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Journal articles on the topic 'PRPA'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Shi, Liang, David G. Kehres, and Michael E. Maguire. "The PPP-Family Protein Phosphatases PrpA and PrpB of Salmonella enterica Serovar Typhimurium Possess Distinct Biochemical Properties." Journal of Bacteriology 183, no. 24 (2001): 7053–57. http://dx.doi.org/10.1128/jb.183.24.7053-7057.2001.

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ABSTRACT Salmonella enterica serovar Typhimurium requires Mn2+, but only a few Mn2+-dependent enzymes have been identified from bacteria. To characterize Mn2+-dependent enzymes from serovar Typhimurium, two putative PPP-family protein phosphatase genes were cloned from serovar Typhimurium and named prpA and prpB. Their DNA-derived amino acid sequences showed 61% identity to the corresponding Escherichia coli proteins and 41% identity to each other. Each phosphatase was expressed in E. coliand purified to near electrophoretic homogeneity. Both PrpA and PrpB absolutely required a divalent metal

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Compadre, Amanda J., Carmen Sandoval, Olivia Graham, et al. "Abstract B094: A combined RAD51 and phosphorylated replication protein assay predict response to platinum chemotherapy in high-grade serous ovarian cancer." Cancer Research 84, no. 5_Supplement_2 (2024): B094. http://dx.doi.org/10.1158/1538-7445.ovarian23-b094.

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Abstract Introduction: An effective assay is needed to predict response to platinum chemotherapy in high-grade serous ovarian cancer (HGSOC). We previously showed that patients with RAD51-Low (functionally deficient HR) tumors responded better to platinum chemotherapy than patients with RAD51-High tumors (RR 5.28, P&lt;0.001). This RAD51 foci assay predicted platinum sensitivity with 100% specificity and 100% positive predictive value, but it had 40% sensitivity due to some RAD51-High tumors also being platinum sensitive. To improve the assay, we evaluated whether phosphorylated replicatio

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Ni, Songwei, Baiyuan Li, Kaihao Tang, et al. "Conjugative plasmid-encoded toxin–antitoxin system PrpT/PrpA directly controls plasmid copy number." Proceedings of the National Academy of Sciences 118, no. 4 (2021): e2011577118. http://dx.doi.org/10.1073/pnas.2011577118.

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Toxin–antitoxin (TA) loci were initially identified on conjugative plasmids, and one function of plasmid-encoded TA systems is to stabilize plasmids or increase plasmid competition via postsegregational killing. Here, we discovered that the type II TA system, Pseudoalteromonas rubra plasmid toxin–antitoxin PrpT/PrpA, on a low-copy-number conjugative plasmid, directly controls plasmid replication. Toxin PrpT resembles ParE of plasmid RK2 while antitoxin PrpA (PF03693) shares no similarity with previously characterized antitoxins. Surprisingly, deleting this prpA-prpT operon from the plasmid doe

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GURTLER, JOSHUA B., and TONY Z. JIN. "Propylparaben Sensitizes Heat-Resistant Salmonella Enteritidis and Salmonella Oranienburg to Thermal Inactivation in Liquid Egg Albumen†." Journal of Food Protection 75, no. 3 (2012): 443–48. http://dx.doi.org/10.4315/0362-028x.jfp-11-158.

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Propyl p-hydroxybenzoic acid (propylparaben [PRPA]) is a phenolic antioxidant, known to occur in nature and used as a microbiostat in foods, feeds, pharmaceuticals, cosmetics, and medications. The U.S. Department of Agriculture, Food Safety and Inspection Service (FSIS) requires that liquid egg white (LEW) be pasteurized at 56.7°C for 3.5 min. This study evaluated the effects of PRPA on the pasteurization sensitivity of Salmonella in LEW. When LEW (pH 7.8) was pasteurized under FSIS conditions, salmonellae declined by 0.5, 4.6, 4.5, &gt;7.0, and &gt;7.0 log CFU/ml, with 0, 125, 250, 50

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Yang, Tzong-Hann, Sudha Xirasagar, Yen-Fu Cheng, Chuan-Song Wu, Yi-Wei Kao, and Herng-Ching Lin. "A Nationwide Population-Based Study on the Incidence of Parapharyngeal and Retropharyngeal Abscess—A 10-Year Study." International Journal of Environmental Research and Public Health 18, no. 3 (2021): 1049. http://dx.doi.org/10.3390/ijerph18031049.

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This study aimed to investigate the annual incidence of parapharyngeal and retropharyngeal abscess (PRPA) based on 10-year population-based data. Patients with PRPA were identified from the Taiwan Health Insurance Research Database, a database of all medical claims of a randomly selected, population-representative sample of over two million enrollees of the National Health Insurance system that covers over 99% of Taiwan’s citizens. During 2007–2016, 5779 patients received a diagnosis of PRPA. We calculated the population-wide incidence rates of PRPA by sex and age group (20–44, 45–64, and >

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Li, Baoguang, Eric W. Brown, Christine D'Agostino, J. Eugene LeClerc, and Thomas A. Cebula. "Structure and distribution of the phosphoprotein phosphatase genes, prpA and prpB, among Shigella subgroups." Microbiology 151, no. 8 (2005): 2671–83. http://dx.doi.org/10.1099/mic.0.27990-0.

