Relevant bibliographies by topics / Pulsatile Release

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Pulsatile Release'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Pulsatile Release"

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Hakim, T. S. "Flow-induced release of EDRF in the pulmonary vasculature: site of release and action." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 1 (1994): H363—H369. http://dx.doi.org/10.1152/ajpheart.1994.267.1.h363.

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Pulsatile flow is thought to lower pulmonary vascular resistance by passive recruitment of capillaries and by active vasodilation. This study was undertaken to investigate the role of endothelium-derived relaxing factor (EDRF) during pulsatile flow in isolated canine left lower lobes pretreated with indomethacin. The lobes were perfused in situ with autologous blood (approximately 500 ml/min) using a nonpulsatile pump (Masterflex) or a pulsatile pump (Harvard). With the occlusion techniques, vascular resistance was partitioned into four segments: arterial (Ra), small arterial (R'a), small veno
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Hussein, Mayssam, and Israa Nathir. "Pulsatile Drug Delivery System Utilizing Innovative Technology." Pakistan Journal of Medical and Health Sciences 16, no. 6 (2022): 601–6. http://dx.doi.org/10.53350/pjmhs22166601.

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Drugs might be released immediately or over time. Pulsatile medication release systems, on the other hand, have been increasing in popularity in recent years. Many medications or therapies could benefit from pulsatile drug release, in which the drug is released rapidly after a predetermined lag time. Pulsatile release systems come in pairs: multi and separate pulse. Rupturable dose forms are a prominent type of single-pulse device. Other methods have a drug-containing centre covered by both a swelling surface and a semi - permeable barrier polymer layer or membrane that is semipermeable but no
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Kundan Rajendra Mahajan, Ashish Prakash Gorle, and Vijay Sanjay Khalane. "Overview on pulsatile drug delivery system." International Journal of Science and Research Archive 5, no. 2 (2022): 110–18. http://dx.doi.org/10.30574/ijsra.2022.5.2.0067.

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Traditionally, drugs are released in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are gaining growing interest. Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal
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Gandhi, Swapnil, Matthew D. Gosse, Yasuhiro Nishii, and Eric Nuxoll. "Barrier-Mediated Pulsatile Release." Journal of Membrane Science 495 (December 2015): 351–60. http://dx.doi.org/10.1016/j.memsci.2015.07.066.

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Nishii, Yasuhiro, Swapnil Gandhi, and Eric Nuxoll. "Glucose-powered pulsatile release." Chemical Engineering Research and Design 106 (February 2016): 298–307. http://dx.doi.org/10.1016/j.cherd.2015.11.024.

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Sungthongjeen, Srisagul, and Satit Puttipipatkhachorn. "Comparison between Ethylcellulose Aqueous Colloidal Dispersion and Ethylcellulose Ethanolic Solution as Rupturable Coating Materials for Pulsatile Release Tablets." Advanced Materials Research 506 (April 2012): 489–92. http://dx.doi.org/10.4028/www.scientific.net/amr.506.489.

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Pulsatile release dosage forms which time of drug release can be determined have shown advantages for various drugs such as chronopharmacological drugs and drugs with high first pass metabolism. The pulsatile release tablets consisting of drug-containing cores coated with inner swelling layer containing a superdisintegrant (croscarmellose sodium (Ac-Di-Sol®)) and outer rupturable layer (ethylcellulose (EC)) were previously developed. In this study, two different types of EC coating membrane, EC ethanolic solution (ECS) versus EC aqueous colloidal dispersion (ECD), were compared. Propranolol HC
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Koshta, Ashok, and Neelesh Malviya. "Formulation and Evaluation of Floating-pulsating Drug Delivery System containing Fixed-dose Combination for Chronotherapy of Hypertension." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1725–32. http://dx.doi.org/10.25258/ijddt.12.4.39.

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This project aims to build a floating, pulsatile hypertension therapy. This work examined the 3-factor, 2-level box-behnken design and optimization technique for the floating pulsatile tablet. The quantity of polyox WSR N12K and polyox WSR205 was chosen to be the independent variable. Drug release, lag time, and swelling index are chosen to function in terms of dependent variables. ANOVA was intended to assess the data statistically, and p-value of 0.05 was regarded to have statistical significance. The tablet containing bisoprolol fumarate (BF) and hydrochlorothiazide (HCTZ) was chosen for pr
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Jiabi, Ouyang, Wang Xingli, Yang Mohui, Tan Yani, Zhang Zhen, and Li Sha. "Preparation and Drug Release Mechanism of Time Controlled Explosive Pulsatile Tablets with Ethylcellulose Coating." Journal of Pharmaceutical and Biomedical Sciences 10, no. 04 (2020): 81–90. https://doi.org/10.5281/zenodo.3903240.

