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Dissertations / Theses on the topic 'Protein titration'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Rabenstein, Björn. "Monte Carlo methods for simulation of protein folding and titration." [S.l. : s.n.], 2000. http://www.diss.fu-berlin.de/2000/124/index.html.

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2

Walker, Karen Nicola. "Protein engineering and characterisation of an IgG-binding domain based upon protein G from Streptococcus group G." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296376.

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3

Marklund, Erik. "Gas-Phase Protein Structure Under the Computational Microscope : Hydration, Titration, and Temperature." Doctoral thesis, Uppsala universitet, Beräknings- och systembiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151006.

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Although the native environment of the vast majority of proteins is a complex aqueous solution, like the interior of a cell, many analysis methods for assessing chemical and physical properties of biomolecules require the sample to be aerosolized; that is, transferred to the gas-phase. An important example is electrospray-ionization mass spectrometry, which can provide a wide range of information about e.g. biomolecules. That includes structural features, charged sites, and gas-phase equilibrium constants of reactions. To date much of the microscopic detail about the aerosolization process rem

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4

Wahlberg, Elisabet. "Structure determination and thermodynamic stabilization of an engineered protein-protein complex." Doctoral thesis, KTH, Skolan för bioteknologi (BIO), 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4230.

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The interaction between two 6 kDa proteins has been investigated. The studied complex of micromolar affinity (Kd) consists of the Z domain derived from staphylococcal protein A and the related protein ZSPA-1, belonging to a group of binding proteins denoted affibody molecules generated via combinatorial engineering of the Z domain. Affibody-target protein complexes are good model systems for structural and thermodynamic studies of protein-protein interactions. With the Z:ZSPA-1 pair as a starting point, we determined the solution structure of the complex and carried out a preliminary character

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5

Papadopoulou, Athina. "The application of capillary electrophoresis, isothermal titration calorimetry and fluorescence spectroscopy for the study of protein-polyphenol interactions." Thesis, University of Reading, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430942.

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6

Fleischer, Candace C. "A molecular snapshot of charged nanoparticles in the cellular environment." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53632.

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Nanoparticles are promising platforms for biomedical applications ranging from diagnostic tools to therapeutic delivery agents. During the course of these applications, nanoparticles are exposed to a complex mixture of extracellular serum proteins that nonspecifically adsorb onto the surface. The resulting protein layer, or protein "corona," creates an interface between nanoparticles and the biological environment. Protecting the nanoparticle surface can reduce protein adsorption, but complete inhibition remains a challenge. As a result, the corona, rather than the nanoparticle itself, mediate

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Dewan, Nitika. "Elucidation of Thermodynamic Parameters for a Host Cell Protein Acting on a HIV-1 Splicing Regulatory Element." Miami University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=miami1323022700.

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8

Gava, Lisandra Marques 1982. "Caracterização e interação do domínio C-terminal da chaperona Hsp90 humana e das co-chaperonas Tom 70 e Hop." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314027.

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Orientador: Carlos Henrique Inácio Ramos<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-18T21:37:15Z (GMT). No. of bitstreams: 1 Gava_LisandraMarques_D.pdf: 9573403 bytes, checksum: 4d69a29d08ffc20e4544b876f131fb0d (MD5) Previous issue date: 2011<br>Resumo: A função biológica das proteínas está relacionada à sua estrutura tridimensional adquirida pelo processo de enovelamento protéico. Neste contexto, proteínas denominadas, genericamente, de chaperonas moleculares exercem papel fundamental atuando no auxílio do enovelamen

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9

Xu, Shenyuan. "Nuclear Magnetic Resonance Spectroscopy Studies of At2g44920, a Pentapeptide Repeat Protein from Arabidopsis thaliana and X-ray Crystallography, Isothermal Titration Calorimetry Studies of K-Ras, a Human Oncogenic GTP-ase Signaling Protein." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1500896385881469.

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10

Dong, Jian. "Photochemical and Photophysical Studies of Synthetic Derivatives of the Green Fluorescent Protein Chromophore." Diss., Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24655.

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We have synthesized dimethyl derivatives of the GFP chromophore (p-HOBDI) and several of its derivatives, and their photochemistry and photophysics were investigated using various steady-state and time-resolved techniques as follows. We first consider the effect of the £]-barrel on the optical properties of the GFP chromophore (p-HOBDI) experimentally by selective variation of the protonation state of chromophores and different solvents. Each of these forms shows a complex solvatochromic behavior and is governed by both polar and acid/base properties of the solvents. In contrast to their sol

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11

Yu, Shun. "Protein interaction with polyelectrolytes and ligands: A structural and thermodynamic investigation." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18197.