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Phosphoprotein phosphatases encoded by the prpA and prpB genes function in signal transduction pathways for degradation of misfolded proteins in the extracytoplasmic compartments of Escherichia coli. In order to trace the evolution of prp genes and assess their roles in other enteric pathogens, the structure and distribution of these genes among closely related Shigella subgroups were studied. PCR amplification, probe hybridization studies and DNA sequencing were used to determine the prp genotypes of 58 strains from the four Shigella subgroups, Dysenteriae, Boydii, Sonnei and Flexneri. It was

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Shuma, Madhabi Lata, Bishyajit Kumar Biswas, Sheikh Zahir Raihan, and Shimul Halder. "In vitro Comparative Dissolution Studies of Different Propranolol Generic Tablets Available in Bangladesh." Journal of Drug Delivery and Therapeutics 11, no. 6-S (2021): 86–91. http://dx.doi.org/10.22270/jddt.v11i6-s.5225.

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The present study focused to assess in vitro dissolution profiles of four different products of propranolol 10 mg Tablets (Randomly coded as PRP1-PRP4) available in Bangladesh comparing with the reference brand (coded as REF). Propranolol is a competitive non selective beta-adrenergic receptor antagonist used to amend or restore normal heart rhythm in cardiovascular diseases. An in vitro dissolution study was carried out using the United States Pharmacopoeia (USP) paddle method at 75 rpm with 500 mL of 0.1N HCl dissolution media at 37.0± 0.5 0C. All the tested locally manufactured propranolol

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Jauro, Solomon, Okechukwu C. Ndumnego, Charlotte Ellis, Angela Buys, Wolfgang Beyer, and Henriette van Heerden. "Immunogenicity of Non-Living Anthrax Vaccine Candidates in Cattle and Protective Efficacy of Immune Sera in A/J Mouse Model Compared to the Sterne Live Spore Vaccine." Pathogens 9, no. 7 (2020): 557. http://dx.doi.org/10.3390/pathogens9070557.

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The Sterne live spore vaccine (SLSV, Bacillus anthracis strain 34F2) is the veterinary vaccine of choice against anthrax though contra-indicated for use with antimicrobials. However, the use of non-living anthrax vaccine (NLAV) candidates can overcome the SLSV limitation. In this study, cattle were vaccinated with either of the NLAV (purified recombinant PA (PrPA) or crude rPA (CrPA) and formaldehyde-inactivated spores (FIS of B. anthracis strain 34F2) and emulsigen-D®/alhydrogel® adjuvants) or SLSV. The immunogenicity of the NLAV and SLSV was assessed and the protective efficacies evaluated u

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9

Nießer, Jacqueline. "Freedom of Culture in and after Yugoslavia. An Interview with Branka Prpa." Südosteuropa 67, no. 1 (2019): 110–28. http://dx.doi.org/10.1515/soeu-2019-0005.

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Abstract The historian Branka Prpa was the director of the Historical Archives of Belgrade after Slobodan Milošević’s regime ended in 2000. Jacqueline Nießer spoke to Prpa about how she set about reforming Belgrade’s Historical Archives during Serbia’s democratic opening-up under Zoran Djindjić. Prpa has fostered preservation of the cultural history of socialist Yugoslavia, so the focus of the interview was cultural freedom in and after Yugoslavia. The historian elaborates on how culture both then and now has been in conflict with politics, her remarks leading on to a discussion about how a fu

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Zhang, Cheng-Cai, Aline Friry, and Ling Peng. "Molecular and Genetic Analysis of Two Closely Linked Genes That Encode, Respectively, a Protein Phosphatase 1/2A/2B Homolog and a Protein Kinase Homolog in the CyanobacteriumAnabaena sp. Strain PCC 7120." Journal of Bacteriology 180, no. 10 (1998): 2616–22. http://dx.doi.org/10.1128/jb.180.10.2616-2622.1998.

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ABSTRACT Reversible protein phosphorylation plays important roles in signal transduction. One gene, prpA, encoding a protein similar to eukaryotic types of phosphoprotein phosphatases PP1, PP2A, and PP2B, was cloned from the nitrogen-fixing cyanobacterium Anabaenasp. strain PCC 7120. Interestingly, a eukaryotic-type protein kinase gene, pknE, was found 301 bp downstream ofprpA. This unusual genetic arrangement provides the opportunity for study about how the balance between protein phosphorylation and dephosphorylation can regulate cellular activities. Both proteins were overproduced in Escher

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11

Golovchin, M. A. "Measuring professional preparedness of would-be teachers for pedagogical activity based on criteria-level estimation." Russian Journal of Economics and Law 17, no. 4 (2023): 882–903. http://dx.doi.org/10.21202/2782-2923.2023.4.882-903.