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<em><strong>Core tip:</strong></em> The development of pharmacology in the decade revealed the biological rhythm of the occurrence and development of certain diseases, usually the circadian rhythm. Therefore, chronopharmacological drug delivery is of great significance in the prevention and treatment of diseases having onset rhythm inconvenient to take drug. An easy-to-prepared, time-controlled explosive metoprolol tartaric pulsatile tablet was developed in order to provide patients with timed therapy of effective blood drug concentration at the optimal time. The formulation and process were o
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Cohen, Smadar, and Robert Langer. "Pulsatile Release from Microencapsulated Liposomes." Journal of Liposome Research 4, no. 1 (1994): 349–60. http://dx.doi.org/10.3109/08982109409037049.

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Medlicott, Natalie J., and Ian G. Tucker. "Pulsatile release from subcutaneous implants." Advanced Drug Delivery Reviews 38, no. 2 (1999): 139–49. http://dx.doi.org/10.1016/s0169-409x(99)00013-7.

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Dissertations / Theses on the topic "Pulsatile Release"

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Gandhi, Swapnilkumar J. "Barrier-mediated pulsatile release." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1601.

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Solutes are often most efficiently deployed in discrete pulses, for example in the delivery of herbicides or drugs. Manual application of each pulse can be labor-intensive, automated application of each pulse can be capital intensive, and both are often costly and impractical. Barrier-Mediated Pulsatile Release (BMPR) systems offer a materials-based alternative for automated pulsatile drug delivery, without pumps, power supplies, or complex circuitry. While earlier materials-based approaches such as delayed-release microcapsules are limited to two or three pulses due to the independent nature
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Westerlund, Johanna. "Pulsatile insulin release from single islets of Langerhans." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-494.

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<p>Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. Diabetic patients show an abnormal plasma insulin pattern, but the cause of the disturbance remains to be elucidated. Ithe present thesis the influence of the cytoplasmic calcium concentratio([Ca<sup>2+</sup>]<sub>i</sub>) and cell metabolism on pulsatile insulin release was examined in single islets of Langerhans from <i>ob/ob</i>-mi
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Miller, Jessica. "Pulsatile release of an ionizable drug from microcapsules with electrochemomechanical walls /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488205318508125.

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Zhang, Jin. "Inhibition of pulsatile luteinizing hormone release by atrial natriuretic peptide and brain natriuretic peptide in the ovariectomized rat." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29412.

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Atrial natriuretic peptide (ANP) of atrial myocyte origin, has been shown to play a role in the diuresis, natriuresis, and antagonism of angiotensin and vasopressin. However, it is now apparent that in addition to the production of the peptide in the heart and in its role in fluid and electrolyte homeostasis, it is also produced in the central nervous system participating in the regulation of pituitary hormone secretion. Administration of ANP through both central and peripheral routes has been shown to inhibit secretion of luteinizing hormone (LH) in the gonadectomized rat model. A better unde
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Hoosain, Famida Ghulam. "A dual oral intestinal film for pulsatile release of a mood stabilizing agent in the treatment of schizoaffective disorder." Thesis, 2016. http://hdl.handle.net/10539/21403.

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A thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Doctor of Philosophy Johannesburg, 2016<br>Oral drug delivery is acknowledged by many as the idyllic method of drug delivery due to its versatility and convenience of administration. Nevertheless, the bioavailability of drugs delivered via the oral route remains disputed. Classically, conventional marketed drug delivery systems release drugs in inconstant and unpredictable manners, leading to sub-therapeutic and in some cases toxic drug doses
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Thitinan, Sumalee. "Development of multiple dose platforms for oral drug delivery." Thesis, 2011. http://hdl.handle.net/2152/ETD-UT-2011-12-4529.

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Multiple dose regimens are frequently required to optimize therapy; however, such therapy is frequently undermined by poor patient adherence. In fact, patient adherence is inversely related to the number of doses a patient is asked to take each drug. Consequently, great efforts are under way to develop drug delivery systems that are able to release drugs over an extended time interval; this could offer considerable benefits including reducing administration frequency. This dissertation describes multiple dose platforms designed to deliver a variety of drugs as a single oral administration a
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Books on the topic "Pulsatile Release"

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Symposium on Mechanisms and Biological Significance of Pulsatile Hormone Secretion (1999 : London, England), ed. Mechanisms and biological significance of pulsatile hormone release. Wiley, 2000.

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O'Reilly, Margaret. The development of a plaque assay for insulin and its application to studies of pulsatile insulin release by single pancreatic be ta-cell. The Author], 1991.

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Book chapters on the topic "Pulsatile Release"

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Thitinan, Sumalee, and Jason T. McConville. "Pulsatile Delivery for Controlling Drug Release." In Controlled Release in Oral Drug Delivery. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1004-1_9.