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Der erste Teil dieser Arbeit untersucht die Ladungswechselwirkung zwischen Proteinen und Polyelektrolyten. Dabei wird die Bindung von Polyakrylsäure (PAA) als kurzes Modell-Polyelektrolyt an Humanalbumin (HSA) in einer umfassenden experimentellen und theoretischen Studie untersucht und sehr gute Übereinstimmung der Resultate konnte festgestellt werden. Die Computersimulationen in dieser Arbeit wurden von Xiao Xu im Rahmen seiner Promotion durchgeführt. Thermodynamische Daten wurden mit Hilfe von Isothermer Titrationskalorimetrie (ITC) gesammelt und strukturelle Untersuchungen wurden mit Hilfe

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12

Rouka, Evgenia. "Investigation of binding preferences and identification of novel binding partners for the SH3 domains of the multifunctional adaptor protein CD2AP." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:2eb39788-1916-4995-bd2c-b910d06a5a9b.

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CD2AP is a member of the CD2AP/CIN85 family of adaptors and involved in several cellular processes, such as kidney podocyte development, actin mediated membrane trafficking and T cell activation. It contains three SH3 domains whose binding properties and interaction partners remain largely unexplored. The CD2AP SH3 interaction with the novel partner Rab5-activating GEF RIN3 was studied extensively by isothermal titration calorimetry (ITC), peptide scanning arrays, mutagenesis and X-ray crystallography. Mapping of the interaction regions showed that human RIN3 contains two binding sites for the

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13

Lindberg, Mikael. "Protein folding studies of human superoxide dismutase and ALS associated mutants." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-305.

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14

Trivella, Daniela Barretto Barbosa. "Bases moleculares e estruturais do reconhecimento de ligantes pela proteína transtirretina humana." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-28092010-095827/.

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Mais de quarenta proteínas humanas estão envolvidas em doenças amilóides, sendo a transtirretina (TTR) uma dessas. A dissociação do tetrâmero da TTR é a etapa limitante para sua via de agregação. Esta etapa pode ser dificultada pela ligação de pequenas moléculas a dois sítios na interface tetramérica da TTR e facilitada em variantes mutantes. A mutante V30M é a variante amiloidogênica mais frequente da TTR e, apesar da mutação não se encontrar no sítio de ligação de pequenas moléculas, pode limitar a interação de inibidores com esta proteína. Desta forma, a busca de inibidores da agregação da

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15

McGuire, Kelly Lewis. "Governing Dynamics of Divalent Copper Binding by Influenza A Matrix Protein 2 His37 Imidazole." BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/8647.

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Influenza A is involved in hundreds of thousands of deaths globally every year resulting from viral infection-related complications. Previous efforts to subdue the virus by preventing proper function of wild-type (WT) neuraminidase (N), and M2 proteins using oseltamivir and amantadine (AMT) or rimantadine (RMT), respectively, exhibited success initially. Over time, these drugs began exhibiting mixed success as the virus developed drug resistance. M2 is a proton channel responsible for the acidification of the viral interior which facilitates release of the viral RNA into the host. M2 has a His

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16

Boström, Fredrik. "Single-cycle kinetics for QCM biosensors for high throughput nanoparticle characterization application." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-298942.

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Characterizing nanoparticles to be able to understand how they functions in the body is important for development of drugs. Furthermore with increasing number of nanoparticle product the nanotoxicity of nanoparticles is important to understand. This report is a part of the EU-project Nanoclassifier which purpose is to “develop a cost effective, high throughput screening platform for characterization of the bionanointerface and its cell-binding partners”. Single-cycle kinetic was used to determine the number of binding epitopes on polystyrene nanoparticle with transferrin corona. The number of

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17

Thompson, Kayla Dawn. "Structural Characterization of β-Lactoglobulin in Sodium Dodecyl Sulfate and Lauryldimethylamine Oxide". Miami University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=miami1604698714328977.

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18

Zhang, Jin. "Macromolecular Interactions in West Nile Virus RNA-TIAR Protein Complexes and of Membrane Associated Kv Channel Peptides." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/chemistry_diss/81.