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Objective: to determine the level of future teachers’ professional readiness for pedagogical activity using the statistical method of analysis based on the secondary data of a sociological research; to assess the factors affecting the above level.Methods: the study applied an index method of generalizing the data of sociological measurements to calculate the index of professional readiness for pedagogical activity (Iprpa). As part of the assessment, we used the data of the sociological survey conducted by VolNTs RAS in May-June 2023 among graduate students majoring in pedagogy at vocational sc

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Horswill, Alexander R., and Jorge C. Escalante-Semerena. "Salmonella typhimurium LT2 Catabolizes Propionate via the 2-Methylcitric Acid Cycle." Journal of Bacteriology 181, no. 18 (1999): 5615–23. http://dx.doi.org/10.1128/jb.181.18.5615-5623.1999.

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ABSTRACT We previously identified the prpBCDE operon, which encodes catabolic functions required for propionate catabolism inSalmonella typhimurium. Results from13C-labeling experiments have identified the route of propionate breakdown and determined the biochemical role of each Prp enzyme in this pathway. The identification of catabolites accumulating in wild-type and mutant strains was consistent with propionate breakdown through the 2-methylcitric acid cycle. Our experiments demonstrate that the α-carbon of propionate is oxidized to yield pyruvate. The reactions are catalyzed by propionyl c

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13

Mas-Expósito, Laia, Virginia Krieger, Juan Antonio Amador-Campos, Rocío Casañas, and Lluís Lalucat-Jo. "Pocket Restorative Practice Approaches to Foster Peer-Based Relationships and Positive Development in Schools." Education Sciences 12, no. 12 (2022): 880. http://dx.doi.org/10.3390/educsci12120880.

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In schools, the implementation of restorative practices is linked to an improvement in school climate, discipline and management of conflict. There are a few systematic reviews about the implementation of pocket restorative practice approaches (PRPA) in schools but they are restricted in terms of practices included, outcomes and study design. Moreover, none of them seem to include evidence-based recommendations for their implementation. We have dealt with such issues by carrying out a systematic review of the effectiveness of PRPA and developing evidence-based practice guidelines. Nineteen stu

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14

Yuliandari, Aisyara, Yeli Hartuti, Dea Yuni Putri Tomahu, and Hartini H. "The Effectiveness of PRP on Reducing Blood Glucose Levels in Diabetic Mice." JURNAL ANALIS LABORATORIUM MEDIK 7, no. 2 (2022): 60–65. http://dx.doi.org/10.51544/jalm.v7i2.3386.

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PRP contains growth factors that have the potential to repair tissue damage, such as pancreatic damage in diabetes mellitus. Pancreas damage in diabetes mellitus is characterized by hyperglycemia. This study aimed to determine the effectiveness of PRP in reducing blood glucose levels in diabetic mice. Male Swiss Webster mice divided into 5 groups (normal group, DM group, PRP1 group, PRP2 group and PRP3 group). The DM, PRP1, PRP2 and PRP3 groups were given streptozotocin 45 mg/kgBW to induce diabetes mellitus. Mice in the PRP1, PRP2, and PRP3 groups that have indicated diabetes mellitus with gl

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15

Spera, Juan M., Diego J. Comerci, and Juan E. Ugalde. "Brucella alters the immune response in a prpA-dependent manner." Microbial Pathogenesis 67-68 (February 2014): 8–13. http://dx.doi.org/10.1016/j.micpath.2014.01.003.

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16

Semighini, Camile P., Marcela Savoldi, Gustavo H. Goldman, and Steven D. Harris. "Functional Characterization of the PutativeAspergillus nidulansPoly(ADP-Ribose) Polymerase Homolog PrpA." Genetics 173, no. 1 (2006): 87–98. http://dx.doi.org/10.1534/genetics.105.053199.

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Seth, Ampadu, Yuanchun Jiang, Samuel Adu Gyamfi, Debrah Emmanuel, and Eric Amankwa. "DEVELOPMENT OF MEASUREMENT SCALE FOR PERSONALIZED RECOMMENDED PRODUCT ACCEPTANCE (PRPA-SCALE)." MALAYSIAN E COMMERCE JOURNAL 6, no. 2 (2022): 76–85. http://dx.doi.org/10.26480/mecj.02.2022.76.85.

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Personalized recommendation (PR) system has been established to enhance consumers experience by suggesting products for consumers. Researches in PR mostly focus on the PR “system” acceptance but not the “actual product” acceptance. Therefore, this research aims to develop an instrument that measures the psychometric indicators of personalized product recommended acceptance. The sample size for the study were made up of (N=521) consumers from various accessible online marketplace in Ghana (jumia, kikuu, tonaton, jiji, amazon, eBay, aliexpress, alibaba, and other platforms) who represent the end

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Dias, D. T., A. N. Medina, M. L. Baesso, and A. C. Bento. "Statistical Design of Experiments: Study of Cross-Linking Process through the Phase-Resolved Photoacoustic Method as a Multivariable Response." Applied Spectroscopy 59, no. 2 (2005): 173–80. http://dx.doi.org/10.1366/0003702053085025.