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Bae, You Han, Ick Chan Kwon, and Sung Wan Kim. "Pulsatile Drug Release by Electric Stimulus." In ACS Symposium Series. American Chemical Society, 1994. http://dx.doi.org/10.1021/bk-1994-0545.ch008.

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Pincus, Steven M. "Orderliness of Hormone Release." In Mechanisms and Biological Significance of Pulsatile Hormone Secretion. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470870796.ch6.

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Terasawa, Ei, and Andrea C. Gore. "Regulation of Pulsatile LHRH Release in Primates." In Modes of Action of GnRH and GnRH Analogs. Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2916-2_17.

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Appelt, Christopher W., and Peter W. Sorensen. "Freshwater Fish Release Urinary Pheromones in a Pulsatile Manner." In Advances in Chemical Signals in Vertebrates. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4733-4_20.

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Robinson, Iain C. A. F. "Control of Growth Hormone (GH) Release by GH Secretagogues." In Mechanisms and Biological Significance of Pulsatile Hormone Secretion. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470870796.ch12.

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Akiti, Otute, A. Ganiyu Jimoh, Donald L. Wise, Gilda A. Barabino, Debra J. Trantolo, and Joseph D. Gresser. "Multiphasic or “Pulsatile” Controlled Release System for the Delivery of Vaccines." In Human Biomaterials Applications. Humana Press, 1996. http://dx.doi.org/10.1007/978-1-4757-2487-5_14.

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Okano, Teruo, Ryo Yoshida, Kiyotaka Sakai, and Yasuhisa Sakurai. "Thermo-Responsive Polymeric Hydrogels and Their Application to Pulsatile Drug Release." In Polymer Gels. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5892-3_22.

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Kawabuchi, Minako, Atsushi Watanabe, Masayasu Sugihara, Akihiko Kikuchi, Yasuhisa Sakurai, and Teruo Okano. "The Pulsatile Release System of Macromolecular Drugs from Alginate Gel Beads." In Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems. Springer Japan, 1996. http://dx.doi.org/10.1007/978-4-431-65883-2_106.

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Veldhuis, Johannes D. "Nature of Altered Pulsatile Hormone Release and Neuroendocrine Network Signalling in Human Ageing: Clinical Studies of the Somatotropic, Gonadotropic, Corticotropic and Insulin Axes." In Mechanisms and Biological Significance of Pulsatile Hormone Secretion. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470870796.ch10.

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Conference papers on the topic "Pulsatile Release"

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Divetia, Asheesh, Nolan Yoshimura, Guann-Pynn Li, Baruch D. Kuppermann, and Mark Bachman. "Controlled and Programmable Drug Delivery Using a Self-Powered MEMS Device." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38054.

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Controlled and targeted drug delivery systems have gained a lot of interest as they offer numerous benefits such as precise dosing, reduced side-effects and increased patient compliance. We have designed a microelectromechanical systems (MEMS) drug delivery device that is capable of releasing drugs in a controlled and programmable manner. This self-powered device does not require any external stimulation or control to achieve pulsatile release of drugs. The device consists of multiple reservoirs containing the drug embedded together with a water-swellable polymer. The swelling of the polymer u
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Maloney, John M. "An Implantable Microfabricated Drug Delivery System." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43186.

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We report on the development of a fully implantable drug delivery system capable of delivering hundreds of individual doses. This product is intended for the controlled release of potent therapeutic compounds that might otherwise require frequent injections. Our system has the following capabilities: • Stable, hermetic storage of therapeutic drugs in solid, liquid, or gel form; • Individual storage of discrete doses for multiple-drug regimens; • Wireless communication with an external controller for device monitoring and therapy modification; • Choice of preprogrammed release or release on com
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Benson, Michael, Daniel Chung, Gabriel Fuhrman, et al. "Three-Dimensional Concentration and Velocity Measurements of a Pulsatile Contaminant Release in a Model of Oklahoma City." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-23648.

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Abstract Motivated by the Joint Urban 2003 field project and subsequent studies, magnetic resonance imaging (MRI) techniques were used to collect full-field measurements of three-dimensional fluid velocity and concentration across a scaled model of 2003 Oklahoma City. The study was intended to develop, test, and demonstrate a repeatable puff release with MRI compatible equipment. In order to accomplish this, a contaminant was injected through the floor of a city model in discrete puffs using a solenoid valve. Sealed to fit inside a water channel, the 1:2,206 scale city model covered the centra
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O'Brien, C. C., C. H. Finch, P. Martens, T. J. Barber, and A. Simmons. "Development of an in vitro method for modeling drug release and subsequent tissue drug uptake and deposition in a pulsatile flow network." In 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2011. http://dx.doi.org/10.1109/iembs.2011.6090886.