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Macromolecular interactions play very important roles in regulation of all levels of biological processes. Aberrant macromolecular interactions often result in diseases. By applying a combination of spectroscopy, calorimetry, computation and other techniques, the protein-protein interactions in the system of the Shaw2 Kv channel and the protein-RNA interactions in West Nile virus RNA-cellular protein TIAR complex were explored. In the former system, the results shed light on the local structures of the key channel components and their potential interaction mediated by butanol, a general anesth

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19

Badillo, Aurélie. "Analyses structurales et fonctionnelles de la protéine non-structurale 5A (NS5A) du virus de l’hépatite C." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10239.

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La protéine NS5A est essentielle pour la réplication et l'assemblage du virus de l'hépatite C (VHC), et elle constitue une cible thérapeutique prometteuse pour le développement d'antiviraux. Cependant, aucune fonction claire n'a encore été décrite pour NS5A, et les connaissances structurales restent limitées. Ainsi, nous avons caractérisé l'état intrinsèquement désordonné des domaines D2 et D3 de NS5A en décrivant leurs espaces conformationnels et leurs potentialités de repliement en combinant différentes méthodes biophysiques. Nous avons aussi mis en évidence la variabilité structurale du dom

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20

Baird, Sharon. "A study of type-3 copper proteins from arthropods." Thesis, University of Stirling, 2007. http://hdl.handle.net/1893/266.

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Arthropod hemocyanin and phenoloxidase are members of a group of proteins called the Type-3 copper oxygen-binding proteins, both possessing a highly conserved oxygen-binding site containing two copper atoms each coordinated by three histidine residues (Decker and Tuczek, 2000). Despite similarities in their active site, these proteins have very different physiological functions. Phenoloxidase possesses both tyrosinase and o-diphenoloxidase activity, and is predominantly involved in reactions which protect insects from infection (Kopàcek et al., 1995). Hemocyanin is a large multi-subunit protei

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21

Filho, Pedro Leonidas Oseliero. "Caracterização estrutural de sistemas biológicos de diferentes classes: um estudo pela técnica de SAXS." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/43/43134/tde-03022019-183354/.

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Esta tese apresenta resultados da caracterização estrutural de três sistemas de classes diferentes por meio, principalmente, da modelagem de dados de espalhamento de raios X a baixos ângulos (SAXS). No sistema surfactante-surfactante as micelas mistas são formadas por dodecil sulfato de sódio (SDS) e um dos surfactantes da série Tween (Tween 20, 40, 60 e 80). A modelagem adotada impôs vínculos moleculares uma vez que os dados de SAXS estavam em escala absoluta. Isso reduziu a ambiguidade nos valores dos parâmetros ajustáveis e permitiu verificar que os dados de SAXS são satisfatoriamente descr

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Budukh, Parag P. "Application of isothermal titration calorimetry to the determination of functional stability of proteins in solution /." Full text available from ProQuest UM Digital Dissertations, 2006. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1410676511&SrchMode=1&sid=4&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1218548208&clientId=22256.

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23

Darby, Samuel James. "An isothermal titration calorimetry study : complex binding isotherms obtained from the interaction between phytate and tannins with proteins." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/13841/.

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In a single Isothermal Titration Calorimetry (ITC) experiment, the Gibbs free energy (∆G), the enthalpy (∆H), entropy (∆S), specific heat capacity (ΔCp) and stoichiometry of binding (n) can be identified. Non-sigmoidal binding isotherms are particularly difficult to interpret, yet these are routinely found in ITC studies. ITC binding studies at 25 °C between tannins and bovine serum albumin (BSA) produced biphasic binding isotherms that were suggested to be indicators of positive cooperative binding. However, reducing the temperature to 10 °C produced monophasic binding isotherms, which raised

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24

Lai-Thi, Thanh-Lan. "Propriétés physico-chimiques et structurales de deux hémoprotéines de cyanobactérie thermophile." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112187/document.

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La photosynthèse permet de convertir l’énergie solaire en énergie chimique. Ce processus met en jeu un grand nombre de protéines et complexes protéiques. Le premier complexe de la chaîne photosynthétique est le photosystème II où a lieu l’oxydation de l’eau. Le PSII est composé des protéines D1 et D2. Chez la cyanobactérie thermophile Thermosynechococcus elongatus, il y a trois gènes qui codent trois protéines D1 différentes. La première partie de la thèse décrit le développement d’outils protéomiques basés sur les gels d’électrophorèse 2D pour étudier le protéome des trois différents variants

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25

Bohunská, Miroslava. "Studium interakcí tenzidové složky přípravku Septonex s vybranými proteiny." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-449410.