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This work presents an add-on result of cross-linking using photoacoustic spectroscopy (PAS) phases in a multivariable process using the phase-resolved photoacoustic (PRPA) method. The method is tested to separate contributions from groupings –OH, –CH2–, –CH3, and Si–OH overtones in the range from 700 to 2600 nm. Samples of the copolymers ethylene vinyltrimethoxysilane (EVS) and grafted vinyltrimethoxysilane (VTS) on low-density polyethylene (LDPE) were prepared having concentrations ( C) of 3, 5, and 7% of catalyst and temperatures ( T) of 70, 80, and 90 °C. By considering the condensation rea

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Schwartz, Dirk, Susanne Berger, Eva Heinzelmann, Konstanze Muschko, Kathrin Welzel, and Wolfgang Wohlleben. "Biosynthetic Gene Cluster of the Herbicide Phosphinothricin Tripeptide from Streptomyces viridochromogenes Tü494." Applied and Environmental Microbiology 70, no. 12 (2004): 7093–102. http://dx.doi.org/10.1128/aem.70.12.7093-7102.2004.

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ABSTRACT The antibiotic phosphinothricin tripeptide (PTT) consists of two molecules of l-alanine and one molecule of the unusual amino acid phosphinothricin (PT) which are nonribosomally combined. The bioactive compound PT has bactericidal, fungicidal, and herbicidal properties and possesses a C—P—C bond, which is very rare in natural compounds. Previously uncharacterized flanking and middle regions of the PTT biosynthetic gene cluster from Streptomyces viridochromogenes Tü494 were isolated and sequenced. The boundaries of the gene cluster were identified by gene inactivation studies. Sequenc

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Jauro, Solomon, Okechukwu C. Ndumnego, Charlotte Ellis, Angela Buys, Wolfgang Beyer, and Henriette van Heerden. "Immunogenicity and Protective Efficacy of a Non-Living Anthrax Vaccine versus a Live Spore Vaccine with Simultaneous Penicillin-G Treatment in Cattle." Vaccines 8, no. 4 (2020): 595. http://dx.doi.org/10.3390/vaccines8040595.

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Sterne live spore vaccine (SLSV) is the current veterinary anthrax vaccine of choice. Unlike the non-living anthrax vaccine (NLAV) prototype, SLSV is incompatible with concurrent antibiotics use in an anthrax outbreak scenario. The NLAV candidates used in this study include a crude recombinant protective antigen (CrPA) and a purified recombinant protective antigen (PrPA) complemented by formalin-inactivated spores and Emulsigen-D®/Alhydrogel® adjuvants. Cattle were vaccinated twice (week 0 and 3) with NLAVs plus penicillin-G (Pen-G) treatment and compared to cattle vaccinated twice with SLSV a

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Missiakas, D. "Signal transduction pathways in response to protein misfolding in the extracytoplasmic compartments of E.coli : role of two new phosphoprotein phosphatases PrpA and PrpB." EMBO Journal 16, no. 7 (1997): 1670–85. http://dx.doi.org/10.1093/emboj/16.7.1670.

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Tao, Jin, Dejun Liu, Jincheng Xiong, et al. "MC-PRPA-HLFIA Cascade Detection System for Point-of-Care Testing Pan-Drug-Resistant Genes in Urinary Tract Infection Samples." International Journal of Molecular Sciences 24, no. 7 (2023): 6784. http://dx.doi.org/10.3390/ijms24076784.

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Recently, urinary tract infection (UTI) triggered by bacteria carrying pan-drug-resistant genes, including carbapenem resistance gene blaNDM and blaKPC, colistin resistance gene mcr-1, and tet(X) for tigecycline resistance, have been reported, posing a serious challenge to the treatment of clinical UTI. Therefore, point-of-care (POC) detection of these genes in UTI samples without the need for pre-culturing is urgently needed. Based on PEG 200-enhanced recombinase polymerase amplification (RPA) and a refined Chelex-100 lysis method with HRP-catalyzed lateral flow immunoassay (LFIA), we develop

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Wang, Huaming, and Michael Ward. "Molecular characterization of a PDI-related gene prpA in Aspergillus niger var. awamori." Current Genetics 37, no. 1 (2000): 57–64. http://dx.doi.org/10.1007/s002940050009.

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Monteiro, Adriana Socorro Ferreira, Nelson Luiz Macedo, Luiz Guilherme Scavone Macedo, and Rosilene Fernandes Rocha. "Histomorphometric, radiographic and biomechanical analyses of platelet rich plasma associated with autogenous bone graft." Brazilian Dental Science 17, no. 4 (2014): 53. http://dx.doi.org/10.14295/bds.2014.v17i4.998.