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Petrykowski, John C. "Analysis of Fuel-Coolant Interaction Potential in Sodium Cooled Fast Reactor Safety Experiments." In 2012 20th International Conference on Nuclear Engineering and the ASME 2012 Power Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/icone20-power2012-54925.

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Improved utilization of nuclear fuels, burning of actinides and advancements in safety have brought about renewed interest in sodium cooled fast reactor technology. In regards to this and in light of recent events which have focused attention on new concerns involving safety, analyses have recently been performed addressing beyond design basis accident conditions for which the existence of large quantities of vaporized fuel and coolant have been postulated. Specifically, for very low probability, but highly energetic core disruptive accidents in sodium cooled fast reactors, molten and vaporize
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De Luca, Julio Cesar, and David Girard. "Correlation Between Clutch Hydraulic Release Pressure Pulsation and Pedal Vibration." In SAE 2002 World Congress & Exhibition. SAE International, 2002. http://dx.doi.org/10.4271/2002-01-1191.

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Yun, Sangsig, Joan Boulanger, and Leiyong Jiang. "Direct Numerical Simulation of Pulsating Jet Mixing." In ASME Turbo Expo 2007: Power for Land, Sea, and Air. ASMEDC, 2007. http://dx.doi.org/10.1115/gt2007-28062.

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In lean premixed combustors, the fuel/air ratio oscillation can cause a serious problem since it can produce pressure and heat release fluctuations, and further, combustion instability if it is well phased with them. In order to design a system where such air/fuel ratio fluctuation is well suppressed, it is important to understand the mixing process and its interaction with the flow structures inside a premixer. In this study, the flow-field of a pulsating jet and the mixing of the jet with the co-flow are examined using direct numerical simulation. The effects of the frequency and amplitude o
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Meier, U., L. Lange, J. Heinze, C. Hassa, S. Sadig, and D. Luff. "Optical Methods for Studies of Self-Excited Oscillations and the Effect of Dampers in a High Pressure Single Sector Combustor." In ASME Turbo Expo 2014: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/gt2014-25873.

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Self-excited periodic instabilities in a staged lean burn injector could be forced by operating the combustor at off-design conditions. These pressure oscillations were studied in a high pressure single sector combustor with optical access. Two damper configurations were installed and tested with respect to their damping efficiency in relation to the configuration without dampers. For a variety of test conditions, derived from a part load case, time traces of pressure in the combustor were measured, and amplitudes were derived from their Fourier transformation. These measurements were performe
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Giezendanner, R., P. Weigand, X. R. Duan, et al. "Laser Based Investigations of Periodic Combustion Instabilities in a Gas Turbine Model Combustor." In ASME Turbo Expo 2004: Power for Land, Sea, and Air. ASMEDC, 2004. http://dx.doi.org/10.1115/gt2004-53366.

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The driving mechanism of pulsations in gas turbine combustors depends on a complex interaction between flow field, chemistry, heat release, and acoustics. Experimental data on all these factors are therefore required to obtain insight into the coupling mechanisms during a pulsation period. In order to develop a comprehensive experimental data base to support a phenomenological understanding and to provide validation data for numerical simulation, a standard burner for optical investigations was established that exhibits strong self-excited oscillations. The burner was a swirl-stabilized non-pr
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Mondal, Sirshendu, Achintya Mukhopadhyay, and Swarnendu Sen. "Dynamic Characterization of a Laboratory-Scale Thermal Pulse Combustor." In ASME Turbo Expo 2012: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/gt2012-69273.

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Pulse combustors are widely applied for heating, drying and even propulsion applications because of their higher efficiency, higher heat transfer rates and lower emission than steady combustors. However, fundamentals of this pulse combustor remain till date largely unexplored. Experiments are conducted on a laboratory-scale thermal pulse combustor. The set-up consists of an upstream section, the combustor and the tailpipe. The optical signal from the flame is measured with a photomultiplier tube and pressure fluctuations are measured using a dynamic pressure transducer. The time series data re
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Reports on the topic "Pulsatile Release"

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Wolfenson, David, William W. Thatcher, and James E. Kinder. Regulation of LH Secretion in the Periovulatory Period as a Strategy to Enhance Ovarian Function and Fertility in Dairy and Beef Cows. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7586458.bard.

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The general research objective was to increase herd pregnancy rates by enhancing corpus luteum (CL) function and optimizing follicle development, in order to increase conception rate and embryo survival. The specific objectives were: to determine the effect of the duration of the preovulatory LH surge on CL function; to determine the function of LH during the postovulatory period on CL development; to optimize CL differentiation and follicle development by means of a biodegradable GnRH implant; to test whether optimization of CL development and follicle dynamics in timed- insemination protocol
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