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The study of protein and surfactant interactions is of great significance in a number of applications, such as the cosmetic, food or pharmaceutical industries and many others. However, they require further study due to their compositional complexity and the limitations of current analytical approaches. In this thesis, the cationic surfactant septonex in combination with two differently charged proteins lysozyme and bovine serum albumin under different physiological conditions (temperature, surfactant concentration, environment and others) was selected to study the interactions. Characterizatio

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Blissing, Annica. "Thiopurine S-methyltransferase - characterization of variants and ligand binding." Licentiate thesis, Linköpings universitet, Kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-136558.

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Thiopurine S-methyltransferase (TPMT) belongs to the Class I S-adenosylmethionine-dependent methyltransferase (SAM-MT) super family of structurally related proteins. Common to the members of this large protein family is the catalysis of methylation reactions using S-adenosylmethionine (SAM) as a methyl group donor, although SAM-MTs act on a wide range of different substrates and carry out numerous biologically important functions. While the natural function of TPMT is unknown, this enzyme is involved in the metabolism of thiopurines, a class of pharmaceutical substances administered in treatme

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27

Pham, Khoa Ngoc. "Conformational Dynamics and Stability Associated with Magnesium or Calcium Binding to DREAM in the Regulation of Interactions between DREAM and DNA or Presenilins." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2589.

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Downstream regulatory element antagonist modulator (DREAM) is involved in various interactions with targets both inside and outside of the nucleus. In the cytoplasm, DREAM interacts with the C-terminal fragments of presenilins to facilitate the production of β-amyloid plaques in Alzheimer’s disease. In the nucleus, Ca2+ free DREAM directly binds to specific downstream regulatory elements of prodynorphin/c-fos gene to repress the gene transcription in pain modulation. These interactions are regulated by Ca2+ and/or Mg2+ association at the EF-hands in DREAM. Therefore, understanding the conforma

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28

Yeh, Chia-Ni, and 葉佳妮. "Development of Baculovirus Titration Method Based on Regulable Expression of Green Fluorescent Protein." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/26317955975882578967.

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29

Rabenstein, Björn [Verfasser]. "Monte Carlo methods for simulation of protein folding and titration / vorgelegt von Björn Rabenstein." 2000. http://d-nb.info/961937408/34.

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30

Clifton, Benjamin Edward. "Functional Evolution of Solute-Binding Proteins." Phd thesis, 2017. http://hdl.handle.net/1885/117185.

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Solute-binding proteins (SBPs) comprise an abundant and adaptable superfamily of extracytoplasmic solute receptors involved in nutrient uptake and chemotaxis, and constitute an important component of the nutrient-scavenging arsenal in bacteria. The SBP superfamily exemplifies the power of evolution to generate functional diversity by tinkering with an existing protein fold; SBPs have evolved to recognise a wide variety of solutes with high affinity and specificity, and have also been co-opted into roles in signal transduction, transcriptional regulation and catalysis. However, the historical s

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31

Lafrance-Vanasse, Julien. "Caractérisation structurale et fonctionnelle des interactions impliquant TFIIH et la machinerie de réparation de l’ADN." Thèse, 2011. http://hdl.handle.net/1866/5953.

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La réparation de l’ADN par excision des nucléotides (NER) est un mécanisme capable de retirer une large variété de lésions causant une distorsion de la double hélice, comme celles causées par les rayons ultraviolets (UV). Comme toutes les voies de réparation de l’ADN, la NER contribue à la prévention de la carcinogénèse en prévenant la mutation de l’ADN. Lors de ce processus, il y a d’abord reconnaissance de la lésion par la protéine XPC/Rad4 (humain/levure) qui recrute ensuite TFIIH. Ce complexe déroule l’ADN par son activité hélicase et recrute l’endonucléase XPG/Rad2 ainsi que d’autres prot

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32

Murmiliuk, Anastasiia. "Multidimenzionální charakterizace polyelektrolytů a interpolyelektrolytových komplexů ve vodných roztocích." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-438407.

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Multidimensional characterization of polyelectrolytes and interpolyelectrolyte complexes in aqueous solutions Abstract: This PhD thesis is dedicated to the study of polyelectrolytes and their self-assembly in aqueous solutions. The morphology and ionization state of individual polymer chains were investigated as well as their co-assembly with oppositely charged species. First, the charge regulation of short and long weak polyelectrolytes in aqueous solution was investigated to deeper understand their pH-responsive properties. The changes of ionization degree and charge of oligopeptides compose

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Hsu, Chao-Hsiang, and 許朝翔. "Isothermal Titration Calorimetric Studies of the Non-fouling Interaction Mechanism Between Proteins and Polyethyleneglycol." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/32915936669573110926.