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<p><strong>Objective:</strong> The aim of this study was to evaluate the effectiveness of platelet rich plasma with and without autogenous bone graft in the bone repair of surgical defects in rabbit tibias. <strong>Materials and Methods:</strong> In this research, 25 adult male rabbits were used. Two defects have been performed in each tibia, divided into four groups: control (C = defect naturally left to heal by clot formation), autogenous (A = bone defect + autogenous graft), PRP (PRP = bone defect + PRP) and autogenous + PRP (PRPA = bone defect + autogenous gra

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Montagna, Franco. "Provability in finite subtheories of PA and relative interpretability: a modal investigation." Journal of Symbolic Logic 52, no. 2 (1987): 494–511. http://dx.doi.org/10.2307/2274396.

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By Solovay's theorem [16], the modal logic of provability GL gives a complete description of the propositional schemata involving the provability predicate PrPA(x) for Peano arithmetic PA, which are provable in PA. However, many important aspects of provability cannot be fully expressed in terms of PrPA(x). For this reason, many authors have introduced extensions of GL which take account either of Rosser constructions or of other important metamathematical formulas (see, for example, [5], [6], [14], [16], and [19]). In this paper, we concentrate on the modal logic of the provability predicate

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Rohit, Deepak Nalawade, and Dilip Devkar Bhagwan. "Olaparib an anticancer drug: A review." World Journal of Biology Pharmacy and Health Sciences 7, no. 3 (2021): 329–36. https://doi.org/10.5281/zenodo.5543239.

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Olaparib is an anti-cancer drug which comes under N-acyl piperazines class. The action of olaparib is PRPA inhibition. Drug taken by oral route which shows action in 1 to 3 hrs. after administration. It is FDA approved drug for various cancer treatment such as ovarian cancer, breast cancer, prostatic cancer and pancreatic cancer. Olaparib also useful different mutation conditions such as BRCA1/2 mutation. Olaparib prescribes after the chemotherapy treatment either singly or in combination. In serious and advanced mutation conditions combination therapy used. In this review paper, we put a narr

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Sasaki, Masashi, Kaoru Takegawa, and Yoshio Kimura. "Enzymatic characteristics of an ApaH-like phosphatase, PrpA, and a diadenosine tetraphosphate hydrolase, ApaH, fromMyxococcus xanthus." FEBS Letters 588, no. 18 (2014): 3395–402. http://dx.doi.org/10.1016/j.febslet.2014.07.031.

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Rohit Deepak Nalawade and Bhagwan Dilip Devkar. "Olaparib an anticancer drug: A review." World Journal of Advanced Research and Reviews 11, no. 2 (2021): 329–36. http://dx.doi.org/10.30574/wjarr.2021.11.2.0406.

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Olaparib is an anti-cancer drug which comes under N-acyl piperazines class. The action of olaparib is PRPA inhibition. Drug taken by oral route which shows action in 1 to 3 hrs. after administration. It is FDA approved drug for various cancer treatment such as ovarian cancer, breast cancer, prostatic cancer and pancreatic cancer. Olaparib also useful different mutation conditions such as BRCA1/2 mutation. Olaparib prescribes after the chemotherapy treatment either singly or in combination. In serious and advanced mutation conditions combination therapy used. In this review paper, we put a narr

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Leya, Mwense, Won Kyong Kim, Jeong Sang Cho, et al. "Vaccination of goats with a combinationSalmonellavector expressing fourBrucellaantigens (BLS, PrpA, Omp19, and SOD) confers protection againstBrucella abortusinfection." Journal of Veterinary Science 19, no. 5 (2018): 643. http://dx.doi.org/10.4142/jvs.2018.19.5.643.

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Mičicová, Z., S. Božeková, M. Pajtášová, and D. Ondrušová. "Curing characteristics and rheological properties of bentonite- filled rubber blends." IOP Conference Series: Materials Science and Engineering 1199, no. 1 (2021): 012037. http://dx.doi.org/10.1088/1757-899x/1199/1/012037.

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Abstract The study deals with the examination of the rheological behaviour of rubber blends which were filled with bentonite. The filler - polymer as well as the filler - filler interactions were studied and determined from the frequency sweep and strain sweep rheological measurements. The used natural bentonite was extracted from the locality called Jelsovy Potok. The natural bentonite had a fine fraction with a particle size of 15μm a 45 μm and it was added into rubber blends as a partial replacement of commonly used filler. The rubber blends were characterised on the basis of curing charact

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Mičicová, Zuzana, Slavomíra Božeková, Mariana Pajtášová, and Darina Ondrušová. "Effect of bentonite modified by silane on rubber blends properties." MATEC Web of Conferences 157 (2018): 07006. http://dx.doi.org/10.1051/matecconf/201815707006.

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The presented paper deals with the preparation of bentonite modified by silane and its application into polymer matrix. Natural bentonite was modified with 3-(Trimethoxysilyl) propyl-methacrylate in two different solutions. These two solutions had the same composition (ethanol, water and 3-(Trimethoxysilyl) propyl-methacrylate) but in one solution, pH was modified. These bentonites modified by silane were characterized by Fourier transform infrared spectroscopy. The modified bentonites were mixed into rubber matrix as partial replacement of commonly used filler – carbon black of the N339 type.

