009) Vita. Includes bibliographical references.

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Nguyen, Thi-Huong. "Synthèse de nouveaux catalyseurs chiraux à base de la L-proline. Applications en catalyse asymétrique." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112382.

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Depuis de nombreuses années, les phosphines chirales multifonctionnelles se sont révélées être des outils synthétiques puissants en organocatalyse asymétrique. Ces catalyseurs qui contiennent un site de base de Lewis et un site d'acide de Bronsted, ont reçu une attention particulière en raison de leur efficacité pour créer des liaisons C-C avec de très bonnes énantiosélectivités. A notre connaissance, la synthèse d'organocatalyseurs de type thiourée-phosphine dérivés de la (L)-proline n'a jamais été décrite dans la littérature. Ce sujet de thèse concerne la synthèse d'une nouvelle famille d'or

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Huy, Peter [Verfasser]. "Stereoselektive Synthese von Prolin-Prolin-Dipeptidmimetika / Peter Huy." München : Verlag Dr. Hut, 2011. http://d-nb.info/1011441632/34.

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Dikic, Inga. "Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5316-3/.

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Norris, Simon Richard. "Studies towards the synthesis of useful proline derivatives." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315897.

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Bess, Kirstin. "Transcriptional repression by the proline rich homeodomain protein." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390994.

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Omar, Muhiadin. "Biotransformations of proline by 2-oxoglutarate-dependent hydroxylases." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/19532/.

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Hydroxylases introduce hydroxyl groups with excellent regio- and enantioselectivity making them of significant interest for use in the production of pharmaceutical intermediates and drug metabolites. 2-oxoglutarate dependent oxygenases (2OGDOs) are non-haem dependent Fe(II) containing enzymes that catalyse various oxidation reactions, including the hydroxylation of free amino acids. Unlike the more studied cytochromes P450, these enzymes only require molecular oxygen, Fe(II) and 2-oxoglutarate for catalysis, circumventing the need for a costly cofactor regeneration system. The targets of this

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