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碩士<br>國立中央大學<br>化學工程與材料工程研究所<br>95<br>The characteristics of preventing nonspecific adsorption of protein has lead to extensive usage of PEG and its derivatives for biomedical applications. We consider that the interaction of water with the PEG is a major determinant of preventing protein adsorption. However, the thermodynamics aspect of the mechanism has not been well addressed. Therefore, in this study, we described the hydration behavior of PEG by measuring the dilution heat of PEG with various salt concentration, types of salt ions, temperature and molecular weight of PEG. In addition, we

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Idrissa, Moussa Mohamed. "Études structurales d’interactions protéine/protéine impliquées dans la leucopoïèse." Thèse, 2017. http://hdl.handle.net/1866/18660.

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La génération des cellules hématopoïétiques, aussi connue sous le nom d'hématopoïèse, est contrôlée par l’activité conjuguée de facteurs de transcription lignée-spécifiques permettant l’expression, en temps et lieu, de gènes spécifiques nécessaires pour le développement cellulaire. Dans le cadre de notre étude, nous avons étudié les facteurs de transcription KLF2 et KLF4 qui jouent des rôles cruciaux dans la formation des lymphocytes B et T. KLF2 et KLF4 activent la transcription de gènes spécifiques via leur interaction avec le co-activateur (CBP). Leurs interactions avec CBP requièrent le do

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R, Chabot Philippe. "Caractérisation structurale et fonctionnelle des interactions impliquant TFIIH et les domaines de transactivation viraux." Thèse, 2014. http://hdl.handle.net/1866/11003.

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Le facteur de transcription IIH (TFIIH) joue un rôle crucial dans la transcription et dans la réparation de l’ADN. La sous-unité Tfb1/p62 (levure et humain) de TFIIH interagit avec de nombreux facteurs de transcription (p53, NFκB, TFIIEα) et de réparation (Rad2/XPG and Rad4/XPC) (1). La majorité des interactions avec Tfb1/p62 requiert le domaine d’homologie à la Pleckstrin (PH) localisé dans la région N-terminal de la protéine (2, 3). Ce domaine PH forme des complexes avec des domaines de transactivation acide provenant de protéines cibles impliquées dans la transcription et la réparatio

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36

Dobrev, Plamen. "Protonation patterns in reduced and oxidized form of electron transfer proteins." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0C2-8.

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Cordeiro, Raquel Sofia Correia. "Structural and functional characterization of ModA and TupA proteins belonging to the molybdate and tungstate transport system from desulfovibrio alaskensis G20." Master's thesis, 2014. http://hdl.handle.net/10362/13944.

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38

Waszczuk, Małgorzata. "Syntetyczne analogi trimetyloguanozyno kapu modyfikowane w mostku trifosforanowym jako narzędzia do badania snurportyny i optymalizacji sygnału transportu dojądrowego dla czynników terapeutycznych." Doctoral thesis, 2017. https://depotuw.ceon.pl/handle/item/2426.

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Trimetyloguanozyno (TMG) kap wystepuje na 5’ koncu małych jadrowych RNA (sn RNA) u organizmów wyzszych. Jego główna funkcja jest transport małych jadrowych rybonukleoprotein (snRNP) do jadra komórkowego poprzez oddziaływanie z białkiem adaptorowym – snurportyna1. Struktura TMG kapu zbudowana jest z N2,N2,N7-trimetyloguanozyny połaczonej mostkiem 5’,5’-trifosforanowym z pierwszym nukleozydem łancucha RNA. Głównym celem badan zawartych w niniejszej rozprawie doktorskiej, było opracowanie metod syntezy chemicznej analogów kapu, posiadajacych rózne modyfikacje w obrebie mostka 5’,5’- trifosforanow

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Cieplak-Rotowska, Maja. "Biophysical and molecular biology studies of proteins involved in gene silencing." Doctoral thesis, 2017. https://depotuw.ceon.pl/handle/item/2368.

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This thesis provides biophysical bases of the interactions between two proteins involved in microRNA (miRNA)-mediated silencing: CNOT1 and the silencing domain of GW182. The regulation of gene expression at the post-transcriptional level involves the crucial CCR4-NOT deadenylase complex, which deadenylates mRNA, and can also inhibit translation in an independent fashion. In miRNA-mediated silencing, the CCR4-NOT complex is brought into the vicinity of the target mRNA by the successive actions of the miRNA, the Argonaute protein and finally, the GW182 protein, which interacts directly with CCR4

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