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Abovich, N., P. Legrain, and M. Rosbash. "The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding." Molecular and Cellular Biology 10, no. 12 (1990): 6417–25. http://dx.doi.org/10.1128/mcb.10.12.6417-6425.1990.

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PRP6 and PRP9 are two yeast genes involved in pre-mRNA splicing. Incubation at 37 degrees C of strains that carry temperature-sensitive mutations at these loci inhibits splicing, and in vivo experiments suggested that they might be involved in commitment complex formation (P. Legrain and M. Rosbash, Cell 57:573-583, 1989). To examine the specific role that the PRP6 and PRP9 products may play in splicing or pre-mRNA transport to the cytoplasm, we have characterized in vitro splicing and spliceosome assembly in extracts derived from prp6 and prp9 mutant strains. We have also characterized RNAs t

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Abovich, N., P. Legrain, and M. Rosbash. "The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding." Molecular and Cellular Biology 10, no. 12 (1990): 6417–25. http://dx.doi.org/10.1128/mcb.10.12.6417.

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PRP6 and PRP9 are two yeast genes involved in pre-mRNA splicing. Incubation at 37 degrees C of strains that carry temperature-sensitive mutations at these loci inhibits splicing, and in vivo experiments suggested that they might be involved in commitment complex formation (P. Legrain and M. Rosbash, Cell 57:573-583, 1989). To examine the specific role that the PRP6 and PRP9 products may play in splicing or pre-mRNA transport to the cytoplasm, we have characterized in vitro splicing and spliceosome assembly in extracts derived from prp6 and prp9 mutant strains. We have also characterized RNAs t

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Wilson, R. C., and J. B. Cooper. "Characterization of PRP1 and PRP2 from Medicago truncatula." Plant Physiology 105, no. 1 (1994): 445–46. http://dx.doi.org/10.1104/pp.105.1.445.

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Maddock, J. R., E. M. Weidenhammer, C. C. Adams, R. L. Lunz, and J. L. Woolford. "Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes." Genetics 136, no. 3 (1994): 833–47. http://dx.doi.org/10.1093/genetics/136.3.833.

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Abstract The PRP4 gene encodes a protein that is a component of the U4/U6 small nuclear ribonucleoprotein particle and is necessary for both spliceosome assembly and pre-mRNA splicing. To identify genes whose products interact with the PRP4 gene or gene product, we isolated second-site suppressors of temperature-sensitive prp4 mutations. We limited ourselves to suppressors with a distinct phenotype, cold sensitivity, to facilitate analysis of mutants. Ten independent recessive suppressors were obtained that identified four complementation groups, spp41, spp42, spp43 and spp44 (suppressor of pr

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Berarducci, Alessandro. "The interpretability logic of Peano arithmetic." Journal of Symbolic Logic 55, no. 3 (1990): 1059–89. http://dx.doi.org/10.2307/2274474.

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AbstractPA is Peano arithmetic. The formula InterpPA(α, β) is a formalization of the assertion that the theory PA + α interprets the theory PA + β (the variables α and β are intended to range over codes of sentences of PA). We extend Solovay's modal analysis of the formalized provability predicate of PA, PrPA(x), to the case of the formalized interpretability relation InterpPA(x, y). The relevant modal logic, in addition to the usual provability operator ‘□’, has a binary operator ‘⊳’ to be interpreted as the formalized interpretability relation. We give an axiomatization and a decision proced

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Khachaturov, A. A., E. E. Potapov, S. V. Reznichenko, and A. N. Kovaleva. "Influence of iron ore concentrate (magnetite) on the kinetics of butadiene–styrene rubber-based blend curing in the presence of different accelerators." Fine Chemical Technologies 15, no. 5 (2020): 46–53. http://dx.doi.org/10.32362/2410-6593-2020-15-5-46-53.

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Objectives. To investigate the possibility of using a cheaper ingredient, such as magnetite, in the synthesis of rubber compounds based on butadiene–styrene rubber by examining its effect on the process of sulfuric vulcanization of butadiene–styrene rubber in the presence of various accelerators.Methods. The influence of magnetite on the vulcanization kinetics was studied using an Alpha Technologies PRPA 2000 rotorless rheometer. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were performed using a Mettler Toledo TGA/DSC 2 device to evaluate the effect of magnetit

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Foss, Scott. "A MAP to manage palaeontology." Geological Curator 11, no. 7 (2022): 462–68. http://dx.doi.org/10.55468/gc1462.

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Managing palaeontological resources requires the development of a program that fits the needs of science and society. Here, I present a road map to manage palaeontology that should fit any bureaucracy or governing structure. This involves a mission (M) that articu- lates the purpose for managing palaeontological resources. The mission might be simple or complex, but it always must be consistent and attainable. The mission must also be framed in a legal context of authorities (A). Authorities include statutes, laws, written rules, and policy. The primary statute that authorises palaeontology pr

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Grimek, Tracey L., and Jorge C. Escalante-Semerena. "The acnD Genes of Shewenella oneidensis and Vibrio cholerae Encode a New Fe/S-Dependent 2-Methylcitrate Dehydratase Enzyme That Requires prpF Function In Vivo." Journal of Bacteriology 186, no. 2 (2004): 454–62. http://dx.doi.org/10.1128/jb.186.2.454-462.2004.

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ABSTRACT The propionate utilization operons of several bacteria differ from each other in the occurrence of two genes, acnD and prpF, in place of or in addition to the prpD gene encoding an Fe/S-independent 2-methylcitrate dehydratase enzyme. We cloned the acnD and prpF genes from two organisms, Shewanella oneidensis and Vibrio cholerae, and found that, together, the AcnD and PrpF proteins restored the ability of a prpD mutant strain of Salmonella enterica to grow on propionate as a source of carbon and energy. However, neither acnD nor prpF alone was able to substitute for prpD. The AcnD and

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Craddock, Hillary A., Yair Motro, Bar Zilberman, Boris Khalfin, Svetlana Bardenstein, and Jacob Moran-Gilad. "Long-Read Sequencing and Hybrid Assembly for Genomic Analysis of Clinical Brucella melitensis Isolates." Microorganisms 10, no. 3 (2022): 619. http://dx.doi.org/10.3390/microorganisms10030619.

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Brucella melitensis is a key etiological agent of brucellosis and has been increasingly subject to characterization using sequencing methodologies. This study aimed to investigate and compare short-read, long-read, and hybrid assemblies of B. melitensis. Eighteen B. melitensis isolates from Southern Israel were sequenced using Illumina and the Oxford Nanopore (ONP) MinION, and hybrid assemblies were generated with ONP long reads scaffolded on Illumina short reads. Short reads were assembled with INNUca with SPADes, long reads and hybrid with dragonflye. Abricate with the virulence factor datab

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Blanton, S., A. Srinivasan, and B. C. Rymond. "PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels." Molecular and Cellular Biology 12, no. 9 (1992): 3939–47. http://dx.doi.org/10.1128/mcb.12.9.3939-3947.1992.

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An essential pre-mRNA splicing factor, the product of the PRP38 gene, has been genetically identified in a screen of temperature-sensitive mutants of Saccharomyces cerevisiae. Shifting temperature-sensitive prp38 cultures from 23 to 37 degrees C prevents the first cleavage-ligation event in the excision of introns from mRNA precursors. In vitro splicing inactivation and complementation studies suggest that the PRP38-encoded factor functions, at least in part, after stable splicing complex formation. The PRP38 locus contains a 726-bp open reading frame coding for an acidic 28-kDa polypeptide (P

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Blanton, S., A. Srinivasan, and B. C. Rymond. "PRP38 encodes a yeast protein required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels." Molecular and Cellular Biology 12, no. 9 (1992): 3939–47. http://dx.doi.org/10.1128/mcb.12.9.3939.

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An essential pre-mRNA splicing factor, the product of the PRP38 gene, has been genetically identified in a screen of temperature-sensitive mutants of Saccharomyces cerevisiae. Shifting temperature-sensitive prp38 cultures from 23 to 37 degrees C prevents the first cleavage-ligation event in the excision of introns from mRNA precursors. In vitro splicing inactivation and complementation studies suggest that the PRP38-encoded factor functions, at least in part, after stable splicing complex formation. The PRP38 locus contains a 726-bp open reading frame coding for an acidic 28-kDa polypeptide (P

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Huang, Tzu-Ting, Chih-Yuan Chiang, Jayakumar R. Nair, et al. "Abstract 6173: AKT1 prevents aberrant R-loops accumulation via regulating DHX9 and suppresses transcription-replication collision in PARP inhibitor-resistant ovarian cancer." Cancer Research 83, no. 7_Supplement (2023): 6173. http://dx.doi.org/10.1158/1538-7445.am2023-6173.

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Abstract Background: Acquired resistance to PARP inhibitors (PARPis) is a pressing problem in high-grade serous ovarian cancer (HGSC), highlighting the development of novel therapeutic options. To address this unmet need, we conducted high-throughput drug combination screens in PARPi-resistant HGSC cells using ATR inhibitor (ATRi), given that ATR/CHK1 signaling activation is one of the main mechanisms of PARPi resistance. In the screens, PI3K/AKT pathway inhibitors were synergistic with ATRi. Mechanistically, ATR signaling plays a major role in R-loop dynamics and replication stress (RS) respo

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Li, Xiaopeng, and Fuqiu Li. "Reliability Assessment of Space Station Based on Multi-Layer and Multi-Type Risks." Applied Sciences 11, no. 21 (2021): 10258. http://dx.doi.org/10.3390/app112110258.

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A space station is a typical phased-mission system, and assessing its reliability during its configuration is an important engineering action. Traditional methods usually require extensive data to carry out a layered reliability assessment from components to the system. These methods suffer from lack of sufficient test data, and the assessment process becomes very difficult, especially in the early stage of the configuration. This paper proposes a reliability assessment method for the space station configuration mission, using multi-layer and multi-type risks. Firstly, the risk layer and the r

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Banroques, J., and J. N. Abelson. "PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle." Molecular and Cellular Biology 9, no. 9 (1989): 3710–19. http://dx.doi.org/10.1128/mcb.9.9.3710-3719.1989.

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The Saccharomyces cerevisiae prp mutants (prp2 through prp11) are known to be defective in pre-mRNA splicing at nonpermissive temperatures. We have sequenced the PRP4 gene and shown that it encodes a 52-kilodalton protein. We obtained PRP4 protein-specific antibodies and found that they inhibited in vitro pre-mRNA splicing, which confirms the essential role of PRP4 in splicing. Moreover, we found that PRP4 is required early in the spliceosome assembly pathway. Immunoprecipitation experiments with anti-PRP4 antibodies were used to demonstrate that PRP4 is a protein of the U4/U6 small nuclear ri

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Banroques, J., and J. N. Abelson. "PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle." Molecular and Cellular Biology 9, no. 9 (1989): 3710–19. http://dx.doi.org/10.1128/mcb.9.9.3710.

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The Saccharomyces cerevisiae prp mutants (prp2 through prp11) are known to be defective in pre-mRNA splicing at nonpermissive temperatures. We have sequenced the PRP4 gene and shown that it encodes a 52-kilodalton protein. We obtained PRP4 protein-specific antibodies and found that they inhibited in vitro pre-mRNA splicing, which confirms the essential role of PRP4 in splicing. Moreover, we found that PRP4 is required early in the spliceosome assembly pathway. Immunoprecipitation experiments with anti-PRP4 antibodies were used to demonstrate that PRP4 is a protein of the U4/U6 small nuclear ri

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Urushiyama, Seiichi, Tokio Tani, and Yasumi Ohshima. "The Prpl + Gene Required for Pre-mRNA Splicing in Schizosaccharomyces pombe Encodes a Protein That Contains TPR Motifs and Is Similar to Prp6p of Budding Yeast." Genetics 147, no. 1 (1997): 101–15. http://dx.doi.org/10.1093/genetics/147.1.101.

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Abstract The prp (pre-mRNA processing) mutants of the fission yeast Schizosaccharomyces pombe have a defect in pre-mRNA splicing and accumulate mRNA precursors at a restrictive temperature. One of the prp mutants, prp1-4, also has a defect in poly(A)+ RNA transport. The prp1 + gene encodes a protein of 906 amino acid residues that contains 19 repeats of 34 amino acids termed tetratrico peptide repeat (TPR) motifs, which were proposed to mediate protein-protein interactions. The amino acid sequence of Prplp shares 29.6% identity and 50.6% similarity with that of the PRP6 protein of Saccharomyce

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Mazzoni, I. E., H. C. Ledebur, Jr., E. Paramithiotis, and N. Cashman. "Lymphoid signal transduction mechanisms linked to cellular prion protein." Biochemistry and Cell Biology 83, no. 5 (2005): 644–53. http://dx.doi.org/10.1139/o05-058.

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The normal cellular isoform of the prion protein (PrPC) is a glycosylphosphatidylinositol-anchored cell surface protein that is expressed widely, including in lymphoid cells. We compared lectin-induced mitogenesis and selected cell signaling pathways in splenocytes from wild-type BALB/c mice and Zrch Prnp0/0(PrP0/0) mice bred on a BALB/c background for more than 10 generations.3H-thymidine incorporation induced by concanavalin A (Con A) or phytohemagglutinin (PHA) was significantly reduced in PrP0/0splenocytes, most prominently early in activation (24 and 48 h). Con A activation in PrP0/0splen

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Bottner, Claudia A., Henning Schmidt, Sven Vogel, Melanie Michele, and Norbert F. Käufer. "Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe." Current Genetics 48, no. 3 (2005): 151–61. http://dx.doi.org/10.1007/s00294-005-0013-6.

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Brämer, C. O., L. F. Silva, J. G. C. Gomez, H. Priefert, and A. Steinbüchel. "Identification of the 2-Methylcitrate Pathway Involved in the Catabolism of Propionate in the Polyhydroxyalkanoate-Producing Strain Burkholderia sacchari IPT101T and Analysis of a Mutant Accumulating a Copolyester with Higher 3-Hydroxyvalerate Content." Applied and Environmental Microbiology 68, no. 1 (2002): 271–79. http://dx.doi.org/10.1128/aem.68.1.271-279.2002.

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ABSTRACT Burkholderia sacchari IPT101T induced the formation of 2-methylcitrate synthase and 2-methylisocitrate lyase when it was cultivated in the presence of propionic acid. The prp locus of B. sacchari IPT101T is required for utilization of propionic acid as a sole carbon source and is relevant for incorporation of 3-hydroxyvalerate (3HV) into copolyesters, and it was cloned and sequenced. Five genes (prpR, prpB, prpC, acnM, and ORF5) exhibited identity to genes located in the prp loci of other gram-negative bacteria. prpC encodes a 2-methylcitrate synthase with a calculated molecular mass

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